CN116635401A - 具有改进性能的基因修饰的甲基菌 - Google Patents

具有改进性能的基因修饰的甲基菌 Download PDF

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CN116635401A
CN116635401A CN202180080543.7A CN202180080543A CN116635401A CN 116635401 A CN116635401 A CN 116635401A CN 202180080543 A CN202180080543 A CN 202180080543A CN 116635401 A CN116635401 A CN 116635401A
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亚历山大·约翰尼斯·克鲁伊斯
戴维·维兰特
亚卡·霍瓦特
托尼·纳戈德
斯蒂芬·富伊斯
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Abstract

本发明总体涉及生物技术工程，并且特别涉及基因修饰的甲基菌属的细菌，其具有改进的性能，使其在大规模甲醇发酵中特别有用。更具体地，本发明提供了一种甲基菌属的细菌，该细菌与不携带所述修饰的其他相同的细菌相比，修饰为具有降低的胞外多糖(EPS)的生产。本发明还提供了一种使用本发明的基因修饰的细菌生产生物化学化合物的方法。

Description

具有改进性能的基因修饰的甲基菌
技术领域
本发明通常涉及生物技术工程，特别是甲基菌(Methylobacillus)属的基因修饰的细菌，其具有改进的性能，使其在大规模甲醇发酵中特别有用。更具体地，本发明提供了一种甲基菌属的细菌，其与不携带所述修饰的其他相同的细菌相比，该细菌修饰为具有降低的胞外多糖(EPS)生产。本发明还提供了一种使用本发明的基因修饰的细菌生产生物化学化合物的方法。
背景技术
甲醇发酵有取代石油化工生产的前景。为了实现这一点，必须开发高效的甲基营养菌株(消耗甲醇或甲烷等单碳化合物或不含碳-碳键的多碳化合物)。目前已经确定出了几种能够利用甲醇作为生长和产物形成的唯一碳源的细菌。一些例子包括甲醇芽孢杆菌(Bacillus methanolicus)、扭脱甲基杆菌(Methylobacterium extorquens)、糖原甲基菌(Methylobacillus glycogenes)和鞭毛甲基菌(Methylobacillus flagellatus)。基于甲醇同化途径，甲基营养细菌可以分为两大类。第一步总是在甲醇脱氢酶的催化下将甲醇转化为甲醛。在第一类中，甲醛与单磷酸核糖(RuMP)反应形成C6化合物，然后进一步代谢。这一类的成员通常被称为“RuMP循环甲基营养菌”。第二类包括扭脱甲基杆菌，其通过使甲醛与甘氨酸反应而吸收消化甲醛，在被称为丝氨酸循环的途径中形成丝氨酸。这两类甲基营养菌都已用于由甲醇生产各种生物化学品。然而，RuMP循环比丝氨酸循环更节能，导致生长和生物质形成更快。
在海洋、土壤、植物根际甚至生活污水等极其多样化的环境中都可以发现甲基营养微生物。由于甲基营养菌必须可以在这些多样且往往恶劣的环境中生存，则它们往往非常强健，可以抵抗不同类型的压力，而同时在最低限度的营养下高效生长。来自RuMP循环利用型甲基菌属的菌株具有生化生产流程所需的许多性状；它们在最低矿物介质中快速而可重复生长，并且它们对温度和甲醇浓度的波动不敏感。此外，它们非常适合基因操纵，释放复杂途径代谢工程化的潜力。
包括甲基菌在内的许多甲基营养菌产生大量的胞外多糖(EPS)，这为生物体在自然环境中提供了多种优势，如防止干燥、生物膜支架形成、能量储备等。在补料分批发酵中，甲基菌生物质可以包含高达30％的EPS。
相对而言，还未对甲基菌中的EPS生产作专门研究。研究还只停留于单菌株，即甲基菌属菌株12S，一种从土壤中分离出的专性甲基营养菌，发现其可以合成称为甲氧烷(methanolan)的新型EPS(Yoshida et al，2000)。虽然已经识别并表征了甲基菌菌株12S中负责甲氧烷合成的基因簇(Yoshida et al，2003)，但尚未在其他甲基菌中进行此类工作。基于生物信息学分析和序列相似性，已经预测了鞭毛甲基菌KT菌株(Chistoserdova etal.，2007)和糖原甲基菌(Hattori et al.，2020)中的EPS基因簇，但这些基因本身还从未被表征。
发明内容
本发明的目的是克服基于甲醇的生物过程中的某些缺点。这由本发明人实现，本发明人工程化了具有降低的胞外多糖(EPS)生产的不同的基因修饰的甲基菌属的细菌。
本发明人研究了甲基菌中的通用EPS生产。基于对鞭毛甲基菌和糖原甲基菌基因组的生物信息学分析，本发明人识别出了两个推定的生产EPS的基因簇。两个EPS簇的中断会导致EPS生产的完全消除。
在修饰的鞭毛甲基菌和糖原甲基菌菌株中，观察到的出乎意料且预料不到的结果是它们在生长培养物中的行为。当在甲基菌中消除一种或多种参与胞外多糖(EPS)生产的内源性多肽的表达时，培养物显示出许多有利于基于甲醇的生物过程的开发的出乎意料且预料不到的性能。出乎意料的是，摇瓶和生物反应器中过量的培养物起泡降低。此外，虽然在未修饰的亲本菌株中观察到细胞聚结(cell clumping)，但在修饰的甲基菌的培养中，这种聚结降低，甚至不存在。当EPS生产被消除时，生物质的离心和过滤也得以改善。这些综合特性显著改善了生物过程、菌株处理和下游加工，使修饰的甲基菌适合大规模甲醇发酵。消除EPS合成也出乎意料地提高了鞭毛甲基菌和其他甲基菌物种的甲醇耐受性。
基于上述发现，本发明在第一方面中提供了一种基因工程化的甲基菌属的细菌，其修饰为与不携带所述修饰的其他相同的细菌相比具有降低的胞外多糖(EPS)生产。
本发明还提供了一种生产生物化学化合物的方法，包括：在合适的培养条件下，在包含还原的(reduced)单碳化合物如甲醇，或不含碳-碳键的多碳化合物如二甲胺的培养基中培养本发明的细菌。
本发明可以通过以下条款概述：
1.一种基因修饰的甲基菌属的细菌，其与不携带所述修饰的其他相同的细菌相比，该基因修饰的细菌修饰为降低胞外多糖(EPS)生产。
2.根据第1款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中至少一种参与胞外多糖(EPS)生产的内源性多肽的表达和/或功能(例如，活性)。
3.根据第1或2款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中至少一种参与胞外多糖(EPS)生产的内源性多肽的表达。
4.根据第1-3款中任一款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中至少两种参与胞外多糖(EPS)生产的内源性多肽的表达。
5.根据第1-4款中任一款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中至少三种参与胞外多糖(EPS)生产的内源性多肽的表达。
6.根据第1-5款中任一款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中至少四种参与胞外多糖(EPS)生产的内源性多肽的表达。
7.根据第1-6款中任一款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中至少五种参与胞外多糖(EPS)生产的内源性多肽的表达。
8.根据第1-7款中任一款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中至少六种参与胞外多糖(EPS)生产的内源性多肽的表达。
9.根据第1-8款中任一款所述的细菌，与不携带所述修饰的其他相同的细菌(参考细菌)相比，该细菌修饰为降低所述细菌中所有参与胞外多糖(EPS)生产的内源性多肽的表达。
10.根据第2-9款中任一款所述的细菌，其中所述至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:1-38中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:1-38中任一个具有至少70％序列同一性的氨基酸序列并具有与参考多肽相同的功能特性的多肽。
11.根据第2-10款中任一款所述的细菌，其中所述至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:1-26中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:1-26中任一个具有至少70％序列同一性的氨基酸序列并具有与参考多肽相同的功能特性的多肽。
12.根据第2-10款中任一款所述的细菌，其中所述至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:27-38中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:127-38中任何一个具有至少70％序列同一性的氨基酸序列并具有与参考多肽相同的功能特性的多肽。
13.根据第2-12款中任一款所述的细菌，其中所述至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自有以下组成的组：a)包含SEQ ID NO:39-86中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:39-86中任一个具有至少70％序列同一性的氨基酸序列并具有与参考多肽相同的功能特性的多肽。
14.根据第2-13款中任一款所述的细菌，其中所述至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:39-60中任一个所述的氨基酸序列的多肽，和b)包含与SEQ IDNO:39-60中任一个具有至少70％序列同一性的氨基酸序列并具有与参考多肽相同的功能特性的多肽。
15.根据第2-13款中任一款所述的细菌，其中所述至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自有以下组成的组：a)包含SEQ ID NO:61-86中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:61-86中任一个具有至少70％序列同一性的氨基酸序列并具有与参考多肽相同的功能特性的多肽。
16.根据第2-15款中任一款所述的细菌，其中所述至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：具有肽基-脯氨酰基顺-反异构酶(peptidyl-prolyl cis-trans isomerase)活性的多肽；可以充当多糖输出的多肽；作用为链长决定蛋白的多肽；和具有蛋白-酪氨酸激酶活性的多肽。
17.根据第16款所述的细菌，其中所述具有肽基-脯氨酰顺-反异构酶活性的多肽包含与SEQ ID NO:6具有至少70％序列同一性的氨基酸序列，所述可以充当多糖输出的多肽包含具有与SEQ ID NO:7具有至少70％序列同一性的氨基酸序列，所述作用为链长决定蛋白的多肽包括与SEQ ID NO:8具有至少70％序列同一性的氨基酸序列，并且所述具有蛋白-酪氨酸激酶活性的多肽包含与SEQ ID NO:9具有至少70％序列同一性的氨基酸序列。
18.根据第16款所述的细菌，其中所述具有肽基-脯氨酰基顺-反异构酶活性的多肽包含与SEQ ID NO:42具有至少70％序列同一性的氨基酸序列，所述可以充当多糖输出的多肽包含具有与SEQ ID NO:43至少70％序列同一性的氨基酸序列，所述作用为链长决定蛋白的多肽包含与SEQ ID NO:44具有至少70％序列同一性的氨基酸序列，并且所述具有蛋白-酪氨酸激酶活性的多肽包含与SEQ ID NO:45具有至少70％序列同一性的氨基酸序列。
19.根据第2-18款中任一款所述的细菌，其中所述细菌中参与胞外多糖(EPS)生产的至少一种多肽的表达降低了至少50％，例如，至少60％、至少65％、至少70％、至少75％、至少80％、至少85％、至少90％、至少95％或至少100％。
20.根据第2-19款中任一款所述的细菌，其中与其他相同的细菌相比，该细菌中至少一种参与胞外多糖(EPS)生产的多肽的表达被消除。
21.根据第2-20款中任一款所述的细菌，其中编码所述参与该细菌中胞外多糖(EPS)生产的多肽的内源性基因被灭活。
22.根据第2-21款中任一款所述的细菌，其中所述编码参与该细菌中胞外多糖(EPS)生产的多肽的内源性基因通过缺失部分或全部基因序列而失灭活。
23.根据第2-22款中任一款所述的细菌，其中通过在该细菌中引入或表达可以通过DNA切割选择性灭活编码所述多肽的内源基因的相应稀切核酸内切酶，灭活编码所述参与该细菌胞外多糖(EPS)生产的多肽的内源性基因。
24.根据第23款的细菌，其中所述稀切核酸内切酶选自由转录激活子样效应器(TALE)核酸酶、巨核酸酶、锌指核酸酶(ZFN)和RNA引导核酸内切酶组成的组。
25.根据第24款所述的细菌，其中所述RNA引导核酸内切酶是催化灭活的Cas9蛋白。
26.根据第25款所述的细菌，其包含(例如，表达)至少一种在细胞条件下与编码所述酶的基因组DNA特异性杂交(例如，结合)的单引导RNA(sgRNA)。
27.根据第2-21款中任一款所述的细菌，其中所述细菌中参与胞外多糖(EPS)生产的多肽的表达通过编码所述多肽的内源性基因的转录和/或翻译抑制而降低(例如，被抑制)。
28.根据第2-21款中任一款所述的细菌，其中所述细菌中参与胞外多糖(EPS)生产的多肽的表达通过在该细菌中引入或表达至少一种在细胞条件下与编码所述多肽的细胞mRNA和/或基因组DNA特异性杂交(例如，结合)的抑制性核酸分子而降低(例如，被抑制)。
29.根据第28款的细菌，其中所述抑制性核酸分子是反义寡核苷酸、核酶或干扰RNA(RNAi)分子。
30.根据第29款所述的细菌，其中所述干扰RNA分子是微RNA(miRNA)、小干扰RNA(siRNA)或短发夹RNA(shRNA)。
31.根据第2-30款中任一款所述的细菌，其中所述细菌中一种或多种参与胞外多糖(EPS)生产的内源性多肽由第一EPS基因簇和/或第二EPS基因簇中包含的一个或多个基因进行编码。
32.根据第31款所述的细菌，其中所述第一EPS基因簇包括由SEQ ID NO:174或177中存在的开放阅读框(ORF)定义或与其同源的基因。
33.根据第31或32款所述的细菌，其中所述第一EPS基因簇包括基因epsD、epsE、epsF、epsG、epsB、epsL、epsH、epsI、epsJ和epsS，或其直系同源物。
34.根据第31-33款中任一款所述的细菌，其中所述第一EPS基因簇包括基因epsD、epsE、epsF和epsG，或其直系同源物。
35.根据第31-34款中任一款所述的细菌，其中所述第一EPS基因簇包括与SEQ IDNO:174或177的核苷酸序列具有至少50％序列同一性的核苷酸序列。
36.根据第31-34款中任一款所述的细菌，其中所述第一EPS基因簇包括与SEQ IDNO:174的核苷酸序列具有至少50％序列同一性的核苷酸序列。
37.根据第31-36款中任一款所述的细菌，其中所述第一EPS基因簇中的至少一个基因，例如，通过缺失部分或全部基因序列而被灭活。
38.根据第31-37款中任一款所述的细菌，其中至少一个选自epsD、epsE、epsF、epsG、epsB、epsL、epsH、epsI、epsJ和epsS的基因或其直系同源物，例如，通过缺失部分或全部基因序列而被灭活。
39.根据第31-38款中任一款所述的细菌，其中至少一个选自epsD、epsE、epsF和epsG的基因或其直系同源物，例如，通过缺失部分或全部基因序列而被灭活。
40.根据第31-39款中任一款所述的细菌，其中所述基因epsD、epsE、epsF和epsG或其直系同源物，例如，通过缺失部分或全部基因序列而被灭活。
41.根据第39或40款所述的细菌，其中所述基因epsD会编码包含与SEQ ID NO:6具有至少70％序列同一性的氨基酸序列的多肽，其中所述基因epsE会编码包含与SEQ ID NO:7具有至少70％序列同一性的氨基酸序列的多肽，其中所述基因epsF会编码包含与SEQ IDNO:8具有至少70％序列同一性的氨基酸序列的多肽，并且其中所述基因epsG会编码包含与SEQ ID NO:9具有至少70％序列同一性的氨基酸序列的多肽。
42.根据第41款所述的细菌，其中所述基因epsD包含与SEQ ID NO:92具有至少70％序列同一性的核苷酸序列，所述基因epsE包含与SEQ ID NO:93具有至少70％序列同一性的核苷酸序列，并且所述基因epsG包含与SEQ ID NO:95具有至少70％序列同一性的核苷酸序列。
43.根据第39或40款所述的细菌，其中所述基因epsD会编码包含与SEQ ID NO:42具有至少70％序列同一性的氨基酸序列的多肽，其中所述基因epsE会编码包含与SEQ IDNO:43具有至少70％序列同一性的氨基酸序列的多肽，其中所述基因epsF会编码包含与SEQID NO:44具有至少70％序列同一性的氨基酸序列的多肽，并且其中所述基因epsG会编码包含与SEQ ID NO:45具有至少70％序列同一性的氨基酸序列的多肽。
44.根据第43款所述的细菌，其中epsD基因包含与SEQ ID NO:128具有至少70％序列同一性的核苷酸序列，所述基因epsE包含与SEQ ID NO:129具有至少70％序列同一性的核苷酸序列，所述基因epsF包含与SEQ ID NO:130具有至少70％序列同一性的核苷酸序列，并且所述基因epsG包含与SEQ ID NO:131具有至少70％序列同一性的核苷酸序列。
45.根据第31-44款中任一款所述的细菌，其中所述第一EPS基因簇被灭活。
46.根据第31-45款中任一款所述的细菌，其中所述第一EPS基因簇通过所述簇的部分或整个序列缺失而灭活。
47.根据第31-45款中任一款所述的细菌，其中所述第一EPS基因簇通过修饰(例如，通过在其中引入至少一种突变)启动子和/或核糖体结合位点区域导致基因表达缺乏而灭活。
48.根据第31-47款中任一款所述的细菌，其中所述第二EPS基因簇包括由SEQ IDNO:175或179中存在的开放阅读框(ORF)定义或与其同源的基因。
49.根据第31-48款中任一款所述的细菌，其中所述第二EPS基因簇包括与SEQ IDNO:175或179的核苷酸序列具有至少50％序列同一性的核苷酸序列。
50.根据第31-48款中任一款所述的细菌，其中所述第二EPS基因簇包括与SEQ IDNO:175的核苷酸序列具有至少50％序列同一性的核苷酸序列。
51.根据第31-50款中任一款所述的细菌，其中所述第二EPS基因簇中的至少一个基因，通过例如缺失部分或全部基因序列而灭活。
52.根据第31-51款中任一款所述的细菌，其中所述第二EPS基因簇被灭活。
53.根据第31-52款中任一款所述的细菌，其中所述第二EPS基因簇通过所述簇的部分或整个序列的缺失而被灭活。
54.根据第31-52款中任一款所述的细菌，其中所述第二EPS基因簇通过修饰(例如，通过在其中引入至少一种突变)启动子和/或核糖体结合位点区域导致基因表达的缺乏而灭活。
55.根据第1-52中任一款所述的细菌，其中编码参与所述细菌中胞外多糖(EPS)生产的酶的所有内源基因被灭活，例如缺失。
56.根据第1-55款中任一款所述的细菌，其中所述细菌选自鞭毛甲基菌(Methylobacillus flagellatus)、糖原甲基菌(Methylobacillus glycogenes)、草原甲基菌(Methylobacillus pratensis)、根际甲基菌(Methylobacillus rhizosphaerae)、草状甲基菌(Methylobacillus gramineus)、树状甲基菌(Methylobacillus arboreus)、隆凸甲基菌(Methylobacillus caricics)、食甲基甲基菌(Methylobacillus methilovorans)和甲基菌属(Methylobacillus sp)。
57.根据第1-56款中任一款所述的细菌，其中所述细菌选自鞭毛甲基菌和糖原甲基菌。
58.根据第1-55款中任一款所述的细菌，其中所述细菌是鞭毛甲基菌。
59.根据第1-55款中任一款所述的细菌，其中所述细菌是糖原甲基菌。
60.一种生产生物化学化合物的方法，包括在合适的培养条件下，在包含还原的单碳化合物如甲醇或不含碳-碳键的多碳化合物如二甲胺的培养基中培养第1-59款中任一款所述的细菌。
61.根据第60款所述的方法，其中所述培养基包含甲醇。
62.根据第60或61款所述的方法，其中所述培养在生物反应器中进行。
63.根据第60-62款中任一款所述的方法，其中所述生物化学化合物选自有机酸、氨基酸、脂肪酸及其衍生物。
附图说明
图1：水解的鞭毛甲基菌摇瓶上清液的糖含量。深灰色条表示以mg/L计的总葡萄糖，浅灰色条表示总单糖。误差条是技术性复制品的标准偏差。
图2：由不同鞭毛甲基菌的菌株生产的生物反应器液的测量粘度。
图3：野生型鞭毛甲基菌和糖原甲基菌培养24小时后的照片。左侧为野生型ABME 5和6，随后是鞭毛甲基菌的单簇破坏，最后是双簇破坏。
图4：ABME 6和ABME 131两种代表性生物反应器发酵期间消泡剂添加量(y轴)相对于发酵时间(x轴)的图表。
图5：野生型鞭毛甲基菌的生物反应器发酵液(左)与双簇破坏菌株ABME 131(右)的相差显微镜图像。
图6：与亲本菌株相比，无EPS的ABME131的生长得到改善。
现在将在下面更详细地描述本发明。
具体实施方式
除非本文中有明确定义，否则所使用的所有技术和科学术语具有与生物化学、遗传学和微生物学领域的技术人员通常理解的含义相同的含义。
与本文所述方法和材料相似或等效的所有方法和材料，采用本文描述的合适方法和材料都可以用于本发明的实践或测试。本文提及的所有出版物、专利申请、专利和其他参考文献都以引用方式以其全部内容结合于本文中。如有冲突，以包括定义在内的本说明书为准。此外，除非另有规定，否则材料、方法和实施例仅为举例说明性的，而非旨在进行限制。
除非另有说明，否则本发明的实践将采用本领域技术范围内的细胞生物学、细胞培养、分子生物学、基因修饰的生物学、微生物学和重组DNA的常规技术。这些技术在文献中有充分解释。例如，参见Current Protocols in Molecular Biology(FrederickM.AUSUBEL,2000,Wiley and son Inc,Library of Congress,USA)；Molecular Cloning:ALaboratory Manual,Third Edition,(Sambrook et al,2001,Cold Spring Harbor,NewYork:Cold Spring Harbor Laboratory Press)；Oligonucleotide Synthesis(M.J.Gaited.,1984)；Mullis et al.U.S.Pat.No.4,683,195；Nucleic Acid Hybridization(B.D.Harries&S.J.Higgins eds.1984)；Transcription And Translation(B.D.Hames&S.J.Higgins eds.1984)；Culture Of Animal Cells(R.I.Freshney,Alan R.Liss,Inc.,1987)；Immobilized Cells And Enzymes(IRL Press,1986)；B.Perbal,A PracticalGuide To Molecular Cloning(1984)；the series,Methods In ENZYMOLOGY(J.Abelsonand M.Simon,eds.-in-chief,Academic Press,Inc.,New York),specifically,Vols.154and 155(Wu et al.eds.)and Vol.185,"Gene Expression Technology"(D.Goeddel,ed.)；Gene Transfer Vectors For Mammalian Cells(J.H.Miller andM.P.Calos eds.,1987,Cold Spring Harbor Laboratory)。
本发明的细菌
如上所述，本发明基于出乎意料且预料不到的发现，即基于甲醇的生物过程中的某些缺点可以通过下调甲基菌属的细菌中的胞外多糖(EPS)生产而克服。
因此，本发明在第一方面中提供了一种基因修饰的甲基菌属的细菌，其经过修饰为与不携带所述修饰的其他相同的细菌相比具有降低的胞外多糖(EPS)生产。
更具体地，本发明提供了一种基因修饰的甲基菌属的细菌，其修饰为与不携带所述修饰的其他相同的细菌(参考细菌)相比具有降低的所述细菌中至少一种参与胞外多糖(EPS)生产的内源性多肽的表达和/或活性。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少一种，例如至少两种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少三种，例如至少四种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少五种，例如至少六种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少七种，例如至少八种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少九种，例如至少十种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少十一种，例如至少十二种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少十三种，例如至少十四种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了至少十五种，例如至少十六种，参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，与不携带所述修饰的其他相同的细菌(参考细菌)相比，本发明的基因修饰的细菌修饰为降低了所有参与所述细菌中胞外多糖(EPS)生产的内源性多肽的表达。
根据一些实施方式，至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:1-38中任一个所述的氨基酸序列的多肽，和b)包含与SEQID NO:1-38中任一个具有至少70％，例如，至少75％，至少80％，至少85％，至少90％或至少95％序列同一性的氨基酸序列并且具有与参考多肽相同的功能性质的多肽。
根据一些实施方式，至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:1-26中任一个所述的氨基酸序列的多肽，和b)包含与SEQID NO:1-26中任一个具有至少70％，例如，至少75％，至少80％，至少85％，至少90％或至少95％序列同一性的氨基酸序列并且具有与参考多肽相同的功能性质的多肽。
根据一些实施方式，至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:27-38中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:27-38中任一个具有至少70％，例如，至少75％，至少80％，至少85％，至少90％或至少95％序列同一性的氨基酸序列并且具有与参考多肽相同的功能性质的多肽。
根据一些实施方式，至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:39-86中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:39-86中任一个具有至少70％，例如，至少75％，至少80％，至少85％，至少90％或至少95％序列同一性的氨基酸序列并且具有与参考多肽相同的功能性质的多肽。
根据一些实施方式，至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:39-60中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:39-60中任一个具有至少70％，例如，至少75％，至少80％，至少85％，至少90％或至少95％序列同一性的氨基酸序列并且具有与参考多肽相同的功能性质的多肽。
根据一些实施方式，至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：a)包含SEQ ID NO:61-86中任一个所述的氨基酸序列的多肽，和b)包含与SEQ ID NO:61-86中任一个具有至少70％，例如，至少75％，至少80％，至少85％，至少90％或至少95％序列同一性的氨基酸序列并且具有与参考多肽相同的功能性质的多肽。
根据一些实施方式，至少一种参与所述细菌中胞外多糖(EPS)生产的多肽选自由以下组成的组：具有肽基-脯氨酰基顺-反异构酶活性的多肽、可以充当多糖输出的多肽；作用为链长决定蛋白的多肽；和具有蛋白-酪氨酸激酶活性的多肽。
根据一些实施方式，具有肽基-脯氨酰基顺-反异构酶活性的多肽包含与SEQ IDNO:6具有至少70％序列同一性的氨基酸序列。
根据一些实施方式，可以充当多糖输出其的多肽包含与SEQ ID NO:7具有至少70％序列同一性的氨基酸序列。
根据一些实施方式，作用为链长决定蛋白的多肽包含与SEQ ID NO:8具有至少70％序列同一性的氨基酸序列。
根据一些实施方式，具有蛋白-酪氨酸激酶活性的多肽包含与SEQ ID NO:9具有至少70％序列同一性的氨基酸序列。
根据一些实施方式，具有肽基-脯氨酰基顺-反异构酶活性的多肽包含与SEQ IDNO:42具有至少70％序列同一性的氨基酸序列。
根据一些实施方式，可以充当多糖输出的多肽包含与SEQ ID NO:43具有至少70％序列同一性的氨基酸序列。
根据一些实施方式，作用为链长决定蛋白的多肽包含与SEQ ID NO:44具有至少70％序列同一性的氨基酸序列。
根据一些实施方式，具有蛋白-酪氨酸激酶活性的多肽包含与SEQ ID NO:45具有至少70％序列同一性的氨基酸序列。
与其他相同的细菌相比，该内源性多肽的表达水平可以例如降低至少50％，例如，至少60％、至少65％、至少70％、至少75％、至少80％、至少85％、至少90％、至少95％或至少100％。
内源性多肽表达的降低可以通过本领域已知的任何合适方法实现。例如，通过灭活编码所述参与该细菌中胞外多糖(EPS)生产的多肽的内源性基因，例如，通过缺失部分或全部基因序列，可以降低表达。
根据一些实施方式，与其他相同的细菌相比，所述细菌中至少一种参与胞外多糖(EPS)生产的多肽的表达被消除。
根据一些实施方式，编码参与该细菌中胞外多糖(EPS)生产的多肽的内源性基因通过例如缺失部分或整个基因序列而灭活。
根据一些实施方式，编码参与所述细菌中胞外多糖(EPS)生产的多肽的内源性基因已通过在细菌中引入或表达可以通过DNA切割选择性灭活编码所述酶的内源性基因的稀切核酸内切酶而灭活。根据本发明用于灭活内源性基因的稀切核酸内切酶可以是例如转录激活子样效应子(TALE)核酸酶、巨核酸酶、锌指核酸酶(ZFN)或RNA引导核酸内切酶。
一种灭活编码参与所述细菌胞外多糖(EPS)生产的多肽的内源性基因的方法是使用CRISPRi系统。CRISPRi系统作为靶向抑制基因表达或阻断基因组靶向位置的工具而开发。CRISPRi系统由催化失活的“死亡”Cas9蛋白(dCas9)和定义dCas9与DNA结合位点的引导RNA组成。
根据一些实施方式，通过抑制方式降低细菌中参与胞外多糖(EPS)生产的内源性多肽的表达。
可以通过本领域已知的任何合适手段抑制多肽的表达。例如，通过涉及使用抑制性核酸分子，如反义寡核苷酸、核酶或干扰RNA(RNAi)分子，如微RNA(miRNA)，小干扰RNA(siRNA)或短发夹RNA(shRNA)的基因沉默技术可以抑制该表达。
根据一些实施方式，参与细菌中胞外多糖(EPS)生产的内源性多肽的表达通过编码所述多肽的内源性基因的转录和/或翻译抑制而降低(例如抑制)。
根据一些实施方式，通过在细菌中引入或表达抑制性核酸分子，抑制该细菌中参与胞外多糖(EPS)生产的内源性多肽的表达。例如，抑制性核酸分子可以通过包含编码可操作地连接至细菌中引起所述抑制性核酸分子产生的功能的启动子如诱导型启动子的所述抑制性核酸分子的核苷酸序列的外源核酸分子的方式引入。合适的是，该抑制性核酸分子是在细胞条件下与编码关注的内源性多肽的细胞mRNA和/或基因组DNA特异性杂交(例如结合)的核酸分子。取决于靶标，编码基因组DNA的转录和/或编码mRNA的翻译会受到抑制。
根据一些实施方式，抑制性核酸分子是反义寡核苷酸、核酶或干扰RNA(RNAi)分子。优选地，这样的核酸分子包含编码所关注多肽的细胞mRNA和/或基因组DNA的补体的至少10个连续核苷酸。
根据一些实施方式，该抑制性核酸是反义寡核苷酸。这种反义寡核苷酸是在细胞条件下与编码所关注酶的细胞mRNA和/或基因组DNA特异性杂交(例如，结合)的核酸分子(DNA或RNA)。
根据一些实施方式，该抑制性核酸分子是核酶，如锤头状核酶。核酶分子设计为催化切割mRNA转录物而防止所关注的多肽的翻译。
根据一些实施方式，抑制性核酸分子是干扰RNA(RNAi)分子。RNA干扰是其中RNA分子抑制表达的生物过程，通常会导致特定mRNA的破坏。RNAi分子的示例性类型包括微RNA(miRNA)、小干扰RNA(siRNA)和短发夹RNA(shRNA)。根据一些实施方式，RNAi分子是miRNA。根据一些实施方式，RNAi分子是siRNA。根据一些实施方式，RNAi分子是shRNA。
根据一些实施方式，与不携带所述修饰的其他相同的微生物(参考细菌)相比，本发明的细菌修饰为降低至少一种参与该细菌中胞外多糖(EPS)生产的多肽的功能(例如，活性)。
至少一种内源性多肽的功能(例如，活性)的降低可以通过本领域已知的任何合适的手段实现。例如，如果多肽是一种酶，则通过在该酶的活性位点中引入一个或多个导致活性降低或丧失的突变来降低活性。因此，根据一些实施方式，至少一种参与细菌中胞外多糖(EPS)生产的内源性酶的活性通过至少一个导致活性降低或丧失的活性位点突变而降低。至少一个活性位点突变可以是例如至少一个非保守氨基酸取代。
如上所述，本发明人已经在甲基菌的基因组中确定出了两种推定的EPS基因簇。参与胞外多糖(EPS)生产的一种或多种内源性多肽因此由包括在第一EPS基因簇和/或第二EPS基因簇中的一个或多个基因编码。
根据一些实施方式，参与该细菌中胞外多糖(EPS)生产的内源性多肽由包括在第一EPS基因簇和/或第二EPS基因簇中的一个或多个基因编码。
根据一些实施方式，第一EPS基因簇包括由SEQ ID NO:174或177中存在的开放阅读框(ORF)定义的或与其同源的基因。
根据一些实施方式，第一EPS基因簇包括基因epsD、epsE、epsF、epsG、epsB、epsL、epsH、epsI、epsJ和epsS，或其直系同源物。
根据一些实施方式，第一EPS基因簇包括基因epsD、epsE、epsF和epsG，或其直系同源物。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:174或177的核苷酸序列具有至少50％，例如至少55％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:174或177的核苷酸序列具有至少60％，例如至少65％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:174或177的核苷酸序列具有至少70％，例如至少75％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:174或177的核苷酸序列具有至少80％，例如至少85％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:174或177的核苷酸序列具有至少90％，例如至少93％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:174或177的核苷酸序列具有至少95％，例如至少97％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:174的核苷酸序列具有至少50％，如至少51％、至少52％、至少53％、至少54％、至少55％、至少56％、至少57％、至少58％、至少59％、至少60％、至少61％、至少62％、至少63％、至少64％、至少65％、至少66％、至少67％、至少68％、至少69％、至少70％、至少71％、至少72％、至少73％、至少74％、至少75％、至少76％、至少77％、至少78％、至少79％、至少80％、至少81％、至少82％、至少83％、至少84％、至少85％、至少86％、至少87％、至少88％、至少89％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％或至少99％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇包括与SEQ ID NO:177的核苷酸序列具有至少50％，如至少51％、至少52％、至少53％、至少54％、至少55％、至少56％、至少57％、至少58％、至少59％、至少60％、至少61％、至少62％、至少63％、至少64％、至少65％、至少66％、至少67％、至少68％、至少69％、至少70％、至少71％、至少72％、至少73％、至少74％、至少75％、至少76％、至少77％、至少78％、至少79％、至少80％、至少81％、至少82％、至少83％、至少84％、至少85％、至少86％、至少87％、至少88％、至少89％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％或至少99％序列同一性的核苷酸序列。
根据一些实施方式，第二EPS基因簇包括由SEQ ID NO:175或179中存在的开放阅读框(ORF)定义的或与其同源的基因。
根据一些实施方式，第二EPS基因簇包括与SEQ ID NO:175或179的核苷酸序列具有至少50％，如至少55％序列同一性的核苷酸序列。
根据一些实施方式，第二EPS基因簇包括与SEQ ID NO:175或179的核苷酸序列具有至少60％，如至少65％序列同一性的核苷酸序列。
根据一些实施方式，第二EPS基因簇包括与SEQ ID NO:175或179的核苷酸序列具有至少70％，如至少75％序列同一性的核苷酸序列。
根据一些实施方式，第二EPS基因簇包括与SEQ ID NO:175或179的核苷酸序列具有至少80％，如至少85％序列同一性的核苷酸序列。
根据一些实施方式，第二EPS基因簇包括与SEQ ID NO:175或179的核苷酸序列具有至少90％，如至少95％序列同一性的核苷酸序列。
根据一些实施方式，第二EPS基因簇包括与SEQ ID NO:175的核苷酸序列具有至少50％，如至少51％、至少52％、至少53％、至少54％、至少55％、至少56％、至少57％、至少58％、至少59％、至少60％、至少61％、至少62％、至少63％、至少64％、至少65％、至少66％、至少67％、至少68％、至少69％、至少70％、至少71％、至少72％、至少73％、至少74％、至少75％、至少76％、至少77％、至少78％、至少79％、至少80％、至少81％、至少82％、至少83％、至少84％、至少85％、至少86％、至少87％、至少88％、至少89％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％或至少99％序列同一性的核苷酸序列。
根据一些实施方式，第二EPS基因簇包括与SEQ ID NO:179的核苷酸序列具有至少50％，如至少51％、至少52％、至少53％、至少54％、至少55％、至少56％、至少57％、至少58％、至少59％、至少60％、至少61％、至少62％、至少63％、至少64％、至少65％、至少66％、至少67％、至少68％、至少69％、至少70％、至少71％、至少72％、至少73％、至少74％、至少75％、至少76％、至少77％、至少78％、至少79％、至少80％、至少81％、至少82％、至少83％、至少84％、至少85％、至少86％、至少87％、至少88％、至少89％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％或至少99％序列同一性的核苷酸序列。
根据一些实施方式，第一EPS基因簇中的至少一个基因，通过例如部分或整个基因序列的缺失而被灭活。
根据一些实施方式，所述至少一个基因选自epsD、epsE、epsF、epsG、epsB、epsL、epsH、epsI、epsJ和epsS，或其直系同源物。
根据一些实施方式，所述至少一个基因选自epsD、epsE、epsF和epsG，或其直系同源物。
根据一些实施方式，基因epsD、epsE、epsF和epsG或其直系同源物通过例如部分或整个基因序列缺失而被灭活。
根据一些实施方式，基因epsD编码包含与SEQ ID NO:6具有至少70％，如至少75％序列同一性的氨基酸序列的多肽，基因epsE编码包含与SEQ ID NO:7具有至少70％，如至少75％序列同一性的氨基酸序列的多肽，基因epsF编码包含与SEQ ID NO:8具有至少70％，如至少75％序列同一性的氨基酸序列的多肽，而基因epsG编码包含与SEQ ID NO:9具有至少70％，如至少75％序列同一性的氨基酸序列的多肽。
根据一些实施方式，基因epsD编码包含与SEQ ID NO:6具有至少80％，如至少85％序列同一性的氨基酸序列的多肽，基因epsE编码包含与SEQ ID NO:7具有至少80％，如至少85％序列同一性的氨基酸序列的多肽，基因epsF编码包含与SEQ ID NO:8具有至少80％，如至少85％序列同一性的氨基酸序列的多肽，而基因epsG编码包含与SEQ ID NO:9具有至少80％，如至少85％序列同一性的氨基酸序列的多肽。
根据一些实施方式，基因epsD编码包含与SEQ ID NO:6具有至少90％，如至少95％序列同一性的氨基酸序列的多肽，基因epsE编码包含与SEQ ID NO:7具有至少90％，如至少95％序列同一性的氨基酸序列的多肽，基因epsF编码包含与SEQ ID NO:8具有至少90％，如至少95％序列同一性的氨基酸序列的多肽，而基因epsG编码包含与SEQ ID NO:9具有至少90％，如至少95％序列同一性的氨基酸序列的多肽。
根据一些实施方式，epsD基因包含与SEQ ID NO:92具有至少70％，如至少75％序列同一性的核苷酸序列，基因epsE包含与SEQ ID NO:93具有至少70％，如至少75％序列同一性的核苷酸序列，基因epsF包含与SEQ ID NO:94具有至少70％，如至少75％序列同一性的核苷酸序列，而基因epsG包含与SEQ ID NO:95具有至少70％，如至少75％序列同一性的核苷酸序列。
根据一些实施方式，epsD基因包含与SEQ ID NO:92具有至少80％，如至少85％序列同一性的核苷酸序列，基因epsE包含与SEQ ID NO:93具有至少80％，如至少85％序列同一性的核苷酸序列，基因epsF包含与SEQ ID NO:94具有至少80％，如至少85％序列同一性的核苷酸序列，而基因epsG包含与SEQ ID NO:95具有至少80％，如至少85％序列同一性的核苷酸序列。
根据一些实施方式，epsD基因包含与SEQ ID NO:92具有至少90％，如至少95％序列同一性的核苷酸序列，基因epsE包含与SEQ ID NO:93具有至少90％，如至少95％序列同一性的核苷酸序列，基因epsF包含与SEQ ID NO:94具有至少90％，如至少95％序列同一性的核苷酸序列，而基因epsG包含与SEQ ID NO:95具有至少90％，如至少95％序列同一性的核苷酸序列。
根据一些实施方式，基因epsD编码包含与SEQ ID NO:42具有至少70％，如至少75％序列同一性的氨基酸序列的多肽，基因epsE编码包含与SEQ ID NO:43具有至少70％，如至少75％序列同一性的氨基酸序列的多肽，基因epsF编码包含与SEQ ID NO:44具有至少70％，如至少75％序列同一性的氨基酸序列的多肽，而基因epsG编码包含与SEQ ID NO:45具有至少70％，如至少75％序列同一性的氨基酸序列的多肽。
根据一些实施方式，基因epsD编码包含与SEQ ID NO:42具有至少80％，如至少85％序列同一性的氨基酸序列的多肽，基因epsE编码包含与SEQ ID NO:43具有至少80％，如至少85％序列同一性的氨基酸序列的多肽，基因epsF编码包含与SEQ ID NO:44具有至少80％，如至少85％序列同一性的氨基酸序列的多肽，而基因epsG编码包含与SEQ ID NO:45具有至少80％，如至少85％序列同一性的氨基酸序列的多肽。
根据一些实施方式，基因epsD编码包含与SEQ ID NO:42具有至少90％，如至少95％序列同一性的氨基酸序列的多肽，基因epsE编码包含与SEQ ID NO:43具有至少90％，如至少95％序列同一性的氨基酸序列，基因epsF编码包含与SEQ ID NO:44具有至少90％，如至少95％序列同一性的氨基酸序列的多肽，而基因epsG编码包含与SEQ ID NO:45具有至少90％，如至少95％序列同一性的氨基酸序列的多肽。
根据一些实施方式，基因epsD包含与SEQ ID NO:128具有至少70％，如至少75％序列同一性的核苷酸序列，基因epsE包含与SEQ ID NO:129具有至少70％，如至少75％序列同一性的核苷酸序列，基因epsF包含与SEQ ID NO:130具有至少70％，如至少75％序列同一性的核苷酸序列，而基因epsG包含与SEQ ID NO:131具有至少70％，如至少75％序列同一性的核苷酸序列。
根据一些实施方式，基因epsD包含与SEQ ID NO:128具有至少80％，如至少85％序列同一性的核苷酸序列，基因epsE包含与SEQ ID NO:129具有至少80％，如至少85％序列同一性的核苷酸序列，基因epsF包含与SEQ ID NO:130具有至少80％，如至少85％序列同一性的核苷酸序列，而基因epsG包含与SEQ ID NO:131具有至少80％，如至少85％序列同一性的核苷酸序列。
根据一些实施方式，基因epsD包含与SEQ ID NO:128具有至少90％，如至少95％序列同一性的核苷酸序列，基因epsE包含与SEQ ID NO:129具有至少90％，如至少95％序列同一性的核苷酸序列，基因epsF包含与SEQ ID NO:130具有至少90％，如至少95％序列同一性的核苷酸序列，而基因epsG包含与SEQ ID NO:131具有至少90％，如至少95％序列同一性的核苷酸序列。
根据一些实施方式，本发明的基因工程化的细菌修饰为使第一EPS基因簇失活。
根据一些实施方式，本发明的基因工程化的细菌(进一步)修饰为使第二EPS基因簇失活。
根据一些实施方式，本发明的基因工程化的细菌修饰为使第一EPS基因簇和第二EPS基因簇失活。
根据一些实施方式，第一EPS基因簇通过所述簇的部分或整个序列缺失而灭活。
根据一些实施方式，第一EPS基因簇通过所述簇的整个编码序列缺失而灭活。
根据一些实施方式，第一EPS基因簇通过所述簇的整个序列缺失而灭活。
根据一些实施方式，第一EPS基因簇通过启动子和/或核糖体结合位点区域的修饰(例如，通过引入至少一个突变)导致基因表达缺乏而被灭活。
根据一些实施方式，第二EPS基因簇通过所述簇的部分或整序列缺失而灭活。
根据一些实施方式，第二EPS基因簇通过所述簇的整个编码序列缺失而灭活。
根据一些实施方式，第二EPS基因簇通过所述簇的整个序列缺失而被灭活。
根据一些实施方式，第二EPS基因簇通过启动子和/或核糖体结合位点区域的修饰(例如，引入至少一个突变)导致基因表达缺乏而被灭活。
根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:181或183具有至少70％，如至少75％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:181或183具有至少80％，如至少85％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:181或183具有至少90％，如至少95％序列同一性的核苷酸序列。
根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:182或184具有至少70％，如至少75％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:182或184具有至少80％，如至少85％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:182或184具有至少90％，如至少95％序列同一性的核苷酸序列。
根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:181具有至少70％，如至少75％序列同一性的核苷酸序列，且缺失与SEQ ID NO:182具有至少70％，如至少75％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:181具有至少80％，如至少85％序列同一性的核苷酸序列，且缺失与SEQ ID NO:182具有至少80％，如至少85％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:181具有至少90％，如至少95％序列同一性的核苷酸序列，且缺失与SEQ ID NO:182具有至少90％，如至少95％序列同一性的核苷酸序列。
根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:183具有至少70％，如至少75％序列同一性的核苷酸序列，且缺失与SEQ ID NO:184具有至少70％，如至少75％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:183具有至少80％，如至少85％序列同一性的核苷酸序列，且缺失与SEQ ID NO:184具有至少80％，如至少85％序列同一性的核苷酸序列。根据一些实施方式，本发明的基因工程化的细菌修饰为缺失与SEQ ID NO:183具有至少90％，如至少95％序列同一性的核苷酸序列，且缺失与SEQ ID NO:184具有至少90％，如至少95％序列同一性的核苷酸序列。
根据一些实施方式，本发明的基因工程化的细菌修饰为缺失编码参与所述细菌中胞外多糖(EPS)生产的多肽的所有内源性基因。
根据本发明的细菌可以由任何合适的甲基菌属细菌生产。甲基菌属是革兰氏阴性甲基营养细菌属。
根据一些实施方式，本发明的细菌选自鞭毛甲基菌、糖原甲基菌、草原甲基菌(Methylobacillus pratensis)和根际甲基菌(Methylobacillus rhizosphaerae)。
根据一些实施方式，本发明的细菌选自鞭毛甲基菌和糖原甲基菌。
根据一些实施方式，本发明的细菌是鞭毛甲基菌。
根据一些实施方式，本发明的细菌是糖原甲基菌。
本发明的方法
本发明还提供了生产生物化学化合物的方法，包括在合适的培养条件下，在包含还原的单碳化合物如甲醇或不含碳-碳键的多碳化合物如二甲胺的培养基中培养本发明的细菌。
使用的培养基可以是适合培养所关注的细菌细胞的任何常规培养基，并且可以根据现有技术的原理进行构成。该培养基通常含有相应细菌生长和存活所需的所有营养物质，如碳源和氮源以及其他无机盐。合适的培养基，例如，最小或复杂的培养基可以从商业供应商处商购获得，或可以根据公开的配方制备，例如美国典型培养物保藏中心(ATCC)菌株目录(American Type Culture Collection(ATCC)Catalogue of strains)。本领域技术人员熟知的非限制性标准培养基包括Luria Bertani(LB)肉汤、Sabouraud Dextrose(SD)肉汤、MS肉汤、酵母蛋白胨-葡聚糖(Yeast Peptone Dextrose)、BMMY、GMMY或酵母麦芽提取物(Yeast Malt Extract)(YM)肉汤，这些都可以商购获得。用于培养细菌细胞如大肠杆菌细胞的合适培养基的非限制性实例，包括最小培养基和富培养基，如Luria肉汤(LB)、M9培养基、M17培养基、SA培养基、MOPS培养基、Terrific肉汤、YT等。
碳源可以是本领域已知的任何合适的碳底物，特别是通常用于甲基营养细菌培养和/或发酵的任何碳底物。特别感兴趣的碳源是还原的单碳化合物，如甲醇或甲胺，或不含碳-碳键的多碳化合物，如二甲胺。因此，根据一些实施方式，该培养基包含甲醇作为碳源。该培养基中甲醇的浓度通常可以为约0.5％w/v-约4％w/v，如约2％w/v-4％w/v。根据一些实施方式，该培养基中甲醇的浓度范围为约2.5％w/v-约3.5％w/v。
作为氮源，可以使用各种铵盐如氨和硫酸铵，其他氮化合物如胺类，天然氮源如蛋白胨、大豆水解物和消化的发酵微生物。作为矿物，可以使用单磷酸钾、硫酸镁、氯化钠、硫酸亚铁、硫酸锰、氯化钙等。
培养可以优选在有氧条件下进行，如通过摇动培养、通过搅拌培养或在具有曝气的生物反应器中，在约20-约45℃，如约30-38℃，优选约37℃的温度下进行。培养物的pH通常高于5，如约6-约8，优选约6.5-约7.5，更优选约6.8-约7.2的范围内。培养物的pH可以用氨、碳酸钙、各种酸、各种碱和缓冲液进行调节。该培养可以进行10-70小时，优选24-60小时，更优选36-50小时的时间段。
培养后，通过离心或膜过滤可以从培养基中去除如细胞的固体。生物化学化合物可以通过从培养基中分离和纯化化学化合物的常规方法收集。众所周知的纯化方案包括但不限于，离心或过滤、沉淀、离子交换、色谱法如离子交换色谱法或凝胶过滤色谱法，以及结晶方法。该方法可以还包括从培养基中收集生物化学化合物。
通过本发明的方法生产的生物化学化合物可以是通过培养本发明的细菌获得的任何所需化合物。非限制性实例包括有机酸、氨基酸、脂肪酸及其衍生物。有机酸的非限制性实例包括富马酸、乙醇酸、琥珀酸、苹果酸、丙二酸、乳酸及其衍生物。氨基酸的非限制性实例包括谷氨酸、赖氨酸、甲硫氨酸、色氨酸、苯丙氨酸及其衍生物。
因此，本发明提供了可以通过本文详述的方法获得的生物化学化合物。
某些其他定义
“多肽”和“蛋白质”在本文中可以互换使用，表示通过酰胺键共价连接的至少两个氨基酸的聚合物，无论其长度或翻译后修饰(如糖基化、磷酸化、脂化、肉豆蔻化、泛素化等)如何。该定义包括D-和L-氨基酸，以及D-和L-氨基的混合物。
“核酸”或“多核苷酸”在本文中可以互换使用，而表示通过磷酸二酯键共价连接的至少两个核酸单体单元或碱基(例如，腺嘌呤、胞嘧啶、鸟嘌呤、胸腺嘧啶)的聚合物，而无论其长度或碱基修饰。
当涉及例如宿主细胞、核酸或多肽使用时，“重组”或“非天然的”是指一种材料，或与该材料的自然或天然形式相对应的材料，以自然界中不存在的方式进行了修饰，或与之相同，但由合成材料和/或通过使用重组技术的操纵而产生或进行衍生化。非限制性实例包括例如表达细胞天然(非重组)形式中未发现的基因或表达以不同水平以其他方式表达的天然基因的重组细菌细胞。
本文在基因或核酸分子上下文中使用的“异源”或“外源”是指不作为其存在于其中的细菌基因组的一部分天然出现的基因或核酸(即DNA或RNA分子)，或在基因组中存在或发现于与其在自然界中不同的位置或位点上的基因或核酸分子。因此，“异源”或“外源”基因或核酸分子不是细菌内源性的，而是外源性引入微生物的。“异源”基因或核酸分子DNA分子可能来自不同生物体、不同物种、不同属或不同生物界，作为宿主DNA。
本文在多肽上下文中使用的“异源”是指多肽通常在宿主微生物中并未发现或并非由宿主微生物制造(即，表达)，而是来源于不同生物体、不同物种、不同属或不同生物界。
如本文所用，术语“直系同源物”或“直系物”是指衍生自共同祖先基因而却存在于不同物种中的基因、由此编码的核酸分子(即，mRNA)或由此编码的蛋白质。
基因的“降低的表达”是指与不携带所述修饰的其他相同的细菌相比，由经过修饰的细菌产生的所述基因编码的转录产物的量，相应地多肽(例如酶)的量减少。更具体地，对于基因的“降低的表达”，是指由经过修饰的细菌产生的基因编码的多肽(例如酶)的量，相应地转录产物的量，与不携带所述修饰的其他相同的细菌相比降低了至少10％，如至少20％，至少30％，至少40％，至少50％，至少60％，至少70％，至少80％，至少90％或至少100％。基因的表达水平可以通过众所周知的方法确定，包括PCR、Southern蛋白印迹法等。此外，通过使用各种众所周知的方法(包括Northern蛋白印迹法、定量RT-PCR法等)测量可以从基因转录的mRNA量而估算基因表达水平。该基因编码的多肽量可以通过众所周知的方法，包括ELISA、免疫组织化学法或Western蛋白印迹法等。
通过将突变引入细菌基因组中的基因中可以降低基因的表达，从而与不携带所述突变的其他相同的细菌相比，由该基因编码的多肽的细胞内活性降低。导致基因表达降低的突变包括一个或多个核苷酸的替换而引起由基因编码的多肽中的氨基酸替换(错义突变)、终止密码子的引入(无义突变)、核苷酸缺失或插入而引起框移、抗药性基因插入，或部分或整基因缺失(Qiu and Goodman，1997；Kwon et al，2000)。表达也可以通过修饰表达调节序列如启动子、Shine-Dalgarno(SD)序列等而降低。基因的表达也可以由基因替代而降低(Datsenko and Wanner，2000)，如“λ红介导的基因替代”。λ红介导的基因替代是使本文所述的一个或多个基因灭活的特别合适的方法。
“灭活(inactivating)”、“灭活(inactivation)”和“灭活的(inactivated)”，当用于基因或基因簇时，是指所讨论的基因或基因簇不再表达功能蛋白。由于基因或基因簇的部分或全序列缺失、基因或基因簇的阅读框移位、错义/无义突变引入或基因或基因簇调控区修饰，所修饰的DNA区域有可能不能自然表达该基因或基因簇，包括控制基因表达的序列，如启动子、增强子、减毒子、核糖体结合位点等。优选通过基因或基因簇的部分或整序列缺失，如通过基因替代，使所关注的基因或基因簇灭活。灭活也可以通过引入或表达可以通过DNA切割，优选通过双链断裂，选择性灭活所关注的基因或基因簇的稀切核酸内切酶实现。本发明上下文中的“稀切核酸内切酶”包括转录激活子样效应器(TALE)核酸酶、巨核酸酶、锌指核酸酶(ZFN)和RNA-引导核酸内切酶。
细菌基因组中基因或基因簇的存在或不存在可以通过众所周知的方法检测，包括PCR、Southern蛋白印迹法等。此外，通过使用各种众所周知的方法，包括Northern蛋白印迹法、定量RT-PCR等，测量从该基因或基因簇转录的mRNA量而估算基因表达水平。基因或基因簇编码的多肽的量可以通过众所周知的方法进行测量，包括SDS-PAGE，然后进行免疫印迹分析测试(Western蛋白印迹分析)等。
如本文所用，多肽(如本文所述的酶)表达的“减少(decreased)”、“降低(decreasing)”或“减小(decrease of)”是指与所述多肽在不携带所述修饰的其他相同的细菌(对照)中的表达相比，所述多肽的表达在该经过修饰的细菌中降低。与多肽在不携带所述修饰的其他相同的细菌(对照)中的表达相比，该多肽在该经修饰的细菌中的表达可以降低至少约10％，而优选至少约20％、至少约25％、至少约30％、至少约35％、至少约40％、至少约45％、至少约50％、至少约55％、至少约60％、至少约65％、至少约70％、至少约75％、至少约80％、至少约85％，至少约90％、至少约95％、至少约99％或100％，或10％-100％之间的任何全整数百分比(例如，6％、7％、8％等)。更具体地，与不携带所述修饰的其他相同的细菌(对照)中的该多肽的量相比，多肽表达的“降低”、“减小”或“减少”是指所经修饰的细菌中多肽的量降低至少约10％，而优选至少约20％、至少约30％、至少约35％、至少约40％、至少约45％、至少约50％、至少约55％、至少约60％、至少约65％、至少约70％、至少约75％、至少约80％、至少约85％、至少约90％、至少约95％、至少约99％或100％，或10％-100％之间的任何全整数百分比(例如6％、7％、8％等)。多肽在细菌中的表达或量可以通过本领域已知的任何合适的手段进行测定，包括诸如ELISA、免疫组织化学法、Western蛋白印迹法或流式细胞术等技术。
如本文所用，多肽(如本文所述的酶)的表达“消除”是指与所述多肽在不携带所述修饰的其他相同的细菌(对照)中的表达相比，所述多肽的表达在该经修饰的细菌中是不可检测的。
如本文所用，多肽(如本文所述的酶)活性的“降低”、“减小”或“减弱”是指与所述多肽在不携带所述修饰的其他相同的细菌(对照)中的催化活性相比，该多肽的催化活性在该经修饰的细菌中降低。与该多肽在不携带所述修饰的其他相同的细菌(对照)中的表达相比，该多肽在经修饰的细菌中的活性可以降低至少约10％，而优选至少约20％、至少约25％、至少约30％、至少约35％、至少约40％、至少约45％、至少约50％、至少约55％、至少约60％、至少约65％、至少约70％、至少约75％、至少约80％、至少约85％、至少约90％、至少约95％、至少约99％或100％，或10％-100％之间的任何全整数百分比(例如，6％、7％、8％等)。多肽在细菌中的活性可以通过任何合适的蛋白质和酶活性分析测试法进行测定。
“表达”包括参与多肽(如，编码的酶)生产的任何步骤，包括但不限于转录、转录后修饰、翻译、翻译后修饰和分泌。
如本文所用，基因或基因簇的“调控区”是指影响编码序列进行表达的核酸序列。调节区在本领域内是已知的，包括但不限于启动子、增强子、转录终止子、多腺苷酸化位点、基质附着区和/或调节编码序列表达的其他元件。
“取代”或“取代的”是指通过用另一个氨基酸残基取代一个氨基酸残基而修饰所述多肽，例如，多肽序列中的丝氨酸残基被甘氨酸或丙氨酸残基取代就是一种氨基酸取代。当涉及多核苷酸进行使用时，“取代”或“取代的”是指通过用另一个核苷酸取代一个核苷酸而修饰该多核苷酸，例如，在多核苷酸序列中用胸腺嘧啶取代胞嘧啶就是核苷酸取代。
当涉及多肽进行使用时，“保守取代”是指用具有相似侧链的不同残基取代一个氨基酸残基，而因此通常涉及用相同或相似类别氨基酸中的氨基酸取代多肽中的氨基酸。作为示例而非限制，具有脂族侧链的氨基酸可以被另一种脂族氨基酸取代，例如丙氨酸、缬氨酸、亮氨酸和异亮氨酸；具有羟基侧链的氨基酸被另一个具有羟基侧链路的氨基酸取代，例如丝氨酸和苏氨酸；具有芳族侧链的氨基酸被另一具有芳族侧链的氨基酸取代，例如苯丙氨酸、酪氨酸、色氨酸和组氨酸；具有碱性侧链的氨基酸被另一个具有碱性侧链的氨基酸取代，例如赖氨酸和精氨酸；具有酸性侧链的氨基酸被另一个具有酸性侧链的氨基酸取代，例如天冬氨酸或谷氨酸；和疏水性或亲水性氨基酸分别被另一个疏水性或亲水性氨基酸取代。
当涉及多肽使用时，“非保守取代”是指用侧链性质显著不同的氨基酸取代多肽中的氨基酸。非保守取代可以使用定义的组之间而不是之内的氨基酸，并影响(a)取代区域中肽骨架的结构(例如，丝氨酸取代甘氨酸)，(b)电荷或疏水性，或(c)侧链的主体(bulk)。作为示例而非限制，示例性非保守取代可以是碱性或脂族氨基酸取代酸性氨基酸；小氨基酸取代芳族氨基酸；和疏水性氨基酸取代亲水性氨基酸。
如本文所用，“载体”是指可以运输与其连接的另一核酸分子的核酸分子。一种类型的载体是“质粒”，它是指一种其他核酸片段可以连接到其中的环状双链核酸环。某些载体可以指导与其操作性连接的基因的表达。这种载体在本文中被称为“表达载体”。某些其他载体可以促进外源核酸分子插入细菌基因组。这种载体在本文中被称为“变形载体”。通常，在重组核酸技术中有用的载体通常是以质粒的形式。在本说明书中，“质粒”和“载体”可以互换使用，因为质粒是最常用的载体形式。大量合适的载体对于本领域技术人员是已知的，并且可以商购获得。
如本文所用，“启动子”是指DNA序列，通常位于结构基因编码区的上游(5')，通过为RNA聚合酶和转录起始所需的其他因子提供识别和结合位点而控制编码区的表达。启动子的选择将取决于所关注的核酸序列。合适的“启动子”通常是可以支撑本发明细菌中转录的启动，从而产生mRNA分子的启动子。
如本文所用，“可操作地连接”是指一种并置，其中描述的组分处于允许它们以其预期方式发挥功能的关系中。与编码序列“可操作地连接”的控制序列以此方式连接而使编码序列在与控制序列相容的条件下实现表达。当启动子序列足够接近基因的转录起始位点而调节基因转录时，启动子序列就与该基因“可操作地连接”。
“序列同一性百分比”、“％序列同一性”和“％同一性”是指核苷酸序列与参考核苷酸序列之间或氨基酸序列与参考氨基酸序列之间的序列同一性。序列同一性可以通过比较每个序列中的位置而确定，这可以为了比较目的而进行比对。当所比较的序列中的一个位置被相同的碱基或氨基酸占据时，则该分子在该位置是相同的。核苷酸或氨基酸序列之间的相同程度是在核苷酸或氨基酸序列共享位置上相同或匹配的核苷酸或氨基酸的数量的函数。使用各种比对算法和/或程序就可以计算出两个序列之间的同一性，包括FASTA或BLAST，其作为GCG序列分析软件包(University of Wisconsin,Madison,Wis.)的一部分可获得，并且可以采用默认设置进行使用。
如本文所用，术语“约”是指所使用的数字的数值的±10％。
如果本文规定了数值限制或范围，则包括端点。此外，数值限制或范围内的所有值和子范围都明确地包括在内，就像明确地写出一样。
如本文所用，不定冠词“一个”和“一种”是指“至少一个”或“一个或多个”，除非上下文另有明确规定。
如本文所用，术语“包含”、“包括”、“具有”及其语法变体都应该视为指定所述特征、步骤或组件，而非排除一个或多个其他特征、步骤、组件或组群的添加。
在概括描述了本发明之后，通过参考某些具体实例可以获得进一步的理解，这些实例在本文中仅出于举例说明的目的而提供，并且除非另有规定，否则并非旨在限制。
实施例
实施例1：鞭毛甲基菌和糖原甲基菌中EPS生产基因的确定
基于生物信息学分析，选择了几个基因组基因座进行破坏。先前已经公开了鞭毛甲基菌中两个EPS相关基因簇的遗传位置(Chistoserdova etal.，2007)。为了标注出第一甲基菌EPS生产基因簇(SEQ ID NO:87-112)中的基因，通过NCBI BLAST蛋白质搜索，使用Python编程语言中的自定义脚本，将来自公开的甲基菌12S甲醇烷(methanolan)合成簇(Yoshida et al.，2000)的基因同源物与鞭毛甲基菌基因组进行比较。根据由E值、检索覆盖率和序列同一性组成的计算组合得分，选择出最佳选择(top hit)。然后在基因组序列中手动定位每个基因的单个最佳选择并进行注释。这些最佳选择的位置与所发表的第一簇的位置一致。由于没有为每个基因找到明确的同源物，则因此最远同源物之间的所有基因都被认为是该簇的部分。大多数这样的未注释基因都编码糖和多糖相关基因。使用相同的方案确定出糖原甲基菌中完全未注释的EPS簇(SEQ ID NO:125-146)。
在鞭毛甲基菌的基因组序列(SEQ ID NO:113-124)中预测第二EPS相关簇。进行BLAST搜索，将这些基因与甲醇烷簇进行比较，没有发现明确的同源物。通过针对所有非冗余蛋白质序列的NCBI蛋白质BLAST搜索，确定出该簇中每个单独基因的蛋白质产物，并且如上所述选择出每个基因的最佳选择。使用NCBI蛋白质BLAST在糖原甲基菌基因组中交叉搜索来自该甲基菌蛋白质簇的每个基因的蛋白质序列。找出最佳选择而在糖原甲基菌中构成类似簇(SEQ ID NO:147-172)。
在每个EPS-相关基因簇中的所确定的开放阅读框(ORF)显示于下表1-4中。
表1：鞭毛甲基菌中EPS基因簇1的ORF
表2：鞭毛甲基菌EPS基因簇2的ORF
表3：糖原甲基菌中EPS基因簇2的ORF
表4：糖原甲基菌中EPS基因簇2的ORF
表5：各簇的全序列
SEQ ID NO 生物体 簇 链
173 鞭毛甲基菌 1 顶
174 鞭毛甲基菌 1 底
175 鞭毛甲基菌 2 顶
176 鞭毛甲基菌 2 底
177 糖原甲基菌 1 顶
178 糖原甲基菌 1 底
179 糖原甲基菌 2 顶
180 糖原甲基菌 2 底
基于与甲基菌属菌株12中EPS生产必需基因的相似性，选择出注释为epsD、epsE、epsF和epsG的ORF(鞭毛甲基菌中的SEQ ID NO:6-9，糖原甲基菌中SEQ ID NO:42-45)进行缺失(Yoshida et al，2003)。由于第二EPS簇在其他表征的EPS簇中没有明确同源物，因此选择鞭毛甲基菌中的所有12个ORF(SEQ ID NO:27-38)和糖原甲基菌中的所有26个ORF(SEQID NO:61-86)进行缺失。
实施例2：DNA缺失
制备出的ABME5和ABME6的修饰菌株中缺失了任一个EPS生产簇或两个EPS生产簇。基因组编辑通过引入线性DNA片段实现，该DNA片段由卡那霉素或利福平抗性盒组成，其两侧是整合位点上游和下游的2kb长序列。通过电穿孔将DNA片段转化至ABME5和ABMR6中。转化结果接种到含有20g/L琼脂、50μg/mL卡那霉素或5μg/mL利福平的选择性PM7孔板上长达24-48小时。将ABME 5-衍生菌株在30℃下培养。ABME 6-衍生菌株在37℃下培养。通过菌落PCR确认克隆正确。表6列出了通过DNA缺失制备的菌株。
表6：利用基因组整合制备的菌株列表
实施例3：鞭毛甲基菌EPS基因破坏前后摇瓶培养物中的总EPS的测量
为了评价ABME6中EPS生产基因缺失的效果，如实施例3所述制备三种修饰的ABME6菌株(ABME80、ABME82和ABME131)，并测试EPS生产。
将确认的转化体在PM7+50μg/mL卡那霉素琼脂孔板上生长过夜。将单个菌落再悬浮于250mL带挡板摇瓶中的25mL PM7培养基+25μg/mL卡那霉素中，并在200rpm下培养过夜。第二天，用2.5mL过夜培养物接种250mL带挡板摇瓶中的50mL PM7培养基+25μg/mL卡那霉素。所有ABME 5衍生菌株在30℃下培养，所有ABME 6衍生菌株在37℃下培育。然后将培养物在冰上冷却，将试样等分于2mL Eppendorf管中，并在4℃标准台式离心机上以15000rpm离心15分钟。当细胞沉淀上方可见一层EPS时，将其混合回上清液中。将培养物上清液储存以用于EPS水解。通过加入一半体积的6M TFA(三氟乙酸)上清液进行水解，得到3M最终TFA浓度。各根管置入加热至120℃的热块中，培养6h。水解后，液体(包括TFA)在80℃下蒸发，直至完全干燥。干物质再悬浮于0.5M NaOH(体积与原始培养物等分试样相同)中，并在HPLC上分析单体糖。
表7：用于摇瓶实验的PM7培养基的组成
ABME 6离心后在细胞颗粒顶部产生可见的黏液层，水解后总单体糖为约1g/L。单簇破坏(ABME 80和ABME 82)没有可见的黏液层，但仍产生约500mg/L总糖。感兴趣的是，取决于哪个基因簇被破坏，葡萄糖与总糖的比例是颠倒的，这很可能是由于产生了两种不同类型的EPS。当两个簇都被破坏时(菌株ABME 131)，糖低于检测限。
实施例4：EPS基因破坏前后鞭毛甲基菌反应器培养物中的粘度测量
为了评价EPS生产破坏前后发酵液粘度的变化，比较了氧气限制之下的5升生物反应器发酵菌株。生物反应器接种培养物总是按如下方式制备。将250mL带挡板摇瓶中的25mLPM7培养基用250μL菌株冷冻原液接种，原液OD调整为5，以产生0.05的起始OD。将培养物在37℃下以200rpm培养过夜。早上，将2L带挡板摇瓶中的200mL PM7培养基接种10％(20mL)过夜培养物，并生长直至OD～1(+/-0.2)。然后使用该培养物在5L生物反应器中接种2.5L起始体积的无菌PM3培养基(8％接种物)。通过自动添加NH4OH将pH保持于7，并将温度保持于37℃。
对于氧限制过程，甲醇自动进料以保持浓度于3-6g/L。反应器曝气和搅拌保持最大，但在此过程期间氧气浓度总降至0％。肉汤定期取样进行OD、矿物质和代谢产物测量。在过程结束时测量粘度，结果汇总于图2中。野生型鞭毛甲基菌发酵液取样时具有400厘泊高粘度。还测量了不同种类的甲基菌ABME 145，并产生了422厘泊的类似粘度的肉汤。双簇破坏产生了明显粘度较低的肉汤，其可以使用标准台式设备进行离心和过滤，这在以前的样品中是不可能的。粘度计证实了这个评价，测量到35cP粘度或粘度降低近10倍。还测量了大肠杆菌发酵液的代表性样品以进行比较。
实施例5：鞭毛甲基菌中EPS基因消除前后摇瓶中起泡减少的测量
我们观察到，EPS缺乏的菌株显示出起泡明显较少。为了比较ABME 6相对于EPS缺乏突变菌株(ABME 82和ABME 131)的泡沫形成，如实施例3所述培养各菌株。
为了测量泡沫形成，将摇瓶从振荡器上取下，并使液体沉降5分钟。用卷尺测量液体顶部的泡沫层(图3)。野生型培养物在液体顶部产生0.5-1cm的泡沫层，而单簇破坏仅在液体弯月面处积累约1mm泡沫。在双簇破坏培养物中完全看不到泡沫。
实施例6：鞭毛甲基菌中EPS基因破坏前后生物反应器培养中起泡减少的测量
为了评价EPS生产破坏前后发酵液起泡的变化，在5L生物反应器发酵中对各菌株进行了比较。泡沫形成量近似于添加消泡剂的量(SAG 5693)。发酵在限碳条件下进行。
如实施例5中所述对反应器进行接种。为了实现限碳，将50％甲醇以在最高曝气和搅拌设置下将pO2值保持于约30％的动态计算速率自动加入反应器。添加的甲醇立即消耗并保持于检测水平以下。当泡沫到达放置于发酵液弯液面上方的检测器时，自动添加消泡剂。以这种方式测试ABME 6和ABME 131。在ABME 131的情况下，5小时后开始添加消泡剂。ABME 131发酵中添加的消泡剂减少了约60％，具体取决于发酵时间(图4)。
实施例7：EPS基因破坏前后鞭毛甲基菌细胞聚结体的显微镜图像
为了评价EPS生产破坏前后细胞聚集起泡的变化，如实施例3所述，在限氧下5L生物反应器发酵中培养各菌株。
通过Zeiss Axioplan 2显微镜上的相位对比显微，凭借Zeiss Ph2 PlanNEOFLUAR 40x物镜(NA 0.75)观察肉汤样品，并在sCMOS相机上记录。ABME 6细胞形成大团块，并固定于EPS基质中(图5)。在双簇破坏菌株ABME 131的情况下，细胞各自漂浮于溶液中，聚结程度极低。
实施例8：无EPS的鞭毛甲基菌的甲醇耐受性改善
高甲醇浓度耐受性是高效生物过程的关键参数。为了证实不能生产EPS的菌株的甲醇耐受性没有降低，在ABME 6及其产EPS衍生菌株ABME 131中测试了甲醇浓度增加时的生长。
如实施例4中所述，在摇瓶中测试各菌株。为了测试甲醇耐受性，将初始甲醇浓度提高到4.5％。24小时后测定OD600。
出乎意料的是，与ABME 6相比，ABME 131的甲醇耐受性更高。例如，在2.75％的初始甲醇浓度下，无EPS的ABME 131生长到1.6的OD600，而野生型ABME 6仅生长到0.3的OD600。2.75％下的生长差异最显著。然而，与ABME 6相比，ABME 131的生长改善在所有甲醇浓度下都是明显的(图6)。
说明书中引述的参考文献列表
Chistoserdova,L.et al.(2007)‘Genome of Methylobacillus flagellatus,Molecular Basis for Obligate Methylotrophy,and Polyphyletic Origin ofMethylotrophy’,Journal of Bacteriology.American Society for MicrobiologyJournals,189(11):4020–4027.
