CN116785334A - Traditional Chinese medicine composition for treating anorectal diseases and application thereof - Google Patents
Traditional Chinese medicine composition for treating anorectal diseases and application thereof Download PDFInfo
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Abstract
The application discloses a traditional Chinese medicine composition for treating anorectal diseases, which is prepared from the following raw materials in parts by weight: 40-45 parts of hydroxymethyl cellulose sodium, 40-45 parts of glucose powder, 5-10 parts of borneol and 5-10 parts of radix angelicae. Under the guidance of the theory of traditional Chinese medicine and clinical experience, the application creatively provides the traditional Chinese medicine composition and the proportion of each component thereof, so as to realize the effects of dehumidifying and relieving itching, detumescence and relieving pain, removing necrotic tissue and promoting granulation, and astringing dampness and healing sores aiming at anorectal diseases, and has good treatment effects on perianal eczema, skin itch, anus wetness, hemorrhoids, anal fissure, anal fistula, proctitis, perianal skin carbuncle furuncle and ulcer, various diseases, postoperative edema, pruritus, multiple secretion and other diseases of the postoperative stoma of the anorectal diseases, and is especially reflected in detumescence and pain relieving effects of the postoperative stoma of the anus. And has wide treatment range, convenient use and clinically satisfactory effect.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating anorectal diseases and application thereof.
Background
Anorectal diseases are typical common diseases and high incidence diseases of human beings, mainly comprise pruritus ani, perianal eczema, perianal inflammation, proctitis, hemorrhoids, multiple anal fissures and the like, can occur in any age group, can cause patients to have various uncomfortable symptoms such as intractable pruritus ani, anus pain, perianal abscess, perianal ulcer pain and the like, and bring serious influence to normal life of the patients.
For the anorectal diseases, the common method is to adopt the conservation treatment of operation treatment or non-operation, and for the anorectal diseases, the operation effect is often not exact enough, and the effective treatment of various anorectal diseases is difficult to realize. For the conservation treatment of diseases, the treatment is mainly realized by administration of medicines, and common medicine treatments comprise hemorrhoids ointment, hemorrhoid embolism into anus or traditional Chinese medicine hip bath and the like. Although the medicines including hemorrhoids ointment and hemorrhoids suppository can play a certain role in detumescence and analgesia, the medicines have certain limitations and have unsatisfactory effects. For example, the hemorrhoids ointment and the hemorrhoids suppository have certain detumescence and pain relieving effects, but have no antipruritic effect, and patients with anorectal diseases usually show various discomforts, such as anus wetness and anus itching of most patients with perianal diseases, and besides the hemorrhoids ointment and the hemorrhoids suppository, the more effective treatment effect can be achieved by being matched with other medicines for co-treatment. For example, the hip bath treatment of traditional Chinese medicine can achieve detumescence and analgesia, and part of traditional Chinese medicine also has the effect of relieving itching, but the final treatment effect is still poor. Moreover, the traditional Chinese medicine hip bath is extremely inconvenient, the hip bath time is long, the hip bath liquid is difficult to keep constant temperature, supercooling or overheating can influence the curative effect, and the local discomfort of a patient can be caused. Accordingly, there is a need in the art for an anorectal disorder drug that overcomes the shortcomings of the efficacy or mode of action of the drug in such conservative treatments.
Disclosure of Invention
The application aims to overcome at least one defect of the prior art, provides a traditional Chinese medicine composition for treating anorectal diseases and application thereof, can effectively treat the anorectal diseases, is suitable for various diseases, and is convenient to use.
The application adopts the technical scheme that the traditional Chinese medicine composition for treating anorectal diseases is prepared from the following raw materials in parts by weight: 40-45 parts of hydroxymethyl cellulose sodium, 40-45 parts of glucose powder, 5-10 parts of borneol and 5-10 parts of radix angelicae.
