CN116726414A - Personal thyroid I-131 internal irradiation evaluator - Google Patents
Personal thyroid I-131 internal irradiation evaluator Download PDFInfo
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- CN116726414A CN116726414A CN202310768516.XA CN202310768516A CN116726414A CN 116726414 A CN116726414 A CN 116726414A CN 202310768516 A CN202310768516 A CN 202310768516A CN 116726414 A CN116726414 A CN 116726414A
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- thyroid
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- detection unit
- region
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- 210000001685 thyroid gland Anatomy 0.000 title claims abstract description 68
- 238000001514 detection method Methods 0.000 claims abstract description 34
- 230000000694 effects Effects 0.000 claims abstract description 11
- 238000012545 processing Methods 0.000 claims abstract description 9
- 239000000758 substrate Substances 0.000 claims abstract description 4
- 238000005259 measurement Methods 0.000 claims description 17
- 230000005855 radiation Effects 0.000 claims description 11
- 238000005286 illumination Methods 0.000 claims description 8
- 239000004065 semiconductor Substances 0.000 claims description 4
- 230000008054 signal transmission Effects 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000523 sample Substances 0.000 claims description 2
- 238000010586 diagram Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 5
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 206010020850 Hyperthyroidism Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 210000000185 follicular epithelial cell Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of Radiation (AREA)
Abstract
The invention discloses a wearable personal thyroid I-131 internal irradiation evaluator, which belongs to a small wearable detection device, and comprises: the device comprises a measuring module and a fixing device, wherein the measuring module consists of a substrate and a detection unit covering a thyroid region, and the detection unit further comprises one or more groups of scintillators and detectors which are arranged according to the region and cover the thyroid region, a signal processing circuit and a power supply unit; the whole equipment does not need a collimator, can continuously or real-time measure thyroid gland dosage while reducing the complexity of the equipment, can continuously record and store the activity or internal irradiation dosage value at each moment, and improves the accuracy of measured data.
Description
Technical Field
The invention relates to the technical field of human body internal irradiation detection, in particular to a personal thyroid I-131 internal irradiation evaluator.
Background
Currently, I-131 is often used clinically for treating patients with hyperthyroidism (e.g., graves hyperthyroidism). Before treatment, the uptake function of the thyroid gland is required to be detected through an iodine uptake experiment, the activity or the dosage of the thyroid gland of a patient is required to be monitored in the detection process, after the patient orally takes trace iodine-131 on an empty stomach, the iodine-131 enters the thyroid gland along with blood through stomach and intestine absorption and is rapidly taken by thyroid gland follicular epithelial cells, the intake quantity and the speed are closely related to the function of the thyroid gland, and the thyroid gland iodine uptake rate at different time points can be calculated by measuring the radiation quantity of the thyroid gland part absorbing the iodine-131 at different time points, so that the capability of the thyroid gland to absorb the iodine-131 and synthesize and secrete thyroid hormone is reflected; in the treatment process, the activity or the dosage of thyroid gland of the patient is also required to be monitored, so that the safe treatment dosage is ensured, and the damage to the patient caused by the radiation generated by excessive dosage is avoided, thereby achieving the ideal treatment effect.
In the prior art, common devices for detecting I-131 include: thyroid function, gamma camera, SPECT, etc., which can measure the distribution and metabolism of the thyroid I-131 in a patient. However, most of the above devices are stationary devices, which typically weigh hundreds of kilograms or even hundreds of kilograms, and continuous monitoring of the I-131 distribution in the patient's body is not possible. In recent years, portable emergency thyroid radiation monitors have been reported to control the total weight of the monitor to not more than 30Kg; there are also research and development messages on hand-held gamma cameras claiming to weigh also approximately 800 grams; he Lihua et al describe a thyroid dosimeter consisting of a NaI (Tl) crystal probe and an intelligent data recording system providing intake and to-be-integrated effective dose equivalents, measuring in the range of 10 to 2X 10 6 Bq, the measuring instrument is also provided with a peak stabilizing circuit, so that the stability of the instrument is ensured; however, due to the detection principle and the minimum weight of the device, the wearable technical requirements of the device still cannot be realized.
In general, the current activity or dosage devices for various thyroid glands need to be equipped with collimators, are very bulky and heavy, and in particular cannot give an I-131 internal radiation dose, without a wearable personal thyroid gland I-131 internal radiation evaluator.