Hattori,M.et al.(2020)Methylobacillus glycogenes JCM 2850,wholegenome shotgun sequencing p-Nucleotide-NCBI.
Yoshida,T.et al.(2000)‘Saccharide production from methanol bytransposon 5mutants derived from the extracellular polysaccharide-producingbacterium Methylobacillus sp.strain 12S’,Applied Microbiology andBiotechnology.doi:10.1007/s002530000407.
Yoshida,T.et al.(2003)‘Genes involved in the synthesis of theexopolysaccharide methanolan by the obligate methylotroph Methylobacillussp.strain 12S’,Microbiology.Microbiology Society,pp.431–444.doi:10.1099/mic.0.25913-0.
Qui Z and Goodman MF:The Escherichia coli polB locus is identical todinA,the structural gene for DNA polymerase II.Characterization of Pol IIpurified from a polB mutant.J Biol Chem.1997,272(13):8611-8617.
Kwon DH,JA,Osato MS,Fox JG,Graham DY,Versalovic J:Frameshiftmutations in rdxA and metronidazole resistance in North American Helicobacterpylori isolates.J Antimicrob Chemother 2000,46(5):793-796
Datsenko KA,Wanner BL:One-step inactivation of chromosomal genes inEscherichia coli K-12using PCR products.Proc Natl Acad Sci U S A 2000,97:6640-6645。
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Gly Asp Gln Ser Arg Gly Leu Gln Ala His Lys Pro Glu Thr Cys Tyr
100 105 110
Thr Ala Gln Gly Phe Asn Val Asp Leu Leu Gly Asn Ala Ile Leu Asn
115 120 125
Phe Asp Gly Tyr Glu Ile Lys Val Arg His Leu Leu Ala Gln His Gly
130 135 140
Ala Arg Tyr Glu Pro Ile Leu Tyr Trp Met Arg Val Gly Glu Thr Thr
145 150 155 160
Val Tyr Gly Gly Leu Gly Gln Thr Ile Lys Arg Phe Glu Leu Gly Leu
165 170 175
Gln Gly Tyr Ile Pro Asp Gly Leu Leu Phe Arg Val Ser Ser Ile Ser
180 185 190
Arg Asp Asn Ile Ser Ala Phe Thr Leu Gln Glu Glu Phe Val Lys Ser
195 200 205
Leu Leu Lys Asn Val Asp Ser Lys Ser Arg Lys Lys Leu Ile Gly Thr
210 215 220
Phe Ser
225
<210> 12
<211> 428
<212> PRT
<213> 鞭毛甲基菌
<400> 12
Met Ile Lys His Thr Ala Phe Met Ala Leu Ser Thr Phe Ser Arg Leu
1 5 10 15
Leu Ser Ala Val Val Leu Phe Ile Ile Leu Ala Arg Phe Leu Gly Pro
20 25 30
Arg Asp Phe Gly Ile Leu Met Tyr Asn Phe Thr Leu Ala Ser Ile Ala
35 40 45
Val Leu Leu Val Glu Tyr Gly Phe Ser Asn Gln Leu Leu Arg Asp Ile
50 55 60
Gly Arg Tyr Pro Asp Asn Ile Asn Gln Leu Met Gly Arg Val Phe Leu
65 70 75 80
Ala Lys Leu Tyr Leu Thr Val Val Met Gly Val Cys Cys Leu Ala Gly
85 90 95
His Tyr Leu Phe Tyr Thr Asn Asp Leu Asp Arg Ala Ile Phe Trp Ile
100 105 110
Leu Leu Leu Ser Cys Leu Leu Thr Ser Phe Gly Asp Phe Phe Asn Ile
115 120 125
Ala Phe Arg Gly Ile Gly Lys Phe His Glu Glu Thr Lys Val Ala Thr
130 135 140
Ile Gly Ser Leu Leu His Phe Gly Leu Ile Val Leu Met Val Ile Asn
145 150 155 160
Gly Ala Glu Leu Leu Leu Ile Ser Leu Gly Phe Val Leu Ser Arg Phe
165 170 175
Val Tyr Phe Ile Leu Ser Trp Arg Ala Tyr Lys Arg Val Val Gly Asp
180 185 190
Leu Asn Thr Leu Ser Ala Ser Pro Val Ala Val Leu Lys Ala Leu Lys
195 200 205
Ala Gly Phe Pro Tyr Ala Val Asp Ala Gly Phe Thr Asn Phe Phe Tyr
210 215 220
Gln Val Asp Thr Met Leu Val Lys Tyr Tyr Leu Gly Ala Thr Gly Val
225 230 235 240
Gly Ile Tyr Gln Ala Gly Met Arg Phe Leu Asn Gly Ala Met Gln Phe
245 250 255
Ala Pro Val Leu Gly Asn Val Phe Leu Pro Val Ile Ala Ala Lys His
260 265 270
Thr Asn Thr Arg Glu Phe Val Glu Leu Ala Lys Lys Leu Asn Leu Gln
275 280 285
Met Leu Ala Val Gly Thr Val Cys Trp Ala Ile Phe Trp Phe Ala Gly
290 295 300
Met His Ile Thr Glu Phe Val Phe Gly Asp Glu Tyr Val Glu Leu Asn
305 310 315 320
Ser Ile Trp Pro Tyr Ile Gly Leu Leu Val Phe Thr Arg Tyr Leu Ala
325 330 335
Ala Pro Gln Gly Val Leu Leu Thr Ala Ser Gly Ser Gln Thr Ile Arg
340 345 350
Val Trp Ala Gln Ile Phe Ala Leu Ile Ile Leu Leu Ile Ser Ala Pro
355 360 365
Leu Leu Met Lys Val Ile Gly Leu Lys Gly Met Val Ile Ala Leu Ile
370 375 380
Ile Thr Leu Leu Thr Leu Phe Leu Ile Phe Phe Ser Ala Leu Arg Leu
385 390 395 400
Arg Lys Ile Pro Thr Gly Phe Gly Gly Val Asn Phe Thr Leu Thr Val
405 410 415
Ile Val Phe Ser Leu Ser Ile Phe Leu Leu Val Tyr
420 425
<210> 13
<211> 392
<212> PRT
<213> 鞭毛甲基菌
<400> 13
Met Leu Lys Ile Gly Leu Leu Trp His Ser Thr Thr Ser Asp Asn Leu
1 5 10 15
Gly Val Gly Ala Leu Thr Glu Ala Gln Ile Ser Ile Ile Asn Lys Ala
20 25 30
Ala Val Gln Ala Gly Val Glu Val Glu Tyr Arg Ile Phe Gly Thr Asn
35 40 45
Gly Asn Lys Asp Tyr Phe Glu Gly Asn Pro Leu Ile Glu Arg Gly Thr
50 55 60
Asn Val Ser Leu Lys Arg Ile Leu Ile Gly Ala Ser Asp Tyr Pro Lys
65 70 75 80
Lys Ile Arg Glu Cys Asp Val Val Phe Asp Ile Gly Glu Gly Asp Ser
85 90 95
Phe Ala Asp Ile Tyr Gly Phe Ser Arg Phe Leu Ile Gln Ile Val Ser
100 105 110
Lys Leu Val Val Leu Phe Gln Arg Lys Pro Leu Ile Leu Ser Pro Gln
115 120 125
Thr Ile Gly Pro Phe Glu Ser Arg Phe Asn Leu Lys Val Ala Asn Asn
130 135 140
Val Met Gln Arg Cys Thr Lys Ile Phe Val Arg Asp Gly Leu Ser Phe
145 150 155 160
Gly Tyr Leu Gln Lys Asn Asn Leu Ser Val Asn Ala Glu Glu Val Ile
165 170 175
Asp Val Ala Phe Arg Leu Pro Phe Gln Arg Pro Ser Arg Asp Ser Ser
180 185 190
Lys Val Lys Ile Gly Leu Asn Val Ser Gly Leu Leu Tyr Asn Gly Gly
195 200 205
Tyr Thr Gly Lys Asn Gln Phe Gly Leu Ser Val Asn Tyr Pro Glu Leu
210 215 220
Thr Arg Ser Leu Leu Asp Gln Phe Thr Arg Ile Glu Gly Cys Glu Val
225 230 235 240
Trp Leu Val Pro His Val Leu Thr Thr Ser Phe Pro Ile Glu Asp Asp
245 250 255
Val Asn Val Cys Val Gln Leu Gln Glu Leu Tyr Pro Ala Ala Lys Leu
260 265 270
Ala Pro Ser Phe Ser Ser Pro Ser Gln Ala Lys Ser Phe Ile Ser Gly
275 280 285
Met Asp Phe Phe Leu Gly Ala Arg Met His Ala Cys Ile Ala Ala Phe
290 295 300
Ser Ser Gly Val Pro Val Val Pro Leu Ala Tyr Ser Arg Lys Phe Asn
305 310 315 320
Gly Leu Phe Ser Ala Leu Asp Tyr Pro Tyr Leu Gly Asp Cys Lys Val
325 330 335
Asn Thr Asn Glu Gln Ile Val Gly Leu Val Met Asp Cys Phe Asn Ser
340 345 350
Arg Glu Gln Leu Lys Phe Ala Val Glu Glu Gly Asn Lys Ile Ala Glu
355 360 365
Lys Lys Leu Leu Arg Tyr Glu Gln Tyr Ile Ala Glu Leu Leu Thr Arg
370 375 380
Ile Ser Asn Lys Lys Ile Val Leu
385 390
<210> 14
<211> 340
<212> PRT
<213> 鞭毛甲基菌
<400> 14
Met Tyr Ser Cys Lys Met Lys Lys Tyr Ile Ile Gly Phe Leu Pro Leu
1 5 10 15
Ser Ile Lys Trp Leu Leu Arg Phe Cys Leu Arg Gly Pro Ser Leu Leu
20 25 30
Arg Asp Phe Cys Tyr Asp Ala Lys Arg Tyr Ile Lys Trp Ser Ser Val
35 40 45
Ile Ser Phe Glu Lys Asp Arg Glu Lys Ile Leu Ala Val Ile Thr Ala
50 55 60
Thr Tyr His Asn Ile Glu Lys Gly Met Ser Leu Pro Asn Pro Arg Pro
65 70 75 80
Leu Phe Gly Arg Val Val Ile Gly Gln Leu Val Gly Ser Val Asp Asn
85 90 95
Phe His Leu Asn Phe Gly Pro Asp Pro Gln Leu Asp Val Pro Ile Asn
100 105 110
Val Leu Ala Arg Tyr Cys Gln Phe Asn Arg Ser Leu Gly Gln Pro Asp
115 120 125
Ser Gln Leu Glu Val Ile Val Asp Arg Leu Lys Lys Asn Asn Gln Ser
130 135 140
Thr Leu Leu Arg Ile Asn Asp Gly Gly Val Ile Leu Arg Ser Lys Ala
145 150 155 160
Glu Val Leu Asp Ala Ile Ser Gly Val Lys Glu Asp Phe Phe Leu Met
165 170 175
Arg His Ser Val Arg Gln Phe Thr Lys Asp Pro Ile Glu His Ser Val
180 185 190
Ile Glu Lys Ala Val Arg Ile Ala Gln Lys Ser Pro Ala Val Cys Asn
195 200 205
Arg Gln Ser Gly Lys Val Arg Ala Ile Leu Asn Pro Glu Leu Ile Arg
210 215 220
Ser Thr Leu Gln Ile Gln Gly Gly Ala Arg Gly Phe Tyr Glu Glu Val
225 230 235 240
Gln Ala Leu Phe Cys Ile Thr Val Asp Leu Ser Asn Phe Asn Gly Ala
245 250 255
Glu Arg Tyr Gln Gly Trp Ile Asp Gly Gly Met Phe Ala Met Ser Phe
260 265 270
Ile Tyr Gly Leu His Leu Gln Gly Leu Gly Ser Cys Ala Leu Asn Trp
275 280 285
Ser Lys Thr Arg Lys Gln Asp Ile Glu Met Arg Asn His Leu Arg Ile
290 295 300
Pro Glu Asn Glu Leu Ile Ile Met Phe Val Ala Ala Gly Tyr Leu Arg
305 310 315 320
Glu Ser Phe Val Val Pro Gln Ser Tyr Arg Lys Pro Leu Gly Glu Val
325 330 335
Leu Ser Tyr Ile
340
<210> 15
<211> 490
<212> PRT
<213> 鞭毛甲基菌
<400> 15
Met Lys Asn Asn Ser Ser Leu Leu Ser Phe Asn Arg Arg Asp Ala Asn
1 5 10 15
Phe Val Ser Leu Lys Ile Gly Ser Ile Phe Phe Val Ile Met Ala Ala
20 25 30
Ile Val Ala Leu Ile Phe Gly Phe Val Ser Ala Ile Phe Pro Trp Trp
35 40 45
Trp Ile Val Ala Ile Ile Leu Ser Ile Leu Phe Ile Phe Ile Gly Phe
50 55 60
Thr Tyr Pro Leu Val Ala Leu Ile Ala Val Ile Ala Ile Ser Ser Arg
65 70 75 80
Leu Ile Pro Asp Thr Phe Leu Pro Ser Ile Arg Leu Leu Gly Gly Thr
85 90 95
Ile Pro Ser Ser Asp Met Ala Leu Phe Ala Thr Phe Ile Phe Cys Phe
100 105 110
Phe Lys Tyr Asn Ser Glu Phe Ser Phe Thr Lys Gln Ala Leu Ser Pro
115 120 125
Leu Ala Ile Pro Leu Phe Val Val Leu Leu Leu Leu Leu Phe Ser Val
130 135 140
Phe Arg Ala Val Phe Glu Ile Arg Leu Pro Leu Lys Asp Ile Leu Gly
145 150 155 160
Glu Ser Arg His Phe Leu Tyr Trp Leu Leu Ile Pro Leu Ile Ala Leu
165 170 175
Thr Cys Ser Asp Arg Gln Arg Phe Lys Phe Ile Val Phe Gly Phe Leu
180 185 190
Phe Val Ala Phe Leu Phe Ser Ile Gly Gln Ile Leu Gln Gly Phe Leu
195 200 205
Gly Val Asn Val Phe Gly Arg Glu Leu Thr Ser Leu Glu Thr Leu Gly
210 215 220
Ser Ile Asn Ser Asp Val Thr Arg Ser Met Thr Ser Gly Thr His Ile
225 230 235 240
Ile Val Trp Gly Phe Leu Phe Val Leu Ala Leu Phe Ala Asn Arg Ile
245 250 255
Gly Phe Ser Lys Thr Leu Ile Ile Leu Cys Ile Phe Thr Gly Ala Gly
260 265 270
Ile Phe Leu Thr Tyr Gly Arg Ala Val Trp Gly Gly Thr Phe Leu Ala
275 280 285
Val Leu Phe Leu Cys Trp Lys Leu Gly Thr Lys Lys Met Leu Arg Ser
290 295 300
Val Gly Leu Ile Ala Ile Val Ala Val Phe Gly Leu Ser Ala Met Leu
305 310 315 320
Ala Ile Lys Pro Gly Ala Ile Glu Gly Ala Met Gln Arg Leu Phe Ser
325 330 335
Val Glu Glu Glu Val Ser His Gly Ser Ser Leu Gly Trp Arg Phe Tyr
340 345 350
Glu Asn Lys Met Ala Trp Ala Ala Ile Gln Arg Ser Pro Leu Leu Gly
355 360 365
Ile Gly Leu Gly Ala Pro Tyr Arg Pro Pro Ala Lys Ser Asp Val Thr
370 375 380
Ala Glu Gln Val Arg Tyr Val His Ser Ala Tyr Ile Tyr Leu Thr Leu
385 390 395 400
Lys Thr Gly Ile Ile Val Phe Met Ser Val Ile Phe Leu Ile Phe Lys
405 410 415
Ile Leu His Leu Thr Tyr Ile Gln Thr Arg Ser Asn Asp Leu Phe Ile
420 425 430
Ser Ser Val Ala Ile Ala Ser Phe Ala Ala Met Ile Glu Tyr Phe Leu
435 440 445
Ala Cys Ile Thr Gln Pro Glu Leu Met Gln Thr Pro Gly Ile Ala Phe
450 455 460
Leu Ala Thr Leu Ala Gly Leu Met Cys Ala Ala Asn Tyr Leu Asn Gln
465 470 475 480
Lys Asn Leu Thr Lys Gly Lys Leu Thr Ser
485 490
<210> 16
<211> 268
<212> PRT
<213> 鞭毛甲基菌
<400> 16
Met Asn Val Lys Thr Ser Pro Leu Ile Ser Ile Ile Thr Ala Thr Tyr
1 5 10 15
Asn Ser Met Lys Tyr Phe Glu Asp Thr Lys Lys Ser Val Leu Glu Gly
20 25 30
Asp Val Glu Asp Phe Glu Trp Ile Ile Val Asp Asp Gly Ser Thr Asp
35 40 45
Gly Thr Arg Lys Tyr Leu Gln Glu Ile Asp His Pro Asn Ile Lys Leu
50 55 60
His Phe Lys Ser Ile Asn Ala Gly Ile Glu Asp Ser Tyr Arg Thr Gly
65 70 75 80
Ile Glu Leu Ala Thr Gly Lys Tyr Leu Leu Ile Leu Asp His Asp Asp
85 90 95
Thr Ile Pro Leu Gly Ser Leu Ser Lys Arg Leu Asp Leu Leu Glu Ser
100 105 110
Asn Pro Asn Ala Leu Ala Ala Phe Gly Ala Val Ala Tyr Met Asp Glu
115 120 125
Ser Gly Arg Ile Tyr Lys Glu Ser Arg Phe Pro Phe Val Ser Asp Asp
130 135 140
Cys Val Leu Ser Ser Leu Phe Thr Leu Phe Gly Ile Phe Ile Leu Pro
145 150 155 160
Val Tyr Pro Leu Lys Gln Gly Cys Val Val Leu Arg Ser Ser Phe Val
165 170 175
Lys Asn Asn Pro Gly Leu Tyr Asp Ile Gln Leu Phe Leu Gln Ala Ala
180 185 190
Lys Leu Gly Pro Val Ile Phe Ile Lys Gln Ala Cys Leu Asn Tyr Arg
195 200 205
Thr Phe Arg Thr Gln Phe Ser Ser Ser Arg Lys Met Arg Leu Ile Arg
210 215 220
Phe Phe Gln Phe Val Trp Ala Lys Tyr Ala Phe Lys Phe Leu Pro Trp
225 230 235 240
Tyr Ile Ser Pro Phe Phe Ala Ile Tyr Lys Thr Ile Pro Glu Phe Phe
245 250 255
Lys Val Leu Trp Ser Phe Val Ser Ser Lys Arg Ile
260 265
<210> 17
<211> 322
<212> PRT
<213> 鞭毛甲基菌
<400> 17
Met Met Thr Asp Phe Ser Ser Lys Lys Lys Leu Asp Leu Ser Val Ala
1 5 10 15
Ile Val Phe Val Asn Tyr Asn Thr Ser Asp Gln Ile Ile Ser Cys Ile
20 25 30
Tyr Ser Leu Arg Glu Glu Arg Tyr Ser Lys Ile Ile Val Val Asp Asn
35 40 45
Ala Ser Pro Asp Asp Cys Pro Glu Cys Ile Val Glu Glu Phe Pro Asp
50 55 60
Val Val Leu Ile Lys Ser Glu Lys Asn Leu Gly Phe Gly Glu Gly Cys
65 70 75 80
Asn Ile Gly Lys Asp Trp Val Ile Val Asn Thr Asp Cys Glu Tyr Ile
85 90 95
Phe Phe Leu Asn Pro Asp Thr Leu Val Glu Pro Gly Leu Leu Gln Leu
100 105 110
Leu His Asp Gly Phe Phe Ser Pro Glu Val Gly Leu Val Thr Pro Arg
115 120 125
Ile Thr Met Met Gly Asp Gly Leu Asp Ile Leu Trp Tyr Gly Gly Gly
130 135 140
Tyr Met Asn Trp Leu Thr Gly Ser Ala Arg Val Pro Gly Cys Gly Leu
145 150 155 160
Ser Ala Val Ser Lys Ile Ala Leu Glu Asp Arg Phe Val Glu Phe Ala
165 170 175
Ser Gly Cys Ala Phe Met Ile Arg Arg Ser Val Leu Glu Glu Cys Gly
180 185 190
Gly Phe Asp Pro Arg Tyr Phe Met Tyr Glu Glu Asp Val Glu Leu Ser
195 200 205
Leu Arg Val Ile Ser Tyr Gly Tyr Lys Ile Tyr Tyr Met Pro Lys Ala
210 215 220
Val Val Arg His Leu Ala Gln Gly Ser Gln Gly Lys Glu Val Glu Ala
225 230 235 240
Val Gly Met Phe Lys Gly Arg Asn Pro Lys Leu Pro Phe Phe Val Tyr
245 250 255
Gln Thr Ala Lys Asn Arg Phe Leu Thr Val Phe Thr His Gly Thr Val
260 265 270
Leu Lys Lys Gly Leu Phe Leu Ile Gly Phe Met Leu Trp Val Phe Arg
275 280 285
Asn Ser Phe Glu Trp Val Arg Tyr Lys Arg Leu Asp Ala Tyr Asn Ala
290 295 300
Leu Phe Leu Gly Ile Lys Asp Phe Val Lys Tyr Thr Tyr Val Ser Gly
305 310 315 320
Lys Lys
<210> 18
<211> 382
<212> PRT
<213> 鞭毛甲基菌
<400> 18
Met Lys Glu Ile Asn Val Ala Phe Val Glu Pro Val Gly Ser His Gly
1 5 10 15
Gly Met Asp Tyr Tyr Asp Ser Gly Leu Cys Ala Gly Leu Leu His Gln
20 25 30
Gly Val Ser Ala Thr Trp Tyr Thr Cys Asp Ile Ser Lys Pro Cys Gly
35 40 45
Asn Arg Pro Ile Phe Met Gln Leu Thr Phe Val Asn Ile Trp Gly Lys
50 55 60
Asp Ala Thr Trp Arg Arg Gly Ala Arg Tyr Ile Leu Gly Leu Cys Arg
65 70 75 80
Ser Ile Lys His Ala Lys Lys Asn Tyr Ser Asn Ile Ala His Phe His
85 90 95
Phe Phe His Val Gly Val Leu Glu Phe Leu Ser Val Leu Phe Phe Arg
100 105 110
Leu Phe Gly Phe Lys Val Val Ala Thr Val His Asp Val Glu Ser Phe
115 120 125
Lys Pro Gly Leu Thr Phe Ser Ile Leu Leu Lys Trp Thr Tyr Phe Leu
130 135 140
Cys Asn Gln Leu Ile Val His Asn Gln Val Ser Lys Asp Glu Leu Ile
145 150 155 160
Asn Arg Ser Asn Val Ser Ile Asn Lys Ile His Val Ile Pro His Gly
165 170 175
Ser Tyr Ile Gly Leu Val Ala Pro Ser Met Pro Lys Ala Asp Ala Arg
180 185 190
Gln Ala Leu Asn Val Ser Ser Asp Glu Lys Val Ile Leu Phe Phe Gly
195 200 205
Gln Ile Lys Glu Val Lys Gly Leu Asp Leu Leu Ile Glu Ala Leu Gly
210 215 220
Leu Val Lys Asp Lys Leu Lys Pro Phe Lys Leu Val Ile Ala Gly Lys
225 230 235 240
Val Trp Lys Asp Asn Phe Ser Lys Tyr Gln Glu Leu Ile Ser Lys Asn
245 250 255
Gly Leu Asn Asp Phe Cys Lys Leu Asp Ile Arg Tyr Ile Pro Asp Gln
260 265 270
Glu Ile Ser Met Phe Tyr Ser Ala Ala Asp Leu Ile Val Leu Pro Tyr
275 280 285
Arg Lys Ile Tyr Gln Ser Gly Val Leu Leu Met Ala Met Ser Tyr Gly
290 295 300
Thr Pro Val Leu Ala Ser Asp Leu Pro Gly Met Ala Gln Ile Ile Asn
305 310 315 320
Asp Gly Glu Asn Gly Phe Leu Phe Ser Ala Gly Asn Tyr Ile Asp Leu
325 330 335
Ala Glu Lys Leu Val Lys Ile Phe Ser Tyr His Asp Leu Ser Arg Ile
340 345 350
Thr Leu Gln Ala Glu Asn Asp Met Arg Thr Arg Phe Ser Trp Asp Glu
355 360 365
Ile Ala Ile Lys Thr Ile Ser Val Tyr Gln Lys Ser Ile Ser
370 375 380
<210> 19
<211> 501
<212> PRT
<213> 鞭毛甲基菌
<400> 19
Met Gln Leu Ile Asn Ser Arg Arg Ile Val Leu Leu Ser Leu Phe Ser
1 5 10 15
Leu Met Pro Leu Val Gly Ile Ala Glu Val Tyr Lys Ser Thr Asp Val
20 25 30
Asp Gly Ser Thr Thr Tyr Ser Asp Thr Pro Gln Ala Asn Ser Gln Lys
35 40 45
Ile Lys Val Phe Pro Ser Asp Tyr Lys Lys Asn Val Lys Ser Glu Ala
50 55 60
Ala Ala Asn Lys Ser Arg Ser Asn Ser Ile Ser Ala Ala Asn Val Thr
65 70 75 80
Glu Ala Pro Ile Asp Glu Ser Ser Ser Asp Ser Asn Val Thr Ile Lys
85 90 95
His Ser Thr Ser Asn Lys Ser Ile Asn Ser Ser Asn Pro Ser Ala Ala
100 105 110
Gly Gly Ser Ser Ser Ala Gly Gly Ser Ser Ser Ala Gly Gly Ser Ser
115 120 125
Ser Ala Gly Gly Ser Ser Ser Ala Gly Gly Ser Ser Ser Ala Gly Gly
130 135 140
Ser Ser Ser Ala Gly Gly Ser Ser Ser Ala Gly Gly Ser Ser Ser Ala
145 150 155 160
Gly Gly Ser Ser Ser Glu Thr Thr Thr Ala Ala Ser Val Asp Lys Val
165 170 175
Ser Ala Ala Leu Gln Gly Pro Lys Ala Phe Leu Asn Ser Asp Asp Phe
180 185 190
Lys Glu Asn Ser Tyr Arg Gly Phe Asn Val Leu Gly Arg Lys Leu Ser
195 200 205
Ser Ala Asp Met Glu Asp Leu Glu Lys Phe Asn Val Asn Leu Ile Arg
210 215 220
Ser Val Ile His Leu Glu Lys Cys Lys Lys Cys Asn Asp Tyr Glu Ile
225 230 235 240
Ser Pro Val Glu Leu Ser Gln Met Asp Phe Leu Val Glu Ala Gly Arg
245 250 255
Lys Leu Gly Phe Tyr Val Ile Phe Ala Phe Asp Pro Lys Pro Ala Gly
260 265 270
Asp Gln Ala Ile Tyr Trp Asn Asn Gln Gln Leu Arg Glu Ser Ile Lys
275 280 285
Asn Asn Trp Val Thr Ile Ala Lys Arg Tyr Lys Asn Glu Thr Val Val
290 295 300
Ala Gly Phe Asp Leu Ile Asn Glu Pro Val Val Arg Pro Gly Ser Val
305 310 315 320
Trp Glu Lys Tyr Ala Thr Glu Leu Ile Thr Ala Ile Arg Lys Val Asp
325 330 335
Glu Asn His Ile Ile Phe Leu Glu Pro Ser Pro Trp Gly Leu Ala Ser
340 345 350
Ser Leu Glu Gln Phe Thr Pro Val Pro Phe Asn Asn Ile Val Tyr Ser
355 360 365
Phe His Phe Tyr Ser Pro Gln Glu Leu Thr His Gln Gly Leu Ala Ala
370 375 380
Tyr Pro His Ala Tyr Ile Tyr Pro Ser Glu Lys Trp Asp Lys Glu Tyr
385 390 395 400
Leu Asn Asn Arg Leu Asp Ile Ala Arg Asn Trp Ala Asn Lys Tyr Asn
405 410 415
Val Pro Leu Tyr Ile Gly Glu Phe Ser Ile Ile Arg Trp Ala Pro Ser
420 425 430
Gly Ser Arg Leu Arg Tyr Leu Thr Asp Val Val Glu Arg Phe Glu Gln
435 440 445
Glu Lys Trp Ser Trp Thr Tyr His Ser Tyr Arg Glu Tyr Ser Gly Trp
450 455 460
Asp Ala Glu Met Pro Asp Ser Ile Phe Lys Asn Asp Ala Ile Val Glu
465 470 475 480
Arg Gln Asn Asn Val Pro Val Leu Gln Leu Leu Met Lys Asn Phe Asn
485 490 495
Lys Asn Lys Lys Tyr
500
<210> 20
<211> 368
<212> PRT
<213> 鞭毛甲基菌
<400> 20
Met His Lys Lys Ile Ala Ile Leu Gly Thr Arg Gly Ile Pro Ala Ala
1 5 10 15
His Gly Gly Phe Glu Thr Phe Ala Glu His Leu Ala Ile Tyr Leu Glu
20 25 30
Arg Lys Gly Trp Lys Val Thr Val Tyr Cys Gln Val Asp Gly Asn Gly
35 40 45
Pro Met Tyr Glu Asp Met Trp Asn Gly Ile Lys Arg Val Asn Ile Pro
50 55 60
Ile Ser Ile Gln Gly Ser Leu Gly Thr Ile Leu Phe Asp Trp Lys Ser
65 70 75 80
Thr Ile His Ala Ser Asn Thr Tyr His Leu Ile Leu Thr Leu Gly Tyr
85 90 95
Asn Thr Ala Leu Phe Cys Gly Leu Tyr Arg Thr Lys Gly Ile Thr Asn
100 105 110
Leu Ile Asn Met Asp Gly Ile Glu Trp His Arg Lys Lys Trp Gly Ala
115 120 125
Val Ala Lys Leu Trp Phe Trp Ile Asn Asp Trp Ala Gly Ser Ile Leu
130 135 140
Gly Asn His Leu Ile Ala Asp His Pro Gln Ile Ala Arg His Leu Glu
145 150 155 160
Thr Arg Val Arg Pro Ser Lys Ile Thr Met Ile Pro Tyr Gly Ala Asp
165 170 175
Lys Val Ile Glu Ala Asn Gln Ala Val Leu Glu Glu Tyr Gly Leu Lys
180 185 190
Pro Phe Ser Tyr Ala Ile Leu Ile Ala Arg Ala Glu Pro Glu Asn Ser
195 200 205
Ile Leu Glu Val Val Lys Ala Trp Ser Ala Lys Pro Arg Gly Met Arg
210 215 220
Leu Val Val Leu Gly Lys Tyr Asn Pro Asp His Ala Tyr Gln Val Ala
225 230 235 240
Val Lys Ala Ala Gly Ser Asp Glu Val Leu Phe Pro Gly Ala Ile Tyr
245 250 255
Asp Lys His Val Val Glu Ser Leu Arg Tyr Phe Ser Arg Leu Tyr Ile
260 265 270
His Gly His Gln Val Gly Gly Thr Asn Pro Ser Leu Val Glu Ala Leu
275 280 285
Gly Ala Gly Asn Ala Val Leu Ala His Asp Asn Arg Phe Asn Arg Trp
290 295 300
Val Ala Gly Asp Lys Ala Ala Tyr Phe Ser Gly Glu Lys Asp Cys Glu
305 310 315 320
Ile Thr Leu Asp Glu Leu Leu Asn Asp Glu Val Arg Leu Arg Glu Met
325 330 335
Arg Ala Gly Ser Leu Ala Gln Tyr Asp Thr Leu Phe Thr Trp Asp Ser
340 345 350
Val Leu Gln Gln Tyr Glu Ala Leu Leu Thr Arg Phe Leu Pro Asn Lys
355 360 365
<210> 21
<211> 479
<212> PRT
<213> 鞭毛甲基菌
<400> 21
Met Gln Ile Gln Ala Val Ile Leu Ser Gly Gly Ser Gly Thr Arg Leu
1 5 10 15
Trp Pro Leu Ser Arg Glu Asn Tyr Pro Lys Gln Leu Leu Thr Leu Leu
20 25 30
Asp Asn Asp Ser Leu Leu Gln Ser Thr Leu Arg Arg Val Asp Pro Leu
35 40 45
Ile Gly Thr Glu Cys Ser Pro Ile Leu Val Cys Asn Glu Glu Tyr Arg
50 55 60
Phe Val Ile Ala Glu Gln Leu Arg Met Met Gly Arg Arg Gly Ser Ile
65 70 75 80
Leu Leu Glu Pro Val Gly Lys Asn Thr Ala Pro Ala Leu Thr Leu Ala
85 90 95
Ala Leu Glu Ala Ala Ser His Gly Gln Asp Pro Ile Leu Leu Val Met
100 105 110
Pro Ala Asp His Ala Ile Ile Asn Val Gln Asp Phe Gln Asp Thr Val
115 120 125
Arg Thr Gly Ala Glu His Ala Ala Ala Gly Lys Ile Val Thr Phe Gly
130 135 140
Ile Val Pro Asp Arg Ala Glu Thr Gly Tyr Gly Tyr Ile Lys Ser Gly
145 150 155 160
Ala Val Leu Glu Gly Phe Gly Ser Ala Phe Ser Ile Glu Gln Phe Val
165 170 175
Glu Lys Pro Asp Glu Ala Thr Ala Gln Gln Tyr Val Val Ser Gly Asn
180 185 190
Tyr Phe Trp Asn Ser Gly Leu Phe Met Met Arg Ala Thr Val Trp Leu
195 200 205
Asn Ala Ile Ala Lys Thr Arg Pro Asp Ile Leu Ser Ser Cys Lys Gln
210 215 220
Ala Trp Asp Gly Gln Gln Arg Asp Gly Asp Phe Val Arg Val Asp Lys
225 230 235 240
Leu Lys Phe Gln Gln Val Pro Ser Asp Ser Ile Asp Tyr Ala Val Met
245 250 255
Glu His Val Ala Arg Gly Ala Asp Asn Leu Pro Ala Gly Ile Val Ile
260 265 270
Pro Leu Asn Ala Gly Trp Ser Asp Val Gly Ala Trp Asp Ser Phe Gly
275 280 285
Lys Ile Leu Pro Gln Asp Asn Ala Gly Asn Ser His Leu Gly Asp Val
290 295 300
Leu Phe Asn Asp Cys Ser Asn Thr Leu Ala Val Ser Ser Gly Arg Leu
305 310 315 320
Leu Ala Cys Val Gly Leu Gln Asn Ile Ala Val Ile Glu Thr Ala Asp
325 330 335
Ala Val Leu Val Ile Asp Lys Ser Lys Thr Gln Asp Val Lys Lys Ile
340 345 350
Val Glu Gln Leu Lys Val Gln Lys Arg Pro Glu Ala Lys Thr His Arg
355 360 365
Lys Val His Arg Pro Trp Gly Trp Tyr Asp Ser Ile Asp Met Gly Ala
370 375 380
Arg Phe Gln Val Lys Arg Ile Val Val Asn Pro Gly Ala Thr Leu Ser
385 390 395 400
Leu Gln Met His His His Arg Ala Glu His Trp Ile Val Val Thr Gly
405 410 415
Thr Ala Lys Val Thr Arg Gly Asp Glu Glu Phe Leu Val Ser Glu Asn
420 425 430
Gln Ser Thr Tyr Ile Pro Leu Gly Val Thr His Met Leu Ala Asn Pro
435 440 445
Gly Lys Leu Pro Leu Glu Met Ile Glu Val Gln Ser Gly Ala Tyr Leu
450 455 460
Gly Glu Asp Asp Ile Val Arg Phe Asn Asp Gln Tyr Gly Arg Ser
465 470 475
<210> 22
<211> 306
<212> PRT
<213> 鞭毛甲基菌
<400> 22
Met Ala Thr Phe Asn Lys Ile Leu Leu Thr Gly Ile Asn Gly Gln Val
1 5 10 15
Gly His Ala Leu Tyr Pro Lys Leu Gln Ser Leu Gly Glu Val Val Ala
20 25 30
Leu Asp Arg Ser Gln Leu Asp Leu Ser Lys Pro Asp His Ile Arg Asp
35 40 45
Val Val Arg Gln Thr Lys Pro Asp Leu Ile Ile Asn Pro Ala Ala Tyr
50 55 60
Thr Ala Val Asp Lys Ala Glu Ser Glu Pro Glu Leu Ala Tyr Ala Ile
65 70 75 80
Asn Gly Thr Ala Pro Gly Ile Leu Ala Glu Glu Ala Ala Lys Leu Asn
85 90 95
Ala Leu Leu Val His Tyr Ser Thr Asp Tyr Val Phe Asp Gly Thr Lys
100 105 110
Thr Thr Pro Tyr Thr Glu Leu Asp Glu Thr Asn Pro Leu Ser Val Tyr
115 120 125
Gly Ala Ser Lys Leu Ala Gly Glu Lys Ala Ile Gln Glu Val Gly Ala
130 135 140
Asn His Leu Ile Phe Arg Thr Ser Trp Val Tyr Gly Ala Tyr Gly Lys
145 150 155 160
Asn Phe Met Arg Thr Ile Leu Arg Leu Ala Ala Glu Arg Asp Ser Leu
165 170 175
Asn Ile Val Ala Asp Gln Phe Gly Ala Pro Thr Ser Thr Glu Ser Ile
180 185 190
Ala Asp Ala Thr Ile Thr Ala Leu His Ala Trp Asp Gly Thr Gln Arg
195 200 205
Gly Val Tyr His Leu Val Asn Thr Gly Glu Thr Ser Trp His Gly Phe
210 215 220
Ala Leu Glu Ile Ile Arg Gln Tyr Gly Glu Ile Ala Gln Lys Lys Asn
225 230 235 240
Leu Ala Lys Leu Lys Ser Thr Val Glu Asn Val Val Gly Ile Thr Thr
245 250 255
Ala Glu Tyr Pro Thr Pro Ala His Arg Pro Ala Asn Ser Lys Met Ser
260 265 270
Thr Glu Lys Phe Met Ser Thr Phe Lys Thr Glu Leu Ala Pro Trp Glu
275 280 285
Leu Ala Leu Arg Ser Thr Val Thr His Leu Ala Thr Phe Ser Val Glu
290 295 300
Asn His
305
<210> 23
<211> 182
<212> PRT
<213> 鞭毛甲基菌
<400> 23
Met Asn Val Thr Pro Thr His Ile Pro Asp Val Ile Val Phe Glu Pro
1 5 10 15
Lys Ile Phe Gly Asp Ala Arg Gly Phe Phe Phe Glu Ser Phe Asn Gln
20 25 30
Lys Ala Phe Glu Glu Ala Val Gly Arg Lys Tyr Asp Phe Val Gln Asp
35 40 45
Asn His Ser Lys Ser Ser Lys Gly Val Leu Arg Gly Leu His Tyr Gln
50 55 60
Ile Gln Gln Ala Gln Gly Lys Leu Val Arg Val Val Ala Gly Glu Val
65 70 75 80
Phe Asp Val Ala Val Asp Ile Arg Lys Ser Ser Pro Thr Phe Gly Gln
85 90 95
Trp Val Gly Gln His Leu Ser Ala Glu Asn Lys Lys Gln Met Trp Val
100 105 110
Pro Pro Gly Phe Ala His Gly Phe Leu Val Leu Ser Glu Thr Ala Glu
115 120 125
Phe Leu Tyr Lys Thr Thr Asp Phe Tyr Ala Pro Ala His Glu Arg Cys
130 135 140
Leu Ser Trp Asn Asp Pro Val Val Gly Ile Glu Trp Pro Asp Ile Gly
145 150 155 160
Thr Pro Pro Leu Leu Ser Ser Lys Asp Gln Gln Gly Leu Gly Leu His
165 170 175
Gln Thr Glu Leu Phe Ala
180
<210> 24
<211> 292
<212> PRT
<213> 鞭毛甲基菌
<400> 24
Met Arg Lys Gly Ile Ile Leu Ala Gly Gly Ser Gly Thr Arg Leu Tyr
1 5 10 15
Pro Val Thr Gln Ala Val Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys
20 25 30
Pro Met Ile Tyr Tyr Pro Leu Ser Thr Leu Met Leu Ala Gly Ile Arg
35 40 45
Asp Ile Leu Leu Ile Ser Thr Pro Gln Asp Thr Pro Arg Phe Glu Gln
50 55 60
Leu Leu Gly Asp Gly Ser Gln Trp Gly Leu Asn Ile Ala Tyr Ala Val
65 70 75 80
Gln Pro Ser Pro Asp Gly Leu Ala Gln Ala Phe Ile Ile Gly Lys Lys
85 90 95
Phe Ile Gly Asn Asp Pro Ser Ala Leu Val Leu Gly Asp Asn Ile Phe
100 105 110
Tyr Gly His Asp Leu Ala His Asp Leu Ala His Ala Asp Gln Arg Gln
115 120 125
His Gly Ala Thr Val Phe Ala Tyr Pro Val His Asp Pro Glu Arg Tyr
130 135 140
Gly Val Val Glu Phe Asn Asp Ala Gly Gln Ala Ile Ser Leu Glu Glu
145 150 155 160
Lys Pro Lys Glu Pro Lys Ser Arg Tyr Ala Val Thr Gly Leu Tyr Phe
165 170 175
Tyr Asp Asn Gln Val Val Asp Ile Ala Ala Ser Leu Lys Pro Ser Pro
180 185 190
Arg Gly Glu Leu Glu Ile Thr Asp Val Asn Lys Ile Tyr Leu Glu Arg
195 200 205
Arg Ser Leu Asn Val Glu Leu Met Gly Arg Gly His Ala Trp Leu Asp
210 215 220
Thr Gly Thr His Glu Ser Leu Leu Glu Ala Ser Leu Phe Ile Glu Thr
225 230 235 240
Ile Glu Lys Arg Gln Gly Leu Lys Val Ala Cys Pro Glu Glu Ile Ala
245 250 255
Tyr Arg Lys Gly Tyr Ile Asp Ala Glu Gln Val Glu Lys Ile Ala Gln
260 265 270
Pro Tyr Leu Lys Asn Gly Tyr Gly Gln Tyr Leu Ile Arg Met Leu Lys
275 280 285
Glu Lys Val Phe
290
<210> 25
<211> 366
<212> PRT
<213> 鞭毛甲基菌
<400> 25
Met Thr Thr Leu Asn Asn Thr Ile Ile Val Thr Gly Gly Ala Gly Phe
1 5 10 15
Ile Gly Gly Asn Phe Val Leu Asp Trp Val Lys Ala Gly Leu Gly Thr
20 25 30
Val Ile Asn Leu Asp Lys Leu Thr Tyr Ala Gly Asn Leu Glu Asn Leu
35 40 45
Ala Asp Ile Glu Gly Asn Pro Asn His Ile Phe Val His Gly Asp Ile
50 55 60
Gly Asp Arg Ala Leu Val Ala Lys Leu Leu Ala Glu His Lys Pro Arg
65 70 75 80
Ala Val Ile Asn Phe Ala Ala Glu Ser His Val Asp Arg Ser Ile His
85 90 95
Gly Pro Glu Asp Phe Ile Gln Thr Asn Val Val Gly Thr Phe His Leu
100 105 110
Leu Glu Glu Val Arg Ala Tyr Trp Asn Ser Val Val Lys Thr His Pro
115 120 125
Glu Glu Lys Glu Asn Pro Gln Phe Arg Phe Leu His Val Ser Thr Asp
130 135 140
Glu Val Tyr Gly Thr Leu Gly Pro Lys Asp Gln Ala Phe Thr Glu Thr
145 150 155 160
Thr Pro Tyr Ala Pro Asn Ser Pro Tyr Ser Ala Ser Lys Ala Ala Ser
165 170 175
Asp His Leu Val Arg Ala Tyr His His Thr Tyr Gly Leu Pro Val Leu
180 185 190
Thr Thr Asn Cys Ser Asn Asn Tyr Gly Pro Tyr His Phe Pro Glu Lys
195 200 205
Leu Ile Pro Leu Cys Leu Leu Asn Ala Leu Ala Gly Lys Pro Leu Pro
210 215 220
Ile Tyr Gly Asp Gly Gln Gln Ile Arg Asp Trp Leu Phe Val Lys Asp
225 230 235 240
His Cys Ser Ala Ile Arg Arg Val Leu Glu Ala Gly Gln Leu Gly Glu
245 250 255
Thr Tyr Asn Val Gly Gly Trp Asn Glu Lys Ala Asn Leu Asp Val Val
260 265 270
Gln Thr Leu Cys Ser Ile Leu Asp Glu Leu Ser Pro Lys Ala Asp Gly
275 280 285
Ser Ser Tyr Lys Asp Gln Ile Thr Phe Val Lys Asp Arg Pro Gly His
290 295 300
Asp Arg Arg Tyr Ala Ile Asp Ala Ser Lys Leu Glu Arg Glu Leu Gly
305 310 315 320
Trp Lys Pro Ala Glu Thr Phe Glu Ser Gly Ile Arg Lys Thr Val Glu
325 330 335
Trp Tyr Leu Gln Asn Gln Ala Trp Val His Asn Val Thr Ser Gly Glu
340 345 350
Tyr Arg Asn Trp Val Ser Lys Gln Tyr Ser Gly Ser Ala Ala
355 360 365
<210> 26
<211> 334
<212> PRT
<213> 鞭毛甲基菌
<400> 26
Met Leu Leu Val Thr Gly Gly Thr Gly Tyr Ile Gly Ser His Ala Cys
1 5 10 15
Val Glu Leu Ile Asn Ala Gly Tyr Glu Val Val Val Leu Asp Asn Phe
20 25 30
Ser Asn Ser Gln Ala His Ile Val Asp Arg Ile Lys Gln Ile Thr Gly
35 40 45
Lys Ala Pro Val Leu Val Glu Gly Asp Val Arg Asp Glu Ala Leu Leu
50 55 60
Ser Asp Leu Phe Ser Arg Tyr Pro Phe Gln Ala Val Met His Phe Ala
65 70 75 80
Gly Leu Lys Ala Val Gly Glu Ser Val Ala Gln Pro Leu Arg Tyr Tyr
85 90 95
Asp Asn Asn Val Ala Gly Ser Val Thr Leu Leu Arg Val Met Gln Ala
100 105 110
His Asp Val Lys Arg Leu Val Phe Ser Ser Ser Ala Thr Val Tyr Gly
115 120 125
Asp Pro Ala Ser Val Pro Ile Arg Glu Asp Phe Pro Leu Ser Ala Thr
130 135 140
Asn Pro Tyr Gly Ala Ser Lys Leu Met Val Glu Asp Ile Leu Arg Asp
145 150 155 160
Leu Ala Val Ser Asp Pro Glu Trp Arg Ile Ala Ile Leu Arg Tyr Phe
165 170 175
Asn Pro Val Gly Ala His Glu Ser Gly Leu Ile Gly Glu Asn Pro Asn
180 185 190
Gly Met Pro Asn Asn Leu Met Pro Tyr Ile Thr Gln Val Ala Gln Gly
195 200 205
Gln Arg Glu Ser Leu Ser Val Phe Gly Ser Asp Tyr Pro Thr Val Asp
210 215 220
Gly Thr Gly Val Arg Asp Tyr Ile His Val Val Asp Leu Val Val Gly
225 230 235 240
His Leu Arg Ala Leu Glu Arg Leu Asp Lys Glu Ala Gly Val Phe Thr
245 250 255
Cys Asn Leu Gly Thr Gly Gln Gly Tyr Ser Val Leu Glu Met Val Lys
260 265 270
Ala Phe Glu Asp Ala Ser Gly Gln Ala Val Pro Tyr Gln Leu Val Ala
275 280 285
Arg Arg Pro Gly Asp Val Ala Ala Ser Tyr Thr Asp Pro Ala Tyr Ala
290 295 300
Glu Gln Ala Leu Gly Trp Lys Ala Thr Arg Gly Ile Glu Gln Met Cys
305 310 315 320
Lys Asp Ser Trp His Trp Gln Gln Asn Leu Ala Gln Arg Gly
325 330
<210> 27
<211> 472
<212> PRT
<213> 鞭毛甲基菌
<400> 27
Met Leu Leu Pro Val Ile Met Ser Gly Gly Ala Gly Ser Arg Leu Trp
1 5 10 15
Pro Val Ser Arg Glu Thr Leu Thr Lys Pro Phe Ile Glu Leu Pro Asp
20 25 30
Gly Arg Thr Leu Leu Gln Lys Thr Leu Gln Arg Thr Ala Cys Leu Asp
35 40 45
Gly Val Ser Glu Val Leu Thr Val Thr Asn Lys Glu Tyr Tyr Phe Leu
50 55 60
Thr Arg Asp Val Tyr Glu Ala Thr Asp Thr Asn Val Ser His Ser Tyr
65 70 75 80
Leu Leu Glu Thr Ile Gly Arg Asn Thr Ala Pro Ala Ile Ala Val Ala
85 90 95
Ala Leu His Ala Ala Ala Lys His Gly Glu Asp Val Val Leu Leu Val
100 105 110
Met Pro Ala Asp His Leu Ile Gly Asn Gln Lys Val Phe Ser Lys Ala
115 120 125
Val Thr Val Ala Thr Asp Met Ala Val Asn Gly Trp Ile Val Thr Phe
130 135 140
Gly Val Glu Pro Ser Thr Pro Glu Thr Gly Tyr Gly Tyr Ile Glu Gly
145 150 155 160
Gly Glu Ser Ile Gly Asp Ser Gly Ala Arg Arg Val Val Arg Phe Val
165 170 175
Glu Lys Pro Asp Leu Glu Thr Ala Glu Lys Tyr Ile Ala Leu Gly Arg
180 185 190
Phe Thr Trp Asn Ala Gly Ile Phe Cys Phe Thr Ala Lys Thr Ile Ile
195 200 205
Ala Ala Leu Ala Glu Tyr Val Pro Glu Val Leu Glu Ile Ala Lys Lys
210 215 220
Thr Leu Ala Ser Ser Asp Ser Lys Thr Glu Pro Val Val Leu Gly Glu
225 230 235 240
Glu His Phe Ala Ser Ser Pro Asp Ile Ser Ile Asp Tyr Ala Val Met
245 250 255
Glu Arg Ala Ser Lys Val Ala Val Val Ala Ala Asp Phe Asp Trp Ser
260 265 270
Asp Ile Gly Ser Trp Ser Ala Met Ala Glu Leu Val Gln Ser Asp Glu
275 280 285
Arg Gly Asn Arg Val Asn Gly Glu Ala Leu Leu Val Asp Ala Asn Asn
290 295 300
Cys Tyr Ile Gln Ser Asp Ser Arg Leu Val Ala Gly Ile Gly Ile Asp
305 310 315 320
Asn Leu Leu Val Val Asp Thr Pro Asp Ala Leu Leu Val Ala His His
325 330 335
Ser Arg Ala Gln Asp Val Lys Thr Val Val Lys Gln Leu Lys Leu Glu
340 345 350
Ser His Ser Ala Ala Asn Tyr His Arg Lys Val His Arg Pro Trp Gly
355 360 365
Thr Tyr Thr Val Leu Glu Glu Gly Ala Asn Phe Lys Ile Lys Cys Ile
370 375 380
Lys Val Lys Pro Gly Ala Ser Leu Ser Leu Gln Met His His His Arg
385 390 395 400
Ser Glu His Trp Val Val Val Ser Gly Ile Ala Lys Val Val Asn Gly
405 410 415
Glu Arg Glu Leu Leu Ile Asn Ala Asn Glu Ser Thr Tyr Ile Pro Ala
420 425 430
Gly His Lys His Arg Leu Glu Asn Pro Gly Leu Leu Asp Leu Val Ile
435 440 445
Ile Glu Val Gln Ser Gly Glu Tyr Leu Gly Glu Asp Asp Ile Val Arg
450 455 460
Phe Gln Asp Ile Tyr Gly Arg Thr
465 470
<210> 28
<211> 264
<212> PRT
<213> 鞭毛甲基菌
<400> 28
Met Ile Ser Met Leu Lys Ala Leu Trp Leu Tyr Arg Gly Phe Val Leu
1 5 10 15
Gly Ser Val Lys Arg Glu Phe Gln Ser Lys Tyr Arg Asn Ser Leu Leu
20 25 30
Gly Ala Val Trp Thr Val Leu Asn Pro Leu Ala Met Ile Val Val Tyr
35 40 45
Thr Val Ile Phe Ser Gln Val Met Lys Ala Arg Leu Pro Gly Val Asp
50 55 60
Ser Thr Phe Ala Phe Ser Ile His Leu Cys Ala Gly Ile Leu Thr Trp
65 70 75 80
Gly Leu Phe Ala Glu Ile Val Gly Arg Ser Gln Thr Thr Phe Ile Asp
85 90 95
Asn Ala Asn Leu Leu Lys Lys Leu Ser Phe Pro Arg Leu Cys Leu Pro
100 105 110
Val Ile Val Thr Ala Thr Ala Leu Val Asn Phe Ala Ile Val Phe Gly
115 120 125
Leu Phe Thr Ala Phe Leu Leu Leu Ile Gly Met Phe Ser Gly Trp Pro
130 135 140
Tyr Leu Val Leu Ile Pro Val Leu Ile Leu Met Ile Val Phe Ala Leu
145 150 155 160
Gly Leu Gly Ile Ile Leu Gly Val Leu Asn Val Phe Phe Arg Asp Val
165 170 175
Gly Gln Phe Phe Gly Ile Val Leu Ser Phe Trp Phe Trp Leu Thr Pro
180 185 190
Ile Val Tyr Pro Val Ser Ile Leu Pro Glu Arg Val Gln Asp Tyr Met
195 200 205
Arg Leu Asn Pro Met Ala Arg Leu Met Glu Ala Phe Gln Gly Ile Leu
210 215 220
Val Gln Ala Lys Trp Pro Asp Trp Tyr Ser Leu Trp Pro Val Phe Ala
225 230 235 240
Leu Ser Ile Val Leu Cys Leu Leu Gly Leu Ser Leu Phe Arg Lys His
245 250 255
Ala Gly Asp Met Val Asp Glu Leu
260
<210> 29
<211> 178
<212> PRT
<213> 鞭毛甲基菌
<400> 29
Met Asp Ser Ala Arg Ser Lys Phe Ser Tyr Pro Ala Arg Arg Asp Gly
1 5 10 15
Gly Ser Phe Ala Val Thr Ala Ala Lys Arg Ser Asn Thr Ser Ile Lys
20 25 30
Pro Asn Leu Ala Val Ile Asn Trp Met Leu Glu Gln Glu Asp Arg Met
35 40 45
Gly Leu Ser Thr Pro Arg Pro Tyr Arg Glu Phe Glu Glu Arg Val Tyr
50 55 60
Arg His Arg Asp Asp Leu Arg Arg Leu Ile His Ser Leu Val Ala Asp
65 70 75 80
Gly Lys Lys Ile Tyr Gly Tyr Gly Ala Ser Ala Lys Gly Asn Val Val
85 90 95
Leu Gln Phe Cys Gly Phe Thr Ser Glu Glu Ile Pro Ala Ile Ala Glu
100 105 110
Val Asn Glu Glu Lys Phe Gly Arg Val Thr Pro Gly Thr His Ile Pro
115 120 125
Ile Ile Ser Glu Lys Glu Ala Arg Ala Ala Lys Pro Asp Tyr Phe Leu
130 135 140
Val Leu Pro Trp His Phe Lys Asp Gly Ile Leu Arg Arg Glu Lys Asp
145 150 155 160
Phe Leu Ala Asp Gly Gly Arg Phe Ile Phe Pro Phe Pro Glu Ile Glu
165 170 175
Ile Val
<210> 30
<211> 346
<212> PRT
<213> 鞭毛甲基菌
<400> 30
Met Thr Ile Lys Thr Ala Ile Ile Thr Gly Ile Thr Gly Gln Asp Gly
1 5 10 15
Ala Tyr Leu Ala Glu Leu Leu Leu Ser Lys Gly Tyr Lys Val Tyr Gly
20 25 30
Thr Phe Arg Arg Thr Ser Ser Val Asn Phe Trp Arg Ile Glu Glu Leu
35 40 45
Gly Ile Glu Asn Asp Pro Asn Leu Leu Leu Val Glu Tyr Asp Leu Thr
50 55 60
Asp Leu Ser Ala Ser Ile Arg Leu Leu Gln Ser Thr Gly Ala Thr Glu
65 70 75 80
Val Tyr Asn Leu Ala Ala Gln Ser Phe Val Gly Val Ser Phe Glu Gln
85 90 95
Pro Ile Thr Thr Ala Glu Ile Thr Gly Val Gly Ala Leu Asn Leu Leu
100 105 110
Glu Ala Ile Arg Leu Val Asn Pro Asn Ile Arg Tyr Tyr Gln Ala Ser
115 120 125
Thr Ser Glu Met Phe Gly Lys Val Gln Ala Ile Pro Gln Thr Glu Asp
130 135 140
Thr Pro Phe Tyr Pro Arg Ser Pro Tyr Gly Val Ala Lys Leu Tyr Ala
145 150 155 160
His Trp Met Thr Val Asn Tyr Arg Glu Ser Tyr Gly Ile Phe Gly Ser
165 170 175
Ser Gly Ile Leu Phe Asn His Glu Ser Pro Leu Arg Gly Arg Glu Phe
180 185 190
Val Thr Arg Lys Ile Thr Asp Ser Val Ala Lys Ile Lys Leu Gly Lys
195 200 205
Leu Asp Cys Leu Glu Leu Gly Asn Leu Asp Ala Lys Arg Asp Trp Gly
210 215 220
Tyr Ala Lys Asp Tyr Val Glu Gly Met Trp Arg Ile Leu Gln Ala Asp
225 230 235 240
Glu Pro Asp Thr Phe Val Leu Ala Thr Asn Arg Thr Glu Thr Val Arg
245 250 255
Asp Phe Val Ser Met Ala Phe Lys Gly Ala Gly Ile Ala Val Glu Phe
260 265 270
Lys Gly Lys Gly Glu Asp Glu Val Ala Val Asp Thr Ala Thr Gly Lys
275 280 285
Ile Val Val Arg Val Asn Pro Lys Phe Tyr Arg Pro Ala Glu Val Asp
290 295 300
Leu Leu Ile Gly Ser Pro Ala Lys Ala Lys Ala Lys Leu Gly Trp Glu
305 310 315 320
Pro Lys Thr Thr Leu Glu Gln Leu Cys Gln Met Met Val Glu Ala Asp
325 330 335
Leu Arg Arg Asn Thr Glu Gly Phe Ser Phe
340 345
<210> 31
<211> 288
<212> PRT
<213> 鞭毛甲基菌
<400> 31
Met Arg Ile Leu Leu Thr Gly Ala Asp Gly Phe Thr Gly Arg His Phe
1 5 10 15
Leu Thr Ala Ala Lys Ala Ala Gly His Glu Val Val Ala Leu Arg Ala
20 25 30
Asp Leu Thr Asp Lys Ala Val Leu Gln Arg Glu Val Glu Ala Ala Arg
35 40 45
Pro Glu Ala Val Val His Leu Ala Ala Ile Ser Phe Val Gly His Ala
50 55 60
Asp Val Ser Ala Phe Tyr Asp Val Asn Val Ile Gly Thr Leu Asn Leu
65 70 75 80
Leu Asp Ala Leu Ala Gly Leu Ser Val Thr Pro Arg Ser Val Leu Leu
85 90 95
Ala Ser Ser Ala Asn Val Tyr Gly Asn Ala Ala His Ser Pro Ile Thr
100 105 110
Glu Glu Gln Ala Pro Ala Pro Val Asn His Tyr Ala Met Ser Lys Leu
115 120 125
Ala Met Glu His Met Ala Arg Thr Tyr Leu Asp Arg Leu Pro Leu Phe
130 135 140
Phe Val Arg Pro Phe Asn Tyr Thr Gly Pro Gly Gln Ala Glu Ser Phe
145 150 155 160
Val Ile Pro Lys Leu Val Ala His Phe Ala Cys Lys Ala Gln Thr Val
165 170 175
Glu Leu Gly Asn Leu Asp Val Glu Arg Glu Phe Asn Asp Val Ala Phe
180 185 190
Val Cys Glu Ala Tyr Leu Arg Leu Leu Asp Lys Ala Val Pro Gly Glu
195 200 205
Val Phe Asn Ile Cys Ser Gly Ala Pro Val Thr Leu Arg Ala Val Ile
210 215 220
Gly Met Leu Arg Glu Leu Thr Ala His Asp Ile Glu Val Lys Val Asn
225 230 235 240
Pro Gln Phe Val Arg Asn Asn Glu Ile Lys Thr Leu Cys Gly Asp Pro
245 250 255
Ser Lys Leu Phe Arg Thr Ile Gly Glu Gly Arg Leu Val Pro Leu Ala
260 265 270
Leu Thr Leu Lys Ile Met Leu Glu His Ala Thr Arg Lys Glu Lys Lys
275 280 285
<210> 32
<211> 380
<212> PRT
<213> 鞭毛甲基菌
<400> 32
Met Met Lys Val Gly Phe Gly Val Thr Val Leu Thr Arg Cys Leu Ala
1 5 10 15
Leu Gly Gly Ile Asp Gly Ile Gly Ser Tyr Thr Arg Glu Leu Met Lys
20 25 30
Arg Leu Glu Ala Asp Pro Ala Val Glu Leu Phe Pro Ile Ser Tyr Gly
35 40 45
Tyr Ser Pro Ser Gln Phe Pro Ile Gly Ser Arg Ala Pro Thr Thr Phe
50 55 60
Gly Arg Tyr Ala Pro Leu Ala Ala Val Ser Ala Val Ser Gly Phe Pro
65 70 75 80
Phe Leu Gly Thr Ala Gln Leu Lys Glu Arg Val Asp Leu Ile His Ala
85 90 95
Pro Asp His Leu Ile Pro Asn Tyr Gly Lys Val Pro Val Ile Ala Ser
100 105 110
Ile Met Asp Ala Ile Pro Leu Ser His Pro Glu Trp Val Ser Pro Lys
115 120 125
Leu Arg Lys Met Lys Asn Ala Leu Trp Lys Arg Ser Ala His Trp Ala
130 135 140
Ser His Ile Ile Thr Ile Ser Glu Tyr Ser Lys Gln Glu Ile Ser Gln
145 150 155 160
His Phe Gly Ile Glu Ala Gln Lys Ile Ser Ala Ile Pro Leu Gly Val
165 170 175
Asp Glu Arg Trp Phe Gln Pro Leu Glu Glu Glu Ala Met Lys Val Val
180 185 190
Leu Arg Arg Tyr Asn Leu Pro Gln Tyr Tyr Phe Leu Val Val Gly Thr
195 200 205
Leu Gln Pro Arg Lys Asn Val Gly Arg Val Ile Glu Ala Tyr Arg Ser
210 215 220
Leu Pro Gln Gly Ile Arg Asn Glu Val Pro Leu Val Ile Val Gly Arg
225 230 235 240
Ala Gly Trp Arg Cys Glu Asp Val Val Glu Met Leu Thr Ser Ser Ser
245 250 255
Ser Gly Asn Ser Leu Arg Trp Leu Lys His Leu Pro Asp Ala Asp Leu
260 265 270
Leu Ala Val Leu Lys Gly Ala Thr Ala Leu Val Phe Pro Ser Leu Tyr
275 280 285
Glu Gly Phe Gly Leu Pro Val Val Glu Ala Phe Ala Ala Gly Thr Pro
290 295 300
Val Ile Thr Ser Asn Thr Thr Ser Leu Pro Glu Val Ala Gly Asp Ala
305 310 315 320
Ala Met Leu Val Asn Pro Leu Asn Val Ser Asp Ile Ala Ala Ala Met
325 330 335
Gln Ser Met Leu Glu Gln Pro Glu Leu Ala Glu Ser Phe Arg Asn Lys
340 345 350
Gly Gln Glu Arg Ala Leu Ala Tyr Ser Trp Asp Lys Thr Ala Ser Met
355 360 365
Thr Leu Asp Val Tyr Lys Lys Thr Arg Glu Ala Ala
370 375 380
<210> 33
<211> 399
<212> PRT
<213> 鞭毛甲基菌
<400> 33
Met Ile Ile Arg Phe Leu Gly Ala Gln Trp Leu Ala Val Gly Phe Val
1 5 10 15
Gly Val Ile Ser Leu Ala Val Ser Ile Leu Ile Ala Arg Thr Leu Gly
20 25 30
Pro Asp Ser Phe Gly Val Tyr Ser Val Val Leu Ser Gly Gly Ala Ile
35 40 45
Ala Ala Ile Leu Leu Asp Gly Gly Phe Gly Arg Leu Leu Gln Arg Glu
50 55 60
Arg Ala His Pro Thr Pro Ala Leu Leu Arg Phe Leu Pro Ile Leu Pro
65 70 75 80
Gln Ala Ala Leu Gly His Val Ile Ile Ala Ala Ser Ile Phe Ser Leu
85 90 95
Ile Ala Leu Leu Val Leu Pro Lys His Ala Leu Thr Ile Val Ala Val
100 105 110
Ile Trp Phe Phe Ala Ala Ser Val Thr Asn Gln Phe Gly Leu Asn Ile
115 120 125
Leu Arg Gly Asp Gly Arg Met Val Arg Asp Ala Ser Trp Gln Met Gly
130 135 140
Asn Arg Thr Phe Thr Ala Ala Cys Val Cys Ile Val Ile Leu Met Gly
145 150 155 160
Ala Glu Lys Pro Trp Gln Val Phe Phe Ala Gln Phe Val Gly Ala Thr
165 170 175
Ala Phe Gly Leu Leu Ile Met His Tyr Leu Arg Thr Arg Pro Leu Trp
180 185 190
Lys Ile Pro Pro Thr Leu Tyr Ala Ala Thr Leu Pro Phe Val Trp Leu
195 200 205
Asp Leu Ala Thr Val Leu Tyr Phe Arg Ala Asp Met Leu Leu Leu Glu
210 215 220
Trp Leu Asp Val Ser Lys Phe Glu Val Gly Lys Tyr Gly Val Ala Cys
225 230 235 240
Arg Leu Ile Glu Ala Val Ile Leu Leu Ala Ser Pro Leu Cys Ile Ile
245 250 255
Leu Phe Arg Lys Phe Arg Leu Gly Ser Ala Ser Pro Arg Leu Met Leu
260 265 270
Arg Arg Met Leu Pro Val Leu Ala Gly Ala Leu Met Val Gly Val Phe
275 280 285
Phe Met Val Phe Phe Trp Leu Cys Ser Thr Pro Leu Ile Ala Val Ala
290 295 300
Tyr Gly Glu Ala Tyr Ala Gly Ala Asp His Ile Leu Ala Ile Leu Gly
305 310 315 320
Cys Ala Leu Leu Phe Ile Leu Pro Asn Gly Val Leu Asn Gln Ala Ala
325 330 335
Leu Ala Leu Gly Ile Glu Arg Trp Leu Ala Met Ser Ala Ser Phe Ala
340 345 350
Ala Val Leu Asn Ile Ala Gly Asn Leu Trp Leu Ile Pro Gln Tyr Gly
355 360 365
Leu Ile Gly Ala Ala Trp Met Thr Val Val Thr Glu Ala Val Leu Gly
370 375 380
Cys Cys Val Ala Leu Gly Leu Trp Arg His Arg Asn Arg Ser Val
385 390 395
<210> 34
<211> 377
<212> PRT
<213> 鞭毛甲基菌
<400> 34
Met Gln Asp Leu Ala Val Ala His Val Tyr Arg Thr Tyr Phe Pro Asp
1 5 10 15
Pro Pro Gly Gly Leu Gln Glu Ala Ile Arg Gln Ile Ala Leu Thr Thr
20 25 30
Gly Met Gln Gly Val Asp Asn Thr Val Phe Thr Leu Ser Pro Gln Pro
35 40 45
Arg Pro Ala Ile Leu Gln Arg Pro Glu Ala Cys Val Val Arg Cys Arg
50 55 60
Ser Trp Ala Ala Pro Ala Ser Cys Asp Leu Gly Gly Ile Gly Ala Phe
65 70 75 80
Leu Ala Phe Ser Arg Leu Ala Glu Lys Ser Asp Val Leu His Tyr Leu
85 90 95
Phe Pro Trp Pro Phe Ala Asp Val Leu His Thr Val Val Arg Pro Gly
100 105 110
Cys Pro Ala Val Met Thr Tyr Ile Ser Asp Val Val Arg Gln Gln Leu
115 120 125
Leu Gly Arg Leu Tyr Ala Pro Leu Met Trp Lys Val Leu Arg Gln Met
130 135 140
Arg Leu Val Val Ala Asn Ser Pro Ala Tyr Ala Arg Thr Ser Pro Val
145 150 155 160
Leu Ser His Pro Glu Ile Arg Glu Lys Val Arg Val Ile Pro Leu Gly
165 170 175
Ile Glu Glu Ser Ser Tyr Pro Lys Ser Gly Asp Glu Glu Ile Leu Gln
180 185 190
Arg Leu Gly Ile Gly Lys Asp Glu Pro Tyr Phe Leu Phe Ile Gly Val
195 200 205
Leu Arg Tyr Tyr Lys Gly Ala His Phe Leu Val Lys Ala Ala Lys Arg
210 215 220
Ile Gly Ala Lys Val Val Phe Ala Gly Ala Gly Pro Glu Gly Ala Arg
225 230 235 240
Leu Lys Ala Leu Ala Gly Glu Val Gly Ala Glu Asn Val Ile Phe Ala
245 250 255
Gly Met Val Thr Asn Ala Glu Lys Val Thr Leu Leu Gln Cys Cys Arg
260 265 270
Ala Leu Val Leu Pro Ser His Leu Arg Ser Glu Ala Tyr Gly Met Val
275 280 285
Leu Val Glu Ala Ala Met Phe Gly Lys Pro Leu Ile Ser Cys Glu Ile
290 295 300
Gly Thr Gly Thr Ser Tyr Val Asn His His Glu Glu Thr Gly Phe Val
305 310 315 320
Val Glu Pro Ala Ser Pro Glu Ala Leu Ala Ser Ala Met Ala Val Leu
325 330 335
Leu Ser Glu Asp Arg Leu Ala Thr Glu Met Gly Ala Ala Ala Arg Gln
340 345 350
Arg Tyr Glu Leu Leu Phe Ser Gly Pro Ala Leu Gly Lys Ala Tyr Ala
355 360 365
Ala Leu Phe Arg Glu Val Asp Ala Ser
370 375
<210> 35
<211> 313
<212> PRT
<213> 鞭毛甲基菌
<400> 35
Met Met Gln Leu Leu Val Thr Gly Ala Thr Gly Phe Val Gly Lys Thr
1 5 10 15
Leu Cys Ser Ala Leu Arg Arg Gln Ser Phe Pro Val Lys Ala Ile Gly
20 25 30
Arg Ala Gly Thr Ile Arg Ala Asp Ala Leu Gly Asp Gln Val Ala Ser
35 40 45
Ile Asp Gly Gln Thr Asp Trp Ser Leu Ile Leu Asp Gly Ile Asn Ala
50 55 60
Val Ile His Leu Ala Ala Arg Val His Val Met Arg Glu Gln Leu Ala
65 70 75 80
Asp Pro Leu Ala Ala Tyr Arg Glu Thr Asn Val Glu Gly Thr Leu Asn
85 90 95
Leu Ala Arg Gln Ala Ala Lys Ala Gly Val Lys Arg Phe Val Phe Ile
100 105 110
Ser Ser Ile Lys Val Asn Gly Glu Gln Thr Leu Pro Gly Lys Pro Phe
115 120 125
Thr Ala Tyr Asp Val Pro Ala Pro Glu Asp Ala Tyr Gly Ile Ser Lys
130 135 140
Phe Glu Ala Glu Gln Gly Leu Leu Ala Leu Ala Arg Glu Thr Gly Met
145 150 155 160
Asp Val Val Val Ile Arg Pro Pro Leu Val Tyr Gly Pro Gly Val Lys
165 170 175
Gly Asn Phe Ala Ser Met Met Lys Leu Val Lys Ser Gly Ile Pro Leu
180 185 190
Pro Leu Gly Ala Ile His Asn Gln Arg Ser Leu Val Ala Ile Asp Asn
195 200 205
Leu Val Asn Leu Ile Val Thr Cys Ile Asp His Pro Ala Ala Ala Asn
210 215 220
Gln Val Phe Leu Val Ser Asp Gly Glu Asp Leu Ser Thr Ser Asp Leu
225 230 235 240
Leu Arg Arg Leu Ala Lys Ala Ala Gly Val Ser Ser Arg Leu Met Pro
245 250 255
Val Ser Ala Arg Trp Leu Glu Met Gly Leu Arg Met Cys Gly Lys Arg
260 265 270
Leu Ile Ala Gln Arg Leu Leu Gly Ser Leu Gln Val Asp Ile Ser Lys
275 280 285
Thr Arg Glu Leu Leu Gly Trp Val Pro Pro Ile Ser Val Asp Glu Gly
290 295 300
Leu Lys Arg Cys Phe Ser Thr Lys Gly
305 310
<210> 36
<211> 183
<212> PRT
<213> 鞭毛甲基菌
<400> 36
Met Ile Arg Phe Phe Asp Ile Ile Phe Ser Val Ile Gly Leu Val Leu
1 5 10 15
Gly Phe Pro Leu Leu Leu Ser Ile Tyr Thr Leu Gly Leu Phe Asp Thr
20 25 30
Gly Ala Pro Leu Phe Arg Gln Val Arg Val Gly Arg Tyr Arg Gln Pro
35 40 45
Phe Thr Leu Val Lys Phe Arg Thr Met Lys Val Asp Thr Ala Ser Val
50 55 60
Ala Ser His Leu Ala Ser Thr Asn Ser Ile Thr Arg Leu Gly Arg Phe
65 70 75 80
Leu Arg Arg Thr Lys Leu Asp Glu Leu Pro Gln Leu Trp Asn Val Leu
85 90 95
Lys Gly Glu Met Ser Leu Val Gly Pro Arg Pro Asn Leu Phe Asn Gln
100 105 110
Glu Glu Leu Met Ala Glu Arg Glu Leu Arg Gly Val Tyr His Ala Arg
115 120 125
Pro Gly Ile Thr Gly Leu Ala Gln Val Asn Asp Ile Asp Met Ser Thr
130 135 140
Pro Arg Leu Leu Ala Glu Thr Asp Ala Arg Met Leu Arg Glu Met Asn
145 150 155 160
Val Arg Leu Tyr Phe Lys Leu Leu Ile Gln Thr Val Leu Gly Arg Gly
165 170 175
Gln Gly Asp Arg Val Val Arg
180
<210> 37
<211> 637
<212> PRT
<213> 鞭毛甲基菌
<400> 37
Met Leu His Tyr Phe Pro Ser Phe Lys Trp Ser Asn Tyr Ile Ser Leu
1 5 10 15
Lys Asn Pro Arg Ser Leu Ser Ala Trp Ile Tyr Asp Ile Val Ala Ala
20 25 30
Ala Leu Ala Trp Trp Ala Ala Phe Leu Leu Arg Phe Asn Phe Asp Ile
35 40 45
