CN116761587A - 用于护理和/或化妆角蛋白材料的组合物 - Google Patents
用于护理和/或化妆角蛋白材料的组合物 Download PDFInfo
- Publication number
- CN116761587A CN116761587A CN202080108305.8A CN202080108305A CN116761587A CN 116761587 A CN116761587 A CN 116761587A CN 202080108305 A CN202080108305 A CN 202080108305A CN 116761587 A CN116761587 A CN 116761587A
- Authority
- CN
- China
- Prior art keywords
- composition
- sorbitan
- alcohol
- glycerol
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 121
- 239000000463 material Substances 0.000 title claims abstract description 22
- 102000011782 Keratins Human genes 0.000 title claims abstract description 20
- 108010076876 Keratins Proteins 0.000 title claims abstract description 20
- -1 fatty acid esters Chemical class 0.000 claims abstract description 51
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 49
- 239000000049 pigment Substances 0.000 claims abstract description 46
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 45
- 239000000194 fatty acid Substances 0.000 claims abstract description 45
- 229930195729 fatty acid Natural products 0.000 claims abstract description 45
- 239000004094 surface-active agent Substances 0.000 claims abstract description 28
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 16
- 239000003974 emollient agent Substances 0.000 claims abstract description 14
- 239000007764 o/w emulsion Substances 0.000 claims abstract description 7
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 5
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 27
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 27
- 229920000223 polyglycerol Polymers 0.000 claims description 22
- 229960000541 cetyl alcohol Drugs 0.000 claims description 14
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 13
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 12
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 10
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 10
- 229940012831 stearyl alcohol Drugs 0.000 claims description 10
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 7
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 7
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 claims description 6
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 6
- 229940057429 sorbitan isostearate Drugs 0.000 claims description 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 5
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 5
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 5
- 229910044991 metal oxide Inorganic materials 0.000 claims description 5
- 150000004706 metal oxides Chemical class 0.000 claims description 5