In one or more embodiments of the present application, the Chinese medicinal composition can effectively treat anorectal diseases, and can be applied to various symptoms to achieve corresponding therapeutic effects. Aiming at the defects of limited treatment means, non-ideal external medicine effect, short treatment maintenance time and the like in the prior art, the traditional Chinese medicine composition provided by the application can simultaneously achieve a plurality of curative effects of detumescence, analgesia, antipruritic, healing promotion and the like, and has obvious treatment effect and definite treatment effect; the traditional Chinese medicine composition provided by the application can stay on a focus for a long time, has long treatment maintenance time, and is a traditional Chinese medicine composition with strong pertinence, good curative effect, wide application range and convenient use. When the traditional Chinese medicine composition is used as powder, the traditional Chinese medicine composition can be applied to a treatment part, sprayed on the surface of a rectal mucosa and the like for administration, and the treatment mode is convenient and comfortable and is more acceptable by patients.
In one or more embodiments of the application, the sodium carboxymethyl cellulose: has good absorption capacity, can play a role in diminishing inflammation and astringing, and is suitable for redness, itching, pimple and the like of skin; glucose powder: the traditional Chinese medicine composition has strong hygroscopicity, has the effects of detumescence and pain relief, and can play a role in accelerating ulcer healing when being externally used for chronic ulcer wounds; borneol: has effects of inducing resuscitation, dispelling pathogenic fire, removing nebula, improving eyesight, relieving swelling and pain, and can be used for treating vomiting at middle-jiao, unconsciousness due to pyrexia, convulsion, phlegm, deafness due to qi obstruction, sore throat, otitis media, carbuncle, swelling, hemorrhoid, nebula, enterobiasis, etc.; radix angelicae: has effects of dispelling pathogenic wind and dampness, promoting blood circulation, expelling pus, promoting granulation, and relieving pain, and can be used for treating headache, toothache, nasosinusitis, intestinal wind, anal fistula, leucorrhea with red and white discharge, carbuncle, skin ulcer, and skin pruritus.
The traditional medicine considers that common diseases of anus and rectum such as hemorrhoids, anal fissure, perianal abscess, perianal eczema and the like, the main causes of pain, edema and pruritus are caused by improper diet of patients, damp-heat generation caused by damaging spleen and stomach and the like, and the damp and heat accumulation is caused by downward pouring into anus large intestine, so that qi and blood channels are blocked, blood stasis and heat are mutually combined, or the damp and heat accumulation and pathogenic factors are mutually combined, the pain of anus edema, the discomfort of anus weighing and swelling, difficult healing of ulcer seepage, perianal eczema and the like are caused, and the pathogenesis is damp-heat generation, qi stagnation and blood stasis, pain caused by obstruction and the damp-heat accumulation causes skin flush, itching and erosion exudation. The application creatively combines the characteristics of each component in the traditional Chinese medicine composition based on the etiology and characterization of the anorectal diseases so as to realize the treatment of the anorectal diseases.
In order to achieve corresponding curative effects in multiple aspects and be suitable for various anorectal diseases, the application achieves the aim at least from three aspects of detumescence and pain relief, slough removal and granulation promotion, dehumidification and itching relief through the cooperation of the components in the traditional Chinese medicine composition, wherein: (1) detumescence and pain relieving: the borneol has strong hygroscopicity, has the effects of detumescence and analgesia, promoting wound healing, expelling wind-damp, promoting blood circulation and pus discharge, promoting granulation and analgesia, and can reduce swelling and relieve pain when the three are matched; (2) removing necrotic tissue and promoting tissue regeneration: radix angelicae has effects of promoting blood circulation, expelling pus, promoting granulation and relieving pain; the glucose powder absorbs moisture, and can heal sore and promote tissue regeneration; the sodium hydroxymethyl cellulose has good absorption capacity and has the functions of diminishing inflammation and astringing. The three are matched to remove the necrotic tissue and promote tissue regeneration; (3) dehumidification and itching relief: the sodium hydroxymethyl cellulose has the effects of diminishing inflammation, astringing and relieving itching, can reduce skin problems, and has the effects of dispelling wind and dampness and simultaneously removing dampness and relieving itching. The traditional Chinese medicine composition disclosed by the application has multiple curative effects, is suitable for various anorectal diseases and is stable in curative effect and convenient to administer.