Pro Ala Asn Phe Val Gln Ser Met Leu Asp Ser Ala Ala Trp Val Ile
50 55 60
Pro Leu Gln Ala Phe Val Phe Leu Leu Ala Gly Leu Tyr Lys Gly Val
65 70 75 80
Trp Arg Phe Ala Ser Leu Pro Asp Leu Gln Arg Leu Val Arg Ala Ile
85 90 95
Ala Ile Ser Ala Val Leu Val Val Ala Ile Leu Phe Met Phe Lys Pro
100 105 110
His Gly Ile Val Pro Arg Ser Val Leu Ile Leu Asp Pro Met Leu Leu
115 120 125
Leu Leu Leu Met Gly Gly Ser Arg Phe Ala Tyr Arg Ala Trp Lys Glu
130 135 140
His Arg Leu Tyr Gly Ser Ala Gln Phe Ser Gly Lys Pro Val Leu Val
145 150 155 160
Leu Gly Ala Gly Glu Ala Ala Ile Ala Leu Leu Lys Asp Leu Ser Lys
165 170 175
Ser Arg Glu Trp His Val Val Gly Leu Leu Asp Asp Lys Lys Thr Met
180 185 190
His Gly Arg Glu Leu Leu Gly Val Asn Val Leu Gly Ser Ile Ala Gln
195 200 205
Leu Pro Gln Ile Ala Ala Asp Leu Ser Val Asn His Val Ile Val Ala
210 215 220
Met Pro Ser Ala Arg His Gln Arg Arg Arg Glu Ile Val Glu Leu Ala
225 230 235 240
Ser Arg Asn Gly Leu Thr Ala Leu Thr Val Pro Ser Phe Asp Asp Leu
245 250 255
Met Ser Gly His Leu Ser Met Ala Gln Ile Arg Pro Val Glu Val Glu
260 265 270
Asp Leu Leu Gly Arg Glu Pro Val Ser Leu Asp Gly Glu Gly Leu Gln
275 280 285
His Leu Ile Glu Gly Gln Val Leu Leu Ile Thr Gly Ala Gly Gly Ser
290 295 300
Ile Gly Ser Glu Leu Cys Arg Gln Val Leu Lys Tyr Arg Pro Ala Cys
305 310 315 320
Leu Val Cys Leu Asp Gln Ser Glu Tyr Ala Leu Tyr Arg Leu Glu Gln
325 330 335
Glu Phe Asp Asn Leu Glu Phe Asp Thr Arg Ile Glu Tyr Val Val Gly
340 345 350
Asp Val Arg Asn Ala Arg Arg Val Gly Gln Val Leu Gly Arg Tyr Met
355 360 365
Pro Lys Leu Val Phe His Ala Ala Ala Tyr Lys His Val Pro Leu Met
370 375 380
Glu Asn Arg Asn Val Ala Glu Ser Leu Ser Asn Asn Val Ser Gly Thr
385 390 395 400
Tyr Thr Leu Ala Gln Ala Cys Lys Thr Ala Gly Val Ala Lys Phe Val
405 410 415
Leu Ile Ser Thr Asp Lys Ala Val Asn Pro Thr Asn Val Met Gly Ala
420 425 430
Ser Lys Arg Leu Ala Glu Met Ile Cys Gln Gly Leu Gln Glu Glu Ser
435 440 445
Gly Thr Arg Phe Ile Val Val Arg Phe Gly Asn Val Leu Gly Ser Ser
450 455 460
Gly Ser Val Ile Pro Lys Phe Arg Glu Gln Ile Ala Ala Gly Gly Pro
465 470 475 480
Ile Thr Val Thr His Pro Glu Ile Thr Arg Tyr Phe Met Ser Ile Pro
485 490 495
Glu Ala Cys Gln Leu Val Met Gln Ala Gly Leu Met Gly Gly Gly Gly
500 505 510
Glu Ile Phe Val Leu Asp Met Gly Asp Pro Val Arg Ile Val Asp Leu
515 520 525
Ala Arg Asp Met Ile Arg Leu Ser Gly Leu Asn Glu Asp Asp Ile Gln
530 535 540
Ile Val Tyr Ser Gly Leu Arg Pro Gly Glu Lys Leu Tyr Glu Glu Leu
545 550 555 560
Leu Ala Asp Asp Glu Leu Thr Val Pro Thr Pro His Asp Lys Leu Arg
565 570 575
Ile Ala Val Ala Arg Ser Val Asp Gly Ala Trp Val Gln Ala Leu Leu
580 585 590
Lys Trp Ile Asp Arg Ala Ser Leu Ile Asp Glu Ser Val Ile Lys Gln
595 600 605
Glu Leu Gly Met Trp Val Glu Glu Tyr Ala Gly Asp Ile His Ala Asn
610 615 620
Pro Ser Met Met Phe Pro Pro Glu Ser Ser Thr Ile His
625 630 635
<210> 38
<211> 291
<212> PRT
<213> 鞭毛甲基菌
<400> 38
Met Ala Lys Lys Ile Thr Lys Ala Val Phe Pro Val Ala Gly Leu Gly
1 5 10 15
Thr Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro
20 25 30
Ile Val Asp Lys Pro Leu Ile Gln Tyr Ala Ala Glu Glu Ala Val Ala
35 40 45
Ala Gly Ala Thr Glu Leu Ile Phe Ile Ile Gly Arg Asn Lys Arg Thr
50 55 60
Ile Pro Asp His Phe Asp Lys Ser Phe Glu Leu Glu Ala Thr Leu Glu
65 70 75 80
Ala Ser Lys Lys Thr Lys Val Leu Glu Glu Ile Arg Asn Ile Leu Pro
85 90 95
Lys Asn Val Ser Cys Ile Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu
100 105 110
Gly His Ala Val Leu Leu Ala Lys Ser Val Val Gly Ser Glu Pro Phe
115 120 125
Ser Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Asp Lys Pro Ala Met
130 135 140
Gln Gln Met Thr Glu Leu Phe Asp Gln Glu Gly Val Ser Ile Leu Gly
145 150 155 160
Val Glu Asp Val Glu Pro Ser Glu Thr Ala Ser Tyr Gly Ile Val Asp
165 170 175
Ala Thr Glu Val Ser Gly Pro Asn Val Leu Gln Leu Asn Gly Ile Val
180 185 190
Glu Lys Pro Gln Pro Glu Glu Ala Pro Ser Asn Leu Ala Val Val Gly
195 200 205
Arg Tyr Ile Leu Thr Pro Glu Ile Phe Glu Cys Leu Glu Asn Val Lys
210 215 220
Pro Gly Lys Gly Gly Glu Ile Gln Leu Thr Asp Gly Ile Ala Ala Leu
225 230 235 240
Met Glu Lys Gln Lys Ile Leu Ala Tyr Arg Phe Asp Gly Lys Arg Tyr
245 250 255
Asp Cys Gly Ser Lys Leu Gly Tyr Val Lys Ala Asn Val Glu Tyr Ser
260 265 270
Leu Lys His Glu Glu Phe Gly Lys Glu Phe Ala Gln Tyr Leu Arg Asp
275 280 285
Leu Thr Lys
290
<210> 39
<211> 272
<212> PRT
<213> 糖原甲基菌
<400> 39
Met Leu Gln Gln Phe Ser Ile Gly Val Arg Glu His His His Lys Glu
1 5 10 15
Leu Thr Pro Asp Gln Ala Gly Ala Phe Leu Glu Val Val Asp Ala Ser
20 25 30
Leu Arg Ile Lys Lys Lys Ala Gln Phe Phe Ser Trp Leu Gln Gly Tyr
35 40 45
Phe Gln Phe Leu Leu Pro His Glu Val Leu Leu Cys Gly Leu Ser Ile
50 55 60
Gly Ala Gly Arg Pro Phe Thr Leu Glu Thr Phe Ser Ser Thr Arg Tyr
65 70 75 80
Val Thr Asp Thr His Thr Ala Val Ser Met Gln Glu Thr Asp Gly Val
85 90 95
Val Leu Arg Ala Ile Gln Ser Trp Gln Glu Thr Ser Leu Pro Val Leu
100 105 110
Val Asp Pro Tyr Leu Arg Pro Gly Ser Phe Gly Asn Phe Thr Val Pro
115 120 125
Glu Ile Asp Gln Ala Asn Leu Gln Ala Ser Glu Leu Arg Asn Leu Ala
130 135 140
Ala Tyr Gly Leu Ser Ser Ala Asp Gly Ser Ile Ser Ser Phe Phe Cys
145 150 155 160
Phe Ser Arg Val Ala Gly Glu Leu Asn Gly Asn His Ala Tyr Leu Leu
165 170 175
Glu Leu Leu Val Pro Tyr Leu His Ser Val Leu Met Arg Val Ser Asp
180 185 190
Ser Ala Thr Ala Ser Ala Asp Met Leu Gly Asp Ser Ser Val Ala Gly
195 200 205
Leu Ile Thr Met Arg Glu Lys Glu Ile Leu His Trp Val His Thr Gly
210 215 220
Lys Ser Asn Trp Glu Ile Ala Thr Ile Leu Gln Ile Ser Pro Leu Thr
225 230 235 240
Val Lys Asn His Met Gln Asn Ile Leu Arg Lys Leu Asp Val Gln Asn
245 250 255
Arg Ser His Ala Ala Ser Lys Ala Phe Arg Leu Gly Leu Ile Arg Asn
260 265 270
<210> 40
<211> 379
<212> PRT
<213> 糖原甲基菌
<400> 40
Met Gly Tyr Ser Asp Pro Val Leu Ala Arg Glu Gly Asp Val Ile Arg
1 5 10 15
Pro Tyr Val Ser Ala Thr Tyr Val Tyr Asp Asp Asn Leu Arg Arg Arg
20 25 30
Ser Asp Lys Glu Ser Asp Thr Ser Val Val Gly Arg Val Gly Ile Ile
35 40 45
Leu Asp Lys Asp Ile Ser Gln Gln Asn Phe Tyr Ala Asn Ile Gly Val
50 55 60
Asn Glu Thr Lys Tyr Asn Lys Asn Ser Glu Leu Asp Asn Thr Gly Lys
65 70 75 80
Asp Ile Val Ala Arg Trp Asn Trp Ala Val Gly Ser Gln Phe Arg Gly
85 90 95
Lys Val Glu Tyr Tyr Lys Asn Glu Ala Met Leu Pro Phe Ala Asp Phe
100 105 110
Arg Gly Val Glu Leu Asn Met Arg Ile Gln Glu Arg Lys Thr Phe Glu
115 120 125
Ala Asn Trp Arg Phe His Ser Ser Trp Arg Ala Arg Phe Gly Val Gln
130 135 140
Arg Gln Asp Val Glu Tyr Asp Ser Gln Thr Leu Asn Ala Ala Ser Phe
145 150 155 160
Gln Glu Asn Ser Gln His Val Gly Leu Asp Tyr Leu Ala Glu Ser Gly
165 170 175
Ser Lys Val Gly Leu Val Phe Thr Asn Gly Arg Gly Thr Arg Pro Phe
180 185 190
Asp Arg Pro Ala Phe Phe Pro Gly Ile Gly Thr Val Phe Val Asn Asn
195 200 205
Asp Tyr Arg Gln Gln Ser Leu Lys Ala Asp Ile Leu Trp Leu Tyr Ser
210 215 220
Ala Lys Thr Arg Phe Glu Phe Leu Gly Gly Tyr Val Asp Arg Lys His
225 230 235 240
Asp Ser Phe Ser Gln Arg Asp Phe Ser Gly Phe Asn Ala His Gly Asn
245 250 255
Met Val Trp Ser Ile Thr Asp Lys Thr Ser Phe Lys Thr Ala Ala Trp
260 265 270
Arg Asp Ala Asn Ala Ile Ser Ile Val Thr Ala Ser Tyr Val Ile Asp
275 280 285
Ser Gly Ala Ser Ala Ser Ile Ser Tyr Ser Ala Thr Ser Lys Ile Leu
290 295 300
Leu Ser Thr Ser Ala Arg Tyr Gln Gln Leu Lys Phe Glu Gly Asp Ile
305 310 315 320
Thr Gly Gln Asp Gln Gly Arg Thr Asp Lys Asn Lys Val Phe Ser Phe
325 330 335
Gly Val Thr Tyr Ser Pro Leu Glu Ser Leu Ser Phe Thr Thr Gly Leu
340 345 350
Asn Arg Ser Leu Arg Asp Ser Thr Ser Pro Ile Leu Asn Tyr Asn Ser
355 360 365
Thr Ser Ile Ser Leu Thr Gly Arg Tyr Glu Phe
370 375
<210> 41
<211> 449
<212> PRT
<213> 糖原甲基菌
<400> 41
Met Thr Val Asn Asp Ile Pro Leu Val Ala Phe Phe Lys Gln Leu Leu
1 5 10 15
Asp Pro Leu Ile Ile Leu Gly Thr Leu Tyr Val Phe Thr Leu Leu Phe
20 25 30
Gly Glu Pro Phe Asn Gly Tyr Tyr Leu Ile Leu Ala Leu Leu Ala Tyr
35 40 45
Phe Val Ser Ser Asn Val Tyr Glu Arg Leu Asp Leu Tyr Arg Thr Trp
50 55 60
Arg Ser Gly Lys Ile Leu Gly Tyr Ile Arg Asp Ile Leu Phe Gly Trp
65 70 75 80
Gly Ile Val Ile Ala Val Leu Met Phe Ile Gly Tyr Ala Ala Asp Leu
85 90 95
Ser Ser Gln Tyr Leu Asp Glu Met Ile Tyr Ala Trp Phe Ala Ser Val
100 105 110
Pro Met Ile Phe Ile Val Thr His Leu Ala Ile Arg Lys Ile Ala Ser
115 120 125
Asp Leu His Lys Asn Gly Glu Val Arg Ser Val Val Ile Ile Gly Ala
130 135 140
Asn Asp Ile Gly Val Arg Leu Ile Asn Arg Ile Thr Asp Asp Pro Tyr
145 150 155 160
Leu Phe Met Glu Val Lys Gly Ile Phe Asp Asp Arg Glu Val Ala Arg
165 170 175
His Pro Lys Gly Met Arg Asn Leu Pro Leu Leu Gly Ser Met Ser Glu
180 185 190
Ile Ala Pro Tyr Val Arg Ala Asn Asn Thr Gln Ile Ile Phe Ile Ser
195 200 205
Leu Pro Met Ser Ala Gln Pro Arg Ile Arg Gln Leu Phe Glu Glu Leu
210 215 220
Gln Asp Thr Thr Ala Ser Ile Tyr Phe Val Pro Asp Ile Tyr Ile Phe
225 230 235 240
Asp Leu Val Gln Ala Arg Phe Asp Asp Val Ala Gly Val Pro Val Val
245 250 255
Ala Ile Leu Glu Thr Pro Phe Thr Gly Phe Asn Ser Leu Ile Lys Arg
260 265 270
Thr Ser Asp Ile Ile Leu Ala Ser Leu Ile Leu Leu Met Leu Ser Pro
275 280 285
Ile Met Leu Thr Leu Ala Leu Ala Val Lys Leu Thr Ser Pro Gly Pro
290 295 300
Val Ile Phe Lys Gln Arg Arg Tyr Ala Glu Trp Gly Asn His Cys Leu
305 310 315 320
Ile Pro Leu His Glu Ser Asn Gly Arg Trp Gln Gly Ser Thr Gly Ala
325 330 335
Glu Ala Arg Ser Ala Ile Asp Thr Asp Trp Trp Phe Leu Ala Gln Glu
340 345 350
Leu Thr Gly Ala Ala Ala Val His Gln Cys Val Ala Arg Ser Asp Glu
355 360 365
Tyr Arg Gly Ala Thr Ala Cys Arg Phe Ser Ala Ile Ser Gln Ala Asp
370 375 380
Ser Trp Leu Tyr Ala Ala Ala Gln Gly Gln Ala Trp Asn Asn Arg Leu
385 390 395 400
Gly Ala Gly Glu Trp Phe Thr Trp Asn Tyr Leu Gly Gln Asp Gly Val
405 410 415
Pro Tyr Arg Val Leu Gly Leu Phe Ala Pro Leu Val Pro Gly Phe Leu
420 425 430
Leu Asp Tyr Arg Gln Asp Gly Ala Gly Cys Val Gln Lys Arg Arg Leu
435 440 445
Leu
<210> 42
<211> 310
<212> PRT
<213> 糖原甲基菌
<400> 42
Met Asn Asn Gly Phe Val Thr Asn Phe Lys Gln Ser Arg Thr Leu Cys
1 5 10 15
Val Gly Ala Val Ile Val Leu Ala Phe Ala Leu Ser Gly Cys Gly Asp
20 25 30
Lys His Glu Ser Lys Ala Ser Gln Ser Leu Val Lys Val Asn Gly Lys
35 40 45
Glu Ile Thr Val His Gln Leu Asn Gln Glu Leu Gly Arg Ala Asn Ile
50 55 60
Gln Glu Asn Gln Arg Glu Gln Ala Thr Gln Gln Ile Leu Thr Ala Leu
65 70 75 80
Ile Asp Arg Gln Leu Leu Glu Glu Ala Ala Leu Lys Ala Lys Val Asp
85 90 95
Arg Asp Pro Asn Val Met Thr Thr Ile Glu Arg Ala Lys Ser Gln Ile
100 105 110
Ile Ala Gln Ala Tyr Leu Gln Ser Lys Leu Gly Ser Val Ala Lys Pro
115 120 125
Ser Lys Thr Glu Ile Glu Asn Phe Tyr Asn Glu Asn Pro Gln Phe Phe
130 135 140
Ser Lys Arg Arg Met Val Glu Met Asp Gln Leu Leu Ile Asp Thr Lys
145 150 155 160
Phe Ala Asn Asp Glu Leu Lys Thr Ala Leu Gly Lys Leu Lys Thr Leu
165 170 175
Gln Glu Val Ala Ala Trp Met Asp Ala His Asn Ile Gln Tyr Asp Gln
180 185 190
Gly Gln Val Ser Arg Ser Val Ala Glu Leu Pro Pro Gln Ile Ser Glu
195 200 205
Arg Leu Lys Ala Glu Asp Lys Gly Lys Leu Phe Val Ile Gly Met Gly
210 215 220
Pro Arg Thr Met Leu Ile Met Met Asn Glu Ile Lys Asp Ser Pro Val
225 230 235 240
Ser Leu Ala Glu Ala Thr Pro Gln Ile Glu Asn Asn Leu Leu Asn Lys
245 250 255
Ala Arg Lys Glu Val Ala Glu Asn Glu Val Lys Arg Leu Lys Ala Asp
260 265 270
Ala Lys Ile Glu Tyr Ile Asp Lys Lys Met Glu Thr Ala Thr Glu Thr
275 280 285
Lys Ala Ala Lys Lys Lys Pro Ser Ser Thr Glu Asp Asp Ile Ala Ser
290 295 300
Gly Val Ser Gly Leu Lys
305 310
<210> 43
<211> 264
<212> PRT
<213> 糖原甲基菌
<400> 43
Met Lys Lys Leu Met Thr Trp Phe Phe Leu Leu Met Leu Ser Leu Thr
1 5 10 15
Pro Phe Val Thr His Ala Ala Glu Gly Asp Ile Leu Leu Gly Ala Gly
20 25 30
Asp Val Leu Lys Ile Ser Val Phe Glu Gln Pro Asp Leu Ser Leu Glu
35 40 45
Val Arg Val Ser Glu Ser Gly Ser Ile Thr Tyr Pro Leu Ile Gly Glu
50 55 60
Val Arg Val Gly Gly Gly Thr Val Ala Ala Ala Glu Gln Arg Ile Ala
65 70 75 80
Thr Met Leu Glu Lys Gly Gly Phe Leu Lys Ser Ala His Val Asn Ile
85 90 95
Ile Val Ala Gln Leu Gln Ser Leu Gln Val Ser Ile Leu Gly Gln Val
100 105 110
Asn Arg Pro Gly Arg Tyr Pro Ile Asp Ser Ala Lys Thr Leu Ala Asp
115 120 125
Val Leu Ala Leu Ala Gly Gly Val Ser Pro Glu Gly Gly Asp Leu Ile
130 135 140
Thr Leu Val His Asn Val Asp Gly Lys Ala Val Arg Asp Gln Ile Asp
145 150 155 160
Leu Ala Asp Met Met Arg Thr Gly Asp Leu Ser Lys Asn Ile Arg Val
165 170 175
Ala Gly Gly Asp Ile Ile Tyr Val Glu Arg Phe Asp Lys Phe Tyr Ile
180 185 190
Tyr Gly Gln Val Gln Arg Ala Ser His Tyr Arg Leu Glu His Glu Met
195 200 205
Thr Val Leu Gln Ala Leu Ser Val Gly Gly Gly Leu Ser Pro Arg Gly
210 215 220
Thr Glu Lys Gly Val Lys Ile Lys Arg Arg Asp Ala Ser Gly His Ile
225 230 235 240
Glu Val Ile Thr Ala Lys His Asp Asp Leu Ile Lys Pro Asn Asp Val
245 250 255
Ile Tyr Val Gln Glu Ser Phe Phe
260
<210> 44
<211> 462
<212> PRT
<213> 糖原甲基菌
<400> 44
Met Ser Phe Ser Gln Leu Leu Leu Ile Phe Lys Ala Arg Tyr Lys Ile
1 5 10 15
Leu Leu Ser Thr Ile Val Val Ala Leu Val Val Ala Ile Ala Leu Asn
20 25 30
Ile Phe Leu Pro Asn Ser Tyr Lys Ala Thr Thr Ser Ile Leu Val Asn
35 40 45
Tyr Lys Gly Val Asp Pro Val Thr Gly Met Ala Val Pro Ala Gln Leu
50 55 60
Leu Pro Gly Tyr Met Gly Thr Gln Val Asp Ile Ile Thr Ser Lys Lys
65 70 75 80
Ile Ala Lys Arg Val Val Thr Thr Leu Lys Leu Asn Glu Ser Ser Glu
85 90 95
Val Val Glu Ser Phe Asn Asp Ser Thr Gly Gly Glu Gly Asp Ile Val
100 105 110
Asp Trp Leu Ala Asp Leu Leu Ile Ser Arg Ile Glu Val Gln Pro Ala
115 120 125
Arg Asn Ser Ser Val Leu Gln Leu Glu Phe Asp Gly Ala Asn Pro Lys
130 135 140
Phe Ala Ala Val Val Ala Asn Ser Phe Ala Glu Glu Tyr Ile Lys Ala
145 150 155 160
Thr Ile Glu Leu Lys Val Glu Pro Ser Lys Lys Ala Ala Glu Phe Tyr
165 170 175
Thr Gly Gln Leu Lys Asp Leu Arg Ala Asp Ile Thr Arg Ala Gln Gln
180 185 190
Lys Leu Ser Asp Tyr Gln Gln Asp Lys Ser Ile Val Ser Val Asp Glu
195 200 205
Arg Leu Asp Ile Glu Arg Ala Lys Leu Asn Glu Leu Ser Ser Gln Leu
210 215 220
Val Met Ser Gln Gly Gln Thr Leu Glu Ala Gln Ser Arg Gln Thr Gly
225 230 235 240
Ala Gln Gly Ser Asn Ala Tyr Gly Ser Pro Asp Val Ala Ser Asn Pro
245 250 255
Met Val Leu His Leu Lys Thr Glu Ile Ala Arg Ser Glu Ser Arg Phe
260 265 270
Ala Asp Ile Ser Gln Lys Tyr Glu Arg Asn His Pro Leu Tyr Gln Gly
275 280 285
Ala Lys Ala Glu Leu Asp Asn Leu Lys Ser Glu Leu Ser Lys Gln Ile
290 295 300
Gln Ala Ala Thr Val Asn Ile Ser Ser Asn Tyr Arg Ile Leu Lys Gln
305 310 315 320
Arg Glu Ser Glu Ile Arg Asn Ala Leu Ala Glu Gln Lys Thr Lys Val
325 330 335
Met Leu Leu Asn Lys Asp Arg Asp Ala Leu Thr Val Leu Thr Arg Glu
340 345 350
Val Glu Gly Ala Gln Arg Ala Tyr Glu Leu Ala Thr Gln Arg Tyr Thr
355 360 365
Gln Ile Asn Leu Glu Gly Gln Ser Asn Gln Ala Asp Val Ser Ile Leu
370 375 380
Asn Pro Ala Thr Pro Pro Leu Lys Pro Ser Ser Pro Lys Lys Ile Leu
385 390 395 400
Asn Val Ala Val Ala Leu Val Leu Gly Thr Ile Phe Gly Leu Leu Phe
405 410 415
Ser Leu Leu Ala Glu Leu Thr Asn Glu Arg Ile Arg Ser Glu Arg Val
420 425 430
Leu Val Glu Ile Val Gly Ala Pro Leu Leu Gly Val Ile Asp Lys Asn
435 440 445
Lys Thr His Ser Arg Ile Gln Arg Leu Leu Ala Lys Lys Pro
450 455 460
<210> 45
<211> 292
<212> PRT
<213> 糖原甲基菌
<400> 45
Met Thr Asn Asp Val Ser Asn Thr Ser Ser Ile Pro Ala Leu Asn Ala
1 5 10 15
Asp Phe Asn Ile Gly Gly Met Leu Leu Lys Met Gly Lys Ile Thr Pro
20 25 30
Gln Asp Ala Glu Arg Ile Leu Arg Val Gln Lys Glu Arg Gly Val Arg
35 40 45
Phe Gly Glu Ala Ala Glu Ser Leu Gly Leu Val Ser Ser Ala Asp Ile
50 55 60
Asn Tyr Val Leu Ser Lys Gln Phe Ala Tyr Pro Tyr Leu Met Asp Gly
65 70 75 80
Arg Gly Asp Phe Ser Glu Asn Leu Val Ala Ala Tyr Asp Pro Phe Ser
85 90 95
Ile Asn Val Glu Lys Tyr Arg Ala Ile Arg Ser Gln Leu Met Leu Tyr
100 105 110
Trp Phe Ala Gln Gly Lys Lys Ser Leu Ser Phe Ser Ser Val Tyr Asp
115 120 125
Lys Asp Asp Thr Ser Asp Leu Val Ala Asn Leu Gly Val Val Phe Ser
130 135 140
Gln Leu Gly Glu Lys Thr Leu Ile Ile Asp Ala His Leu Asp Ser Pro
145 150 155 160
Arg Gln Asn Arg Ile Phe Asn Ile Lys Ser Thr Ala Gly Leu Ser Asp
165 170 175
Ile Leu Ala Gly Arg Val Thr Asp Tyr Ser Ser Ser Ile Thr Arg Leu
180 185 190
Val Glu Phe Glu His Leu Ser Ile Leu Ser Ser Gly Thr Ile Pro Pro
195 200 205
Asn Pro Arg Glu Leu Leu Gly Arg Gly Phe Leu Lys Gln Phe Ile Thr
210 215 220
Ala Ile Ala Asn Asp Tyr Asp Val Ile Leu Val Asp Ala Pro Ser Phe
225 230 235 240
Val Arg His Ser Glu Pro Leu Ser Val Ala Ser Ala Thr Glu Gly Val
245 250 255
Val Leu Leu Ala Lys Arg His Val Ser Lys Ala Asn Asp Leu Ser Lys
260 265 270
Val Val Asp Gln Leu Ser Lys Ile Arg Val Pro Val Val Gly Thr Val
275 280 285
Leu Thr Glu Asn
290
<210> 46
<211> 299
<212> PRT
<213> 糖原甲基菌
<400> 46
Met Ser Leu Asn Gln Ser Ile Ala Val Ala Ser Thr Gln Leu Arg Arg
1 5 10 15
Tyr Gln His Val Ile Pro Leu Leu Val Gly Leu Leu Phe Leu Phe Val
20 25 30
Pro Thr Tyr Leu Asn Leu Thr Asn Thr Val Trp Gln Met Gln Asp Gln
35 40 45
Ala His Gly Pro Leu Ile Leu Met Val Val Leu Tyr Leu Val Trp Val
50 55 60
Asp Lys Glu Ile Leu Leu Asp Thr Ala Asn Leu Arg Gln Ser Gly Arg
65 70 75 80
Gly Val Gly Leu Leu Leu Phe Leu Phe Gly Leu Leu Val Tyr Ile Ile
85 90 95
Gly Arg Ser Gln Asp Leu Leu Val Phe Asp Val Gly Ser Gln Ile Pro
100 105 110
Val Leu Ala Gly Leu Leu Leu Ile Phe Tyr Lys Ala Lys Thr Leu Lys
115 120 125
Arg Phe Trp Phe Pro Leu Phe Phe Leu Phe Phe Met Ile Pro Leu Pro
130 135 140
Gly Ser Met Leu Asp Val Val Thr Leu Pro Met Lys Val Ala Val Ser
145 150 155 160
Tyr Val Ala Glu His Val Leu Tyr Trp Phe Asp Tyr Pro Ile Ala Arg
165 170 175
Ser Gly Val Ile Ile Gln Ile Gly Gln Tyr Gln Leu Leu Val Ala Asp
180 185 190
Ala Cys Ala Gly Met His Thr Leu Ile Ser Leu Glu Ala Leu Gly Leu
195 200 205
Leu Tyr Leu Asn Ile Val Arg His Asp Ser Leu Ala Arg Asn Leu Leu
210 215 220
Leu Ala Leu Leu Ile Ile Pro Ile Ser Phe Ser Ala Asn Val Ile Arg
225 230 235 240
Val Ile Val Leu Thr Leu Ile Thr Tyr Tyr Phe Gly Asp Glu Val Gly
245 250 255
Gln Gly Phe Val His Gly Phe Ala Gly Ile Leu Leu Phe Val Val Ala
260 265 270
Leu Thr Leu Ile Ile Ser Val Asp Ser Leu Ile Gln Tyr Phe Val Gly
275 280 285
Lys His Thr Gln Arg Lys Ala Arg Leu Gln Ser
290 295
<210> 47
<211> 228
<212> PRT
<213> 糖原甲基菌
<400> 47
Met Ser Val Arg Leu Ile Asn Ile Leu Ala Val Cys Met Val Val Ser
1 5 10 15
Ser Gly Leu Ala Leu Ala Leu Thr Pro Asp Leu Ser Ser Val Arg Asp
20 25 30
Asp Pro His Leu Glu Ser Phe Val Pro Ser Ser Phe Gly Gln Trp Gln
35 40 45
Glu Val Lys Thr Asn Gln Val Gln Met Asp Leu Thr Val Arg Arg Asp
50 55 60
Gly Glu Pro Ser Ile Asp Asn Pro Tyr Asp Glu Val Leu Met Arg Ser
65 70 75 80
Tyr Ala Asn Glu Lys Gly Gln Val Ile Met Leu Ala Leu Ala Tyr Gly
85 90 95
Lys Leu Gln Arg Gln Glu Val Lys Val His Arg Pro Glu Leu Cys Tyr
100 105 110
Thr Ala Gln Gly Phe Ser Ile Arg Asn Gln Gln Asp Thr Ala Val Asn
115 120 125
Val Gly Ala Gly Ala Thr Pro Ile Pro Ser Lys Ala Leu Val Ala Ala
130 135 140
Ser Arg Gln Arg Glu Glu Leu Val Leu Tyr Trp Ile Arg Ile Gly Asp
145 150 155 160
Met Ile Ser Lys Ser Ala Trp Glu Thr Arg Leu Tyr Ile Val Glu Gln
165 170 175
Gly Leu Lys His Gln Leu Val Asp Gly Ile Leu Val Arg Thr Ser Gln
180 185 190
Ile Leu Gly Glu Asp Asp Ala Glu Gln Ser Leu Gln Leu Gln Gln Gln
195 200 205
Phe Leu His Asp Leu Val Gln Ala Val Pro Arg Asp Lys Arg Lys Tyr
210 215 220
Leu Ile Pro Ser
225
<210> 48
<211> 378
<212> PRT
<213> 糖原甲基菌
<400> 48
Met Lys Ile Leu Phe Leu Ser His Thr Ala Ala Gly Gly Glu Phe Val
1 5 10 15
Val Gly Ser His Gln Leu Ser Lys Gln Phe Ala Leu Gln Gly His Glu
20 25 30
Val Val His Leu Ser Pro Pro Val Thr Pro Ala His Leu Thr Leu Leu
35 40 45
Gln Lys Thr Pro Phe Glu Arg Val Arg Phe Lys Arg Trp Met Lys Ala
50 55 60
Gly Asp Val Ile Asn His Val Thr Asp Ile Ile Pro Phe Ser Leu Ile
65 70 75 80
Pro Trp Gly Ile Ala Thr Arg Leu Gly Ser Gly Ser Asp Ile Phe Gly
85 90 95
Tyr Phe Leu Lys Phe Ser Ala Leu Arg Gln Leu Arg Lys His Gln Phe
100 105 110
Ser Asn Pro Asp Val Val Leu Ile Asp Glu Pro Arg Leu Gly Tyr Leu
115 120 125
Leu Lys Tyr Phe Pro Lys Ser Lys Ile Val Tyr Arg Pro Thr Asp Ile
130 135 140
Tyr His Glu Ile Arg Asn Asp Pro Ser Ile Val Asp Ala Glu Lys Gly
145 150 155 160
Leu Ile Ser Gln Val His Gly Phe Ile Ala Thr Ser Glu Pro Val Arg
165 170 175
Gln His Leu Asn Arg Leu Gly Val Asp Glu Val Leu Leu Leu Gln Asn
180 185 190
Gly Val Asp Leu Asp His Tyr Leu Asn Phe Thr Lys Ser Lys Leu Asp
195 200 205
Leu Pro Pro Glu Pro Arg Ala Ile Tyr Ala Gly Ala Leu Asp His Arg
210 215 220
Phe Gly Phe Asp Val Leu Lys Ser Ala Ala Thr Lys His Gln Lys Ile
225 230 235 240
Ser Phe Leu Leu Ala Gly Pro Val Glu Glu Lys Tyr Lys Ala Ala Phe
245 250 255
Ser Asp Leu Ala Asn Val His Phe Leu Gly His Val Gln Tyr Lys Ala
260 265 270
Leu Pro Asn Leu Leu Ser Gln Cys Gln Ile Gly Leu Leu Pro Met Ser
275 280 285
Asp His Pro Ser Asn Leu Gly Arg Ser Pro Met Lys Leu Phe Glu Tyr
290 295 300
Ala Ala Val Gly Leu Pro Val Val Ser Thr Ser Thr Pro Glu Leu Glu
305 310 315 320
Arg Arg Ser Leu Pro Phe Val Phe Leu Ala Glu Asn Ala Gln Ile Phe
325 330 335
Thr Asp Lys Leu Gly Asp Val Cys Asn Ala Asp Ile Lys Ile Leu Ala
340 345 350
Gln Gln Ala Arg Asp Asn Ala Lys His Glu Ser Trp Ala Ser Lys Thr
355 360 365
Ile Thr Ile Leu Asn Tyr Ile Tyr Ser Lys
370 375
<210> 49
<211> 420
<212> PRT
<213> 糖原甲基菌
<400> 49
Met Asn Lys Thr Thr Glu Pro Gln Asp Ser Gln Thr Asn Val Pro Trp
1 5 10 15
Trp Leu Ser Pro His Gly Leu Cys Leu Gly Phe Leu Leu Pro Met Ile
20 25 30
Leu Leu Ile Trp Trp Leu Gly Ser Val Arg Ser Pro Thr Leu Thr Ile
35 40 45
Arg Gly Tyr Ile Tyr Leu Ser Ser Glu Tyr Ile Ala Leu Ala Val Leu
50 55 60
Ile Val Val Leu Ser Ala Ser Ala Ala Trp Met Gly Ser Phe Val Lys
65 70 75 80
Thr Lys Val Arg Val Pro Pro Asp Ser Gln Val Asn Met Ala Leu Arg
85 90 95
Val Leu Gly Tyr Val Ala Val Ala Ala Tyr Ile Tyr Trp Phe Lys Glu
100 105 110
Leu Ile Ile Asn Pro Met Asn Ile Ile Asn Ile Phe Thr Gly Thr Gly
115 120 125
Leu Ser Arg Gln Glu Ile Gly Ala Thr Gln Gly Ile Thr Ser Leu Val
130 135 140
Asn Phe Thr Pro Ile Phe Ile Ser Ile Tyr Ile Tyr Ala Arg Tyr Ile
145 150 155 160
Ala Lys Leu Pro Leu Arg Gln Asp Val Val Leu Leu Phe Tyr Ala Ile
165 170 175
Val Leu Leu Thr Leu Leu Arg Val Phe Ala Trp Ala Glu Arg Leu Ala
180 185 190
Leu Ile Glu Ile Ile Leu Pro Phe Ala Leu Leu Ile Thr Arg Gln Gln
195 200 205
Val Phe Ser Lys Ile Lys Ile Leu Gln Phe Phe Ile Lys Ala Gly Pro
210 215 220
Phe Ala Gly Leu Pro Leu Leu Val Leu Tyr Phe Gly Met Ala Glu Tyr
225 230 235 240
Phe Arg Ser Trp Ser Ser Thr Thr Tyr Ala Gly Lys Ser Ser Phe Trp
245 250 255
Asp Phe Ala Leu Gly Arg Ile Ala Ser Tyr Tyr Tyr Thr Ser Leu Asn
260 265 270
Asn Gly Ala Gly Met Leu Ala Thr Val Asn Trp Pro Thr Tyr Glu Phe
275 280 285
Glu Asn Val Leu Asn Trp Met His Lys Phe Pro Ile Phe Gly Gly Val
290 295 300
Phe Arg Tyr Tyr Val Asp Leu His Thr Met Arg Met Gly Glu Phe Leu
305 310 315 320
Ala Gln Tyr Gly Asp Glu Glu Phe Asn Asn Pro Ser Gly Ile Phe Ser
325 330 335
Val Ile Leu Asp Leu Gly Leu Pro Phe Gly Ile Ile Tyr Phe Phe Ile
340 345 350
Thr Ala Phe Leu Ala Gly Ile Phe Tyr Lys Gly Tyr Leu Arg Gly Asn
355 360 365
Phe Leu Ser Val Ile Phe Tyr Pro Leu Phe Phe Ile Thr Leu Leu Glu
370 375 380
Ile Phe Arg Tyr Pro Tyr Leu Gly Thr Ser Arg Ala Phe Thr Glu Ile
385 390 395 400
Ile Gly Val Ile Ile Ala Phe Phe Ile Val Lys Gly Arg Thr Glu Asn
405 410 415
Asp Arg Lys Ser
420
<210> 50
<211> 454
<212> PRT
<213> 糖原甲基菌
<400> 50
Met Ile Glu Asn Arg Arg His Leu Val Lys Ser Leu Phe Leu Met Leu
1 5 10 15
Phe Ser Ser Trp Leu Pro Lys Val Ala Ser Ala Ala Pro Lys Val Val
20 25 30
Gly Gly Asn Ala Asp Phe Thr Arg Ala Leu Asp Asp Ala Leu Ala Gly
35 40 45
Arg Thr Glu Val Leu Ser Gly Tyr Tyr Glu Ile Ser Asn Pro Leu Arg
50 55 60
Phe Ser Leu Lys Ser Gly Thr Val Lys Phe Ala Pro Asp Phe Gln Leu
65 70 75 80
Lys Phe Leu Asn Asp Lys Leu Ser Gly Leu Val Phe Ser Ser Cys Ser
85 90 95
Asp Leu Ser Leu Ile Gly Gly Asp Phe Ser Tyr Lys Asn Pro Pro Ala
100 105 110
Arg Arg Ile Gly His Gly Gly Ile Tyr Glu Phe Ser Arg Cys Thr Lys
115 120 125
Val Ile Val Arg Asp Gly Phe Tyr Tyr Asp Thr Pro Gly Thr Gly Ile
130 135 140
Ile Phe Thr Leu Cys Asp Asp Cys Ala Val Ile Lys Ala Thr Val Trp
145 150 155 160
Asn Ser Trp Ala Asp Gly Leu His Phe Ala Asn Cys Asn Asn Cys Ile
165 170 175
Ala Leu Asp Tyr Gln Ser Thr Asn Thr Gly Asp Asp Gly Leu Ala Phe
180 185 190
Val Asn Tyr Lys Lys His Pro Asp Ala Val Gly Gly Tyr Ala Asn Asn
195 200 205
Ile Val Ile Asn Gly Ser Tyr Ala Arg Gly Ile Ala Ile Ile Gly Gln
210 215 220
Ser Gly Val Thr Ile Asp Lys Phe Glu Ile Arg His Thr Ser Ala Glu
225 230 235 240
Gly Leu Lys Ile Gly Ser Glu Gln Tyr Tyr Asp Thr Arg Ile Pro Ser
245 250 255
Asn Val Thr Ile Lys Asn Gly Ile Val Glu Glu Ala Gly Thr Trp Cys
260 265 270
Val Ala Lys Ala Thr Gly Asn Gly Phe Leu Val Gln Gly Ala Thr Asp
275 280 285
Lys Ile Val Val Glu Asn Leu Thr Val Asn Ala Pro Arg Val His Gly
290 295 300
Ile Val Phe Asp Arg His Gly Gly Asn Val Lys Met Lys Asp Ile Val
305 310 315 320
Val Lys Asn Thr Lys Ala Ser Gly Ile Thr Met Met Ala Asp Asn Ile
325 330 335
Glu Leu Val Asn Gly Glu Phe Leu Asn Ile Gly Thr Thr Pro Leu Tyr
340 345 350
Val Asn Lys Ala Leu Thr Ala Asn Phe Ser Lys Ile Asn Val Asn Thr
355 360 365
Phe Gly Phe Ala Asp Lys Ser Ser Trp Pro Ile Phe Trp Ala Val Glu
370 375 380
Ala Lys Asn Val Leu Ile Asn Gln Met Lys Val Glu Ser Thr Thr Leu
385 390 395 400
Val Arg Ile Gly Gly Lys Asn Val Ile Ser His Gln Ile Thr Gly Val
405 410 415
Gln Ile Ser Gly Val Gln Leu Ser Gly Leu Leu Ser Asp Gly Leu Asn
420 425 430
Ser Lys Thr Thr Ser Ala Val Ser Ala Ile Thr Ser Thr Ala Val Lys
435 440 445
Phe Ile Glu Gln Trp Asn
450
<210> 51
<211> 368
<212> PRT
<213> 糖原甲基菌
<400> 51
Met Asp Ala Gly Ala Arg Leu Arg Ile Ser Trp Ile Asp Val Cys Arg
1 5 10 15
Gly Phe Ala Met Leu Leu Val Val Val Gly His Asn Gln Ile Leu Met
20 25 30
Gly Gln Ser Leu Ser Leu Val Lys Phe Ile Tyr Leu Phe His Met Pro
35 40 45
Leu Phe Phe Phe Ile Ser Gly Ile Thr Leu Lys Pro Asp Gln Gly Leu
50 55 60
Thr Tyr Tyr Phe Thr Arg Ala Ile Asn Val Ile Ala Val Tyr Phe Val
65 70 75 80
Phe Ser Phe Leu Val Leu Pro Phe Val Leu Met Lys Asn Pro Asp Asp
85 90 95
Gly Val Phe Asn Ile Val Leu Gly Ile Leu Tyr Gly Thr Gly His Thr
100 105 110
Ile Glu Val Ala Pro Leu Trp Phe Ile Pro Cys Leu Phe Phe Ser Ile
115 120 125
Val Leu Val Gly Leu Ala Leu Val Ile Ser Asn His Phe Asn Asn Thr
130 135 140
Asp Arg Glu Ser Asn Arg Ser Pro Ile Phe Phe Leu Ala Leu Leu Phe
145 150 155 160
Ile Gly Val Gly Val Phe Leu Ile Asn Ser Ile His Tyr Tyr Leu Ile
165 170 175
Asp Asn Leu Ala Trp Gly Ser Leu Lys Asn Ser Gly Met Ile Trp Ser
180 185 190
Ile Asp Ile Ala Ile Ile Gly Ala Gly Phe Ile Leu Leu Gly Met Tyr
195 200 205
Ala Lys Val Phe Val Asp Lys Tyr Lys Ile Thr Glu Ile Lys Ser Ile
210 215 220
Tyr Leu Ile Val Ser Ile Val Cys Ala Ile Phe Val Met Leu Gly Leu
225 230 235 240
Phe Ser Phe Gly Val Asp Val Asp Leu Asn Phe Arg Lys Ile Ala His
245 250 255
Tyr Pro Leu Ala Met Leu Cys Met Ile Leu Gly Ile Phe Phe Ser Ile
260 265 270
Leu Phe Ser Ile Phe Leu Asp Lys Tyr Thr Tyr Leu Ser Thr Ile Leu
275 280 285
Ser Ser Ile Gly Lys Ser Thr Leu Leu Ile Leu Leu Phe His Asn Ala
290 295 300
Ile Gln Asn His Leu Ile Phe Thr Ile Gly Asp Ser Lys Ile Tyr Ser
305 310 315 320
Ala Val Ile Gly Ile Val Ile Ala Ile Leu Ile Pro Ile Val Leu Asp
325 330 335
Lys Phe Val Val Asn Lys Tyr Glu Leu Phe Arg Lys Ile Val Tyr Pro
340 345 350
Lys Leu Ser Ile Asn Leu Ala Ser Lys Ile Met Val Gly Lys Arg Phe
355 360 365
<210> 52
<211> 365
<212> PRT
<213> 糖原甲基菌
<400> 52
Met Ile Val Tyr Ile Asn Gly Arg Phe Leu Gly Arg Arg Ile Thr Gly
1 5 10 15
Val Asp Arg Tyr Ala Ile Glu Val Leu Lys Glu Leu Asn Thr Leu Ile
20 25 30
Ala Glu Asn His Pro Ser Val Ala Gly Val Glu Tyr Lys Ile Val Ile
35 40 45
Pro Pro Arg Ile Lys Thr Asp Leu His Leu Thr His Ile Pro Ile Val
50 55 60
Ala Tyr Gly Phe Phe Ser Gly His Ala Trp Glu Gln Leu Ser Leu Leu
65 70 75 80
Met Leu Ser Leu Ser Ser Lys Ser Met Val Leu Asn Leu Cys Asn Thr
85 90 95
Gly Ser Ile Phe Val Arg Ser Gln Ile Val Val Ile His Asp Ala Ala
100 105 110
Val Val Arg Ile Pro Ser Thr Phe Ser Leu Ala Phe Arg Val Trp Tyr
115 120 125
Lys Thr Leu Met Pro Val Leu Gly Arg Val Ala Lys Lys Ile Val Thr
130 135 140
Val Ser Glu Tyr Ser Lys Lys Asp Ile Ile Asn Phe Phe Gly Val His
145 150 155 160
Pro Glu Lys Val Gln Val Val Gly Ala Gly Gly Glu His Ile Leu Ser
165 170 175
Gln Gln Pro Asp Ala Gly Ile Leu Glu Lys Phe Gln Val His Pro Gly
180 185 190
Ser Tyr Val Leu Ala Val Ser Ser His Ala Pro His Lys Asn Phe Ser
195 200 205
Leu Thr Ile Glu Ser Leu Lys Leu Ser Lys Asn Ala Asn Ile Pro Tyr
210 215 220
Leu Ile Ala Gly Gly Ala Asn Gln Lys Ile Phe Gly Glu Asn Ser Gln
225 230 235 240
Leu Asp Ser Ser Lys Val Thr Leu Leu Gly Tyr Val Ser Asp Asn Glu
245 250 255
Leu Arg Ala Leu Tyr Glu His Ala Leu Cys Phe Val Phe Pro Ser Leu
260 265 270
Tyr Glu Gly Phe Gly Leu Pro Pro Leu Glu Ala Met Asn Cys Gly Cys
275 280 285
Pro Val Leu Ala Ser Asn Ala Ala Ser Ile Pro Glu Val Cys Ser Asp
290 295 300
Ala Ala Leu Tyr Phe Ser Pro His Asp Pro Gln Glu Leu Ser Lys Leu
305 310 315 320
Ile Asp Asn Val Ala His Asp Ala Asp Leu Arg Lys Ser Leu Val Asn
325 330 335
Gln Gly Leu Lys Arg Ala Lys Asp Phe Ser Trp Lys Asn Ser Ala Ile
340 345 350
Asp Ile Ala Arg Met Cys Lys Glu Ile Phe Thr Ile Lys
355 360 365
<210> 53
<211> 384
<212> PRT
<213> 糖原甲基菌
<400> 53
Met Thr Asn Lys Tyr Thr Arg His Ser Arg Leu His Pro Lys Lys Val
1 5 10 15
Ala Ile Val Val Asp Trp Leu Asn Glu Tyr Ala Gly Ala Glu Arg Val
20 25 30
Leu Glu Gln Leu Val Leu Cys Tyr Pro Asp Ala Asp Ile Phe Ala Val
35 40 45
Ile Glu Phe Leu Pro Asp Asn Leu Arg Gly Phe Ile Gln Asn Lys Lys
50 55 60
Val Thr Thr Thr Phe Ile Gln Asn Leu Pro Lys Ala Lys Thr His Tyr
65 70 75 80
Arg Asn Tyr Leu Pro Leu Met Pro Leu Ala Ile Glu Gln Leu Asp Leu
85 90 95
Ser Gln Tyr Asp Leu Ile Ile Ser Ser Ser His Ala Val Ala Lys Gly
100 105 110
Val Leu Thr Gly Pro Asp Gln Val His Val Ser Tyr Val His Ser Pro
115 120 125
Met Arg Tyr Ala Trp Asp Leu Gln His Gln Tyr Leu Arg Glu Ser Asn
130 135 140
Leu Val Ser Gly Phe Lys Ser Trp Ile Val Lys Trp Leu Leu His Lys
145 150 155 160
Leu Arg Ile Trp Asp Leu Arg Thr Ala Asn Gly Val Asp Val Phe Ile
165 170 175
Ala Asn Ser Ser Phe Ile Ala Lys Arg Ile Lys Lys Val Tyr Gly Arg
180 185 190
Glu Ala Arg Val Ile Tyr Pro Pro Val Asp Thr Asn Ser Phe Ala Phe
195 200 205
Gln Glu Lys Lys Asp Asp Phe Phe Leu Thr Ala Ser Arg Leu Val Pro
210 215 220
Tyr Lys Arg Val Asp Leu Ile Val Glu Ala Phe Ser Lys Ile Pro Asp
225 230 235 240
Gln Lys Leu Val Val Ile Gly Asp Gly Pro Asp Met Ser Lys Val Arg
245 250 255
Ala Lys Ala Gly Pro Asn Val Glu Ile Leu Gly Tyr Gln Ser His Ala
260 265 270
Val Leu Arg Asp Tyr Met Gln Arg Ala Lys Gly Phe Val Phe Ala Ala
275 280 285
Glu Glu Asp Phe Gly Ile Ser Pro Val Glu Ala Gln Ala Cys Gly Thr
290 295 300
Pro Val Ile Ala Phe Ala Lys Gly Gly Ala Leu Glu Thr Val Ile Pro
305 310 315 320
Glu Glu Arg Gly Asp Pro Ala Thr Gly Leu Phe Phe His Glu Gln Thr
325 330 335
Ala Asp Ala Ile Val Asp Ala Ile Thr Arg Phe Asn Leu Leu Ser Gln
340 345 350
Lys Ile Ser Pro Phe Ala Cys Arg Glu Asn Ala Leu Arg Phe Ser Pro
355 360 365
Asp Arg Phe Arg Asn Glu Ile Ile Ser Thr Val Asn Lys Ala Leu Asp
370 375 380
<210> 54
<211> 388
<212> PRT
<213> 糖原甲基菌
<400> 54
Met Lys Ile Ala Val Ala Gly Thr Gly Tyr Val Gly Leu Ser Ile Ala
1 5 10 15
Val Leu Leu Ala Gln Lys Asn Glu Val Val Ala Leu Asp Ile Val Pro
20 25 30
Asp Lys Val Asp Leu Ile Asn Asn Lys Ile Ser Pro Ile Val Asp Lys
35 40 45
Glu Ile Glu His Tyr Leu Lys Asn Ile Pro Leu Asn Leu Arg Ala Thr
50 55 60
Thr Asn Lys His Asp Ala Tyr Glu Asn Ala Asp Phe Val Val Ile Ala
65 70 75 80
Thr Pro Thr Asp Tyr Asp Pro Val Thr Ser Tyr Phe Asn Thr Ser Ser
85 90 95
Val Glu Ala Val Ile Lys Asp Val Gln Ala Ile Ala Pro Asn Ala Thr
100 105 110
Met Val Ile Lys Ser Thr Ile Pro Val Gly Tyr Thr Lys Met Ile Ser
115 120 125
Glu Lys Leu Gly Val Asp Asn Leu Ile Phe Ser Pro Glu Phe Leu Arg
130 135 140
Glu Gly Lys Ala Leu Tyr Asp Asn Leu Tyr Pro Ser Arg Ile Val Ile
145 150 155 160
Gly Glu Ile Ser Asp Arg Ala Gln Val Phe Ala Asp Leu Leu Asn Ala
165 170 175
Gly Ala Val Lys Glu Asn Ile Pro Val Leu Leu Thr Asn Ser Ala Glu
180 185 190
Ala Glu Ala Ile Lys Leu Phe Ala Asn Thr Phe Leu Ala Met Arg Val
195 200 205
Ala Tyr Phe Asn Glu Leu Asp Thr Tyr Ala Ala Thr His Gly Leu Asn
210 215 220
Thr Arg Gln Ile Ile Asp Gly Val Cys Leu Asp Pro Arg Val Gly Asp
225 230 235 240
His Tyr Asn Asn Pro Ser Phe Gly Tyr Gly Gly Tyr Cys Leu Pro Lys
245 250 255
Asp Thr Lys Gln Leu Leu Ala Asn Tyr Asp Asn Val Pro Gln Lys Leu
260 265 270
Ile Asn Ala Ile Val Asp Ala Asn Thr Thr Arg Lys Asp Phe Ile Ala
275 280 285
Gln Ser Ile Ile Lys Arg Asp Pro Lys Val Val Gly Ile Tyr Arg Leu
290 295 300
Ile Met Lys Ala Gly Ser Asp Asn Phe Arg Ala Ser Ser Ile Gln Gly
305 310 315 320
Val Met Lys Arg Ile Lys Ala Arg Gly Ile Lys Val Val Val Phe Glu
325 330 335
Pro Glu Leu Lys Glu Asp Gln Phe Phe Asn Ser Glu Val Ile Arg Asn
340 345 350
Leu Glu Glu Phe Lys Lys Ile Ser Asp Val Ile Val Ala Asn Arg Arg
355 360 365
Ala Gln Asp Leu Ser Asp Val Asp Glu Lys Val Tyr Thr Arg Asp Leu
370 375 380
Phe Gly Asn Asp
385
<210> 55
<211> 323
<212> PRT
<213> 糖原甲基菌
<400> 55
Met Arg Ile Leu Phe Ser Pro Ala Thr Ala Ser Asn Gln Tyr Val Glu
1 5 10 15
Asn Thr Ile Ala Leu Ile Lys Thr Leu Asp Ala Thr His Val Glu Thr
20 25 30
Gln Ala Arg Leu Asn Ala Gly Phe Ile Leu Arg Asn Ala Phe Asn Arg
35 40 45
Tyr Asp Cys Ile Ile Ile Asn Trp Leu Glu Asn Asn Leu Val Gly Lys
50 55 60
Asn Lys Ser Leu Asp Ile Trp Ala Val Ala Lys Phe Leu Phe Lys Phe
65 70 75 80
Phe Ile Tyr Arg Val Met Gly Arg Lys Leu Ile Phe Val Arg His Asn
85 90 95
Ile Tyr Pro His Ala Leu Lys Gly Arg Gln Ala Ser Ile Ala Thr Trp
100 105 110
Ile Ile Glu Ala Ala Ile Lys Leu Ser Thr Ile Ser Val Val His Ser
115 120 125
Gly His Leu Glu Asn Glu Asn Ala Lys Tyr Val Pro His Pro Leu Tyr
130 135 140
Arg Val Asp Ser Gln Val Glu Gly Gln Gly Ser Asp Tyr Tyr Val Ile
145 150 155 160
Phe Gly Arg Ile Val Ala Tyr Lys Ala Ile His Lys Leu Leu Glu Ser
165 170 175
Trp Gly Ser Gln Arg Leu Ile Ile Ala Gly Ile Val Glu Asp His Ala
180 185 190
Tyr Ala Ala Ser Leu Gln Ser Ile Ile Gln Ser Arg Gly Leu Ser Asn
195 200 205
Val Glu Leu Arg Ala Glu Phe Leu Ser Glu Ala Glu Ala Glu Gln Leu
210 215 220
Val Ala Asn Ser Lys Gly Leu Ile Leu Ser His Cys Asp Ala Asp Met
225 230 235 240
Ile Val Ser Gly Ser Phe Phe Phe Ala Ala Ser Leu Gly Val Pro Val
245 250 255
Phe Ala Met Asp Thr Pro Phe Phe Gln Trp Leu Lys Asn Glu Gln Gly
260 265 270
Tyr Gln Gly Leu Gln Val Phe Thr Ser Leu Gln Ala Met Thr Ala Glu
275 280 285
Leu Ala Thr Ala Ala Ala Val Glu Lys Asn Thr Ile Ala Ala Ser Ala
290 295 300
Gln Arg Leu Phe Gly Asn Asp Arg Val Arg Ser Ala Trp Gly Ser Val
305 310 315 320
Leu His Gly
<210> 56
<211> 470
<212> PRT
<213> 糖原甲基菌
<400> 56
Met Thr Thr Ile Gly Gln Asp Val Asn Gln Pro Ala Gly Ile Pro Glu
1 5 10 15
Val Phe Thr Ile Asn Asp Val Val Asp Arg Gly Leu Cys Val Gly Cys
20 25 30
Gly Ala Cys Ala Val Val Asp Ser Asn Val Lys Leu Thr Arg Asn Gln
35 40 45
Tyr Gly Ser Met Val Ala Ala Ile Asp Ala Asn Ile Leu Pro Gly Ser
50 55 60
Ile Ala Asp Arg Val Cys Pro Phe Ser Asp Asn Ser Leu Asn Glu Asp
65 70 75 80
Val Val Gly Glu Arg Val Phe Ala Ser Cys Glu Asn Phe Asp Gln Arg
85 90 95
Thr Gly Tyr Tyr Thr Asn Leu Tyr Tyr Gly Arg Arg Phe Thr Glu Ala
100 105 110
Glu Leu Leu Lys Ser Ser Ser Gly Gly Leu Thr Ser Tyr Val Ala Ile
115 120 125
Glu Leu Leu Lys Arg His His Val Asp Gly Ile Ile His Val Gly Arg
130 135 140
Asp Gln Ser Asp Asp Arg Asp Ala Leu Phe Lys Phe Met Val Ser Tyr
145 150 155 160
Thr Glu Glu Asp Ala Asn Ala Cys Lys Lys Ser Gln Tyr Tyr Ser Leu
165 170 175
Ser Phe Asp Glu Val Val Arg Ser Ile Arg Gly Asp Gly Lys Arg Tyr
180 185 190
Val Phe Val Gly Val Pro Cys Phe Val Lys Ser Leu Arg Asn Ile Cys
195 200 205
Leu Asn Asp Ala Val Leu Asn Glu Gln Ile Pro Phe Met Leu Gly Leu
210 215 220
Val Cys Gly His Leu Lys Ser Ser Arg Phe Ala Glu Leu Leu Ala Trp
225 230 235 240
Gln Leu Ser Val Pro Pro Glu Lys Ile Gln Ser Val Asp Phe Arg Val
245 250 255
Lys Asn Asn Ala Ser Thr Val Asn Ser Tyr Asp Phe Gln Val Val Asp
260 265 270
Ser Asn Gln Gln Ala His Ala Lys Thr Ser Asn Thr Met Leu Gly Gly
275 280 285
Asn Trp Gly His Ala Ala Phe Gln Leu Gln Ala Cys Asp Tyr Cys Asp
290 295 300
Asp Ile Phe Ala Glu Thr Ala Asp Ala Val Phe Gly Asp Ala Trp Leu
305 310 315 320
Pro Gln Phe Ser Thr Trp Trp Gln Gly Thr Asn Ile Val Leu Val Arg
325 330 335
Asn Pro Ile Ile Asp Asp Ile Leu Glu Ser Gly Lys Asn Ala Gly Ala
340 345 350
Ile Thr Leu Gly Gly Val Ser Ile Asp Asp Leu Cys Lys Ser Gln Leu
355 360 365
Gly Asn Phe Arg His Arg Lys Asp Gly Leu Ile Val Arg Leu Asp Asp
370 375 380
Asp Leu Lys Gln Gly Lys Lys Val Pro Lys Lys Arg Val Asp Leu Ser
385 390 395 400
Ala Leu Gly Lys Ile Asp Gln Lys Arg Lys Lys Ile Val Arg Leu Arg
405 410 415
Lys Glu Met Ala Val Lys Ser His Glu Tyr Phe Leu Gln Ala Arg Glu
420 425 430
Lys His Asp Leu Ser Leu Tyr Met Lys Pro Met Gly Gln Leu Ala Arg
435 440 445
Asn Met Leu Lys Leu Tyr Arg Asp Pro Phe Met Lys Arg Leu Ile Asn
450 455 460
Arg Leu Lys Arg Tyr Phe
465 470
<210> 57
<211> 482
<212> PRT
<213> 糖原甲基菌
<400> 57
Met Ser Leu Ser Val Lys Ala Ala Arg Gly Gly Val Val Met Met Ser
1 5 10 15
Gly Gln Ile Val Lys Val Ala Leu Gln Phe Gly Ser Leu Ile Ile Leu
20 25 30
Ala Arg Leu Leu Gln Pro Glu Asp Phe Gly Leu Val Ala Met Val Ile
35 40 45
Ala Ile Tyr Gly Ile Cys Asp Ile Leu Leu Asp Phe Gly Leu Ser Thr
50 55 60
Ala Ser Ile Gln Val Gln Asn Ile Thr Lys Ala Gln Ile Ser Asn Leu
65 70 75 80
Phe Trp Val Asn Val Leu Ile Gly Leu Leu Phe Thr Leu Ile Ser Tyr
85 90 95
Phe Ser Ala Ser Leu Leu Ala Ser Phe Tyr Ala Gln Pro Glu Leu Thr
100 105 110
Lys Ile Ala Gln Tyr Val Ser Val Val Phe Leu Phe Asn Gly Ile Ala
115 120 125
Ala Gln Tyr Lys Ala Gln Leu Asn Arg Asn Phe Lys Phe Lys Gln Met
130 135 140
Ala Ile Thr Asp Thr Thr Ala Val Leu Leu Ser Val Cys Ile Gly Val
145 150 155 160
Tyr Phe Ala Tyr Ala Gly His Ser Tyr Trp Ala Ile Val Tyr Gln Gln
165 170 175
Ile Ala Gln Ala Leu Ile Gln Met Leu Leu Tyr Met Leu Phe Gly Ala
180 185 190
Trp Leu Pro Ser Leu Pro Ser Arg His Val Ser Ile Arg His Phe Phe
195 200 205
Lys Phe Gly Trp Gly Leu Ala Gly Ser Gln Leu Met Gly Tyr Phe Ser
210 215 220
Arg Asn Ile Pro Ala Ile Leu Ile Gly Asn Gln Ile Gly Ala Ser Gln
225 230 235 240
Leu Gly Phe Tyr Asp Arg Ala Asn Lys Leu Leu Met Leu Pro Leu Asn
245 250 255
Gln Leu Asn Ala Pro Ser Ser Ser Val Ala Val Pro Val Leu Ser Arg
260 265 270
Leu Ala Val Glu Asp Gln Glu Lys Tyr Asn Arg Phe Leu Leu Phe Gly
275 280 285
Gln Asn Ile Ile Val His Leu Val Val Phe Cys Leu Ala Leu Thr Cys
290 295 300
Cys Gln Thr Glu Arg Leu Val Gln Leu Val Leu Gly Thr Gln Trp Leu
305 310 315 320
Glu Met Val Pro Val Tyr Arg Ala Leu Ser Phe Ala Gly Ile Phe Leu
325 330 335
Ala Leu Ser Tyr Ala Ser Tyr Trp Val Phe Leu Ser Lys Gly Ile Thr
340 345 350
Ala Ser Leu Phe Lys Leu Gly Leu Val Ser Arg Pro Ile Ser Ile Leu
355 360 365
Ile Ile Cys Leu Gly Leu Pro Ala Gly Val Ile Gly Val Ala Tyr Ala
370 375 380
Tyr Ser Ala Ser Leu Leu Phe Thr Trp Leu Leu Gly Val Phe Trp Leu
385 390 395 400
Arg Lys Thr Gly Val Pro Val Lys Ser Met Ile Val Asp Pro Leu Ile
405 410 415
Met Ser Ala Ile Tyr Tyr Ser Ala Ser Phe Ile Ala Asn Tyr Val Val
420 425 430
Asp His Tyr Val Asp Phe Ala Ile Tyr Asn Ile Leu Val Gly Trp Leu
435 440 445
Leu Met Leu Leu Ile Leu Ala Val Phe Tyr Leu Leu Val Pro Lys Phe
450 455 460
Lys Arg Ser Val Lys Lys Leu Phe Glu Val Lys Ser Tyr Ile Arg Asn
465 470 475 480
Lys Gln
<210> 58
<211> 401
<212> PRT
<213> 糖原甲基菌
<400> 58
Met Lys Thr Ile Lys Lys Leu Leu Tyr Lys Ile Leu Gly Ser Ala Gly
1 5 10 15
Ile Lys Ala Lys Ala Ala Ala Val Ile Asn Leu Leu Phe Gly Arg Val
20 25 30
Ala Arg Ser Thr Asn Asp Ser Val Ser Ile Leu Ile Pro Ala Pro Gly
35 40 45
Gly Gly Asn Ile Gly Asp Gln Ala Met Leu Glu Ser Phe Leu His Asn
50 55 60
Ile Asp Gly Lys Lys Leu Ile Ile Lys Thr Gln Pro Ile Ala Leu Asp
65 70 75 80
Ile Pro Ser His Tyr Ala Val Asn Val Glu Val Ile Glu Met Pro Gly
85 90 95
Leu Ile Tyr Gly His Leu Phe Arg Phe Leu Arg Asp Tyr Val Arg Leu
100 105 110
Arg Lys Ile Met Ala Ser Ala Ser Ala Leu Tyr Val Val Gly Ala Asp
115 120 125
Ile Met Asp Gly Gly Tyr Asn Lys Asn Ala Ser Ile Met Arg Ser Lys
130 135 140
Ile Ala Thr Tyr Phe Ala Arg Asn Asn Ile Pro Ser Arg Val Phe Gly
145 150 155 160
Phe Ser Trp Asn Gly Asn Pro Asp Ala Ala Ala Leu Ser Ala Ile Arg
165 170 175
Asn Ala Ala Ala Asn Gly Val Leu Leu Cys Ala Arg Asp Pro Leu Ser
180 185 190
Phe Gln Arg Leu Gln Asp Ala Gly Val Pro Asn Ile Arg Leu Val Ala
195 200 205
Asp Met Val Phe Ala Asn Asp Asn Thr Lys Ser Ala Gly Ile Glu Asp
210 215 220
Ile Leu Gln Phe Cys Ala Gly Lys Gln Ile Ala Leu Val Asn Ala Ser
225 230 235 240
Gly Leu Ile Gly Lys Asn Ile Asp Gln Ile Asp Glu Tyr Ser Lys Val
245 250 255
Ile Asn Lys Leu Met Asp His Asn Phe Asn Ile Val Leu Leu Pro His
260 265 270
Val Ile Arg His Gly Ala Asn Asp Leu Pro Ile Cys Gln Ala Leu Ser
275 280 285
Gly Lys Tyr Pro Asn Ala Phe Leu Val Asn Arg Leu Leu Glu Pro Asp
290 295 300
Gln Val Lys Arg Leu Ala Gln Glu Ala Lys Ile Val Val Thr Gly Arg
305 310 315 320
Met His Leu Ser Ile Met Ser Leu Asn Gln Asn Val Pro Ser Ile Val
325 330 335
Leu Ser Thr Gln Gly Lys Val Asp Gly Leu Met Gln Phe Phe Glu Thr
340 345 350
Glu Lys Leu Ser Ile Asn Pro Glu Lys Gly Phe Ser Asp Leu Ile Cys
355 360 365
Ser Gln Ile Asp Phe Ile Cys Ser Asn Arg Gln Tyr Tyr Gln Asp Leu
370 375 380
Ile Arg Lys Asn Leu Leu Lys Val Lys Glu Leu Ala Ala Gly Asn Phe
385 390 395 400
Asn
<210> 59
<211> 395
<212> PRT
<213> 糖原甲基菌
<400> 59
Met Ser Lys Phe Tyr Lys Phe Gln Val Leu Glu Ser Leu Arg Gly Tyr
1 5 10 15
Met Ala Trp Trp Val Val Leu Gly His Ala Ile Gln Leu Ser Gly Phe
20 25 30
Trp His Lys Gln Glu Val Asp Glu Phe Phe Thr Gly Gly Gly Ile Ile
35 40 45
Asn Ala Thr Phe Ser Lys Ile Leu Ser Leu Ile Ile Asn Pro Glu Leu
50 55 60
Ala Val Asn Ile Phe Ile Ile Leu Ser Gly Phe Val Ile Thr His Leu
65 70 75 80
Leu Leu Thr Lys Asn Glu Pro Tyr Ser His Phe Ile Thr Arg Arg Phe
85 90 95
Phe Arg Leu Ala Pro Ala Phe Tyr Val Ser Leu Val Ile Ala Ile Leu
100 105 110
Val Val Asn Phe Tyr Lys Val Ala Tyr Thr Gly Leu Ser Phe Ser Gly
115 120 125
Asp Thr Ser Met Arg Leu Ala Arg Leu Val Glu Gln Asp Ser Asn Phe
130 135 140
Leu Leu His Leu Phe Asn His Leu Leu Leu Ile His Ser Val Phe Pro
145 150 155 160
Gln Glu Leu Ile Gln Phe Ser Pro Thr Thr Phe Leu Ala Pro Ala Trp
165 170 175
Ser Ile Ser Leu Glu Trp Gln Phe Tyr Leu Ile Ala Pro Val Leu Ile
180 185 190
Pro Phe Leu Val Lys Ser Glu Lys Ser Leu Ile Val Trp Val Val Leu
195 200 205
Leu Leu Leu Leu Arg Tyr Phe Thr Asn His Val Leu Asp Phe Asn Trp
210 215 220
Gln His Ser Ser Phe Phe Phe Lys Ala Val Asp Tyr Phe Leu Val Gly
225 230 235 240
Ile Leu Ser Arg Leu Ile Ile Glu Arg Leu Gln His Gly Lys Phe Ile
245 250 255
Tyr Asp Val Ala Val Leu Leu Gly Gly Ile Leu Leu Phe Gln Asp Arg
260 265 270
Tyr Cys Ala Val Ile Trp Leu Phe Val Leu Ala Val Ile Phe Tyr Glu
275 280 285
Met Gly Tyr Trp Ser Val Lys Ser Pro Leu Trp Lys Lys Ile Leu Thr
290 295 300
Leu Phe Phe Tyr Asn Lys Val Ile Thr Asn Ile Gly Lys Trp Ser Tyr
305 310 315 320
Ser Thr Tyr Leu Ile His Ile Pro Ile Phe Ser Ile Phe Leu Gly Gly
325 330 335
Tyr Ala Thr Leu Thr Asp Pro Gly Thr Val Thr Gln Gln Ile Ser Leu
340 345 350
Ile Ile Leu Phe Val Ser Phe Pro Val Val Leu Leu Ile Ser Asn Ile
355 360 365
Met Tyr His Asn Ile Glu Leu Pro Ser Met Asn Tyr Ile Ser Ala Lys
370 375 380
Leu Lys Glu Lys Arg Ile Thr Glu Ser Ala Glu
385 390 395
<210> 60
<211> 468
<212> PRT
<213> 糖原甲基菌
<400> 60
Met Lys Ile Val Pro Val Leu Leu Ser Gly Gly Ser Gly Thr Arg Leu
1 5 10 15
Trp Pro Leu Ser Arg Ala Val Leu Pro Lys Gln Leu Leu Pro Leu Ile
20 25 30
Thr Asn Lys Thr Met Leu Gln Glu Thr Leu Leu Arg Ile Ser Arg Trp
35 40 45
Ala Thr Val Thr Asn Pro Val Val Val Cys Gly Asn Asp His Arg Phe
50 55 60
Leu Val Ala Glu Gln Leu Arg Glu Ile Ala Leu Ser Pro Asn Ser Ile
65 70 75 80
Ile Leu Glu Pro Ala Pro Lys Asn Thr Ala Pro Ala Ile Ala Ala Ala
85 90 95
Ala Leu Gln Leu Gln Gly Gln Asp Val Tyr Met Leu Val Leu Pro Ala
100 105 110
Asp His Val Ile Arg Asp Leu Gln Ser Phe Glu His Ala Val Gln Thr
115 120 125
Ala Leu Thr Ala Ala Asp Gln Gly Asn Leu Val Thr Phe Gly Ile Lys
130 135 140
Pro Ala His Pro Glu Thr Gly Tyr Gly Tyr Ile Lys Leu Gly Val Glu
145 150 155 160
Ser Ala Pro Gly Ser Tyr Lys Val Asn Arg Phe Val Glu Lys Pro Asp
165 170 175
Leu Ala Thr Ala Thr Glu Tyr Val Ala Ser Gly Glu Phe Phe Trp Asn
180 185 190
Ser Gly Met Phe Leu Phe Lys Pro Glu Thr Phe Leu Lys Gln Leu Glu
195 200 205
Ile His Ala Pro Glu Ile Thr Ala Ala Val Ser Lys Ala Val Asn Asn
210 215 220
Ser Tyr Lys Asp Leu Asp Phe Val Arg Leu Glu Glu Ser Ser Phe Ala
225 230 235 240
Glu Ser Pro Ser Leu Ser Ile Asp Tyr Ala Val Met Glu Lys Thr Asp
245 250 255
His Ala Val Val Val Pro Ala Asp Ile Gly Trp Ser Asp Val Gly Ser
260 265 270
Trp Thr Ser Leu Gln Glu Val Gln Glu Gln Asp Ala Asn Gly Asn Val
275 280 285
Ala Arg Gly Asp Val Tyr Leu Lys Asn Val Glu Asn Ser Leu Val Arg
290 295 300
Ser Glu Asp Arg Phe Val Ala Ala Ile Gly Val Arg Asp Leu Ile Val
305 310 315 320
Val Glu Thr Ser Asp Ala Val Leu Val Ala Ser Lys Asp Ala Ala Gln
325 330 335
Asp Val Lys Glu Val Val Glu Tyr Leu Lys Leu Asn Gln Arg Ser Glu
340 345 350
His Lys Ile His Pro Arg Ala Tyr Arg Pro Trp Gly Trp Tyr Glu Ser
355 360 365
Ile Asp Leu Gly Glu Arg His Gln Val Lys Arg Ile Met Val Lys Pro
370 375 380
Gly Glu Lys Leu Ser Leu Gln Met His His His Arg Ala Glu His Trp
385 390 395 400
Val Val Val Ser Gly Ser Ala Met Ile Thr Val Asp Gly Asn Thr Lys
405 410 415
Leu Phe Ser Glu Asn Gln Ser Thr Tyr Ile Pro Ile Gly Ser Thr His
420 425 430
Arg Leu Glu Asn Pro Gly Lys Leu Pro Leu His Leu Ile Glu Val Gln
