CN116747387A

CN116747387A - Quantitative preparation device for medicament

Info

Publication number: CN116747387A
Application number: CN202310902752.6A
Authority: CN
Inventors: 李黎; 朱亚宁; 史先鹏; 杨同斐
Original assignee: Shaanxi Provincial People's Hospital Shaanxi Provincial Institute Of Clinical Medicine
Current assignee: Shaanxi Provincial People's Hospital Shaanxi Provincial Institute Of Clinical Medicine
Priority date: 2023-07-21
Filing date: 2023-07-21
Publication date: 2023-09-15

Abstract

The invention discloses a quantitative medicament configuration device, which comprises at least two medicament reservoirs, wherein the metering regulator is provided with a communication part corresponding to each medicament reservoir, the communication part is communicated with a mixed medicament temporary storage cavity arranged in the metering regulator, and the communication part is of a pressed open structure; the metering regulator further comprises a dosage regulating element extending to the plunger end of the drug reservoir, the dosage regulating element comprising a fixed datum ring-fixed around the drug reservoir, and a pressing part axially movable towards the fixed datum, the pressing part pressing the plunger; the trigger piece is driven by the driving piece to push the medicine in the mixed medicine temporary storage cavity to be injected to the direction of the needle head. According to the invention, a plurality of medicine accommodating cavities are integrated on the same injector, and after a plurality of different medicines are communicated into the mixed medicine temporary storage cavity, different injection amounts are set, and different medicines are mixed into the cavity.

Description

Quantitative preparation device for medicament

Technical Field

The invention discloses a quantitative preparation device for medicines, and relates to the technical field of quantitative preparation of medicines.

Background

There are a variety of automatic injection devices available in the prior art that are suitable for long-term injection to treat patients suffering from disease. For example diabetes treatment: for some diabetics, particularly those who require simultaneous administration of insulin and an insulin sensitizer (e.g., insulin analogue), it may be desirable to mix the two drugs for injection.

In some cases, it may also be desirable for the patient to mix multiple antibiotics together by himself for injection to achieve a broader spectrum of antibacterial action or against different types of pathogens.

In other cases, particularly for patients requiring long-term intravenous nutritional support, it may be desirable to mix multiple nutritional ingredients, vitamins, and drugs together for injection. Thus, the nutritional requirements of patients can be met, and the medication process is simplified.

In the treatment of some autoimmune diseases, it may also be desirable to mix injections of multiple immunomodulatory drugs. These drugs can co-regulate the immune system through different mechanisms of action to control disease progression.

However, various types of metering devices in the prior art typically require different drug reservoirs. Such as pre-filled syringes, insulin pens and auto-injectors. Thus, for situations where multiple medicaments need to be mixed, conventional metered dose injection devices may not be practical. As mentioned above, some diseases requiring long-term self-injection by the patient cannot be applied with a simple syringe, and thus devices or means for mixing a drug into a syringe such as the one described in patent (CN 103445812B) are not suitable.

Summary of the invention

The invention aims to provide a quantitative preparation device for medicines, which solves the problem that a portable injector in the prior art cannot mix multiple medicines for injection.

In order to achieve the technical purpose and the technical effect, the invention is realized by the following technical scheme:

the utility model provides a medicament ration configuration device, includes the medicine reservoir who deposits the medicine, the medicine reservoir connects the internal restriction have the piston, with the plunger of piston body coupling, the plunger is responsible for promoting the piston, extrudes the medicine from the reservoir, and the promotion direction intercommunication has the syringe needle that is used for the injection, the syringe needle with medicine reservoir intercommunication area is equipped with dose regulator, the dose regulator other end is equipped with the trigger, the trigger is connected with the driving piece. The metering regulator is provided with a communication part corresponding to each medicine container, the communication part is communicated with a mixed medicine temporary storage cavity arranged in the metering regulator, and the communication part is of a pressed open structure;

the metering regulator further comprises a dosage regulating element extending to the plunger end of the drug reservoir, the dosage regulating element comprising a fixed datum ring-fixed around the drug reservoir, and a pressing part axially movable towards the fixed datum, the pressing part pressing the plunger;

the trigger piece is driven by the driving piece to push the medicine in the mixed medicine temporary storage cavity to be injected to the direction of the needle head.