Based on the formula components provided by the application, the excellent detumescence and antipruritic effects can be realized by only matching borneol, angelica dahurica with sodium hydroxymethyl cellulose and glucose powder, the treatment of perianal eczema, pruritus ani, edema of operation mouth and other diseases is realized, and the detumescence and antipruritic effects are obvious. Meanwhile, the application mainly utilizes the water absorption of the glucose powder to apply the glucose powder to the edema of the anus Zhou Zhichang disease for detumescence, has obvious detumescence effect and has remarkable effect on the treatment of the perianal operation mouth edema.
Further, the material is prepared from the following raw materials in parts by weight: 43 parts of sodium hydroxymethyl cellulose, 43 parts of glucose powder, 7 parts of borneol and 7 parts of radix angelicae. In more than one embodiment of the application, the traditional Chinese medicine composition prepared by adopting the weight parts has excellent effect.
The application also aims to provide a preparation method of the traditional Chinese medicine composition, which comprises the steps of weighing sodium hydroxymethyl cellulose, glucose powder, borneol and radix angelicae according to the selected weight portions, physically crushing and sieving the components, and then mixing the components. The preparation method provided by the application is simple, easy to operate and prepare and beneficial to mass production and utilization.
Still another object of the present application is to provide the use of the above-mentioned Chinese medicinal composition in preparing a medicament for preventing or treating anorectal diseases.
Further, the method comprises the steps of, the anorectal diseases comprise perianal eczema, perianal skin itch, anal wetness, hemorrhoids, anal fissure, anal fistula, proctitis, postoperative port edema of perianal diseases postoperative pruritus and postoperative secretion of perianal diseases are more, postoperative pain and furuncle and ulcer of perianal skin are not healed after operation of anus.
In one or more embodiments of the present application, the Chinese medicinal composition can be applied to various symptoms caused by perianal common diseases for treatment, and the treatment of diseases or symptoms mainly comprises: perianal eczema, skin itch, anal wetness, hemorrhoids, anal fissure, anal fistula, proctitis, postoperative edema of various perianal diseases, pruritus, more secretion, disunion after perianal skin carbuncles and furuncles, and the like. The traditional Chinese medicine composition and the traditional Chinese medicine preparation provided by the application have good effects of detumescence and pain relief and itching relief for the operation mouth of the anus.
Further, the anorectal diseases include edema after mixed hemorrhoid operation, anal fissure, swelling and pain after perianal abscess operation, perianal eczema and proctitis.
It is a further object of the present application to provide the use of sodium hydroxymethylcellulose in the preparation of a medicament for the prevention or treatment of anorectal diseases.
Still another object of the present application is to provide a Chinese medicinal preparation for treating anorectal diseases, comprising the aforementioned Chinese medicinal composition and a pharmaceutically acceptable carrier. In particular to a traditional Chinese medicine preparation which takes plant minerals as raw materials to treat common diseases of anus and rectum (such as pruritus ani, perianal eczema, mixed hemorrhoids, anal fissure, proctitis, anal operation stomatitis and edema, etc.).
Further, the dosage forms of the traditional Chinese medicine preparation comprise gel, cream, tablet, capsule, powder, mixture, pill, granule, solution, syrup, decoction, suppository, aerosol, emplastrum, ointment, injection, spray, liniment, tincture, wet compress, paste or lotion.
Further, the traditional Chinese medicine preparation is in the form of powder, suppository, spray, agent, ointment or lotion. Aiming at anorectal diseases, the powder, the suppository, the spray, the agent, the ointment or the lotion can play a corresponding role in administration, and the administration is convenient and is easy to be accepted by patients.
In more than one embodiment of the application, the traditional Chinese medicine composition is prepared and packaged into powder for external use, the powder is externally used for 2 times a day in the morning and evening, each time is 2-5 g,7 days is a treatment course, and after 2-3 treatment courses, patients suffering from the anus Zhou Zhichang disease are effectively treated, and the symptoms are relieved or healed.