Disclosure of Invention
The invention aims to provide a wearable personal intra-thyroid I-131 irradiation evaluator, which realizes continuous monitoring of intra-thyroid I-131 irradiation dose distribution of a patient.
To achieve the above object, the present invention provides a wearable personal thyroid I-131 internal irradiation evaluator comprising: a measurement module and a fixture.
The fixation device secures the measurement module in a position above the thyroid region of the patient.
Optionally, the fixing device realizes the relative fixation of the measuring module and the thyroid region position of the patient through elastic fabric; the fixing device is provided with a pocket, and the measuring module is arranged in the pocket.
The measurement module enables measurement of the radiation dose of the thyroid region I-131 of the patient.
Optionally, the measurement module is composed of a substrate and a detection unit covering the thyroid region.
The detection unit includes: one or more sets of area-wise scintillators and detectors covering the thyroid region should be used to wrap the scintillator with a surface that diffusely scatters (strongly reflecting, non-absorbing) the fluorescence.
The detection unit further includes: a signal processing circuit and a power supply unit; the signal processing circuit is composed of a signal amplifying circuit, a signal collecting circuit, a signal storage circuit and a signal transmission circuit; the power supply unit consists of a battery and a power management unit and supplies power to the detection unit.
Optionally, the scintillator is a non-columnar plastic scintillator or a liquid scintillator, and the detector is a photoelectric detector.
Optionally, the detection unit includes: one or more sets of columnar scintillators and photodetectors arranged in regions covering the thyroid region.
Optionally, the detection unit includes: one or more groups of GM tubes covering the thyroid region.
Optionally, the detection unit includes: one or more sets of semiconductor detectors covering the thyroid region.
The signal transmission circuit transmits the detection data to a nurse/doctor workstation in real time through Bluetooth/Wifi.
Compared with the prior art, the invention has the following advantages and beneficial effects:
1. the wearable personal thyroid gland I-131 internal irradiation evaluator provided by the invention belongs to a small wearable detection device, the whole equipment does not need a collimator, the thyroid gland dose can be continuously or real-time measured while the complexity of the equipment is reduced, the I-131 internal irradiation dose can be estimated, the activity or the internal irradiation dose value at each moment can be continuously recorded and stored, the accuracy of the internal irradiation dose is improved, the detection data can be shared in real time by the equipment through wireless transmission, and the medical data information synchronization between doctors and patients is realized.
2. The invention has the additional beneficial effects that: the personal thyroid I-131 internal irradiation evaluator can also be used as an A-dynamometer, and can obtain more thyroid function information compared with the traditional A-dynamometer, so that more information is provided for thyroid diagnosis, and the accuracy, precision and confidence of diagnosis are improved; the device can also be used as emergency equipment for reactor accidents, and is used for detecting the I-131 internal irradiation hazard suffered by treatment personnel.
Drawings
FIG. 1 is a schematic diagram showing the composition of an illumination evaluator in a personal thyroid I-131 according to an embodiment of the present invention.
Fig. 2 is a schematic diagram (front view) of a measurement module according to an embodiment of the invention.
Fig. 3 is a schematic diagram (side view) of a detecting unit according to an embodiment of the present invention.
Fig. 4 is a detailed block diagram of a detecting unit according to an embodiment of the present invention.
Fig. 5 is a schematic diagram illustrating a part of a detecting unit according to an embodiment of the present invention.
Fig. 6 is a schematic diagram showing a part of a detecting unit according to another embodiment of the present invention.
In the figure: the device comprises a measuring module-1, a fixing device-2, a detecting unit-12, a scintillator-121, a detector-122, a signal processing circuit-123, a power supply unit-124, a GM tube-125 and a semiconductor detector-126.
Detailed Description
The technical scheme of the present invention is described in further detail below with reference to the accompanying drawings, but the scope of the present invention is not limited to the following.
For the purpose of making the technical solution and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the invention, i.e., the embodiments described are merely some, but not all, of the embodiments of the invention.
Example 1:
as shown in fig. 1, which is a schematic diagram of the composition of a personal thyroid I-131 internal irradiation evaluator according to the present invention, the internal irradiation evaluator comprises: a measurement module 1 and a fixation device 2, the fixation device 2 fixing the measurement module 1 in a position above the thyroid region of the patient.