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 5
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 5
- 229940113124 polysorbate 60 Drugs 0.000 claims description 5
- QHZLMUACJMDIAE-SFHVURJKSA-N 1-hexadecanoyl-sn-glycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)CO QHZLMUACJMDIAE-SFHVURJKSA-N 0.000 claims description 4
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 4
- AZLWQVJVINEILY-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCOCCOCCO AZLWQVJVINEILY-UHFFFAOYSA-N 0.000 claims description 4
- QHZLMUACJMDIAE-UHFFFAOYSA-N Palmitic acid monoglyceride Natural products CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 claims description 4
- 229920002642 Polysorbate 65 Polymers 0.000 claims description 4
- 229920002651 Polysorbate 85 Polymers 0.000 claims description 4
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 4
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 4
- 229940100491 laureth-2 Drugs 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 229940102545 peg-20 sorbitan isostearate Drugs 0.000 claims description 4
- REIUXOLGHVXAEO-UHFFFAOYSA-N pentadecan-1-ol Chemical compound CCCCCCCCCCCCCCCO REIUXOLGHVXAEO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 claims description 4
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 claims description 4
- 229940099511 polysorbate 65 Drugs 0.000 claims description 4
- 229940068968 polysorbate 80 Drugs 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
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- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 4
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 4
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 4
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 3
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 3
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 3
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- 235000011076 sorbitan monostearate Nutrition 0.000 claims description 3
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- 229960005078 sorbitan sesquioleate Drugs 0.000 claims description 3
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- 239000005720 sucrose Substances 0.000 claims description 3
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 claims description 2
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- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
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- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
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Abstract