Further, the pharmaceutically acceptable carrier is at least one selected from pharmaceutically acceptable solvents, solubilizers, cosolvents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adherents, integrating agents, permeation enhancers, pH regulators, buffers, plasticizers, surfactants, thickeners, coating agents, humectants, absorbents, diluents, flocculant and deflocculant, filter aids, release retarders, polymeric matrix materials, and film forming materials.
Further, at least one of a pharmaceutically acceptable solvent, a preservative, a polymeric matrix material and a film-forming material.
Still another object of the present application is to provide an anorectal disease treatment system, comprising a drug application module for applying the above-mentioned traditional Chinese medicine composition or the above-mentioned traditional Chinese medicine preparation, wherein the amount of the traditional Chinese medicine composition in the single drug application amount of the drug application module is 2g-5 g.
Further, a timed reminder device is included for reminding the application of the medicament.
Compared with the prior art, the application has the beneficial effects that: under the guidance of the theory of traditional Chinese medicine and clinical experience, the application creatively provides the traditional Chinese medicine composition and the proportion of each component thereof, so as to realize the effects of dehumidifying and relieving itching, detumescence and relieving pain, removing necrotic tissue and promoting granulation, and astringing dampness and healing sores aiming at anorectal diseases, and has good treatment effects on perianal eczema, skin itch, anus wetness, hemorrhoids, anal fissure, anal fistula, proctitis, perianal skin carbuncle furuncle and ulcer, various diseases, postoperative edema, pruritus, multiple secretion and other diseases of the postoperative stoma of the anorectal diseases, and is especially reflected in detumescence and pain relieving effects of the postoperative stoma of the anus. The traditional Chinese medicine composition and the traditional Chinese medicine preparation provided by the application are mainly used for treating common diseases of anus and rectum, and are directly used for treating focus of infection, local application and disease differentiation. And has wide treatment range, convenient use, easy acceptance by patients and clinical satisfaction.
Detailed Description
It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.
The application will now be further illustrated with reference to specific examples, which are given solely for the purpose of illustration and are not to be construed as limiting the application. The test specimens and test procedures used in the following examples include those (if the specific conditions of the experiment are not specified in the examples, generally according to conventional conditions or according to the recommended conditions of the reagent company; the reagents, consumables, etc. used in the examples described below are commercially available unless otherwise specified).
Example 1
A Chinese medicinal powder for treating anorectal common diseases is provided: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
40 parts of sodium hydroxymethyl cellulose, 40 parts of glucose powder, 5 parts of borneol and 5 parts of radix angelicae.
The preparation process is as follows: preparing the medicines in parts by weight, physically crushing, sieving, mixing, dividing into doses, and finally packaging into powder.
Example 2
A Chinese medicinal powder for treating anorectal common diseases is provided: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
43 parts of sodium hydroxymethyl cellulose, 43 parts of glucose powder, 7 parts of borneol and 7 parts of radix angelicae.
The preparation process is as follows: preparing the medicines in parts by weight, physically crushing, sieving, mixing, dividing into doses, and finally packaging into powder.
Example 3
A Chinese medicinal powder for treating anorectal common diseases is provided: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
45 parts of sodium hydroxymethyl cellulose, 45 parts of glucose powder, 10 parts of borneol and 10 parts of radix angelicae.
The preparation process is as follows: preparing the medicines in parts by weight, physically crushing, sieving, mixing, dividing into doses, and finally packaging into powder.
Example 4
A Chinese medicinal ointment for treating anorectal diseases is provided: weighing the following raw materials in parts by weight: 43 parts of sodium hydroxymethyl cellulose, 43 parts of glucose powder, 7 parts of borneol and 7 parts of radix angelicae; pulverizing, sieving, mixing, adding conventional adjuvants, mixing, and making into ointment.