The fixing device realizes the relative fixation of the measuring module 1 and the thyroid region position of the patient through elastic fabrics; the fixing device can be provided with a pocket, the measuring module can be arranged in the pocket, and the measuring module 1 can be fixed in a back sticking buckle mode.
It should be noted that the illustration and description of fig. 1 is only an example of the fixing means, and the purpose of the fixing device 2 is to fix the measuring module 1 in a position corresponding to the thyroid, and other fixing means are also an embodiment of the fixing device 2, such as fixing to the collar or fixing to the neck or the chest by a bracket.
It should be noted that some components of the measurement module 1 may be disposed in the fixing device 2 as needed to improve wearing comfort.
The measurement module 1 enables measurement of the radiation dose or count of the thyroid region I-131 of the patient.
It should be noted that the measurement module 1 directly detects the gamma dose or count of the amount I-131. The scale factors can be obtained through a scale experiment, and the activity value of the thyroid gland and the internal irradiation dose mainly based on beta irradiation are calculated.
The main calculation formula is as follows:
1) Activity of iodine in thyroid A (t)
A(t)＝Cr(t)хf
Wherein: cr (t) is the counting rate of the moment t; f is a scale factor, and the conversion of the measurement count rate and the thyroid actual activity can be realized by using the scale factor.
2) Equivalent of internal irradiation dose
I-131 starts to enter thyroid gland at time t0, and the internal irradiation dose equivalent H received by thyroid gland is cut off from time t T (t)
Wherein: c is the internal irradiation dose per activity on thyroid. H T (t), units: hivolte (Sv).
3) Effective dose equivalent of internal irradiation
H E (t)＝H T (t)*W T
Wherein: w (W) T Is the tissue weight factor of the thyroid. H E (t), units: hivolte (Sv).
As shown in fig. 2, a schematic diagram of a measurement module according to an embodiment of the present invention is shown, and the measurement module is composed of a substrate 11 and a detection unit 12 covering a thyroid region.
As shown in fig. 3, which is a schematic diagram of the composition of a detection unit according to an embodiment of the present invention, the detection unit 12 further includes: one or more sets of area-wise scintillators 121 and detectors 122 covering the thyroid area.
The scintillator 121 is a non-columnar plastic scintillator or a liquid scintillator, and the scintillator 121 should be wrapped with a material that diffusely scatters (strongly reflecting, non-absorbing) fluorescence; the detector 122 is a photodetector, preferably of the small, lightweight type, such as a multi-pixel photon counter (MPPC), also known as a silicon photomultiplier (SiPM).
As shown in fig. 4, fig. 4 shows a combination of 4 sets of scintillators 121 and detectors 122. The detection unit 12 further includes: a signal processing circuit 123 and a power supply unit 124; the signal processing circuit 123 is constituted by a signal amplifying circuit, a signal collecting circuit, a signal storing circuit, and a signal transmitting circuit; the power supply unit 124 is composed of a battery and a power management unit, and supplies power to the detection unit.
The signal transmission circuit transmits the detection data to the nurse/doctor workstation in real time. The workstation may be a computer device that specifically performs data processing operations, and may communicate wirelessly with the detection unit 12 using Wi-Fi, bluetooth, or other communication protocols.
It should be noted that, in the above embodiment, only a combination of the detecting units 12 is shown, and the non-columnar scintillator 121 and the detector 122 thereof may be replaced by other components having the same functions. Such as: the non-columnar scintillators 121 and detectors 122 are replaced with one or more sets of columnar scintillators and photodetectors arranged in regions covering the thyroid region.
In addition, fig. 5 and 6 show a partial composition schematic of one kind of the detection unit and a partial composition schematic of another kind of the detection unit, respectively. The non-columnar scintillator 121 and detector 122 are replaced with one or more GM tubes 125 covering the thyroid region and one or more semiconductor detectors 126 covering the thyroid region, respectively, for detection purposes as well.
It should be noted that, according to clinical needs, other parts of the body may also need to be monitored; the shape is properly adjusted, and the internal irradiation dose of the urinary system/bladder, digestive system/stomach, specific metastasis, and the like can be monitored.