Further, the pressure applying part is connected with a displacement display, and the displacement display is provided with a displacement detecting part for monitoring the displacement of the pressure applying part and displays the displacement in real time in the displacement display;

the number of the displacement detection parts is the same as that of the pressing parts, and the displacement detection parts and the pressing parts are matched with each other.

Further, the fixed reference further comprises a limiting piece for limiting the axial movement of the pressing part, the fixed position of the limiting piece on the fixed reference is pre-regulated according to various doses before injection, and the pressing part stops pushing injection after axially moving to the limiting piece;

the number of the limiting pieces is the same as that of the pressing parts, and the limiting pieces and the pressing parts are matched with each other.

Further, the fixed reference is a shell of the injector, the pressing part comprises push rods fixedly connected with the plungers, the number of the push rods is matched with that of the plungers, the other ends of all the push rods are fixed with a pushed part, and the pushed part is provided with a toggle switch;

the limiting piece is a jacking block capable of sliding along the axial direction, a clamping and fixing part connected with an elastic piece is arranged on the outer side of the shell, and the clamping and fixing part is clamped and fixed with the shell;

the toggle switch applies axial limitation to the push rod when not stressed, and when the plunger is limited by the limiting piece, a reverse supporting force is generated, and the supporting force toggles the toggle switch to be opened and loses limitation to the push rod.

Furthermore, the limiting piece is replaced by an adjusting ring which is fixed outside the shell in a ring sleeve mode and can axially rotate, only one adjusting ring is arranged, the limiting piece comprises a contact part which can be bounced, the contact part is relatively fixed with the adjusting ring after bounced, and the contact part is driven by the adjusting ring to axially move.

Further, the limiting piece comprises a compressible part with one end arranged outside the fixing range of the ring sleeve ring, and the other end is connected with the contact part through a lever structure;

the contact part is fixed with the adjusting ring in a friction way, and the axial movement of the adjusting ring directly drives the limiting piece fixed relative to the adjusting ring to move.

Further, threads are arranged in the adjusting ring, and the contact part is provided with a thread surface matched with the contact part;

the limiting piece comprises a compressible part with one end arranged outside the fixing range of the ring sleeve, and the other end is connected with the contact part through a lever structure;

after the two parts are in threaded engagement, the rotation of the adjusting ring is converted into the axial movement of the limiting piece.

Further, the pressing part is replaced by an electric control pushing piece capable of presetting the process.

Further, the displacement detection part is an optical sensor, and the displacement display further comprises a display panel in real-time communication with the displacement detection part, wherein the display panel displays displacement;

the displacement amount is converted into a preset injection amount according to the diameter of the drug reservoir.

Further, the displacement display is replaced by scale marks marked on the side of the limiting piece.

The beneficial effects are that:

according to the invention, a plurality of medicine accommodating cavities are integrated on the same injector, and after a plurality of different medicines are communicated into the mixed medicine temporary storage cavity, different injection amounts are set, and different medicines are mixed into the cavity. The medicines in the cavities are fully mixed according to the proportion, and then the triggering piece is triggered, so that the mixed medicines are injected into the body.

On the one hand, the portable injection device effectively realizes portable injection when a plurality of medicines are mixed, and can be injected at any time by using the existing injection modes (such as a hidden needle) such as an injection pen and the like. On the other hand, the injection quantity is controlled for different medicines respectively, the proportion can be controlled accurately, and the purpose of portable injection is completely realized.

Of course, it is not necessary for any one product to practice the invention to achieve all of the advantages set forth above at the same time.

Drawings

FIG. 1 is a diagram of a device for quantitative preparation of a pharmaceutical agent according to an embodiment of the present invention;

FIG. 2 is an exploded view of a device for dosing and dispensing a pharmaceutical agent according to an embodiment of the present invention;

FIG. 3 is a schematic diagram of a toggle switch according to an embodiment of the present invention;

FIG. 4 is a schematic view of another state of the toggle switch according to the embodiment of the present invention;

FIG. 5 is a schematic diagram illustrating connection of a connection portion according to an embodiment of the present invention;

FIG. 6 is a diagram showing a contact condition between an adjusting ring and a contact portion according to an embodiment of the present invention;

in the accompanying drawings:

1-fixed datum, 2-pressing part, 3-plunger, 4-needle, 5-displacement display, 6-medicine reservoir, 101-limiting piece, 102-groove, 103-pressable part, 104-contact part, 105-annular sleeve, 301-pushed part, 302-push rod, 303-toggle switch, 601-communication part and 602-mixed medicine temporary storage cavity.

