CN116649496A - Rosmarinic acid premix for relieving particulate matter-induced pulmonary inflammation of broiler chickens - Google Patents
Rosmarinic acid premix for relieving particulate matter-induced pulmonary inflammation of broiler chickens Download PDFInfo
- Publication number
- CN116649496A CN116649496A CN202310698142.9A CN202310698142A CN116649496A CN 116649496 A CN116649496 A CN 116649496A CN 202310698142 A CN202310698142 A CN 202310698142A CN 116649496 A CN116649496 A CN 116649496A
- Authority
- CN
- China
- Prior art keywords
- parts
- sulfate monohydrate
- rosmarinic acid
- premix
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 title claims abstract description 80
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 54
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 title claims abstract description 39
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 title claims abstract description 39
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 206010035664 Pneumonia Diseases 0.000 title claims abstract description 28
- 239000013618 particulate matter Substances 0.000 title description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims abstract description 45
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- 239000004575 stone Substances 0.000 claims abstract description 22
- -1 compound vitamin Chemical class 0.000 claims abstract description 16
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 claims abstract description 15
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims abstract description 15
- XBDUTCVQJHJTQZ-UHFFFAOYSA-L iron(2+) sulfate monohydrate Chemical compound O.[Fe+2].[O-]S([O-])(=O)=O XBDUTCVQJHJTQZ-UHFFFAOYSA-L 0.000 claims abstract description 15
- ISPYRSDWRDQNSW-UHFFFAOYSA-L manganese(II) sulfate monohydrate Chemical compound O.[Mn+2].[O-]S([O-])(=O)=O ISPYRSDWRDQNSW-UHFFFAOYSA-L 0.000 claims abstract description 15
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Classifications
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Abstract
The invention discloses a rosmarinic acid premix for relieving lung inflammation of broiler chickens induced by particles, which relates to the technical field of cultivation and comprises the following raw materials in parts by weight: 600-620 parts of corn, 300-310 parts of bean pulp, 40-50 parts of soybean oil, 10-20 parts of stone powder, 10-20 parts of calcium hydride, 1-5 parts of salt, 1-2 parts of lysine, 1-2 parts of methionine, 1-3 parts of 50% choline, 2-4 parts of compound premix and 0.1-2.0 parts of compound vitamin; the compound premix comprises the following components in parts by weight: 30-50g of copper sulfate pentahydrate, 120-150g of ferrous sulfate monohydrate, 150-170g of manganese sulfate monohydrate, 100-120g of zinc sulfate monohydrate, 30-50g of 1% sodium selenite, 10-20g of 1% potassium iodide, 380-400g of medical stone and 100-120g of 10% rosmarinic acid. The feed disclosed by the invention has the advantages of scientific and reasonable formula, capability of obviously reducing lung inflammation, inhibiting lung TLR4 signal paths, remodelling intestinal flora, obviously improving the immunity and production performance of broiler chickens, small side effect of feed proportioning, no residue, no drug resistance, no environmental pollution, resistance increase and further improvement of the economic benefit of broiler chickens cultivation.
Description
Technical Field
The invention belongs to the technical field of cultivation, and particularly relates to a rosmarinic acid premix for relieving lung inflammation of broiler chickens induced by particles.
Background
With the development of the intensive closed livestock and poultry breeding mode, a large amount of Particulate Matters (PM) are generated in the high-density livestock and poultry breeding process, which also becomes PM in the environment 2.5 PM can adsorb toxins and microorganisms and can directly reach the lung, and high concentration of PM can directly cause lung injury, thereby inducing respiratory diseases, seriously affecting animal production and reducing economic benefit.
However, most of chicken houses in modern feeding farms are closed, especially broiler chicken houses are mostly in environments with exposed high-concentration particles, so that air quality is poor, viruses and bacteria are more, and pneumonia is easily caused; in addition, the unbalanced proportion of the broiler feed directly causes the immunity of broiler chickens to be reduced and the disease resistance to be poor if the content of nutrient elements and trace elements in daily ration is too low, thereby causing pneumonia.
The existing treatment aiming at the broiler pneumonia mostly adopts western medicines, antibiotics or traditional Chinese medicines for improving the immunity of organisms and improving the cure rate, but has a certain prevention and treatment effect in the early stage, the treatment effect is gradually reduced along with the massive use of medicines, the medicine resistance and the medicine residue are easy to be caused, the problem of the antibiotic resistance is easy to be generated after long-term use, the food safety is further influenced, and the life and the health of people are seriously threatened when people eat the medicines.