本发明涉及呈水包油乳液形式的用于护理和/或化妆角蛋白材料的组合物,其包含:(i)至少一种第一表面活性剂,其选自具有衍生自2‑10个甘油单元的聚甘油部分的聚甘油脂肪酸酯;(ii)至少一种第二表面活性剂,其与如上所定义的聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<15;(iii)至少一种饱和C12‑C24脂肪醇;(iv)至少一种润肤剂;和(v)相对于组合物的总重量计,至少1.5wt.%的有色颜料。本发明还涉及用于护理和/或化妆角蛋白材料的非治疗性方法,其包括将所述组合物施用于皮肤。
Description
技术领域
本发明涉及化妆品组合物。尤其,本发明涉及用于护理和/或化妆角蛋白材料的组合物。本发明还涉及用于护理和/或化妆角蛋白材料的非治疗性方法。
背景技术
致力于护理和/或化妆皮肤和/或嘴唇的配制品的开发是永久的。
作为对环境的保护和交换屏障的皮肤既强壮又脆弱,它可能失去其柔性并且其保水能力降低,从而导致皮肤干燥。
已知作为表皮最外侧区域的角质层或角膜层最尤其牵涉保湿皮肤。
位于与外部环境的界面处,其功能特别是延迟产生自表皮的较深层的过度水分流失。角质层还抵御机械攻击。其还构成对抗UV辐射的第一道防线。
已知,随着年龄的增长,经常观察到皮肤干燥的增加;然而,此类皮肤干燥状态也可能出现在年轻对象中。这是因为皮肤干燥状态是在没有任何病理原因,至少没有明显病理原因的情况下,可能存在于年轻对象中的生理状态。许多外部因素可以导致皮肤的干燥或者可以使已经干燥的皮肤状态恶化。在这些因素之中,可提及恶劣的气候条件、太阳辐射或暴露于某些化学试剂或治疗剂下。因此,生产一些用于水合皮肤的产品是合意的。
另外,为了获得合意的化妆效果,有时候将较大量的颜料并入用于护理和/或化妆皮肤的组合物中。然而,难以获得含有较大量的颜料的稳定的化妆品组合物。
因此,仍然需要配制用于护理和/或化妆皮肤的组合物,其可提供合意的化妆效果和水合效果,同时其是稳定的。
发明概述
发明人现已发现,有可能配制具有如上文所描述的所需性质的此类组合物。
具体地,发明人已发现,有可能配制用于护理和/或化妆皮肤的稳定组合物,其可提供合意的化妆效果和水合。
因此,在第一方面,本发明提供呈水包油乳液形式的用于护理和/或化妆角蛋白材料的组合物,其包含:
(i)至少一种第一表面活性剂,其选自具有衍生自2-10个甘油单元的聚甘油部分的聚甘油脂肪酸酯;
(ii)至少一种第二表面活性剂,其与如上所定义的聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<15;
(iii)至少一种饱和C12-C24脂肪醇;
(iv)至少一种润肤剂;和
(v)相对于组合物的总重量计,至少1.5wt.%的有色颜料。
本发明组合物呈水包油乳液的形式。因此,所述组合物包含连续水相和分散脂肪相。
在本申请的上下文中,“稳定的组合物”意味着所含的颜料均匀地分散在组合物中。
发明人发现,本发明组合物具有层状结构或层状结构化相,以致所含的颜料均匀地分散于该组合物中。
发明人进一步发现,层状结构或层状结构化相由以下物质的组合形成:(i)至少一种第一表面活性剂,其选自具有衍生自2-10个甘油单元的聚甘油部分的聚甘油脂肪酸酯;(ii)至少一种第二表面活性剂,其与如上所定义的聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<15;和(iii)至少一种饱和C12-C24脂肪醇。
本发明组合物可提供良好的化妆效果(即,覆盖率)和水合效果。
在第二方面,本发明提供用于护理和/或化妆角蛋白材料的非治疗性方法,其包括将根据本发明的第一方面的组合物施用于角蛋白材料。
本发明的其它优点将在阅读以下说明书和实施例时更清楚地显现。
附图简述
仅通过举例方式,现将参考附图来描述本发明的实施,其中:
图1显示了利用偏振光显微镜拍摄的发明例1(I E.1)的组合物的照片。
发明详述
除非另外定义,否则本文中使用的所有技术和科学术语都具有与本发明所属领域的技术人员所通常理解的相同的含义。当术语在本说明书中的定义与本发明所属领域的技术人员所通常理解的含义冲突时,本文所描述的定义应当适用。
在以下内容中,且除非另外指明,否则数值范围的上下限包括在该范围内,在表述“介于……和……之间”和“范围为……至……”中尤其如此。
此外,本说明书中使用的表述“至少一个/种”等同于表述“一个/种或更多个/种”。
贯穿本申请,术语“包含/括”应解释为涵盖所有具体提及的特征以及任选的、另外的、未指明的特征。如本文中所用的,术语“包含/括”的使用还公开了其中不存在除具体提及的特征之外的特征(即,“由具体提及的特征组成”)的实施方案。
除非另外指明,否则说明书和权利要求书中使用的表示成分的量等等的所有数值都应理解为被术语“约”修饰。因此,除非相反指明,否则本文中描述的数值和参数是能够根据所需目的而视需要变化的近似值。
用于本发明的目的,术语“角蛋白材料”意欲涵盖人的皮肤、粘膜,例如嘴唇。根据本发明最特别考虑的是面部皮肤。
除非另外指明,否则本发明中的所有百分比指重量百分比。
根据第一方面,本发明提供呈水包油乳液形式的用于护理和/或化妆角蛋白材料的组合物,其包含:
(i)至少一种第一表面活性剂,其选自具有衍生自2-10个甘油单元的聚甘油部分的聚甘油脂肪酸酯;
(ii)至少一种第二表面活性剂,其与如上所定义的聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<15;
(iii)至少一种饱和C12-C24脂肪醇;
(iv)至少一种润肤剂;和
(v)相对于组合物的总重量计,至少1.5wt.%的有色颜料。
聚甘油脂肪酸酯
根据第一方面,本发明组合物包含至少一种第一表面活性剂,其选自具有衍生自2-10个甘油单元的聚甘油部分的聚甘油脂肪酸酯。
聚甘油脂肪酸酯可选自包括10-22个碳原子的饱和或不饱和脂肪酸的单酯、二酯和三酯,所述脂肪酸例如为月桂酸、油酸、硬脂酸、异硬脂酸、癸酸、辛酸和肉豆蔻酸。