Detailed Description

Based on the construction of the prior art portable syringes, the applicant has modified them to have a plurality of devices which can accommodate different medicaments. The design can realize the functions of multi-drug mixing and quantitative injection.

The applicant has provided a medicament reservoir 6, a plurality of individual medicament reservoirs 6 each containing a different medicament, the specific number being selectable as required. To achieve the target function, a mechanism capable of mixing and delivering three drugs in a predetermined ratio to the needle 4 is required.

In order to achieve the foregoing function, the applicant discloses in this embodiment a medicament dosing device comprising a medicament reservoir 6 for storing medicament, wherein a piston is limited in the connection of the medicament reservoir 6, a plunger 3 integrally connected with the piston, the plunger 3 is responsible for pushing the piston to extrude medicament from the medicament reservoir 6, a needle 4 for injection is communicated with the pushing direction, a dose regulator is arranged in the communication area between the needle 4 and the medicament reservoir 6, a trigger is arranged at the other end of the dose regulator, and the trigger is connected with a driving member.

The drug reservoir 6 is one of the core components of the present embodiment, and its main function is to store the drug to be injected. In one embodiment, the drug reservoir 6 may be a cylindrical container having at least two separate drug-containing chambers within it, each for storing a drug. When the piston and plunger 3 are driven by the drive member and moved forward, the medicament is expelled from the medicament reservoir 6 and is injected through the needle 4.

The trigger is another important component of the present embodiment, which functions to activate the driver, thereby driving the piston and plunger 3 to squeeze the medicament. The implementation of the flip-flop may be varied according to different embodiments.

In one embodiment, the trigger is a push button trigger, and the user presses the push button when in use, and the trigger transmits power to the piston and the plunger 3 through the connecting driving piece, so that the injection of the medicine is realized. The embodiment is simple to operate and convenient for a user to quickly inject.

In another embodiment, the trigger is a pull rod type trigger, and a user pulls the pull rod when in use, and the trigger transmits power to the piston and the plunger 3 through the connecting driving piece, so that the injection of the medicine is realized. Such an embodiment has a high mechanical efficiency and is suitable for use in situations where a high force injection is required.

The medicine storage 6 is at least two, the metering regulator is provided with a communication part 601 corresponding to each medicine storage 6, the communication part 601 is communicated with a mixed medicine temporary storage cavity 602 arranged in the metering regulator, and the communication part 601 is of a pressed open structure.

The mixed drug temporary storage chamber 602 is a key component of the present embodiment and is primarily used to temporarily store and mix drugs after they are expelled from the respective drug reservoirs 6. In this embodiment, the mixed drug temporary storage chamber 602 may be a small container that can hold the drugs squeezed from the different drug reservoirs 6 therein and mix them into a uniform drug solution. When mixing is completed, the drug solution is injected through needle 4.

The pressurized open structure means that the communication part 601 is opened when a certain pressure is applied, allowing the medicine to enter the mixed medicine temporary storage chamber 602 from the medicine reservoir 6. The design can ensure that the medicines can be mixed and injected after the proportion of the medicines is regulated by the metering regulator.

In one embodiment, the pressurized open structure is a spring loaded one-way valve, which opens when the pressure applied by the piston exceeds the preset valve opening pressure of the spring, and the drug smoothly enters the mixed drug temporary storage cavity 602. This design ensures that the drug enters the mixed drug temporary storage chamber 602 under the proper pressure, thereby achieving accurate drug ratio control.

The metering regulator further comprises a dose regulating member extending to the end of the plunger 3 of the drug reservoir 6, the dose regulating member comprising a fixed reference 1 which is annularly fixed around the drug reservoir 6, and a pressing portion 2 which is movable in the axial direction of the fixed reference 1, the pressing portion 2 pressing the plunger 3.

The fixed reference 1 is an important part of the dose setting member, and is mainly used for providing a reference point for the pressing portion 2 so as to accurately control the displacement of the pressing portion 2. The fixed reference 1 may be a ring-shaped structure fastened around the medicament reservoir 6, kept stationary.

