CN116726042A - Formula food for preparing intestinal tract by digestive endoscopy and preparation method thereof - Google Patents
Formula food for preparing intestinal tract by digestive endoscopy and preparation method thereof Download PDFInfo
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- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 230000001079 digestive effect Effects 0.000 title claims abstract description 14
- 238000001839 endoscopy Methods 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 43
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229920001202 Inulin Polymers 0.000 claims abstract description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 14
- 229920001100 Polydextrose Polymers 0.000 claims abstract description 14
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 14
- 229940107187 fructooligosaccharide Drugs 0.000 claims abstract description 14
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 14
- 229940029339 inulin Drugs 0.000 claims abstract description 14
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 14
- 239000008101 lactose Substances 0.000 claims abstract description 14
- 229940035035 polydextrose Drugs 0.000 claims abstract description 14
- 235000013856 polydextrose Nutrition 0.000 claims abstract description 14
- 239000001259 polydextrose Substances 0.000 claims abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 239000004376 Sucralose Substances 0.000 claims abstract description 9
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 9
- 235000019408 sucralose Nutrition 0.000 claims abstract description 9
- 238000004806 packaging method and process Methods 0.000 claims abstract description 7
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 7
- 230000000968 intestinal effect Effects 0.000 claims abstract description 6
- 239000008236 heating water Substances 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 2
- 239000012669 liquid formulation Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 235000005911 diet Nutrition 0.000 abstract description 2
- 230000037213 diet Effects 0.000 abstract description 2
- 230000036186 satiety Effects 0.000 abstract description 2
- 235000019627 satiety Nutrition 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000008984 colonic lesion Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/25—Synthetic polymers, e.g. vinylic or acrylic polymers
- A23L33/26—Polyol polyesters, e.g. sucrose polyesters; Synthetic sugar polymers, e.g. polydextrose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a formula food for preparing intestinal tracts in a digestive endoscopy and a preparation method thereof, wherein the formula food comprises polydextrose, fructo-oligosaccharide, isomerized lactose solution, isomaltooligosaccharide, inulin and edible salt; the preparation method of the formula food comprises the following steps: uniformly mixing polydextrose, fructo-oligosaccharide, isomerized lactose solution, isomaltooligosaccharide, inulin and edible salt to obtain a mixture A; heating water to 75-85 ℃, slowly adding the mixture A, and uniformly mixing to obtain a mixture B; slowly adding edible essence and sucralose into the mixture B, and uniformly mixing to obtain a mixture C; packaging the mixture C in a container, and performing high-pressure damp-heat sterilization to obtain the formula food. The formula food disclosed by the invention is beneficial to normalizing the diet of a patient in intestinal tract preparation within 24 hours before intestinal tract preparation, provides satiety, reduces generation of intestinal residues, promotes intestinal tract cleaning, shortens the intestinal tract preparation time, and has excellent intestinal tract cleaning effect and patient compliance.
Description
Technical Field
The invention relates to the technical field of special medical formula food, in particular to a formula food for preparing intestinal tracts for digestive endoscopy and a preparation method thereof.
Background
Enteroscopy is an examination method in which a enteroscopy lumen is inserted into a ileocecal region through the anus, and a colonic lesion is observed from the mucosal side. Enteroscopy can meet the examination needs of almost all colon regions. The intestinal tract is cleaned before examination, the intestinal tract is prepared according to the doctor's advice, the intestinal tract cleaning person takes the oral medicine, the patient takes more water after taking the medicine, and finally the discharged stool is clear water or light yellow, and no fecal residue exists, so that the intestinal tract cleaning effect is optimal.
The existing medicines commonly used for intestinal tract preparation include polyethylene glycol (PEG), magnesium sulfate, sodium sulfate and the like, but most of the medicines have adverse reactions such as poor taste, large dosage, easy occurrence of nausea, vomiting, abdominal distension and the like, and have the problem of poor bowel clearing effect, and are easy to reduce compliance of patients and increase medical burden of enteroscopy.
In order to solve the defects of the traditional intestinal tract preparation method, the field needs to develop a medicament with excellent intestinal tract cleaning effect and high patient compliance.
Disclosure of Invention
Therefore, the invention aims to solve the technical problems of unsatisfactory effect, long preparation time, easy generation of adverse reaction and the like of the intestinal tract cleaning method in the prior art, thereby providing the formula food for preparing the intestinal tract for the digestive endoscopy and the preparation method thereof.