聚甘油脂肪酸酯可选自PG2癸酸酯、PG2二癸酸酯、PG2三癸酸酯、PG2辛酸酯、PG2二辛酸酯、PG2三辛酸酯、PG2月桂酸酯、PG2二月桂酸酯、PG2三月桂酸酯、PG2肉豆蔻酸酯、PG2二肉豆蔻酸酯、PG2三肉豆蔻酸酯、PG2硬脂酸酯、PG2二硬脂酸酯、PG2三硬脂酸酯、PG2异硬脂酸酯、PG2二异硬脂酸酯、PG2三异硬脂酸酯、PG2油酸酯、PG2二油酸酯、PG2三油酸酯、PG3癸酸酯、PG3二癸酸酯、PG3三癸酸酯、PG3辛酸酯、PG3二辛酸酯、PG3三辛酸酯、PG3月桂酸酯、PG3二月桂酸酯、PG3三月桂酸酯、PG3肉豆蔻酸酯、PG3二肉豆蔻酸酯、PG3三肉豆蔻酸酯、PG3硬脂酸酯、PG3二硬脂酸酯、PG3三硬脂酸酯、PG3异硬脂酸酯、PG3二异硬脂酸酯、PG3三异硬脂酸酯、PG3油酸酯、PG3二油酸酯、PG3三油酸酯、PG4癸酸酯、PG4二癸酸酯、PG4三癸酸酯、PG4辛酸酯、PG4二辛酸酯、PG4三辛酸酯、PG4月桂酸酯、PG4二月桂酸酯、PG4三月桂酸酯、PG4肉豆蔻酸酯、PG4二肉豆蔻酸酯、PG4三肉豆蔻酸酯、PG4硬脂酸酯、PG4二硬脂酸酯、PG4三硬脂酸酯、PG4异硬脂酸酯、PG4二异硬脂酸酯、PG4三异硬脂酸酯、PG4油酸酯、PG4二油酸酯、PG4三油酸酯、PG5癸酸酯、PG5二癸酸酯、PG5三癸酸酯、PG5辛酸酯、PG5二辛酸酯、PG5三辛酸酯、PG5月桂酸酯、PG5二月桂酸酯、PG5三月桂酸酯、PG5肉豆蔻酸酯、PG5二肉豆蔻酸酯、PG5三肉豆蔻酸酯、PG5硬脂酸酯、PG5二硬脂酸酯、PG5三硬脂酸酯、PG5异硬脂酸酯、PG5二异硬脂酸酯、PG5三异硬脂酸酯、PG5油酸酯、PG5二油酸酯、PG5三油酸酯、PG6癸酸酯、PG6二癸酸酯、PG6三癸酸酯、PG6辛酸酯、PG6二辛酸酯、PG6三辛酸酯、PG6月桂酸酯、PG6二月桂酸酯、PG6三月桂酸酯、PG6肉豆蔻酸酯、PG6二肉豆蔻酸酯、PG6三肉豆蔻酸酯、PG6硬脂酸酯、PG6二硬脂酸酯、PG6三硬脂酸酯、PG6异硬脂酸酯、PG6二异硬脂酸酯、PG6三异硬脂酸酯、PG6油酸酯、PG6二油酸酯、PG6三油酸酯、PG10癸酸酯、PG10二癸酸酯、PG10三癸酸酯、PG10辛酸酯、PG10二辛酸酯、PG10三辛酸酯、PG10月桂酸酯、PG10二月桂酸酯、PG10三月桂酸酯、PG10肉豆蔻酸酯、PG10二肉豆蔻酸酯、PG10三肉豆蔻酸酯、PG10硬脂酸酯、PG10二硬脂酸酯、PG10三硬脂酸酯、PG10异硬脂酸酯、PG10二异硬脂酸酯、PG10三异硬脂酸酯、PG10油酸酯、PG10二油酸酯和PG10三油酸酯。
更优选的是,聚甘油脂肪酸酯选自具有衍生自2-10个甘油单元的聚甘油部分、具有或没有糖部分的聚甘油C10-C22脂肪酸酯,例如:
-包含2-10个甘油单元的聚甘油单月桂酸酯,
-包含2-10个甘油单元的聚甘油单(异)硬脂酸酯,-包含2-10个甘油单元的聚甘油二硬脂酸酯,
-包含2-10个甘油单元的聚甘油单油酸酯,
-包含2-10个甘油单元的聚甘油二油酸酯,和
-包含2-10个甘油单元的聚甘油单癸酸酯。
甚至更优选的是,聚甘油脂肪酸酯选自具有衍生自2-10个甘油单元的聚甘油部分、具有或没有糖部分的聚甘油二硬脂酸酯。
作为具有衍生自2-10个甘油单元的聚甘油部分的聚甘油二硬脂酸酯的实例,可提及聚甘油-3二硬脂酸酯,例如由BASF公司以名称TGI销售的产品。
优选地,如果存在,则糖部分衍生自例如蔗糖、麦芽糖、葡萄糖、果糖或甲基葡萄糖。
作为具有衍生自2-10个甘油单元的聚甘油部分和糖部分的聚甘油二硬脂酸酯的实例,可提及甲基葡萄糖-聚甘油-3二硬脂酸酯,例如由Evonik Goldschmidt公司以名称Tego-Care 450销售的产品。
更优选地,聚甘油脂肪酸酯选自聚甘油-3二硬脂酸酯和甲基葡萄糖-聚甘油-3二硬脂酸酯。
在优选实施方案中,所使用的聚甘油脂肪酸酯是甲基葡萄糖-聚甘油-3二硬脂酸酯,其具有以下示意式:
有利地,相对于组合物的总重量计,聚甘油脂肪酸酯的存在量范围为0.1wt.%-15wt.%,优选0.5wt.%-8wt.%,且更优选1wt.%-5wt.%。
与如上所定义的聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<15的表面活 性剂根据第一方面,本发明组合物包含至少一种第二表面活性剂,其与如上所定义的聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<15。
根据J.Ploughshare.Cosm.Chem.1954(第5卷),第249-256页中Griffin的方法定义HLB(亲水-亲脂平衡)值。尤其,“HLB”值是指分散剂中亲水基团与亲脂基团的比率,并且还涉及分散剂的溶解性。较低HLB的分散剂在油(亲脂材料)中溶解性更大,并且更适合在油包水(W/O)乳液中使用。
优选地,第二表面活性剂选自非离子表面活性剂。
更优选地,第二表面活性剂选自甘油的C12-C24脂肪酸酯、失水山梨糖醇的脂肪酸酯、以及包含少于10个氧乙烯(OE)单元的氧乙烯化(OE)脂肪醇。
甘油的C12-C24脂肪酸酯
用于甘油的脂肪酸酯的C12-C24脂肪酸可以是不饱和酸或饱和酸,例如硬脂酸、油酸、棕榈酸。
作为甘油的C12-C24脂肪酸酯的实例,可提及甘油月桂酸酯、甘油油酸酯、甘油硬脂酸酯、甘油棕榈酸酯、甘油肉豆蔻酸酯、甘油花生酸酯、甘油山萮酸酯、及其混合物。
作为商业化产品,可提及甘油硬脂酸酯,例如由Evonik Goldschmidt公司以名称Tegin M销售的产品;甘油月桂酸酯,例如由Hiils公司以名称Imwitor 312销售的产品。
优选地,所使用的甘油的C12-C24脂肪酸酯选自甘油的C16-C22脂肪酸酯。更优选地,所使用的甘油的C12-C24脂肪酸酯是甘油硬脂酸酯。
失水山梨糖醇的脂肪酸酯
任选地,失水山梨糖醇的脂肪酸酯是氧化烯化的,优选氧乙烯化的。
可更特别提及的这种类型的表面活性剂包括失水山梨糖醇的C12-C22脂肪酸酯,例如(INCI名称)失水山梨糖醇异硬脂酸酯、失水山梨糖醇月桂酸酯、失水山梨糖醇单硬脂酸酯、失水山梨糖醇硬脂酸酯、失水山梨糖醇倍半油酸酯、失水山梨糖醇三油酸酯;氧乙烯化的失水山梨糖醇C12-C22脂肪酸酯,例如(INCI名称)聚山梨酯60、聚山梨酯65、聚山梨酯80、聚山梨酯85、PEG-20失水山梨糖醇异硬脂酸酯、PEG-40失水山梨糖醇全油酸酯、及其混合物。