435 440 445
Ser Gly Ser Tyr Leu Gly Glu Asp Asp Ile Val Arg Tyr Glu Asp Thr
450 455 460
Tyr Gly Arg Ser
465
<210> 61
<211> 110
<212> PRT
<213> 糖原甲基菌
<400> 61
Met Leu Thr Asp Glu Tyr Arg Tyr Lys Ile Leu Lys Leu Val Gln Glu
1 5 10 15
Lys Pro Asp Ile Ser Gln Arg Glu Leu Ala Lys Ala Leu Gly Ile Ser
20 25 30
Leu Gly Lys Thr Asn Phe Cys Leu Lys Ala Leu Ala Gln Val Gly Leu
35 40 45
Leu Lys Val Ser Asn Phe Arg Asn Ser Lys Asn Lys Leu Ala Tyr Met
50 55 60
Tyr Val Leu Thr Pro Thr Gly Ile Glu His Lys Ala Ala Val Thr Leu
65 70 75 80
Asn Phe Leu Lys Leu Lys Leu Lys Glu Tyr Glu Gln Leu Ala Gly Glu
85 90 95
Ile Glu Glu Leu Arg Ser Glu Ile Asn Ala Lys Val Asn Asp
100 105 110
<210> 62
<211> 362
<212> PRT
<213> 糖原甲基菌
<400> 62
Met Leu Lys Lys Val Ala Leu Ile Thr Gly Ile Thr Gly Gln Asp Gly
1 5 10 15
Ala Tyr Leu Ala Glu Phe Leu Leu Gly Lys Gly Tyr Val Val His Gly
20 25 30
Ile Lys Arg Arg Ala Ser Leu Phe Asn Thr Asp Arg Ile Asp His Leu
35 40 45
Tyr Gln Asp Pro His Val Asp Asn Gln Asn Phe Ile Leu His Tyr Gly
50 55 60
Asp Leu Thr Asp Ser Thr Asn Leu Ile Arg Ile Ile Gln Gln Val Gln
65 70 75 80
Pro Asp Glu Ile Tyr Asn Leu Ala Ala Met Ser His Val Ala Val Ser
85 90 95
Phe Glu Ser Pro Glu Tyr Thr Ala Asn Ala Asp Gly Leu Gly Thr Leu
100 105 110
Arg Ile Leu Glu Ala Ile Arg Ile Leu Gly Leu Glu Lys Lys Thr Arg
115 120 125
Phe Tyr Gln Ala Ser Thr Ser Glu Leu Tyr Gly Leu Val Gln Glu Thr
130 135 140
Pro Gln Lys Glu Ser Thr Pro Phe Tyr Pro Arg Ser Pro Tyr Ala Val
145 150 155 160
Ala Lys Leu Tyr Ala Tyr Trp Ile Thr Val Asn Tyr Arg Glu Ala Tyr
165 170 175
Gly Ile Tyr Ala Cys Asn Gly Ile Leu Phe Asn His Glu Ser Pro Leu
180 185 190
Arg Gly Glu Thr Phe Val Thr Arg Lys Ile Thr Arg Ala Leu Ala Arg
195 200 205
Ile Lys Leu Gly Leu Gln Asp Cys Leu Tyr Leu Gly Asn Leu Asp Ala
210 215 220
Leu Arg Asp Trp Gly His Ala Lys Asp Tyr Val Glu Met Gln Trp Leu
225 230 235 240
Met Leu Gln Gln Glu Gln Ala Glu Asp Phe Val Ile Ala Thr Gly Val
245 250 255
Gln Tyr Ser Val Arg Asp Phe Val Asn Ala Ala Ala His Glu Leu Asp
260 265 270
Ile Ala Ile Thr Trp Lys Gly Gln Gly Gln Glu Glu Met Gly Tyr Asp
275 280 285
Gly Gln Gly Arg Cys Ile Val Gln Val Asp Pro Arg Tyr Phe Arg Pro
290 295 300
Thr Glu Val Glu Thr Leu Leu Gly Asp Pro Ser Lys Ala Lys Gln Lys
305 310 315 320
Leu Gly Trp Ser Pro Ser Ile Ser Phe Gln Glu Leu Val Ser Glu Met
325 330 335
Val Arg Glu Asp Leu Lys Ser Ala Glu Arg Asp Glu Leu Val Lys Gln
340 345 350
His Gly Phe Ala Ala Tyr Asp Tyr Asn Glu
355 360
<210> 63
<211> 313
<212> PRT
<213> 糖原甲基菌
<400> 63
Met Asp Lys His Ala Arg Ile Tyr Val Ala Gly His Arg Gly Leu Val
1 5 10 15
Gly Ser Ala Ile Val Arg Gly Leu Glu Gly Lys Gly Tyr Ser Asn Leu
20 25 30
Ile Lys Arg Thr His Ala Glu Leu Asp Leu Thr Asp Ala Asn Ala Thr
35 40 45
Glu Ala Phe Phe Ala Gln Tyr Gln Pro Asn Met Phe Ser Trp Arg Gln
50 55 60
Pro Lys Trp Val Ala Trp Pro Ile Thr Leu Thr Arg Gln Ile Leu Ser
65 70 75 80
Val Thr Ile Ser Gln Phe Arg Thr Val Ser Ile Val Pro Gly Ser Met
85 90 95
Glu Ser Ala Tyr Cys Phe Gly Pro Ala Ala Tyr Thr Pro Ser Met Leu
100 105 110
Leu Ser Pro Cys Met Ser Thr Thr Phe Pro Asp Arg Leu Lys Leu Pro
115 120 125
Ile Val His Thr Arg Trp Gln Arg Leu Leu Glu Ser Lys Cys Ala Gly
130 135 140
Val Ile Thr Gly Ser Met Ala Leu Asp Phe Leu Gln Gln Cys Arg Gln
145 150 155 160
Ile Phe Met Gly Leu Ala Ile Thr Ile Thr Cys Arg Ile Val Thr Leu
165 170 175
Ser Leu His Tyr Ala Asn Ser Thr Arg Leu Asn Lys Leu Gly Met Gln
180 185 190
Leu Tyr Arg Ser Gly Val Leu Glu His Pro Gly Ala Asn Phe Phe Thr
195 200 205
Val Arg Ile Trp Gln Met Pro Val Tyr Ser Cys Ile Cys Leu Arg Arg
210 215 220
Asn Ser Ile Leu Cys Trp Glu Val Met Arg Val Leu Leu Val Cys Leu
225 230 235 240
Ile His His Ser Ile Ser Val Leu Glu Ser Ile Phe Gln Tyr Arg Asn
245 250 255
Trp Pro Asn Trp Lys Arg Trp Leu Val Thr Lys Glu Gln Leu Ser Ser
260 265 270
Ile Val Gln Asn Leu Met Ala Arg Cys Val Ser Leu Trp Met Ala Ser
275 280 285
Ser Thr Val Trp Gly Gly Leu Ile Pro Leu Ser Leu Met Met Asp Trp
290 295 300
Lys Arg His Ile Arg Asn Phe Gln Asn
305 310
<210> 64
<211> 231
<212> PRT
<213> 糖原甲基菌
<400> 64
Met Lys Lys Lys Val Phe Ala Leu Ile Pro Ala Arg Ala Gly Ser Lys
1 5 10 15
Gly Val Pro Lys Lys Asn Leu Lys Asn Ile Ala Gly Ser Pro Leu Ile
20 25 30
Ala Tyr Thr Ile Asn Ala Ala Lys Lys Ala Lys Asn Val Asp Ala Val
35 40 45
Tyr Val Ser Ser Asp Cys Lys Glu Ile Leu Glu Tyr Ser Lys Ala Gln
50 55 60
Gly Cys Ser Ser Ile Leu Arg Pro Gln Glu Tyr Ala Thr Asp Asp Ala
65 70 75 80
Ser Ala Val Asp Val Val Lys His Phe Ile Ser Ile Glu Asn Ile Glu
85 90 95
Asp Gly Asp Leu Ile Val Tyr Leu Gln Pro Thr Ser Pro Leu Arg Asp
100 105 110
Glu His His Ile Asp Asp Ala Leu Thr Ala Leu Asn Asn Asn Gly Leu
115 120 125
Thr Ser Leu Val Ser Val Glu Val Leu Asp Lys Ser Pro Tyr Lys Ser
130 135 140
Phe Arg Leu Asp Asp Asn Asp Lys Leu Ile Ser Leu Phe Asp Glu Lys
145 150 155 160
Leu Ser Asn Tyr Arg Arg Gln Asp Leu Pro Leu Cys Tyr Ala Pro Asn
165 170 175
Gly Ala Ile Tyr Ile Phe Ser Lys Phe Glu Phe Glu Ala Arg Gly Gly
180 185 190
Phe Pro Ser Asn Gly Ser Val Ala Tyr Ile Met Ser Ala Glu Glu Ser
195 200 205
Val Asp Ile Asp Thr Glu Glu Asp Phe Leu Glu Thr Glu Ala Leu Leu
210 215 220
Arg Lys Lys Tyr Gly Ile Phe
225 230
<210> 65
<211> 346
<212> PRT
<213> 糖原甲基菌
<400> 65
Met Ala Ser Phe Glu Ile Ser Gly Arg Lys Ile Gly Asp Gly His Glu
1 5 10 15
Pro Ile Val Ile Ala Glu Ile Gly Ile Asn His Glu Gly Ser Leu Asp
20 25 30
Leu Ala Ile Asp Met Ala Lys Ala Ala Ile Asp Ala Gly Ala Glu Ile
35 40 45
Ile Lys His Gln Thr His Val Val Glu Asp Glu Met Ser Asp Glu Ala
50 55 60
Lys Ser Val Ile Pro Gly Asn Ala Asp Val Ser Ile Tyr Glu Ile Met
65 70 75 80
Gln Arg Cys Ser Leu Ser Glu Asp Asp Glu Tyr Lys Leu Met Gln Tyr
85 90 95
Val Gln Gln Gln Gly Ser Ile Phe Ile Ser Thr Pro Phe Ser Arg Met
100 105 110
Ala Ala Asn Arg Leu Arg Lys Phe Asp Ile Pro Ala Tyr Lys Ile Gly
115 120 125
Ser Gly Glu Cys Asn Asn Tyr Pro Leu Val Arg His Ile Ala Ser Phe
130 135 140
Gly Lys Pro Ile Ile Val Ser Thr Gly Met Asn Ser Ile Glu Ser Ile
145 150 155 160
Ala Pro Thr Val Asn Ile Leu Arg Gln Ala Lys Val Pro Phe Ala Leu
165 170 175
Leu His Cys Thr Asn Ile Tyr Pro Thr Pro Pro Glu Leu Val Arg Leu
180 185 190
Asp Ala Ile Gln Val Ile Lys Asn Ala Tyr Pro Asp Ala Val Val Gly
195 200 205
Leu Ser Asp His Thr Leu Gly Asn Tyr Ala Cys Leu Gly Ala Val Ala
210 215 220
Leu Gly Ala Ser Ile Leu Glu Arg His Phe Thr Asp Ser Met Ser Arg
225 230 235 240
Pro Gly Pro Asp Ile Val Cys Ser Met Asp Pro Ala Ala Leu Gln Asp
245 250 255
Leu Ile Thr Gly Ser Lys Val Ile Phe Ser Ala Lys Gly Ala His Lys
260 265 270
Gly Pro Leu Leu Glu Glu Glu Lys Thr Ile Ala Phe Ala Phe Ala Ser
275 280 285
Val Val Ala Ile Lys Asp Ile Asn Val Gly Asp Val Leu Ser Glu Asp
290 295 300
Asn Ile Trp Leu Arg Arg Pro Gly Gly Gly Asp Phe Asn Ala Ser Asp
305 310 315 320
Tyr Asp Gln Leu Leu Gly Arg Lys Ala Ser Gln Thr Ile Leu Ser Gly
325 330 335
Lys Arg Val Asn Arg Gln Asp Ile Glu Ala
340 345
<210> 66
<211> 363
<212> PRT
<213> 糖原甲基菌
<400> 66
Met Ser Arg Arg Val Val Phe Leu Thr Gly Thr Arg Ala Asp Phe Gly
1 5 10 15
Lys Leu Lys Ser Leu Met Arg Ala Leu Gln Asn Asp Met Gly Phe Asp
20 25 30
Val His Val Phe Ile Thr Gly Met His Met Leu Ser Lys Tyr Gly Tyr
35 40 45
Thr Cys Glu Glu Val Glu Lys Ala Gly Phe Lys Asn Leu Phe Arg Phe
50 55 60
Ile Asn Gln Asn Gln Ser Asp Ser Met Asp His Ile Leu Ala Lys Thr
65 70 75 80
Ile Thr Gly Leu Ser Asp Tyr Val Lys Glu Ile Ser Pro Glu Leu Ile
85 90 95
Val Ile His Gly Asp Arg Val Glu Ala Leu Ala Gly Ala Ala Val Gly
100 105 110
Ala Leu Asn Asn Ile Arg Val Ala His Ile Glu Gly Gly Glu Val Ser
115 120 125
Gly Thr Val Asp Glu Leu Ile Arg His Ala Val Thr Lys Leu Ser His
130 135 140
Gly His Phe Val Ser Asn Glu Gln Ala Lys Asn Arg Leu Ile Gln Leu
145 150 155 160
Gly Glu Ser Glu Glu Ser Ile Phe Val Ile Gly Ser Pro Asp Ile Asp
165 170 175
Val Met Asn Ser Thr Ser Leu Pro Ser Ile Asp Asp Val Arg Glu Arg
180 185 190
Tyr Gly Phe Ser Phe Glu His Tyr Gly Ile Leu Met Tyr His Pro Val
195 200 205
Thr Ser Glu Leu Asp Asp Leu Pro Arg Gln Ala Lys Ala Ile Val Asp
210 215 220
Tyr Ile Ser Glu Ser Ser Leu Pro Phe Ile Val Val Tyr Pro Asn Asn
225 230 235 240
Asp His Gly Ser Asp Ile Ile Leu Asn Glu Tyr Leu Arg Leu Lys Asn
245 250 255
Leu Ser His Val Arg Val Tyr Pro Ser Ile Arg Phe Glu Tyr Phe Leu
260 265 270
Thr Leu Leu Lys Lys Cys Ser Val His His Gly Leu Arg Trp Ser Lys
275 280 285
Arg Gly Ser Ser Phe Arg Arg Ala Ser His Gln Cys Trp Gln Ala Thr
290 295 300
Gln Ser Asn Ser Arg Val Asp Ser Tyr Tyr Cys Thr Cys Gly Phe Pro
305 310 315 320
Thr Cys Cys Ser Thr Ser Cys Arg His Ser Ser Arg Gly Ser Phe Leu
325 330 335
Trp Trp Cys Arg Val Ser Ser Asp Ser Val Glu Cys Phe Leu Gly Gly
340 345 350
His Thr Lys Ala Leu Tyr Arg Glu Cys Ser Val
355 360
<210> 67
<211> 245
<212> PRT
<213> 糖原甲基菌
<400> 67
Met Arg Leu Ile Ala Arg Leu Asp Val Lys Asn Glu His Val Ile Lys
1 5 10 15
Gly Ile His Leu Glu Gly Leu Arg Lys Val Gly Asp Pro Ile Glu Met
20 25 30
Ala Lys Asn Tyr Tyr Ala Gln Gly Ile Asp Glu Ile Val Phe Ile Asp
35 40 45
Ala Val Ala Ser Leu Tyr Asn Arg Asn Asn Leu Leu Ser Val Ile Ala
50 55 60
Lys Ala Ser Glu Glu Val Phe Val Pro Ile Thr Val Gly Gly Gly Leu
65 70 75 80
Arg Ser Leu Ala Asp Val Glu Met Ala Leu Ser Ala Gly Ala Asp Lys
85 90 95
Val Ala Val Asn Thr Ala Ala Ile Leu Asn Pro Lys Phe Ile Thr Glu
100 105 110
Ile Ala Lys Arg Tyr Gly Ser Gln Cys Val Val Ala Ser Ile Gln Ala
115 120 125
Lys Arg Ile Gly Asn Asp Trp Glu Ala Tyr Met Glu Ala Gly Arg Glu
130 135 140
Pro Thr Gly Lys Asn Val Val Ala Trp Ser Lys Glu Leu Glu Asp Leu
145 150 155 160
Gly Ala Gly Glu Ile Leu Leu Thr Ser Ile Asp Gln Asp Gly Thr Lys
165 170 175
Lys Gly Phe Asp Leu Pro Leu Leu Gly Ala Val Asn Thr Ile Val Asn
180 185 190
Ile Pro Val Met Val Ser Gly Gly Cys Gly Asn Pro Asp His Val Gln
195 200 205
Glu Leu Lys Glu Ile Gln Pro Ser Gly Val Cys Leu Ala Ser Val Leu
210 215 220
His Tyr Lys Ile Asn Thr Ile Asp Glu Phe Lys Gln Arg Leu Thr Phe
225 230 235 240
Ile Asn Gly Thr Lys
245
<210> 68
<211> 212
<212> PRT
<213> 糖原甲基菌
<400> 68
Met Lys Lys Ile Cys Ile Leu Asp Tyr Gly Leu Gly Asn Val Arg Ser
1 5 10 15
Val Ser Asn Ala Ile Lys Tyr Val Gly Ala His Pro Val Ile Ser Asn
20 25 30
Thr Pro Glu Ala Leu Lys Asp Ser His Ala Leu Ile Val Pro Gly Val
35 40 45
Gly Ala Phe Ala Gln Gly Met Ser Ala Leu Gly Lys Asp Gly Leu Gln
50 55 60
Ala Ser Leu Leu Glu Tyr Ile Lys Ser Gly Lys His Val Leu Gly Ile
65 70 75 80
Cys Leu Gly Met Gln Leu Leu Phe Asp Arg Gly Glu Glu Phe Gly Val
85 90 95
Thr Thr Gly Leu Gly Leu Val Pro Gly Val Val Ser Arg Ile Val Pro
100 105 110
Val Glu Gln Ser Arg Val Arg Leu Pro His Ile Ser Trp Ala Lys Val
115 120 125
Asp Leu Asn Ser Val His Glu Asn Asn Gly Gly Met Phe Asp Gly Leu
130 135 140
Pro Asp Glu Gln Arg Lys Phe Tyr Phe Leu His Ser Tyr Ala Ala Gln
145 150 155 160
Asn Val Pro Asp Arg Tyr Ile Thr Gly Ser Ala Thr Tyr Ser Gly Cys
165 170 175
Thr Phe Val Ala Ser Val Gln Lys Asp Asn Ile Trp Gly Met Gln Phe
180 185 190
His Pro Glu Lys Ser Gly Pro Ser Gly Leu Gln Val Leu Asn Asn Phe
195 200 205
Val Gln Asn Ser
210
<210> 69
<211> 408
<212> PRT
<213> 糖原甲基菌
<400> 69
Met Lys Arg Ser Val Glu Glu Val Val Val Asn Ala Tyr Phe Gly Leu
1 5 10 15
Pro Glu Asp Val Val Phe Cys Lys Lys Cys Val Ile Ser Asn Gln Arg
20 25 30
Pro Ser Ser Thr Val Glu Phe Lys His Thr Asn Lys Asp Lys Lys Ala
35 40 45
Thr Ile Gly Phe Gly Ala Asp Gly Ile Cys Asp Ala Cys Arg Tyr Ala
50 55 60
Glu Thr Lys Asp Ala Gln Ile Asp Trp Gln Ala Arg Glu Asp Ala Leu
65 70 75 80
Val Arg Leu Leu Asp Gln His Arg Arg Ser Asp Gly Gly Tyr Asp Ile
85 90 95
Val Val Pro Gly Ser Gly Gly Lys Asp Ser Ala Tyr Thr Ser His Ile
100 105 110
Leu Lys Tyr Lys Tyr Gly Met Asn Pro Leu Thr Val Thr Trp Ala Pro
115 120 125
His Lys Tyr Thr Glu Ile Gly Trp Lys Asn Phe Glu Asn Trp Ile His
130 135 140
Lys Gly Gly Leu Asp Asn Ile Leu Phe Thr Pro Asn Gly Lys Leu His
145 150 155 160
Arg Tyr Leu Thr Lys Met Ala Phe Leu Asn Leu Leu His Pro Phe Gln
165 170 175
Pro Phe Ile Val Gly Gln Arg Ile Ile Gly Pro Leu Met Ala Lys Lys
180 185 190
Phe Gly Ile Lys Leu Val Met Tyr Gly Glu Asn Gln Ala Glu Tyr Gly
195 200 205
Asn Lys Thr Glu Glu Asn Tyr Lys Pro Thr Met Asp Lys Asn Phe Phe
210 215 220
Ser Ile Ser Asp Pro Ala Asp Met Val Leu Gly Gly Val Lys Val Gly
225 230 235 240
Asp Ile Ile Lys Asp Gly Glu Tyr Ser Leu Asn Asp Phe Ala Pro Tyr
245 250 255
Ile Pro Pro Ala Ala Glu Asp Leu Glu Arg Asp Gly Ile Glu Val His
260 265 270
Tyr Leu Gly Tyr Tyr Leu Lys Trp Asp Pro Gln Glu Cys Tyr Tyr Tyr
275 280 285
Ala Val Glu His Thr Gly Phe Gln Ala Asn Thr Glu Arg Thr Glu Gly
290 295 300
Thr Tyr Ser Lys Tyr Ser Ser Ile Asp Asp Arg Ile Asp Met Phe His
305 310 315 320
Tyr Phe Thr Thr Leu Ile Lys Phe Gly Ile Gly Arg Ala Thr Tyr Asp
325 330 335
Ala Ala Gln Glu Ile Arg Asn Asp Lys Ile Thr Arg Glu Glu Gly Val
340 345 350
Ala Leu Val His Lys Tyr Asp Gln Glu Phe Pro Lys Lys Tyr Phe Ala
355 360 365
Glu Phe Leu Glu Tyr Ile Glu Ile Thr Glu Ala Gln Phe Trp Glu Thr
370 375 380
Val Asp Arg Phe Arg Ser Pro His Leu Trp Glu Lys Gln Asp Ser Asn
385 390 395 400
Trp Ile Leu Lys His Gln Val Thr
405
<210> 70
<211> 397
<212> PRT
<213> 糖原甲基菌
<400> 70
Met Asp Thr Glu Ala Ser Gly Asp Leu Arg Met Lys Val Leu Gln Ile
1 5 10 15
Gly Ser Phe Ser Gly Asn Val Gly Asp Ile Ala Asn His Tyr Gly Phe
20 25 30
Arg Asn Trp Phe Gln Gly Leu Leu Gly Glu Ile Gln Trp Asp Glu Phe
35 40 45
Glu Ile Arg Asn Val Tyr Arg Lys Asn Val Ala Phe Asp Asp Asn Phe
50 55 60
Val Ala Ile Ala Asn Gln Tyr Asp Leu Ile Val Val Gly Gly Gly Asn
65 70 75 80
Phe Phe Glu Leu Trp Val Asp Ser Ser Pro Thr Gly Thr Ser Ile Ser
85 90 95
Ile Glu Ile Glu Val Phe Lys Lys Ile Lys Val Pro Ile Phe Phe Asn
100 105 110
Ala Leu Gly Val Asp Asp Gly Met Gly Cys Ser Asp Glu Ser Leu Ala
115 120 125
Lys Phe Thr Asn Phe Leu Glu Ile Leu Thr Ser Ser Lys Gln Tyr Leu
130 135 140
Val Ser Val Arg Asn Asp Gly Ala Met Gly Thr Leu Arg Asn Arg Ile
145 150 155 160
Ser Asn Asn Pro Met Leu Asp Lys Val Leu Pro Leu Pro Asp Gly Gly
165 170 175
Phe Phe Val Asn Leu Asp Lys Leu Glu Lys Asp Ile Ala Glu Asn Asp
180 185 190
His Glu Asn Thr Gln Ile Thr Ile Gly Ile Asn Leu Ala Gly Asp Met
195 200 205
Leu Glu Thr Arg Phe Pro Gly Gly Ile Asn Gly Tyr Asp Tyr Ser Gly
210 215 220
Phe Ile Ser Glu Phe Thr Glu Thr Leu Ala Glu Met Trp Asn Lys Asn
225 230 235 240
Lys Leu Ile Lys Phe Ile Phe Phe Pro His Ile Tyr Ser Asp Leu Lys
245 250 255
Val Tyr Ala Asp Ile Leu Ser Arg Leu Pro Asp Ala Cys Arg Arg Glu
260 265 270
Asn Val Lys Val Ala Ser Tyr Asp Thr Asn Val Asn Phe Gln Gly Thr
275 280 285
Leu Phe Ser Glu Tyr Ser Lys Cys Thr Leu Ile Leu Gly Met Arg Phe
290 295 300
His Ala Asn Val Val Ala Ile Ala Asn Lys Ile Pro Val Ile Gly Leu
305 310 315 320
Tyr Ser Tyr Lys Gln Ile Lys Glu Leu Phe Tyr Glu Leu Gly Ile Lys
325 330 335
Glu Lys Ile Val Asp Val Arg Gln Ile Gly Phe Lys Asn Glu Leu Leu
340 345 350
Arg Lys Cys Asn Ile Val Ile Glu Asn Ser Ser Ile Ser Arg Asp Glu
355 360 365
Ser Cys Asn Ile Leu Asp Val Val Thr Lys Lys Arg Asp Leu Ile Ala
370 375 380
Pro Arg Val Val Glu Trp Leu Arg Glu His Lys Leu Lys
385 390 395
<210> 71
<211> 355
<212> PRT
<213> 糖原甲基菌
<400> 71
Met Ile Lys Ser Leu Asp Tyr Leu Arg Ala Ile Ala Ala Leu Thr Val
1 5 10 15
Phe Leu Ser His Thr Phe Gln Ile Tyr Trp Leu Pro Thr Ile Gly Leu
20 25 30
Val Ser Trp Lys Tyr Glu Leu Asn His Phe Leu Ser Glu Thr Ala Val
35 40 45
Leu Leu Phe Phe Val Leu Ser Gly Tyr Val Ile Ser Asn Ser Leu His
50 55 60
Ser Asn Thr Gln Arg Asn Gly Gly Arg Leu Ser Val Leu Asp Tyr Ala
65 70 75 80
Ser Ser Arg Leu Leu Arg Ile Tyr Pro Pro Leu Ile Val Ser Ile Ile
85 90 95
Ile Ser Leu Val Ala Tyr Ser Val Ile Val Ile Phe Glu Leu Pro Gly
100 105 110
Ser Val Gly Thr Leu Lys Ala Pro Gly Asp Ile Tyr Gln Ala Arg Asp
115 120 125
Tyr Leu Ser Ile Gly Thr Arg Asp Ile Val Asn Ser Leu Leu Met Asn
130 135 140
Asn Gly Leu Leu Gln Met Asn Gly Pro Leu Trp Ser Leu Cys Ile Glu
145 150 155 160
Ala Lys Leu Tyr Phe Tyr Ala Cys Leu Val Val Ile Ile Phe Ile His
165 170 175
Tyr Lys Gln Lys Asn Leu Leu Asn Phe Ile Ala Asn Thr Gly Phe Leu
180 185 190
Val Leu Ser Val Phe Leu Phe Phe Asn Thr Lys Thr Asp Ile Tyr Tyr
195 200 205
Gly Leu Trp Trp Leu Ser Gly Gly Val Ile Phe Leu Tyr Arg Arg Asn
210 215 220
Phe Ile Lys Phe Met Thr Leu Val Val Val Met Ala Ile Val Val Phe
225 230 235 240
Ala Met Ala Val Ile Gly Gln Lys Phe Val Ser Leu Pro Val Gln Val
245 250 255
Ile Phe Val Tyr Ser Leu Phe Leu Ala Ala Ile Lys Cys Lys Val Pro
260 265 270
Glu Ile Lys Ala Met Asn Ile Leu Ala Asn Thr Ser Tyr Thr Leu Tyr
275 280 285
Ile Val His Phe Pro Met Leu Leu Leu Ser Tyr Ala Ile Phe Ser Tyr
290 295 300
Asn Phe Asp Val Tyr Gly Ser Leu Thr Arg Glu Leu Met Ser Ser Leu
305 310 315 320
Ser Leu Ile Ile Ile Leu Thr Met Ser Ile Tyr Ile Gly Lys Trp Val
325 330 335
Glu Arg Pro Ala Asn Leu Arg Leu Thr Tyr His Arg Leu Leu Arg Lys
340 345 350
Val Lys Val
355
<210> 72
<211> 559
<212> PRT
<213> 糖原甲基菌
<400> 72
Met Lys Ala Met Phe Tyr Ser Leu His Ala Ala Ile Trp Leu His Ala
1 5 10 15
Leu Pro Glu Ser Arg Leu Ala Ser Gln Leu Ser Asn Ala Gly His Glu
20 25 30
Leu Val Tyr Val Thr Cys Asp Lys Ser Phe Thr His Tyr Cys Thr Gly
35 40 45
Met Ser Ala Phe Asn Leu Ala Leu Asn Glu Asp Phe Lys Lys Lys Ser
50 55 60
Ala Ile Cys Glu Leu Cys Ile Asn Asn Ala Asn Lys Ile Thr Lys Ser
65 70 75 80
Phe Asp Cys Lys His Leu Lys Leu His Asp Tyr Ile Asp Gln Lys Thr
85 90 95
Asn Ala Leu Ile Asp Asn Leu Leu Lys Ser Val Thr Glu Asp Asn Phe
100 105 110
Leu Glu Phe His Tyr Glu Asp Ile Pro Val Gly Arg Leu Ala Thr Tyr
115 120 125
Glu Pro Leu Leu Lys Tyr Lys Lys Met Ser Leu Glu Phe Arg Asp Glu
130 135 140
Gln Trp Gln Asp Leu Gln Ile His Leu Arg Asn Ala Leu Val Ser Leu
145 150 155 160
Ile Gly Phe Ile Gln Ile Phe Lys Gln Glu Cys Pro Glu Lys Ile Phe
165 170 175
Phe Tyr Ser Pro Gln Tyr Gly Val Asn Gly Val Cys Ala Glu Tyr Ala
180 185 190
Val Lys Gln Gly Arg Gln Ala Tyr Phe Ile Glu Gly Ser Ser Ser Asn
195 200 205
Ala Glu Arg Tyr Ser Ala Leu Arg Val Trp Glu Trp Ser Lys Phe Lys
210 215 220
Leu Val Asn Pro Ala Leu Gln His Trp Gln Ala Val Lys Asn Leu Val
225 230 235 240
Thr Leu Glu Asp Ile Asp Arg Val Ser Ala His Ile His Glu Leu Phe
245 250 255
Lys Gly Lys Ser Phe Ala Val Phe Ser Ala Pro Lys Thr Gly Asn Phe
260 265 270
Ser Ile Arg Glu Lys Phe Asn Ile Pro Gln Asn Ala Lys Ile Leu Leu
275 280 285
Ala Ser Leu Ser Ser Phe Asp Glu Ala Tyr Ala Ala Phe Val Ile Lys
290 295 300
Gly Phe Pro Glu Arg Lys Val Lys Ser Pro Val Phe Ser Asp Gln Phe
305 310 315 320
Glu Trp Ile Lys Cys Thr Ile Asn Phe Met Lys Ser Arg Pro Asp Asp
325 330 335
Tyr Leu Val Ile Arg Val His Pro Arg Asp Tyr Pro Asn Lys Arg Asp
340 345 350
Ser Asn Gln Ser Glu Gln Ala Leu Ile Trp Glu Lys Ile Leu Gln Asp
355 360 365
Leu Pro Glu Asn Val Lys Leu Asn Ser Pro Asp Gln Asn Ile Ser Leu
370 375 380
Tyr Asp Phe Leu Asp Asp Val His Ala Leu Val Thr Gly Trp Ser Ala
385 390 395 400
Thr Gly Val Glu Ala Leu Leu His Gly Ile Pro Val Ile Thr Tyr Asp
405 410 415
Lys Tyr Leu Pro Ser Tyr Pro Ala Asp Ile His Leu Thr Gly Glu Ser
420 425 430
Glu His Glu Tyr Tyr Asp Asn Leu Ile Lys Val Leu Ser Leu Ala Thr
435 440 445
Ser Thr Asp Asn Thr His Val Val Asn Ala Tyr Arg Trp Leu Ala Val
450 455 460
Ser Phe Ser Leu Gly Thr Val Arg Val Asn Gln Pro Leu Glu Ile Gly
465 470 475 480
Leu Ser Trp Pro Asp Lys Pro Ala Tyr Arg Ile Leu Lys Arg Val Ala
485 490 495
Asn Lys Phe Ser Val Asn Leu Arg Lys Ser Tyr Asp Val Trp Asn Val
500 505 510
Gln Ser Asn Asp Thr Asp Arg Leu Arg Phe Leu Ser Leu Val Leu Asn
515 520 525
Asn Gln Ser Ser Leu Phe Glu Gly Val Ile Ser Asp Val Val Asp Ala
530 535 540
Val Ser Asp Tyr Glu Ile Glu Ala Thr Val Lys Gln His Ser Ile
545 550 555
<210> 73
<211> 568
<212> PRT
<213> 糖原甲基菌
<400> 73
Met Asn Lys Leu Pro Gln Ala Lys Tyr Ile Phe Lys Leu Leu Lys Phe
1 5 10 15
Ala Phe Asn Asn Asn Pro Leu Leu Tyr Leu Ser Val Leu Ile Ser Ile
20 25 30
Leu Ser Ile Gly Ile Glu Leu Leu Ala Met Ala Ser Leu Leu Pro Leu
35 40 45
Phe Glu Leu Val Ser Gly Glu Thr Val Asp Lys His Gly Leu Ile Ser
50 55 60
Lys Ala Leu Ile Ile Leu Gly Phe Thr Val Asp Ala Ala Ser Leu Leu
65 70 75 80
Gln Val Phe Phe Leu Leu Phe Thr Leu Arg Val Val Thr Gln Leu Phe
85 90 95
Ser Gln Ser Leu Thr His Tyr Leu Gly Arg Arg Val Met Ala Gln Leu
100 105 110
Gly Ser Arg Ala Phe Glu Lys Ile Ile Thr Ser Met Ser Ile Asp Lys
115 120 125
Ile Ser Glu Lys Ser Ile Gly Phe Phe Met Gly Leu Ala Gly Asp Glu
130 135 140
Ser Phe Arg Ala Ser Thr Leu Val Val Ala Leu Thr Gln Phe Val Ala
145 150 155 160
Thr Phe Leu Leu Gly Val Met Tyr Phe Ile Ser Ile Ala Ile Tyr Ser
165 170 175
Leu Tyr Ala Ala Glu Met Ile Phe Ile Leu Met Leu Val Ser Ala Val
180 185 190
Phe Phe Ile Trp Ile Leu Lys Ile Ser His Lys Met Gly Val Arg Gln
195 200 205
Ile Glu Gly Ser Arg Lys Ala Asn Ser Ile Phe Met Asp Ala Met Asn
210 215 220
Asn Ile Lys Ala Val Arg Ser Leu Ser Ser Glu Lys Tyr Val Ala Gly
225 230 235 240
Leu Tyr Arg Arg Lys Ile Phe Thr Tyr Ala Asn Ile Leu Phe Tyr Leu
245 250 255
Asp Ala Ile Asn Leu Ala Thr Lys Leu Val Pro Ile Ile Phe Leu Leu
260 265 270
Leu Gly Ser Leu Ala Leu Ile Leu Ser Gly Trp Val Ser Val Glu Asn
275 280 285
Leu Gly Met Ala Tyr Ile Val Ser Leu Ile Ala Tyr Leu Met Arg Phe
290 295 300
Phe Pro Val Val Gly Gln Ser Ile Thr Leu Ala Val Arg Ile Val Ala
305 310 315 320
Asp Ala Lys Ser Gly Lys Asp Val Thr Glu Leu Val Ser Asp Glu Ser
325 330 335
Ala Glu Ser Ala Asn Ser Asp Asn Tyr Leu His Lys Ile Asp Thr Ile
340 345 350
Lys Ile Asp Asn Leu Ser Phe Ser Tyr Arg Asp Val Gln Gly Val Arg
355 360 365
Pro Ala Val Leu Asn Ser Val Tyr Tyr Glu Phe Glu Lys Asn Asn Ser
370 375 380
Tyr Ala Leu Val Gly Lys Ser Gly Leu Gly Lys Ser Thr Leu Leu Asp
385 390 395 400
Val Leu Leu Lys Phe Tyr Pro Pro Ala Ser Gly Ser Ile Ser Ile Asp
405 410 415
Gly Ile Ser Thr Glu Asn Ile Pro Gly Ala His Ile Arg His Ser Ile
420 425 430
Val Leu Ile Asn Gln Glu Pro Ala Ile Phe Asp Asp Thr Val Tyr Asn
435 440 445
Asn Ile Cys Met Gly Glu Thr Phe Thr Leu Glu Asp Val Lys Trp Ala
450 455 460
Cys Glu Leu Ala Cys Ile Ser Lys Asp Val Glu Ser Leu Ala Gln Gly
465 470 475 480
Tyr Glu Thr Arg Leu Gln Tyr Gln Gly Lys Asn Leu Ser Gly Gly Gln
485 490 495
Arg Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Arg Lys Pro Asn Val
500 505 510
Leu Ile Leu Asp Glu Ser Thr Thr Ala Leu Asp Lys Ala Thr Gln Glu
515 520 525
Ile Val Ile Arg Asn Leu Met Asn Glu Tyr Glu Asn Lys Ile Ile Ile
530 535 540
Phe Val Ser His Asp Pro Tyr Ile Met Ser Gln Val Asp His Thr Val
545 550 555 560
Asp Leu Ala Leu Ile Asn Lys Val
565
<210> 74
<211> 232
<212> PRT
<213> 糖原甲基菌
<400> 74
Met Ser Ile Ser Ser Ile Ala Leu Lys Ile Phe Asn Tyr Ser Gln Glu
1 5 10 15
Ile Phe Ser Phe Tyr Arg Asp Arg Gly Leu Tyr Lys Phe Ser Tyr Ala
20 25 30
Gln Glu Gly Glu Asp Leu Ile Leu Ser Arg Ile Phe Asp Arg Thr Ser
35 40 45
Thr Gly Tyr Tyr Ile Asp Ile Gly Ala His His Pro Val Arg Phe Ser
50 55 60
Asn Thr Tyr Leu Phe Tyr Lys Arg Gly Trp Arg Gly Val Cys Ile Asp
65 70 75 80
Pro Ser His Glu Ala Ile Ala Leu Phe Lys Thr Arg Arg Pro Ala Asp
85 90 95
Ile Ala Leu Glu Met Gly Val Ser Asp His Glu Ser Glu Leu Thr Tyr
100 105 110
His Met Phe Asp Glu Pro Ala Leu Asn Thr Phe Ser Glu Glu Leu Ala
115 120 125
Asn Gln Arg Ile Gln Asn Thr Ala Tyr Lys Arg Val Gly Thr Arg Lys
130 135 140
Val Pro Val Arg Pro Leu Thr Lys Ile Leu Asp Glu Val Leu Leu Pro
145 150 155 160
Asp Thr Glu Ile Asp Phe Met Ser Ile Asp Val Glu Gly Phe Asp Tyr
165 170 175
Gln Val Leu Ala Ser Asn Asp Trp Ser Lys Tyr Arg Pro Arg Ile Val
180 185 190
Leu Ala Glu Ala Leu Asp Asp Val Ala Gly Glu Arg Ile Arg Ser Phe
195 200 205
Met Ile Gln Asn His Tyr Lys Val Ile Ala Arg Thr Phe Asn Thr Glu
210 215 220
Phe Tyr Gln Asp Leu Leu Lys Leu
225 230
<210> 75
<211> 301
<212> PRT
<213> 糖原甲基菌
<400> 75
Met Ser Asn Leu Ala Pro Val Ala Leu Phe Thr Tyr Asn Arg Pro Asp
1 5 10 15
His Thr Lys Arg Thr Ile Glu Ala Leu Lys Asn Asn Thr Leu Ser Ala
20 25 30
Glu Thr Asp Leu Leu Ile Phe Ser Asp Ala Ala Lys Asn Ile Thr Gln
35 40 45
Gln Ser Met Val Asp Ala Val Arg Ala Phe Thr His Thr Val Glu Gly
50 55 60
Phe Lys Ser Val Arg Ile Ile Glu Arg Gln Thr Asn Phe Gly Leu Ala
65 70 75 80
Ala Ser Ile Ile Asp Gly Val Thr Asn Val Leu Ala Glu Tyr Gly Arg
85 90 95
Ile Ile Val Leu Glu Asp Asp Met Val Thr Ser Pro Tyr Phe Leu Gln
100 105 110
Tyr Met Asn Asp Ser Leu Ser Gln Tyr Ala Asp Phe His Glu Val Ala
115 120 125
Ser Ile His Ala Tyr Val Tyr Pro Ile Ala Gly Leu Pro Asp Thr Phe
130 135 140
Phe Leu Arg Gly Ala Asp Cys Trp Gly Trp Ala Thr Trp Arg Asp Arg
145 150 155 160
Trp Asp Trp Phe Glu Pro Asp Gly Ser Lys Leu Phe Ala Gln Leu Lys
165 170 175
Gln Leu Asn Leu Leu Asn Lys Phe Asp Tyr Asn Gly Ser Tyr Pro Phe
180 185 190
Ser Asn Met Leu Arg Asp Gln Ile Ala Gly Thr Asn Asn Ser Trp Ala
195 200 205
Ile Arg Trp His Ala Ser Ala Phe Leu Leu Asn Lys Leu Thr Leu Tyr
210 215 220
Pro Gly Lys Ala Leu Leu Ser Asn Ile Gly His Asp Gly Ser Gly Val
225 230 235 240
His Cys Gly Glu Ser Glu Thr Tyr Ser Ala Glu Leu Arg Ala Asp Arg
245 250 255
Leu Leu Leu Thr Asp Ile Pro Leu Arg Glu Ser Glu Pro Ala Phe Lys
260 265 270
Lys Phe Glu Gln Phe Phe Leu Glu Ser Lys Pro Ser Val Val Arg Lys
275 280 285
Met Met Leu Lys Ala Lys Ser Val Phe Lys Lys Phe Leu
290 295 300
<210> 76
<211> 271
<212> PRT
<213> 糖原甲基菌
<400> 76
Met Ser Phe Ile Lys Ile Leu Lys Leu Leu Cys Pro Pro Leu Phe Leu
1 5 10 15
His Ile Leu Gln Lys Tyr Arg Arg Arg Asn Phe Ala Ser Ser Phe Ala
20 25 30
Gly Asn Tyr Ser Ser Trp Ala His Ala Lys Gln Asn Ser Gly Gly Tyr
35 40 45
Asp Ala Glu Asn Ile Leu Thr Ile Ile Gln Glu Ser Ala Leu Lys Val
50 55 60
Lys Arg Gly Glu Ala Val Phe Glu Arg Asp Ser Val Cys Phe His His
65 70 75 80
Val Glu Tyr Arg Tyr Ser Ala Leu Ser Gly Leu Leu Tyr Ala Ala Val
85 90 95
Ser Ser Gly Gly Lys Leu Ser Val Leu Asp Phe Gly Gly Ser Leu Ala
100 105 110
Ser Phe Tyr Ser Gln His Ala Ala Ile Leu Ser Ile Val Lys Asp Leu
115 120 125
Arg Trp Gly Val Val Glu Gln Pro His Phe Val Ala Trp Gly Arg Glu
130 135 140
His Leu Thr Thr Thr Asp Leu Lys Phe Tyr Asn Ser Leu Thr Glu Phe
145 150 155 160
Ile Leu Asp Gly Lys Pro Asn Val Ile Phe Leu Ser Ser Val Leu Gln
165 170 175
Tyr Leu Glu His Pro Tyr Gln Leu Leu Glu Glu Leu Leu Arg Leu Asp
180 185 190
Ser Glu Phe Ile Leu Phe Asp Arg Thr Ala Phe Tyr Asp Val Val Asp
195 200 205
Arg Leu Thr Val Gln Thr Val Pro Ala Ser Ile Tyr Pro Ala Ser Tyr
210 215 220
Pro Ala Trp Phe Ile Ser Trp Asp Lys Phe Ile Asn Thr Met Ser Ala
225 230 235 240
Gly Gly Tyr Glu Val Ile Met Glu Phe Pro Cys Ala Asp Leu Thr Asp
245 250 255
Ile Gly Tyr Tyr Lys Gly Leu Phe Phe Lys Arg Lys Ser Val Ser
260 265 270
<210> 77
<211> 332
<212> PRT
<213> 糖原甲基菌
<400> 77
Met Asn Asp Glu Leu Tyr Ser Gly Lys Asn Ile Leu Val Thr Gly Gly
1 5 10 15
Leu Gly Phe Ile Gly Ser Asn Leu Val Lys Arg Leu Ile Ala His Lys
20 25 30
Ala Lys Val Thr Val Val Asp Ser Leu Leu Pro Leu Tyr Gly Gly Asn
35 40 45
Ala Phe Asn Leu Ser Gly Tyr Glu Ser Leu Val Asn Ile Asn Ile Ser
50 55 60
Asp Val Arg Asp Ser His Ala Met Ala Tyr Leu Ile Lys Gly Lys Asp
65 70 75 80
Tyr Leu Phe Asn Leu Ala Gly Gln Thr Ser His Leu Asp Ser Met Thr
85 90 95
Asp Pro Arg Thr Asp Leu Asp Ile Asn Ala Ala Ala Gln Leu Ser Ile
100 105 110
Leu Glu Ala Cys Arg Gln His Asn Pro Asp Val Arg Ile Val Phe Ala
115 120 125
Ser Thr Arg Gln Leu Tyr Gly Lys Pro Glu Tyr Leu Pro Val Asp Glu
130 135 140
Ser His Pro Ile Gln Pro Val Asp Val Asn Gly Ile Asn Lys Leu Ala
145 150 155 160
Gly Glu Trp Tyr His Ile Leu Tyr Asn Asn Val Tyr Gly Ile Lys Ala
165 170 175
Cys Ala Leu Arg Leu Thr Asn Thr Tyr Gly Pro Gly Met Arg Val Lys
180 185 190
Asp Ala Arg Gln Thr Phe Leu Gly Ile Trp Leu Arg Arg Val Ile Glu
195 200 205
Gly Lys Pro Ile Ala Val Phe Gly Asp Gly Leu Gln Leu Arg Asp Phe
210 215 220
Asn Tyr Val Asp Asp Val Val Asp Ala Leu Leu Leu Ala Ala Ala Asn
225 230 235 240
Thr Glu Ala Asp Gly Gln Ile Phe Asn Leu Gly Ser Asp Glu Val Val
245 250 255
Asn Leu Gln Gln Val Ala Glu Leu Met Thr Gln Phe Gln Pro Gly Ser
260 265 270
Ser Tyr Glu Ile Val Pro Phe Pro Pro Glu Arg Lys Ala Ile Asp Ile
275 280 285
Gly Asp Tyr Tyr Ser Asp Phe Asn Lys Ile Lys Gln Val Leu Gly Trp
290 295 300
Ser Pro Arg Val Gly Leu Gln Gln Gly Leu Ala Ala Ser Leu Ala Tyr
305 310 315 320
Tyr Arg Gln His His Asp Lys Tyr Trp Asp Asn Val
325 330
<210> 78
<211> 366
<212> PRT
<213> 糖原甲基菌
<400> 78
Met Ile Leu Met Asn Asp Phe Lys Ala Glu Pro Glu Ala Leu Ile Ala
1 5 10 15
Ala Gln Leu Gln Ala Val Glu Arg Val Leu Arg Ser Gly Trp Tyr Val
20 25 30
Leu Gly Glu Glu Gly Arg Lys Phe Glu Ser Leu Trp Ser Gln Arg Cys
35 40 45
Gly Thr Ser His Thr Val Gly Val Gly Asn Gly Met Asp Ala Ile Glu
50 55 60
Ile Gly Leu Arg Ala Leu Asp Ile Gly Pro Gly Asp Glu Val Ile Thr
65 70 75 80
Thr Ala Met Thr Ala Phe Ala Ser Val Leu Ala Ile Ile Arg Ala Gly
85 90 95
Ala Thr Pro Val Leu Ala Asp Ile Asp Pro Asp Thr Gly Leu Leu Ser
100 105 110
His Glu Ser Val Lys Arg Cys Ile Asn Ser Arg Thr Lys Ala Val Leu
115 120 125
Leu Val His Leu Tyr Gly Gln Ile Arg Asp Met Gln Ser Trp Leu Asn
130 135 140
Leu Cys Asp Gln His Gln Val Ala Leu Leu Glu Asp Cys Ala Gln Ala
145 150 155 160
His Leu Ala Gln Ala Glu Gly Lys Val Ala Gly Ser Phe Gly Arg Phe
165 170 175
Gly Ala Tyr Ser Phe Tyr Pro Thr Lys Asn Leu Gly Ala Ile Gly Asp
180 185 190
Gly Gly Ala Leu Val Thr Ser Gln Ser Ala Leu Ala Asp Lys Ala Ala
195 200 205
Val Leu Arg Asn Tyr Gly Gln Ser Val Arg Tyr His His Pro Glu Phe
210 215 220
Gly Leu Asn Ser Arg Leu Asp Glu Ile Gln Ala Ala Leu Leu Thr Val
225 230 235 240
Arg Leu Glu Trp Leu Glu Gln Tyr Thr Ser His Arg Gln Ser Ile Ala
245 250 255
Ala Gln Tyr Arg Gln Gln Leu Asn Asn Pro Tyr Val Arg Leu Met Gln
260 265 270
Thr Pro Thr Glu Pro Leu Ala His Val Tyr His Leu Phe Val Val Leu
275 280 285
Thr Glu His Arg Glu Ala Leu Gln Ala His Leu Gln Ala Asn Gly Val
290 295 300
Gln Ala Leu Ile His Tyr Pro Val Pro Ile His His Gln Glu Lys Cys
305 310 315 320
Ser Asp Ile Leu Arg Asp Pro Ala Gly Leu Gln Phe Ser Glu Ala His
325 330 335
Ala Gln Gln Cys Leu Ser Leu Pro Cys His Pro Gln Met Ser Glu Gln
340 345 350
Asp Val Gln Thr Val Ile Ala Ala Val Asn Arg Phe Ala Leu
355 360 365
<210> 79
<211> 313
<212> PRT
<213> 糖原甲基菌
<400> 79
Met Glu His Phe Val Thr Leu Phe Asp Ser Lys Phe Leu Pro Gln Gly
1 5 10 15
Leu Cys Leu His Glu Ser Leu Ala Arg His Ala Arg Asp Phe His Leu
20 25 30
Trp Ile Val Cys Met Asp Lys Val Val His Glu Gln Leu Glu Lys Leu
35 40 45
Gln Leu Pro His Val Ser Leu Met Arg Leu Ala Asp Phe Glu Ser Glu
50 55 60
Ala Leu Leu Ala Val Lys Pro Gly Arg Thr Lys Gly Glu Tyr Cys Trp
65 70 75 80
Thr Ile Thr Pro Phe Thr Ala Glu Trp Val Phe Ala Gln His Pro Glu
85 90 95
Val Ala Arg Val Thr Tyr Leu Asp Ala Asp Leu Phe Phe Phe Asn Asp
100 105 110
Pro Ala Ile Leu Phe His Glu Phe Glu Gln Ser Gly Lys His Val Met
115 120 125
Ile Thr Glu His Ala Tyr Ala Pro Asp Tyr Ile Gln His Leu Glu Thr
130 135 140
Ser Gly Arg Phe Cys Val Gln Phe Met Val Phe Asp Arg Ser Glu Ala
145 150 155 160
Ser Arg Lys Val Met His Trp Trp Gln Asp Arg Cys Val Glu Trp Cys
165 170 175
Phe Ala Arg Met Glu Asp Gly Lys Phe Gly Asp Gln Lys Tyr Leu Asp
180 185 190
Leu Trp Pro Thr Ile Phe Ala Asp Asp Val His Ile Leu Lys Cys Val
195 200 205
Glu Gln Thr Leu Ala Pro Trp Asn Val Asp Tyr Gln Leu Gln His Gln
210 215 220
Ser Gly Lys Phe Lys Pro Val Phe Tyr His Phe His Ala Phe Arg Ile
225 230 235 240
Ile Lys Phe Asn Leu Val Arg Leu Tyr Glu Gly Tyr Gln Ile Ala Lys
245 250 255
Ser Ser Arg Tyr Leu Tyr Asp Glu Tyr Leu Ala Thr Leu Gln Lys Lys
260 265 270
Ile Gly Met Leu His Arg Phe Ala Ile Pro Leu Pro Leu Leu Pro Glu
275 280 285
Lys Cys Gly Ile Arg Pro Lys Leu Ala Ser Tyr Tyr Thr Trp Ile Arg
290 295 300
Gly Phe Thr Ala Thr Ala Lys Ile Lys
305 310
<210> 80
<211> 255
<212> PRT
<213> 糖原甲基菌
<400> 80
Met Gln Lys Leu Ser Val Ile Thr Ala Thr Tyr Asn Ala Ala Lys Asn
1 5 10 15
Leu Pro Asp Leu Val Gln Ser Leu Leu Ser Gln Thr Asp Met Asp Phe
20 25 30
Glu Trp Val Val Ala Asp Gly Gly Ser Ser Asp Glu Thr Ile Ser Tyr
35 40 45
Leu Lys Ser Val Val Gly Ile Asn Leu Leu Leu Ser Ala Gln Gln Asp
50 55 60
Phe Gly Ile Tyr Asp Ala Leu Asn Arg Ala Ile Ser Leu Ser Ser Gly
65 70 75 80
Asp Tyr Tyr Leu Val Leu Gly Ala Asp Asp Ile Leu Tyr Pro His Ala
85 90 95
Val Glu Ala Phe Lys Arg Ala Ala Gly Ile Gly Leu Pro Asp Leu Val
100 105 110
Thr Ala Ser Val Glu Ser Asp His Gly Val Met Ile Ala Gly Ser Gly
115 120 125
Arg Pro Phe Leu Arg Gly Gln Leu Ala Tyr Ile Ser Asn His Ser Val
130 135 140
Gly Thr Met Ile Lys Lys Ser Leu His Asp Arg Phe Gly Tyr Tyr Ser
145 150 155 160
Arg Arg Phe Pro Ile Thr Ala Asp Gln Tyr Phe Ile Lys Arg Val Cys
165 170 175
Gly Ala Ser Glu Thr Val Ile Tyr Lys Ala Asp Phe Val Ala Gly Tyr
180 185 190
Tyr Pro Ala Thr Gly Val Ser Gly Ala Asp Val Pro Gly Thr Met Val
195 200 205
Glu Phe Phe Arg Val Gln Leu Glu Thr Glu Pro Asn Ser Val Leu Gln
210 215 220
Leu Val Leu Phe Ile Leu Arg Leu Ile Arg His Thr Pro Lys Leu Ile
225 230 235 240
Arg Tyr Ala His Tyr Lys Lys Leu Arg Asp Leu Pro Gln His Glu
245 250 255
<210> 81
<211> 360
<212> PRT
<213> 糖原甲基菌
<400> 81
Met Asn Ser Asn Val Leu Phe Ile Thr Gly Phe His Pro Gly Gly Met
1 5 10 15
Gly Phe Ile Gly Ala Gly Glu Ala Ile Ser Gln Gln His Ile Glu Arg
20 25 30
Leu Ile Lys Gln Gly Arg Lys Val His Val Leu Ala Leu Ala Pro Asn
35 40 45
Tyr Gln Val Ala Ser Pro Glu Val Val Ala Ser Cys Ala Ser Tyr Thr
50 55 60
Thr Leu Thr His Thr Arg Trp Met Thr Phe Ala Ala Leu Trp Arg Ser
65 70 75 80
Arg Gln Gln Gly Ser Leu Leu Cys Pro Trp Leu Phe Thr Arg Val Ser
85 90 95
Pro Gln Ala Glu Arg Phe Ile Arg Gln Leu Leu Asp Gln His Ala Ile
100 105 110
Thr Glu Ile Tyr Leu Asp Phe Pro Ser Cys Leu Gly Phe Ala Pro Thr
115 120 125
Tyr Asn Gln Leu Pro Ile His Tyr Ile Val His Asp Val Leu Ser Gln
130 135 140
Lys Val Glu Arg Arg Pro Leu Leu Lys Trp Leu Lys Asn Gln Val Leu
145 150 155 160
Arg Thr Glu Ser Ser Leu Leu Arg His Val Thr Gln Cys Phe Thr Leu
165 170 175
Ser Leu Lys Asp Lys Leu Arg Cys Glu Glu Ile Gly Tyr Ser Gly Gln
180 185 190
Ile Glu Val Gln Val Pro His Ile Leu Lys Val Gly Val Val Asn Gln
195 200 205
Gly Val Pro Ile Ala Gly Ile Leu Lys Gln Phe Pro Gly Lys Lys Asn
210 215 220
Leu Val Phe Phe Gly Asn Met Gln Arg Ala Glu Asn His Tyr Ser Ile
225 230 235 240
Leu Arg Phe Leu Leu Cys Ser Tyr Pro Gly Ile Trp Leu Glu His Arg
245 250 255
Asp Val Gln Cys Trp Ile Leu Gly Leu Ala Pro Arg Thr Leu Leu Arg
260 265 270
Trp Ile Ser Lys Val Leu Pro Gly Val Arg Val Thr Gly Ala Val Asp
275 280 285
Asp Pro Thr Glu Ala Phe Lys Ala Ala Thr Leu Cys Ile Ala Pro Val
290 295 300
Tyr Tyr Gly Ala Gly Val Lys Ile Lys Val Leu Gln Met Leu Glu Ser
305 310 315 320
Gly Ala Thr Val Ile Ser Thr Pro Val Gly Ala Glu Gly Ile His Gly
325 330 335
Ser Glu Lys Leu Ile Thr Val Glu Ser Ala Arg Leu Ser Ser Thr Ile
340 345 350
Lys Gln Arg Leu Ala Val Glu Ser
355 360
<210> 82
<211> 307
<212> PRT
<213> 糖原甲基菌
<400> 82
Met Asn Gln His Glu Leu Pro Ser Val Ala Val Leu Leu Ala Ser Phe
1 5 10 15
Asn Gly Arg Ala Trp Ile Ala Glu Gln Leu Ala Ser Ile Leu Ala Gln
20 25 30
Gln Gly Val Lys Leu His Val Phe Ile Ala Asp Asp Leu Ser Thr Asp
35 40 45
Gly Thr Trp Glu Trp Leu Asn Val Glu Ala Ala Cys His Gln Asn Val
50 55 60
Thr Leu Leu Pro His Asn Gln Arg Ala Gly Ser Ala Gly Arg Asn Phe
65 70 75 80
Tyr Arg Leu Ile His Glu Val Asp Leu Asp Gly Phe Asp Phe Val Ala
85 90 95
Phe Ala Asp Gln Asp Asp Val Trp Asp Ser Tyr Lys Leu Ser Arg His
100 105 110
Ala Arg Leu Met Lys Leu His Gln Ala Asp Gly Val Ser Ser Asn Val
115 120 125
Glu Ala Phe Trp Pro Asp Gly Arg Val Met Leu Ile Val Lys Ser Gln
130 135 140
Ala Gln Arg Gln Phe Asp Tyr Leu Phe Glu Ser Ala Gly Pro Gly Cys
145 150 155 160
Thr Phe Leu Met Thr Thr Arg Leu Ala His Gln Val Arg Asn Val Leu
165 170 175
Gln Asp Glu Leu Ser Pro Ala Arg Asp Val Thr Leu His Asp Trp Leu
180 185 190
Thr Tyr Ala Ile Ala Arg Ser Leu Gly Tyr Thr Trp Val Ile Asp Ala
195 200 205
Asn Pro Ser Leu Lys Tyr Arg Gln His Gly Asn Asn Val Ile Gly Ala
210 215 220
Asn Val Ser Leu Lys Ala Lys Trp Thr Arg Leu Lys Gln Ile Arg Asp
225 230 235 240
Gly Trp Tyr Arg Gln Gln Val Ile Lys Val Thr Arg Ile Ala Tyr Ala
245 250 255
Phe Ser Gln Arg Glu Asp Leu Gln Arg Leu Leu Val Leu Leu Glu Lys
260 265 270
Pro Ser Leu Gly Asn Arg Leu Gln Leu Leu Pro Tyr Ala Trp His Gly
275 280 285
Arg Arg Ser Val Lys Asp Arg Leu Phe Leu Met Phe Ser Ile Val Phe
290 295 300
Lys Trp Phe
305
<210> 83
<211> 317
<212> PRT
<213> 糖原甲基菌
<400> 83
Met Ser Gln Gln His Ile Leu Val Thr Gly Ala Asn Gly Phe Val Gly
1 5 10 15
Arg Ser Leu Cys Asn Gln Leu Cys Gln Ser Ala Phe Gln Val Thr Gln
20 25 30
Val Gly Arg Ala Leu Asn Ser Ala Asp Gly Gly Ala Tyr Ser Gln Val
35 40 45
Val Ser Ile Asp Gly Thr Thr Asp Trp Ser Thr Ile Leu Asp Glu Val
50 55 60
Glu Val Val Ile His Leu Ala Ala Arg Val His Val Met Gln Glu Asn
65 70 75 80
Leu Val Asp Pro Ile Val Ala Tyr Trp Gln Thr Asn Val Glu Gly Thr
85 90 95
Leu Asn Leu Ala Arg Gln Ala Leu Asn Ala Gly Val Lys Arg Phe Ile
100 105 110
Phe Val Ser Ser Ile Lys Val Asn Gly Glu Gln Ser Phe Pro Gly Lys
115 120 125
Pro Phe Thr Ala Glu Asp Met Pro Met Pro Glu Asp Ala Tyr Gly Lys
130 135 140
Ser Lys Trp Glu Ala Glu Gln Gly Leu Leu Ala Leu Ala Lys Asp Ser
145 150 155 160
Asn Met Val Val Val Ile Ile Arg Pro Pro Leu Val Tyr Gly Pro Gly
165 170 175
Val Lys Gly Asn Phe Ser Thr Met Ile Lys Leu Leu Gln Thr Gly Leu
180 185 190
Pro Leu Pro Phe Gly Ala Ile Ala Asn Gln Arg Ser Leu Val Ala Ile
195 200 205
Asp Asn Leu Ile His Leu Ile Met Val Cys Ile Asn His Pro Ala Ala
210 215 220
Ala Asn Gln Val Phe Leu Val Ser Asp Gly Glu Asp Leu Ser Thr Thr
225 230 235 240
Ala Leu Leu Arg Arg Leu Ala Leu Ala Ala Gly Val Ser Ser Arg Leu
245 250 255
Ile Pro Phe Pro Ala Ala Trp Val Asn Phe Val Phe Thr Val Leu Gly
260 265 270
Lys Lys Met Met Ala Gly Arg Ile Leu Gly Ser Leu Gln Val Asp Ile
275 280 285
Ser Lys Thr Arg Glu Val Leu Gly Trp Gln Pro Pro Val Thr Val Asp
290 295 300
Gln Gly Leu Arg Asn Cys Phe Pro Thr Lys Ala Glu Pro
305 310 315
<210> 84
<211> 183
<212> PRT
<213> 糖原甲基菌
<400> 84
Met Ile Arg Phe Phe Asp Ile Val Phe Ser Leu Leu Gly Leu Val Phe
1 5 10 15
Gly Leu Pro Leu Leu Ile Ile Ile Tyr Leu Val Gly Leu Leu Asp Thr
20 25 30
Gly Ser Pro Leu Phe Arg Gln Val Arg Val Gly Arg His Arg Gln Pro
35 40 45
Phe Thr Leu Val Lys Phe Arg Thr Met Lys Val Asn Thr Ala Ser Val
50 55 60
Ala Ser His Leu Ala Ser Ala Ser Ser Ile Thr Trp Leu Gly Ser Phe
65 70 75 80
Leu Arg Ser Thr Lys Leu Asp Glu Leu Pro Gln Leu Trp Asn Val Leu
85 90 95
Lys Gly Glu Met Ser Leu Val Gly Pro Arg Pro Asn Leu Phe Asn Gln
100 105 110
Asp Glu Leu Ile Ala Ala Arg Asp Ala Arg Gly Val Tyr Ala Val Arg
115 120 125
Pro Gly Ile Thr Gly Leu Ala Gln Val Asn Asp Ile Asp Met Ser Met
130 135 140
Pro Lys Leu Leu Ala Glu Thr Asp Ala Ser Met Leu Gln Gln Leu Asn
145 150 155 160
Leu Lys Leu Tyr Phe Lys Leu Leu Ile Gln Thr Val Leu Gly Lys Gly
165 170 175
Arg Gly Asp Arg Val Val Arg
180
<210> 85
<211> 573
<212> PRT
<213> 糖原甲基菌
<400> 85
Met Leu Ala Trp Trp Val Ala Phe Leu Phe Arg Phe Asn Phe Asp Ile
1 5 10 15
Pro Ala Pro Phe Ala Glu Ser Met Leu Gln Ser Ala Ala Trp Val Ile
20 25 30
Pro Leu Gln Ala Thr Phe Phe Leu Leu Cys Gly Leu Tyr Arg Gly Val
35 40 45
Trp Arg Phe Ala Ser Leu Pro Asp Leu Gln Arg Leu Ile Arg Ala Ile
50 55 60
Gly Val Ala Ala Val Val Val Val Ala Ile Leu Phe Met Phe Gln Pro
65 70 75 80
His Gly Val Val Pro Arg Ser Val Leu Ile Met Asn Pro Met Leu Leu
85 90 95
Leu Leu Leu Met Gly Gly Ser Arg Ile Ala Tyr Arg Ala Trp Lys Glu
100 105 110
His Arg Leu Tyr Gly Ala Ala Gln Ser Ser Gly Lys Pro Val Leu Val
115 120 125
Leu Gly Ala Gly Asp Ala Ala Ile Ala Leu Leu Lys Asp Leu Ser Lys
130 135 140
Ser His Glu Trp Arg Ile Val Gly Leu Leu Asp Asp Lys Gln Ser Met
145 150 155 160
Phe Gly Arg Glu Leu Leu Gly Val Lys Val Leu Gly Lys Leu Ser Asp
165 170 175
Phe Pro Glu Ile Ala Lys Ala Met Ser Val Gln His Val Ile Val Ala
180 185 190
Ile Pro Ser Ala Arg Asn Asn Ala Gly Ala Arg Leu Leu Ile Trp Pro
195 200 205
Val Ser Thr Asn Ser Arg Tyr Leu Pro Cys His His Trp Lys Ile Val
210 215 220
Gly Val Ser Ala Trp Arg Ser Tyr Val Arg Leu Arg Leu Lys Ile Cys
225 230 235 240
Leu Gly Val Ser Leu Trp Cys Trp Thr Met Met Val Cys Thr Ser Ser
245 250 255
Ile Val Arg Trp Leu Trp Ser Leu Ala Arg Ala Ala Arg Leu Val Gln
260 265 270
Asn Phe Ala Asp Ser Tyr Ser Ser Phe Ser Leu Gln Cys Trp Cys Val
275 280 285
Ser Thr Ile Arg Ser Phe Leu Phe Ile Ala Ser Lys Asn Pro Leu Ser
290 295 300
Trp Met Cys Gly Leu Asn Ile Trp Gly Thr Ser Arg Met His Asp Ala
305 310 315 320
Cys Ser Thr Cys Leu Leu Val Ile Ser Gln His Ser Ile Ser Cys Cys
325 330 335
Ser Leu Thr Cys Ala Tyr Asp Gly Lys Pro Arg Cys Arg Val Ile Ile
340 345 350
Gln Cys Ala Gly Tyr Phe His Ser Ser Gln Cys Met Gly Gly Gly Arg
355 360 365
Val Cys Ala Gly Ile His Arg Ser Gly Pro Asn Gln Cys His Gly Gly
370 375 380
Gln Thr Ser Gly Asn Gly Val Ser Arg Phe Ala Gly Gly Asn Arg Asn
385 390 395 400
Pro Leu Cys Gly Ser Ala Phe Arg Gln Cys Ala Gly Gln Gln Trp Cys
405 410 415
Asp Pro Val Arg Ala Asn Cys Ala Trp Trp Ala Ser His Arg Tyr Ser
420 425 430
Ser Arg Asp His Ala Leu Phe His Val Tyr Thr Gly Val Pro Val Gly
435 440 445
His Ala Ser Arg Ile Asp Gly Gly Arg Arg Asn Ile Arg Ala Arg Tyr
450 455 460
Gly Pro His Gln Asp Cys Gly Leu Gly Ala Cys Tyr Asp Val Val Arg
465 470 475 480
Val Gly Gly Gly Arg His Cys Phe Phe Arg Pro Ala Pro Trp Arg Glu
485 490 495
Ala Val Arg Gly Thr Phe Gly Arg Arg Arg Thr His Phe Thr Asp Ala
500 505 510
Ala Arg Ile Ala Tyr Arg Arg Gly Lys Cys Arg Gly Leu Gly Cys Gly
515 520 525
Phe Ala Gln Val Gly Arg Gln Val Ile Gln His Gly Gly Ser Arg Glu
530 535 540
Ala Arg Ala Gln Asp Val Gly Gly Gly Val Cys Arg Tyr Thr Cys Ser
545 550 555 560
Phe Phe Cys Val Asp Ser Arg Val Ile Asp Asn Thr Leu
565 570
<210> 86
<211> 291
<212> PRT
<213> 糖原甲基菌
<400> 86
Met Thr Lys Lys Ile Thr Lys Ala Val Phe Pro Val Ala Gly Leu Gly
1 5 10 15
Thr Arg Phe Leu Pro Ala Thr Lys Ala Ser Pro Lys Glu Met Leu Pro
20 25 30
Ile Val Asp Lys Pro Leu Ile Gln Tyr Ala Ala Glu Glu Ala Val Ala
35 40 45
Ala Gly Ala Thr Glu Leu Ile Phe Ile Ile Gly Arg Asn Lys Arg Ser
50 55 60
Ile Pro Asp His Phe Asp Lys Ser Phe Glu Leu Glu Ala Ser Leu Glu
65 70 75 80
Ala Ser Lys Lys Thr Lys Met Leu Glu Glu Ile Gln Asn Ile Leu Pro
85 90 95
Lys His Val Ser Cys Ile Tyr Ile Arg Gln Ala Glu Ala Leu Gly Leu
100 105 110
Gly His Ala Val Leu Leu Ala Lys Ser Val Val Gly Asn Glu Pro Phe
115 120 125
Ser Val Ile Leu Ala Asp Asp Leu Ile Asp Ala Glu Lys Pro Ala Met
130 135 140
Gln Gln Met Thr Glu Leu Phe Glu Lys Gln Gly Ala Ser Ile Leu Gly
145 150 155 160
Val Glu Asp Val Glu Pro Ser Glu Thr Ala Ser Tyr Gly Ile Val Asp
165 170 175
Ala Val Glu Leu Thr Gly Pro Asp Val Leu Gln Leu Asn Gly Ile Val
180 185 190
Glu Lys Pro Gln Pro Glu Asp Ala Pro Ser Asn Leu Ala Val Val Gly
195 200 205
Arg Tyr Ile Leu Thr Pro Glu Ile Phe Thr Cys Leu Glu Asn Val Lys
210 215 220
Pro Gly Lys Gly Gly Glu Ile Gln Leu Thr Asp Gly Ile Ala Ala Leu
225 230 235 240
Met Glu Gln Gln Lys Ile Leu Ala Tyr Arg Phe Lys Gly Lys Arg Tyr
245 250 255
Asp Cys Gly Ser Lys Leu Gly Tyr Val Lys Ala Asn Val Glu Phe Ser
260 265 270
Leu Lys His Glu Glu Ile Gly Glu Glu Phe Ser Gln Tyr Leu Arg Glu
275 280 285
Leu Thr Lys
290
<210> 87
<211> 774
<212> DNA
<213> 鞭毛甲基菌
<400> 87
atgtccttaa ataaaaactt aaacgatatt gagaaaagcc agttaattga gctaatgcat 60
gaatctttga gaattcgctc gcactttgag ctttttctct ggatgcaggg aaaacttcag 120
gttttcctgc cgcatgaaat catgataacg gcttggggag acttttcact tggagtcata 180
tacttcaaca ttgtttcccc cctgccaggc atccgctccg acaagattgc cagtcatgaa 240
atcaatcagt tcctgcaaaa cctgttcaac tattggctga accatgccaa ggcccctttc 300
acgctcgcag cagccgacaa catcctgcat gactgcgaat tctctaacaa agaatcaagc 360
tattacttaa aaaacatgaa atcggcattg gtgcatgcca tcaaggatca ccgtggcagg 420
catgattgcc tttatgtatt gcttagctcc aacctgagct tccccccagc ctctcgtccc 480
atgctggaag cgcttctacc ctatatcgat agcgcattgc ggcagataga acacttgccg 540
gagcagcaac cgacactgat caaggcagaa cccgagccca aggatgaaag cctgaatatc 600
ctttccggcc gcgagctgga gatcatggac tgggtcacca aaggcaaaac caaccaggaa 660
attggcatga ttcttgatat cagcgccttt actgtcaaaa atcatttaca gcgcattttc 720
aaaaaactca atgttatgaa tcgtgcacaa gccgtcgcca aattccgcaa ataa 774
<210> 88
<211> 507
<212> DNA
<213> 鞭毛甲基菌
<400> 88
atgtatcctg atctggtgca tctgggcggt gcggataaat atttcgagga aatcctcgag 60
attgtaaata aaatcaagct gttcggggac ttttccaacg aggaagtgcg ttatttgtgc 120
tcctatatgc agtgctatgc tgcacccagg gactgtcagc tgctgacgga gggcgatcca 180
ggagattact tgctcctgat cctgacggga gaagtgaacg tcatcaagga tattccgaac 240
aagggaatac agaccattgc caaggtcggg gctggcgcca tcattggtga aatgtcaatg 300
attgatggca tgccgcgctc tgccagctgt gttgccagct tgcccactga ctttgccgtg 360
ctgagcaggg atgcgctata tcaattgctg gccaatatgc ccaagctagg caacaaggtg 420
ctgatcaggc tgttgcaatt gctcactgca aggtttcgtg aaagctatga caggattctc 480
cccaaaaccc tgggtgagtt gatctga 507
<210> 89
<211> 678
<212> DNA
<213> 鞭毛甲基菌
<400> 89
atgtttttat cccgtttaca tacgccgatc ctgagccgtg tagcgccatt tgcattgtat 60
atgctcttca tggcagtggt ggacttggta gtccggatcg gcttggtgga cgccgatacg 120
cgttggctct atggcatcaa ggtcgggctg gtcgccctat tgctttggta tctacgcaag 180
cagtatgtcg agctccaggg gctagccgcg ctgggagcca ggtcgtggtt gagcgcaatc 240
gccgttggta tgctagtatt tatcgcctgg atcaatctgg atgcgccatg gatgttgatt 300
ggcgatcaat ccgaagggtt cgatccggga agcggaccgg atgcccgtct gctgatggcg 360
acaagagtga tgggggccgc attggtcgtg cccttgatgg aagagctgtt ctggcgttca 420
ttcttgatgc gctggattca caaccaacat ttcctcaatg tcgaccctcg gcaggtaagc 480
gtcctggcct tactagtttc atccgcattg tttgcaatag aacataccga atggtttgcc 540
