CN116747459A - Multi-angle transport line rotary rack device and multi-angle flash radiotherapy irradiation method - Google Patents

Multi-angle transport line rotary rack device and multi-angle flash radiotherapy irradiation method Download PDF

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Publication number
CN116747459A
CN116747459A CN202310881331.XA CN202310881331A CN116747459A CN 116747459 A CN116747459 A CN 116747459A CN 202310881331 A CN202310881331 A CN 202310881331A CN 116747459 A CN116747459 A CN 116747459A
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China
Prior art keywords
angle
scanning mechanism
rotating
axis
transport
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CN202310881331.XA
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Chinese (zh)
Inventor
唐若
魏涛
何小中
杨柳
廖树清
袁建强
李劲
石金水
邓建军
王勐
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Institute of Fluid Physics of CAEP
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Institute of Fluid Physics of CAEP
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Priority to CN202310881331.XA priority Critical patent/CN116747459A/en
Publication of CN116747459A publication Critical patent/CN116747459A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A61N5/1081—Rotating beam systems with a specific mechanical construction, e.g. gantries
    • A61N5/1082—Rotating beam systems with a specific mechanical construction, e.g. gantries having multiple beam rotation axes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1087—Ions; Protons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1089—Electrons

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

The invention discloses a multi-angle transmission line rotating rack device and a multi-angle irradiation method, wherein the multi-angle transmission line rotating rack device comprises a rotating rack, at least two transmission mechanisms 4 are arranged on the rotating rack, and a beam incidence side of each transmission mechanism 4 is provided with a scanning mechanism for dispersing beams; the beam axis emitted by the scanning mechanism coincides with the entrance axis of each of the conveyor mechanisms 4. The beam current (proton or electron beam) emitting angle and position change are changed through the scanning mechanism, so that the beam current with a longitudinal time structure is discretized in a transverse space; by arranging at least two conveying mechanisms 4, the required time for covering 360-degree radiation angles is only 1/N under the condition of keeping the same angular velocity, wherein N is the number of the conveying mechanisms 4, the rotating time of the frame can be greatly reduced, and the treatment requirement of a FLASH mode is met.