作为氧化烯化的失水山梨糖醇脂肪酸酯的商品,可提及聚山梨酯60,例如由Croda公司以商品名TWEENTM 60-LQ-(MV)销售的产品。
包含少于10个OE单元的氧乙烯化脂肪醇
包含少于10个OE单元的氧乙烯化脂肪醇可包含1-9个OE单元,且优选选自饱和或不饱和的、直链或支链(优选直链)C8-C30(且优选C12-C22)脂肪醇的氧乙烯化衍生物,该脂肪醇例如鲸蜡醇、油醇、油鲸蜡醇、月桂醇、山萮醇、鲸蜡硬脂醇、硬脂醇和异硬脂醇、及其混合物。
作为包含少于10个OE单元的氧乙烯化脂肪醇,优选提及包含2-8个且优选2-6个OE单元的氧乙烯化脂肪醇,例如氧化乙烯与月桂醇的加成产物,例如月桂醇2OE(CTFA名称:月桂醇聚醚-2);氧化乙烯与硬脂醇的加成产物,例如硬脂醇2OE(CTFA名称:硬脂醇聚醚-2);氧化乙烯与癸醇的加成产物,例如癸醇3OE(CTFA名称:癸醇聚醚-3)、癸醇5OE(CTFA名称:癸醇聚醚-5);氧化乙烯与油鲸蜡醇的加成产物,例如油鲸蜡醇5OE(CTFA名称:油鲸蜡醇聚醚-5);及其混合物。
甚至更优选地,将使用的氧乙烯化脂肪醇是包含2-4个OE单元的氧乙烯化C12-C22脂肪醇,且仍更佳是包含2个OE单元的那些。
优选地,第二表面活性剂选自甘油的C16-C22脂肪酸酯、氧乙烯化的失水山梨糖醇C12-C22脂肪酸酯、以及包含2-4个OE单元的氧乙烯化C12-C22脂肪醇。
有利地,相对于组合物的总重量计,与如上所定义的聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<i5的第二表面活性剂的存在量范围为0.1wt.%-20wt.%,优选0.5wt.%-15wt.%,更优选0.5wt.%-10wt.%。
饱和C12-C24脂肪醇
根据第一方面,根据本发明的组合物包含至少一种饱和C12-C24脂肪醇。
用于本发明的目的,饱和C12-C24脂肪醇是直链的。优选地,该脂肪醇包含14-22个碳原子。
适合在本发明中使用的脂肪醇优选选自鲸蜡醇、硬脂醇、鲸蜡硬脂醇、肉豆蔻醇、月桂醇、十三烷醇、十五烷醇、十六烷醇、花生醇、山萮醇、其混合物;它们优选选自鲸蜡醇、硬脂醇和鲸蜡硬脂醇。
作为可最特别适合在本发明中使用的鲸蜡醇,可使用例如以下列名称销售的产品:16/98F和/>16/98P,由Ecogreen Oleochemicals公司销售;/>16,由Evonik Goldschmidt公司销售;/>16,由Cognis公司销售;/>1698,由VVF公司销售;/>1698P,由Oxiteno公司销售;Cetyl Alcohol 98%Min,由EmeryOleochemicals公司销售;/>16(98%),由Godrej Industries公司销售;/>16-98,由Sasol公司销售;/>6098,由Kao公司销售和/>16,由Aegis Chemical公司销售。
作为最特别适合在本发明中使用的硬脂醇,可使用例如以下列名称销售的那些:18,由Evonik Goldschmidt公司销售;/>18/98F和/>18/98P,由Ecogreen Oleochemicals公司销售;/>18,由Cognis公司销售;/>8098,由Kao公司销售;/>18,由Aegis Chemical公司销售;/>18-98,由Sasol公司销售和45,由Nihon Yushi公司销售。
作为最特别适合在本发明中使用的鲸蜡硬脂醇,可使用例如以下列名称销售的那些:68/50F和/>68/50P,由Ecogreen Oleochemicals公司销售;/>O OR和/>O OR Flakes,由Cognis公司销售;/>1618C50P,由Oxiteno公司销售;16-18EN,由Sasol公司销售;Alcohol Cetoestearilico 50/50,由IndustriaQuimica DelCentro公司销售;/>30CK,由New Japan Chemical公司销售;Cetylstearyl Alcohol50:50,由Evonik Goldschmidt公司销售;/>6850,由Kao公司销售;/>1618(50:50),由VVF公司销售和/>161850:50OR,由Godrej Industries公司销售。
有利地,相对于组合物的总重量计,饱和C12-C24脂肪醇的存在量范围为0.1wt.%-20wt.%,优选0.3wt.%-10wt.%,更优选0.5wt.%-8wt.%。
润肤剂
根据第一方面,本发明组合物包含至少一种润肤剂。
润肤剂可水合角蛋白基底,并且还提供光亮外观。润肤剂对于本领域技术人员是已知的。参见,例如国际化妆品成分词典和手册(International Cosmetic IngredientDictionary and Handbook)第4卷(第9版,2002年),更尤其是公开在第2930-2936页上的润肤剂。通过引用特此并入国际化妆品成分词典和手册(Intemational CosmeticIngredient Dictionary and Handbook)第4卷,第2930-2936页的公开内容。
可在本发明组合物中使用的润肤剂非限制性地包括多羟基化合物,例如生物糖胶、甘露糖、透明质酸、透明质酸钠、甘油;二醇醚,例如单丙二醇烷基(C1-C4)醚、一缩二丙二醇烷基(C1-C4)醚和二缩三丙二醇烷基(C1-C4)醚;二甘醇和三甘醇;巴西棕榈蜡;蜂蜡;小烛树蜡;地蜡;石蜡;米糠蜡;微晶蜡;聚乙烯蜡;矿物油;霍霍巴油;杏仁油;蓖麻油;芝麻油;角鲨烷;丁二醇二辛酸/二癸酸酯;牛油果树(butyrospermum parkii)果脂;及其混合物。
有利地,相对于组合物的总重量计,润肤剂的存在量范围为0.01wt.%-40wt.%,优选0.1wt.%-25wt.%,更优选3wt.%-20wt.%。
颜料
根据第一方面,本发明组合物包含至少1.5wt.%的有色颜料。