Disclosure of Invention
Aiming at the defects and problems that the existing treatment method for the broiler pneumonia gradually reduces the treatment effect, is easy to cause drug resistance and drug residue, is easy to generate antibiotic resistance after long-term use, and further influences food safety, the invention provides the rosmarinic acid premix for relieving the broiler lung inflammation induced by particles.
The invention solves the technical problems by adopting the scheme that: the rosmarinic acid premix for relieving the lung inflammation of the broiler chickens induced by the particles comprises the following raw materials in parts by weight: 600-620 parts of corn, 300-310 parts of bean pulp, 40-50 parts of soybean oil, 10-20 parts of stone powder, 10-20 parts of calcium hydride, 1-5 parts of salt, 1-2 parts of lysine, 1-2 parts of methionine, 1-3 parts of 50% choline, 2-4 parts of compound premix and 0.1-2.0 parts of compound vitamin;
the compound premix comprises the following components in parts by weight: 30-50g of copper sulfate pentahydrate, 120-150g of ferrous sulfate monohydrate, 150-170g of manganese sulfate monohydrate, 100-120g of zinc sulfate monohydrate, 30-50g of 1% sodium selenite, 10-20g of 1% potassium iodide, 380-400g of medical stone and 100-120g of 10% rosmarinic acid.
Further, after the compound vitamin is added, the compound vitamin meets the requirements of 12000-15000IU, 1000-3000IU VD, 20-22mg VE, 3 2-3.2mg VK, 1 1-3mg VB2 2-5mg VB6 2-4mg, 0.02-0.03mg VB, 0.03-0.04mg biotin, 1-3mg folic acid, 10-12mg D-pantothenic acid and 50-60mg nicotinic acid in per kilogram of basic ration.
Further, the compound premix comprises the following components in parts by weight: 30g of copper sulfate pentahydrate, 140g of ferrous sulfate monohydrate, 160g of manganese sulfate monohydrate, 120g of zinc sulfate monohydrate, 40g of 1% sodium selenite, 20g of 1% potassium iodide, 390g of medical stone and 100g of 10% rosmarinic acid.
Further, the compound premix comprises the following components in parts by weight: 40g of copper sulfate pentahydrate, 120g of ferrous sulfate monohydrate, 170g of manganese sulfate monohydrate, 120g of zinc sulfate monohydrate, 30g of 1% sodium selenite, 10g of 1% potassium iodide, 380g of medical stone and 120g of 10% rosmarinic acid.
Further, the compound premix comprises the following components in parts by weight: 50g of copper sulfate pentahydrate, 130g of ferrous sulfate monohydrate, 150g of manganese sulfate monohydrate, 110g of zinc sulfate monohydrate, 45g of 1% sodium selenite, 15g of 1% potassium iodide, 400g of medical stone and 100g of 10% rosmarinic acid.
Further, the compound premix comprises the following components in parts by weight: 35g of copper sulfate pentahydrate, 150g of ferrous sulfate monohydrate, 165g of manganese sulfate monohydrate, 100g of zinc sulfate monohydrate, 32g of 1% sodium selenite, 18g of 1% potassium iodide, 390g of medical stone and 110g of 10% rosmarinic acid.
Compared with the prior art, the invention has the beneficial effects that:
the rosmarinic acid premix for relieving the lung inflammation of the broiler chickens induced by the particulate matters provided by the invention is characterized in that the compound premix prepared by rosmarinic acid and other substances is added into daily ration feed of the broiler chickens, the formula is scientific and reasonable, and the compound premix is used for relieving the lung inflammation of the broiler chickens and promoting the recovery of the lung function; experiments prove that the method can effectively reduce the content of inflammatory factors in chicken blood and lung tissues, thereby obviously improving the immunity and the production performance of broiler chickens, and the premix has small proportioning side effect, no residue, no drug resistance, no environmental pollution and resistance increase; meanwhile, the feed additive also has the effects of rebalancing intestinal flora, improving lung inflammation and injury, regulating TLR4 signal paths and the like, so that the economic benefit of broiler breeding is further improved, and the feed additive has a wide application prospect.