Description

Multi-angle transport line rotary rack device and multi-angle flash radiotherapy irradiation method
Technical Field
The invention relates to the technical field of electron accelerators and nuclear medicine radiotherapy, in particular to a multi-angle transport line rotary rack device and a multi-angle flash radiotherapy irradiation method thereof.
Background
The existing rotating gantry device is basically only used in medical proton accelerators. The proton beam of 60-220 MeV is transported to the rotating center of the frame (focus of human body) from different angles, and the loss of the beam current to normal tissues of the human body can be greatly reduced under the same total dosage requirement. The rotating frame has a large and bulky structure (about 100 tons of a normal-temperature frame and about 20 tons of a superconducting frame), the rotating angular speed is small, and the single treatment time is more than 1 minute. In the electron accelerator, the electron linear accelerator is compact and small in structure, the whole accelerator device is directly arranged in the treatment head, and beam current transportation at different angles can be realized by changing the angle and the direction of the treatment head.
In the conventional proton, electron and X-ray (electron beam bombarding metal target) treatment mode, the requirement on the dosage rate is not high, the total dosage is mainly controlled, and the small angular velocity can meet the requirement of the conventional radiotherapy mode. The prior experimental study shows that the injection of high dose rate (tens to hundreds of Gy/s) radiation (including protons, electrons and X-rays) to tumor cells in a short time (hundreds of milliseconds) can kill the tumor cells to the maximum extent and realize the protection of normal cell tissues, and the mode called ultra-high dose rate radiotherapy (FLASH radiotherapy or FLASH radiotherapy) subverts the concept of traditional radiotherapy and has greatly developed.
The existing electron accelerator treatment head and proton accelerator rotating frame both adopt a mechanical moving structure, and can not realize FLASH mode treatment of multi-angle radiation in hundred millisecond time scale.
Disclosure of Invention
The invention aims to solve the technical problem that the existing electron accelerator treatment head and proton accelerator rotating frame both adopt a mechanical moving structure, and the FLASH mode treatment of multi-angle radiation in a hundred millisecond time scale cannot be realized.
The first object of the invention is to provide a multi-angle transport line rotary rack device, which comprises a rotary rack, wherein at least two transport mechanisms are arranged on the rotary rack, and a beam incidence side of each transport mechanism is provided with a scanning mechanism for dispersing beams; the beam axis emitted by the scanning mechanism is coincident with the inlet axis of each transport mechanism.
Under the condition of adopting the technical scheme, the beam current (proton or electron beam) emergent angle and position change are changed through the scanning mechanism, so that the beam current with a longitudinal time structure is discretized in a transverse space; by arranging at least two conveying mechanisms, the required time for covering 360-degree radiation angles is only 1/N under the condition of keeping the same angular velocity, wherein N is the number of the conveying mechanisms, the rotating time of the stand can be greatly reduced, and the treatment requirement of a FLASH mode is met.
As a possible design, the incident side of the beam of the scanning mechanism is provided with an accelerating mechanism, the distance between the inlet axis of each conveyor and the beam axis of the accelerating mechanism is R, the included angle between the inlet axis and the beam axis is gamma,l is the distance of beam drift, m. Each transport line is distributed symmetrically around the rotary frame in a discrete circumference with an angular spacing of 360 ° And N is exactly in one-to-one correspondence with the scattered beam spots generated by the rapid scanning device.
As a possible design, the distance R between the inlet axis of each of the conveyors and the beam axis of the acceleration mechanism is calculated from formula I,
wherein: l is the distance of beam drift, m; alpha is the beam emergent horizontal angle; beta is the beam exit angle perpendicular. The angle variation is controlled well, and the beam spot distribution which is discrete and circumferentially symmetrical can be realized.
As a possible design, the scanning mechanism is mainly composed of at least one set of electrode plates connected in an electrical path and voltage is rapidly adjustable, or guide magnets connected in an electrical path and magnetic field is rapidly adjustable.
As a possible design, all the beams emitted by the conveyor mechanism are converged on the rotation axis of the rotating frame.
As a possible design, the beams emitted by all the conveyor mechanisms are converged at the center of the rotating gantry.
As one possible design, the transport mechanism includes a plurality of magnets and/or X-ray generating targets.
The second object of the present invention is to provide a multi-angle flash radiation irradiation method based on the multi-angle line rotating rack device, comprising:
adjusting the angles of a plurality of conveying lines on the rotating frame in a preparation state;
the scanning mechanism is quickly adjusted, so that the emission direction and the position of the beam passing through the scanning mechanism are changed, the beam with a longitudinal time structure is discretized in a transverse space, and the discrete beam angles are in one-to-one correspondence with the transport lines;
the beam flows are transmitted by the transmission line and then are converged at the center of the rotating frame, or the beam flows are converged after being converted into X-rays at the tail end of the transmission line, so that multi-angle irradiation is realized.