Example 5
A Chinese medicinal suppository for treating anorectal common diseases is provided: weighing the following raw materials in parts by weight: 43 parts of sodium hydroxymethyl cellulose, 43 parts of glucose powder, 7 parts of borneol and 7 parts of radix angelicae; pulverizing, sieving, mixing, adding conventional adjuvants, mixing, and making into suppository.
Test example 1
(1) Clinical data: the application treats 100 cases of common anorectal diseases, and 100 cases of patients are accompanied with uncomfortable symptoms such as anus pain, edema, swelling discomfort, skin swelling furuncle, difficult healing of wound after ulcer, moist anus, pruritus ani and the like to different degrees.
30 cases of mixed hemorrhoids postoperative oedema, 15 cases of men and 15 cases of women, and the ages of the men and the women are 25-50 years; anal fissure 20 cases, male 8 cases and female 12 cases, with ages of 27-55 years old; 15 cases of perianal abscess postoperative swelling and pain, 12 cases of men and 3 cases of women; the age is 22 to 50 years old; 20 cases of perianal eczema, 13 men and 7 women, and the ages of 20-60 years old; proctitis 15 cases, 8 men and 7 women, ages 20-47 years old.
(2) The treatment method comprises the following steps: the traditional Chinese medicine composition is prepared into powder for external use, and the following raw material medicines in parts by weight are used: 45 parts of sodium hydroxymethyl cellulose, 45 parts of glucose powder, 10 parts of borneol, 10 parts of angelica dahurica and 2 times of external application in the morning and evening each time, wherein 2g-5g of the plaster is applied to a focus according to the illness state of a patient each time, and 7 days are a course of treatment, and generally 2-3 courses of treatment are taken.
(3) Efficacy evaluation criteria: the therapeutic effect is shown in table 1:
table 1 comparison of efficacy of improvement of symptoms of common anorectal diseases:
note that: * Total effective rate = [ (clinical cure + onset + effectiveness)/observed case number ] ×100%.
Conclusion: from Table 1, it can be seen that the medicine has remarkable curative effects on patients with common anorectal diseases, and the return visit after the treatment by adopting the traditional Chinese medicine composition shows that other uncomfortable symptoms appear after the patients are not found to use the powder at present, and a satisfactory treatment effect is achieved.
Test example 2
Medical records one: postoperative edema of annular mixed hemorrhoids
Cai Mou after 3 days of mixed hemorrhoid surgery, edema appears in men, 69 years old.
The patients have obvious edema and pain after defecation due to PPH operation and external peeling and internal bundling operation of the annular mixed hemorrhoids before 3 days, and the patients have difficult defecation due to anus distension and anus distension, and the patients are not relieved after external use of the Mafenglong musk hemorrhoids ointment and the traditional Chinese medicine hip bath.
Special examination: the examination of the anal lithotomy site can show that 3, 9 and 11 mixed hemorrhoids have obvious edema, more secretion and obvious tenderness.
Treatment: the traditional Chinese medicine powder for treating common diseases of the anorectum and the rectum of the embodiment 1 is applied to the anus and the anal canal by using cotton balls, is clinically cured in 2 treatment courses, is followed up after 1 month, and does not relapse.
And a second medical record: postoperative perianal abscess
Somebody's, 30 years old, post perianal abscess operation.
The patient is diagnosed with perianal abscess and treated by surgery for 6 days with swelling and pain around the anus, and the postoperative has more secretion.
Special examination: the anus has a length of about 4CM, more secretions are seen, and the skin of the anus is slightly red.
Treatment: the external traditional Chinese medicine powder for treating common diseases of the anorectum has obvious effect after 1 treatment course, the operation mouth is dry and clean, secretion is avoided, the operation mouth is basically healed after 2 treatment courses, the operation mouth is completely healed after 3 treatment courses, and no recurrence is caused after follow-up after 3 months.
And a third medical record: perianal eczema
Li Mou, men, 42 years old, recurrent perianal itching for half a year.
The patients have no obvious cause of perianal itching before half a year, and can self-apply antipruritic ointment, so that the symptoms are improved, but the symptoms are repeated, the itching is obviously aggravated recently, the antipruritic ointment is ineffective, and the stool is flat and rotten for 3-4 times per day.