术语“有色颜料”应理解为表示有色的无机(矿物)颗粒或有机颗粒,其不溶于液体有机相,并且其意欲使组合物和/或由组合物产生的沉积物着色和/或不透明化。
颜料可选自矿物颜料、有机颜料和复合颜料(即,基于矿物材料和/或有机材料的颜料)。
颜料可选自单色颜料、色淀和具有光学效应的颜料(例如视角闪色颜料和珍珠母)。
矿物颜料可选自金属氧化物颜料,例如氧化铬、氧化铁(黑色、黄色、红色)、二氧化钛、氧化锌、氧化铈和氧化锆、氢氧化铬、锰紫、普鲁士蓝、群青、铁蓝、合成氟金云母、金属粉末(例如铝粉末和铜粉末)、及其混合物。
有机色淀是由染料附着到基底所形成的有机颜料。
色淀(其也称作有机颜料)可选自以下材料及其混合物:
-胭脂虫红;
-以下的有机颜料:偶氮染料、蒽醌染料、靛类染料、呫吨染料、芘染料、喹啉染料、三苯甲烷染料或荧烷染料。
在可特别提及的有机颜料之中是以下列名称已知的那些:D&C蓝色4号、D&C棕色1号、D&C绿色5号、D&C绿色6号、D&C橙色4号、D&C橙色5号、D&C橙色10号、D&C橙色11号、D&C红色6号、D&C红色7号、D&C红色17号、D&C红色21号、D&C红色22号、D&C红色27号、D&C红色28号、D&C红色30号、D&C红色31号、D&C红色33号、D&C红色34号、D&C红色36号、D&C紫色2号、D&C黄色7号、D&C黄色8号、D&C黄色10号、D&C黄色11号、FD&C蓝色1号、FD&C绿色3号、FD&C红色40号、FD&C黄色5号、FD&C黄色6号;
-有机色淀可以是酸性染料的不溶性钠盐、钾盐、钙盐、钡盐、铝盐、锆盐、锶盐或钛盐,所述酸性染料例如偶氮染料、蒽醌染料、靛类染料、呫吨染料、芘染料、喹啉染料、三苯甲烷染料或荧烷染料,这些染料可能包含至少一个羧酸基团或磺酸基团。
有机色淀也可负载在例如有机载体(例如松香或苯甲酸铝)上。
在有机色淀之中,可特别提及以下列名称已知的那些:D&C红色2号铝色淀、D&C红色3号铝色淀、D&C红色4号铝色淀、D&C红色6号铝色淀、D&C红色6号钡色淀、D&C红色6号钡/锶色淀、D&C红色6号锶色淀、D&C红色6号钾色淀、D&C红色7号铝色淀、D&C红色7号钡色淀、D&C红色7号钙色淀、D&C红色7号钙/锶色淀、D&C红色7号锆色淀、D&C红色8号钠色淀、D&C红色9号铝色淀、D&C红色9号钡色淀、D&C红色9号钡/锶色淀、D&C红色9号锆色淀、D&C红色10号钠色淀、D&C红色19号铝色淀、D&C红色19号钡色淀、D&C红色19号锆色淀、D&C红色21号铝色淀、D&C红色21号锆色淀、D&C红色22号铝色淀、D&C红色27号铝色淀、D&C红色27号铝/钛/锆色淀、D&C红色27号钡色淀、D&C红色27号钙色淀、D&C红色27号锆色淀、D&C红色28号铝色淀、D&C红色30号色淀、D&C红色31号钙色淀、D&C红色33号铝色淀、D&C红色34号钙色淀、D&C红色36号色淀、D&C红色40号铝色淀、D&C蓝色1号铝色淀、D&C绿色3号铝色淀、D&C橙色4号铝色淀、D&C橙色5号铝色淀、D&C橙色5号锆色淀、D&C橙色10号铝色淀、D&C橙色17号钡色淀、D&C黄色5号铝色淀、D&C黄色5号锆色淀、D&C黄色6号铝色淀、D&C黄色7号锆色淀、D&C黄色10号铝色淀、FD&C蓝色1号铝色淀、FD&C红色4号铝色淀、FD&C红色40号铝色淀、FD&C黄色5号铝色淀和FD&C黄色6号铝色淀。
颜料还可已经受氟化处理、疏水处理或亲水处理,优选疏水处理。
疏水处理剂可选自硅酮,例如聚甲基硅氧烷、聚二甲基硅氧烷、烷氧基硅烷和全氟烷基硅烷;脂肪酸,例如硬脂酸;金属皂,例如二肉豆蔻酸铝、氢化牛脂酰谷氨酸的铝盐、全氟烷基磷酸酯、全氟烷基硅烷、全氟烷基硅氮烷、聚六氟氧化丙烯、包含全氟烷基全氟聚醚基团的聚有机硅氧烷、以及氨基酸;N-酰基氨基酸或其盐;卵磷脂、三异硬脂酸钛酸异丙酯、及其混合物。
N-酰基氨基酸可包含含有8-22个碳原子的酰基,如,例如,2-乙基己酰基、己酰基、月桂酰基、肉豆蔻酰基、棕榈酰基、硬脂酰基或椰油酰基。这些化合物的盐可以是铝盐、镁盐、钙盐、锆盐、锌盐、钠盐或钾盐。氨基酸可以是例如赖氨酸、谷氨酸或丙氨酸。
以上引用的化合物中提及的术语“烷基”尤其表示含有1-30个碳原子、并优选含有5-16个碳原子的烷基。
经疏水处理的颜料尤其描述于专利申请EP-A-1 086 683中。
在一些优选实施方案中,本发明中使用的有色颜料选自经氟化处理的颜料、经亲水处理的颜料和经疏水处理的颜料。
更优选地,本发明中使用的有色颜料选自经以下者处理的颜料:三异硬脂酸异丙氧钛盐、三乙氧基甲硅烷基乙基聚二甲基硅氧乙基聚二甲基硅氧烷、或其混合物。
根据优选的实施方案,本发明中使用的有色颜料选自金属氧化物颜料、有机颜料、有机色淀、及其混合物。
有利地,相对于组合物的总重量计,颜料的存在量范围为1.5wt.%-20wt.%,优选3wt.%-15wt.%,更优选4wt.%-12wt.%。
水相
作为水包油乳液,本发明化妆品组合物包含连续水相。
所述水相包含水。
优选地,连续水相包含与水混溶(室温25℃下)的有机溶剂,例如具有2-20个碳原子、优选2-10个碳原子、且优选具有2-6个碳原子的二元醇,例如丙二醇、丁二醇、戊二醇、己二醇、辛甘醇、一缩二丙二醇、二甘醇;及其混合物。
有利地,所述水相的存在量范围为组合物总重量的40重量%-95重量%,优选50重量%-90重量%,且更优选55重量%-85重量%。
有利地,相对于本发明组合物的总重量计,水在该组合物中的存在量范围为40重量%-80重量%,优选45重量%-65重量%。
脂肪相
作为水包油乳液,本发明组合物包含至少一个分散脂肪相。
所述脂肪相优选包含至少一种油。
油可以是挥发性的或非挥发性的。
术语“油”表示在室温(25℃)和大气压(760mmHg)下呈液体的与水不混溶的非水性化合物。术语“非挥发性油”表示在室温和大气压下可保留在角蛋白材料上至少数小时并且特别具有小于10-3mmHg(0.13Pa)的蒸气压的油。非挥发性油还可定义为具有一定的蒸发速率,以致在前面限定的条件下,30分钟之后蒸发的量小于0.07mg/cm2。
这些油可以是植物、矿物或合成来源的。
所述油可选自烃化油、硅油或氟化油。