ggtttagtgg ctggcttggc atacggcttg ctttatattc gtagcggaaa aatatggttg 600
ccgatcatcg ctcatgcggt gacaaatggc atattgggac tttggatcat atataccggt 660
aactggcatt actggtaa 678
<210> 90
<211> 1233
<212> DNA
<213> 鞭毛甲基菌
<400> 90
ttgcggttat ctcaatcaac taacctaata aaaattgctt tggtcgctgg gctaggtatc 60
gagcttgctg gatttgtagt ccctgcttgt gcattagagg gggatgtttt aaagccgtat 120
gccagtctta catattcata tgatgataat ttaagaagat tcgctagtaa gcaattagct 180
caaatgagta ctgggagttc agatacctca gatacaatgc ttgtcaaaag cgctggtatt 240
gtgctggatc atactattag tcgtcaaaaa atgtatgtgg attttagatt aaacaagtcc 300
acatttaata aaaactcaga gttagataat gatggtcgtg acgttattgc caggtgggat 360
tgggagttgg gaaatcgatt ggaaggcaag gttgagtttt ttcataaaaa agctttggtt 420
cctttttcag aattccaacc tctgcaagga accatgttat cgttaaacac aagaactcag 480
gaccgccgct tattggaggc gcgttggatg ctgcatccta gatggcgtgt tagaggggct 540
tttatttact ctgaaatgga gtacggggct gaggctcaaa gggccgctaa tctaaaggaa 600
gatatacagg agatcggatt tgactatcta tctcctacta aaagtatcat cggtgttctg 660
tacagaaata ctaaaggatc aaagccgcag caagcttttc agggatcttt tataagcaat 720
gattatgacc agaatgaatt aaagttgaat gtcgattggg ctgttaccgg aaagtcaagg 780
ttgcagtttc ttggtggttt ggtagatagg cagcatgagc aactgtctca acgggacttt 840
aggggggtta atgctcgggg aaactttaat tggatgactt ctggaaaaac caatttgaat 900
gctgcagttt ggagagaaaa taacgctcag tcatttgtta caacaagtta tacgctgaat 960
cgtggaacat cattaacggc taatttgcag gcaactggta agatagctgt tcaaggcgta 1020
ttgaaatatg aaaaaagaga ttttgagggg gatcaaattt ttggtcaatt taggtcagat 1080
aaagataaga gttttatgct gtcacttatg tataacccag taacatcttt taggataact 1140
acttcattta ttcatagtga tcgagagtca acatctgata tgtttgaatt taggtcaaat 1200
agtgtctcag taacagggca atatgagttt tga 1233
<210> 91
<211> 1386
<212> DNA
<213> 鞭毛甲基菌
<400> 91
atgacggtaa atgacatacc tttagtcgct tttttcaagc agctgttaga tcctttaatt 60
attctgggga ctttgtatgg ctttacgctt ctttatggtg agccattcaa tggctactac 120
ttaatccttg cgttgcttgc atactttgta tcttcaaatg tctatgagcg cctggatctt 180
taccgcacat ggcgtagtgg aaaagtgttg ggctatattc gtgatatttt gttcggatgg 240
gcaattgttg tcaccatatt ggcatttatc ggatatgccg cagaccttac tgatcagtac 300
catgaggaaa tggtgtatac ctggtttgtg gcggtgccga tcatctttac tgttgcgcat 360
ttgctcatcc gcaaaattgc ctcggatttg cataaaaatg gcgaagttcg ttctgttgtc 420
atagtaggcg ctaatgatat cggtgtccgg ttggtgaatc gcatcaatga agacccttac 480
ctgttcatgg aggtgaaagg tctttttgat gatcgcgaga tatcccggca tcccaaggga 540
atgcgtcatg taccgttgct aggcacaatg gcggacgtgg cggcttatgt gcgtgccaac 600
aatacccaga tcattttcat cagtctgccg atgtccgcgc aaccgcgcat cagacagttg 660
tttgaggagc tgcaagacac gacagcatct gtctattttg tgcccgatat ctatattttt 720
gatctggtgc aggcaaggtt tgatgatgtg gcgggtgtgc ctgtggtggc gatttgtgaa 780
acgccgttta cagggtttaa tagcttaatc aaacggacta gtgacattat tcttgcatcc 840
cttatcctgt tgttgctttc accgatcatg ctgacactgg ctttggctgt gaagctgact 900
tctaaaggcc cggtaatatt caagcagcgt aggtatgggt tgaatggtga ggaaatcatt 960
gtttacaaat tccgctccat gacagtgatg gaagatggtg acaaagtggt gcaggcacaa 1020
aagcgtgacc agcgcctaac accgattggt ggttttctca ggagaaattc ccttgatgag 1080
ttgccacagt ttatcaatgt gttgcagggg cgaatgagta tcgtaggccc gaggcctcac 1140
gccgtggcgc ataatgaaca ataccgcaag ctcatacgtg gctatatgtt gcgccacaag 1200
gtgaagccgg gaattactgg ctgggcccag gtgaatggat tgaggggtga aaccgatacc 1260
ctcgaaaaaa tggaagcgcg gattgaatat gatttggatt atctcaggca ttggtcgctg 1320
gcgttcgatc tctggatcat catccggacg gtgctggtag tgtttaaaaa agataatgcg 1380
tattga 1386
<210> 92
<211> 945
<212> DNA
<213> 鞭毛甲基菌
<400> 92
ttgaatactg aatatggaag cacaataatg caatggtcga aaatgacgaa aggggcgttg 60
gtcgccttga tgattagtat cgggctgtcg ggctgtggag ataaatctaa tgaaacaaag 120
gctagccaat cgctggcgag agtgaacggc aaggaaataa ccgtccatca actcaatgaa 180
gagcttgctc gggccaatgt ccagccagcg cagaaagaag ctgctaccaa gcagatattg 240
caatcattga ttgaccgtca actgttggag caggctgcct tgaaagcaaa agtagaccgg 300
gacccgaacg tcatgcaagc cattgagcgc gcaaaatccc aaatgattgc ccaggcatac 360
ctccagtcta gggtggctaa cataggcaag ccggacaaaa cagaagttga gaatttctat 420
aagcaaaacc ctcaactatt ttccgagcgc aagctggtgg aaatggaaca aatattgatt 480
gattcacgtt atgtcaatga cgaattcaag tctgcgctcg gtagcttcaa aaccctgcag 540
gaagtcgctg cgtggttgga tgctaaggga atccaatatg accgtggaga agttgcccgc 600
agtgtggcag agctgcctcc acagatttct gagcgcctga aggatgcaag gcgtggccag 660
ctgtttgtga tcggcatggg accgaggacg atgctggtgc tcatggatag cgtaaaggag 720
agcccggtat cactggcaga tgcgacaccg caaattgagc aaatgctctt gaataaaaag 780
cgtaaggaag cgggtgaggc tgaaatcaag cgactacggg ctgaagcaaa aattgaatat 840
ttagacaaat cggccgaagt accacaacaa ccagaaaaag ccgaacagtc aaaaccctct 900
agtgtcgatg atgatattgc tcgcggagta agcggactaa agtag 945
<210> 93
<211> 813
<212> DNA
<213> 鞭毛甲基菌
<400> 93
gtgtataggt gtagtgccat gactaaattg atcaaatggt ttgtaacggt agtcctgacg 60
attgttgtat tcaatgttaa cgcagcggat tcggatattg ttcttgggcc gggggatgtt 120
ctaaggatat ctgtatttga acagcctgat ctttccttgg aagtaagagt gagtgagtct 180
ggcactatca cctacccgtt gataggcgaa gtcagagtcg gtggagaaac acctgcagct 240
gctgaacgca aaattgccag catgctggaa agcggtggat tcttgaaaaa ccctcacgtg 300
aatatcattg ttgctcagtt gcagagtcag caggtttctg tgctaggtca ggttaacagg 360
ccaggtcgct acccactgga tagtgcaaaa tctcttgcag acgtactggc gttggccggt 420
ggagttgcac ctgatggggg agatttgatt agcttggttc gcaagattga ggggaaaagt 480
gttagagaga taattgattt tgctgaaatg atgcgggatg gcgacttaaa taaaaatatc 540
ttacttacgg caggagatat tatttatgta gatcgagctc ctagattcta tatatatggt 600
gaggttcagc ggccaggaca atatcgtctt gagtatcata tgacagtgct gcaagcactc 660
gctgttggtg gtggccttag tctcagggga acggaaaaag gtattaaggt gaaacggtta 720
gatgatgaag gtggtgttaa gataattaaa gtaaagcatg atgattttat tcagcctaat 780
gatgttgtat atgtacaaga gagtgtattt tag 813
<210> 94
<211> 1410
<212> DNA
<213> 鞭毛甲基菌
<400> 94
atgagtttta tcagatttat ttctatcatt aaagctagat ataaaattat tatttttact 60
ttatttataa cggtattaac taccgctatt gttacaatat tgttgccaaa aaattataaa 120
gcaacagctt cagtgcttgt taattataaa ggcgctgatc ctgtaacagg tgtaatgctt 180
cctgcgcagt taatgccagg ttatatggca acgcaagtgg atattatttc aagtaaaaac 240
gttgcaaaaa aggtaattga taaactaggt ctggcagatg ttccagccgt aaaagaggac 300
ttttatcaag caacttcagg taaaggtgaa attaaagaat ggcttgcaga tttattgcta 360
aaaaaacttc aagttaaacc atctcgagag agtagtatta ttgatattag cttttttggg 420
gtaaatcccc agtttgcagc tacaatcgca aacgaatttg ctgagtctta tatgcaaact 480
tcaatacaac ttaaagttga gccttctcaa aaagctgctt tgtatttcgt tgagcaattg 540
aaagaactga gagaagatct agctcaagcg caatcgaagc tttcagagta tcagcaagag 600
aaagggattg taagtgttga tgaaagattg gatgtggaaa gagccagatt aaatgagctt 660
tcatctcaat tggttattgc acaagcacaa gttatggaag cgagatctcg ggaaaaaaat 720
tcaagtggaa aagaagctta tgagtctcct gatgtagcag ctaatccaat tatccaaaat 780
cttaaaactg aaattgctag agcagaatca aggtttgcag atgtttcgca gaaatttgaa 840
agaaaccatc ctttttatct aggagctaaa gcagaaattg aaaatcttaa gtctgagcta 900
gatagacaga tcaaatcggt ttcaagtaat gtggcaagta attcaagaat tctgcaacaa 960
cgtgaagcgg aaatacgttt ggctttaaat aatcaaaaag aaaaagtatt acaacttaat 1020
cgagataggg atattttatc tgttttgaca agagaggttg aaaatgctca aaaagcatac 1080
gacatggcta tgcaaaggta tactcaaacg aatattgaag gtcagtcaaa tcaatctgat 1140
atttctttat tgaatcctgc cgtggcacct cttactccca ctagcccaaa tttattgctg 1200
aatattatat tgtcaatcct cttgggtatg tttttaggaa tagggtttgg agttttagct 1260
gagtttgttg atcgaagagt acggactgct gatgacttaa ttgaagtatt acaagcccca 1320
cttcttggga ctattagtaa agaaaaaaga aaactgagat tttttaaaaa tacttcaaac 1380
ctgataactt tagggaaggc tgaattatga 1410
<210> 95
<211> 897
<212> DNA
<213> 鞭毛甲基菌
<400> 95
atgatttcat ttacaccttc taattcaaac tctgaaaaag tagaaaatgc accattggta 60
aacgaatttt cagaatttac aattggtagt ttattattgc ggatggggaa aattacaccc 120
gaagatgctg aaagaattat gcggttacat aaagagaagg gtttgcgctt tggagaagct 180
gctcaagcat tagggttgat aactgaagat gatattcaac aggttttatc gaggcaattt 240
aactatcctt atttatcacc tgaccaaaac tcatatctta atgagctcgt tgctgcatat 300
cagcctttta gtaacaaagc tgaggttttg agagcagtac gcagtcaatt aatgctgcat 360
tggttttcac cggaacgaaa agcactagct gtttcttcag taagcagcag cgataatgca 420
agctcttttg ttgcaaatct tgcagttgtt tttgcgcaat tgggtgaaaa tacattattg 480
attgacgcta atttacgcta cccacgccag catgagatat acaatctgag taacaaacgt 540
gggttatctg atatcttagc aggaagagcg gggtatgatg taatttcaaa aataaatttt 600
tttgaaaact tatctgtatt aactgccggt acattacctc ctaatcctca agagcttgtt 660
agcaagccaa cattcggaaa tttaattaaa gagttggctt gtgtttatga tgtaatttta 720
ttggatactc ccgaacttag taattattca gatggttatg caattgcttt tactgttgga 780
ggaattgtat tagttgcaag acaaaatcat actcgagtga atgatttatc tattgctgta 840
gaacaatgca agaataatgg tactaaggta attgggtcaa tattggttga tttgtag 897
<210> 96
<211> 888
<212> DNA
<213> 鞭毛甲基菌
<400> 96
atgaacactg tcgaggtaat cgagcaagat aatcctggta tctgggaggt aatcaatcgg 60
aattggatgc tattattagg tttgttcatt atgtatacgc ctacatattt gaacttatta 120
aatactgtat ggcaatctga agatcaagct catggaccat taattgttgg cgttgtcttg 180
tatttagtat gggtacagag acaccaattg tttaaggccg aaaataatat tataggcagg 240
ccagtaattg gcgggatagt tttagttttt ggtcttttac tctacattct tggccgttct 300
caagatattg caccgttaga tattgcatct caaattcctg tttttgctgg attgttgcta 360
attttccgtg gttattctgg gcttcgagca ttgtggtttc cgttattctt cttgattttt 420
atggtgcctc ttcctggagt ttttcttgat gctgtgacat taccaatgaa gattgcggtc 480
tcatatgtag cagaaaatat actttattgg ataggatatc cgatttcaag aagtggggtg 540
atcctccaaa tcggacaata tcaattactt gttgcggatg catgtgctgg tttgcacact 600
ttaatatctt tggaggcgct gggtttactt tatttaaatg ttgtaaagca cgattcattt 660
attcgtaatg taattcttgg gatattgatt attccaattt cttttaccgc taatgtgatt 720
agagttatgg tattaacttt agttacttat cattttggag atgctgctgg tcagggtttt 780
gttcatggtt ttgctggaat gttacttttt gtagtggctc taattttgat aattagtgtt 840
gatacgctcc tacaatattt ggttaaaaaa tggcagttaa aagcctaa 888
<210> 97
<211> 681
<212> DNA
<213> 鞭毛甲基菌
<400> 97
atggatggat ttacactgcg aaatttaatt atatttttac tgttattggt agctacttta 60
ggaggagtaa ttcttaaacc tactaagttt gttaatgcag cagaagatat aaatttagaa 120
gcaatgattc ctaaggagtt cgatgagtgg aaaatcgatc ctacgattac tcctatacaa 180
gtgagccctg aggtgcagca aaacctcaat aaagtttatg atcaaactct ttctcggacc 240
tatattaata agcaaggaat gcgaataatg ctttcgattg cttatggggg agaccaaagt 300
cgcggcttgc aagcacataa gcctgaaacc tgctatacag ctcaaggatt taatgttgat 360
ttgttgggta atgccatttt aaattttgat ggatatgaaa ttaaagttag acatttatta 420
gcccagcatg gggcacgata tgagccaata ctttattgga tgcgtgttgg tgaaactaca 480
gtttatggtg gattgggtca aactataaaa aggtttgaat taggtttgca gggatatatt 540
cctgatggac tgctttttag agtttcaagt attagcagag ataatatctc tgcttttaca 600
ctgcaagaag aatttgttaa atctttactg aaaaatgtag atagtaaaag tagaaaaaaa 660
cttataggta cattttcata a 681
<210> 98
<211> 1287
<212> DNA
<213> 鞭毛甲基菌
<400> 98
atgattaaac ataccgcatt tatggctctt tcgacttttt cacggttgct atcagcggtt 60
gtacttttca ttattcttgc aagattcctt ggtccgagag actttggcat attgatgtac 120
aattttactc ttgcgtcaat agctgtgctt ttagtggaat atggattttc aaatcagttg 180
ttaagagata taggaagata ccctgataat attaatcagt taatggggag ggtttttctt 240
gcaaaactat atctcacagt agtgatgggg gtctgttgcc ttgctggaca ttacttattc 300
tatacaaatg acttagatag agcaatattt tggattttac tgttatcttg tttgctcact 360
tcttttgggg atttttttaa tattgcattc agaggtatcg gaaaatttca tgaagaaaca 420
aaagttgcaa caattggctc tttgttgcat ttcggcttaa tagttttaat ggtaattaat 480
ggggctgagt tattattaat tagtttaggt tttgttttat ctcgttttgt ttattttatt 540
ttgtcgtggc gggcatataa gcgagtggtt ggtgatttaa atactctgtc agcctctcca 600
gttgctgttc taaaagcatt aaaagcagga tttccatatg ccgttgatgc gggtttcact 660
aactttttct accaagttga caccatgctt gtgaaatatt atctgggagc cactggagtt 720
ggtatttacc aagcaggtat gagatttcta aatggtgcaa tgcaatttgc acctgtactc 780
ggaaatgtat ttttacctgt aattgctgcc aagcacacta atactagaga gtttgttgag 840
ctagctaaaa aacttaatct tcagatgctt gctgttggta ctgtgtgctg ggctattttc 900
tggtttgccg gtatgcatat taccgaattt gtttttggtg atgaatatgt agagttaaat 960
tcaatttggc cctatattgg tttgttagtt tttacaagat atcttgctgc gcctcaaggt 1020
gttctattga ctgcttctgg atctcagaca atacgtgtct gggcacaaat ttttgcactt 1080
attattttgc taatttcagc accacttctg atgaaagtga ttggactaaa aggtatggtc 1140
attgctttaa tcatcacatt attaaccttg tttttgatat ttttcagtgc attacggctt 1200
agaaaaatac ctactgggtt tgggggagtt aattttactt tgactgtaat agtatttagt 1260
ctttccattt ttcttttggt atattag 1287
<210> 99
<211> 1179
<212> DNA
<213> 鞭毛甲基菌
<400> 99
atgttgaaaa taggcttact ttggcattct actacttcag ataatcttgg tgttggcgct 60
ttaactgaag cacaaatttc tattattaat aaagctgcgg tgcaggcggg ggttgaggtt 120
gaatatcgaa ttttcggcac taatggaaac aaagattact ttgagggcaa ccctttaatt 180
gagcgaggga caaatgtatc actcaaaaga attttgatcg gggcttctga ttatcccaag 240
aaaatccggg aatgcgatgt ggtgtttgat ataggtgaag gtgatagttt tgctgatatt 300
tatggttttt cacgattcct aatacagatt gtgtctaagt tggttgtctt gtttcaacgt 360
aaacctctta ttttaagccc gcaaactata gggccattcg aaagtaggtt taatttaaag 420
gtggccaata atgtaatgca gcggtgcact aaaatatttg taagggatgg attgtcattt 480
ggatacttgc aaaagaataa tttatctgta aatgcagagg aggtaattga cgttgctttt 540
agattgccat ttcaacgccc ttcccgggat tcaagtaaag taaaaattgg actaaatgta 600
tcaggattac tttataacgg tgggtatact gggaagaatc aattcggtct tagtgttaat 660
tatcctgaac ttactagatc actattagat cagtttactc gaatagaagg ttgtgaagta 720
tggcttgttc ctcatgtgct aacgacctca tttcctatag aagacgatgt gaacgtgtgt 780
gttcaattac aagagcttta tccagctgct aagcttgcac catctttttc ttctcctagc 840
caagctaaat cttttatttc agggatggat ttttttcttg gagctcgcat gcatgcttgt 900
atcgcagcat tttcaagtgg agtgcctgtt gtgccattag cgtatagtag gaagtttaat 960
gggctttttt ctgccttgga ttatccttat cttggggatt gtaaggttaa tactaacgag 1020
caaatagttg gtttggttat ggattgtttt aacagtcggg agcagttgaa gtttgcagta 1080
gaagaaggta ataaaattgc agaaaaaaaa ctattgcgtt atgagcagta catagcagaa 1140
ttattaacta gaatttcaaa taaaaagatt gttttataa 1179
<210> 100
<211> 1023
<212> DNA
<213> 鞭毛甲基菌
<400> 100
atgtatagtt gtaagatgaa aaaatacata attggtttct tgccgctttc tattaaatgg 60
cttctgagat tttgtcttcg aggcccgagt ttattgagag acttttgtta cgatgctaaa 120
cgatatatta aatggtcatc tgtaatttct ttcgagaaag atcgtgaaaa gattcttgcg 180
gttattactg ctacttatca caacatcgag aaaggaatgt ctttacctaa tcccaggccg 240
ttatttggaa gggtagtgat tggacaatta gttggatcag tcgataattt tcatcttaat 300
tttgggcctg atccacagct agatgttccg ataaatgtac tggcgcgtta ttgtcaattt 360
aatagaagtc ttggtcagcc agattctcaa ttagaagtaa tcgttgatcg gttaaagaaa 420
aataatcaga gcactttatt aaggattaat gatggcgggg ttattttgcg ctctaaagct 480
gaggttttag acgcaatatc tggggttaaa gaagattttt ttcttatgcg ccatagtgta 540
aggcagttca ctaaagatcc tatagagcat agtgtaattg aaaaggccgt acgtattgct 600
caaaaaagtc cagcagtttg taatcgacag tctggaaagg tccgggcaat tcttaatcca 660
gaattaatta ggagtacttt acaaattcaa gggggcgcac gagggtttta tgaagaggtt 720
caggctttat tttgtataac agtggatttg tcaaatttta atggggcgga acgttatcaa 780
ggttggattg atgggggaat gtttgcaatg agttttatat atggcttaca tttgcaaggc 840
ctaggaagtt gcgctcttaa ctggagtaaa actaggaaac aagatataga aatgaggaat 900
caccttcgta taccagaaaa cgaattaatt atcatgtttg ttgccgctgg atatttaagg 960
gaatcatttg ttgttccgca atcataccga aaacctttag gtgaagtctt gagttatatt 1020
taa 1023
<210> 101
<211> 1473
<212> DNA
<213> 鞭毛甲基菌
<400> 101
atgaagaaca attcttctct cttatctttt aaccgtaggg atgctaattt cgttagttta 60
aagataggga gtatattttt tgtaataatg gctgcaatag tggctttgat atttggtttt 120
gtcagtgcta tttttccatg gtggtggata gtagccatta ttctttctat attatttatt 180
tttattggtt ttacatatcc tttagtagct ttaatagctg ttatagcaat ttcttctaga 240
ttaattccag atacattttt gccttcaata agactgctgg gaggcacaat accatcttca 300
gatatggcct tgtttgcaac attcattttt tgttttttta aatacaattc agaatttagc 360
tttacaaagc aagcattgtc acctttggct attcctttat ttgttgtact tttactgttg 420
cttttttctg tatttcgggc ggtgtttgaa attagattgc cattgaaaga tattttaggg 480
gagtcaaggc atttccttta ttggctattg attcccttaa tagctttaac atgctcagat 540
agacaaagat ttaaatttat tgtttttggc tttctttttg tagctttttt attttcaatt 600
ggccagattt tgcaaggttt tctaggtgta aatgtgttcg ggcgcgagct tactagcctt 660
gaaactttgg gaagcattaa tagtgatgtt acacgaagca tgacgtcagg aactcacatt 720
attgtttggg gatttttgtt tgtactggct ttgtttgcta accgaatagg tttttcaaag 780
actcttatta tattgtgtat atttacaggc gctggaattt tcttaaccta tggtcgtgct 840
gtttgggggg ggactttctt agctgttttg ttcttatgct ggaagctagg gacaaaaaaa 900
atgcttagaa gtgtaggact aattgcaatt gttgctgtat ttggtttaag tgctatgcta 960
gctattaagc cgggcgctat tgaaggcgcg atgcagagat tgtttagtgt ggaggaggag 1020
gtttctcatg gatcttctct cggctggagg ttttatgaaa ataaaatggc atgggcggca 1080
attcagcggt cacctttatt aggcattggg cttggtgccc cttataggcc gcctgctaaa 1140
tctgatgtga cagcagagca agtgagatat gttcatagtg cttatatcta tttaacctta 1200
aaaacaggca ttattgtatt catgtcagtc atttttctta tattcaaaat acttcattta 1260
acttacattc aaacgcggtc taatgattta tttatatcaa gtgttgccat agcttctttt 1320
gctgcaatga tagagtattt tttggcctgc attactcagc cagaattaat gcaaaccccg 1380
ggaattgctt ttttggctac tcttgctggt cttatgtgcg cggctaatta tcttaatcaa 1440
aaaaatctta caaaaggaaa gctaacttct taa 1473
<210> 102
<211> 807
<212> DNA
<213> 鞭毛甲基菌
<400> 102
atgaatgtta aaacatctcc attaattagt attattacgg caacatataa ttcaatgaaa 60
tattttgagg atactaaaaa aagtgtcctt gaaggagatg ttgaagactt tgagtggatt 120
atcgttgatg atggatccac tgatggaacg cggaaatatt tacaagaaat tgatcatcca 180
aatataaaat tgcattttaa aagtattaat gctggtattg aagactcata tagaactggt 240
attgaattgg cgaccggtaa atatttgcta attttagatc acgatgacac tattccattg 300
ggatctttgt caaagcggct tgacttactg gaatcaaatc ccaatgcttt ggctgcattt 360
ggtgctgtgg catatatgga tgagtctggg aggatttata aagaatcacg ttttcctttt 420
gtatcagatg attgcgtact gtcatcacta tttactttat tcggaatctt tattttacca 480
gtataccctt taaagcaagg gtgtgtggtt ttgaggtctt ctttcgttaa aaataatcca 540
gggttatatg acatacaact attcctgcaa gctgctaaat tgggcccagt aatatttatc 600
aagcaagcat gtttaaatta tcgaacattt agaacgcagt tttcaagttc tagaaaaatg 660
cgattgattc gtttttttca atttgtttgg gcaaaatatg cgtttaaatt tctcccgtgg 720
tatataagcc cgttctttgc tatttataaa acaataccag agttctttaa agtattatgg 780
agttttgttt cttcaaaacg gatttaa 807
<210> 103
<211> 969
<212> DNA
<213> 鞭毛甲基菌
<400> 103
ttgatgacgg attttagttc aaaaaaaaag ttagacttaa gtgttgcaat agtttttgtt 60
aattataata ctagtgacca aattatttct tgtatttact ctcttaggga agagagatat 120
tcaaagatta ttgttgtgga taatgcatct ccggatgatt gtcctgagtg catcgtagaa 180
gagtttccag atgttgtact tattaaaagt gaaaaaaatc ttggctttgg tgagggatgc 240
aatattggaa aagattgggt tatagttaat acagattgtg aatatatatt ttttcttaat 300
ccagacacac tagttgaacc tggattatta caattactgc atgatggatt ttttagccct 360
gaagttggat tggttacccc aagaattact atgatgggtg atgggttgga tatactttgg 420
tatggtgggg ggtatatgaa ctggttaact ggttcggcac gcgtaccagg ttgtggatta 480
agtgctgtat caaaaatagc tctagaagat cgatttgtag agtttgccag tggttgcgct 540
tttatgatta gacgttcagt tttagaagag tgtggcgggt tcgatccacg ctattttatg 600
tacgaagaag acgtcgaatt atctttaaga gtaatttctt atggatataa aatttattat 660
atgccaaaag ctgttgttcg ccatctggct cagggtagcc agggcaaaga ggtagaggct 720
gttggtatgt ttaaaggaag gaatcctaag cttccttttt ttgtttatca aactgcgaaa 780
aatagatttt taactgtttt tactcatgga actgtgctta agaaaggtct atttttaata 840
ggttttatgt tatgggtgtt tcgaaactct tttgaatggg tcagatataa gagacttgat 900
gcatataatg ctttattttt gggcattaaa gattttgtta aatacacata tgtatcaggt 960
aaaaaataa 969
<210> 104
<211> 1149
<212> DNA
<213> 鞭毛甲基菌
<400> 104
gtgaaagaaa ttaacgtcgc ctttgtggag ccagttggta gtcacggtgg tatggactat 60
tatgattctg gactgtgtgc cggtttgtta catcagggag tatctgcaac ttggtatacc 120
tgtgacattt ctaaaccttg tggtaataga cctattttca tgcaacttac ttttgtaaat 180
atttggggaa aggatgctac gtggagaaga ggggctaggt atatcttagg gctttgtagg 240
agcataaagc atgctaaaaa aaattattca aatattgccc attttcattt ttttcatgtg 300
ggtgttttag aatttttaag tgtattattt tttcgcttat ttggatttaa ggttgttgct 360
acagtgcacg atgttgagtc ttttaagccg ggtctaacct tctctatctt gttaaaatgg 420
acttactttc tctgtaatca attaattgtg cacaatcaag ttagtaagga tgagttgatt 480
aatagaagta atgtttctat aaataaaata catgtaattc ctcacggaag ttatattggt 540
ctggttgcac cctcgatgcc aaaagcagat gctcgtcaag ctcttaatgt atcatcagat 600
gaaaaggtaa ttttattttt tggtcaaatc aaagaagtaa aaggtttgga tttgttgatt 660
gaagcgttag gtttggttaa agataaacta aaaccattta agctagtcat tgctggaaaa 720
gtgtggaaag ataatttctc taagtatcaa gaattaataa gtaaaaacgg gctaaatgat 780
ttttgtaaat tggatattag atacatacca gatcaagaga tatcaatgtt ttatagtgcg 840
gcagacttga ttgttctgcc ttatagaaaa atatatcaaa gtggtgtttt attaatggca 900
atgagttatg gaactccagt gttagcttca gaccttccgg gtatggcgca aattataaat 960
gatggggaaa acggattttt gttttctgct ggaaattata ttgatcttgc tgaaaagctt 1020
gtaaaaattt tttcttacca tgacttatct aggattactt tgcaagcaga aaacgatatg 1080
agaactcgct tcagttggga tgagattgcg ataaaaacta tcagtgttta tcagaaaagt 1140
atatcgtaa 1149
<210> 105
<211> 1506
<212> DNA
<213> 鞭毛甲基菌
<400> 105
atgcaattaa ttaactctcg aaggattgtt ttacttagtt tgttttccct tatgcctttg 60
gttggtattg ctgaagttta taaatctaca gatgtagacg ggagtaccac ttattctgat 120
acccctcaag ctaattcaca aaagataaag gtttttcctt ctgattataa gaagaatgtt 180
aaatctgagg ctgcagctaa taaatccaga agtaattcta tttctgctgc taatgttaca 240
gaagctccta ttgatgagtc tagtagtgat tctaatgtaa ctataaagca ttcaacatct 300
aataaatcta tcaattcaag caatccttct gctgctggtg gctcttcttc tgctggtggc 360
tcttcttctg ctggtggctc ttcttctgct ggtggctctt cttctgctgg tggctcttct 420
tctgctggtg gctcttcttc tgctggtggc tcttcttctg ctggtggctc ttcttctgct 480
ggtggctctt cttctgaaac aactacagct gcttcggtcg ataaggtttc tgcggctttg 540
caaggaccga aagcttttct taattcagac gattttaaag aaaattctta tcgagggttt 600
aatgttcttg ggcggaaatt aagttctgct gacatggaag atcttgaaaa gtttaacgtc 660
aatttaattc gaagcgttat tcatttggaa aaatgtaaaa aatgtaatga ttatgaaatt 720
tctccagttg agttgtcgca aatggatttt cttgtggagg caggtcgtaa gttgggattt 780
tatgtaattt ttgcttttga tcctaaacct gctggagatc aggcgatcta ctggaataat 840
caacaattac gagaaagcat taagaataac tgggtaacta ttgctaaaag atacaaaaat 900
gagactgtgg tggcagggtt tgacctgatt aatgagcctg ttgttaggcc tggatcagta 960
tgggaaaagt atgctactga attgattact gccatacgta aagtagatga aaatcatata 1020
atttttctgg aacctagtcc ttgggggctg gcttctagtt tggagcagtt tactcctgtt 1080
ccatttaata atatagttta cagctttcat ttttattctc cccaagaact tactcatcaa 1140
ggattggcgg catacccaca tgcatatata tatcccagtg aaaagtggga taaagaatac 1200
ctaaataatc gactagacat tgctcgtaat tgggctaata aatataatgt tcctctttat 1260
atcggtgaat ttagcattat tcggtgggct ccgtctggtt cgaggttacg ttacttgaca 1320
gatgtagttg agcgctttga gcaagagaaa tggtcatgga catatcatag ctatagagaa 1380
tatagcggat gggatgcgga aatgccagat agtatattca agaatgatgc tattgtcgaa 1440
cgtcaaaaca atgttcctgt acttcagctt ttgatgaaaa attttaataa aaataagaaa 1500
tattag 1506
<210> 106
<211> 1107
<212> DNA
<213> 鞭毛甲基菌
<400> 106
atgcataaga aaatagcaat attaggaacc agaggaattc cggctgcgca tggtggcttt 60
gaaacatttg cagagcattt ggctatttat cttgaaagaa aagggtggaa agtaacagtt 120
tattgccaag tagatggtaa tgggcctatg tatgaggata tgtggaatgg tataaagcga 180
gtaaatattc cgatatctat ccagggttct ttaggcacta ttctttttga ttggaagtca 240
acgattcatg cttcaaatac ttatcatctt attttaactc ttgggtataa cactgcttta 300
ttctgtgggc tctatagaac taaaggaata actaatctaa ttaatatgga tggaatcgag 360
tggcatcgga aaaaatgggg ggcagttgct aaactctggt tctggattaa tgattgggct 420
ggttcaattt taggcaatca tctgattgct gatcatccgc aaattgcgcg tcatctggaa 480
acaagagtca ggcctagcaa gatcacaatg attccatacg gcgcagataa agtgattgag 540
gcgaatcagg ccgttttgga ggaatatgga cttaagcctt tcagttatgc gatcttaatt 600
gctcgtgcag agcctgaaaa ttctatttta gaggtggtga aagcctggtc cgctaaacct 660
cgaggcatga ggcttgtagt gctaggaaaa tataaccctg accatgctta tcaggtcgcg 720
gttaaagctg ccggctcaga cgaggtgctt tttcctggcg caatttatga taaacacgtg 780
gtcgaatctt tacggtattt ctcaagatta tatattcacg gccaccaagt tggcggcacc 840
aatccttctt tggtggaggc actaggggct ggtaatgcag tattggcgca cgataaccgt 900
tttaaccgct gggtcgctgg agataaggcg gcctactttt ctggtgaaaa ggactgcgaa 960
atcactcttg atgagcttct taatgatgaa gttcggttac gtgagatgag agccggtagc 1020
ttggctcaat acgatacctt atttacctgg gactcagtgt tgcagcaata tgaggccttg 1080
ctgacaaggt ttttgccaaa taagtaa 1107
<210> 107
<211> 1440
<212> DNA
<213> 鞭毛甲基菌
<400> 107
atgcagattc aagccgtgat tttatcaggt ggctctggca caaggttgtg gcctctttct 60
cgagaaaact atcccaagca attgctgaca ttgcttgata atgattcttt acttcagtcg 120
acattacgca gggtcgatcc actcattgga accgagtgtt ctccaattct ggtatgtaat 180
gaagaatatc gctttgttat cgctgagcaa ttgcggatga tgggaaggcg tggatctatt 240
ctccttgagc ctgtaggcaa gaacactgcc cctgcgctca ccttggctgc cttagaggct 300
gccagccacg gccaggatcc aatcttactt gtcatgcccg ccgatcacgc tattatcaat 360
gtgcaagact ttcaggatac cgtgaggaca ggggctgaac atgccgctgc tggtaagatc 420
gtcaccttcg gtatcgtgcc cgatagggca gaaactggct atggttatat caagtcaggc 480
gcagtgctgg aaggtttcgg ttctgctttc agtattgagc agtttgttga gaagcctgat 540
gaggctactg ctcagcaata tgtagtaagt gggaattatt tctggaacag cggtctgttc 600
atgatgcgtg ccacggtatg gctgaatgcg attgctaaga ctcgtccaga tatcttatct 660
tcatgtaagc aggcttggga tggtcaacaa cgcgatggcg attttgttcg ggtggacaag 720
cttaaatttc aacaggtacc tagcgattct atagactatg cggtgatgga gcatgtcgct 780
cgtggtgccg ataatctgcc tgcaggcata gtcatccccc tgaatgccgg ctggtcagat 840
gttggggcct gggattcatt cgggaaaatt ttgccgcagg ataacgcggg taactcccat 900
ttaggagatg tgctgttcaa tgattgctcg aatactctag ctgtgtcttc aggtaggctg 960
cttgcatgtg tgggtctgca aaacatcgcg gtgattgaga cagcagatgc ggtgctagtt 1020
atagataaaa gtaaaactca ggatgtgaaa aaaatcgtgg agcagcttaa ggtccagaaa 1080
aggcccgagg ccaagactca ccgcaaggtt caccgcccct ggggctggta tgacagtatt 1140
gatatggggg cacggttcca agtaaaacgt attgtagtga atccaggtgc tacgttatct 1200
cttcaaatgc atcaccatag agccgagcac tggattgtgg tgaccggtac agcgaaggta 1260
acaagaggag atgaggagtt ccttgtttct gaaaaccagt ctacttatat tcctttaggt 1320
gtgacgcata tgctggctaa tccaggaaag cttcctttag aaatgataga ggttcagtct 1380
ggggcttatt tgggtgaaga tgatattgtt cgcttcaatg atcaatatgg acgttcatga 1440
<210> 108
<211> 921
<212> DNA
<213> 鞭毛甲基菌
<400> 108
atggcaactt tcaacaagat cctgcttacc ggcatcaacg gccaggtagg ccatgctctc 60
tatccgaaac tacaaagctt gggagaagtc gttgcacttg accgcagcca acttgaccta 120
tccaaacctg accatatccg ggacgtagtg cgacagacca aaccagacct cataatcaac 180
cctgcagctt atactgctgt ggataaagcg gaatctgagc cggagctggc ctacgccatc 240
aatggcactg ctcccggcat tctggctgaa gaagcagcaa agctaaatgc attgcttgtg 300
cattattcta cggattatgt atttgatggc accaaaacta ccccttacac agaattggat 360
gaaacaaatc cacttagcgt ttatggagcc agcaagttag caggagaaaa agccattcaa 420
gaagtcggag caaatcatct aatcttcagg accagctggg tttatggtgc atatggaaaa 480
aatttcatgc gcaccatatt gagattagct gccgagcgtg actcattgaa tatagtcgca 540
gaccagtttg gcgcaccaac ttctaccgaa agcattgcag atgcaactat tactgcgctg 600
cacgcatggg atgggactca aagaggtgtc tatcacttag tcaatactgg ggagacgagc 660
tggcatggct ttgcactgga aatcattcgc cagtatggag aaatagccca aaagaaaaat 720
ttagcgaaat taaaatccac tgtagaaaat gttgtcggta ttacaactgc agaatacccc 780
acaccagctc atcgccccgc caactccaag atgagcactg aaaaattcat gagcactttc 840
aaaactgaat tagcaccatg ggaattggct ttgcgatcta cagtaaccca cttagcaaca 900
ttctcggtcg aaaatcatta g 921
<210> 109
<211> 549
<212> DNA
<213> 鞭毛甲基菌
<400> 109
atgaatgtca cgcccaccca tattcctgat gtgatcgtat tcgaacccaa gatattcggt 60
gatgcccggg gattcttttt tgaaagcttc aatcagaaag cctttgagga agccgtcggc 120
aggaaatatg attttgtaca agacaaccac tcaaaatcct caaaaggagt attgagaggg 180
ctacattatc agatccagca agcccaagga aaattggtta gagtagtagc aggtgaagtt 240
tttgacgttg ccgtggatat ccgcaaatct tctccaacct ttggtcaatg ggtagggcaa 300
catctgtcag cagaaaacaa gaaacaaatg tgggtaccac caggttttgc ccacggcttc 360
ctcgtgctgt ccgaaactgc agagtttctc tataagacca cagacttcta cgcgcctgcg 420
catgaacgtt gcctaagctg gaacgatccc gttgttggta ttgaatggcc agatattggc 480
acgcccccgc tcctctcaag taaagatcaa caaggcttag gcctccacca gacagagtta 540
ttcgcataa 549
<210> 110
<211> 879
<212> DNA
<213> 鞭毛甲基菌
<400> 110
atgagaaaag gcatcatcct cgccggtgga tcgggcaccc ggctttaccc tgtcacccag 60
gcagtctcca agcaactgct gcccgtgtat gacaagccca tgatctacta tcccttgtcc 120
acgctcatgc tggctgggat acgcgacatc ctcctgatct caactccgca ggacacacca 180
cgctttgaac agctattggg tgatggcagt caatggggac tcaatattgc ctatgcagta 240
cagccctccc cagatggatt ggcccaagcc tttatcatcg gcaagaaatt tattggcaat 300
gatccaagtg ccctggtgct tggcgacaac atcttctatg gtcatgacct ggcacatgac 360
ctggcacatg ccgatcaacg gcagcatggc gccactgtat ttgcctaccc tgttcacgac 420
cctgaacgtt atggcgtggt cgagttcaac gatgctggcc aggctatcag cctggaagaa 480
aagcccaaag agccaaaatc ccgctatgcc gttactggac tgtatttcta tgacaaccag 540
gtcgttgaca ttgccgccag cctcaaacca tctcctcgag gcgaacttga aattaccgat 600
gtcaacaaaa tttacctgga aaggcgctcc ctcaatgtgg aattgatggg gcgcggtcat 660
gcctggttgg atacaggaac gcatgaatcc ctgctagaag cctcactatt catcgaaacc 720
atagaaaagc gacaaggcct gaaagtcgcc tgccccgaag aaatcgctta ccgcaaaggt 780
tacatcgatg cagaacaagt agaaaaaatt gcccagccat acctcaagaa tggttacggc 840
caatatttga tccggatgct gaaagaaaag gtcttttaa 879
<210> 111
<211> 1101
<212> DNA
<213> 鞭毛甲基菌
<400> 111
ttgacgacat taaataacac tatcattgtc actggtggcg caggcttcat cggtggcaac 60
ttcgtactcg actgggtcaa ggcaggacta ggcaccgtca tcaacctgga caaattgacc 120
tatgccggaa atcttgaaaa cctggcagac attgaaggca accccaacca catcttcgta 180
catggcgata ttggtgaccg cgccttggtc gccaagttgc tggcagaaca caaaccccgt 240
gcagtcatca actttgccgc cgaaagccat gttgaccgtt ccatccatgg cccggaagac 300
ttcattcaga ccaatgtagt cggcaccttc cacttactgg aagaagtacg cgcctactgg 360
aatagcgtgg tgaaaaccca cccagaggaa aaagaaaatc ctcagttccg cttcctgcac 420
gtctctacag atgaggtgta tggcacactg ggccccaagg accaagcgtt tacggaaacc 480
accccttacg cccccaatag tccatactcg gcttccaagg cagcctcgga tcatctagtg 540
cgtgcctacc accacactta tggcttgccg gtattgacca ccaactgctc caataactat 600
gggccttacc atttccctga aaaattgatt ccactatgcc tgctcaatgc gcttgctggt 660
aaaccattgc ctatttacgg tgacggccag caaatccgcg actggctatt cgtcaaggat 720
cattgcagcg ccatccgccg cgtactggaa gcaggccagc tcggggaaac ctacaatgtg 780
ggcggttgga acgaaaaggc caatctcgat gtagtacaga ccttatgcag catcctggat 840
gaactcagcc ccaaggcaga tggctcaagc tacaaagacc aaatcacatt cgtcaaggac 900
cgtccaggcc atgaccggcg ctacgcaatc gatgcaagca aactggagcg cgagttgggc 960
tggaagcctg cggaaacctt cgagtcaggc atcagaaaaa ccgtggaatg gtatctgcaa 1020
aaccaggcat gggtgcacaa cgtcaccagt ggagaatacc gcaactgggt cagcaagcaa 1080
tatagcggga gcgcagcatg a 1101
<210> 112
<211> 1005
<212> DNA
<213> 鞭毛甲基菌
<400> 112
atgttattag taacaggcgg tacaggctac ataggttccc acgcatgtgt ggaactgatt 60
aatgcgggct atgaggtggt ggtgctggat aatttcagca atagccaggc gcatatcgtt 120
gaccgcatca agcagatcac gggcaaggca cccgtattgg tggaagggga tgtgcgggat 180
gaagcactac tgagtgattt attttctagg tacccattcc aggcagtcat gcattttgcc 240
gggctcaagg cggtggggga gtcggtcgcg cagcctttgc gttattacga taacaatgtg 300
gcgggtagtg ttaccttgct gcgcgtcatg caggcgcatg acgtcaaacg attagtcttc 360
agttcgtccg ctactgtgta tggcgatcca gccagtgtgc cgattcgcga ggatttcccg 420
ttgtctgcga ccaatcctta tggggcaagc aagctgatgg tggaggatat cctgcgcgac 480
ttggcagtct ccgatccaga gtggcgtatt gccatcctgc gttatttcaa tcctgtgggc 540
gcgcatgaga gcggcctcat tggtgagaac ccgaatggta tgcccaataa cctcatgcca 600
tacatcaccc aggtagccca ggggcagcgt gaatctcttt ctgtgtttgg cagtgactat 660
ccaaccgtgg atggtacggg cgtgcgcgac tacatccatg tggtcgacct ggtggttggc 720
catttgcgtg ccctggagcg gctggataag gaagctggtg tgttcacatg caatcttggc 780
acgggccaag gatatagcgt gctggaaatg gtcaaggcat ttgaagacgc cagtggccag 840
gctgttccct atcagctggt ggcacgccgg ccgggtgatg tggcggccag ttataccgat 900
cctgcttatg ccgagcaggc attgggttgg aaagcgacgc gtggcatcga gcagatgtgc 960
aaggatagtt ggcattggca gcaaaacctt gcccagagag gctga 1005
<210> 113
<211> 1419
<212> DNA
<213> 鞭毛甲基菌
<400> 113
atgctgcttc ctgtcattat gtctggcggg gccggttcca gattatggcc ggtttctcgt 60
gaaactctaa ctaagccatt tatcgaatta cctgatggca gaacccttct gcagaagact 120
ttgcaacgta ctgcttgcct ggatggtgtg agcgaagtgc tcacagtaac gaataaggaa 180
tattacttcc tgacacgtga tgtctatgag gcaacagaca ctaatgtttc ccatagctac 240
ttactagaga cgatagggcg caatactgct cctgccattg cagttgctgc actacatgcc 300
gctgcgaaac atggggaaga tgtagtgctg ttggtgatgc cggcagatca tcttattggt 360
aatcaaaaag ttttttcaaa agcagtgact gttgcgacag atatggcggt gaatggctgg 420
atagtcacgt ttggtgtaga gccaagcacg cctgaaacag gttatggcta cattgaaggc 480
ggagagtcaa ttggggactc aggcgcgcgt agagtcgttc gatttgtcga aaagccagat 540
ttggaaactg ctgagaaata tattgcttta ggtcgattta catggaatgc aggtatattc 600
tgttttactg caaaaaccat tattgctgca cttgcggagt atgttccaga agtgcttgag 660
atagcaaaaa agaccctggc atctagtgac tccaaaactg agcctgttgt attgggcgag 720
gagcactttg catcaagtcc agatatttcc atagattatg ccgtcatgga gcgtgcttca 780
aaagtggcgg tagtcgcagc tgattttgac tggagcgaca ttggttcatg gagcgccatg 840
gctgagttgg tccagtcaga tgagcgtggg aatagggtga atggcgaagc tttattggtg 900
gatgctaata attgctatat ccaaagtgat tcccgtcttg tggctggtat aggtattgat 960
aacctgctgg tggtcgatac acccgatgcc ctgcttgtgg ctcatcactc cagagctcag 1020
gatgtcaaaa ccgttgtgaa gcaactcaag cttgagtccc atagtgcggc aaattaccat 1080
cgcaaggtac accgtccatg gggcacatac accgtattgg aagaaggcgc taattttaag 1140
atcaaatgca tcaaggtaaa gcctggtgcc agcctgagct tgcaaatgca ccatcatcgt 1200
agtgagcatt gggttgtagt aagcggtata gctaaagttg tcaacggcga gcgcgagctg 1260
ctcattaatg ccaatgagtc tacttacatt ccagcaggac acaaacaccg tcttgaaaat 1320
ccaggtttgc ttgacctggt gattattgaa gttcaatccg gggaatattt gggcgaagac 1380
gatattgttc gttttcaaga tatctacgga cgcacttga 1419
<210> 114
<211> 795
<212> DNA
<213> 鞭毛甲基菌
<400> 114
atgatcagca tgttaaaagc cttatggctt tatcgcggct ttgtgttggg cagcgtcaag 60
cgcgagtttc aatccaagta ccgtaattcg ctgctaggcg cagtctggac ggtcttgaac 120
cccctcgcaa tgatcgtagt gtacacagtg attttctcgc aggtaatgaa ggctcgtttg 180
cctggcgtgg acagtacttt tgcgtttagc attcatttat gcgctggcat actcacctgg 240
ggcttgtttg ctgagattgt cgggcgctca cagaccacgt tcatcgataa tgccaacttg 300
ctcaagaaac tgagtttccc ccgtctatgt ctgccagtca tcgtcaccgc caccgcgcta 360
gttaactttg ccattgtttt tgggttgttc acagcgttct tgctgctgat cggtatgttt 420
tcgggttggc cttatttggt gctgatcccg gtattgatac tgatgatcgt ctttgctcta 480
ggcttgggta ttatattggg cgttctcaat gtgtttttcc gcgatgtagg tcagttcttt 540
ggcattgtgc ttagtttctg gttttggctt acgccgattg tctatccggt cagcattctt 600
ccagaacggg tacaagatta tatgcggctt aaccccatgg cgcgcttgat ggaggctttc 660
caaggaatat tggtacaagc aaaatggccg gactggtaca gtctatggcc agtgtttgcg 720
ctgtctatcg tgttgtgcct gctggggctg tctttattcc gcaaacatgc gggcgatatg 780
gtggatgaac tttaa 795
<210> 115
<211> 537
<212> DNA
<213> 鞭毛甲基菌
<400> 115
gtggattctg caaggagtaa gttttcatat ccagccagga gagacggagg cagctttgcc 60
gtgactgctg ccaagcgttc taatacgagt attaagccta accttgcagt gatcaattgg 120
atgcttgagc aagaagaccg gatgggatta tctaccccaa ggccttatcg tgaatttgag 180
gagcgtgtat atcgtcatcg cgatgatctc aggcgcttaa ttcattcgtt agtagctgac 240
ggcaaaaaaa tatatgggta tggagcttct gccaaaggta atgtagtact acaattttgt 300
ggctttactt ctgaggaaat ccctgccatt gcagaagtaa acgaagaaaa attcggacga 360
gtcactccgg gaacgcatat tcccattatt tcggaaaaag aggcgcgcgc tgccaagccc 420
gactacttct tggtgcttcc atggcatttc aaagatggta tcctgcgccg tgaaaaggac 480
tttctagctg atggcggcag gtttatcttc ccatttcctg agatcgaaat cgtctag 537
<210> 116
<211> 1041
<212> DNA
<213> 鞭毛甲基菌
<400> 116
atgaccataa aaactgccat cattaccggc atcacaggcc aagatggtgc atatctcgca 60
gaacttctcc ttagtaaagg ctataaggtt tacggtacct tccgccgtac aagctcggtc 120
aacttctggc gtattgaaga gctgggaatt gaaaatgacc caaatcttct tttggttgaa 180
tacgacctga ccgatttgtc agcaagcatc cgtctattgc agagcacagg tgcaacagaa 240
gtgtacaact tagctgcgca aagttttgtg ggcgtgtctt ttgagcaacc tattactacc 300
gcggagatca caggtgtcgg tgcgctcaat cttttggagg ccattcgttt agtaaatccc 360
aatattcgct attaccaagc atccacatcc gaaatgttcg gcaaggtgca ggcgattcca 420
caaacggaag atacgccttt ctatccacgc agtccttatg gtgtcgccaa gctgtatgcg 480
cactggatga ctgttaacta tcgtgaaagc tatggaatct tcggatctag cggtatttta 540
ttcaatcatg agagtccgtt gcgtggtcgc gagttcgtga cgcgcaagat cacggattcg 600
gtggccaaga tcaagctggg gaaacttgat tgcctggagt tgggtaactt ggatgcaaag 660
cgtgattggg gctatgccaa ggattatgtg gaaggcatgt ggcgcatcct gcaggcggat 720
gagccggata cctttgtact ggcgaccaat cgtaccgaga ctgtgcgcga ttttgtaagc 780
atggcgttca agggggctgg cattgctgtt gagttcaagg gcaagggcga ggacgaagtt 840
gccgtggata ctgcaaccgg taagatagtg gttcgggtca atccgaagtt ttaccgtcca 900
gcggaagtgg acctactgat cggtagccca gccaaggcca aggccaagct gggttgggaa 960
ccgaagacaa cgctggagca actctgccag atgatggtcg aggccgatct gcgccgcaac 1020
acggaaggtt tctcattttg a 1041
<210> 117
<211> 867
<212> DNA
<213> 鞭毛甲基菌
<400> 117
ttgagaattc tgcttactgg tgctgatgga ttcaccgggc gccattttct gacggccgcg 60
aaagcggccg gccatgaggt tgttgcactg agggccgatt tgacggacaa ggctgtattg 120
caacgcgaag ttgaggcggc tcgtccggaa gcagtggttc atctggcagc gatcagtttt 180
gttggtcatg cggatgttag tgccttttat gacgtcaatg tgatcggtac cctgaacctg 240
ttggatgcgc tggctggctt gtccgtgacg ccgcgcagcg tactgctggc aagcagtgcg 300
aatgtgtatg gcaatgcagc gcattcacct atcaccgaag agcaggcgcc ggcgccggtc 360
aatcactatg caatgagcaa gctggccatg gagcacatgg cccgtaccta tctggacaga 420
ctgccgttgt tttttgtgcg gccgttcaat tacacggggc cggggcaggc tgagtctttc 480
gtgattccca agctggtggc gcatttcgcg tgcaaggcgc agaccgtgga actgggcaat 540
ctggatgtgg agcgcgagtt caatgatgtg gctttcgttt gcgaggccta tctgcgtttg 600
ttggacaagg ctgtgccggg tgaggtgttt aatatctgca gcggtgctcc ggtgacattg 660
cgtgcagtaa tcgggatgtt gagggaattg acggcgcatg atatcgaggt caaggtaaat 720
ccgcagttcg tgcggaataa cgagatcaag acattatgcg gtgatccatc aaagctgttc 780
cgtactattg gagaggggag gctggttcct ttagcgctta ccttgaagat catgctggaa 840
cacgctacgc gaaaagaaaa aaaatga 867
<210> 118
<211> 1143
<212> DNA
<213> 鞭毛甲基菌
<400> 118
atgatgaagg taggttttgg tgtcaccgtg cttacacgtt gcctggcatt ggggggaatc 60
gatggaattg gtagttatac ccgggagctg atgaaaagac tcgaggctga cccggccgtc 120
gagcttttcc ctatctcgta cgggtattct ccgtcacagt ttcctatcgg ctcacgtgct 180
ccgacgacat ttggacgata tgcgccgctt gctgcagtat cggctgtatc cgggtttccc 240
tttctgggaa cagctcaatt gaaggagcgt gttgatctga ttcatgcgcc tgatcatctt 300
attcccaact acggaaaagt tcctgttatt gcatccatca tggacgcgat tcccttgtcg 360
catccggagt gggtatcccc caagttgcgc aagatgaaaa atgcgttatg gaagcgctct 420
gcgcactggg catcgcatat cattactatc tctgagtatt cgaagcagga aatttcacag 480
catttcggta ttgaggcaca aaagatcagt gccatcccgc ttggcgtgga tgagcggtgg 540
tttcagccgt tggaagaaga ggcgatgaag gtggtattga gacggtacaa tctgcctcaa 600
tactattttc ttgtcgtggg gacgctgcag ccaaggaaga atgtcggccg ggtaatcgag 660
gcatatcggt ccttgcccca agggatacgt aacgaagtgc cgttggtgat tgttggtagg 720
gcagggtggc gatgcgagga tgtggttgaa atgttgactt cgtcttcttc aggaaattct 780
ctgaggtggc tcaagcattt gccggatgcc gacttgcttg cagtgttgaa aggtgcaacg 840
gctttggtct ttccttcgtt gtatgaggga tttggtttgc ccgtagtcga agcttttgcg 900
gctggaactc ccgttattac ttccaatacc acttctcttc cagaggtggc gggcgatgcc 960
gccatgctgg tgaatcctct gaatgtcagc gacattgccg ctgcaatgca atcgatgctg 1020
gaacagccgg aactggcaga gagtttcagg aacaaggggc aagaacgcgc attggcatat 1080
tcgtgggaca aaacagcctc catgacgctt gacgtctata aaaagacgcg agaggctgct 1140
taa 1143
<210> 119
<211> 1200
<212> DNA
<213> 鞭毛甲基菌
<400> 119
atgatcatcc gttttctggg cgcacagtgg ctcgccgttg gttttgtcgg ggtcatctct 60
ctggcggtca gcattttgat tgcgcggacg cttgggccgg attcatttgg tgtttattcg 120
gttgtcttgt ccggcggagc cattgccgcc attctgcttg atggtggttt cgggcgattg 180
ttgcaaagag aacgcgccca tcccacacct gcattgctca gattcctgcc catattgccg 240
caggctgcct tggggcatgt gattatcgcg gccagcatat tttcgttgat cgctttattg 300
gtactgccca agcatgcgct gacgattgtt gcggttatct ggtttttcgc agcatctgtg 360
accaatcagt tcggtttgaa cattctccgc ggagatgggc ggatggtaag ggatgcctcg 420
tggcagatgg gcaatcgaac cttcacagct gcgtgcgtgt gcattgtcat tctgatggga 480
gctgagaaac cgtggcaggt attctttgcc cagtttgtcg gtgcgaccgc cttcggtttg 540
ctgatcatgc actatctgcg cacgcgcccg ctatggaaga ttcctcctac tctttatgcg 600
gcaaccttgc cattcgtgtg gttggatctc gcgacagtcc tttattttcg agcggacatg 660
ctgttgctgg aatggttaga tgtgtccaag tttgaagtcg ggaaatacgg ggttgcctgc 720
cgcttgattg aggcggtgat tctgcttgct tcgccgctct gtattatttt gttccgcaag 780
tttcgtctgg gtagcgcttc tccccgactg atgttgcgga gaatgctgcc ggtgctggca 840
ggggcgctga tggttggagt gttcttcatg gtgtttttct ggttgtgcag cacgcctttg 900
atcgcggttg catatggcga ggcctatgcg ggagctgatc atattctggc gatactcggc 960
tgcgctttgc tttttatttt gccaaatggc gtgctgaacc aagctgcgct agcgctgggt 1020
atcgaacgtt ggctggcaat gtcggcatct tttgccgcag tgctaaatat tgcaggaaat 1080
ctctggctga ttccccaata tgggttgatt ggagctgcct ggatgactgt tgtgaccgaa 1140
gcggtgttag gctgctgcgt tgcgttaggg ctatggcgcc accgtaatag gagtgtttaa 1200
<210> 120
<211> 1134
<212> DNA
<213> 鞭毛甲基菌
<400> 120
atgcaggatc ttgccgttgc tcatgtttat cgtacctatt ttcctgaccc tccaggcggg 60
ttgcaggagg caattcgcca gattgccctc acgacgggta tgcagggcgt cgataatacg 120
gtgtttacgc tttctccgca gccgcgtccg gcaatcttgc agcgtccgga ggcttgtgtt 180
gttcgttgcc gctcctgggc ggctccggca tcatgcgatc tgggcggtat cggcgcattt 240
cttgcgtttt ccaggttggc ggaaaaatct gatgtgctac attacctttt tccgtggcca 300
tttgcggatg ttctgcatac ggtggttcgc ccaggttgtc cggccgtcat gacttatatc 360
tcggacgtgg tgcgtcagca gcttttaggg aggttatatg ctcctttgat gtggaaggtg 420
ttgcgccaga tgaggcttgt ggtggcgaat tctccagcgt atgcacgcac cagtcccgtt 480
ctctcccatc ctgagattcg cgaaaaagtc agggttattc cacttggtat tgaggagtct 540
tcttatccta aatcagggga tgaggagatt ctgcagcgtc taggcattgg gaaggatgag 600
ccttattttc tttttattgg cgttcttcgt tattacaaag gcgcgcattt tctggtcaag 660
gcagcaaagc ggataggcgc aaaggtggtg tttgctggcg cggggccgga aggcgcgcgc 720
ctgaaagcat tggctggcga agtcggtgca gagaatgtga tttttgccgg gatggtgact 780
aacgcggaaa aagtaacctt gcttcaatgc tgcagagcgc ttgtgttgcc atcgcatttg 840
cggtctgaag cgtacggcat ggtgctggta gaggctgcca tgttcgggaa gccgctgatt 900
tcttgcgaaa ttggcacagg cacttcatat gtcaaccatc atgaagaaac agggtttgtc 960
gttgagccgg cctctcctga agcattggcg tcggcgatgg cggttttgtt atcagaggat 1020
aggctggcta cagagatggg agctgctgct cgtcagcggt atgagctgct cttttccggc 1080
ccggcattag gaaaggcata tgctgcattg ttccgcgaag ttgacgcttc gtag 1134
<210> 121
<211> 942
<212> DNA
<213> 鞭毛甲基菌
<400> 121
atgatgcaat tactggtgac aggcgctaca gggtttgtag gtaaaacttt gtgcagtgcg 60
ctaaggcggc agagcttccc cgtaaaagca attgggcgtg cgggcactat ccgggctgac 120
gctttgggtg atcaggttgc ttcaattgac ggtcaaacgg attggtcact gatattggac 180
ggcatcaatg ccgtcatcca tctggcagcc agggtgcacg tcatgcggga acagcttgct 240
gatcccttgg cggcatatcg tgaaacgaat gtcgaaggga cgctgaatct ggcgcgtcag 300
gcggcaaagg ccggagttaa gcggtttgta ttcattagtt ccatcaaggt caacggcgaa 360
cagactctac ctggaaagcc ttttactgcg tacgatgtac cagctcccga agatgcgtac 420
ggtatttcaa agttcgaggc agagcagggt ttgctggccc tggcgcggga gacagggatg 480
gatgtggtgg ttattcgccc tcctttggtt tacgggcctg gagtgaaggg taattttgcc 540
agtatgatga agttggtgaa aagtggaata ccgttgcctc tgggcgccat tcataaccaa 600
cggtctttgg tggcgattga taatttggtg aacctcatcg tcacgtgtat tgaccatccc 660
gcggcagcca accaggtttt tttggtaagc gatggcgagg atttgtccac ttcagatttg 720
ttgcggcgtt tggccaaggc tgcgggcgtt tcctcccgat tgatgccagt gtctgcccgc 780
tggctagaga tgggtttgcg tatgtgtggc aagcgattga tcgcccagcg tctcctggga 840
tcattgcaag tcgatatttc caagacgcgc gagttgttgg ggtgggttcc gccgatctca 900
gtggatgagg gcttgaagcg ctgtttctct accaagggct ga 942
<210> 122
<211> 552
<212> DNA
<213> 鞭毛甲基菌
<400> 122
ttgatccgat tttttgacat tattttttcg gtgataggct tggtactggg attcccgcta 60
ttgctatcga tttataccct cggcttgttt gatacaggtg ctcccttgtt tcgccaggtg 120
agggttgggc gctaccggca gccgtttact ttggtgaaat ttcggacgat gaaggtggat 180
acggcttctg tggcgagcca tctggcttcc accaattcca tcacccggct cggacggttc 240
ttgcgcagga ccaagctgga tgagctgccc cagctctgga atgtcctgaa gggagaaatg 300
agcctggtgg ggcctcgacc gaacctgttc aatcaggagg agctgatggc cgagcgcgag 360
ttgcgtggcg tttaccatgc gcggccaggg attaccggcc ttgcacaggt gaatgatata 420
gacatgtcga cgccaaggct gcttgccgag accgatgcca ggatgctgcg cgagatgaat 480
gtacggcttt atttcaagtt gctgattcag acggtgctgg gtcgaggaca gggcgaccgg 540
gtcgtgcgct ga 552
<210> 123
<211> 1914
<212> DNA
<213> 鞭毛甲基菌
<400> 123
gtgctgcatt atttcccctc attcaagtgg tcgaactaca tcagtttgaa gaatccacgc 60
tctttgagcg cttggatata tgacattgtt gctgctgcgc tggcatggtg ggcagccttc 120
ctgttacggt tcaattttga tattccggcc aattttgtcc agagtatgct cgacagcgca 180
gcatgggtga ttccgctgca ggcatttgtg tttctgctgg ctgggttgta caaaggcgtc 240
tggcgttttg ccagcctgcc ggatttgcag cgcttggtgc gcgcgattgc gatcagcgca 300
gtgcttgtgg ttgcgatctt gttcatgttc aagccacacg gcattgttcc tcgctcggtg 360
ctgatcttgg atcctatgct gttgctgctg ttgatgggcg gcagccgctt tgcttaccga 420
gcatggaaag aacatcgcct gtatggttct gcccagtttt ccggaaagcc ggtgctggtg 480
ctcggcgcgg gtgaggcagc gattgccttg ttgaaggatc tttccaaaag ccgtgaatgg 540
catgtcgttg ggttgctgga cgataagaaa accatgcatg gccgagagct actgggcgtc 600
aatgtgctgg ggtcgattgc gcaattgcca cagatcgctg cggatttgtc ggtcaatcat 660
gtgattgtgg ccatgccatc cgcgcgtcat caacgacgca gggaaatcgt cgagctggca 720
agcagaaatg ggctgactgc gctcacggtg ccgtcgtttg atgacctgat gagtggccac 780
ctgagcatgg cacagattcg gccggtcgag gtggaggact tgctggggcg ggagccggtc 840
agtctcgatg gagaggggct ccagcatttg atcgaggggc aggtgttgct gattactggt 900
gcaggtggtt ccatcggttc tgagttatgc cgccaggtgc tgaaataccg tccagcttgc 960
ctggtctgcc tggatcagtc ggagtacgcg ttgtatcggt tggagcagga gtttgacaat 1020
ctggagtttg atacccgcat tgaatacgtg gttggcgatg tcaggaacgc acgccgggtg 1080
gggcaggtgc ttggccgtta tatgcccaaa ctggtgttcc atgctgctgc gtataagcat 1140
gtgcctttga tggagaaccg caatgtggcg gaatcattgt caaataatgt cagcggtact 1200
tacacgctcg cccaggcatg caaaactgca ggggttgcca agttcgtgct gatttccacc 1260
gataaggcgg ttaatcccac caatgtgatg ggggccagca agcgcctggc ggaaatgata 1320
tgccaaggcc tgcaggagga gtcgggtacg cgttttatcg tggtgcgctt tggcaatgtg 1380
ctgggcagta gtggcagtgt aatccccaag ttccgtgagc agattgcggc gggcgggcca 1440
attaccgtta cccatcccga gatcactcgc tatttcatgt ccatcccgga ggcgtgccag 1500
ctggtcatgc aggctggatt gatgggtggt ggcggggaga tatttgtgct ggatatggga 1560
gaccctgtgc ggattgtgga cttggcccgt gatatgatcc ggttatccgg gcttaatgaa 1620
gatgacattc agattgtata ctctggcttg cggcccggcg aaaagctgta cgaggaactt 1680
ttggctgacg acgagctcac tgtaccaaca ccccacgaca agctacgtat tgccgtggcg 1740
cgaagcgtgg atggtgcttg ggttcaggca ttgctgaaat ggatcgacag ggcatcgctc 1800
atagatgaat ctgtcatcaa gcaagagctg ggcatgtggg tggaggagta tgcaggggat 1860
attcatgcca atccatccat gatgttcccc cccgagtctt caaccataca ttag 1914
<210> 124
<211> 876
<212> DNA
<213> 鞭毛甲基菌
<400> 124
atggcaaaaa aaattaccaa ggcagtattt ccagtggcag gtttagggac acgtttcctg 60