The pressing portion 2 is another important part of the dose setting member, and its main function is to apply different degrees of pressure to the plunger 3 according to a preset medicine ratio. In the present embodiment, the pressing portion 2 is movable in the axial direction of the fixed reference 1. When the pressing portion 2 applies pressure to the plunger 3, the plunger 3 pushes the piston, squeezing the drug out of the drug reservoir 6. By adjusting the position of the pressure applying portion 2, accurate control of the medicament in the different medicament reservoirs 6 can be achieved, thereby achieving a preset medicament ratio.

The trigger is driven by the driving member to push the medicine in the mixed medicine temporary storage cavity 602 to be injected to the direction of the needle 4.

In some embodiments, the user may set the injection amount and mixing ratio of each drug through the interface. The electronic control system adjusts the micropump and valve system according to the set point to deliver each drug in proportion to the mixing chamber or specially designed needle 4. After mixing in the mixing chamber or needle 4, the drug is injected into the patient through the needle 4 in a set total dose.

Specifically, the functions can be realized by combining the micro pump, the valve system and other devices, and the micro pump and the valve can accurately regulate the medicine flow of each medicine reservoir 6 by combining the electronic control system, so that the quantitative injection can be realized. And pressure sensors and flow meters, accurate control of the injection volume can be achieved by monitoring the pressure and flow rate of each drug reservoir 6 in real time.

The electronic control system is used for realizing control, a user can set the injection quantity and the mixing proportion of each medicine through a touch screen or other interfaces, and the electronic control system can adjust the micropump, the valve, the pressure sensor and the flowmeter according to set values, so that accurate dosage control is realized.

In some cases, the device may be an improvement based on an insulin injection pen. The trigger of the injection pen is one of its core components, responsible for controlling the release of insulin.

Insulin injection pen triggers are typically composed of several parts:

the pushrod 302: the push rod 302 is an elongated metal or plastic member that is used to push the piston in the insulin reservoir forward.

A piston rod: the piston rod connects the pushrod 302 and the piston, transmitting the motion of the pushrod 302 to the piston.

And (3) a spring: the spring is used for storing energy, and when the trigger is pressed down, the spring is compressed to store energy; when the trigger is released, the spring releases energy, pushing the push rod 302 forward.

Dose adjuster: the dose regulator is used to set the desired insulin dose, typically of a knob or push button design, allowing the user to precisely adjust the dose per injection.

Triggering a button: a trigger button is located at the end of the injection pen for initiating the injection process. When the user presses the trigger button, the spring releases energy, pushing the push rod 302 forward.

Working principle:

the trigger of the insulin injection pen works as follows:

the user sets the desired insulin dose by rotating the dose adjuster or pressing a button. The dose adjuster is typically associated with the distance of movement of the push rod 302 to control the amount of insulin per injection.

When the user is ready to make an injection, the needle 4 is inserted into the skin and the trigger button is pressed. At this point, the spring is compressed, storing energy.

When the trigger button is released, the spring rapidly releases the stored energy, pushing the push rod 302 forward. The pushrod 302 transmits motion to the piston through the piston rod.

As the plunger moves forward, insulin is expressed from the reservoir and injected into the patient through the needle 4.

When the injection is completed, the user may reset the dose adjuster to zero, ready for the next injection.

The design of the insulin injection pen trigger allows the patient to easily perform insulin injections while ensuring accurate and reliable dose control.

This basic principle can be applied in the present invention.

In order to more clearly describe the technical scheme of the embodiment of the present invention, the embodiment of the present invention will be described in detail below with reference to the accompanying drawings.

The first embodiment may refer to fig. 1, and this implementation includes all the structures of the apparatus in the foregoing embodiment, but is specifically a straight cylindrical structure as a whole. The internal structure of the explosive structure can be better understood in conjunction with fig. 2.

The condition in which the medicine reservoir 6 communicates with the communication portion 601 can be understood with reference to fig. 5. The unidirectional flow mechanism inside the communication portion 601 after communication keeps the medicine from flowing into the mixed medicine temporary storage cavity 602.