Under the condition of adopting the technical scheme, the requirement of covering 360-degree radiation angle can be met by only adjusting a smaller angle on the rotating frame, namely, the time required by adjustment is greatly reduced when the same radiation angle is reached, and the beam flow reaching the treatment part in unit time is increased through a plurality of conveying mechanisms, so that the FLASH mode treatment requirement is met.
As one possible design, the transport mechanisms are circularly distributed when the irradiation angle is less than 360 degrees; when the conveying mechanisms are only circularly distributed, the conveying mechanisms are not required to be circularly and symmetrically distributed, and the treatment requirements of a FLASH mode can be met.
As one possible design, when the angle value of the irradiation angle is smaller than the number of beam lines of the transport mechanism; by changing the distribution angle between the conveying mechanisms and not rotating the rotating frame, the FLASH treatment mode of multi-angle radiation can be realized.
The beneficial effects of the invention are as follows: the multi-angle transmission line rotating rack device disclosed by the invention can realize beam angle conversion in microsecond time scale and realize FLASH mode treatment of multi-angle radiation. According to the actual irradiation angle, the beam angle conversion can be carried out in various modes, so as to realize the FLASH mode treatment of multi-angle radiation.
Drawings
In order to more clearly illustrate the technical solutions of the exemplary embodiments of the present invention, the drawings that are needed in the examples will be briefly described below, it being understood that the following drawings only illustrate some examples of the present invention and therefore should not be considered as limiting the scope, and that other related drawings may be obtained from these drawings without inventive effort for a person skilled in the art. In the drawings:
FIG. 1 is a schematic view of a conveyor mechanism and a rotating frame in a multi-angle conveyor line rotating frame apparatus in accordance with an embodiment of the present invention;
fig. 2 is a schematic view of a conventional conveyor mechanism.
In the drawings, the reference numerals and corresponding part names:
1-dipolar magnet, 2-scanning mechanism beam, 3-rotating frame, 4-conveying mechanism.
Detailed Description
For the purpose of making apparent the objects, technical solutions and advantages of the present invention, the present invention will be further described in detail with reference to the following examples and the accompanying drawings, wherein the exemplary embodiments of the present invention and the descriptions thereof are for illustrating the present invention only and are not to be construed as limiting the present invention.
Because the FLASH treatment mode has the advantages that the radiation (including protons, electrons and X rays) with high dose rate (tens to hundreds of Gy/s) is injected into tumor cells in a short time (hundreds of milliseconds), the tumor cells can be killed to the maximum extent and normal cell tissues can be protected, so the FLASH treatment mode has great development prospect, but in the device for accelerating the radiation beam flow, the existing electron accelerator adopts a single conveying mechanism 4, the direction of the beam flow is not deflected before the beam flow enters the conveying mechanism 4, the position change of the beam flow reaching a treatment part is realized only by the mechanical adjustment of the rotating frame angle, and the mode mainly has the following problems: 1. the single conveying mechanism 4 has low conveying dosage rate, and can not meet the requirement of a FLASH treatment mode on the dosage rate; 2. because the rotating speed of the existing rotating frame is low, FLASH mode treatment of multi-angle radiation in millisecond time scale cannot be realized.
In order to solve the above problems of the existing electron accelerator, the present inventors found that by providing a plurality of transport mechanisms 4 and distributing the plurality of transport mechanisms 4 on a rotating frame, the beam emitted from the plurality of transport mechanisms 4 is mixed at one point to act on the treatment site, the requirement of the dose rate is not satisfied, and the rotating frame only needs 1/N (N is the number of transport mechanisms 4) of time to achieve the requirement of the angle radiation covering 360 ° range, thereby satisfying the FLASH treatment mode.
The embodiment discloses a multi-angle conveying line rotating rack 3 device. As shown in fig. 1, the multi-angle transport line rotating rack 3 device comprises a rotating rack 3, wherein at least two transport mechanisms 4 are arranged on the rotating rack 3, and a beam incidence side of each transport mechanism 4 is provided with a scanning mechanism for dispersing beams; the beam axis emitted by the scanning mechanism coincides with the entrance axis of each of the conveyor mechanisms 4.
The transport mechanism 4 is arranged on the rotating frame 3, so that the specific position of the beam irradiated on the treatment part can be adjusted by adjusting the angle of the rotating frame 3; because at least two conveying mechanisms 4 are adopted, the scanning mechanism is mainly used for changing the emergent angle and position change of the beam, so that the beam with a longitudinal time structure is discretized in a transverse space and reaches each conveying mechanism 4 to be conveyed; because the number of the conveying mechanisms 4 is at least two, the rotating frame 3 can cover the radiation angle requirement of 360 degrees through small-angle rapid rotation, and the rapid switching of the emergence angle is realized, so that the FLASH treatment mode of multi-angle radiation is completed.