Special examination: visual inspection: the perianal skin is thickened, white in color, rough, chapped and damaged, and punctiform ulcers are seen in part. Finger diagnosis: the skin can be obviously thickened, roughened and pressed.
Treatment: the external traditional Chinese medicine powder for treating common diseases of the anorectum has obvious effect after 1 treatment course, the perianal skin is clean, secretion is avoided, the pruritus is obviously relieved, the pruritus disappears after 2 treatment courses, the perianal skin basically recovers the normal color after 3 treatment courses, and the skin does not relapse after follow-up after 1 month.
It should be understood that the foregoing examples of the present application are merely illustrative of the present application and are not intended to limit the present application to the specific embodiments thereof. Any modification, equivalent replacement, improvement, etc. that comes within the spirit and principle of the claims of the present application should be included in the protection scope of the claims of the present application.
Claims (10)
1. The traditional Chinese medicine composition for treating anorectal diseases is characterized by being prepared from the following raw materials in parts by weight: 40-45 parts of hydroxymethyl cellulose sodium, 40-45 parts of glucose powder, 5-10 parts of borneol and 5-10 parts of radix angelicae.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 43 parts of sodium hydroxymethyl cellulose, 43 parts of glucose powder, 7 parts of borneol and 7 parts of radix angelicae.
3. The preparation method of the traditional Chinese medicine composition according to any one of claims 1-2, which is characterized in that the preparation method comprises the steps of weighing sodium hydroxymethyl cellulose, glucose powder, borneol and radix angelicae according to the selected weight portions, physically crushing and sieving the components, and then mixing the components.
4. Use of a traditional Chinese medicine composition according to any one of claims 1-2 for the preparation of a medicament for the prevention or treatment of anorectal diseases.
5. The use according to claim 4, wherein said anorectal diseases comprise perianal eczema, perianal skin itch, anal wetness, hemorrhoids, anal fissure, anal fistula, proctitis, perianal postoperative stoma edema, perianal postoperative stoma itch, perianal postoperative stoma secretion is high, postoperative anal pain, perianal skin carbuncles and furuncles are not healed after a burst.
6. The use according to claim 5, wherein said anorectal diseases comprise edema following mixed hemorrhoids, anal fissure, perianal abscess, perianal eczema, proctitis.
7. A Chinese medicinal preparation for treating anorectal diseases, which comprises the Chinese medicinal composition according to any one of claims 1-2 and a pharmaceutically acceptable carrier.
8. The traditional Chinese medicine preparation according to claim 7, wherein the dosage form of the traditional Chinese medicine preparation comprises gel, cream, tablet, capsule, powder, mixture, pill, granule, solution, syrup, decoction, suppository, aerosol, emplastrum, ointment, injection, spray, liniment, tincture, wet compress, paste or lotion.
9. The traditional Chinese medicine preparation according to claim 7, wherein the pharmaceutically acceptable carrier is at least one selected from pharmaceutically acceptable solvents, solubilizers, cosolvents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adhesive agents, integrating agents, permeation promoters, pH regulators, buffers, plasticizers, surfactants, thickeners, coating agents, humectants, absorbents, diluents, flocculant and deflocculant, filter aids, release retarders, polymeric matrix materials and film forming materials.
10. An anorectal disease treatment system comprising a drug administration module for administering the traditional Chinese medicine composition of any one of claims 1 to 2 or the traditional Chinese medicine preparation of any one of claims 7 to 9, wherein the amount of the traditional Chinese medicine composition is 2g to 5g when the drug administration module is administered with a single drug.
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| CN202210253845.6A CN116785334A (en) | 2022-03-15 | 2022-03-15 | Traditional Chinese medicine composition for treating anorectal diseases and application thereof |
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| CN202210253845.6A CN116785334A (en) | 2022-03-15 | 2022-03-15 | Traditional Chinese medicine composition for treating anorectal diseases and application thereof |
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