In this embodiment, the pressure applying portion 2 is connected to a displacement display 5, and the displacement display 5 is provided with a displacement detecting portion for monitoring the displacement of the pressure applying portion 2, and displays the displacement thereof in real time in the displacement display 5; the number of the displacement detection parts is the same as that of the pressing parts 2, and the displacement detection parts are matched with each other.

In combination with the foregoing, since the portion for the preset dose cannot be made to restrict the injection or bolus into the mixed drug temporary storage chamber 602 at the time of injection after the preset dose, in this embodiment, the fixed reference 1 further includes a stopper 101 for restricting the axial movement of the pressing portion 2, the fixed position of the stopper 101 on the fixed reference 1 is pre-adjusted according to various doses before the injection, and the pressing portion 2 stops the bolus after the axial movement to the stopper 101.

In this embodiment, as shown in the structure of fig. 1-2, the limiting member 101 is a top block that can be adjusted in position in the recess 102.

In this embodiment, the fixed reference 1 is a housing of the injector, the pressing portion 2 includes push rods 302 fixedly connected to the plungers 3, the number of the push rods 302 matches that of the plungers 3, the other ends of all the push rods 302 are fixed to a pushed portion 301, and the pushed portion 301 is provided with a toggle switch 303.

The limiting part 101 is a top block capable of sliding along the axial direction, a clamping part connected with an elastic part is arranged on the outer side of the shell, and the clamping part is clamped and fixed with the shell.

The toggle switch 303 applies an axial limitation to the push rod 302 when not under force, and when the plunger 3 is limited by the limiting member 101, a reverse supporting force is generated, and the supporting force toggles the toggle switch 303 to open and loses limitation to the push rod 302.

The specific working principle can be referred to in fig. 3-4, when the medicine is needed to be injected into the mixed medicine temporary storage cavity 602, the spring at the tail end is supported, the rod body is not pressed any more, the locking is released after the rod body is opened, and the function that the medicine is injected into the mixed medicine temporary storage cavity 602 is realized.

The number of the limiting pieces 101 is the same as that of the pressing parts 2, and the limiting pieces are matched with each other.

In the second embodiment, the limiting member 101 is replaced by an adjusting ring with a ring sleeve 105 fixed outside the casing and capable of rotating axially, only one adjusting ring is provided, the limiting member 101 comprises a contact portion 104 capable of being sprung, the contact portion 104 is fixed relative to the adjusting ring after being sprung, and the adjusting ring is driven to move axially.

The limiting piece 101 comprises a compressible portion 103 with one end arranged outside the loop 105 loop fixing range, and the other end is connected with the contact portion 104 through a lever structure. The contact part 104 is fixed with the adjusting ring in a friction way, and the axial movement of the adjusting ring directly drives the limiting piece 101 fixed relative to the adjusting ring to move. By varying the different contact portions 104, different injection amounts are preset.

In another embodiment of the second embodiment, referring to fig. 6, a thread is provided in the adjusting ring, and the contact portion 104 is provided with a mating thread surface; the limiting piece 101 comprises a pressable part 103 with one end arranged outside the loop 105 loop fixing range, and the other end is connected with the contact part 104 through a lever structure; after the two parts are in threaded engagement, rotation of the adjustment ring is translated into axial movement of the stop 101.

After the different contact portions 104 are connected with the collar 105, they are rotated by a predetermined amount. The adjusting precision can be improved through a rotary adjusting mode, namely the screw ratio is preset, and meanwhile, the preset quantity is observed, so that the condition that one-time adjustment is excessive or adjustment to an ideal position is difficult to realize is avoided.

In the third embodiment, the pressing part 2 is replaced by an electrically controlled pushing member capable of presetting the process. The electrically controlled pusher may be an electric motor or a stepper motor, which allows for precise control of the pressure applying portion 2 by inputting a preset electronic signal. In this case, the user can input the required medicine proportion and injection amount through a control panel on the device or an intelligent device connected with the device, and the electric control pushing member can automatically adjust the position of the pressing part 2 according to the input information, so that accurate medicine proportion and injection amount control is realized.