The foregoing description of the embodiments has been provided for the purpose of illustrating the general principles of the invention, and is not meant to limit the scope of the invention, but to limit the invention to the particular embodiments, and any modifications, equivalents, improvements, etc. that fall within the spirit and principles of the invention are intended to be included within the scope of the invention.
Claims (9)
1. A personal thyroid I-131 endo-illumination evaluator, the endo-illumination evaluator comprising: a measuring module (1) and a fixing device (2);
the fixing device (2) is used for fixing the measuring module (1) at a position above a thyroid region of a patient;
the measuring module (1) is used for measuring the I-131 gamma radiation dose of the thyroid region of the patient and estimating the internal radiation dose caused by the I-131 beta internal radiation.
2. The I-131 internal irradiation evaluator according to claim 1, wherein the measurement module (1) consists of a substrate (11) and a detection unit (12) covering a thyroid region.
3. The I-131 internal irradiation evaluator according to any one of claims 1-2, said fixation means (2) effecting a relative fixation of the position of the measurement module (1) and the thyroid region of the patient by means of an elastic fabric; the fixing device (2) is provided with a pocket in which the measuring module (1) is mounted.
4. The I-131 internal illumination evaluator as set forth in claim 2, wherein the detection unit (12) includes: one or more sets of area-wise scintillators (121) and detectors (122) covering the thyroid area;
the scintillator (121) is a non-columnar plastic scintillator or a liquid scintillator;
the detector (122) is a photodetector.
5. The I-131 internal illumination evaluator as set forth in claim 2, wherein the detection unit (12) includes: one or more sets of columnar scintillators and photodetectors arranged in regions covering the thyroid region.
6. The I-131 internal illumination evaluator as set forth in claim 2, wherein the detection unit (12) includes: one or more groups of GM tubes (125) covering the thyroid region.
7. The I-131 internal illumination evaluator as set forth in claim 2, wherein the detection unit (12) includes: one or more sets of semiconductor detectors (126) covering the thyroid region.
8. The I-131 internal illumination evaluator as set forth in any one of claims 4-7, wherein the detection unit (12) further includes: a signal processing circuit (123) and a power supply unit (124); the signal processing circuit (123) is composed of a signal amplifying circuit, a signal collecting circuit, a signal storing circuit and a signal transmitting circuit; the power supply unit (124) consists of a battery and a power supply management unit and supplies power to the detection unit (12);
the detection unit (12) is used for measuring the dosage of the I-131 gamma radiation of the thyroid region of the patient and estimating the internal irradiation dosage caused by the I-131 beta internal irradiation, and the internal irradiation dosage is calculated as follows:
i-131 starts to enter thyroid gland at time t0, and the internal irradiation dose equivalent H received by thyroid gland is cut off from time t T (t)，
Wherein: c is the internal irradiation dose of the unit activity on thyroid, H T Units of (t): hivolte (Sv);
internal irradiation effective dose equivalent H E (t)＝H T (t)*W T Wherein: w (W) T Is the tissue weight factor of thyroid, H E Units of (t): hivolte (Sv).
9. The I-131 in-radiation evaluator of claim 8, wherein said signal transmission circuit transmits the probe data to the nurse/doctor station in real time via bluetooth/Wifi.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310768516.XA CN116726414A (en) | 2023-06-27 | 2023-06-27 | Personal thyroid I-131 internal irradiation evaluator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310768516.XA CN116726414A (en) | 2023-06-27 | 2023-06-27 | Personal thyroid I-131 internal irradiation evaluator |
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| CN116726414A true CN116726414A (en) | 2023-09-12 |
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| CN202310768516.XA Pending CN116726414A (en) | 2023-06-27 | 2023-06-27 | Personal thyroid I-131 internal irradiation evaluator |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117122345A (en) * | 2023-10-26 | 2023-11-28 | 佛山市龙生光启科技有限公司 | Thyroid function evaluation intelligent detection system based on gamma rays |
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2023
- 2023-06-27 CN CN202310768516.XA patent/CN116726414A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117122345A (en) * | 2023-10-26 | 2023-11-28 | 佛山市龙生光启科技有限公司 | Thyroid function evaluation intelligent detection system based on gamma rays |
| CN117122345B (en) * | 2023-10-26 | 2024-03-19 | 衡阳市中心医院 | Thyroid function evaluation intelligent detection system based on gamma rays |
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