Drawings
FIG. 1 is a graph showing the comparison of the experimental results of inflammatory factors in blood according to the present invention;
FIG. 2 is a graph showing comparison of inflammatory factor experimental results in lung tissue according to the present invention;
FIG. 3 is a graph showing comparison of detection results of TLR4 signal paths in lung tissues of broilers according to the present invention;
FIG. 4 is a bar graph of the cecal content flora structure according to the present invention;
fig. 5 is a graph comparing the detection results of cecum flora of broilers of the present invention.
Description of the embodiments
The invention will be further described with reference to the drawings and examples.
Referring to fig. 1-2, the invention provides a technical scheme of rosmarinic acid premix for relieving lung inflammation of broiler chickens induced by particulates, which is suitable for feeding broiler chickens of 22-42 days, and adopts a brand new compound premix containing rosmarinic acid for improving the problems of lung injury of broiler chickens induced by LPS and the like so as to exert better anti-inflammatory effect.
Examples
The embodiment provides a rosmarinic acid premix for relieving lung inflammation of broiler chickens induced by particles, which comprises the following raw materials in parts by weight in every 1000kg of daily ration: 612.8kg of corn, 305kg of bean pulp, 45kg of soybean oil, 13kg of stone powder, 14kg of calcium hydroxide, 3kg of salt, 1.4kg of lysine, 1.3kg of methionine, 2kg of 50% choline, 2.2kg of compound premix and 0.3kg of compound vitamin;
wherein each 1kg of the compound premix comprises the following components in parts by weight: 30g of copper sulfate pentahydrate, 140g of ferrous sulfate monohydrate, 160g of manganese sulfate monohydrate, 120g of zinc sulfate monohydrate, 40g of 1% sodium selenite (containing 0.45% of selenium), 20g of 1% potassium iodide (containing 0.76% of iodine), 390g of medical stone and 100g of 10% rosmarinic acid;
the raw materials are mixed according to the proportion, and after the compound vitamin is added, each kilogram of basic diet contains VA 12000IU, VD3 2000IU, VE 20.75mg, VK 3.65 mg, VB12 mg, VB 25mg, VB 62 mg, VB 12.025 mg, biotin 0.0325mg, folic acid 1.25mg, D-pantothenic acid 12mg and nicotinic acid 50mg.
The compound premix provided by the invention can be used for treating broiler pneumonia, and has the advantages of improving immunity, having little side effect, no residue, no drug resistance, no environmental pollution, increasing resistance, rebalancing intestinal flora, improving pneumonic lesions, regulating TLR4 signal paths and the like.
Examples
The embodiment provides a rosmarinic acid premix for relieving lung inflammation of broiler chickens induced by particles, which comprises the following raw materials in parts by weight in every 1000kg of daily ration: 614kg of corn, 308kg of soybean meal, 42kg of soybean oil, 15kg of stone powder, 11kg of calcium hydroxide, 2kg of salt, 2kg of lysine, 1.2kg of methionine, 1.3kg of 50% choline, 3kg of compound premix and 0.5kg of compound vitamin;
wherein each 1kg of the compound premix comprises the following components in parts by weight: 40g of copper sulfate pentahydrate, 120g of ferrous sulfate monohydrate, 170g of manganese sulfate monohydrate, 120g of zinc sulfate monohydrate, 30g of 1% sodium selenite (containing 0.45% of selenium), 10g of 1% potassium iodide (containing 0.76% of iodine), 380g of medical stone and 120g of 10% rosmarinic acid;
the raw materials are mixed according to the proportion, and after the compound vitamin is added, VA 14200IU, VD3 1800IU, VE 20.2mg, VK 32 mg, VB 11mg, VB 2.8 mg, VB 6.8 mg, VB 12.028 mg, biotin 0.03mg, folic acid 1mg, D-pantothenic acid 11mg and nicotinic acid 52mg in each kilogram of basic diet are satisfied.
Examples
The embodiment provides a rosmarinic acid premix for relieving lung inflammation of broiler chickens induced by particles, which comprises the following raw materials in parts by weight in every 1000kg of daily ration: 606kg of corn, 300kg of bean pulp, 50kg of soybean oil, 12kg of stone powder, 20kg of calcium hydroxide, 4kg of salt, 1.3kg of lysine, 2kg of methionine, 1.4kg of 50% choline, 1.3kg of compound premix and 2kg of compound vitamin;
wherein each 1kg of the compound premix comprises the following components in parts by weight: 50g of copper sulfate pentahydrate, 130g of ferrous sulfate monohydrate, 150g of manganese sulfate monohydrate, 110g of zinc sulfate monohydrate, 45g of 1% sodium selenite (containing 0.45% of selenium), 15g of 1% potassium iodide (containing 0.76% of iodine), 400g of medical stone and 100g of 10% rosmarinic acid;
the raw materials are mixed according to the proportion, and after the compound vitamin is added, the vitamin A compound feed meets the requirements of VA 15000IU, VD3 1200IU, VE 22mg, VK 3.2mg, VB 13 mg, VB 2.2 mg, VB6 4mg, VB 12.03 mg, biotin 0.036mg, folic acid 2.1mg, D-pantothenic acid 10.5mg and nicotinic acid 60mg in each kilogram of basic feed.