术语“基于烃的油”表示基本上由碳原子和氢原子以及任选的O原子和N原子形成或甚至由碳原子和氢原子以及任选的O原子和N原子构成,并且不含Si杂原子和F杂原子的油。此类油可含有醇、酯、醚、羧酸、胺和/或酰胺基团。
术语“硅油”表示含有至少一个硅原子,特别是含有Si-O基团的油。
术语“氟化油”表示含有至少一个氟原子的油。
相对于组合物的总重量计,油的存在量范围可例如为1.5重量%-50重量%,优选8重量%-45重量%,更优选16重量%-40重量%。
脂肪相还可包含在室温下为固体的固体脂肪化合物,例如牛油树脂。
有利地,相对于本发明组合物的总重量计,脂肪相的存在量范围为2重量%-50重量%,优选8重量%-45重量%,更优选16重量%-40重量%。
另外的化妆品活性成分
除了前文所定义的润肤剂和有色颜料之外,本发明组合物还可包含另外的化妆品活性成分。
作为化妆品活性成分的实例,可提及天然提取物;维生素,例如维生素A(视黄醇)、维生素E(生育酚)、维生素C(抗坏血酸)、维生素B5(泛醇)、维生素B3(烟酰胺)、以及所述维生素的衍生物(尤其酯)、及其混合物;尿素;咖啡因;水杨酸及其衍生物;α-羟基酸,例如乳酸或乙醇酸及其衍生物;防晒剂;来自藻类、真菌、植物、酵母和细菌的提取物;酶;作用于微循环的试剂;及其混合物。
在一些实施方案中,本发明组合物包含生育酚。
本领域技术人员容易基于根据本发明的组合物的最终用途来调节另外的化妆品活性成分的量。
另外的辅剂或添加剂
本发明组合物还可含有常规的化妆品辅剂或添加剂,例如香料、螯合剂(例如谷氨酸二乙酸四钠和EDTA二钠)、防腐剂(例如氯苯甘醚和苯氧乙醇)和杀菌剂、增稠剂(例如黄原胶、丙烯酰胺/丙烯酰二甲基牛磺酸钠共聚物、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物、羟丙基瓜尔胶);油增稠剂(例如聚氨酯、聚酰胺、乙基纤维素)、pH调节剂(例如三乙醇胺、柠檬酸和氢氧化钠)、填料(例如淀粉辛烯基琥珀酸铝和聚甲基倍半硅氧烷)、及其混合物。
本领域技术人员可选择另外的辅剂或添加剂的量,以便于不会不利地影响根据本发明的组合物的最终用途。
根据特别优选的实施方案,本发明提供呈水包油乳液形式的用于护理和/或化妆角蛋白材料的组合物,相对于组合物的总重量计,其包含:
(i)1wt.%-5wt.%的至少一种第一表面活性剂,其选自具有衍生自2-10个甘油单元的聚甘油部分和糖部分的聚甘油C10-C22脂肪酸酯;
(ii)0.5wt.%-10wt.%的至少一种第二表面活性剂,其选自甘油月桂酸酯、甘油油酸酯、甘油硬脂酸酯、甘油棕榈酸酯、聚山梨酯40、聚山梨酯60、聚山梨酯65、聚山梨酯80、聚山梨酯85、PEG-5失水山梨糖醇异硬脂酸酯、PEG-20失水山梨糖醇三异硬脂酸酯、PEG-20失水山梨糖醇异硬脂酸酯、PEG-40失水山梨糖醇七油酸酯、PEG-20失水山梨糖醇四油酸酯和PEG-20失水山梨糖醇三油酸酯、月桂醇聚醚-2、硬脂醇聚醚-2、癸醇聚醚-3、及其混合物;
(iii)0.5wt.%-8wt.%的至少一种饱和C12-C24脂肪醇,其选自鲸蜡醇、硬脂醇和鲸蜡硬脂醇;
(iv)3wt.%-20wt.%的至少一种润肤剂;和
(v)4wt.%-12wt.%的有色颜料,其选自金属氧化物颜料、有机颜料、有机色淀、及其混合物。
盖仑形式和方法
本发明组合物呈水包油乳液的形式。
根据本发明的组合物具有层状结构或层状结构化相。
术语“层状结构”或“层状结构化相”表示液晶结构、或者溶胀或非溶胀的结晶层状水合相,其具有平面对称性,包含平行布置并且由通常为水的液体介质分隔的若干两亲双层。如图1中所显示,在用光学显微镜在具有独特的光学效应的90°交叉偏振光下观察时,层状结构具有特征性光学效应。如果已观察到独特的光学效应,则意味着形成层状结构。
优选地,根据本发明的组合物可在室温下贮存20天之后保持层状结构,更优选地,根据本发明的组合物可在45℃下保持其配制物结构2个月。
本发明组合物可用于护理和/或化妆角蛋白材料。
根据第二方面,本发明提供用于护理和/或化妆角蛋白材料的非治疗性方法,其包括将根据本发明的第一方面的组合物施用于角蛋白材料。
以下实施例用来例示本发明,然而在本质上是非限制性的。
实施例
所使用的主要原材料及其商品名和供应商列于表1中。
表1
发明例1-8和比较例1-4
根据表2和表3中给出的量来制备发明例(IE.)1-8的组合物和比较例(CE.)1-4的组合物。各组分的量按含有其的组合物的总重量的重量%给出。
表2
表3
/>
制备方法:
取发明例1的组合物为例,如下制备以上列举的组合物:
1)用三辊轧机将红色7、红色28色淀、黄色6色淀和辛酸/癸酸甘油三酯碾磨成颜料糊;
2)将经碾磨的颜料糊和所有其它成分称量到主容器中,
3)将主容器加热至85℃;
4)在85℃下对基料(bulk)进行均质化,直到形成均匀的乳液;和
5)伴随轻柔刮壁(wall-scrapping)使基料冷却,直到35℃。
评估
对是否形成层状结构评估如下。
使用Leica DLMB显微镜在90°交叉偏振光下观察组合物,并拍摄显微照片。如果观察到层状结构的特征性光学效应,则意味着形成了层状结构。
图1显示了采用偏振光显微镜拍摄的发明例1(IE.1)的组合物的照片。
针对发明例2-8(Ex.2-8)的组合物也获得了类似的照片。
可见,发明例1-8(IE.1-8)的组合物中形成了层状结构。
针对比较例1-4(CE.1-4)的组合物没有获得类似的照片。
通过确定各组合物在室温(RT)和45℃下贮存之后保持层状结构的时间来评估组合物的稳定性。
通过如下测定覆盖率来评估施用发明例1-8的各组合物时的化妆效果,并且与两种水包油乳液形式的唇膏(商品1(YSL VernisàLèvres Pop Water,来自L'Oréal S.A.公司)和商品2(Perfect Diary Ultra Irresistible Light Everlasting Lip Veil,来自广州逸仙电子商务有限公司)进行比较。各组合物的覆盖率还与高覆盖率无水唇膏——商品3(Giorgio Armani Lis Maestro Intense Velvet color,来自L'Oréal S.A.公司)进行比较。