ccagcaacca aggcgagtcc caaggaaatg ttgccaattg tggataagcc tctgattcag 120
tatgcagcag aggaggctgt ggccgccggt gctaccgagc tgatttttat tatcgggcgc 180
aacaagcgca ccatcccgga tcattttgat aagtccttcg agctggaagc gacgcttgag 240
gcaagcaaga aaaccaaggt gctggaagaa atccgcaata tcctgccaaa aaatgtttcc 300
tgcatctata ttcgccaggc cgaggcgctt ggtttggggc atgcggtatt gcttgccaag 360
tccgtggtcg gcagcgagcc tttctctgtg atcctggccg atgaccttat tgatgccgac 420
aaacctgcca tgcagcagat gacagagctg ttcgaccaag agggtgtcag cattctgggt 480
gtcgaggatg tggagcccag tgagacggca agctatggca ttgtggatgc gacagaggtg 540
agtggcccga atgtgttgca attgaatggc attgtggaaa aaccgcagcc ggaagaagcg 600
ccctccaatc tggctgttgt cggtcggtat attctcacgc ctgaaatttt tgaatgcctg 660
gagaacgtca agccgggcaa gggcggggaa atccagttga ctgatggcat tgccgccttg 720
atggaaaaac agaaaatcct ggcttaccgt ttcgatggga agcgctacga ttgcggcagc 780
aagctgggtt atgtcaaggc gaacgtcgag tattccttga agcatgagga gtttggcaaa 840
gagtttgccc agtacttacg tgatctaacc aagtag 876
<210> 125
<211> 819
<212> DNA
<213> 糖原甲基菌
<400> 125
ttgctacaac aattttctat cggggttaga gagcaccatc acaaggagct cactccagac 60
caggctggcg ctttcctgga ggtggttgac gcatcattgc gtatcaagaa aaaggcccag 120
ttcttttcct ggctacaagg ttattttcaa ttcctgctac cgcatgaagt actactctgt 180
ggtctgtcca taggcgcagg acgtcccttc acgctggaaa ccttcagcag cacgcgctat 240
gtcaccgata cccatacggc cgtgagcatg caggaaactg atggtgtggt gttgcgtgcg 300
attcagtcct ggcaggaaac cagcctgcct gtgttggttg atccttatct acgtcccggc 360
agtttcggta atttcacggt gccggagata gatcaggcca atctacaggc cagcgagcta 420
cgcaatctgg cagcttatgg tctgtcttct gccgatggca gcatttcctc tttcttctgt 480
ttttcacgcg tggccgggga gttgaatggc aaccatgcct atctgctgga attgctggtg 540
ccttatctgc actcggtgct gatgcgcgtt agcgacagtg ctacggcttc tgccgatatg 600
ttgggcgata gctcggtggc ggggctgatc accatgcgcg aaaaggaaat cctgcattgg 660
gtacacacgg gcaagagtaa ctgggaaatt gccaccatcc tgcagatcag ccctttgacg 720
gtaaaaaacc atatgcagaa tattttgcgc aagctggatg tgcaaaatcg cagtcatgcg 780
gcctccaagg ccttcaggct gggactgatt cgtaactaa 819
<210> 126
<211> 1140
<212> DNA
<213> 糖原甲基菌
<400> 126
gtgggttatt ccgaccctgt gctggctcgt gaaggtgatg tcatacggcc ctatgtcagt 60
gcaacatatg tttatgatga caacctgagg cgccgctctg acaaggagtc cgatacgagt 120
gtagtgggcc gggttggcat tattctggat aaggatatta gtcagcagaa tttctacgcc 180
aatatcggtg tgaatgaaac caaatacaac aaaaattcag agttagacaa tacaggtaaa 240
gatattgtcg ctcgatggaa ctgggcagtg ggctcgcaat tccggggcaa ggttgagtac 300
tataaaaacg aggctatgct gccttttgcg gattttcgtg gtgtggaatt gaatatgcgt 360
attcaggagc gtaaaacttt tgaagcaaac tggcgtttcc attccagttg gcgcgcgcgc 420
tttggtgtgc agcgccagga tgttgagtat gactctcaaa cattgaatgc ggcttctttt 480
caggaaaatt cccagcacgt aggtttggac tatttagctg agtcaggcag taaggttggc 540
ttggtcttca ctaatgggcg tggcacgcgg ccctttgata ggcctgcttt tttcccgggg 600
attggtaccg tgtttgtcaa taatgactac aggcagcaat cactcaaggc ggacatactt 660
tggctttatt ctgccaaaac acgatttgaa tttttggggg ggtatgttga tcgtaaacat 720
gacagcttct cacagcgcga tttttccgga tttaatgccc acgggaacat ggtgtggtcc 780
attaccgaca aaacctcttt caagacagcc gcatggcgcg atgcaaatgc tatatcaatc 840
gtaactgcca gctatgtgat tgatagtggc gcaagtgcaa gcatctccta tagcgcaacg 900
agtaagatcc tgctgtcaac ttcagccagg tatcaacaac taaaatttga aggcgatatc 960
accgggcaag atcaaggtcg taccgacaag aataaggttt tttcttttgg ggtaacgtac 1020
agccctcttg aatcgttaag tttcactact ggtctaaata gaagtttgcg tgactcaacc 1080
tcaccaattt taaactacaa ctcgacaagc atttcgctta ctggtcgtta tgaattctga 1140
<210> 127
<211> 1384
<212> DNA
<213> 糖原甲基菌
<400> 127
atgaccgtaa atgacatccc tttagtagcg tttttcaagc agctgctcga cccgctgatc 60
attcttggta cgctgtatgt gttcaccctg ttgtttggtg agccttttaa tggctactac 120
ctgattctgg cgttgctagc ctactttgtt tcctctaatg tctacgagcg tctggatctt 180
taccgtacct ggcgtagtgg caagatactt ggttatatcc gcgatattct ctttggctgg 240
ggtattgtca tcgctgtgct gatgttcatc ggctatgccg ctgatctatc cagtcagtat 300
ctggatgaga tgatatatgc ctggtttgcc agtgtgccga tgatatttat tgtcacgcat 360
ctggcgatac gcaaaattgc ctcggatttg cacaagaatg gtgaagtcag gtccgtagtg 420
attatcggtg ccaatgatat tggcgtgcgc ttgatcaatc gcatcacgga cgacccgtac 480
ctgtttatgg aggtcaaggg gatctttgac gacagagagg tcgccaggca ccccaagggc 540
atgcgtaatc tgcctttgct tggttccatg tcggaaattg cgccatatgt ccgcgccaat 600
aatacccaga ttattttcat cagcctgccc atgtcggcgc agccacgcat caggcagtta 660
tttgaagaat tgcaagacac cacagcatct atttactttg tgccggatat ctatattttt 720
gatctggtac aagcgcgctt tgatgatgtg gctggtgtgc ctgtggtcgc tattcttgag 780
acgccattca ccggtttcaa cagtttaatc aaacggacta gtgacattat tttggcgtcg 840
cttattctat taatgctgtc tcccatcatg ctgacactgg ctctggccgt gaagttgacc 900
tccccaggcc cggtgatttt caagcagcga cgttatgctg aatggtgagg aaatcattgt 960
ctataaattc cgctccatga aagtaatgga agatggtgac aaggtagtac aggcgcagaa 1020
gcgagatcag cgattgacac cgattggtgg tttcttgcgc aagaactcac tggatgagct 1080
gccgcagttc atcaatgtgt tgcaaggtca gatgagtatc gtggggccta gaccgcatgc 1140
cgtttctcat aatgagcaat atcgcaagct gattcgtggc tatatgctgc ggcacaaggt 1200
caagcctgga ataacaggct gggcgcaggt gaatggttta cgtggtgaaa ctgatacctt 1260
ggacaagatg gagtcccgta tcgagtatga cttggattat ttgcgccatt ggtccctggc 1320
ttttgacttc tggattatcg tcaggacggt gctggttgtg ttcaaaaaag ataacgccta 1380
ctag 1384
<210> 128
<211> 933
<212> DNA
<213> 糖原甲基菌
<400> 128
gtgaataacg gatttgtaac taacttcaag caatccagaa ccctgtgtgt cggtgctgtg 60
attgtgctcg ctttcgcatt gtcgggctgt ggcgacaagc atgaatccaa agccagccag 120
tctctggtta aggtcaatgg caaggaaatc accgtacatc agctgaatca ggagctgggt 180
cgtgccaaca ttcaggagaa tcagcgcgag caggcaacgc agcagattct gactgcattg 240
atagatcgcc agttacttga agaagctgcg ctcaaggcca aggtggatag ggatccaaat 300
gtgatgacca cgattgaacg tgcgaaatca caaatcattg ctcaggcata tctgcaatcc 360
aagttaggca gtgtcgccaa gccaagcaaa acagaaattg agaattttta taacgagaat 420
cctcaattct tcagcaagcg cagaatggtg gaaatggatc aattgttgat tgatactaaa 480
ttcgccaatg atgaattgaa aacagcactt ggcaaactca agaccttgca ggaagtagcc 540
gcatggatgg atgcccataa tattcagtac gatcaaggtc aggtttcacg cagtgttgct 600
gaattgccgc cacagatttc cgagcgcctc aaggccgagg ataagggtaa gttgttcgtg 660
atcggcatgg gccctcgcac catgttgatc atgatgaacg agatcaagga cagcccagtt 720
tcacttgcag aagcaacacc gcaaattgaa aacaatttgc tgaataaggc gcgcaaggaa 780
gttgctgaaa atgaagtcaa gcgcttgaaa gccgatgcca agattgagta catcgataaa 840
aagatggaaa cagcgactga aaccaaggca gccaaaaaga agccaagctc tactgaggat 900
gatatcgcca gtggtgttag tggcttgaaa taa 933
<210> 129
<211> 795
<212> DNA
<213> 糖原甲基菌
<400> 129
atgaaaaaat taatgacatg gtttttcttg ctgatgctga gtctgacgcc ttttgtaacg 60
catgctgcag aaggtgacat tcttctcggc gctggcgatg tgctgaaaat atcggtgttc 120
gagcagcctg atctgtcact tgaggtcaga gtgagtgaat caggttccat tacttatccc 180
ctgataggtg aagtgcgtgt gggtggtggt acggttgccg ccgccgagca aagaattgcc 240
accatgctgg aaaagggtgg tttccttaag agtgctcacg tcaacatcat cgttgcgcaa 300
ttgcagagcc ttcaagtctc tattctgggt caagtcaatc gcccgggcag ataccctata 360
gatagcgcta aaacgctggc ggatgtgctt gccttggctg gtggtgtatc acctgaaggt 420
ggcgatctga tcacgctggt gcataacgtc gatggtaaag cggtcaggga tcagattgac 480
cttgctgaca tgatgcgtac tggcgatctc agcaagaaca tccgcgtagc tggtggtgac 540
atcatttatg ttgaacgttt cgataaattc tatatctatg gtcaggttca acgtgccagc 600
cattaccgtc tcgaacatga aatgacagta ttgcaagcgc tttctgtagg tggtggctta 660
agccctcgcg gcacagaaaa aggcgtcaag atcaagcgtc gtgatgctag cggccatatt 720
gaagtaatca ctgccaaaca tgatgacctc atcaagccca acgatgtgat ctatgtgcag 780
gaaagtttct tttaa 795
<210> 130
<211> 1389
<212> DNA
<213> 糖原甲基菌
<400> 130
atgagctttt ctcaactttt actgatattc aaagcgcgat ataagatatt gttaagcacc 60
attgttgtgg ccctggtcgt agcaattgcg ctcaatattt tcttgccaaa cagctataag 120
gcaaccacca gtatcctagt caactataaa ggtgtagatc ctgtgactgg tatggctgtc 180
cctgcccagc tgcttccagg ttatatgggt acccaggtgg atatcataac tagcaagaaa 240
attgctaaga gggttgtgac cacattaaag ctcaatgaaa gtagtgaggt tgtggagagt 300
ttcaatgact ccacaggtgg tgaaggtgat atcgttgatt ggttggcgga tttgctgatc 360
tcacgtatcg aagttcaacc tgcgcgcaac agtagtgtgt tgcagctgga gtttgatgga 420
gccaacccca aatttgctgc tgttgttgct aactcctttg ccgaggaata tatcaaggcc 480
actatcgaac tcaaggttga gccttcgaaa aaggcggctg aattttatac cgggcaattg 540
aaggatttgc gtgccgatat tacccgggcg cagcaaaagc tttccgatta ccaacaagat 600
aaaagcatcg tcagcgttga tgagcgtcta gacattgaac gtgccaagct gaatgaactt 660
tcctcgcagt tagtgatgtc acaagggcaa actcttgagg cacagtctcg tcagactggt 720
gcacaaggta gcaatgctta tggatctccg gatgtcgcga gtaatccaat ggttctgcac 780
ctgaaaacag agattgctag gtctgaatca cgcttcgcgg atatctcaca aaaatatgag 840
agaaatcacc cactctatca gggggccaaa gctgagcttg acaatctgaa gtctgaatta 900
agtaagcaaa tccaggcggc taccgtcaat atatcgagca attatagaat ccttaagcaa 960
cgcgagagtg aaatccgcaa tgccttggct gagcaaaaaa ccaaggtcat gctgttgaac 1020
aaggataggg atgcactgac ggtattgacg cgtgaagtcg agggtgcgca acgcgcttac 1080
gaactcgcga ctcagcgata tactcaaata aatcttgagg gacagtctaa tcaagctgat 1140
gtatccatcc ttaatccagc gacaccacca cttaagccat caagcccgaa aaaaatattg 1200
aacgtggcag ttgcgttggt gctgggtaca atttttggct tgttgtttag tttgttggct 1260
gagctcacta atgagcgaat tcgctcagaa agagtgctgg tagagattgt tggcgcaccg 1320
ctgctgggtg tgatcgacaa aaataaaacc cattccagaa ttcagcgcct gctggctaaa 1380
aaaccctaa 1389
<210> 131
<211> 879
<212> DNA
<213> 糖原甲基菌
<400> 131
atgactaatg atgtttccaa tactagttcc attccggcat tgaatgctga tttcaatatc 60
ggtggaatgt tgctcaagat gggtaagatt acaccgcagg atgcggagcg tatcctgcgt 120
gtgcagaagg aaagaggcgt tcgctttggt gaggctgccg agagtttggg cctagtttcc 180
tctgccgata tcaactatgt attatccaag cagtttgcct atccctacct gatggatggt 240
cgcggcgatt tctccgagaa cttggtcgcg gcttatgatc cattcagtat caatgtggag 300
aagtatcgcg ccattcgtag ccagctcatg ctctactggt ttgcacaagg gaaaaagagc 360
ctgtcatttt ccagtgttta cgacaaggac gacaccagtg acttggttgc caatcttggc 420
gtggttttct ctcaactggg agagaaaaca ctcatcattg atgcccatct tgatagccca 480
cggcagaatc gcatttttaa tatcaagagc actgcgggtt tgtcggatat tctggcaggc 540
cgggttacgg attactcctc ttccatcact aggctagtcg agttcgagca tctctccatc 600
ttgtcttctg gcaccattcc acctaatccg cgagagcttc tgggacgtgg tttcctcaag 660
cagttcatca cggcaattgc taatgactac gatgttatcc tggtcgatgc accttccttt 720
gtccgccact ctgaaccgtt gtctgtggca agtgctacgg aaggggtggt gcttcttgcc 780
aagcgtcatg tctccaaagc caatgacttg agcaaagtgg ttgatcagct ttccaagatc 840
agggtgcctg ttgttggcac ggtattgact gaaaactaa 879
<210> 132
<211> 900
<212> DNA
<213> 糖原甲基菌
<400> 132
atgagcttga accagagcat tgcggtcgcc agtacccagc taagaaggta ccagcatgtg 60
ataccactgc tggtaggctt gctgttctta tttgtgccca cctacctgaa cctgacgaac 120
acggtctggc agatgcagga tcaggcgcat ggccccttga tcctgatggt ggtgctgtac 180
ctagtctggg tggacaagga aatactgcta gacacggcaa acttgagaca aagcgggcgt 240
ggtgtgggcc tgttgctgtt tttgtttggc ctgttggtat acatcatcgg gcgttcacaa 300
gatttgctgg tgtttgatgt gggctcgcag attccggtat tggctggctt gctgttgatt 360
ttctataagg ccaaaaccct caagcgcttc tggttcccct tgttcttctt gttcttcatg 420
attccattgc caggctccat gctggatgtt gtgaccttgc cgatgaaggt cgctgtctct 480
tacgtggccg agcatgtgct gtattggttt gattacccca tcgcgcgttc gggtgtgatc 540
attcagattg gtcagtatca gttgctggtg gcggatgctt gtgcaggcat gcataccttg 600
atttcactgg aggccctggg cctgctctac ctcaatatcg tcaggcatga ttccctggcc 660
cgtaacttgt tgctggcctt gctgattatc cctatttcct tctcagcgaa tgtcatacgc 720
gtgattgtgt tgaccttgat cacctactat ttcggggatg aagtgggcca gggctttgta 780
catggattcg cgggtatttt gttatttgtc gtggcattaa ccctgattat ttcagtggat 840
agcctgatcc aatactttgt tggcaaacat acacagcgta aggctagatt gcagagttga 900
<210> 133
<211> 687
<212> DNA
<213> 糖原甲基菌
<400> 133
atgagcgtca gattaatcaa tatcctggca gtatgcatgg tggtgagttc tggcctggcg 60
ttggctttga cccctgatct tagctccgtg cgggatgatc cacatcttga aagtttcgtg 120
cctagcagct ttggtcagtg gcaggaagtc aaaaccaatc aggtgcagat ggacctgaca 180
gtcaggagag atggcgaacc cagcatcgat aacccttatg atgaagttct catgaggagt 240
tatgccaatg aaaagggtca ggtcattatg ctggctcttg cctatggcaa attgcagcgg 300
caggaagtca aggtgcatag gcctgaactg tgctatacgg cgcagggttt ctccatcaga 360
aatcagcagg ataccgcagt gaatgtgggg gcaggcgcaa cacccatccc atccaaggcg 420
ttggttgcgg cttcaagaca gcgcgaagag ctggtgcttt actggatcag gataggcgat 480
atgatcagta agagtgcttg ggagacccga ctttatattg tggagcaagg cctcaaacat 540
caactggtag atgggatact ggtcagaacc tcacagatat tgggtgaaga tgatgccgag 600
caatctttgc agctacaaca acagttcctg cacgatctgg tgcaagcagt gcccagggac 660
aagcgtaaat acttgattcc atcataa 687
<210> 134
<211> 1137
<212> DNA
<213> 糖原甲基菌
<400> 134
ttgaagatat tatttctaag tcacactgcc gcagggggcg aatttgtagt tggctcacat 60
caactatcta aacaattcgc cttgcaaggg catgaggttg tccacctcag tccgccagtg 120
acaccagcac atctgacact gttgcagaaa acaccgtttg agcgtgtccg gtttaagcgc 180
tggatgaaag cgggtgatgt catcaaccac gtgaccgaca ttattccttt ctcattaata 240
ccttggggta ttgccacccg cttgggatct ggtagcgata tctttggtta cttcctgaag 300
ttttcagcac tcagacaact ccgtaaacat caattttcta atcctgacgt agtgttgatt 360
gatgagcctc gattaggcta tctactcaaa tatttcccta agtcaaagat cgtataccgc 420
cccactgata tttatcatga aatcagaaat gatcccagta ttgtagatgc tgaaaaaggg 480
ttgatatccc aggtacacgg cttcattgcg acatcagagc ctgtaagaca gcatttgaat 540
cgcctaggtg ttgatgaggt gctattgctg cagaatggtg tagatctaga tcattacctg 600
aattttacaa aatccaaact ggatttgccg cctgagccaa gggcaattta tgctggagct 660
ctggatcatc gctttggttt tgatgtgctg aaaagtgcag ccacaaaaca ccagaaaatt 720
tcatttttat tggctgggcc agtagaggaa aaatacaagg cggcatttag tgatcttgcc 780
aacgtacact ttcttggtca tgtgcaatat aaagcgttgc ccaatctctt gagtcagtgc 840
caaattggtt tattgccgat gtctgatcat ccatccaacc ttggccgtag tcctatgaaa 900
ttgtttgaat atgcagcagt cggacttccc gttgtttcta cctcaacacc agagcttgag 960
cgcagatcat taccctttgt atttttggct gagaatgccc agattttcac agataaactt 1020
ggtgatgttt gcaatgcgga tatcaaaata ttggctcagc aggctcgaga taatgctaag 1080
catgagtctt gggcaagtaa aaccatcaca atactgaact atatttattc aaagtaa 1137
<210> 135
<211> 1263
<212> DNA
<213> 糖原甲基菌
<400> 135
atgaacaaaa ctactgaacc acaagatagt caaaccaatg ttccatggtg gctatcccct 60
catggactat gcttaggctt tcttttgcct atgatcttgt tgatctggtg gttggggtca 120
gtgagatcac caacattaac catacggggt tatatatatt taagttctga atatatagct 180
ctggctgtgc taattgttgt gctgtcagca agtgcagcct ggatgggaag cttcgtcaag 240
acaaaagtca gagtgccgcc agactctcag gttaatatgg ctttgcgggt attaggctat 300
gtagcagttg cagcatatat atactggttc aaagagctga ttatcaatcc tatgaatatt 360
attaatatat ttacagggac aggtttatca agacaggaaa ttggtgcaac gcaagggatt 420
acatcacttg ttaacttcac cccaatattt atttcgattt acatatatgc cagatatatc 480
gccaaattac ctttaagaca agatgttgta ttgttgttct atgcaattgt tttattgaca 540
ttgctgcggg tatttgcctg ggcagagcgt ctggcattaa ttgaaattat tttgccattt 600
gcgttattga taacgcggca acaagtgttc agtaagatta aaattttgca attcttcatt 660
aaggctggtc ccttcgcggg attgcccttg ctggtgcttt actttggtat ggcggaatac 720
ttccgctctt ggagctctac aacttacgcc gggaaatcga gtttttggga ttttgctcta 780
gggcggattg cttcatatta ttacacctcg ctcaataatg gtgcgggaat gctggctact 840
gttaactggc caacatatga attcgaaaat gtgttgaatt ggatgcataa atttccaatt 900
tttggcggcg tgtttcgtta ctacgtagat ttgcacacta tgagaatggg tgagtttctc 960
gctcagtatg gtgatgagga gttcaacaac ccttctggga tattttcagt gatcctggat 1020
ttgggcttgc catttggcat tatctacttc tttataaccg catttcttgc aggaatcttt 1080
tataaaggct atttgagagg caatttttta agtgtaattt tttatccgtt attttttatt 1140
acgttattgg aaattttcag atatccgtat ttaggaacgt cccgagcttt taccgagatt 1200
attggtgtga ttattgcttt ctttatagtt aagggaagga ctgaaaatga tagaaaatcg 1260
tag 1263
<210> 136
<211> 1365
<212> DNA
<213> 糖原甲基菌
<400> 136
atgatagaaa atcgtagaca cctggttaaa tcattattct tgatgctatt ttcatcctgg 60
cttcccaagg tcgcctcggc agcgcctaag gtggtcgggg gcaatgcaga cttcactaga 120
gctttagatg acgcgcttgc tggacgcacg gaagtgctaa gcggttatta tgaaataagt 180
aatcctttaa gattttcact gaagagtggc accgtaaaat ttgcaccaga ttttcagctg 240
aaattcttga atgataaatt aagtggttta gtattttcga gttgcagtga tttatcactc 300
attggtggag atttttcgta caaaaacccc ccagctagaa gaattggaca tggtggtatt 360
tacgagttct ctagatgtac caaagtcatc gttagagatg gattttatta tgacacacca 420
ggtacaggta tcatttttac cttatgtgat gattgtgcag taattaaagc tacggtttgg 480
aattcctggg ctgatgggtt gcactttgca aattgcaata actgcatcgc cttggattat 540
cagtctacca atacagggga tgatgggttg gcgtttgtaa actacaaaaa acatcccgat 600
gcagtaggtg gttatgcgaa caacattgtt atcaatggtt cttatgcacg aggaattgcg 660
attatcggtc aatctggtgt gactatagac aagtttgaaa ttaggcacac ttccgcagaa 720
ggattaaaga ttggaagtga gcaatactat gacactagaa ttccttccaa tgtgacaatc 780
aaaaacggca ttgttgaaga ggcaggtact tggtgcgtgg caaaggcaac tggcaatggt 840
ttcctagtcc aaggtgctac cgataaaatt gttgttgaga atttgactgt caatgcccca 900
cgcgtgcatg gaattgtttt cgacaggcat ggcggtaatg tcaaaatgaa agatatcgtc 960
gtcaagaata caaaagcaag tggcataacc atgatggcgg ataacatcga gttagtgaat 1020
ggggagtttt taaatattgg aacaacacct ctttacgtca ataaagcatt aactgctaat 1080
ttctccaaga ttaatgtcaa taccttcgga ttcgcagata aatcaagttg gcctattttc 1140
tgggctgttg aagctaagaa tgtgttaatt aaccaaatga aagtggagtc caccaccttg 1200
gttagaattg gtgggaaaaa cgttatttca catcagataa ctggggtgca gatcagtggt 1260
gtgcagctta gcggactgct ctctgatggg cttaattcca aaacaacatc ggcggtttct 1320
gctataacat caactgctgt taagtttatt gagcagtgga attag 1365
<210> 137
<211> 1107
<212> DNA
<213> 糖原甲基菌
<400> 137
gtggatgcag gtgcgagatt gaggatttca tggatcgatg tctgccgtgg atttgcaatg 60
ctgttggttg tggttgggca taatcagata ttaatgggcc aaagtctttc tttggtaaaa 120
tttatttatc tttttcatat gccactgttc ttttttatta gtggtataac cctcaagcca 180
gatcaaggat taacgtacta tttcacgcgg gcgattaatg ttattgcggt atattttgta 240
ttttcatttt tagttcttcc ttttgtttta atgaaaaatc cagatgatgg tgttttcaat 300
atagttcttg gtattttgta cggaactgga catacaatag aagttgctcc tctctggttt 360
ataccatgtt tatttttctc tattgttttg gtcggtctcg cattagttat ttcaaatcat 420
tttaataaca ctgatcgtga atcaaataga agtccgattt ttttccttgc attattgttt 480
atcggagttg gtgtttttct cattaactca attcattatt atttaattga taatcttgct 540
tggggtagtc tgaaaaattc aggaatgatt tggagtattg atatagcaat aattggtgct 600
ggctttattc ttctaggtat gtacgcaaag gtatttgttg ataagtacaa aattactgaa 660
atcaaatcaa tatatcttat tgtatctatt gtttgtgcga ttttcgttat gttggggttg 720
tttagttttg gtgttgacgt cgatttgaat tttagaaaaa ttgcgcatta tcctttggct 780
atgctctgca tgatcttagg aatatttttc agtattttgt tttcaatttt tctagataaa 840
tatacctacc tatcaactat cttgagcagt attggtaaat ctacgttatt gattctttta 900
tttcacaatg cgattcaaaa tcatttaatt ttcacaattg gtgattcaaa aatatatagt 960
gctgtgatcg gcattgttat cgcaatattg atacctatag tacttgataa gtttgttgtg 1020
aataaatacg aattgttcag aaaaatagtt tacccaaaac tatctatcaa ccttgcatcc 1080
aagataatgg tagggaaaag attttga 1107
<210> 138
<211> 1098
<212> DNA
<213> 糖原甲基菌
<400> 138
ttgattgtat atattaatgg ccgattttta ggaagacgca taactggggt tgatcgatac 60
gcaatagaag tattaaaaga gttaaataca ctgattgcgg aaaatcatcc cagtgtagct 120
ggtgttgaat ataagattgt tattcctcct cgcatcaaaa ctgacttgca tctaactcat 180
atacctatag tggcttatgg tttttttagt gggcatgcgt gggagcaatt gtccctacta 240
atgttgagtc tgagtagtaa gtcaatggta ttaaatttat gtaatacagg ctcaatcttc 300
gtgcgtagtc aaatcgtcgt cattcacgat gctgcagtgg tgagaattcc tagtacattt 360
tctttagcat ttcgggtgtg gtacaaaaca ctcatgccag tactcggcag agtcgcaaag 420
aaaattgtaa cggtttcaga atattcgaaa aaagacatta ttaacttttt tggtgtacat 480
cctgaaaaag ttcaagttgt tggtgcaggc ggcgagcata ttttgtcgca acagccagac 540
gcaggtattc ttgaaaaatt tcaagttcac ccgggctctt atgtgttggc ggttagtagt 600
catgctccgc acaaaaattt ttctttaacc attgaatctt taaaactttc taagaatgca 660
aatattccgt atttgattgc aggtggggct aatcagaaaa tttttggtga aaattcccag 720
ttagattctt ctaaggtgac gttgctgggt tatgtctcgg ataatgagtt gcgcgcgctt 780
tatgaacatg cgctttgttt tgtttttcca tcactttatg agggcttcgg tcttcctcca 840
ctggaggcga tgaattgcgg ctgccccgta cttgcatcaa atgctgcatc aattccagag 900
gtgtgcagtg atgctgcatt atatttttca ccgcatgatc cgcaggagct ttcaaagctt 960
atagataatg ttgctcatga tgccgatttg agaaagtcgt tagtcaacca aggcttgaag 1020
cgagcaaaag atttttcttg gaaaaattcc gcaatagata ttgcacggat gtgcaaggag 1080
attttcacaa taaagtaa 1098
<210> 139
<211> 1155
<212> DNA
<213> 糖原甲基菌
<400> 139
atgactaata aatatacgag gcattcgaga ttgcacccaa aaaaagtagc tatcgttgtg 60
gattggctta atgaatatgc tggagcagag cgtgttctgg agcagttggt tctttgctat 120
cctgatgcag acatttttgc tgtcattgaa ttcttacctg ataacctgag aggttttatt 180
cagaataaga aggttacgac aacttttatc caaaacttgc ctaaagctaa aacgcattat 240
cgcaattatt tgccactaat gcctttagct attgagcagc tcgatctgtc tcaatatgat 300
ttgattattt ctagttctca cgccgtggcc aagggtgtgc ttactgggcc agatcaagtg 360
catgtaagtt atgtccattc tcccatgaga tatgcgtggg atttgcaaca tcaatacttg 420
cgtgagtcta atttggtttc aggttttaaa tcttggattg tcaaatggtt gctacataaa 480
ttgcgtattt gggatctaag aacggcgaac ggggtagatg tttttatcgc aaactcttct 540
tttattgcta aaagaataaa gaaggtatat ggacgtgagg ctagggttat ttatcctcct 600
gtagatacca acagttttgc attccaggaa aagaaagatg actttttctt gactgcctcg 660
agattggtac cttacaaacg agttgacttg attgtggaag ccttttccaa aatcccagat 720
cagaaattag ttgtcattgg ggatggtcca gacatgtcca aggtgcgtgc aaaagcaggg 780
ccaaatgttg aaatcctcgg ttatcagtct catgctgtgt taagagacta catgcagcgt 840
gcgaaagggt ttgtcttcgc ggcggaggaa gattttggta tttctcctgt tgaggcacaa 900
gcatgtggta ctcccgtgat tgctttcgcc aaaggtggcg ccttggagac agttattcca 960
gaagagcgag gtgatcctgc cactggtttg ttcttccatg agcagacagc tgatgccatc 1020
gtggatgcta ttactagatt taatctactc tctcaaaaga ttagtccatt tgcatgcaga 1080
gagaacgcac tgcgcttttc tcctgatcga tttagaaatg agattatttc aactgtgaat 1140
aaggctctcg attaa 1155
<210> 140
<211> 1167
<212> DNA
<213> 糖原甲基菌
<400> 140
atgaaaatag ctgttgcagg tactgggtat gtgggcttgt cgattgctgt gcttttagca 60
cagaaaaatg aagttgttgc tcttgatatc gtccctgata aagttgacct tatcaacaat 120
aaaatttctc caatcgttga taaagagatt gagcattatc ttaagaatat tccattgaac 180
ctacgtgcga ctacaaacaa gcatgatgca tatgaaaatg cagattttgt agtgattgca 240
acccctacgg actatgatcc ggttaccagc tacttcaata cctcctctgt agaggcagtg 300
atcaaggatg tccaggcgat tgcgcccaac gcgaccatgg tgatcaaatc caccatccct 360
gttggttata ccaaaatgat ttccgaaaag ttgggtgtgg ataacctgat tttctctcct 420
gaattcttgc gtgaaggtaa ggcactttac gacaacctgt atccctcgcg tatcgtcatt 480
ggtgaaattt cggatcgcgc acaagttttt gccgaccttc tcaatgcagg tgctgtgaaa 540
gagaatattc cggtgctatt gaccaatagt gctgaagcgg aggccattaa gctgtttgcc 600
aacaccttcc tcgccatgcg cgtcgcctat ttcaatgagc tggatactta tgccgccacc 660
catggcctga acacacgtca gatcatagat ggggtgtgcc tagacccacg tgtcggtgac 720
cactataaca atccatcgtt tggctatggt ggttactgcc tgcctaagga taccaagcaa 780
ctgctggcca attacgacaa cgtgccgcaa aaactcatca atgccattgt tgatgccaac 840
accacgcgca aggatttcat cgcccagagc atcatcaagc gtgaccccaa ggtggtgggt 900
atctaccgcc tgatcatgaa agcaggctcg gataacttcc gcgccagttc aatccagggc 960
gtgatgaagc gcatcaaggc acgtggtatt aaggtcgtgg tgtttgagcc tgagttgaaa 1020
gaagatcaat tcttcaattc agaggtgatc cgcaatctgg aagagttcaa gaagatttca 1080
gacgtcattg tcgccaatag aagggcgcag gatttgtcag acgttgatga gaaagtatat 1140
acgcgtgatt tgtttggcaa tgactag 1167
<210> 141
<211> 972
<212> DNA
<213> 糖原甲基菌
<400> 141
atgaggatac ttttttcacc tgctacggcg agtaatcagt atgtcgagaa cacgattgcc 60
ctgattaaaa ccctagacgc tacccatgtc gaaacccaag ccagattgaa tgctggattc 120
atcttgcgca atgctttcaa ccgctatgat tgcattatca tcaactggct ggaaaacaac 180
ctggttggaa aaaacaagtc gcttgatata tgggcggtag caaaatttct gttcaagttt 240
ttcatctaca gagtcatggg gagaaagttg atttttgtca ggcacaatat ttatcctcat 300
gccttgaagg gtcggcaggc atccatcgcg acctggatca ttgaagcggc gattaagctc 360
tcaacaatat ccgttgtaca ttcagggcat ctcgaaaatg agaacgcgaa atatgtacct 420
catcctttgt acagggttga ttcgcaggtt gaaggccaag gcagtgatta ttatgtaatt 480
tttggcagga ttgttgcgta taaagccatc cataaattac tcgaaagctg ggggtcgcag 540
cggctaatca tagccggcat tgtcgaggat catgcctacg ctgccagctt gcaatccatc 600
atacagtcca gagggttgag caatgttgaa ctgcgtgctg aattcctctc cgaagccgag 660
gctgaacaac tggtagctaa cagcaagggc ttgattcttt cacattgcga tgccgacatg 720
attgtcagtg gtagtttttt ctttgctgca agtctgggcg tgcctgtttt tgccatggat 780
actccatttt tccagtggct gaagaatgag caaggctatc agggcttgca ggtgttcaca 840
tcactgcagg caatgacggc tgagctagcc actgccgcgg ccgtggaaaa aaatactatt 900
gctgcttcag cccagcgttt atttggcaat gatagggtga gaagtgcatg gggtagtgtg 960
ctccatggtt aa 972
<210> 142
<211> 1413
<212> DNA
<213> 糖原甲基菌
<400> 142
atgaccacga taggtcagga tgttaaccag cctgcaggca ttcctgaagt atttacaatc 60
aatgatgtcg ttgacagagg gctatgcgtt ggatgtggtg cgtgcgcggt tgtagattca 120
aacgtcaagc taacgcgcaa tcaatatggt tccatggtgg ccgccattga tgccaatatc 180
ctgccagggt ctattgccga ccgggtatgc ccattttctg ataacagtct taatgaagat 240
gttgtgggag aacgggtttt tgcgagttgt gaaaattttg atcaacgtac cggttattac 300
accaatttat attatggccg caggttcact gaagctgaat tgctgaaaag cagttctggt 360
gggctgacca gttatgtcgc cattgaactt ctcaagcgtc atcacgtgga tggcattatt 420
catgtgggac gcgaccagtc agatgatcgc gatgctttgt tcaagttcat ggtgtcttac 480
acagaagaag acgccaatgc ctgcaagaaa tcacaatatt attccctgag ttttgatgag 540
gtagtaagaa gcatacgcgg agatggtaag cgttatgtat ttgtgggcgt gccctgcttt 600
gtcaaatctc tgagaaatat ttgtctcaat gatgctgtgc tcaatgagca gattccattc 660
atgctgggct tggtgtgtgg tcatttgaag tcttcgcgct ttgccgaatt actagcgtgg 720
caacttagtg tgccaccgga aaaaatccag agtgtggact ttagagtaaa aaataatgcc 780
tccaccgtga attcctacga tttccaggtg gtggatagca atcagcaagc ccatgcaaaa 840
acctctaata caatgctggg cggcaattgg ggccatgcgg cgtttcaact tcaggcatgc 900
gattattgtg atgatatatt tgccgagaca gcagacgctg tctttggtga tgcatggttg 960
ccgcagttct ccacatggtg gcaaggtacc aatatcgtcc tggtaagaaa ccctatcatc 1020
gacgacattc tggaatcggg gaaaaatgca ggcgccatca ctctgggcgg tgtcagcatt 1080
gatgatttat gcaagtcgca gttgggtaat ttccgccaca gaaaagatgg tttgattgtc 1140
aggttagacg atgacctgaa gcagggcaag aaggtcccca aaaaacgggt tgatctgtct 1200
gcattaggca agattgacca gaagagaaag aaaattgtca ggctcagaaa ggaaatggcc 1260
gtgaaaagtc acgaatattt cctgcaggcc cgagaaaagc acgatctcag cctttatatg 1320
aagcccatgg ggcagttggc gagaaatatg cttaagctgt atagggatcc atttatgaag 1380
cgactgatca ataggctgaa gcgatatttt taa 1413
<210> 143
<211> 1449
<212> DNA
<213> 糖原甲基菌
<400> 143
ttgagtctat ctgtaaaagc cgcgcgcggt ggtgtggtca tgatgtcagg acaaattgtg 60
aaggtagctt tgcagtttgg cagcctgatt atcttggcac gcctgttgca accagaagat 120
tttggtttgg ttgccatggt gattgcgatt tatggcattt gcgacatctt gctcgacttt 180
ggcctttcga cggcgtctat tcaagtccaa aacataacta aagcgcagat cagcaacctg 240
ttctgggtca atgtattgat aggtctgttg tttacgctga tttcatactt ttcagcaagt 300
ttactggcga gcttttatgc tcagccagaa ttaaccaaaa ttgcgcagta tgtttctgtg 360
gtgtttttat tcaatggtat tgccgcacaa tataaagccc agctgaaccg taatttcaaa 420
ttcaaacaga tggcaataac agatacgact gctgttttgc tcagtgtttg tatcggggtc 480
tatttcgcat atgccggaca ttcttactgg gccatcgtat atcagcagat agcgcaggca 540
ttgatacaaa tgcttttgta catgcttttc ggcgcttggc taccttcctt gccttcaaga 600
catgtttcta tcagacattt cttcaaattc ggttgggggc tggctggttc tcaattgatg 660
ggatacttct cgcgcaatat tccagctatc ttgattggta atcaaatagg tgccagccag 720
ttggggtttt acgatagagc caacaaatta ctgatgttgc cgctaaacca gctgaatgcg 780
ccttcatcgt cggttgctgt ccctgtgttg tcacgtttgg cagtggaaga tcaggaaaaa 840
tacaatcgtt ttcttctgtt tggacaaaat atcattgtcc atctcgttgt attttgcctg 900
gccttaacct gctgccagac agagcgcctg gtgcaattgg tgctcgggac acaatggttg 960
gaaatggtgc cggtctaccg ggcactttca tttgcaggga tatttttggc gctcagctat 1020
gccagttact gggtattttt atctaaaggg attactgcct ctctatttaa actaggcttg 1080
gttagcaggc caatctctat tttgattatt tgcctggggc tgcccgctgg tgtgattggc 1140
gtagcgtatg catactcggc aagtctgctc tttacctggc tactcggcgt tttctggctg 1200
aggaaaacgg gcgttcctgt caaaagcatg attgtagatc cactcatcat gtctgccatt 1260
tactatagcg ccagttttat cgccaattac gtggtcgatc attatgtgga ctttgccata 1320
tacaacattc ttgtcggctg gttgctgatg ttgctgatcc tggcagtatt ttatttgttg 1380
gtccccaagt tcaaacgtag cgtgaaaaag ttatttgaag tgaaaagtta tattcggaac 1440
aaacaatga 1449
<210> 144
<211> 1206
<212> DNA
<213> 糖原甲基菌
<400> 144
atgaagacca ttaaaaaatt actatacaaa atcctaggta gtgcaggcat caaggccaag 60
gctgcagcag tcatcaatct cctgtttggt cgtgtggcta gaagcactaa tgacagtgtc 120
tctattctta ttccggcacc aggagggggg aatatcggtg atcaggcaat gctggaatca 180
tttttgcata atattgatgg caaaaaactc attatcaaaa cacagcctat agcattggat 240
attcctagtc actatgcagt gaacgttgaa gtgatcgaaa tgccaggatt gatctacggt 300
catttgttca ggtttttgcg ggattacgta agactgagaa aaataatggc atctgccagc 360
gctttgtatg tagttggcgc agatatcatg gatggtggct ataataaaaa tgcctctatc 420
atgcgctcta aaattgcaac ttatttcgcg cgtaataata ttccatccag ggtgtttggt 480
ttcagttgga atggcaatcc tgatgcagca gcgctttctg ctatcagaaa cgcagctgcc 540
aatggggttt tgctttgtgc gcgagatcct ctttcattcc agcgtctaca agatgcaggg 600
gttcccaata tcaggctggt tgcagatatg gtgtttgcca atgacaacac caaatcagct 660
gggattgaag atattttgca attctgcgca ggcaagcaga ttgctctggt aaatgccagt 720
ggattgattg gcaaaaatat tgatcaaatt gatgaatata gcaaggtaat aaacaagctg 780
atggaccaca attttaatat tgtactattg cctcacgtga tcagacacgg agccaatgac 840
ttgccgattt gtcaggcatt gtcaggcaag tatccgaatg ctttcctagt aaatagactg 900
ttggaaccag atcaggttaa gcgcttagca caagaggcta aaattgtcgt caccggtcgc 960
atgcatcttt ccatcatgag cctgaatcag aatgttccat ctatcgtatt atcgacccaa 1020
ggcaaggttg atgggcttat gcaattcttc gaaactgaaa aactgtcgat taatccggaa 1080
aaaggttttt ccgatcttat ttgttcacaa attgatttta tttgttctaa tcggcaatat 1140
tatcaagacc tgattcgtaa aaacctactt aaggttaagg aactggccgc tgggaatttt 1200
aattag 1206
<210> 145
<211> 1188
<212> DNA
<213> 糖原甲基菌
<400> 145
atgtctaaat tctataaatt tcaggtgtta gaatcactaa gaggttatat ggcatggtgg 60
gttgttttag gtcatgctat ccaactttct ggtttttggc acaagcaaga agtagatgag 120
ttttttacag gagggggcat aattaatgcc actttttcaa aaatactcag tttaatcatc 180
aatccagaac ttgcagtcaa catttttatt attttaagtg gttttgtgat tactcattta 240
ttgcttacta aaaatgagcc atattcacat ttcataacta gacgattttt ccgcttggcg 300
cccgcatttt acgtttcgtt agttatcgcg attttggtag ttaattttta caaggttgca 360
tataccggtc tgagtttttc tggtgatacc tcgatgcgac tcgccaggct tgttgagcaa 420
gatagtaatt ttttattgca tttattcaat catttactcc tcattcatag cgttttcccg 480
caagagctga ttcaattttc acctaccacg tttcttgctc cggcatggag catcagtctt 540
gagtggcagt tctatctaat tgcaccagtc ttaattccat ttttggtgaa gtctgagaag 600
tctttgattg tttgggttgt gttgttgcta ctgctgcgat attttaccaa ccatgtttta 660
gactttaatt ggcaacatag ctccttcttc tttaaagctg tcgattattt cttggtcggc 720
atcttaagca gattaattat cgagcgactg cagcatggca agtttattta tgatgttgcc 780
gtgttgctag gtggaatatt gcttttccag gatagatatt gcgctgttat ctggctgttt 840
gttttggctg tcatatttta tgaaatgggt tattggagtg ttaaatctcc cctatggaaa 900
aaaatcctga cattattttt ctacaataaa gtcatcacga atattggtaa gtggtcttat 960
tctacttacc taatccatat tcctattttc tcaattttct taggtggtta tgcaactctg 1020
actgaccctg gcactgtaac ccagcaaatt tctttgatta tcctatttgt cagttttcca 1080
gtggttttgc tgatttcaaa tattatgtat cacaacatag agctgccatc gatgaattat 1140
atttccgcaa aactaaaaga aaaacgtatc actgaatctg cagagtga 1188
<210> 146
<211> 1407
<212> DNA
<213> 糖原甲基菌
<400> 146
atgaaaattg ttcctgtatt actctccggt ggttctggta cacggttatg gccactttct 60
cgagcggtat tacctaagca actgttgccc ttgatcacta ataaaaccat gctgcaggag 120
acccttctca gaatttcaag atgggcgact gtaacaaatc cagttgttgt ttgcggtaac 180
gatcatcgat tcttagtggc tgaacagttg cgcgaaatcg ctttgagtcc taactctatt 240
attctagagc ctgcccccaa gaatactgca ccagctattg ccgctgcagc attgcagcta 300
caaggtcagg atgtttatat gctggtcttg cctgctgatc atgtcatcag ggatctgcaa 360
agttttgaac atgctgtgca aaccgcattg actgccgctg atcaaggtaa cttagtcacc 420
ttcggtatca aacctgctca tcctgaaacc ggttatggct acatcaaatt aggcgttgag 480
agcgcaccag gatcttataa ggtcaatcgt tttgttgaga agccagatct tgccacagca 540
actgaatatg tggcgtcagg tgagtttttc tggaacagtg gcatgttttt attcaagcca 600
gaaactttcc tcaagcaact ggaaatccat gcccccgaaa ttactgctgc agtaagcaag 660
gccgtcaata acagttataa ggatctggat ttcgtcagat tagaagaatc gagttttgct 720
gagtctccgt ccttatccat cgattatgcg gtaatggaaa aaaccgatca tgctgttgta 780
gtgcctgctg atattggttg gagtgacgtt ggctcatgga cgtctctaca agaggtgcaa 840
gagcaggatg ccaatggcaa tgtagctcgt ggcgatgttt acctcaagaa tgtcgagaac 900
agtctggtgc ggagtgagga taggtttgtt gccgcgattg gtgtccgtga tctgatcgtg 960
gtggagacca gtgatgccgt tctggtagct agcaaggatg ctgcacaaga tgtcaaggag 1020
gtagtggaat acctcaagtt aaatcaacgc tctgagcaca agatacatcc acgggcctac 1080
aggccttggg gttggtatga aagtattgat ctgggcgagc gccaccaggt gaaacgtatc 1140
atggtgaagc cgggcgaaaa gctgtccctg caaatgcacc accatcgtgc cgagcattgg 1200
gttgtagtca gtggttcagc catgattacg gtggatggga ataccaagct attcagtgaa 1260
aatcagtcaa cgtacattcc aattggctcc acccatagat tggagaatcc gggcaagttg 1320
ccgctgcact tgatcgaggt tcagtccgga agttatctgg gcgaagatga cattgtgcgt 1380
tacgaggata cctacggccg gtcctga 1407
<210> 147
<211> 333
<212> DNA
<213> 糖原甲基菌
<400> 147
atgcttacgg atgaataccg atacaagatt ctgaaattgg tgcaggaaaa accagatatc 60
agccaaagag aactggcgaa agcactaggc attagcttgg ggaaaaccaa tttttgtctc 120
aaagccttag cgcaagttgg cttgctcaaa gtatctaatt ttcgcaacag caagaataag 180
ttggcatata tgtatgtcct cacgccgaca ggcatagaac ataaagctgc tgtgacactc 240
aactttctca aactcaagct caaagagtac gaacaattag caggagagat tgaagagtta 300
cgtagtgaga tcaacgctaa ggtaaatgat taa 333
<210> 148
<211> 1089
<212> DNA
<213> 糖原甲基菌
<400> 148
atgttaaaaa aagtagctct aattacaggt atcactggac aagacggagc atatctagct 60
gaatttttac ttggcaaagg ctatgtagta catggcatta agcgccgagc atcacttttc 120
aatacagatc gcattgatca tctgtatcag gaccctcacg tcgataacca gaatttcatc 180
cttcattatg gggatttgac agattccacc aaccttatac gtatcattca gcaggttcag 240
cccgacgaaa tctataacct cgcggcaatg agccacgtgg cagtcagttt tgaaagtcct 300
gaatatacgg ctaacgcgga tggtcttggg actttgcgta ttctggaagc tatccgcatc 360
ttggggctgg aaaagaaaac ccgcttttac caagcctcga cctcagagct ttatggtttg 420
gtgcaggaaa caccgcagaa agaaagcacc ccattttatc cacgcagccc gtatgcggtt 480
gcgaagcttt atgcatattg gattactgtc aattaccgcg aagcttatgg catctacgcc 540
tgtaatggta ttttattcaa tcacgagagc cccttgcgtg gggagacctt tgttacccgt 600
aaaattaccc gtgccttggc gcgcatcaag ctgggcttgc aagattgcct ttatttggga 660
aatctggacg cgttgcgtga ttggggtcac gccaaggatt atgttgaaat gcaatggctg 720
atgttgcaac aggaacaggc agaggatttc gtcattgcga caggtgtgca atacagtgtg 780
cgcgatttcg tcaatgcagc cgcccacgag ctggatattg ccatcacctg gaaaggtcag 840
ggccaagaag agatgggata cgacggtcaa ggcaggtgca ttgtacaggt tgacccgcgc 900
tattttaggc ctaccgaagt tgaaacattg cttggtgacc cgagcaaggc aaagcaaaaa 960
cttggctggt cgcccagcat cagtttccag gagttggttt ctgaaatggt gcgtgaagat 1020
ctcaagagcg cagagcgtga cgaactggtt aagcagcatg gttttgctgc ctatgactat 1080
aacgagtaa 1089
<210> 149
<211> 974
<212> DNA
<213> 糖原甲基菌
<400> 149
atggacaaac acgcacgtat ctatgtggca gggcatcgag gcctagtggg ttccgctatc 60
gttagggggc tagagggcaa gggctatagc aatcttatca agcgtaccca tgcagagctt 120
gacctcacag atgctaatgc cacggaagca ttctttgctc agtatcagcc gaatatgttt 180
tcctggcggc agccaaagtg ggtggcatag tggccaataa cacttacccg gcagatttta 240
tccgtgacaa tctcgcaatt cagaacagtg tgatccatag tgcctggaag catggagtaa 300
agcgcctatt gtttttaggg tccagctgca tataccccaa gcatgctcct cagcccatgc 360
atgagcacca ctttctaacc ggatcgcttg aagctaccaa tcgtgcatac gcgctggcaa 420
agattgctgg agtcgaaatg tgctggagtt ataaccggca gtatggcact cgatttcttg 480
cagcaatgcc gacaaatctt tatgggcctg gcgataacta tcacttgcag aatagtcacg 540
ttatccctgc attgatacgc aaattccacg aggctaaaca agctgggcat gcagctgtat 600
cggtctgggg tactggaaca cccaggcgcg aatttcttta cagtgaggat atggcagatg 660
cctgtatatt cttgctgaat ctgcctgagg agaaattcaa ttctctgctg ggaagtgatg 720
agagtgctac tggtgtgttt gatccaccac tagtcaatat cggtattgga gtcgatattt 780
caatacagga attggccgaa ttggtaaaaa aggtggttgg ttaccaagga gcaattgagt 840
tcgatagttc aaaacctgat ggcacgatgc gtaagcttat ggatgtaagc aagctcaaca 900
gtttggggtg gacttattcc attgagcttg atgatggatt ggaaaagaca tattcggaat 960
ttttaacaaa ataa 974
<210> 150
<211> 696
<212> DNA
<213> 糖原甲基菌
<400> 150
ttgaaaaaaa aagtgtttgc tttgattcct gccagagcag gttctaaagg agtgccaaaa 60
aaaaacctga aaaatatcgc aggttctcca ttaatagctt acacaattaa cgctgctaaa 120
aaagctaaaa atgtcgatgc tgtttatgta tcttctgatt gtaaagaaat attggagtat 180
tcaaaagcac aaggctgcag ttcaatatta aggccgcaag aatacgcaac agatgatgcg 240
tcagctgttg atgttgtcaa gcattttatt agtattgaaa atatagagga tggagattta 300
atcgtttact tacagccaac ctccccatta agagatgaac atcatattga tgatgctttg 360
acggctttga ataataatgg ccttacttct ttggtcagtg tggaagtctt ggataagtcg 420
ccatataagt catttcgtct agatgataat gataaattga tttcattatt tgatgaaaaa 480
ttatctaatt atcgtcgtca agatttgcca ttatgttacg cgccaaatgg tgctatttat 540
atcttttcga aatttgaatt tgaggctaga ggcggtttcc cctccaatgg tagtgttgct 600
tatattatgt ctgctgaaga aagtgttgat attgacaccg aagaagattt tttagaaaca 660
gaagcattat taaggaaaaa atatggcatc ttttga 696
<210> 151
<211> 1041
<212> DNA
<213> 糖原甲基菌
<400> 151
atggcatctt ttgaaatttc tgggcggaaa attggggacg gacatgagcc tatagttatt 60
gcagaaattg gcatcaatca cgagggttca ttagatcttg cgattgatat ggcaaaagct 120
gcaattgatg ctggggcaga gataataaaa catcagacac atgtggttga agatgaaatg 180
tctgatgaag ccaagagtgt tattcctgga aatgcggatg tttcaatcta tgagattatg 240
caacgttgct cattgtcaga ggatgatgaa tataagctca tgcaatatgt gcagcagcaa 300
ggcagtattt ttattagtac gccattctcg agaatggcag caaatcgact gagaaaattt 360
gatataccgg cttataaaat tggatctggc gagtgcaata attatcctct cgtgcggcat 420
attgcttcat ttgggaaacc tattattgtt agtaccggta tgaatagcat tgaaagcatt 480
gcaccaaccg tcaatatatt aaggcaagca aaagttcctt ttgctcttct gcactgcacg 540
aatatttacc ctacccctcc tgagcttgta agacttgatg ctatccaagt cattaaaaat 600
gcatatcctg atgcggttgt gggactttca gatcacaccc ttgggaatta cgcttgccta 660
ggggctgttg cactaggagc ctcaattctt gagcggcatt ttactgactc catgtcacgg 720
ccgggaccag acattgtttg ttcaatggac cctgcagcat tgcaagattt aatcactggt 780
tcaaaagtta ttttttcagc aaaaggtgca cataaaggtc cacttttaga agaagaaaaa 840
actatagctt ttgcttttgc atctgtcgtt gcaattaagg atatcaatgt tggtgatgtc 900
ttaagtgaag ataatatttg gttacgtagg ccaggtggcg gtgattttaa tgcttctgac 960
tatgatcagc tacttggtcg taaagcatcg caaactatac tgagtggcaa aagagttaat 1020
cggcaggata ttgaggcatg a 1041
<210> 152
<211> 1132
<212> DNA
<213> 糖原甲基菌
<400> 152
atgagtaggc gagttgtttt tcttactgga acaagagcag attttggaaa actgaaatcc 60
ctcatgcgag cattacaaaa tgacatggga tttgacgtcc atgtgttcat tactggcatg 120
catatgttgt cgaaatatgg ttatacatgt gaagaagtag aaaaagccgg atttaaaaac 180
ctatttcgct ttatcaatca aaatcaaagc gatagcatgg atcatattct ggccaaaaca 240
attactggtt tatcagatta tgtaaaagaa atttcaccag aactgattgt gattcatggg 300
gatagagttg aagcgttggc cggagccgct gttggcgcat taaataacat tcgagtggca 360
catattgagg gcggagaggt ctctggcact gttgacgagt tgattagaca tgcggtgacc 420
aagctgtccc atgggcattt tgtttccaac gaacaggcaa aaaatcgact tattcagctt 480
ggagaaagtg aagaatccat ttttgttatt ggctccccag atattgatgt tatgaattca 540
acatcgctgc caagcattga tgatgtgagg gaacgttatg gcttctcgtt cgaacattac 600
ggcattttga tgtatcaccc cgttacctct gagttagatg atttgccaag acaagccaaa 660
gccatcgtag attatatttc agaaagctct ctaccattca ttgttgtata tcccaataat 720
gatcatggtt cagacattat tttgaatgag tatttgcgat tgaaaaactt gagccacgtt 780
agagtttatc catccattag atttgaatat tttttaacgc tgctaaaaaa atgcagcgtt 840
catcatgggt aactctagcg ctggagtaag agaggctcct catttcggcg tgccagccat 900
caatgttggt agcaggcaac acaatagagc aacagcagag tcgattctta atactactgc 960
acatgtggat tcccttagac atgctgttca acaagttgca gacattcctc gcgtggcagt 1020
ttctgacttt ggtaatggta atagtgcagg tgagtttcat cagattctgt tgaataatgc 1080
tttttgggat aagggcatac aaaagcactt tatcgatagg agtgcagtgt ga 1132
<210> 153
<211> 738
<212> DNA
<213> 糖原甲基菌
<400> 153
gtgaggttga tcgcaaggct agatgtcaaa aatgaacatg tgattaaagg catacaccta 60
gagggcttgc ggaaagttgg cgatccaatc gagatggcga aaaactatta tgcacaaggc 120
attgatgaga ttgtgtttat agatgcggta gcgagcttgt ataaccgtaa taacctgctg 180
tctgtaatcg ccaaggcttc ggaagaagtt tttgttccta tcactgtagg gggggggctg 240
cgttccttag cagatgtcga gatggctctg agtgccggag cagacaaagt ggcagtgaat 300
acagctgcaa tacttaaccc gaaattcatc acagagattg ccaagcgcta tggcagtcaa 360
tgtgtggttg cctctattca agccaaacgg ataggcaatg actgggaagc ttatatggaa 420
gccgggaggg agcctacggg caaaaatgtt gttgcttgga gcaaggagct ggaagatctt 480
ggtgcaggcg agattttgct aacgtctata gaccaagatg gtacaaaaaa aggatttgac 540
cttccattgc ttggtgcagt taacacgata gtgaacattc cagtcatggt tagtggtggc 600
tgcggtaatc ctgatcatgt gcaagagtta aaagaaatcc agccaagtgg agtttgtctg 660
gcgtcagtat tgcattacaa aatcaatacg atagatgaat tcaaacagcg tctgacattc 720
atcaatggta ctaaataa 738
<210> 154
<211> 639
<212> DNA
<213> 糖原甲基菌
<400> 154
atgaagaaaa tatgtattct tgattatggg ctaggcaatg tgcgtagtgt gagtaatgcg 60
atcaagtacg taggtgctca tcctgtaatc tcaaatacgc cagaggcact taaagattct 120
cacgcgttaa tagtgccagg ggttggtgcg tttgctcaag gcatgtctgc attgggtaaa 180
gatggattac aagctagctt gctcgaatat ataaaaagtg gaaaacatgt cttggggatt 240
tgtttgggca tgcaattgct tttcgacagg ggtgaggagt ttggcgttac cactggtctt 300
ggacttgtgc ctggcgtagt ctccagaatt gtacccgtag agcaatcacg agtgaggtta 360
ccgcatatat cctgggcgaa agttgatctc aattccgttc atgaaaataa tggcggcatg 420
tttgatggac tgccagacga gcagcgtaag ttctattttc tgcacagtta tgccgctcaa 480
aatgtacctg atcgatacat cacaggcagc gcgacgtatt ctggatgtac ttttgttgca 540
tcagtgcaga aagacaatat ctggggtatg caatttcacc cagaaaaaag tgggcccagc 600
gggttacagg ttcttaataa ctttgtacaa aacagttaa 639
<210> 155
<211> 1227
<212> DNA
<213> 糖原甲基菌
<400> 155
ttgaaaagaa gtgtggagga agttgtggtt aatgcatatt ttggtttgcc ggaagatgta 60
gtgttttgca agaaatgcgt gatttccaac caaagaccca gttctacagt tgaattcaag 120
cataccaaca aggacaaaaa agcgaccata ggatttggcg ctgatggtat ttgtgatgct 180
tgccgctatg cagaaaccaa ggatgctcaa atagactggc aggcccgcga ggacgctttg 240
gttagattgt tggatcaaca tcgccgtagc gatggtggat atgacattgt cgtgcccggc 300
agtggtggta aagacagtgc atatacctca catatcctta aatataaata tggtatgaat 360
cctttaacag tgacgtgggc gccgcataag tacactgaga ttggttggaa gaattttgaa 420
aactggatcc ataaaggtgg attagacaat attcttttta ccccaaatgg caagttgcac 480
cgctatttaa caaaaatggc atttctgaat ttattgcacc cattccaacc attcattgtt 540
ggccaacgca ttatcgggcc gttgatggct aaaaagtttg gtatcaaatt ggtaatgtat 600
ggtgaaaatc aagctgaata tggcaataag acagaagaaa actataaacc gacaatggac 660
aagaattttt tctctatttc agacccagct gacatggtgt taggtggtgt gaaggttgga 720
gacattatta aagacggtga atacagctta aatgatttcg cgccatatat tccgcctgct 780
gcagaagatc tagagcgcga tggtatcgag gtacattatt tgggctatta cctgaaatgg 840
gatccacaag agtgctatta ctatgcagtc gagcatactg gtttccaggc aaatacggaa 900
cgcactgaag gaacctactc caagtacagt agtatcgatg atcgaataga tatgttccac 960
tactttacta ccttgatcaa attcggcatt ggtagggcaa catatgatgc tgcgcaagaa 1020
attcgcaacg ataaaattac gcgagaagaa ggggttgctc tagttcataa atatgatcaa 1080
gagtttccaa aaaagtactt tgcagaattc cttgaatata tagagatcac cgaagcacag 1140
ttttgggaaa ccgtagatag gtttagatct ccacatttgt gggaaaagca agacagtaat 1200
tggatactga agcatcaggt gacctaa 1227
<210> 156
<211> 1194
<212> DNA
<213> 糖原甲基菌
<400> 156
ttggatactg aagcatcagg tgacctaaga atgaaagtgt tgcagatagg aagtttctcc 60
ggaaatgtcg gtgacattgc caaccattat ggttttcgca attggtttca aggactgctt 120
ggagagattc aatgggatga attcgaaata cgcaatgttt accgaaaaaa tgttgccttt 180
gacgataatt ttgtagctat tgcaaatcag tacgatctta tagtcgtggg aggtggtaat 240
tttttcgagc tatgggttga ttcttctcca accggcacct caatctcaat tgagattgag 300
gtttttaaaa aaataaaagt ccccatcttt ttcaatgcat tgggtgttga tgatggtatg 360
ggatgtagtg atgaaagtct tgcaaagttt actaatttct tagaaatctt aacttcatca 420
aagcaatatt tggtcagtgt tcgtaatgat ggagcaatgg gcacgctcag aaatcggatt 480
tctaataatc ccatgttgga taaagtctta ccattgcctg acggtgggtt ttttgtaaat 540
ctggataagt tagaaaaaga cattgcggaa aatgatcatg aaaacactca gatcaccatc 600
ggcatcaatc tggctggaga tatgttggaa acaaggtttc caggtggaat taatggatat 660
gattactcag gatttatatc cgagttcacc gagactttgg ctgaaatgtg gaataaaaat 720
aaattaataa agtttatttt ttttccacat atttatagtg atcttaaagt atatgccgac 780
atactatcac ggttgcctga tgcatgtaga cgtgaaaatg tcaaagtggc cagttacgat 840
actaatgtga attttcaagg gacattattt tccgaatata gcaaatgtac tttgatactt 900
ggtatgcgat ttcatgccaa tgttgtagcc atagctaata aaattccagt aataggattg 960
tactcataca agcaaattaa agaattgttt tatgagttgg gaataaaaga aaaaattgtt 1020
gatgtcagac aaataggttt taaaaatgaa ttgttgagaa agtgcaatat tgttattgaa 1080
aattcatcta tatctcgtga tgagagctgt aacatacttg atgttgtcac aaaaaaacgt 1140
gatttgattg ctccaagggt agtggagtgg ttacgtgagc ataagcttaa atga 1194
<210> 157
<211> 1068
<212> DNA
<213> 糖原甲基菌
<400> 157
atgattaaaa gccttgatta tctaagggcg attgcagcac taacggtttt tctcagccac 60
acctttcaaa tttattggtt accaaccatt ggattggtgt cctggaaata tgagttgaat 120
cattttttga gtgaaaccgc ggtcctctta ttttttgtat taagtggcta tgtaatttcg 180
aatagtttgc atagcaatac tcaacgtaat ggagggcgtc tttcagtact tgattacgca 240
tctagcagat tattgcgcat atatcctcct ctcattgtaa gcataataat atctttagtt 300
gcctatagtg tgattgtgat ctttgaacta ccgggatcag tgggtacttt aaaggcacca 360
ggagatatct atcaggcaag agactacttg agcattggta cgcgagacat tgtcaattct 420
ttattgatga ataatggctt gttgcaaatg aatgggccat tatggagttt atgcattgag 480
gctaagctat atttttatgc ttgtttagtt gtaataattt ttattcatta taaacaaaaa 540
aatttgctca attttattgc taatactggt tttctcgtat tatctgtatt cttgtttttt 600
aatacaaaaa ccgatattta ttatggctta tggtggttga gcggtggtgt aattttctta 660
tatcgtcgaa atttcataaa gttcatgact ttggttgttg taatggctat tgtggtgttt 720
gctatggcag tgattggaca gaagttcgtt tctttgccag tgcaagttat atttgtatat 780
tctttatttt tggcagcaat aaaatgcaaa gtgccagaaa ttaaggcaat gaatattttg 840
gccaatactt cgtacacttt atatattgtc catttcccta tgttgttact atcgtacgcc 900
atcttctcat ataactttga tgtgtacggt agcctgacta gagagttgat gtcatcatta 960
tcgctaataa tcatcttaac tatgtcaatt tatattggaa aatgggtaga gcgtccagct 1020
aatttacgtt tgacctatca caggttgttg agaaaagtaa aagtatga 1068
<210> 158
<211> 1680
<212> DNA
<213> 糖原甲基菌
<400> 158
atgaaagcca tgttttattc tttgcatgca gctatttggt tacatgcgct tcctgaaagc 60
cggttggcat cacagctgag taatgccggc catgagttag tatatgtgac ctgtgataaa 120
agctttactc attattgcac tggtatgagt gctttcaatc ttgcattgaa tgaggatttt 180
aaaaagaaaa gtgcaatttg tgagttatgt attaataacg ccaataaaat aaccaagtct 240
tttgattgca agcatcttaa attgcatgat tatattgatc agaaaactaa tgctctgatt 300
gataacctat tgaaaagtgt cacggaagat aatttcctcg aatttcatta tgaagatata 360
ccagtagggc gtttggctac atatgagcca cttcttaagt ataagaaaat gtctttggaa 420
tttagagatg aacaatggca agatctacag attcacctta ggaatgccct ggtatcgtta 480
atcggtttta tccaaatatt caaacaagag tgtccagaaa aaattttctt ttatagtcca 540