Examples
The embodiment provides a rosmarinic acid premix for relieving lung inflammation of broiler chickens induced by particles, which comprises the following raw materials in parts by weight in every 1000kg of daily ration: 613.5kg of corn, 310kg of soybean meal, 40kg of soybean oil, 16kg of stone powder, 10kg of calcium hydroxide, 2kg of salt, 1kg of lysine, 4kg of methionine, 1kg of 50% choline, 4kg of compound premix and 1kg of compound vitamin;
wherein each 1kg of the compound premix comprises the following components in parts by weight: 35g of copper sulfate pentahydrate, 150g of ferrous sulfate monohydrate, 165g of manganese sulfate monohydrate, 100g of zinc sulfate monohydrate, 32g of 1% sodium selenite (containing 0.45% of selenium), 18g of 1% potassium iodide (containing 0.76% of iodine), 390g of medical stone and 110g of 10% rosmarinic acid;
the raw materials are mixed according to the proportion, and after the compound vitamin is added, each kilogram of basic diet contains VA 12500IU, VD3 3000IU, VE 21.5mg, VK 3.7 mg, VB 1.6 mg, VB 22mg, VB 6.5 mg, VB 12.026 mg, biotin 0.04mg, folic acid 4mg, D-pantothenic acid 10mg and nicotinic acid 56mg.
To verify the feasibility of the process according to the invention, experiments were carried out on the rosmarinic acid premix described in examples 1-4, the experiments being illustrated as follows:
1. laboratory animals and groups
100 commercial AA meat hatchlings of 1 day old are selected and fed with corn-soybean meal type diet prepared according to the recommended nutrition amounts of the broilers of 1-21 days old and 22-42 days old of U.S. NRC (1994). When the chickens are raised to 14 days of age, 72 chickens with close weight are selected and randomly divided into three groups: control group, PM 2.5 Exposure group, PM 2.5 Exposure + rosmarinic acid group, 6 replicates per group, 4 broilers per replicate.
First, the exposure groups were transferred to 3 identical control rooms from 22 days old after 1 week adaptation in an artificial environment control room, and each PM was produced by a liquid aerosol generator method 2.5 Charging corresponding PM in exposure group 2.5 Concentration (1000 mug/m) 3 PM 2.5 :2 h/d); each control group adopts sterile physiological saline, and PM is monitored in real time during exposure period 2.5 Concentration, test duration, 21 days, feeding management according to the AA broiler feeding management manual.
2. Test design
All broilers were weighed on day 21 of exposure, after which 1 broiler with close weight was randomly selected for fin vein blood sampling in each repetition and supernatant was centrifuged at 3000 r/min and cryopreserved at-20 ℃. After euthanasia of broiler chickens, a small piece of lung tissue was taken, quickly frozen with liquid nitrogen, then stored at-80 ℃, and lung tissue inflammation markers were obtained by a real-time fluorescent quantitative (RT-PCR) method. The cecal content was also taken for analysis of the cecal microbiota.
Analyzing inflammatory factors in blood of broiler chickens by ELISA (enzyme-Linked immuno sorbent assay) method, wherein the inflammatory factors comprise TNF-alpha, IFN gamma, IL-1 beta, IL-6 and IL-10;
analyzing inflammatory factors in the lung of broiler chickens by adopting an RT-PCR technology, wherein the inflammatory factors comprise TNF-alpha, IFN gamma, IL-1 beta, IL-6 and IL-10; and recording the test result.
Analyzing TLR4 signal path factors in broiler lungs by adopting an RT-PCR technology, wherein the TLR4 signal path factors comprise TLR4, myD88 and NF-kB; and recording the test result.
The cecal content flora composition was analyzed using 16S rRNA sequencing technology.