称量60mg的各样品并用经样品覆盖的指尖铺展在黑-白卡片上,该卡片呈棋盘状,并且具有按黑色或白色交替的3*2正方形单元,且各正方形的面积是2.5cm*2.5cm。
在37℃强制通风烘箱中干燥经样品覆盖的卡片10分钟,使用受Color iConrol软件控制的台式分光光度计(x·rite VS450,x·rite,Michigan,USA)来测量覆盖率,使用Lab色阶以六次重复来测量白色单元和黑色单元的颜色,并计算测量自被覆盖的白色方块和黑色方块的L值之间的差异并报告为配制物的覆盖率。较小的数值意味着较高的覆盖率。
通过以下方式来评估发明例1-8的各组合物的水合效果:邀请10名志愿者在其前臂和嘴唇上施用各组合物,并且对水合效果按1-5等级进行评分并取平均值,其中1是最低的水合感觉,5是最高的水合感觉。所有10名志愿者都报告了即刻水合的感觉。
以上制备的各组合物以及商品1-3的层状结构、稳定性、化妆效果(即,覆盖率)和水合效果的结果列于表4和表5中。
表4
表5
NA:未测试。
从表4中可见,发明例1-8的组合物具有层状结构,并且可提供良好的化妆效果(即,覆盖率)和水合效果。
Claims (14)
1.一种呈水包油乳液形式的用于护理和/或化妆角蛋白材料的组合物,其包含:
(i)至少一种第一表面活性剂,其选自具有衍生自2-10个甘油单元的聚甘油部分的聚甘油脂肪酸酯;
(ii)至少一种第二表面活性剂,其与如上所定义的所述聚甘油脂肪酸酯不同,并且在25℃的温度下其HLB<15;
(iii)至少一种饱和C12-C24脂肪醇;
(iv)至少一种润肤剂;和
(v)相对于所述组合物的总重量计,至少1.5wt.%的有色颜料。
2.根据权利要求1所述的组合物,其中所述第一表面活性剂选自具有衍生自2-10个甘油单元的聚甘油部分、含有或不含衍生自蔗糖、麦芽糖、葡萄糖、果糖或甲基葡萄糖的糖部分的聚甘油C10-C22脂肪酸酯。
3.根据权利要求1或2所述的组合物,其中所述第一表面活性剂选自具有衍生自2-10个甘油单元的聚甘油部分、含有或不含衍生自蔗糖、麦芽糖、葡萄糖、果糖或甲基葡萄糖的糖部分的聚甘油二硬脂酸酯,优选选自聚甘油-3二硬脂酸酯和甲基葡萄糖-聚甘油-3二硬脂酸酯。
4.根据权利要求1-3中任一项所述的组合物,其中相对于所述组合物的总重量计,所述第一表面活性剂的存在量范围为0.1wt.%-15wt.%,优选0.5wt.%-8wt.%,且更优选1wt.%-5wt.%。
5.根据权利要求1-4中任一项所述的组合物,其中所述第二表面活性剂选自甘油的C16-C22脂肪酸酯、氧乙烯化的失水山梨糖醇C12-C22脂肪酸酯和包含2-4个OE单元的氧乙烯化C12-C22脂肪醇。
6.根据权利要求1-5中任一项所述的组合物,其中所述第二表面活性剂选自甘油月桂酸酯、甘油油酸酯、甘油硬脂酸酯、甘油棕榈酸酯、失水山梨糖醇异硬脂酸酯、失水山梨糖醇月桂酸酯、失水山梨糖醇单硬脂酸酯、失水山梨糖醇硬脂酸酯、失水山梨糖醇倍半油酸酯、失水山梨糖醇三油酸酯、聚山梨酯60、聚山梨酯65、聚山梨酯80、聚山梨酯85、PEG-5失水山梨糖醇异硬脂酸酯、PEG-20失水山梨糖醇异硬脂酸酯、PEG-40失水山梨糖醇全油酸酯、PEG-20失水山梨糖醇四油酸酯、月桂醇聚醚-2、硬脂醇聚醚-2、癸醇聚醚-3、及其混合物。
7.根据权利要求1-6中任一项所述的组合物,其中相对于所述组合物的总重量计,所述第二表面活性剂的存在量范围为0.1wt.%-20wt.%,优选0.5wt.%-15wt.%,更优选0.5wt.%-10wt.%。
8.根据权利要求1-7中任一项所述的组合物,其中所述饱和C12-C24脂肪醇选自鲸蜡醇、硬脂醇、鲸蜡硬脂醇、肉豆蔻醇、月桂醇、十三烷醇、十五烷醇、十六烷醇、花生醇、山嵛醇、及其混合物。
9.根据权利要求1-8中任一项所述的组合物,其中相对于所述组合物的总重量计,所述饱和C12-C24脂肪醇的存在量范围为0.1wt.%-20wt.%,优选0.3wt.%-10wt.%,更优选0.5wt.%-8wt.%。
10.根据权利要求1-9中任一项所述的组合物,其中所述有色颜料选自金属氧化物颜料、有机颜料、有机色淀、及其混合物。
11.根据权利要求1-10中任一项所述的组合物,其中所述有色颜料选自经氟化处理的颜料、经亲水处理的颜料和经疏水处理的颜料。
12.根据权利要求1-11中任一项所述的组合物,其中相对于所述组合物的总重量计,所述颜料的存在量范围为1.5wt.%-20wt.%,优选3wt.%-15wt.%,更优选4wt.%-12wt.%。
13.根据权利要求1所述的组合物,相对于所述组合物的总重量计,其包含:
(i)1wt.%-5wt.%的至少一种第一表面活性剂,其选自具有衍生自2-10个甘油单元的聚甘油部分和糖部分的聚甘油C10-C22脂肪酸酯;
(ii)0.5wt.%-10wt.%的至少一种表面活性剂,其选自根据权利要求1-5中任一项所述的组成,其中所述第二表面活性剂选自甘油月桂酸酯、甘油油酸酯、甘油硬脂酸酯、甘油棕榈酸酯、失水山梨糖醇异硬脂酸酯、失水山梨糖醇月桂酸酯、失水山梨糖醇单硬脂酸酯、失水山梨糖醇硬脂酸酯、失水山梨糖醇倍半油酸酯、失水山梨糖醇三油酸酯、聚山梨酯60、聚山梨酯65、聚山梨酯80、聚山梨酯85、PEG-5失水山梨糖醇异硬脂酸酯、PEG-20失水山梨糖醇异硬脂酸酯、PEG-40失水山梨糖醇全油酸酯、PEG-20失水山梨糖醇四油酸酯、月桂醇聚醚-2、硬脂醇聚醚-2、癸醇聚醚-3、及其混合物、及其混合物;
(iii)0.5wt.%-8wt.%的至少一种饱和C12-C24脂肪醇,其选自鲸蜡醇、硬脂醇和鲸蜡硬脂醇;
(iv)3wt.%-20wt.%的至少一种润肤剂;和
(v)4wt.%-12wt.%的有色颜料,其选自金属氧化物颜料、有机颜料、有机色淀、及其混合物。
14.一种用于护理和/或化妆角蛋白材料的非治疗性方法,其包括将根据权利要求1-13中任一项所述的组合物施用于所述角蛋白材料。
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