Or the displacement detection part is an optical sensor, and the displacement display 5 further comprises a display panel in real-time communication with the displacement detection part, and the display panel displays the displacement. The optical sensor may detect the real-time position of the pressing part 2 and transmit data to the display panel. In this case, the user can know the position of the pressing portion 2 in real time by observing the displacement amount on the display panel, thereby precisely adjusting the medicine ratio and the injection amount. For example, when the user rotates the pressing portion 2, the optical sensor detects a change in the position of the pressing portion 2 in real time and displays it on the display panel, and the user can adjust it according to the displayed displacement amount.

Or the displacement amount is converted into a preset injection amount according to the diameter of the drug reservoir 6. In this case, the apparatus can calculate the amount of the drug actually injected from the diameter of the drug reservoir 6 and the displacement amount of the pressing portion 2. For example, if the diameter of the medicine reservoir 6 is 1 mm and the displacement amount of the pressing portion 2 is 2 mm, the amount of medicine actually injected is 3.14 cubic mm. In this way, the user can directly preset the required injection amount without concern for the displacement amount.

Or the displacement display 5 is replaced by graduation marks marked beside the limiting part 101. In such an embodiment, the graduation marks may be directly marked on the side of the stopper 101 or the pressing portion 2, and the user may know the real-time position of the pressing portion 2 by observing the marks on the graduation marks. For example, when the user rotates the adjustment pressing part 2, a mark change on the scale mark may be observed, thereby adjusting the medicine ratio and the injection amount according to the mark. The design is simple and practical, and is suitable for occasions with lower requirements on precision.

The above is only an example portion of the application and is not intended to limit the application in any way. Any simple modification, equivalent variation and modification of the above embodiments still fall within the scope of the protection of the technical solution of this application.

Claims

1. The utility model provides a medicament ration configuration device, includes the medicine reservoir who deposits the medicine, the medicine reservoir connects the internal restriction have the piston, with piston body coupling's plunger, the plunger is responsible for promoting the piston, extrudes the medicine from the reservoir, and the direction of promotion intercommunication has the syringe needle that is used for the injection, the syringe needle with medicine reservoir intercommunication area is equipped with dose regulator, the dose regulator other end is equipped with the trigger, the trigger is connected with driving piece, its characterized in that: the metering regulator is provided with a communication part corresponding to each medicine container, the communication part is communicated with a mixed medicine temporary storage cavity arranged in the metering regulator, and the communication part is of a pressed open structure;

2. The device for quantitatively dispensing pharmaceutical agent according to claim 1, wherein: the pressure applying part is connected with a displacement display, and the displacement display is provided with a displacement detecting part for monitoring the displacement of the pressure applying part and displays the displacement in the displacement display in real time;

3. The medicine quantitative configuration device according to claim 2, wherein: the fixed reference also comprises a limiting piece for limiting the axial movement of the pressing part, the fixed position of the limiting piece on the fixed reference is pre-regulated according to various doses before injection, and the pressing part stops pushing after axially moving to the limiting piece;

4. A medicament dosing device according to claim 3, wherein: the fixed reference is a shell of the injector, the pressing part comprises push rods fixedly connected with the plungers, the number of the push rods is matched with that of the plungers, the other ends of all the push rods are fixed with a pushed part, and the pushed part is provided with a toggle switch;

5. The device according to claim 4, wherein: the limiting part is replaced by an adjusting ring which is fixed outside the shell in a ring sleeve mode and can axially rotate, only one adjusting ring is arranged, the limiting part comprises a contact part which can be bounced, the contact part is relatively fixed with the adjusting ring after bounced, and the contact part is driven by the adjusting ring to axially move.

6. The device for quantitatively dispensing pharmaceutical agent according to claim 5, wherein: the limiting piece comprises a compressible part with one end arranged outside the fixing range of the ring sleeve, and the other end is connected with the contact part through a lever structure;

7. The device for quantitatively dispensing pharmaceutical agent according to claim 5, wherein: the adjusting ring is internally provided with threads, and the contact part is provided with a thread surface matched with the contact part;

8. A medicament dosing device according to claim 3, wherein: the pressing part is replaced by an electric control pushing piece capable of presetting a process.

9. The device according to any one of claims 1 to 6, wherein: the displacement detection part is an optical sensor, and the displacement display further comprises a display panel in real-time communication with the optical sensor, and the display panel displays displacement;

10. The device according to any one of claims 1 to 6, wherein: the displacement display is replaced by scale marks marked on the side of the limiting piece.