The invention provides a formula food for preparing intestinal tracts in a digestive endoscopy, which is characterized by comprising the following components in parts by weight:
3-8 parts of polydextrose;
2-6 parts of fructo-oligosaccharide;
2-6 parts of isomerized lactose liquid;
0.5-5 parts of isomaltooligosaccharide;
0.5-5 parts of inulin;
0.1-1 part of edible salt.
Preferably, the formula further comprises:
72-88 parts of water;
0.02-0.82 parts of flavoring agent.
Preferably, the flavoring agent comprises flavoring essence and sucralose.
Preferably, the formulation is in the form of a liquid formulation.
The invention also provides a preparation method of the formula food for preparing the digestive endoscopy intestinal tract, which comprises the following steps:
1) Uniformly mixing polydextrose, fructo-oligosaccharide, isomerized lactose solution, isomaltooligosaccharide, inulin and edible salt to obtain a mixture A;
2) Heating water to 75-85 ℃, slowly adding the mixture A, and uniformly mixing to obtain a mixture B;
3) Slowly adding edible essence and sucralose into the mixture B, and uniformly mixing to obtain a mixture C;
4) Packaging the mixture C in a container, and performing high-pressure damp-heat sterilization to obtain the formula food.
1. The formula food for digestive endoscopy intestinal tract preparation is beneficial to normalizing diet within 24 hours before intestinal tract preparation of an intestinal tract preparation patient, provides satiety, reduces generation of intestinal tract residues, promotes intestinal tract cleaning, shortens intestinal tract preparation time, and has excellent intestinal tract cleaning effect and patient compliance.
2. The preparation method of the formula food for preparing the intestinal tract for the digestive endoscopy provided by the invention is prepared by a simple process, can be applied to clinical use, and has strong practicability.
Detailed Description
The following examples are provided for a better understanding of the present invention and are not limited to the preferred embodiments described herein, but are not intended to limit the scope of the invention, any product which is the same or similar to the present invention, whether in light of the present teachings or in combination with other prior art features, falls within the scope of the present invention.
The specific experimental procedures or conditions are not noted in the examples and may be followed by the operations or conditions of conventional experimental procedures described in the literature in this field. The reagents or apparatus used were conventional reagent products commercially available without the manufacturer's knowledge.
Example 1
And step 1, respectively weighing 4% of polydextrose, 3% of fructo-oligosaccharide, 3.5% of isomerized lactose solution, 2.5% of isomaltooligosaccharide, 2% of inulin, 0.4% of edible salt and 84.6% of water according to the mass percentage, wherein the sum of the mass percentages of the components is 100%, and further weighing 0.1% of edible essence and 0.04% of sucralose, and uniformly mixing the weighed polydextrose, fructooligosaccharide, isomerized lactose solution, isomaltooligosaccharide, inulin and edible salt to obtain a mixture A.
And 2, heating the water weighed in the step 1 to 75-85 ℃.
And 3, slowly adding the mixture A obtained in the step 1 into the hot water obtained in the step 2, and uniformly mixing to obtain a mixture B.
Step 4, slowly adding the edible essence weighed in the step 1 and the sucralose into the mixture B obtained in the step 3, and uniformly mixing to obtain a mixture C;
and 5, packaging the mixture C obtained in the step 4 in a container for high-pressure damp-heat sterilization. The product of the invention can be obtained.
Example 2
And 1, respectively weighing 6.5% of polydextrose, 4.5% of fructo-oligosaccharide, 4% of isomerized lactose solution, 3% of isomaltooligosaccharide, 1% of inulin, 0.8% of edible salt and 80.8% of water according to the mass percentage, wherein the sum of the mass percentages of the components is 100%, and the other components are 0.4% of edible essence and 0.02% of sucralose, and uniformly mixing the weighed polydextrose, fructooligosaccharide, the isomerized lactose solution, the isomaltooligosaccharide, the inulin and the edible salt to obtain a mixture A.
And 2, heating the water weighed in the step 1 to 75-85 ℃.
And 3, slowly adding the mixture A obtained in the step 1 into the hot water obtained in the step 2, and uniformly mixing to obtain a mixture B.
Step 4, slowly adding the edible essence weighed in the step 1 and the sucralose into the mixture B obtained in the step 3, and uniformly mixing to obtain a mixture C;
and 5, packaging the mixture C obtained in the step 4 in a container for high-pressure damp-heat sterilization. The product of the invention can be obtained.
Example 3
And 1, respectively weighing 3.5% of polydextrose, 2.8% of fructo-oligosaccharide, 2.8% of isomerized lactose solution, 1.4% of isomaltooligosaccharide, 3.8% of inulin, 0.2% of edible salt and 85.5% of water according to the mass percentage, and uniformly mixing the weighed polydextrose, fructo-oligosaccharide, the isomerized lactose solution, the isomaltooligosaccharide, the inulin and the edible salt to obtain a mixture A, wherein the sum of the mass percentages of the components is 100%.