cagtatggtg ttaatggtgt gtgtgcagaa tatgcagtaa aacaggggag acaggcatat 600
tttatagaag gtagctctag caatgctgaa cgatatagtg ctttaagggt gtgggagtgg 660
agtaaattta aattagtaaa ccctgcattg cagcattggc aagctgttaa aaatttagta 720
acgcttgaag atattgatag agtctctgca catattcacg aattattcaa aggtaaatct 780
tttgctgttt tttcagcgcc aaaaacagga aatttttcaa tccgtgaaaa attcaatatt 840
ccacagaatg ctaaaattct actcgcctca ttaagtagtt ttgatgaagc gtatgcggct 900
tttgttatca aaggttttcc tgagcgtaaa gttaaaagtc cggttttctc agatcagttt 960
gaatggatta agtgtacaat taattttatg aagtctaggc ctgatgacta tcttgtaatt 1020
agagtacatc cgcgagacta tcctaataaa cgcgattcca atcagtctga gcaagcattg 1080
atttgggaaa aaatacttca ggatctccct gagaatgtta aattaaactc accagatcag 1140
aatatttctt tatacgattt tctcgatgat gtacatgcgc tggtaacagg gtggtctgcc 1200
actggtgtag aagcattgct acatggcata cctgtgatta cctatgataa atacttacct 1260
tcctatccgg cggatataca tctaacggga gagtctgaac atgagtatta tgacaacctt 1320
atcaaagtac tttctttggc aacatcaaca gataatacac atgtagttaa tgcctatcgc 1380
tggctcgcgg tcagtttttc actgggcact gtcagagtta atcagccact ggagattggt 1440
ctgagttggc cggataagcc ggcgtataga atattgaaaa gggtggctaa caagttttca 1500
gttaatttgc gaaaaagcta cgacgtatgg aatgtccagt ccaacgacac agaccgttta 1560
agatttttaa gtctggttct taataatcaa tctagccttt ttgagggtgt aatatctgat 1620
gtggtcgatg ctgtttccga ttatgaaatt gaagctacgg taaaacaaca ttcgatataa 1680
<210> 159
<211> 1707
<212> DNA
<213> 糖原甲基菌
<400> 159
ttgaataaat tgccacaagc aaaatatatt tttaagttat taaaatttgc tttcaataac 60
aacccattgt tgtatttgag tgttttaatt tctatacttt ctataggtat tgaattgttg 120
gcaatggcaa gcctattgcc tttatttgaa cttgtttcag gagaaacagt agataagcat 180
ggtttgattt caaaagctct gattatattg gggtttacag ttgatgctgc cagccttttg 240
caagttttct tcttattgtt cactttgaga gtagtcacgc aactatttag tcaaagcctg 300
acgcactacc ttggaagacg tgtgatggct cagctcggtt ctagggcttt tgaaaaaatc 360
attacttcga tgtcaattga taaaatatct gaaaaaagta taggtttttt tatggggctt 420
gctggagatg aatccttcag ggcgagtact ctggttgttg cattgactca gtttgttgca 480
acatttttac tgggggtaat gtattttatt tctattgcaa tttattcact atatgccgcc 540
gaaatgattt tcattttaat gcttgtgtct gccgtattct tcatttggat tttaaaaata 600
tctcataaga tgggcgtgag gcaaatagaa ggttcaagga aagcaaattc cattttcatg 660
gatgcgatga acaatatcaa agcagtaaga tcactttctt ccgagaagta tgttgccggt 720
ttgtataggc gaaagatttt tacgtatgca aatattcttt tttaccttga tgcaataaat 780
ctggctacga agttagtacc aataatattt ctattactcg gatctttggc tttgatattg 840
agtggctggg tttctgttga aaacttaggg atggcttaca ttgtgtcatt gatagcttat 900
ctcatgcgat ttttcccagt tgttggtcag agtatcactc tagctgttcg cattgttgca 960
gatgcgaaat cgggaaaaga tgtgacggaa ttagtttccg atgaaagtgc cgagagcgct 1020
aattcagaca actatttaca caagatagat acaatcaaga ttgataattt gtcgttttca 1080
taccgtgatg ttcaaggcgt aaggccagcg gttctcaatt ctgtttacta cgagtttgaa 1140
aagaacaact cttatgcttt agtggggaaa tctggtttag gaaagtctac tttgctggat 1200
gttttgctga agttttatcc tcctgcttca ggcagtattt caatagatgg tatttcaaca 1260
gaaaatatcc ctggagcaca tatcaggcat tctattgtac ttattaatca agaacctgcg 1320
atttttgatg atacggtcta caacaatatt tgtatgggcg agacttttac tctagaggac 1380
gtaaaatggg cttgcgaatt agcttgtatt tctaaagatg tggaaagtct tgcgcaaggt 1440
tatgaaacac gtttgcaata tcaaggaaaa aatctttcag gtgggcagcg tcagcgtata 1500
gctattgcca gagcattagt gcgcaaacct aatgtgctga tacttgatga aagtacaaca 1560
gctttagata aggctacaca agaaattgtg atacggaatc ttatgaatga gtatgaaaat 1620
aagatcatta tatttgtcag tcatgatcct tatatcatgt ctcaagtcga tcatacagtt 1680
gatttggcat taatcaataa agtataa 1707
<210> 160
<211> 699
<212> DNA
<213> 糖原甲基菌
<400> 160
atgtctatct caagtattgc tttaaaaata tttaattatt cgcaagagat tttttcattt 60
taccgggata gaggcttata taaattctct tatgcgcaag agggggaaga tttaattctg 120
agtagaattt ttgaccgaac ctctactggg tattatattg atataggtgc tcatcaccca 180
gtaaggttct ccaatactta tttattttat aaacgtggtt ggaggggagt ttgtatagat 240
ccctcacacg aggctattgc tttgtttaaa acacggcgcc cagcagatat tgccttggaa 300
atgggggtat ctgatcatga gtctgagctg acttatcata tgttcgatga gcctgctctc 360
aataccttca gtgaggaatt ggccaatcag cgtatacaaa acactgctta taaacgcgtc 420
ggtacccgca aggtgccagt aagacccttg actaaaattt tggatgaagt gctgctgccg 480
gatactgaaa ttgatttcat gagtatagat gttgaaggct ttgattacca agtgcttgcc 540
tctaacgact ggtcaaagta caggcctcgt atagttctgg cagaagcact tgatgatgtc 600
gctggcgaac gcatacgcag tttcatgatt caaaatcatt acaaagtcat agcgcgtaca 660
ttcaacactg agttttatca agatcttttg aaactgtaa 699
<210> 161
<211> 906
<212> DNA
<213> 糖原甲基菌
<400> 161
atgtccaatc tagcacctgt tgccctgttt acttataacc gccctgacca tactaaaagg 60
acgattgaag cactgaagaa taataccttg tctgctgaaa cggacttgct gattttttct 120
gatgctgcaa aaaatattac acagcaaagc atggtggatg ctgtcagagc gtttactcac 180
actgttgaag gcttcaagtc agtaagaatc atagaacgtc aaacgaattt tgggctagct 240
gcttcgatta ttgatggtgt aacaaatgta cttgcagagt atggtcgcat aatagttctt 300
gaagacgaca tggtcaccag tccatatttt cttcaataca tgaatgatag cttgagtcag 360
tatgctgatt ttcatgaagt tgcaagtatt catgcctatg tttatcccat cgcaggattg 420
cccgatactt tctttttgcg tggtgcagat tgctggggct gggctacatg gagggataga 480
tgggattggt ttgaaccaga tggaagtaag ttgtttgcgc aactgaagca gcttaacttg 540
ctgaataagt ttgattataa cggtagttat ccattttcaa atatgttgcg cgaccagatt 600
gcaggaacca ataattcttg ggcaatacgt tggcatgcta gtgctttctt gcttaataag 660
ttgacgcttt atcctggtaa agctttgctt agtaatattg gacatgatgg atccggtgtg 720
cattgtggag aaagcgaaac atactctgcg gagttgagag ctgaccgatt actattgact 780
gatattccat tgcgcgagtc tgagccggca tttaagaaat ttgagcaatt ttttcttgaa 840
agcaaaccat cagttgttcg caaaatgatg ctgaaggcaa aatccgtatt taaaaaattt 900
ttatga 906
<210> 162
<211> 816
<212> DNA
<213> 糖原甲基菌
<400> 162
atgagtttta tcaagatcct aaaattatta tgccccccac tttttctgca tattctgcag 60
aagtataggc ggcgtaactt tgcctcttcg ttcgccggaa attattcttc ttgggcgcat 120
gctaaacaaa atagtggtgg ctatgatgcg gaaaatattc tcaccatcat tcaagagtca 180
gctctcaaag tcaagcgtgg tgaagcggtt tttgaacgag attcagtatg tttccatcat 240
gttgagtata gatattccgc tttgtctgga ttgctatacg cagctgttag ttctggtggc 300
aagttgagtg tcctggattt tggaggctct ctggcaagtt tttattctca gcatgctgca 360
atattgtcta tagttaagga tttgcgttgg ggagttgttg agcagccaca ttttgttgcc 420
tggggtcgcg agcacctaac cacaactgat cttaaatttt acaatagcct cacagagttt 480
attttggatg gaaaacccaa tgttattttt ctttccagcg tcctgcaata tttggagcat 540
ccataccagc tgttagaaga attattgagg ctagattctg agtttattct tttcgatcgc 600
acggcttttt atgacgttgt tgaccgctta actgtccaga cagtgcctgc atcgatttat 660
ccggcaagtt accctgcctg gttcatttct tgggacaaat ttataaatac tatgagtgca 720
ggagggtatg aggtcatcat ggagtttcct tgtgcagacc tgacggacat aggctattac 780
aaagggcttt ttttcaagcg caagagtgta agttga 816
<210> 163
<211> 999
<212> DNA
<213> 糖原甲基菌
<400> 163
atgaatgatg aactgtactc aggtaagaat attcttgtta ctggtggctt gggttttatt 60
ggttcaaact tggtcaaaag attaattgcg cacaaagcca aggtgaccgt tgtagatagc 120
ctgttacctc tttatggtgg caatgccttt aaccttagtg gctatgaatc gctggtcaat 180
atcaacatca gcgatgtacg tgatagtcat gccatggctt atcttatcaa aggcaaggat 240
taccttttta accttgctgg acaaactagc catttggatt ccatgaccga ccccaggacg 300
gatctggata tcaatgccgc agcacaatta tccattctgg aagcatgccg acagcataat 360
cccgatgtca gaatagtctt cgctagcacc agacagcttt atggcaagcc tgagtattta 420
cctgtagatg agtcacaccc gattcagcca gtggatgtga atggcatcaa taaattggca 480
ggggagtggt atcacattct ctataacaat gtttacggta tcaaagcctg tgcgctacgt 540
ctgacaaata catatggtcc tggcatgcgc gtcaaggatg cccgtcagac ttttcttggg 600
atttggttgc gtagagtgat tgaaggcaag ccaattgcgg tatttggaga tggcttgcaa 660
ttgagggatt tcaattacgt tgatgatgtg gtggatgctc tgttactggc tgccgccaat 720
acagaagcag atgggcaaat atttaatctc ggcagtgatg aggttgtaaa tttacagcaa 780
gtagctgaat taatgacaca atttcagcct ggttccagct atgagattgt gccattccca 840
cctgagagaa aagccattga tatcggtgac tactatagtg atttcaataa aatcaagcag 900
gttttaggtt ggagcccccg tgtgggcttg caacaagggc ttgctgcaag cctggcatac 960
tatcgccagc atcatgataa atattgggac aacgtatga 999
<210> 164
<211> 1101
<212> DNA
<213> 糖原甲基菌
<400> 164
atgattttaa tgaatgactt caaggctgaa ccagaagctt tgattgcagc gcagctgcaa 60
gccgtcgagc gtgtgctgcg ctccggttgg tatgtattag gtgaggaggg gcgcaagttt 120
gagtcattgt ggtctcagcg ttgcggcact tctcatacag tgggtgttgg caatggcatg 180
gatgcgattg agataggatt gcgcgcgctg gacattgggc ccggtgatga ggtgattacc 240
actgcgatga cggcttttgc ctctgtgctg gcgatcatac gtgcaggtgc tacgccggtc 300
ttggccgata ttgatcctga cactggctta ttgagtcatg aaagtgtcaa gcgatgcatc 360
aactcgcgaa cgaaagcggt cttgctagtc catctatacg ggcaaatcag ggatatgcaa 420
tcctggctga acttgtgcga tcagcatcaa gtggctttgt tggaagattg tgctcaagca 480
catttggcgc aagcggaagg taaagtggcg gggagttttg gtcgctttgg tgcttacagc 540
ttttatccga ccaaaaacct gggcgccatt ggcgatggag gggctttggt aacatctcaa 600
tctgcgctgg cagacaaggc tgcagtgtta agaaattatg gccaaagtgt gcgttaccat 660
catccagagt ttggcttgaa tagtcgtctt gacgaaattc aggcggcctt gctcacggta 720
aggctagagt ggctggaaca atatacaagt cataggcaat caattgccgc tcaatacagg 780
cagcagttga ataatccata cgtgcgcctc atgcaaactc caacagagcc attagcccat 840
gtctatcatt tgtttgttgt gctaacggag caccgtgaag cattgcaggc tcacttgcag 900
gcaaatggcg ttcaggcatt gattcattat cctgtgccta ttcatcatca ggaaaagtgc 960
agcgatatat tgagagatcc ggctgggctg caatttagtg aggcccatgc acagcaatgc 1020
ctttcgctgc catgtcatcc tcaaatgtct gaacaagatg ttcagaccgt cattgctgca 1080
gtcaataggt ttgcactgta a 1101
<210> 165
<211> 942
<212> DNA
<213> 糖原甲基菌
<400> 165
atggagcatt ttgtcacact gtttgatagc aagtttctgc ctcaaggttt gtgcctgcat 60
gagtcgctgg cccgccatgc cagggatttt catttatgga tagtctgtat ggataaagtg 120
gtgcatgagc aactggaaaa attgcagttg cctcatgttt cgcttatgcg cttggccgat 180
tttgaaagcg aggcattatt ggccgttaaa ccaggcagaa caaaggggga gtattgctgg 240
accataaccc cattcactgc cgaatgggtg tttgctcaac acccagaggt ggcacgagtc 300
acttatcttg atgcagattt attttttttc aacgatcctg cgatactttt tcatgagttt 360
gaacaaagcg gcaagcatgt gatgattact gagcatgcat atgcacccga ttacattcag 420
catctggaaa cgagtggacg gttttgtgtg caattcatgg tatttgatcg aagtgaagca 480
tcccgtaaag ttatgcattg gtggcaagat cgctgcgtgg agtggtgttt tgcaaggatg 540
gaggatggaa agtttggtga tcagaaatat ttagatttat ggcctacaat ttttgccgat 600
gatgtccaca tattgaagtg cgttgaacaa acgttggcac cttggaatgt agactatcaa 660
cttcagcacc aaagtgggaa attcaagccg gttttttacc actttcatgc attccgcata 720
atcaagttta atcttgtcag actttatgaa gggtaccaga tagctaaaag ttctcgttac 780
ctctatgacg agtatcttgc gactttgcag aaaaaaattg ggatgttgca tcggtttgcc 840
attccgttgc cattgttgcc agaaaaatgt ggtattaggc caaaattggc ttcttattac 900
acatggatca gaggatttac cgctacagct aagatcaaat aa 942
<210> 166
<211> 768
<212> DNA
<213> 糖原甲基菌
<400> 166
atgcaaaaac ttagtgtgat tacggcaaca tataatgccg ctaaaaattt accagattta 60
gtgcaaagcc tgcttagtca aactgatatg gatttcgagt gggtcgttgc agatggcggt 120
tcaagtgacg aaactatatc ttatctaaaa agcgttgtag gcattaatct tttgctgtca 180
gcgcaacagg attttggtat atacgatgca ttaaatcgtg cgatttcgct aagctcaggc 240
gattattatt tggtcttggg tgccgatgat attttgtatc cacatgctgt cgaggcgttt 300
aagcgtgcgg ctggcatagg tctgcctgat ctcgtcaccg caagtgtaga gtcagatcat 360
ggtgtcatga ttgctggaag tggcaggcca tttttgcgcg gacaattggc ttatatttcc 420
aatcattctg tcggtactat gatcaaaaaa agtttgcatg atcgttttgg ttattactcc 480
cgccgattcc ctatcacggc agatcagtat tttatcaagc gtgtttgtgg cgctagcgaa 540
acggtgattt acaaagcaga ttttgtagca ggctattatc cagctacagg cgtgtcagga 600
gcagatgtcc ctgggacgat ggttgaattt ttccgcgtgc aattggaaac cgaacctaat 660
tcagtgctcc agctagtact tttcattttg cgtttgatac gccatacccc caagctcatc 720
cggtatgcac actacaaaaa attgcgcgat ctaccccagc atgaatag 768
<210> 167
<211> 1083
<212> DNA
<213> 糖原甲基菌
<400> 167
atgaatagca acgtattgtt tatcactggc tttcatcctg gaggtatggg ttttattggt 60
gcaggtgagg caatcagtca gcaacatata gagcgactga taaagcaagg aaggaaagtg 120
catgtgctgg cacttgcccc taattatcaa gtcgccagtc ctgaggttgt tgcaagctgt 180
gcttcctaca ccacgcttac gcatacgcga tggatgacgt ttgcagcttt atggcgctca 240
cgccagcagg gaagtctgct ctgcccctgg ttatttacgc gtgtatcacc gcaagctgaa 300
cgttttatcc gtcagttgtt ggaccaacac gccattactg agatctatct tgattttcca 360
tcttgtcttg gcttcgcgcc aacatacaat caattaccca ttcattacat tgttcatgat 420
gtgttgtcgc aaaaagttga gcgacgtcct ttattaaaat ggctgaaaaa tcaagtgttg 480
cgcacggaat cgtccctgct gcgtcatgtc acccagtgtt tcacactttc cctgaaggac 540
aagctgagat gcgaggaaat agggtatagc ggccagatag aggtgcaggt gccgcacatt 600
ctcaaggtag gggttgttaa tcaaggagtg ccaattgcag ggatcctcaa gcaatttcct 660
ggcaagaaaa acctggtttt ttttggcaac atgcagcggg ctgaaaatca ttactccatc 720
ttaagatttt tgttgtgcag ttatcctggc atctggttgg agcatcgcga tgttcagtgc 780
tggatattag gtttggcacc aagaacgcta ttgcgttgga tatcgaaagt gttgcctggt 840
gttagagtca ctggcgctgt tgatgaccca actgaggcgt ttaaggcggc aactttatgt 900
attgcacctg tatattacgg tgctggtgtg aaaatcaaag ttttacaaat gctggaatcg 960
ggagccacag ttatatcgac gccagtcgga gctgagggta ttcacggcag tgaaaaactc 1020
attacggtgg aaagtgctcg tctatcctcc actatcaagc aacgtttggc agttgaatca 1080
tga 1083
<210> 168
<211> 924
<212> DNA
<213> 糖原甲基菌
<400> 168
atgaatcagc atgaactccc cagcgttgca gtgttgttgg ccagtttcaa cggtagggct 60
tggatagcgg agcagcttgc cagtattctt gctcaacagg gtgtcaagct tcatgtgttt 120
attgcggacg acttatccac tgatggcact tgggagtggt tgaatgtaga ggctgcttgt 180
catcaaaacg tgactttgct gccacataat cagcgtgcag gttctgcggg caggaatttt 240
tatcgtttga tccacgaagt tgatctggat ggtttcgatt tcgttgcatt tgcagatcaa 300
gatgatgtgt gggatagcta taagttgagc aggcatgcac gcttgatgaa gctacatcag 360
gctgatggtg tgtcttccaa tgttgaggca ttttggcctg acggcagagt gatgctgatc 420
gttaaatctc aagctcagcg gcagtttgat tatctcttcg aatctgctgg gccaggttgt 480
actttcttga tgactactcg cctcgcacat caagtgcgca atgtgctcca agatgagcta 540
tctccagcgc gggatgttac tttgcatgat tggctaactt atgcaattgc acgttccttg 600
ggatatacct gggtgataga tgctaaccct tctctgaaat atcggcagca tggcaataat 660
gtgattgggg ccaatgtcag tcttaaagcg aaatggacga gattgaaaca aatccgcgat 720
ggctggtatc gccagcaagt cattaaggtg acacgcatcg cttatgcttt ttctcagcgc 780
gaagatttgc agcgcttatt ggttttgctg gagaagcctt cacttggaaa ccgcctgcag 840
ttattgccat atgcctggca tggaaggcga tcagtgaagg atcgtttatt cctgatgttt 900
agtattgtgt ttaagtggtt ttga 924
<210> 169
<211> 954
<212> DNA
<213> 糖原甲基菌
<400> 169
atgagtcagc aacatatttt ggttaccgga gctaatggct ttgtgggtcg atcactatgc 60
aatcaattat gccaatcagc ctttcaagtc acccaggttg gacgtgctct aaatagcgct 120
gatgggggag catatagcca ggttgtgtcg atagatggaa caacggattg gtcgaccatc 180
ttggatgagg ttgaggtagt gatacatctt gctgccagag ttcatgtgat gcaggaaaac 240
ttagttgatc caatcgtggc ttactggcaa accaatgtcg agggcacctt gaatttggcc 300
aggcaagcgc taaatgctgg ggttaaacgc tttatttttg taagttccat caaggttaat 360
ggcgagcaaa gtttcccagg caaaccattt actgcagaag atatgcctat gccagaagat 420
gcctatggca aatccaagtg ggaggcggag cagggcttgc ttgcattggc aaaggattca 480
aatatggttg tggtcattat tcgcccacct ctggtttatg gtcccggtgt aaaaggtaat 540
ttttccacca tgatcaaact gctgcagaca ggcttgccat tgcctttcgg ggcgattgcc 600
aatcaacggt ctttggttgc tatcgataat ttgatccact taattatggt gtgtattaat 660
catccggccg ccgccaatca ggttttctta gtcagtgatg gtgaggattt gtctactacc 720
gctttattgc gtcgcttggc tctagcggct ggcgtatcat ctagattgat tccctttcct 780
gcagcatggg tcaacttcgt ctttactgtt ctgggtaaga aaatgatggc agggagaatt 840
ttagggtctt tgcaggtgga tatcagcaag acacgcgagg tattaggctg gcagcctcct 900
gtgacagttg atcaagggct gcgaaattgt tttccaacta aggctgagcc gtga 954
<210> 170
<211> 552
<212> DNA
<213> 糖原甲基菌
<400> 170
gtgattcgtt tttttgacat tgtattttcc ttgcttggcc tggtattcgg tttgccatta 60
ttgataataa tttatctggt cggcttgctc gatacaggct ctcccttatt ccgccaagtg 120
agggtagggc ggcatcgcca gccatttacg ctggtgaaat tccgcaccat gaaagtcaac 180
acagcatcag ttgccagtca tctggcttct gccagctcta ttacttggtt aggtagtttt 240
ttacgcagta caaagttaga tgaattgccg cagctttgga atgtgctcaa gggcgagatg 300
agcttggtgg ggccgcggcc gaatttgttt aatcaggatg agttgattgc agcgcgtgat 360
gcacggggtg tttatgcagt tcgaccaggc atcaccggac tggctcaggt gaatgacatt 420
gatatgtcta tgccaaagtt gcttgcagag acagatgctt ctatgttgca gcaattaaat 480
ttaaagcttt atttcaagct gttaattcag actgtattgg gcaaggggcg tggtgacagg 540
gtcgtgcggt ga 552
<210> 171
<211> 1816
<212> DNA
<213> 糖原甲基菌
<400> 171
atgcttgcgt ggtgggtagc atttcttttc cgcttcaatt ttgatatccc tgccccattt 60
gccgagagca tgttgcaaag tgcagcttgg gttattcccc tgcaagcaac atttttcctg 120
ctatgcggcc tttaccgcgg tgtatggcgt tttgccagtc tgccggattt acagcggctg 180
attcgagcga ttggggtggc cgcagtagtt gtggtagcaa ttttgtttat gttccagcca 240
catggggttg tgccgcgctc ggtgttgatc atgaatccca tgctgctgct tttgttgatg 300
ggtggcagcc gcattgccta ccgcgcctgg aaagagcatc gactgtatgg cgcggcccaa 360
tcctcaggta agccagtgtt ggtgcttggc gccggggatg ccgcgattgc cttgctcaag 420
gatttatcca agagtcatga gtggcgcata gtgggcttgc ttgatgataa gcaatcaatg 480
ttcggccgtg agttgcttgg tgtaaaagtg ctaggcaaac tcagcgattt tcctgagatc 540
gccaaggcaa tgtctgttca gcatgtgatt gtggccattc cttcggcgcg caacaacgca 600
ggcgccagat tattgatatg gccagtcagc acaaactcaa ggtacttacc gtgccatcac 660
tggaagattt gatgagtggg cgtgtcagca tggcgcagct acgtccggtt gaggttgaag 720
atttgcttgg gcgtgagcct gtggtgttgg acgatgatgg tttgcaccag ttgatcgata 780
gtcaggtggt tatggtcact ggcgcgggcg gctcgattgg ttcagaactt tgccgacagt 840
tactcaagtt tcagccttca atgctggtgt gtttcgacca ttcggagttt tctctttata 900
gcctagagca agaactgacc gctttaaagc tggatgtgcg gattgaatat ctggtagggg 960
acgtcaagaa tgcacgacgc gtgcagcacg tgcttgctag ttatcagcca gcacagtatt 1020
tcatgctgca gcctataaac atgtgcctat gatggaaaac cgtaacgttg cagagtcatt 1080
atccaataat gtgctgggta ctttcacagt agccagtgca tgtaaggcgg cgggcgttaa 1140
taagtttgtg ctggtatcca cagataaagc ggttaaccca accaatgtca tgggggctag 1200
caaacgtctg gctgaaatgg tgtgtcaagg tttgcaggcg gaaacaggaa cccgctttgt 1260
ggtagtgcgt ttcggcaatg tgctgggcag cagtggtagt gtgatcccta agtttaaaga 1320
gcaaattgcg cttggtgggc cagtcaccgt tactcatccc gagatcacgc gttatttcat 1380
gtctatacct gaggcgtgcc agttggtcat gcaagccgga ttgatgggta agggcggaga 1440
aatattcgtg ctagatatgg gtgaccccat caagattgtg gacttggcgc gtgctatgat 1500
taggttgtca gggttggggg atgatgaggt cgacattgtt ttttccggcc tgcgccctgg 1560
cgagaagctg tacgaggaac ttttggcaga cgacgaactc actttaccga cgccgcacga 1620
taaattgcgt atcgccgtgg ctagaagtgc agatgaggcc tgggttgtgg ctttgctcaa 1680
gtgggtagac aagtcatcca gcatggatga ggcagtcgtg aagcaagagc tcaagatgtg 1740
ggtggaggag tatgcaggtg atatacatgc tagtctttct tctgcgttga ctcccgggtc 1800
atcgacaata cattaa 1816
<210> 172
<211> 876
<212> DNA
<213> 糖原甲基菌
<400> 172
atgacaaaaa aaattaccaa ggcagtcttc cccgtggcag gtcttggcac gcgtttcttg 60
ccggccacca aagccagccc caaagagatg ctgcctatcg ttgataaacc tctgattcag 120
tatgccgcgg aagaagcagt tgctgctggt gcaactgaac tgatctttat tattggtcgc 180
aataagcgct ccattcctga tcattttgac aagtcttttg aacttgaagc ttccctagaa 240
gccagcaaga aaaccaagat gcttgaggaa attcagaaca ttctacccaa gcacgtttcc 300
tgcatttata tccgtcaagc tgaagctttg ggcttgggcc acgcggtgtt gctggctaaa 360
tctgtcgtgg gtaatgaacc gttctctgtc attttggcag atgacttgat tgatgctgaa 420
aagcctgcga tgcaacaaat gactgagttg tttgaaaagc aaggagcttc aattcttggt 480
gttgaagatg ttgagccaag cgagacagca agctacggta ttgttgatgc agtggaattg 540
acaggcccag atgtattgca gctgaacggc attgttgaaa agccacagcc tgaagatgca 600
ccttctaacc tggcggtggt tggacgttat attttgactc ctgaaatctt cacctgcctt 660
gagaatgtca agccaggtaa gggtggggaa attcaattga ccgatggtat tgctgcgctg 720
atggagcaac aaaagattct ggcttatcgc ttcaagggta agcgttacga ctgcggcagc 780
aagttgggct atgtcaaagc caatgtcgag ttttcgctta agcatgaaga aattggtgag 840
gagttctcgc agtatctgcg tgaattgacc aagtaa 876
<210> 173
<211> 26858
<212> DNA
<213> 鞭毛甲基菌
<400> 173
tcagcctctc tgggcaaggt tttgctgcca atgccaacta tccttgcaca tctgctcgat 60
gccacgcgtc gctttccaac ccaatgcctg ctcggcataa gcaggatcgg tataactggc 120
cgccacatca cccggccggc gtgccaccag ctgataggga acagcctggc cactggcgtc 180
ttcaaatgcc ttgaccattt ccagcacgct atatccttgg cccgtgccaa gattgcatgt 240
gaacacacca gcttccttat ccagccgctc cagggcacgc aaatggccaa ccaccaggtc 300
gaccacatgg atgtagtcgc gcacgcccgt accatccacg gttggatagt cactgccaaa 360
cacagaaaga gattcacgct gcccctgggc tacctgggtg atgtatggca tgaggttatt 420
gggcatacca ttcgggttct caccaatgag gccgctctca tgcgcgccca caggattgaa 480
ataacgcagg atggcaatac gccactctgg atcggagact gccaagtcgc gcaggatatc 540
ctccaccatc agcttgcttg ccccataagg attggtcgca gacaacggga aatcctcgcg 600
aatcggcaca ctggctggat cgccatacac agtagcggac gaactgaaga ctaatcgttt 660
gacgtcatgc gcctgcatga cgcgcagcaa ggtaacacta cccgccacat tgttatcgta 720
ataacgcaaa ggctgcgcga ccgactcccc caccgccttg agcccggcaa aatgcatgac 780
tgcctggaat gggtacctag aaaataaatc actcagtagt gcttcatccc gcacatcccc 840
ttccaccaat acgggtgcct tgcccgtgat ctgcttgatg cggtcaacga tatgcgcctg 900
gctattgctg aaattatcca gcaccaccac ctcatagccc gcattaatca gttccacaca 960
tgcgtgggaa cctatgtagc ctgtaccgcc tgttactaat aacattaaaa acttttcctt 1020
tagtccaata gccctattga agcgccacac atatttatag tagctttata aacatagaaa 1080
acttttaaaa aaatctgaat tagaaagtta agctaccatt ctgtgatagc cttcttgtaa 1140
tataaaccag taaataataa tttcaccaca cccgcaaata atccagatat taagtgagtt 1200
aatagattga cgacattaaa taacactatc attgtcactg gtggcgcagg cttcatcggt 1260
ggcaacttcg tactcgactg ggtcaaggca ggactaggca ccgtcatcaa cctggacaaa 1320
ttgacctatg ccggaaatct tgaaaacctg gcagacattg aaggcaaccc caaccacatc 1380
ttcgtacatg gcgatattgg tgaccgcgcc ttggtcgcca agttgctggc agaacacaaa 1440
ccccgtgcag tcatcaactt tgccgccgaa agccatgttg accgttccat ccatggcccg 1500
gaagacttca ttcagaccaa tgtagtcggc accttccact tactggaaga agtacgcgcc 1560
tactggaata gcgtggtgaa aacccaccca gaggaaaaag aaaatcctca gttccgcttc 1620
ctgcacgtct ctacagatga ggtgtatggc acactgggcc ccaaggacca agcgtttacg 1680
gaaaccaccc cttacgcccc caatagtcca tactcggctt ccaaggcagc ctcggatcat 1740
ctagtgcgtg cctaccacca cacttatggc ttgccggtat tgaccaccaa ctgctccaat 1800
aactatgggc cttaccattt ccctgaaaaa ttgattccac tatgcctgct caatgcgctt 1860
gctggtaaac cattgcctat ttacggtgac ggccagcaaa tccgcgactg gctattcgtc 1920
aaggatcatt gcagcgccat ccgccgcgta ctggaagcag gccagctcgg ggaaacctac 1980
aatgtgggcg gttggaacga aaaggccaat ctcgatgtag tacagacctt atgcagcatc 2040
ctggatgaac tcagccccaa ggcagatggc tcaagctaca aagaccaaat cacattcgtc 2100
aaggaccgtc caggccatga ccggcgctac gcaatcgatg caagcaaact ggagcgcgag 2160
ttgggctgga agcctgcgga aaccttcgag tcaggcatca gaaaaaccgt ggaatggtat 2220
ctgcaaaacc aggcatgggt gcacaacgtc accagtggag aataccgcaa ctgggtcagc 2280
aagcaatata gcgggagcgc agcatgagaa aaggcatcat cctcgccggt ggatcgggca 2340
cccggcttta ccctgtcacc caggcagtct ccaagcaact gctgcccgtg tatgacaagc 2400
ccatgatcta ctatcccttg tccacgctca tgctggctgg gatacgcgac atcctcctga 2460
tctcaactcc gcaggacaca ccacgctttg aacagctatt gggtgatggc agtcaatggg 2520
gactcaatat tgcctatgca gtacagccct ccccagatgg attggcccaa gcctttatca 2580
tcggcaagaa atttattggc aatgatccaa gtgccctggt gcttggcgac aacatcttct 2640
atggtcatga cctggcacat gacctggcac atgccgatca acggcagcat ggcgccactg 2700
tatttgccta ccctgttcac gaccctgaac gttatggcgt ggtcgagttc aacgatgctg 2760
gccaggctat cagcctggaa gaaaagccca aagagccaaa atcccgctat gccgttactg 2820
gactgtattt ctatgacaac caggtcgttg acattgccgc cagcctcaaa ccatctcctc 2880
gaggcgaact tgaaattacc gatgtcaaca aaatttacct ggaaaggcgc tccctcaatg 2940
tggaattgat ggggcgcggt catgcctggt tggatacagg aacgcatgaa tccctgctag 3000
aagcctcact attcatcgaa accatagaaa agcgacaagg cctgaaagtc gcctgccccg 3060
aagaaatcgc ttaccgcaaa ggttacatcg atgcagaaca agtagaaaaa attgcccagc 3120
catacctcaa gaatggttac ggccaatatt tgatccggat gctgaaagaa aaggtctttt 3180
aatgaatgtc acgcccaccc atattcctga tgtgatcgta ttcgaaccca agatattcgg 3240
tgatgcccgg ggattctttt ttgaaagctt caatcagaaa gcctttgagg aagccgtcgg 3300
caggaaatat gattttgtac aagacaacca ctcaaaatcc tcaaaaggag tattgagagg 3360
gctacattat cagatccagc aagcccaagg aaaattggtt agagtagtag caggtgaagt 3420
ttttgacgtt gccgtggata tccgcaaatc ttctccaacc tttggtcaat gggtagggca 3480
acatctgtca gcagaaaaca agaaacaaat gtgggtacca ccaggttttg cccacggctt 3540
cctcgtgctg tccgaaactg cagagtttct ctataagacc acagacttct acgcgcctgc 3600
gcatgaacgt tgcctaagct ggaacgatcc cgttgttggt attgaatggc cagatattgg 3660
cacgcccccg ctcctctcaa gtaaagatca acaaggctta ggcctccacc agacagagtt 3720
attcgcataa tggcaacttt caacaagatc ctgcttaccg gcatcaacgg ccaggtaggc 3780
catgctctct atccgaaact acaaagcttg ggagaagtcg ttgcacttga ccgcagccaa 3840
cttgacctat ccaaacctga ccatatccgg gacgtagtgc gacagaccaa accagacctc 3900
ataatcaacc ctgcagctta tactgctgtg gataaagcgg aatctgagcc ggagctggcc 3960
tacgccatca atggcactgc tcccggcatt ctggctgaag aagcagcaaa gctaaatgca 4020
ttgcttgtgc attattctac ggattatgta tttgatggca ccaaaactac cccttacaca 4080
gaattggatg aaacaaatcc acttagcgtt tatggagcca gcaagttagc aggagaaaaa 4140
gccattcaag aagtcggagc aaatcatcta atcttcagga ccagctgggt ttatggtgca 4200
tatggaaaaa atttcatgcg caccatattg agattagctg ccgagcgtga ctcattgaat 4260
atagtcgcag accagtttgg cgcaccaact tctaccgaaa gcattgcaga tgcaactatt 4320
actgcgctgc acgcatggga tgggactcaa agaggtgtct atcacttagt caatactggg 4380
gagacgagct ggcatggctt tgcactggaa atcattcgcc agtatggaga aatagcccaa 4440
aagaaaaatt tagcgaaatt aaaatccact gtagaaaatg ttgtcggtat tacaactgca 4500
gaatacccca caccagctca tcgccccgcc aactccaaga tgagcactga aaaattcatg 4560
agcactttca aaactgaatt agcaccatgg gaattggctt tgcgatctac agtaacccac 4620
ttagcaacat tctcggtcga aaatcattag cattattact aattaatcat taaaactgac 4680
ttcagtcaga ccaagggaaa ttattcatga acgtccatat tgatcattga agcgaacaat 4740
atcatcttca cccaaataag ccccagactg aacctctatc atttctaaag gaagctttcc 4800
tggattagcc agcatatgcg tcacacctaa aggaatataa gtagactggt tttcagaaac 4860
aaggaactcc tcatctcctc ttgttacctt cgctgtaccg gtcaccacaa tccagtgctc 4920
ggctctatgg tgatgcattt gaagagataa cgtagcacct ggattcacta caatacgttt 4980
tacttggaac cgtgccccca tatcaatact gtcataccag ccccaggggc ggtgaacctt 5040
gcggtgagtc ttggcctcgg gccttttctg gaccttaagc tgctccacga tttttttcac 5100
atcctgagtt ttacttttat ctataactag caccgcatct gctgtctcaa tcaccgcgat 5160
gttttgcaga cccacacatg caagcagcct acctgaagac acagctagag tattcgagca 5220
atcattgaac agcacatctc ctaaatggga gttacccgcg ttatcctgcg gcaaaatttt 5280
cccgaatgaa tcccaggccc caacatctga ccagccggca ttcaggggga tgactatgcc 5340
tgcaggcaga ttatcggcac cacgagcgac atgctccatc accgcatagt ctatagaatc 5400
gctaggtacc tgttgaaatt taagcttgtc cacccgaaca aaatcgccat cgcgttgttg 5460
accatcccaa gcctgcttac atgaagataa gatatctgga cgagtcttag caatcgcatt 5520
cagccatacc gtggcacgca tcatgaacag accgctgttc cagaaataat tcccacttac 5580
tacatattgc tgagcagtag cctcatcagg cttctcaaca aactgctcaa tactgaaagc 5640
agaaccgaaa ccttccagca ctgcgcctga cttgatataa ccatagccag tttctgccct 5700
atcgggcacg ataccgaagg tgacgatctt accagcagcg gcatgttcag cccctgtcct 5760
cacggtatcc tgaaagtctt gcacattgat aatagcgtga tcggcgggca tgacaagtaa 5820
gattggatcc tggccgtggc tggcagcctc taaggcagcc aaggtgagcg caggggcagt 5880
gttcttgcct acaggctcaa ggagaataga tccacgcctt cccatcatcc gcaattgctc 5940
agcgataaca aagcgatatt cttcattaca taccagaatt ggagaacact cggttccaat 6000
gagtggatcg accctgcgta atgtcgactg aagtaaagaa tcattatcaa gcaatgtcag 6060
caattgcttg ggatagtttt ctcgagaaag aggccacaac cttgtgccag agccacctga 6120
taaaatcacg gcttgaatct gcataatttt ctcactggat agaaatataa agggaaagaa 6180
ataggcacag tatctaatta cttatttggc aaaaaccttg tcagcaaggc ctcatattgc 6240
tgcaacactg agtcccaggt aaataaggta tcgtattgag ccaagctacc ggctctcatc 6300
tcacgtaacc gaacttcatc attaagaagc tcatcaagag tgatttcgca gtccttttca 6360
ccagaaaagt aggccgcctt atctccagcg acccagcggt taaaacggtt atcgtgcgcc 6420
aatactgcat taccagcccc tagtgcctcc accaaagaag gattggtgcc gccaacttgg 6480
tggccgtgaa tatataatct tgagaaatac cgtaaagatt cgaccacgtg tttatcataa 6540
attgcgccag gaaaaagcac ctcgtctgag ccggcagctt taaccgcgac ctgataagca 6600
tggtcagggt tatattttcc tagcactaca agcctcatgc ctcgaggttt agcggaccag 6660
gctttcacca cctctaaaat agaattttca ggctctgcac gagcaattaa gatcgcataa 6720
ctgaaaggct taagtccata ttcctccaaa acggcctgat tcgcctcaat cactttatct 6780
gcgccgtatg gaatcattgt gatcttgcta ggcctgactc ttgtttccag atgacgcgca 6840
atttgcggat gatcagcaat cagatgattg cctaaaattg aaccagccca atcattaatc 6900
cagaaccaga gtttagcaac tgccccccat tttttccgat gccactcgat tccatccata 6960
ttaattagat tagttattcc tttagttcta tagagcccac agaataaagc agtgttatac 7020
ccaagagtta aaataagatg ataagtattt gaagcatgaa tcgttgactt ccaatcaaaa 7080
agaatagtgc ctaaagaacc ctggatagat atcggaatat ttactcgctt tataccattc 7140
cacatatcct catacatagg cccattacca tctacttggc aataaactgt tactttccac 7200
ccttttcttt caagataaat agccaaatgc tctgcaaatg tttcaaagcc accatgcgca 7260
gccggaattc ctctggttcc taatattgct attttcttat gcatacaaat acaaactcat 7320
gttaaatgtg attctaatat ttcttatttt tattaaaatt tttcatcaaa agctgaagta 7380
caggaacatt gttttgacgt tcgacaatag catcattctt gaatatacta tctggcattt 7440
ccgcatccca tccgctatat tctctatagc tatgatatgt ccatgaccat ttctcttgct 7500
caaagcgctc aactacatct gtcaagtaac gtaacctcga accagacgga gcccaccgaa 7560
taatgctaaa ttcaccgata taaagaggaa cattatattt attagcccaa ttacgagcaa 7620
tgtctagtcg attatttagg tattctttat cccacttttc actgggatat atatatgcat 7680
gtgggtatgc cgccaatcct tgatgagtaa gttcttgggg agaataaaaa tgaaagctgt 7740
aaactatatt attaaatgga acaggagtaa actgctccaa actagaagcc agcccccaag 7800
gactaggttc cagaaaaatt atatgatttt catctacttt acgtatggca gtaatcaatt 7860
cagtagcata cttttcccat actgatccag gcctaacaac aggctcatta atcaggtcaa 7920
accctgccac cacagtctca tttttgtatc ttttagcaat agttacccag ttattcttaa 7980
tgctttctcg taattgttga ttattccagt agatcgcctg atctccagca ggtttaggat 8040
caaaagcaaa aattacataa aatcccaact tacgacctgc ctccacaaga aaatccattt 8100
gcgacaactc aactggagaa atttcataat cattacattt tttacatttt tccaaatgaa 8160
taacgcttcg aattaaattg acgttaaact tttcaagatc ttccatgtca gcagaactta 8220
atttccgccc aagaacatta aaccctcgat aagaattttc tttaaaatcg tctgaattaa 8280
gaaaagcttt cggtccttgc aaagccgcag aaaccttatc gaccgaagca gctgtagttg 8340
tttcagaaga agagccacca gcagaagaag agccaccagc agaagaagag ccaccagcag 8400
aagaagagcc accagcagaa gaagagccac cagcagaaga agagccacca gcagaagaag 8460
agccaccagc agaagaagag ccaccagcag aagaagagcc accagcagca gaaggattgc 8520
ttgaattgat agatttatta gatgttgaat gctttatagt tacattagaa tcactactag 8580
actcatcaat aggagcttct gtaacattag cagcagaaat agaattactt ctggatttat 8640
tagctgcagc ctcagattta acattcttct tataatcaga aggaaaaacc tttatctttt 8700
gtgaattagc ttgaggggta tcagaataag tggtactccc gtctacatct gtagatttat 8760
aaacttcagc aataccaacc aaaggcataa gggaaaacaa actaagtaaa acaatccttc 8820
gagagttaat taattgcata gttatggacc tccaggctag atacgatcaa atcacgccac 8880
ttcaaaaaaa cactgtaaat aaaaatccac acctattatt aacggcaaaa taatctaatt 8940
atttagctaa ttttattatt agctttaaaa tttatttttt acaattgaca cctataaaaa 9000
ttaatatata aagattactc ccgaagttaa attaaaaaac tcatacctta ttaaagtcaa 9060
agataatcac tatcaagcta tagcaatgga aaataatcca aataaatata acatacaaaa 9120
gagcctattt actgacatca caattcagaa gatgaaaaaa tcaagaatcc taaccccatt 9180
aagaatttta ctaaacatca ccgcaaaata tttttagatc aaacccgttt accataatct 9240
tagcaaatac acattacgat atacttttct gataaacact gatagttttt atcgcaatct 9300
catcccaact gaagcgagtt ctcatatcgt tttctgcttg caaagtaatc ctagataagt 9360
catggtaaga aaaaattttt acaagctttt cagcaagatc aatataattt ccagcagaaa 9420
acaaaaatcc gttttcccca tcatttataa tttgcgccat acccggaagg tctgaagcta 9480
acactggagt tccataactc attgccatta ataaaacacc actttgatat atttttctat 9540
aaggcagaac aatcaagtct gccgcactat aaaacattga tatctcttga tctggtatgt 9600
atctaatatc caatttacaa aaatcattta gcccgttttt acttattaat tcttgatact 9660
tagagaaatt atctttccac acttttccag caatgactag cttaaatggt tttagtttat 9720
ctttaaccaa acctaacgct tcaatcaaca aatccaaacc ttttacttct ttgatttgac 9780
caaaaaataa aattaccttt tcatctgatg atacattaag agcttgacga gcatctgctt 9840
ttggcatcga gggtgcaacc agaccaatat aacttccgtg aggaattaca tgtattttat 9900
ttatagaaac attacttcta ttaatcaact catccttact aacttgattg tgcacaatta 9960
attgattaca gagaaagtaa gtccatttta acaagataga gaaggttaga cccggcttaa 10020
aagactcaac atcgtgcact gtagcaacaa ccttaaatcc aaataagcga aaaaataata 10080
cacttaaaaa ttctaaaaca cccacatgaa aaaaatgaaa atgggcaata tttgaataat 10140
tttttttagc atgctttatg ctcctacaaa gccctaagat atacctagcc cctcttctcc 10200
acgtagcatc ctttccccaa atatttacaa aagtaagttg catgaaaata ggtctattac 10260
cacaaggttt agaaatgtca caggtatacc aagttgcaga tactccctga tgtaacaaac 10320
cggcacacag tccagaatca taatagtcca taccaccgtg actaccaact ggctccacaa 10380
aggcgacgtt aatttctttc acataacacc caatctgaat aattattttt tacctgatac 10440
atatgtgtat ttaacaaaat ctttaatgcc caaaaataaa gcattatatg catcaagtct 10500
cttatatctg acccattcaa aagagtttcg aaacacccat aacataaaac ctattaaaaa 10560
tagacctttc ttaagcacag ttccatgagt aaaaacagtt aaaaatctat ttttcgcagt 10620
ttgataaaca aaaaaaggaa gcttaggatt ccttccttta aacataccaa cagcctctac 10680
ctctttgccc tggctaccct gagccagatg gcgaacaaca gcttttggca tataataaat 10740
tttatatcca taagaaatta ctcttaaaga taattcgacg tcttcttcgt acataaaata 10800
gcgtggatcg aacccgccac actcttctaa aactgaacgt ctaatcataa aagcgcaacc 10860
actggcaaac tctacaaatc gatcttctag agctattttt gatacagcac ttaatccaca 10920
acctggtacg cgtgccgaac cagttaacca gttcatatac cccccaccat accaaagtat 10980
atccaaccca tcacccatca tagtaattct tggggtaacc aatccaactt cagggctaaa 11040
aaatccatca tgcagtaatt gtaataatcc aggttcaact agtgtgtctg gattaagaaa 11100
aaatatatat tcacaatctg tattaactat aacccaatct tttccaatat tgcatccctc 11160
accaaagcca agattttttt cacttttaat aagtacaaca tctggaaact cttctacgat 11220
gcactcagga caatcatccg gagatgcatt atccacaaca ataatctttg aatatctctc 11280
ttccctaaga gagtaaatac aagaaataat ttggtcacta gtattataat taacaaaaac 11340
tattgcaaca cttaagtcta actttttttt tgaactaaaa tccgtcatca ataagcacca 11400
ataaaaattg caaccatgaa taaagaatcg ttaacatatt tttaaatccg ttttgaagaa 11460
acaaaactcc ataatacttt aaagaactct ggtattgttt tataaatagc aaagaacggg 11520
cttatatacc acgggagaaa tttaaacgca tattttgccc aaacaaattg aaaaaaacga 11580
atcaatcgca tttttctaga acttgaaaac tgcgttctaa atgttcgata atttaaacat 11640
gcttgcttga taaatattac tgggcccaat ttagcagctt gcaggaatag ttgtatgtca 11700
tataaccctg gattattttt aacgaaagaa gacctcaaaa ccacacaccc ttgctttaaa 11760
gggtatactg gtaaaataaa gattccgaat aaagtaaata gtgatgacag tacgcaatca 11820
tctgatacaa aaggaaaacg tgattcttta taaatcctcc cagactcatc catatatgcc 11880
acagcaccaa atgcagccaa agcattggga tttgattcca gtaagtcaag ccgctttgac 11940
aaagatccca atggaatagt gtcatcgtga tctaaaatta gcaaatattt accggtcgcc 12000
aattcaatac cagttctata tgagtcttca ataccagcat taatactttt aaaatgcaat 12060
tttatatttg gatgatcaat ttcttgtaaa tatttccgcg ttccatcagt ggatccatca 12120
tcaacgataa tccactcaaa gtcttcaaca tctccttcaa ggacactttt tttagtatcc 12180
tcaaaatatt tcattgaatt atatgttgcc gtaataatac taattaatgg agatgtttta 12240
acattcatct ttaagttctc atattatttt atataattat gactatatat atattccaat 12300
ttacacttta agaagttagc tttccttttg taagattttt ttgattaaga taattagccg 12360
cgcacataag accagcaaga gtagccaaaa aagcaattcc cggggtttgc attaattctg 12420
gctgagtaat gcaggccaaa aaatactcta tcattgcagc aaaagaagct atggcaacac 12480
ttgatataaa taaatcatta gaccgcgttt gaatgtaagt taaatgaagt attttgaata 12540
taagaaaaat gactgacatg aatacaataa tgcctgtttt taaggttaaa tagatataag 12600
cactatgaac atatctcact tgctctgctg tcacatcaga tttagcaggc ggcctataag 12660
gggcaccaag cccaatgcct aataaaggtg accgctgaat tgccgcccat gccattttat 12720
tttcataaaa cctccagccg agagaagatc catgagaaac ctcctcctcc acactaaaca 12780
atctctgcat cgcgccttca atagcgcccg gcttaatagc tagcatagca cttaaaccaa 12840
atacagcaac aattgcaatt agtcctacac ttctaagcat tttttttgtc cctagcttcc 12900
agcataagaa caaaacagct aagaaagtcc ccccccaaac agcacgacca taggttaaga 12960
aaattccagc gcctgtaaat atacacaata taataagagt ctttgaaaaa cctattcggt 13020
tagcaaacaa agccagtaca aacaaaaatc cccaaacaat aatgtgagtt cctgacgtca 13080
tgcttcgtgt aacatcacta ttaatgcttc ccaaagtttc aaggctagta agctcgcgcc 13140
cgaacacatt tacacctaga aaaccttgca aaatctggcc aattgaaaat aaaaaagcta 13200
caaaaagaaa gccaaaaaca ataaatttaa atctttgtct atctgagcat gttaaagcta 13260
ttaagggaat caatagccaa taaaggaaat gccttgactc ccctaaaata tctttcaatg 13320
gcaatctaat ttcaaacacc gcccgaaata cagaaaaaag caacagtaaa agtacaacaa 13380
ataaaggaat agccaaaggt gacaatgctt gctttgtaaa gctaaattct gaattgtatt 13440
taaaaaaaca aaaaatgaat gttgcaaaca aggccatatc tgaagatggt attgtgcctc 13500
ccagcagtct tattgaaggc aaaaatgtat ctggaattaa tctagaagaa attgctataa 13560
cagctattaa agctactaaa ggatatgtaa aaccaataaa aataaataat atagaaagaa 13620
taatggctac tatccaccac catggaaaaa tagcactgac aaaaccaaat atcaaagcca 13680
ctattgcagc cattattaca aaaaatatac tccctatctt taaactaacg aaattagcat 13740
ccctacggtt aaaagataag agagaagaat tgttcttcat aatgacgcat tagccttgtg 13800
aaattttaat ggtaccttct acctaatatt taatatatat taaatataac tcaagacttc 13860
acctaaaggt tttcggtatg attgcggaac aacaaatgat tcccttaaat atccagcggc 13920
aacaaacatg ataattaatt cgttttctgg tatacgaagg tgattcctca tttctatatc 13980
ttgtttccta gttttactcc agttaagagc gcaacttcct aggccttgca aatgtaagcc 14040
atatataaaa ctcattgcaa acattccccc atcaatccaa ccttgataac gttccgcccc 14100
attaaaattt gacaaatcca ctgttataca aaataaagcc tgaacctctt cataaaaccc 14160
tcgtgcgccc ccttgaattt gtaaagtact cctaattaat tctggattaa gaattgcccg 14220
gacctttcca gactgtcgat tacaaactgc tggacttttt tgagcaatac gtacggcctt 14280
ttcaattaca ctatgctcta taggatcttt agtgaactgc cttacactat ggcgcataag 14340
aaaaaaatct tctttaaccc cagatattgc gtctaaaacc tcagctttag agcgcaaaat 14400
aaccccgcca tcattaatcc ttaataaagt gctctgatta tttttcttta accgatcaac 14460
gattacttct aattgagaat ctggctgacc aagacttcta ttaaattgac aataacgcgc 14520
cagtacattt atcggaacat ctagctgtgg atcaggccca aaattaagat gaaaattatc 14580
gactgatcca actaattgtc caatcactac ccttccaaat aacggcctgg gattaggtaa 14640
agacattcct ttctcgatgt tgtgataagt agcagtaata accgcaagaa tcttttcacg 14700
atctttctcg aaagaaatta cagatgacca tttaatatat cgtttagcat cgtaacaaaa 14760
gtctctcaat aaactcgggc ctcgaagaca aaatctcaga agccatttaa tagaaagcgg 14820
caagaaacca attatgtatt ttttcatctt acaactatac attctctaaa atatgtgttc 14880
aacttagtaa atttgacttt taacttataa aacaatcttt ttatttgaaa ttctagttaa 14940
taattctgct atgtactgct cataacgcaa tagttttttt tctgcaattt tattaccttc 15000
ttctactgca aacttcaact gctcccgact gttaaaacaa tccataacca aaccaactat 15060
ttgctcgtta gtattaacct tacaatcccc aagataagga taatccaagg cagaaaaaag 15120
cccattaaac ttcctactat acgctaatgg cacaacaggc actccacttg aaaatgctgc 15180
gatacaagca tgcatgcgag ctccaagaaa aaaatccatc cctgaaataa aagatttagc 15240
ttggctagga gaagaaaaag atggtgcaag cttagcagct ggataaagct cttgtaattg 15300
aacacacacg ttcacatcgt cttctatagg aaatgaggtc gttagcacat gaggaacaag 15360
ccatacttca caaccttcta ttcgagtaaa ctgatctaat agtgatctag taagttcagg 15420
ataattaaca ctaagaccga attgattctt cccagtatac ccaccgttat aaagtaatcc 15480
tgatacattt agtccaattt ttactttact tgaatcccgg gaagggcgtt gaaatggcaa 15540
tctaaaagca acgtcaatta cctcctctgc atttacagat aaattattct tttgcaagta 15600
tccaaatgac aatccatccc ttacaaatat tttagtgcac cgctgcatta cattattggc 15660
cacctttaaa ttaaacctac tttcgaatgg ccctatagtt tgcgggctta aaataagagg 15720
tttacgttga aacaagacaa ccaacttaga cacaatctgt attaggaatc gtgaaaaacc 15780
ataaatatca gcaaaactat caccttcacc tatatcaaac accacatcgc attcccggat 15840
tttcttggga taatcagaag ccccgatcaa aattcttttg agtgatacat ttgtccctcg 15900
ctcaattaaa gggttgccct caaagtaatc tttgtttcca ttagtgccga aaattcgata 15960
ttcaacctca acccccgcct gcaccgcagc tttattaata atagaaattt gtgcttcagt 16020
taaagcgcca acaccaagat tatctgaagt agtagaatgc caaagtaagc ctattttcaa 16080
catgactaat ataccaaaag aaaaatggaa agactaaata ctattacagt caaagtaaaa 16140
ttaactcccc caaacccagt aggtattttt ctaagccgta atgcactgaa aaatatcaaa 16200
aacaaggtta ataatgtgat gattaaagca atgaccatac cttttagtcc aatcactttc 16260
atcagaagtg gtgctgaaat tagcaaaata ataagtgcaa aaatttgtgc ccagacacgt 16320
attgtctgag atccagaagc agtcaataga acaccttgag gcgcagcaag atatcttgta 16380
aaaactaaca aaccaatata gggccaaatt gaatttaact ctacatattc atcaccaaaa 16440
acaaattcgg taatatgcat accggcaaac cagaaaatag cccagcacac agtaccaaca 16500
gcaagcatct gaagattaag ttttttagct agctcaacaa actctctagt attagtgtgc 16560
ttggcagcaa ttacaggtaa aaatacattt ccgagtacag gtgcaaattg cattgcacca 16620
tttagaaatc tcatacctgc ttggtaaata ccaactccag tggctcccag ataatatttc 16680
acaagcatgg tgtcaacttg gtagaaaaag ttagtgaaac ccgcatcaac ggcatatgga 16740
aatcctgctt ttaatgcttt tagaacagca actggagagg ctgacagagt atttaaatca 16800
ccaaccactc gcttatatgc ccgccacgac aaaataaaat aaacaaaacg agataaaaca 16860
aaacctaaac taattaataa taactcagcc ccattaatta ccattaaaac tattaagccg 16920
aaatgcaaca aagagccaat tgttgcaact tttgtttctt catgaaattt tccgatacct 16980
ctgaatgcaa tattaaaaaa atccccaaaa gaagtgagca aacaagataa cagtaaaatc 17040
caaaatattg ctctatctaa gtcatttgta tagaataagt aatgtccagc aaggcaacag 17100
acccccatca ctactgtgag atatagtttt gcaagaaaaa ccctccccat taactgatta 17160
atattatcag ggtatcttcc tatatctctt aacaactgat ttgaaaatcc atattccact 17220
aaaagcacag ctattgacgc aagagtaaaa ttgtacatca atatgccaaa gtctctcgga 17280
ccaaggaatc ttgcaagaat aatgaaaagt acaaccgctg atagcaaccg tgaaaaagtc 17340
gaaagagcca taaatgcggt atgtttaatc ataaattgct acatttttat tattaaagtt 17400
aggttaaaaa aacattgaat tttatgaaaa tgtacctata agtttttttc tacttttact 17460
atctacattt ttcagtaaag atttaacaaa ttcttcttgc agtgtaaaag cagagatatt 17520
atctctgcta atacttgaaa ctctaaaaag cagtccatca ggaatatatc cctgcaaacc 17580
taattcaaac ctttttatag tttgacccaa tccaccataa actgtagttt caccaacacg 17640
catccaataa agtattggct catatcgtgc cccatgctgg gctaataaat gtctaacttt 17700
aatttcatat ccatcaaaat ttaaaatggc attacccaac aaatcaacat taaatccttg 17760
agctgtatag caggtttcag gcttatgtgc ttgcaagccg cgactttggt ctcccccata 17820
agcaatcgaa agcattattc gcattccttg cttattaata taggtccgag aaagagtttg 17880
atcataaact ttattgaggt tttgctgcac ctcagggctc acttgtatag gagtaatcgt 17940
aggatcgatt ttccactcat cgaactcctt aggaatcatt gcttctaaat ttatatcttc 18000
tgctgcatta acaaacttag taggtttaag aattactcct cctaaagtag ctaccaataa 18060
cagtaaaaat ataattaaat ttcgcagtgt aaatccatcc attagacagg ccttattaag 18120
agtttaggct tttaactgcc attttttaac caaatattgt aggagcgtat caacactaat 18180
tatcaaaatt agagccacta caaaaagtaa cattccagca aaaccatgaa caaaaccctg 18240
accagcagca tctccaaaat gataagtaac taaagttaat accataactc taatcacatt 18300
agcggtaaaa gaaattggaa taatcaatat cccaagaatt acattacgaa taaatgaatc 18360
gtgctttaca acatttaaat aaagtaaacc cagcgcctcc aaagatatta aagtgtgcaa 18420
accagcacat gcatccgcaa caagtaattg atattgtccg atttggagga tcaccccact 18480
tcttgaaatc ggatatccta tccaataaag tatattttct gctacatatg agaccgcaat 18540
cttcattggt aatgtcacag catcaagaaa aactccagga agaggcacca taaaaatcaa 18600
gaagaataac ggaaaccaca atgctcgaag cccagaataa ccacggaaaa ttagcaacaa 18660
tccagcaaaa acaggaattt gagatgcaat atctaacggt gcaatatctt gagaacggcc 18720
aagaatgtag agtaaaagac caaaaactaa aactatcccg ccaattactg gcctgcctat 18780
aatattattt tcggccttaa acaattggtg tctctgtacc catactaaat acaagacaac 18840
gccaacaatt aatggtccat gagcttgatc ttcagattgc catacagtat ttaataagtt 18900
caaatatgta ggcgtataca taatgaacaa acctaataat agcatccaat tccgattgat 18960
tacctcccag ataccaggat tatcttgctc gattacctcg acagtgttca tatctacaaa 19020
tcaaccaata ttgacccaat taccttagta ccattattct tgcattgttc tacagcaata 19080
gataaatcat tcactcgagt atgattttgt cttgcaacta atacaattcc tccaacagta 19140
aaagcaattg cataaccatc tgaataatta ctaagttcgg gagtatccaa taaaattaca 19200
tcataaacac aagccaactc tttaattaaa tttccgaatg ttggcttgct aacaagctct 19260
tgaggattag gaggtaatgt accggcagtt aatacagata agttttcaaa aaaatttatt 19320
tttgaaatta catcataccc cgctcttcct gctaagatat cagataaccc acgtttgtta 19380
ctcagattgt atatctcatg ctggcgtggg tagcgtaaat tagcgtcaat caataatgta 19440
ttttcaccca attgcgcaaa aacaactgca agatttgcaa caaaagagct tgcattatcg 19500
ctgctgctta ctgaagaaac agctagtgct tttcgttccg gtgaaaacca atgcagcatt 19560
aattgactgc gtactgctct caaaacctca gctttgttac taaaaggctg atatgcagca 19620
acgagctcat taagatatga gttttggtca ggtgataaat aaggatagtt aaattgcctc 19680
gataaaacct gttgaatatc atcttcagtt atcaacccta atgcttgagc agcttctcca 19740
aagcgcaaac ccttctcttt atgtaaccgc ataattcttt cagcatcttc gggtgtaatt 19800
ttccccatcc gcaataataa actaccaatt gtaaattctg aaaattcgtt taccaatggt 19860
gcattttcta ctttttcaga gtttgaatta gaaggtgtaa atgaaatcat aattcagcct 19920
tccctaaagt tatcaggttt gaagtatttt taaaaaatct cagttttctt ttttctttac 19980
taatagtccc aagaagtggg gcttgtaata cttcaattaa gtcatcagca gtccgtactc 20040
ttcgatcaac aaactcagct aaaactccaa accctattcc taaaaacata cccaagagga 20100
ttgacaatat aatattcagc aataaatttg ggctagtggg agtaagaggt gccacggcag 20160
gattcaataa agaaatatca gattgatttg actgaccttc aatattcgtt tgagtatacc 20220
tttgcatagc catgtcgtat gctttttgag cattttcaac ctctcttgtc aaaacagata 20280
aaatatccct atctcgatta agttgtaata ctttttcttt ttgattattt aaagccaaac 20340
gtatttccgc ttcacgttgt tgcagaattc ttgaattact tgccacatta cttgaaaccg 20400
atttgatctg tctatctagc tcagacttaa gattttcaat ttctgcttta gctcctagat 20460
aaaaaggatg gtttctttca aatttctgcg aaacatctgc aaaccttgat tctgctctag 20520
caatttcagt tttaagattt tggataattg gattagctgc tacatcagga gactcataag 20580
cttcttttcc acttgaattt ttttcccgag atctcgcttc cataacttgt gcttgtgcaa 20640
taaccaattg agatgaaagc tcatttaatc tggctctttc cacatccaat ctttcatcaa 20700
cacttacaat ccctttctct tgctgatact ctgaaagctt cgattgcgct tgagctagat 20760
cttctctcag ttctttcaat tgctcaacga aatacaaagc agctttttga gaaggctcaa 20820
ctttaagttg tattgaagtt tgcatataag actcagcaaa ttcgtttgcg attgtagctg 20880
caaactgggg atttacccca aaaaagctaa tatcaataat actactctct cgagatggtt 20940
taacttgaag tttttttagc aataaatctg caagccattc tttaatttca cctttacctg 21000
aagttgcttg ataaaagtcc tcttttacgg ctggaacatc tgccagacct agtttatcaa 21060
ttaccttttt tgcaacgttt ttacttgaaa taatatccac ttgcgttgcc atataacctg 21120
gcattaactg cgcaggaagc attacacctg ttacaggatc agcgccttta taattaacaa 21180
gcactgaagc tgttgcttta taattttttg gcaacaatat tgtaacaata gcggtagtta 21240
ataccgttat aaataaagta aaaataataa ttttatatct agctttaatg atagaaataa 21300
atctgataaa actcatctta gattaccttt ttgattattc agctgttatt caaaaaacaa 21360
actaaaatac actctcttgt acatatacaa catcattagg ctgaataaaa tcatcatgct 21420
ttactttaat tatcttaaca ccaccttcat catctaaccg tttcacctta ataccttttt 21480
ccgttcccct gagactaagg ccaccaccaa cagcgagtgc ttgcagcact gtcatatgat 21540
actcaagacg atattgtcct ggccgctgaa cctcaccata tatatagaat ctaggagctc 21600