It should be noted that: each conveyor 4 constitutes a conveyor line.
In one possible implementation manner, the scanning mechanism mainly changes the change and position of the emergent angle of the beam (proton or electron beam) to realize the discretization of the beam with a longitudinal time structure in the transverse space, so that the scanning mechanism can be formed by at least one electrode plate or guide magnet, the electrode plate and the guide magnet are connected into an electric path, and the discretization of the beam with the longitudinal time structure in the transverse space is realized through the change of the voltage on the electrode plate or the magnetic field of the guide magnet.
It should be noted that: the electrode plates or the guide magnets need to be formed in a cylindrical shape or in a cylindrical shape, and as shown in fig. 1, the beam is injected from one end of the cylindrical shape and is injected from the other end.
Wherein the change of the emergent angle of the beam current (proton or electron beam) mainly comprises the change of the horizontal angle alpha and the change of the vertical angle beta, and the position deviation (the horizontal position deviation isVertical position deviation amount->). The angle change is controlled well, the beam spot distribution which is discrete and circumferentially symmetrical can be realized, and the distance between the beam spot and the axis is +.>The angular spacing of the center of each beam spot is 360 ° And N, N is the number of the conveying mechanisms 4.
In one possible embodiment, each of the transport mechanisms 4 is identical in specific construction to the transport mechanism 4 in the existing rotating gantry 3 apparatus, as shown in fig. 2, and functions to deflect, focus, and transport the beam and direct the exit direction toward the center of rotation of the rotating gantry 3.
In the conveying mechanism 4, the inlet axis of the single conveying mechanism 4 is not coincident with the beam axis of the accelerating mechanism, the distance is R, and the inlet axis and the beam axis form an angle gammaThis ensures that the rapidly scanned beam coincides with the entrance axis of the conveyor 4.
In one possible embodiment, the rotating gantry 3 is mainly used to adjust the specific position of the beam impinging on the treatment site and to support the conveyor mechanism 4, so that on the one hand, the structural rigidity is ensured, and the supported conveyor mechanism 4 is ensured to be stable and not deformed; on the other hand, the mass center of the rotating frame 3 is adjusted to a rotating shaft, particularly, the adjustment of the beam angle emitted by the conveying mechanism 4 is realized through a counterweight mode, and the adjustment of the beam angle is realized through mechanical rotation, so that the specific distribution mode of the conveying mechanism 4 relates to the adjustment of the angle, and further the adjustment time is related. The structure of the rotating frame 3 is the same as that of the rotating frame 3 in the conventional rotating frame 3 device, and will not be described in detail here. The distribution of the conveyor 4 may be as follows: at least two conveying mechanisms 4 are arranged on the rotating frame 3 and distributed circularly around the circumference of the rotating frame 3, and beams emitted by the conveying mechanisms 4 are converged on the rotating shaft of the rotating frame 3.
As a preferred embodiment, at least two conveyor means 4 are arranged on the rotating frame 3 and are distributed circularly symmetrically around the circumference of the rotating frame 3. Angular spacing of 360 ° And N is exactly in one-to-one correspondence with the scattered beam spots generated by the rapid scanning device.
In some application scenes, the irradiation adjusting angle is smaller than 360 degrees, the conveying mechanisms 4 are not necessarily distributed symmetrically in circumference, and can also meet the FLASH treatment mode, and the structure accords with the characteristics of the invention.
In some application scenarios, when the angle value of the irradiation adjusting angle is smaller than the number of the conveying mechanisms 4, the rotating frame 3 can not rotate, and the FLASH treatment mode of multi-angle radiation can be realized only by changing the distribution angle among the conveying mechanisms 4 on a mechanical structure, and the structure also accords with the characteristics of the invention.
Under the condition of keeping the same angular velocity, the time required by the multi-angle transport line rotating frame 3 device for covering the 360-degree range of angle radiation is only 1/N of the existing rotating frame 3 device, so that the rotating time of the rotating frame 3 can be greatly reduced, and the treatment requirement of a FLASH mode is met.
When the multi-angle transmission line rotary rack 3 device disclosed in the embodiment of the invention is specifically used, as the rotary rack 3 and the transmission mechanism 4 are connected together, and the scanning mechanism is generally installed on the ground and does not rotate together with the transmission mechanism 4 and the rotary rack 3, the dispersion and the angular rotation of beam current are realized only through the change of an electrode plate or a guide magnet (namely the scanning mechanism), and the angle of the beam current is matched with the angle of the transmission line.
The foregoing description of the embodiments has been provided for the purpose of illustrating the general principles of the invention, and is not meant to limit the scope of the invention, but to limit the invention to the particular embodiments, and any modifications, equivalents, improvements, etc. that fall within the spirit and principles of the invention are intended to be included within the scope of the invention.