And 2, heating the water weighed in the step 1 to 75-85 ℃.
And 3, slowly adding the mixture A obtained in the step 1 into the hot water obtained in the step 2, and uniformly mixing to obtain a mixture B.
Step 4, slowly adding the edible essence weighed in the step 1 into the mixture B obtained in the step 3, and uniformly mixing to obtain a mixture C;
and 5, packaging the mixture C obtained in the step 4 in a container for high-pressure damp-heat sterilization. The product of the invention can be obtained.
Example 4
And step 1, weighing 5.5% of polydextrose, 4% of fructo-oligosaccharide, 4% of isomerized lactose solution, 4.5% of isomaltooligosaccharide, 3% of inulin, 0.5% of edible salt and 78.5% of water according to the mass percentage, and mixing the weighed polydextrose, fructo-oligosaccharide, the isomerized lactose solution, the isomaltooligosaccharide, the inulin and the edible salt uniformly to obtain a mixture A.
And 2, heating the water weighed in the step 1 to 75-85 ℃.
And 3, slowly adding the mixture A obtained in the step 1 into the hot water obtained in the step 2, and uniformly mixing to obtain a mixture B.
Step 4, slowly adding the edible essence weighed in the step 1 into the mixture B obtained in the step 3, and uniformly mixing to obtain a mixture C;
and 5, packaging the mixture C obtained in the step 4 in a container for high-pressure damp-heat sterilization. The product of the invention can be obtained.
The 40 mice were divided into four groups of 10 mice each, each male and female half. After 12 hours of fasting, the control group was perfused with 0.4mL of 5% activated carbon physiological saline, and the experimental group was perfused with 0.2, 0.4, and 0.6mL of 5% activated carbon test solution, respectively (the test solution is the formula obtained in example 4). After 3 hours, cervical dislocation is killed, abdominal cavity is dissected, the alimentary canal is taken out, the distance from the pylorus to the front of the active carbon and the total length of the intestinal tract are measured, and the propulsion rate (the length from the pylorus to the front of the active carbon/the total length of the small intestine) is calculated. The data obtained are shown in table 1.
TABLE 1 Propulsion rates for different groups
As can be seen from Table 1, compared with the normal saline group, the administration amount of the test sample is 0.6mL, the generation of intestinal residues is less, and the degree of intestinal cleaning is highest, which indicates that the higher the administration amount of the formula food obtained by the invention is, the higher the propulsion rate is, the formula food obtained by the invention can effectively reduce the generation of intestinal residues, promote the intestinal cleaning and shorten the preparation time of intestinal tracts.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the invention.
Claims (5)
1. A formula for digestive endoscopy intestinal tract preparation, characterized by comprising the following components in parts by weight:
3-8 parts of polydextrose;
2-6 parts of fructo-oligosaccharide;
2-6 parts of isomerized lactose liquid;
0.5-5 parts of isomaltooligosaccharide;
0.5-5 parts of inulin;
0.1-1 part of edible salt.
2. The formula for digestive endoscopy intestinal tract preparation of claim 1, wherein the formula further comprises:
72-88 parts of water;
0.02-0.82 parts of flavoring agent.
3. The formula for digestive endoscopy intestinal tract preparation of claim 2, wherein the flavoring agent comprises edible essence and sucralose.
4. A formula for digestive endoscopy intestinal tract preparation according to any one of claims 1-3, wherein the formula dosage form is a liquid formulation.
5. A method of preparing a formula for digestive endoscopy intestinal preparation as claimed in claim 4, comprising the steps of:
1) Uniformly mixing polydextrose, fructo-oligosaccharide, isomerized lactose solution, isomaltooligosaccharide, inulin and edible salt to obtain a mixture A;
2) Heating water to 75-85 ℃, slowly adding the mixture A, and uniformly mixing to obtain a mixture B;
3) Slowly adding edible essence and sucralose into the mixture B, and uniformly mixing to obtain a mixture C;
4) Packaging the mixture C in a container, and performing high-pressure damp-heat sterilization to obtain the formula food.
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| CN202310788363.5A CN116726042A (en) | 2023-06-30 | 2023-06-30 | Formula food for preparing intestinal tract by digestive endoscopy and preparation method thereof |
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| CN202310788363.5A CN116726042A (en) | 2023-06-30 | 2023-06-30 | Formula food for preparing intestinal tract by digestive endoscopy and preparation method thereof |
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