3. Analysis of results:
as shown in fig. 1, the detection result of inflammatory factor in blood of broiler chicken is shown in fig. 2, the detection result of inflammatory factor in lung tissue of broiler chicken is shown in fig. 3, the detection result of TLR4 signal path in lung tissue of broiler chicken is shown in fig. 4, and the detection result of cecum flora of broiler chicken is shown in fig. 5, wherein PM group is PM 2.5 Exposure group, RA group, is feed prepared by using the compound premix raw materials added with rosmarinic acid described in examples 1-4, namely PM 2.5 Exposure + rosmarinic acid group.
According to the graph, after the rosmarinic acid premix prepared by the invention is eaten by broilers, activation of lung TLR4 signal paths is inhibited, the content of inflammatory factors is obviously reduced, intestinal flora is remodeled, the abundance of beneficial bacteria lactic acid bacteria is increased, and the abundance of salmonella is reduced, so that the rosmarinic acid premix for relieving the particulate matter-induced pulmonary inflammation of broilers and remodelling the intestinal flora has obvious effects on treating broiler pneumonia.
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the particular embodiments disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.
Claims (6)
1. A rosmarinic acid premix for alleviating particulate-induced pulmonary inflammation of broilers, comprising: the material consists of the following raw materials in parts by weight: 600-620 parts of corn, 300-310 parts of bean pulp, 40-50 parts of soybean oil, 10-20 parts of stone powder, 10-20 parts of calcium hydride, 1-5 parts of salt, 1-2 parts of lysine, 1-2 parts of methionine, 1-3 parts of 50% choline, 2-4 parts of compound premix and 0.1-2.0 parts of compound vitamin;
the compound premix comprises the following components in parts by weight: 30-50g of copper sulfate pentahydrate, 120-150g of ferrous sulfate monohydrate, 150-170g of manganese sulfate monohydrate, 100-120g of zinc sulfate monohydrate, 30-50g of 1% sodium selenite, 10-20g of 1% potassium iodide, 380-400g of medical stone and 100-120g of 10% rosmarinic acid.
2. The rosmarinic acid premix for alleviating particulate-induced pulmonary inflammation of broilers of claim 1, wherein: after the compound vitamin is added, the compound vitamin meets the requirements of 12000-15000IU, 1000-3000IU, 20-22mg VE, 3 2-3.2mg VK, 1 1-3mg VB2 2-5mg VB6 2-4mg, 0.02-0.03mg VB, 0.03-0.04mg biotin, 1-3mg folic acid, 10-12mg D-pantothenic acid and 50-60mg nicotinic acid in each kilogram of basic ration.
3. The rosmarinic acid premix for alleviating particulate-induced pulmonary inflammation of broilers of claim 1, wherein: the compound premix comprises the following components in parts by weight: 30g of copper sulfate pentahydrate, 140g of ferrous sulfate monohydrate, 160g of manganese sulfate monohydrate, 120g of zinc sulfate monohydrate, 40g of 1% sodium selenite, 20g of 1% potassium iodide, 390g of medical stone and 100g of 10% rosmarinic acid.
4. The rosmarinic acid premix for alleviating particulate-induced pulmonary inflammation of broilers of claim 1, wherein: the compound premix comprises the following components in parts by weight: 40g of copper sulfate pentahydrate, 120g of ferrous sulfate monohydrate, 170g of manganese sulfate monohydrate, 120g of zinc sulfate monohydrate, 30g of 1% sodium selenite, 10g of 1% potassium iodide, 380g of medical stone and 120g of 10% rosmarinic acid.
5. The rosmarinic acid premix for alleviating particulate-induced pulmonary inflammation of broilers of claim 1, wherein: the compound premix comprises the following components in parts by weight: 50g of copper sulfate pentahydrate, 130g of ferrous sulfate monohydrate, 150g of manganese sulfate monohydrate, 110g of zinc sulfate monohydrate, 45g of 1% sodium selenite, 15g of 1% potassium iodide, 400g of medical stone and 100g of 10% rosmarinic acid.
6. The rosmarinic acid premix for alleviating particulate-induced pulmonary inflammation of broilers of claim 1, wherein: the compound premix comprises the following components in parts by weight: 35g of copper sulfate pentahydrate, 150g of ferrous sulfate monohydrate, 165g of manganese sulfate monohydrate, 100g of zinc sulfate monohydrate, 32g of 1% sodium selenite, 18g of 1% potassium iodide, 390g of medical stone and 110g of 10% rosmarinic acid.
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