Claims (9)

1. The multi-angle transport line rotating rack device comprises a rotating rack and is characterized in that at least two transport mechanisms are arranged on the rotating rack, and a beam incidence side of each transport mechanism is provided with a scanning mechanism for dispersing beams; the beam axis emitted by the scanning mechanism is coincident with the inlet axis of each transport mechanism.
2. The multi-angle line rotating gantry apparatus of claim 1, wherein an acceleration mechanism is disposed on an incident side of a beam of the scanning mechanism, a distance between an inlet axis of each of the conveyors and a beam axis of the acceleration mechanism is R, an angle between the inlet axis and the beam axis is γ,l is the distance of beam drift, m.
3. The multi-angle line rotating gantry apparatus of claim 2, wherein a distance R between an inlet axis of each of said conveyors and a beam axis of said acceleration mechanism is calculated from formula I,
wherein: l is the distance of beam drift, m; alpha is the beam emergent horizontal angle; beta is the beam exit angle perpendicular.
4. The multi-angle line rotating rack device according to claim 1, wherein the scanning mechanism is mainly composed of at least one set of electrode plates connected in an electrical path and voltage-fast adjustable, or guide magnets connected in an electrical path and magnetic field-fast adjustable.
5. The multi-angle line rotating gantry apparatus of claim 1 wherein all of the beams emitted by the conveyor mechanism are merged on the axis of rotation of the rotating gantry.
6. The multi-angle line rotating gantry apparatus of claim 5, wherein the beams of all of the conveyor mechanisms meet at a center of the rotating gantry.
7. The multi-angle line rotating gantry apparatus of claim 1, wherein the conveyor mechanism comprises a plurality of magnets and/or X-ray generating targets.
8. A multi-angle flash radiation therapy irradiation method based on the multi-angle line rotary rack device according to any one of claims 1 to 7, characterized by comprising:
adjusting the angles of a plurality of conveying lines on the rotating frame in a preparation state;
the scanning mechanism is quickly adjusted, so that the emission direction and the position of the beam passing through the scanning mechanism are changed, the beam with a longitudinal time structure is discretized in a transverse space, and the discrete beam angles are in one-to-one correspondence with the transport lines;
the beam flows are transmitted by the transmission line and then are converged at the center of the rotating frame, or the beam flows are converged after being converted into X-rays at the tail end of the transmission line, so that multi-angle irradiation is realized.
9. A method of multi-angle flash radiation therapy irradiation based on the multi-angle line rotating gantry apparatus of any one of claims 1-7, wherein the conveyor means are circularly distributed when the irradiation angle is less than 360 degrees.
The scanning mechanism is quickly adjusted, so that the emission direction and the position of the beam passing through the scanning mechanism are changed, and the beam with a longitudinal time structure is discretized in a transverse space; and the discrete beam angles are in one-to-one correspondence with the transport lines.
The beam flows are transmitted by the transmission line and then are converged at the center of the rotating frame, or the beam flows are converged after being converted into X-rays at the tail end of the transmission line, so that multi-angle irradiation is realized.
CN202310881331.XA 2023-07-18 2023-07-18 Multi-angle transport line rotary rack device and multi-angle flash radiotherapy irradiation method Pending CN116747459A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310881331.XA CN116747459A (en) 2023-07-18 2023-07-18 Multi-angle transport line rotary rack device and multi-angle flash radiotherapy irradiation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310881331.XA CN116747459A (en) 2023-07-18 2023-07-18 Multi-angle transport line rotary rack device and multi-angle flash radiotherapy irradiation method

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CN116747459A true CN116747459A (en) 2023-09-15

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