gatctacata aataatatct cctgccgtaa gtaagatatt tttatttaag tcgccatccc 21660
gcatcatttc agcaaaatca attatctctc taacactttt cccctcaatc ttgcgaacca 21720
agctaatcaa atctccccca tcaggtgcaa ctccaccggc caacgccagt acgtctgcaa 21780
gagattttgc actatccagt gggtagcgac ctggcctgtt aacctgacct agcacagaaa 21840
cctgctgact ctgcaactga gcaacaatga tattcacgtg agggtttttc aagaatccac 21900
cgctttccag catgctggca attttgcgtt cagcagctgc aggtgtttct ccaccgactc 21960
tgacttcgcc tatcaacggg taggtgatag tgccagactc actcactctt acttccaagg 22020
aaagatcagg ctgttcaaat acagatatcc ttagaacatc ccccggccca agaacaatat 22080
ccgaatccgc tgcgttaaca ttgaatacaa caatcgtcag gactaccgtt acaaaccatt 22140
tgatcaattt agtcatggca ctacacctat acacgtttta tagaattact actttagtcc 22200
gcttactccg cgagcaatat catcatcgac actagagggt tttgactgtt cggctttttc 22260
tggttgttgt ggtacttcgg ccgatttgtc taaatattca atttttgctt cagcccgtag 22320
tcgcttgatt tcagcctcac ccgcttcctt acgcttttta ttcaagagca tttgctcaat 22380
ttgcggtgtc gcatctgcca gtgataccgg gctctccttt acgctatcca tgagcaccag 22440
catcgtcctc ggtcccatgc cgatcacaaa cagctggcca cgccttgcat ccttcaggcg 22500
ctcagaaatc tgtggaggca gctctgccac actgcgggca acttctccac ggtcatattg 22560
gattccctta gcatccaacc acgcagcgac ttcctgcagg gttttgaagc taccgagcgc 22620
agacttgaat tcgtcattga cataacgtga atcaatcaat atttgttcca tttccaccag 22680
cttgcgctcg gaaaatagtt gagggttttg cttatagaaa ttctcaactt ctgttttgtc 22740
cggcttgcct atgttagcca ccctagactg gaggtatgcc tgggcaatca tttgggattt 22800
tgcgcgctca atggcttgca tgacgttcgg gtcccggtct acttttgctt tcaaggcagc 22860
ctgctccaac agttgacggt caatcaatga ttgcaatatc tgcttggtag cagcttcttt 22920
ctgcgctggc tggacattgg cccgagcaag ctcttcattg agttgatgga cggttatttc 22980
cttgccgttc actctcgcca gcgattggct agcctttgtt tcattagatt tatctccaca 23040
gcccgacagc ccgatactaa tcatcaaggc gaccaacgcc cctttcgtca ttttcgacca 23100
ttgcattatt gtgcttccat attcagtatt caaaatccag tctcctcaaa attcagccaa 23160
caccatcaat acgcattatc ttttttaaac actaccagca ccgtccggat gatgatccag 23220
agatcgaacg ccagcgacca atgcctgaga taatccaaat catattcaat ccgcgcttcc 23280
attttttcga gggtatcggt ttcacccctc aatccattca cctgggccca gccagtaatt 23340
cccggcttca ccttgtggcg caacatatag ccacgtatga gcttgcggta ttgttcatta 23400
tgcgccacgg cgtgaggcct cgggcctacg atactcattc gcccctgcaa cacattgata 23460
aactgtggca actcatcaag ggaatttctc ctgagaaaac caccaatcgg tgttaggcgc 23520
tggtcacgct tttgtgcctg caccactttg tcaccatctt ccatcactgt catggagcgg 23580
aatttgtaaa caatgatttc ctcaccattc aacccatacc tacgctgctt gaatattacc 23640
gggcctttag aagtcagctt cacagccaaa gccagtgtca gcatgatcgg tgaaagcaac 23700
aacaggataa gggatgcaag aataatgtca ctagtccgtt tgattaagct attaaaccct 23760
gtaaacggcg tttcacaaat cgccaccaca ggcacacccg ccacatcatc aaaccttgcc 23820
tgcaccagat caaaaatata gatatcgggc acaaaataga cagatgctgt cgtgtcttgc 23880
agctcctcaa acaactgtct gatgcgcggt tgcgcggaca tcggcagact gatgaaaatg 23940
atctgggtat tgttggcacg cacataagcc gccacgtccg ccattgtgcc tagcaacggt 24000
acatgacgca ttcccttggg atgccgggat atctcgcgat catcaaaaag acctttcacc 24060
tccatgaaca ggtaagggtc ttcattgatg cgattcacca accggacacc gatatcatta 24120
gcgcctacta tgacaacaga acgaacttcg ccatttttat gcaaatccga ggcaattttg 24180
cggatgagca aatgcgcaac agtaaagatg atcggcaccg ccacaaacca ggtatacacc 24240
atttcctcat ggtactgatc agtaaggtct gcggcatatc cgataaatgc caatatggtg 24300
acaacaattg cccatccgaa caaaatatca cgaatatagc ccaacacttt tccactacgc 24360
catgtgcggt aaagatccag gcgctcatag acatttgaag atacaaagta tgcaagcaac 24420
gcaaggatta agtagtagcc attgaatggc tcaccataaa gaagcgtaaa gccatacaaa 24480
gtccccagaa taattaaagg atctaacagc tgcttgaaaa aagcgactaa aggtatgtca 24540
tttaccgtca tttatagctc ttcaaaactc atattgccct gttactgaga cactatttga 24600
cctaaattca aacatatcag atgttgactc tcgatcacta tgaataaatg aagtagttat 24660
cctaaaagat gttactgggt tatacataag tgacagcata aaactcttat ctttatctga 24720
cctaaattga ccaaaaattt gatccccctc aaaatctctt ttttcatatt tcaatacgcc 24780
ttgaacagct atcttaccag ttgcctgcaa attagccgtt aatgatgttc cacgattcag 24840
cgtataactt gttgtaacaa atgactgagc gttattttct ctccaaactg cagcattcaa 24900
attggttttt ccagaagtca tccaattaaa gtttccccga gcattaaccc ccctaaagtc 24960
ccgttgagac agttgctcat gctgcctatc taccaaacca ccaagaaact gcaaccttga 25020
ctttccggta acagcccaat cgacattcaa ctttaattca ttctggtcat aatcattgct 25080
tataaaagat ccctgaaaag cttgctgcgg ctttgatcct ttagtatttc tgtacagaac 25140
accgatgata cttttagtag gagatagata gtcaaatccg atctcctgta tatcttcctt 25200
tagattagcg gccctttgag cctcagcccc gtactccatt tcagagtaaa taaaagcccc 25260
tctaacacgc catctaggat gcagcatcca acgcgcctcc aataagcggc ggtcctgagt 25320
tcttgtgttt aacgataaca tggttccttg cagaggttgg aattctgaaa aaggaaccaa 25380
agctttttta tgaaaaaact caaccttgcc ttccaatcga tttcccaact cccaatccca 25440
cctggcaata acgtcacgac catcattatc taactctgag tttttattaa atgtggactt 25500
gtttaatcta aaatccacat acattttttg acgactaata gtatgatcca gcacaatacc 25560
agcgcttttg acaagcattg tatctgaggt atctgaactc ccagtactca tttgagctaa 25620
ttgcttacta gcgaatcttc ttaaattatc atcatatgaa tatgtaagac tggcatacgg 25680
ctttaaaaca tccccctcta atgcacaagc agggactaca aatccagcaa gctcgatacc 25740
tagcccagcg accaaagcaa tttttattag gttagttgat tgagataacc gcaaagaagt 25800
gtttccccaa tgattaccag taatgccagt taccggtata tatgatccaa agtcccaata 25860
tgccatttgt caccgcatga gcgatgatcg gcaaccatat ttttccgcta cgaatataaa 25920
gcaagccgta tgccaagcca gccactaaac cggcaaacca ttcggtatgt tctattgcaa 25980
acaatgcgga tgaaactagt aaggccagga cgcttacctg ccgagggtcg acattgagga 26040
aatgttggtt gtgaatccag cgcatcaaga atgaacgcca gaacagctct tccatcaagg 26100
gcacgaccaa tgcggccccc atcactcttg tcgccatcag cagacgggca tccggtccgc 26160
ttcccggatc gaacccttcg gattgatcgc caatcaacat ccatggcgca tccagattga 26220
tccaggcgat aaatactagc ataccaacgg cgattgcgct caaccacgac ctggctccca 26280
gcgcggctag cccctggagc tcgacatact gcttgcgtag ataccaaagc aatagggcga 26340
ccagcccgac cttgatgcca tagagccaac gcgtatcggc gtccaccaag ccgatccgga 26400
ctaccaagtc caccactgcc atgaagagca tatacaatgc aaatggcgct acacggctca 26460
ggatcggcgt atgtaaacgg gataaaaaca tatgttgcaa attgaattca attggtcatc 26520
atacaaaact ttggtcacaa atgacacaaa ttctcattta ggtagtctgt tcggactaaa 26580
aaaaataagt cggcatcaag ccgacttatc gaatgctact gagctactgc gatagattta 26640
tgacaaatcc ctgcttttac ggcggcgcgc caccaatccc atcaacccca tgccgatcag 26700
catcaatgca tattcggatg gctcaggcac agcagccaca cggaaaccgc ttagccagat 26760
ttcctgaaac tggcggccgc cttcgttgct ggaagcgccc tggatgatgc ctatggcatt 26820
gctgccaagt tcaaacgtgt agcgggaggc atccacgc 26858
<210> 174
<211> 26858
<212> DNA
<213> 鞭毛甲基菌
<400> 174
gcgtggatgc ctcccgctac acgtttgaac ttggcagcaa tgccataggc atcatccagg 60
gcgcttccag caacgaaggc ggccgccagt ttcaggaaat ctggctaagc ggtttccgtg 120
tggctgctgt gcctgagcca tccgaatatg cattgatgct gatcggcatg gggttgatgg 180
gattggtggc gcgccgccgt aaaagcaggg atttgtcata aatctatcgc agtagctcag 240
tagcattcga taagtcggct tgatgccgac ttattttttt tagtccgaac agactaccta 300
aatgagaatt tgtgtcattt gtgaccaaag ttttgtatga tgaccaattg aattcaattt 360
gcaacatatg tttttatccc gtttacatac gccgatcctg agccgtgtag cgccatttgc 420
attgtatatg ctcttcatgg cagtggtgga cttggtagtc cggatcggct tggtggacgc 480
cgatacgcgt tggctctatg gcatcaaggt cgggctggtc gccctattgc tttggtatct 540
acgcaagcag tatgtcgagc tccaggggct agccgcgctg ggagccaggt cgtggttgag 600
cgcaatcgcc gttggtatgc tagtatttat cgcctggatc aatctggatg cgccatggat 660
gttgattggc gatcaatccg aagggttcga tccgggaagc ggaccggatg cccgtctgct 720
gatggcgaca agagtgatgg gggccgcatt ggtcgtgccc ttgatggaag agctgttctg 780
gcgttcattc ttgatgcgct ggattcacaa ccaacatttc ctcaatgtcg accctcggca 840
ggtaagcgtc ctggccttac tagtttcatc cgcattgttt gcaatagaac ataccgaatg 900
gtttgccggt ttagtggctg gcttggcata cggcttgctt tatattcgta gcggaaaaat 960
atggttgccg atcatcgctc atgcggtgac aaatggcata ttgggacttt ggatcatata 1020
taccggtaac tggcattact ggtaatcatt ggggaaacac ttctttgcgg ttatctcaat 1080
caactaacct aataaaaatt gctttggtcg ctgggctagg tatcgagctt gctggatttg 1140
tagtccctgc ttgtgcatta gagggggatg ttttaaagcc gtatgccagt cttacatatt 1200
catatgatga taatttaaga agattcgcta gtaagcaatt agctcaaatg agtactggga 1260
gttcagatac ctcagataca atgcttgtca aaagcgctgg tattgtgctg gatcatacta 1320
ttagtcgtca aaaaatgtat gtggatttta gattaaacaa gtccacattt aataaaaact 1380
cagagttaga taatgatggt cgtgacgtta ttgccaggtg ggattgggag ttgggaaatc 1440
gattggaagg caaggttgag ttttttcata aaaaagcttt ggttcctttt tcagaattcc 1500
aacctctgca aggaaccatg ttatcgttaa acacaagaac tcaggaccgc cgcttattgg 1560
aggcgcgttg gatgctgcat cctagatggc gtgttagagg ggcttttatt tactctgaaa 1620
tggagtacgg ggctgaggct caaagggccg ctaatctaaa ggaagatata caggagatcg 1680
gatttgacta tctatctcct actaaaagta tcatcggtgt tctgtacaga aatactaaag 1740
gatcaaagcc gcagcaagct tttcagggat cttttataag caatgattat gaccagaatg 1800
aattaaagtt gaatgtcgat tgggctgtta ccggaaagtc aaggttgcag tttcttggtg 1860
gtttggtaga taggcagcat gagcaactgt ctcaacggga ctttaggggg gttaatgctc 1920
ggggaaactt taattggatg acttctggaa aaaccaattt gaatgctgca gtttggagag 1980
aaaataacgc tcagtcattt gttacaacaa gttatacgct gaatcgtgga acatcattaa 2040
cggctaattt gcaggcaact ggtaagatag ctgttcaagg cgtattgaaa tatgaaaaaa 2100
gagattttga gggggatcaa atttttggtc aatttaggtc agataaagat aagagtttta 2160
tgctgtcact tatgtataac ccagtaacat cttttaggat aactacttca tttattcata 2220
gtgatcgaga gtcaacatct gatatgtttg aatttaggtc aaatagtgtc tcagtaacag 2280
ggcaatatga gttttgaaga gctataaatg acggtaaatg acataccttt agtcgctttt 2340
ttcaagcagc tgttagatcc tttaattatt ctggggactt tgtatggctt tacgcttctt 2400
tatggtgagc cattcaatgg ctactactta atccttgcgt tgcttgcata ctttgtatct 2460
tcaaatgtct atgagcgcct ggatctttac cgcacatggc gtagtggaaa agtgttgggc 2520
tatattcgtg atattttgtt cggatgggca attgttgtca ccatattggc atttatcgga 2580
tatgccgcag accttactga tcagtaccat gaggaaatgg tgtatacctg gtttgtggcg 2640
gtgccgatca tctttactgt tgcgcatttg ctcatccgca aaattgcctc ggatttgcat 2700
aaaaatggcg aagttcgttc tgttgtcata gtaggcgcta atgatatcgg tgtccggttg 2760
gtgaatcgca tcaatgaaga cccttacctg ttcatggagg tgaaaggtct ttttgatgat 2820
cgcgagatat cccggcatcc caagggaatg cgtcatgtac cgttgctagg cacaatggcg 2880
gacgtggcgg cttatgtgcg tgccaacaat acccagatca ttttcatcag tctgccgatg 2940
tccgcgcaac cgcgcatcag acagttgttt gaggagctgc aagacacgac agcatctgtc 3000
tattttgtgc ccgatatcta tatttttgat ctggtgcagg caaggtttga tgatgtggcg 3060
ggtgtgcctg tggtggcgat ttgtgaaacg ccgtttacag ggtttaatag cttaatcaaa 3120
cggactagtg acattattct tgcatccctt atcctgttgt tgctttcacc gatcatgctg 3180
acactggctt tggctgtgaa gctgacttct aaaggcccgg taatattcaa gcagcgtagg 3240
tatgggttga atggtgagga aatcattgtt tacaaattcc gctccatgac agtgatggaa 3300
gatggtgaca aagtggtgca ggcacaaaag cgtgaccagc gcctaacacc gattggtggt 3360
tttctcagga gaaattccct tgatgagttg ccacagttta tcaatgtgtt gcaggggcga 3420
atgagtatcg taggcccgag gcctcacgcc gtggcgcata atgaacaata ccgcaagctc 3480
atacgtggct atatgttgcg ccacaaggtg aagccgggaa ttactggctg ggcccaggtg 3540
aatggattga ggggtgaaac cgataccctc gaaaaaatgg aagcgcggat tgaatatgat 3600
ttggattatc tcaggcattg gtcgctggcg ttcgatctct ggatcatcat ccggacggtg 3660
ctggtagtgt ttaaaaaaga taatgcgtat tgatggtgtt ggctgaattt tgaggagact 3720
ggattttgaa tactgaatat ggaagcacaa taatgcaatg gtcgaaaatg acgaaagggg 3780
cgttggtcgc cttgatgatt agtatcgggc tgtcgggctg tggagataaa tctaatgaaa 3840
caaaggctag ccaatcgctg gcgagagtga acggcaagga aataaccgtc catcaactca 3900
atgaagagct tgctcgggcc aatgtccagc cagcgcagaa agaagctgct accaagcaga 3960
tattgcaatc attgattgac cgtcaactgt tggagcaggc tgccttgaaa gcaaaagtag 4020
accgggaccc gaacgtcatg caagccattg agcgcgcaaa atcccaaatg attgcccagg 4080
catacctcca gtctagggtg gctaacatag gcaagccgga caaaacagaa gttgagaatt 4140
tctataagca aaaccctcaa ctattttccg agcgcaagct ggtggaaatg gaacaaatat 4200
tgattgattc acgttatgtc aatgacgaat tcaagtctgc gctcggtagc ttcaaaaccc 4260
tgcaggaagt cgctgcgtgg ttggatgcta agggaatcca atatgaccgt ggagaagttg 4320
cccgcagtgt ggcagagctg cctccacaga tttctgagcg cctgaaggat gcaaggcgtg 4380
gccagctgtt tgtgatcggc atgggaccga ggacgatgct ggtgctcatg gatagcgtaa 4440
aggagagccc ggtatcactg gcagatgcga caccgcaaat tgagcaaatg ctcttgaata 4500
aaaagcgtaa ggaagcgggt gaggctgaaa tcaagcgact acgggctgaa gcaaaaattg 4560
aatatttaga caaatcggcc gaagtaccac aacaaccaga aaaagccgaa cagtcaaaac 4620
cctctagtgt cgatgatgat attgctcgcg gagtaagcgg actaaagtag taattctata 4680
aaacgtgtat aggtgtagtg ccatgactaa attgatcaaa tggtttgtaa cggtagtcct 4740
gacgattgtt gtattcaatg ttaacgcagc ggattcggat attgttcttg ggccggggga 4800
tgttctaagg atatctgtat ttgaacagcc tgatctttcc ttggaagtaa gagtgagtga 4860
gtctggcact atcacctacc cgttgatagg cgaagtcaga gtcggtggag aaacacctgc 4920
agctgctgaa cgcaaaattg ccagcatgct ggaaagcggt ggattcttga aaaaccctca 4980
cgtgaatatc attgttgctc agttgcagag tcagcaggtt tctgtgctag gtcaggttaa 5040
caggccaggt cgctacccac tggatagtgc aaaatctctt gcagacgtac tggcgttggc 5100
cggtggagtt gcacctgatg ggggagattt gattagcttg gttcgcaaga ttgaggggaa 5160
aagtgttaga gagataattg attttgctga aatgatgcgg gatggcgact taaataaaaa 5220
tatcttactt acggcaggag atattattta tgtagatcga gctcctagat tctatatata 5280
tggtgaggtt cagcggccag gacaatatcg tcttgagtat catatgacag tgctgcaagc 5340
actcgctgtt ggtggtggcc ttagtctcag gggaacggaa aaaggtatta aggtgaaacg 5400
gttagatgat gaaggtggtg ttaagataat taaagtaaag catgatgatt ttattcagcc 5460
taatgatgtt gtatatgtac aagagagtgt attttagttt gttttttgaa taacagctga 5520
ataatcaaaa aggtaatcta agatgagttt tatcagattt atttctatca ttaaagctag 5580
atataaaatt attattttta ctttatttat aacggtatta actaccgcta ttgttacaat 5640
attgttgcca aaaaattata aagcaacagc ttcagtgctt gttaattata aaggcgctga 5700
tcctgtaaca ggtgtaatgc ttcctgcgca gttaatgcca ggttatatgg caacgcaagt 5760
ggatattatt tcaagtaaaa acgttgcaaa aaaggtaatt gataaactag gtctggcaga 5820
tgttccagcc gtaaaagagg acttttatca agcaacttca ggtaaaggtg aaattaaaga 5880
atggcttgca gatttattgc taaaaaaact tcaagttaaa ccatctcgag agagtagtat 5940
tattgatatt agcttttttg gggtaaatcc ccagtttgca gctacaatcg caaacgaatt 6000
tgctgagtct tatatgcaaa cttcaataca acttaaagtt gagccttctc aaaaagctgc 6060
tttgtatttc gttgagcaat tgaaagaact gagagaagat ctagctcaag cgcaatcgaa 6120
gctttcagag tatcagcaag agaaagggat tgtaagtgtt gatgaaagat tggatgtgga 6180
aagagccaga ttaaatgagc tttcatctca attggttatt gcacaagcac aagttatgga 6240
agcgagatct cgggaaaaaa attcaagtgg aaaagaagct tatgagtctc ctgatgtagc 6300
agctaatcca attatccaaa atcttaaaac tgaaattgct agagcagaat caaggtttgc 6360
agatgtttcg cagaaatttg aaagaaacca tcctttttat ctaggagcta aagcagaaat 6420
tgaaaatctt aagtctgagc tagatagaca gatcaaatcg gtttcaagta atgtggcaag 6480
taattcaaga attctgcaac aacgtgaagc ggaaatacgt ttggctttaa ataatcaaaa 6540
agaaaaagta ttacaactta atcgagatag ggatatttta tctgttttga caagagaggt 6600
tgaaaatgct caaaaagcat acgacatggc tatgcaaagg tatactcaaa cgaatattga 6660
aggtcagtca aatcaatctg atatttcttt attgaatcct gccgtggcac ctcttactcc 6720
cactagccca aatttattgc tgaatattat attgtcaatc ctcttgggta tgtttttagg 6780
aatagggttt ggagttttag ctgagtttgt tgatcgaaga gtacggactg ctgatgactt 6840
aattgaagta ttacaagccc cacttcttgg gactattagt aaagaaaaaa gaaaactgag 6900
attttttaaa aatacttcaa acctgataac tttagggaag gctgaattat gatttcattt 6960
acaccttcta attcaaactc tgaaaaagta gaaaatgcac cattggtaaa cgaattttca 7020
gaatttacaa ttggtagttt attattgcgg atggggaaaa ttacacccga agatgctgaa 7080
agaattatgc ggttacataa agagaagggt ttgcgctttg gagaagctgc tcaagcatta 7140
gggttgataa ctgaagatga tattcaacag gttttatcga ggcaatttaa ctatccttat 7200
ttatcacctg accaaaactc atatcttaat gagctcgttg ctgcatatca gccttttagt 7260
aacaaagctg aggttttgag agcagtacgc agtcaattaa tgctgcattg gttttcaccg 7320
gaacgaaaag cactagctgt ttcttcagta agcagcagcg ataatgcaag ctcttttgtt 7380
gcaaatcttg cagttgtttt tgcgcaattg ggtgaaaata cattattgat tgacgctaat 7440
ttacgctacc cacgccagca tgagatatac aatctgagta acaaacgtgg gttatctgat 7500
atcttagcag gaagagcggg gtatgatgta atttcaaaaa taaatttttt tgaaaactta 7560
tctgtattaa ctgccggtac attacctcct aatcctcaag agcttgttag caagccaaca 7620
ttcggaaatt taattaaaga gttggcttgt gtttatgatg taattttatt ggatactccc 7680
gaacttagta attattcaga tggttatgca attgctttta ctgttggagg aattgtatta 7740
gttgcaagac aaaatcatac tcgagtgaat gatttatcta ttgctgtaga acaatgcaag 7800
aataatggta ctaaggtaat tgggtcaata ttggttgatt tgtagatatg aacactgtcg 7860
aggtaatcga gcaagataat cctggtatct gggaggtaat caatcggaat tggatgctat 7920
tattaggttt gttcattatg tatacgccta catatttgaa cttattaaat actgtatggc 7980
aatctgaaga tcaagctcat ggaccattaa ttgttggcgt tgtcttgtat ttagtatggg 8040
tacagagaca ccaattgttt aaggccgaaa ataatattat aggcaggcca gtaattggcg 8100
ggatagtttt agtttttggt cttttactct acattcttgg ccgttctcaa gatattgcac 8160
cgttagatat tgcatctcaa attcctgttt ttgctggatt gttgctaatt ttccgtggtt 8220
attctgggct tcgagcattg tggtttccgt tattcttctt gatttttatg gtgcctcttc 8280
ctggagtttt tcttgatgct gtgacattac caatgaagat tgcggtctca tatgtagcag 8340
aaaatatact ttattggata ggatatccga tttcaagaag tggggtgatc ctccaaatcg 8400
gacaatatca attacttgtt gcggatgcat gtgctggttt gcacacttta atatctttgg 8460
aggcgctggg tttactttat ttaaatgttg taaagcacga ttcatttatt cgtaatgtaa 8520
ttcttgggat attgattatt ccaatttctt ttaccgctaa tgtgattaga gttatggtat 8580
taactttagt tacttatcat tttggagatg ctgctggtca gggttttgtt catggttttg 8640
ctggaatgtt actttttgta gtggctctaa ttttgataat tagtgttgat acgctcctac 8700
aatatttggt taaaaaatgg cagttaaaag cctaaactct taataaggcc tgtctaatgg 8760
atggatttac actgcgaaat ttaattatat ttttactgtt attggtagct actttaggag 8820
gagtaattct taaacctact aagtttgtta atgcagcaga agatataaat ttagaagcaa 8880
tgattcctaa ggagttcgat gagtggaaaa tcgatcctac gattactcct atacaagtga 8940
gccctgaggt gcagcaaaac ctcaataaag tttatgatca aactctttct cggacctata 9000
ttaataagca aggaatgcga ataatgcttt cgattgctta tgggggagac caaagtcgcg 9060
gcttgcaagc acataagcct gaaacctgct atacagctca aggatttaat gttgatttgt 9120
tgggtaatgc cattttaaat tttgatggat atgaaattaa agttagacat ttattagccc 9180
agcatggggc acgatatgag ccaatacttt attggatgcg tgttggtgaa actacagttt 9240
atggtggatt gggtcaaact ataaaaaggt ttgaattagg tttgcaggga tatattcctg 9300
atggactgct ttttagagtt tcaagtatta gcagagataa tatctctgct tttacactgc 9360
aagaagaatt tgttaaatct ttactgaaaa atgtagatag taaaagtaga aaaaaactta 9420
taggtacatt ttcataaaat tcaatgtttt tttaacctaa ctttaataat aaaaatgtag 9480
caatttatga ttaaacatac cgcatttatg gctctttcga ctttttcacg gttgctatca 9540
gcggttgtac ttttcattat tcttgcaaga ttccttggtc cgagagactt tggcatattg 9600
atgtacaatt ttactcttgc gtcaatagct gtgcttttag tggaatatgg attttcaaat 9660
cagttgttaa gagatatagg aagataccct gataatatta atcagttaat ggggagggtt 9720
tttcttgcaa aactatatct cacagtagtg atgggggtct gttgccttgc tggacattac 9780
ttattctata caaatgactt agatagagca atattttgga ttttactgtt atcttgtttg 9840
ctcacttctt ttggggattt ttttaatatt gcattcagag gtatcggaaa atttcatgaa 9900
gaaacaaaag ttgcaacaat tggctctttg ttgcatttcg gcttaatagt tttaatggta 9960
attaatgggg ctgagttatt attaattagt ttaggttttg ttttatctcg ttttgtttat 10020
tttattttgt cgtggcgggc atataagcga gtggttggtg atttaaatac tctgtcagcc 10080
tctccagttg ctgttctaaa agcattaaaa gcaggatttc catatgccgt tgatgcgggt 10140
ttcactaact ttttctacca agttgacacc atgcttgtga aatattatct gggagccact 10200
ggagttggta tttaccaagc aggtatgaga tttctaaatg gtgcaatgca atttgcacct 10260
gtactcggaa atgtattttt acctgtaatt gctgccaagc acactaatac tagagagttt 10320
gttgagctag ctaaaaaact taatcttcag atgcttgctg ttggtactgt gtgctgggct 10380
attttctggt ttgccggtat gcatattacc gaatttgttt ttggtgatga atatgtagag 10440
ttaaattcaa tttggcccta tattggtttg ttagttttta caagatatct tgctgcgcct 10500
caaggtgttc tattgactgc ttctggatct cagacaatac gtgtctgggc acaaattttt 10560
gcacttatta ttttgctaat ttcagcacca cttctgatga aagtgattgg actaaaaggt 10620
atggtcattg ctttaatcat cacattatta accttgtttt tgatattttt cagtgcatta 10680
cggcttagaa aaatacctac tgggtttggg ggagttaatt ttactttgac tgtaatagta 10740
tttagtcttt ccatttttct tttggtatat tagtcatgtt gaaaataggc ttactttggc 10800
attctactac ttcagataat cttggtgttg gcgctttaac tgaagcacaa atttctatta 10860
ttaataaagc tgcggtgcag gcgggggttg aggttgaata tcgaattttc ggcactaatg 10920
gaaacaaaga ttactttgag ggcaaccctt taattgagcg agggacaaat gtatcactca 10980
aaagaatttt gatcggggct tctgattatc ccaagaaaat ccgggaatgc gatgtggtgt 11040
ttgatatagg tgaaggtgat agttttgctg atatttatgg tttttcacga ttcctaatac 11100
agattgtgtc taagttggtt gtcttgtttc aacgtaaacc tcttatttta agcccgcaaa 11160
ctatagggcc attcgaaagt aggtttaatt taaaggtggc caataatgta atgcagcggt 11220
gcactaaaat atttgtaagg gatggattgt catttggata cttgcaaaag aataatttat 11280
ctgtaaatgc agaggaggta attgacgttg cttttagatt gccatttcaa cgcccttccc 11340
gggattcaag taaagtaaaa attggactaa atgtatcagg attactttat aacggtgggt 11400
atactgggaa gaatcaattc ggtcttagtg ttaattatcc tgaacttact agatcactat 11460
tagatcagtt tactcgaata gaaggttgtg aagtatggct tgttcctcat gtgctaacga 11520
cctcatttcc tatagaagac gatgtgaacg tgtgtgttca attacaagag ctttatccag 11580
ctgctaagct tgcaccatct ttttcttctc ctagccaagc taaatctttt atttcaggga 11640
tggatttttt tcttggagct cgcatgcatg cttgtatcgc agcattttca agtggagtgc 11700
ctgttgtgcc attagcgtat agtaggaagt ttaatgggct tttttctgcc ttggattatc 11760
cttatcttgg ggattgtaag gttaatacta acgagcaaat agttggtttg gttatggatt 11820
gttttaacag tcgggagcag ttgaagtttg cagtagaaga aggtaataaa attgcagaaa 11880
aaaaactatt gcgttatgag cagtacatag cagaattatt aactagaatt tcaaataaaa 11940
agattgtttt ataagttaaa agtcaaattt actaagttga acacatattt tagagaatgt 12000
atagttgtaa gatgaaaaaa tacataattg gtttcttgcc gctttctatt aaatggcttc 12060
tgagattttg tcttcgaggc ccgagtttat tgagagactt ttgttacgat gctaaacgat 12120
atattaaatg gtcatctgta atttctttcg agaaagatcg tgaaaagatt cttgcggtta 12180
ttactgctac ttatcacaac atcgagaaag gaatgtcttt acctaatccc aggccgttat 12240
ttggaagggt agtgattgga caattagttg gatcagtcga taattttcat cttaattttg 12300
ggcctgatcc acagctagat gttccgataa atgtactggc gcgttattgt caatttaata 12360
gaagtcttgg tcagccagat tctcaattag aagtaatcgt tgatcggtta aagaaaaata 12420
atcagagcac tttattaagg attaatgatg gcggggttat tttgcgctct aaagctgagg 12480
ttttagacgc aatatctggg gttaaagaag atttttttct tatgcgccat agtgtaaggc 12540
agttcactaa agatcctata gagcatagtg taattgaaaa ggccgtacgt attgctcaaa 12600
aaagtccagc agtttgtaat cgacagtctg gaaaggtccg ggcaattctt aatccagaat 12660
taattaggag tactttacaa attcaagggg gcgcacgagg gttttatgaa gaggttcagg 12720
ctttattttg tataacagtg gatttgtcaa attttaatgg ggcggaacgt tatcaaggtt 12780
ggattgatgg gggaatgttt gcaatgagtt ttatatatgg cttacatttg caaggcctag 12840
gaagttgcgc tcttaactgg agtaaaacta ggaaacaaga tatagaaatg aggaatcacc 12900
ttcgtatacc agaaaacgaa ttaattatca tgtttgttgc cgctggatat ttaagggaat 12960
catttgttgt tccgcaatca taccgaaaac ctttaggtga agtcttgagt tatatttaat 13020
atatattaaa tattaggtag aaggtaccat taaaatttca caaggctaat gcgtcattat 13080
gaagaacaat tcttctctct tatcttttaa ccgtagggat gctaatttcg ttagtttaaa 13140
gatagggagt atattttttg taataatggc tgcaatagtg gctttgatat ttggttttgt 13200
cagtgctatt tttccatggt ggtggatagt agccattatt ctttctatat tatttatttt 13260
tattggtttt acatatcctt tagtagcttt aatagctgtt atagcaattt cttctagatt 13320
aattccagat acatttttgc cttcaataag actgctggga ggcacaatac catcttcaga 13380
tatggccttg tttgcaacat tcattttttg tttttttaaa tacaattcag aatttagctt 13440
tacaaagcaa gcattgtcac ctttggctat tcctttattt gttgtacttt tactgttgct 13500
tttttctgta tttcgggcgg tgtttgaaat tagattgcca ttgaaagata ttttagggga 13560
gtcaaggcat ttcctttatt ggctattgat tcccttaata gctttaacat gctcagatag 13620
acaaagattt aaatttattg tttttggctt tctttttgta gcttttttat tttcaattgg 13680
ccagattttg caaggttttc taggtgtaaa tgtgttcggg cgcgagctta ctagccttga 13740
aactttggga agcattaata gtgatgttac acgaagcatg acgtcaggaa ctcacattat 13800
tgtttgggga tttttgtttg tactggcttt gtttgctaac cgaataggtt tttcaaagac 13860
tcttattata ttgtgtatat ttacaggcgc tggaattttc ttaacctatg gtcgtgctgt 13920
ttgggggggg actttcttag ctgttttgtt cttatgctgg aagctaggga caaaaaaaat 13980
gcttagaagt gtaggactaa ttgcaattgt tgctgtattt ggtttaagtg ctatgctagc 14040
tattaagccg ggcgctattg aaggcgcgat gcagagattg tttagtgtgg aggaggaggt 14100
ttctcatgga tcttctctcg gctggaggtt ttatgaaaat aaaatggcat gggcggcaat 14160
tcagcggtca cctttattag gcattgggct tggtgcccct tataggccgc ctgctaaatc 14220
tgatgtgaca gcagagcaag tgagatatgt tcatagtgct tatatctatt taaccttaaa 14280
aacaggcatt attgtattca tgtcagtcat ttttcttata ttcaaaatac ttcatttaac 14340
ttacattcaa acgcggtcta atgatttatt tatatcaagt gttgccatag cttcttttgc 14400
tgcaatgata gagtattttt tggcctgcat tactcagcca gaattaatgc aaaccccggg 14460
aattgctttt ttggctactc ttgctggtct tatgtgcgcg gctaattatc ttaatcaaaa 14520
aaatcttaca aaaggaaagc taacttctta aagtgtaaat tggaatatat atatagtcat 14580
aattatataa aataatatga gaacttaaag atgaatgtta aaacatctcc attaattagt 14640
attattacgg caacatataa ttcaatgaaa tattttgagg atactaaaaa aagtgtcctt 14700
gaaggagatg ttgaagactt tgagtggatt atcgttgatg atggatccac tgatggaacg 14760
cggaaatatt tacaagaaat tgatcatcca aatataaaat tgcattttaa aagtattaat 14820
gctggtattg aagactcata tagaactggt attgaattgg cgaccggtaa atatttgcta 14880
attttagatc acgatgacac tattccattg ggatctttgt caaagcggct tgacttactg 14940
gaatcaaatc ccaatgcttt ggctgcattt ggtgctgtgg catatatgga tgagtctggg 15000
aggatttata aagaatcacg ttttcctttt gtatcagatg attgcgtact gtcatcacta 15060
tttactttat tcggaatctt tattttacca gtataccctt taaagcaagg gtgtgtggtt 15120
ttgaggtctt ctttcgttaa aaataatcca gggttatatg acatacaact attcctgcaa 15180
gctgctaaat tgggcccagt aatatttatc aagcaagcat gtttaaatta tcgaacattt 15240
agaacgcagt tttcaagttc tagaaaaatg cgattgattc gtttttttca atttgtttgg 15300
gcaaaatatg cgtttaaatt tctcccgtgg tatataagcc cgttctttgc tatttataaa 15360
acaataccag agttctttaa agtattatgg agttttgttt cttcaaaacg gatttaaaaa 15420
tatgttaacg attctttatt catggttgca atttttattg gtgcttattg atgacggatt 15480
ttagttcaaa aaaaaagtta gacttaagtg ttgcaatagt ttttgttaat tataatacta 15540
gtgaccaaat tatttcttgt atttactctc ttagggaaga gagatattca aagattattg 15600
ttgtggataa tgcatctccg gatgattgtc ctgagtgcat cgtagaagag tttccagatg 15660
ttgtacttat taaaagtgaa aaaaatcttg gctttggtga gggatgcaat attggaaaag 15720
attgggttat agttaataca gattgtgaat atatattttt tcttaatcca gacacactag 15780
ttgaacctgg attattacaa ttactgcatg atggattttt tagccctgaa gttggattgg 15840
ttaccccaag aattactatg atgggtgatg ggttggatat actttggtat ggtggggggt 15900
atatgaactg gttaactggt tcggcacgcg taccaggttg tggattaagt gctgtatcaa 15960
aaatagctct agaagatcga tttgtagagt ttgccagtgg ttgcgctttt atgattagac 16020
gttcagtttt agaagagtgt ggcgggttcg atccacgcta ttttatgtac gaagaagacg 16080
tcgaattatc tttaagagta atttcttatg gatataaaat ttattatatg ccaaaagctg 16140
ttgttcgcca tctggctcag ggtagccagg gcaaagaggt agaggctgtt ggtatgttta 16200
aaggaaggaa tcctaagctt cctttttttg tttatcaaac tgcgaaaaat agatttttaa 16260
ctgtttttac tcatggaact gtgcttaaga aaggtctatt tttaataggt tttatgttat 16320
gggtgtttcg aaactctttt gaatgggtca gatataagag acttgatgca tataatgctt 16380
tatttttggg cattaaagat tttgttaaat acacatatgt atcaggtaaa aaataattat 16440
tcagattggg tgttatgtga aagaaattaa cgtcgccttt gtggagccag ttggtagtca 16500
cggtggtatg gactattatg attctggact gtgtgccggt ttgttacatc agggagtatc 16560
tgcaacttgg tatacctgtg acatttctaa accttgtggt aatagaccta ttttcatgca 16620
acttactttt gtaaatattt ggggaaagga tgctacgtgg agaagagggg ctaggtatat 16680
cttagggctt tgtaggagca taaagcatgc taaaaaaaat tattcaaata ttgcccattt 16740
tcattttttt catgtgggtg ttttagaatt tttaagtgta ttattttttc gcttatttgg 16800
atttaaggtt gttgctacag tgcacgatgt tgagtctttt aagccgggtc taaccttctc 16860
tatcttgtta aaatggactt actttctctg taatcaatta attgtgcaca atcaagttag 16920
taaggatgag ttgattaata gaagtaatgt ttctataaat aaaatacatg taattcctca 16980
cggaagttat attggtctgg ttgcaccctc gatgccaaaa gcagatgctc gtcaagctct 17040
taatgtatca tcagatgaaa aggtaatttt attttttggt caaatcaaag aagtaaaagg 17100
tttggatttg ttgattgaag cgttaggttt ggttaaagat aaactaaaac catttaagct 17160
agtcattgct ggaaaagtgt ggaaagataa tttctctaag tatcaagaat taataagtaa 17220
aaacgggcta aatgattttt gtaaattgga tattagatac ataccagatc aagagatatc 17280
aatgttttat agtgcggcag acttgattgt tctgccttat agaaaaatat atcaaagtgg 17340
tgttttatta atggcaatga gttatggaac tccagtgtta gcttcagacc ttccgggtat 17400
ggcgcaaatt ataaatgatg gggaaaacgg atttttgttt tctgctggaa attatattga 17460
tcttgctgaa aagcttgtaa aaattttttc ttaccatgac ttatctagga ttactttgca 17520
agcagaaaac gatatgagaa ctcgcttcag ttgggatgag attgcgataa aaactatcag 17580
tgtttatcag aaaagtatat cgtaatgtgt atttgctaag attatggtaa acgggtttga 17640
tctaaaaata ttttgcggtg atgtttagta aaattcttaa tggggttagg attcttgatt 17700
ttttcatctt ctgaattgtg atgtcagtaa ataggctctt ttgtatgtta tatttatttg 17760
gattattttc cattgctata gcttgatagt gattatcttt gactttaata aggtatgagt 17820
tttttaattt aacttcggga gtaatcttta tatattaatt tttataggtg tcaattgtaa 17880
aaaataaatt ttaaagctaa taataaaatt agctaaataa ttagattatt ttgccgttaa 17940
taataggtgt ggatttttat ttacagtgtt tttttgaagt ggcgtgattt gatcgtatct 18000
agcctggagg tccataacta tgcaattaat taactctcga aggattgttt tacttagttt 18060
gttttccctt atgcctttgg ttggtattgc tgaagtttat aaatctacag atgtagacgg 18120
gagtaccact tattctgata cccctcaagc taattcacaa aagataaagg tttttccttc 18180
tgattataag aagaatgtta aatctgaggc tgcagctaat aaatccagaa gtaattctat 18240
ttctgctgct aatgttacag aagctcctat tgatgagtct agtagtgatt ctaatgtaac 18300
tataaagcat tcaacatcta ataaatctat caattcaagc aatccttctg ctgctggtgg 18360
ctcttcttct gctggtggct cttcttctgc tggtggctct tcttctgctg gtggctcttc 18420
ttctgctggt ggctcttctt ctgctggtgg ctcttcttct gctggtggct cttcttctgc 18480
tggtggctct tcttctgctg gtggctcttc ttctgaaaca actacagctg cttcggtcga 18540
taaggtttct gcggctttgc aaggaccgaa agcttttctt aattcagacg attttaaaga 18600
aaattcttat cgagggttta atgttcttgg gcggaaatta agttctgctg acatggaaga 18660
tcttgaaaag tttaacgtca atttaattcg aagcgttatt catttggaaa aatgtaaaaa 18720
atgtaatgat tatgaaattt ctccagttga gttgtcgcaa atggattttc ttgtggaggc 18780
aggtcgtaag ttgggatttt atgtaatttt tgcttttgat cctaaacctg ctggagatca 18840
ggcgatctac tggaataatc aacaattacg agaaagcatt aagaataact gggtaactat 18900
tgctaaaaga tacaaaaatg agactgtggt ggcagggttt gacctgatta atgagcctgt 18960
tgttaggcct ggatcagtat gggaaaagta tgctactgaa ttgattactg ccatacgtaa 19020
agtagatgaa aatcatataa tttttctgga acctagtcct tgggggctgg cttctagttt 19080
ggagcagttt actcctgttc catttaataa tatagtttac agctttcatt tttattctcc 19140
ccaagaactt actcatcaag gattggcggc atacccacat gcatatatat atcccagtga 19200
aaagtgggat aaagaatacc taaataatcg actagacatt gctcgtaatt gggctaataa 19260
atataatgtt cctctttata tcggtgaatt tagcattatt cggtgggctc cgtctggttc 19320
gaggttacgt tacttgacag atgtagttga gcgctttgag caagagaaat ggtcatggac 19380
atatcatagc tatagagaat atagcggatg ggatgcggaa atgccagata gtatattcaa 19440
gaatgatgct attgtcgaac gtcaaaacaa tgttcctgta cttcagcttt tgatgaaaaa 19500
ttttaataaa aataagaaat attagaatca catttaacat gagtttgtat ttgtatgcat 19560
aagaaaatag caatattagg aaccagagga attccggctg cgcatggtgg ctttgaaaca 19620
tttgcagagc atttggctat ttatcttgaa agaaaagggt ggaaagtaac agtttattgc 19680
caagtagatg gtaatgggcc tatgtatgag gatatgtgga atggtataaa gcgagtaaat 19740
attccgatat ctatccaggg ttctttaggc actattcttt ttgattggaa gtcaacgatt 19800
catgcttcaa atacttatca tcttatttta actcttgggt ataacactgc tttattctgt 19860
gggctctata gaactaaagg aataactaat ctaattaata tggatggaat cgagtggcat 19920
cggaaaaaat ggggggcagt tgctaaactc tggttctgga ttaatgattg ggctggttca 19980
attttaggca atcatctgat tgctgatcat ccgcaaattg cgcgtcatct ggaaacaaga 20040
gtcaggccta gcaagatcac aatgattcca tacggcgcag ataaagtgat tgaggcgaat 20100
caggccgttt tggaggaata tggacttaag cctttcagtt atgcgatctt aattgctcgt 20160
gcagagcctg aaaattctat tttagaggtg gtgaaagcct ggtccgctaa acctcgaggc 20220
atgaggcttg tagtgctagg aaaatataac cctgaccatg cttatcaggt cgcggttaaa 20280
gctgccggct cagacgaggt gctttttcct ggcgcaattt atgataaaca cgtggtcgaa 20340
tctttacggt atttctcaag attatatatt cacggccacc aagttggcgg caccaatcct 20400
tctttggtgg aggcactagg ggctggtaat gcagtattgg cgcacgataa ccgttttaac 20460
cgctgggtcg ctggagataa ggcggcctac ttttctggtg aaaaggactg cgaaatcact 20520
cttgatgagc ttcttaatga tgaagttcgg ttacgtgaga tgagagccgg tagcttggct 20580
caatacgata ccttatttac ctgggactca gtgttgcagc aatatgaggc cttgctgaca 20640
aggtttttgc caaataagta attagatact gtgcctattt ctttcccttt atatttctat 20700
ccagtgagaa aattatgcag attcaagccg tgattttatc aggtggctct ggcacaaggt 20760
tgtggcctct ttctcgagaa aactatccca agcaattgct gacattgctt gataatgatt 20820
ctttacttca gtcgacatta cgcagggtcg atccactcat tggaaccgag tgttctccaa 20880
ttctggtatg taatgaagaa tatcgctttg ttatcgctga gcaattgcgg atgatgggaa 20940
ggcgtggatc tattctcctt gagcctgtag gcaagaacac tgcccctgcg ctcaccttgg 21000
ctgccttaga ggctgccagc cacggccagg atccaatctt acttgtcatg cccgccgatc 21060
acgctattat caatgtgcaa gactttcagg ataccgtgag gacaggggct gaacatgccg 21120
ctgctggtaa gatcgtcacc ttcggtatcg tgcccgatag ggcagaaact ggctatggtt 21180
atatcaagtc aggcgcagtg ctggaaggtt tcggttctgc tttcagtatt gagcagtttg 21240
ttgagaagcc tgatgaggct actgctcagc aatatgtagt aagtgggaat tatttctgga 21300
acagcggtct gttcatgatg cgtgccacgg tatggctgaa tgcgattgct aagactcgtc 21360
cagatatctt atcttcatgt aagcaggctt gggatggtca acaacgcgat ggcgattttg 21420
ttcgggtgga caagcttaaa tttcaacagg tacctagcga ttctatagac tatgcggtga 21480
tggagcatgt cgctcgtggt gccgataatc tgcctgcagg catagtcatc cccctgaatg 21540
ccggctggtc agatgttggg gcctgggatt cattcgggaa aattttgccg caggataacg 21600
cgggtaactc ccatttagga gatgtgctgt tcaatgattg ctcgaatact ctagctgtgt 21660
cttcaggtag gctgcttgca tgtgtgggtc tgcaaaacat cgcggtgatt gagacagcag 21720
atgcggtgct agttatagat aaaagtaaaa ctcaggatgt gaaaaaaatc gtggagcagc 21780
ttaaggtcca gaaaaggccc gaggccaaga ctcaccgcaa ggttcaccgc ccctggggct 21840
ggtatgacag tattgatatg ggggcacggt tccaagtaaa acgtattgta gtgaatccag 21900
gtgctacgtt atctcttcaa atgcatcacc atagagccga gcactggatt gtggtgaccg 21960
gtacagcgaa ggtaacaaga ggagatgagg agttccttgt ttctgaaaac cagtctactt 22020
atattccttt aggtgtgacg catatgctgg ctaatccagg aaagcttcct ttagaaatga 22080
tagaggttca gtctggggct tatttgggtg aagatgatat tgttcgcttc aatgatcaat 22140
atggacgttc atgaataatt tcccttggtc tgactgaagt cagttttaat gattaattag 22200
taataatgct aatgattttc gaccgagaat gttgctaagt gggttactgt agatcgcaaa 22260
gccaattccc atggtgctaa ttcagttttg aaagtgctca tgaatttttc agtgctcatc 22320
ttggagttgg cggggcgatg agctggtgtg gggtattctg cagttgtaat accgacaaca 22380
ttttctacag tggattttaa tttcgctaaa tttttctttt gggctatttc tccatactgg 22440
cgaatgattt ccagtgcaaa gccatgccag ctcgtctccc cagtattgac taagtgatag 22500
acacctcttt gagtcccatc ccatgcgtgc agcgcagtaa tagttgcatc tgcaatgctt 22560
tcggtagaag ttggtgcgcc aaactggtct gcgactatat tcaatgagtc acgctcggca 22620
gctaatctca atatggtgcg catgaaattt tttccatatg caccataaac ccagctggtc 22680
ctgaagatta gatgatttgc tccgacttct tgaatggctt tttctcctgc taacttgctg 22740
gctccataaa cgctaagtgg atttgtttca tccaattctg tgtaaggggt agttttggtg 22800
ccatcaaata cataatccgt agaataatgc acaagcaatg catttagctt tgctgcttct 22860
tcagccagaa tgccgggagc agtgccattg atggcgtagg ccagctccgg ctcagattcc 22920
gctttatcca cagcagtata agctgcaggg ttgattatga ggtctggttt ggtctgtcgc 22980
actacgtccc ggatatggtc aggtttggat aggtcaagtt ggctgcggtc aagtgcaacg 23040
acttctccca agctttgtag tttcggatag agagcatggc ctacctggcc gttgatgccg 23100
gtaagcagga tcttgttgaa agttgccatt atgcgaataa ctctgtctgg tggaggccta 23160
agccttgttg atctttactt gagaggagcg ggggcgtgcc aatatctggc cattcaatac 23220
caacaacggg atcgttccag cttaggcaac gttcatgcgc aggcgcgtag aagtctgtgg 23280
tcttatagag aaactctgca gtttcggaca gcacgaggaa gccgtgggca aaacctggtg 23340
gtacccacat ttgtttcttg ttttctgctg acagatgttg ccctacccat tgaccaaagg 23400
ttggagaaga tttgcggata tccacggcaa cgtcaaaaac ttcacctgct actactctaa 23460
ccaattttcc ttgggcttgc tggatctgat aatgtagccc tctcaatact ccttttgagg 23520
attttgagtg gttgtcttgt acaaaatcat atttcctgcc gacggcttcc tcaaaggctt 23580
tctgattgaa gctttcaaaa aagaatcccc gggcatcacc gaatatcttg ggttcgaata 23640
cgatcacatc aggaatatgg gtgggcgtga cattcattaa aagacctttt ctttcagcat 23700
ccggatcaaa tattggccgt aaccattctt gaggtatggc tgggcaattt tttctacttg 23760
ttctgcatcg atgtaacctt tgcggtaagc gatttcttcg gggcaggcga ctttcaggcc 23820
ttgtcgcttt tctatggttt cgatgaatag tgaggcttct agcagggatt catgcgttcc 23880
tgtatccaac caggcatgac cgcgccccat caattccaca ttgagggagc gcctttccag 23940
gtaaattttg ttgacatcgg taatttcaag ttcgcctcga ggagatggtt tgaggctggc 24000
ggcaatgtca acgacctggt tgtcatagaa atacagtcca gtaacggcat agcgggattt 24060
tggctctttg ggcttttctt ccaggctgat agcctggcca gcatcgttga actcgaccac 24120
gccataacgt tcagggtcgt gaacagggta ggcaaataca gtggcgccat gctgccgttg 24180
atcggcatgt gccaggtcat gtgccaggtc atgaccatag aagatgttgt cgccaagcac 24240
cagggcactt ggatcattgc caataaattt cttgccgatg ataaaggctt gggccaatcc 24300
atctggggag ggctgtactg cataggcaat attgagtccc cattgactgc catcacccaa 24360
tagctgttca aagcgtggtg tgtcctgcgg agttgagatc aggaggatgt cgcgtatccc 24420
agccagcatg agcgtggaca agggatagta gatcatgggc ttgtcataca cgggcagcag 24480
ttgcttggag actgcctggg tgacagggta aagccgggtg cccgatccac cggcgaggat 24540
gatgcctttt ctcatgctgc gctcccgcta tattgcttgc tgacccagtt gcggtattct 24600
ccactggtga cgttgtgcac ccatgcctgg ttttgcagat accattccac ggtttttctg 24660
atgcctgact cgaaggtttc cgcaggcttc cagcccaact cgcgctccag tttgcttgca 24720
tcgattgcgt agcgccggtc atggcctgga cggtccttga cgaatgtgat ttggtctttg 24780
tagcttgagc catctgcctt ggggctgagt tcatccagga tgctgcataa ggtctgtact 24840
acatcgagat tggccttttc gttccaaccg cccacattgt aggtttcccc gagctggcct 24900
gcttccagta cgcggcggat ggcgctgcaa tgatccttga cgaatagcca gtcgcggatt 24960
tgctggccgt caccgtaaat aggcaatggt ttaccagcaa gcgcattgag caggcatagt 25020
ggaatcaatt tttcagggaa atggtaaggc ccatagttat tggagcagtt ggtggtcaat 25080
accggcaagc cataagtgtg gtggtaggca cgcactagat gatccgaggc tgccttggaa 25140
gccgagtatg gactattggg ggcgtaaggg gtggtttccg taaacgcttg gtccttgggg 25200
cccagtgtgc catacacctc atctgtagag acgtgcagga agcggaactg aggattttct 25260
ttttcctctg ggtgggtttt caccacgcta ttccagtagg cgcgtacttc ttccagtaag 25320
tggaaggtgc cgactacatt ggtctgaatg aagtcttccg ggccatggat ggaacggtca 25380
acatggcttt cggcggcaaa gttgatgact gcacggggtt tgtgttctgc cagcaacttg 25440
gcgaccaagg cgcggtcacc aatatcgcca tgtacgaaga tgtggttggg gttgccttca 25500
atgtctgcca ggttttcaag atttccggca taggtcaatt tgtccaggtt gatgacggtg 25560
cctagtcctg ccttgaccca gtcgagtacg aagttgccac cgatgaagcc tgcgccacca 25620
gtgacaatga tagtgttatt taatgtcgtc aatctattaa ctcacttaat atctggatta 25680
tttgcgggtg tggtgaaatt attatttact ggtttatatt acaagaaggc tatcacagaa 25740
tggtagctta actttctaat tcagattttt ttaaaagttt tctatgttta taaagctact 25800
ataaatatgt gtggcgcttc aatagggcta ttggactaaa ggaaaagttt ttaatgttat 25860
tagtaacagg cggtacaggc tacataggtt cccacgcatg tgtggaactg attaatgcgg 25920
gctatgaggt ggtggtgctg gataatttca gcaatagcca ggcgcatatc gttgaccgca 25980
tcaagcagat cacgggcaag gcacccgtat tggtggaagg ggatgtgcgg gatgaagcac 26040
tactgagtga tttattttct aggtacccat tccaggcagt catgcatttt gccgggctca 26100
aggcggtggg ggagtcggtc gcgcagcctt tgcgttatta cgataacaat gtggcgggta 26160
gtgttacctt gctgcgcgtc atgcaggcgc atgacgtcaa acgattagtc ttcagttcgt 26220
ccgctactgt gtatggcgat ccagccagtg tgccgattcg cgaggatttc ccgttgtctg 26280
cgaccaatcc ttatggggca agcaagctga tggtggagga tatcctgcgc gacttggcag 26340
tctccgatcc agagtggcgt attgccatcc tgcgttattt caatcctgtg ggcgcgcatg 26400
agagcggcct cattggtgag aacccgaatg gtatgcccaa taacctcatg ccatacatca 26460
cccaggtagc ccaggggcag cgtgaatctc tttctgtgtt tggcagtgac tatccaaccg 26520
tggatggtac gggcgtgcgc gactacatcc atgtggtcga cctggtggtt ggccatttgc 26580
gtgccctgga gcggctggat aaggaagctg gtgtgttcac atgcaatctt ggcacgggcc 26640
aaggatatag cgtgctggaa atggtcaagg catttgaaga cgccagtggc caggctgttc 26700
cctatcagct ggtggcacgc cggccgggtg atgtggcggc cagttatacc gatcctgctt 26760
atgccgagca ggcattgggt tggaaagcga cgcgtggcat cgagcagatg tgcaaggata 26820
gttggcattg gcagcaaaac cttgcccaga gaggctga 26858
<210> 175
<211> 13733
<212> DNA
<213> 鞭毛甲基菌
<400> 175
gtgaggagac tccttgatga acgtagttta aacatactct tgtaatccaa gagtttaact 60
tgggatgaga tattctgaat tggttgaagc gtaatctttt aaaatttttg ggatgtgtgt 120
tatttagtat tatgattttt atgatgtttt tttattgtta aatattgttt ttagtagcaa 180
tattttttat ataattagat ttcatattga atgctcaaga tttaatttaa ttcagtattt 240
aaaactcttt aggtataatg agccaatttt ataaaaaagt tttttaatgc tgcttcctgt 300
cattatgtct ggcggggccg gttccagatt atggccggtt tctcgtgaaa ctctaactaa 360
gccatttatc gaattacctg atggcagaac ccttctgcag aagactttgc aacgtactgc 420
ttgcctggat ggtgtgagcg aagtgctcac agtaacgaat aaggaatatt acttcctgac 480
acgtgatgtc tatgaggcaa cagacactaa tgtttcccat agctacttac tagagacgat 540
agggcgcaat actgctcctg ccattgcagt tgctgcacta catgccgctg cgaaacatgg 600
ggaagatgta gtgctgttgg tgatgccggc agatcatctt attggtaatc aaaaagtttt 660
ttcaaaagca gtgactgttg cgacagatat ggcggtgaat ggctggatag tcacgtttgg 720
tgtagagcca agcacgcctg aaacaggtta tggctacatt gaaggcggag agtcaattgg 780
ggactcaggc gcgcgtagag tcgttcgatt tgtcgaaaag ccagatttgg aaactgctga 840
gaaatatatt gctttaggtc gatttacatg gaatgcaggt atattctgtt ttactgcaaa 900
aaccattatt gctgcacttg cggagtatgt tccagaagtg cttgagatag caaaaaagac 960
cctggcatct agtgactcca aaactgagcc tgttgtattg ggcgaggagc actttgcatc 1020
aagtccagat atttccatag attatgccgt catggagcgt gcttcaaaag tggcggtagt 1080
cgcagctgat tttgactgga gcgacattgg ttcatggagc gccatggctg agttggtcca 1140
gtcagatgag cgtgggaata gggtgaatgg cgaagcttta ttggtggatg ctaataattg 1200
ctatatccaa agtgattccc gtcttgtggc tggtataggt attgataacc tgctggtggt 1260
cgatacaccc gatgccctgc ttgtggctca tcactccaga gctcaggatg tcaaaaccgt 1320
tgtgaagcaa ctcaagcttg agtcccatag tgcggcaaat taccatcgca aggtacaccg 1380
tccatggggc acatacaccg tattggaaga aggcgctaat tttaagatca aatgcatcaa 1440
ggtaaagcct ggtgccagcc tgagcttgca aatgcaccat catcgtagtg agcattgggt 1500
tgtagtaagc ggtatagcta aagttgtcaa cggcgagcgc gagctgctca ttaatgccaa 1560
tgagtctact tacattccag caggacacaa acaccgtctt gaaaatccag gtttgcttga 1620
cctggtgatt attgaagttc aatccgggga atatttgggc gaagacgata ttgttcgttt 1680
tcaagatatc tacggacgca cttgatgatc agcatgttaa aagccttatg gctttatcgc 1740
ggctttgtgt tgggcagcgt caagcgcgag tttcaatcca agtaccgtaa ttcgctgcta 1800
ggcgcagtct ggacggtctt gaaccccctc gcaatgatcg tagtgtacac agtgattttc 1860
tcgcaggtaa tgaaggctcg tttgcctggc gtggacagta cttttgcgtt tagcattcat 1920
ttatgcgctg gcatactcac ctggggcttg tttgctgaga ttgtcgggcg ctcacagacc 1980
acgttcatcg ataatgccaa cttgctcaag aaactgagtt tcccccgtct atgtctgcca 2040
gtcatcgtca ccgccaccgc gctagttaac tttgccattg tttttgggtt gttcacagcg 2100
ttcttgctgc tgatcggtat gttttcgggt tggccttatt tggtgctgat cccggtattg 2160
atactgatga tcgtctttgc tctaggcttg ggtattatat tgggcgttct caatgtgttt 2220
ttccgcgatg taggtcagtt ctttggcatt gtgcttagtt tctggttttg gcttacgccg 2280
attgtctatc cggtcagcat tcttccagaa cgggtacaag attatatgcg gcttaacccc 2340
atggcgcgct tgatggaggc tttccaagga atattggtac aagcaaaatg gccggactgg 2400
tacagtctat ggccagtgtt tgcgctgtct atcgtgttgt gcctgctggg gctgtcttta 2460
ttccgcaaac atgcgggcga tatggtggat gaactttaat gggtactatt gttgtcacca 2520
acctgggtaa ggcctacaag caatacccca gtcgctggtc tcggttgttg gagtggatag 2580
atctgaggcg taagccgcac caccaattga agtggattct gcaaggagta agttttcata 2640
tccagccagg agagacggag gcagctttgc cgtgactgct gccaagcgtt ctaatacgag 2700
tattaagcct aaccttgcag tgatcaattg gatgcttgag caagaagacc ggatgggatt 2760
atctacccca aggccttatc gtgaatttga ggagcgtgta tatcgtcatc gcgatgatct 2820
caggcgctta attcattcgt tagtagctga cggcaaaaaa atatatgggt atggagcttc 2880
tgccaaaggt aatgtagtac tacaattttg tggctttact tctgaggaaa tccctgccat 2940
tgcagaagta aacgaagaaa aattcggacg agtcactccg ggaacgcata ttcccattat 3000
ttcggaaaaa gaggcgcgcg ctgccaagcc cgactacttc ttggtgcttc catggcattt 3060
caaagatggt atcctgcgcc gtgaaaagga ctttctagct gatggcggca ggtttatctt 3120
cccatttcct gagatcgaaa tcgtctagtt tccaaaaaaa gatgaaggaa aataataaga 3180
taatttagac gctgttctaa cgaatccatt atttacatac catatataca tatacagtaa 3240
gactttaaat acataaggca taatacgatg accataaaaa ctgccatcat taccggcatc 3300
acaggccaag atggtgcata tctcgcagaa cttctcctta gtaaaggcta taaggtttac 3360
ggtaccttcc gccgtacaag ctcggtcaac ttctggcgta ttgaagagct gggaattgaa 3420
aatgacccaa atcttctttt ggttgaatac gacctgaccg atttgtcagc aagcatccgt 3480
ctattgcaga gcacaggtgc aacagaagtg tacaacttag ctgcgcaaag ttttgtgggc 3540
gtgtcttttg agcaacctat tactaccgcg gagatcacag gtgtcggtgc gctcaatctt 3600
ttggaggcca ttcgtttagt aaatcccaat attcgctatt accaagcatc cacatccgaa 3660
atgttcggca aggtgcaggc gattccacaa acggaagata cgcctttcta tccacgcagt 3720
ccttatggtg tcgccaagct gtatgcgcac tggatgactg ttaactatcg tgaaagctat 3780
ggaatcttcg gatctagcgg tattttattc aatcatgaga gtccgttgcg tggtcgcgag 3840
ttcgtgacgc gcaagatcac ggattcggtg gccaagatca agctggggaa acttgattgc 3900
ctggagttgg gtaacttgga tgcaaagcgt gattggggct atgccaagga ttatgtggaa 3960
ggcatgtggc gcatcctgca ggcggatgag ccggatacct ttgtactggc gaccaatcgt 4020
accgagactg tgcgcgattt tgtaagcatg gcgttcaagg gggctggcat tgctgttgag 4080
ttcaagggca agggcgagga cgaagttgcc gtggatactg caaccggtaa gatagtggtt 4140
cgggtcaatc cgaagtttta ccgtccagcg gaagtggacc tactgatcgg tagcccagcc 4200
aaggccaagg ccaagctggg ttgggaaccg aagacaacgc tggagcaact ctgccagatg 4260
atggtcgagg ccgatctgcg ccgcaacacg gaaggtttct cattttgaga attctgctta 4320
ctggtgctga tggattcacc gggcgccatt ttctgacggc cgcgaaagcg gccggccatg 4380
aggttgttgc actgagggcc gatttgacgg acaaggctgt attgcaacgc gaagttgagg 4440
cggctcgtcc ggaagcagtg gttcatctgg cagcgatcag ttttgttggt catgcggatg 4500
ttagtgcctt ttatgacgtc aatgtgatcg gtaccctgaa cctgttggat gcgctggctg 4560
gcttgtccgt gacgccgcgc agcgtactgc tggcaagcag tgcgaatgtg tatggcaatg 4620
cagcgcattc acctatcacc gaagagcagg cgccggcgcc ggtcaatcac tatgcaatga 4680
gcaagctggc catggagcac atggcccgta cctatctgga cagactgccg ttgttttttg 4740
tgcggccgtt caattacacg gggccggggc aggctgagtc tttcgtgatt cccaagctgg 4800
tggcgcattt cgcgtgcaag gcgcagaccg tggaactggg caatctggat gtggagcgcg 4860
agttcaatga tgtggctttc gtttgcgagg cctatctgcg tttgttggac aaggctgtgc 4920
cgggtgaggt gtttaatatc tgcagcggtg ctccggtgac attgcgtgca gtaatcggga 4980
tgttgaggga attgacggcg catgatatcg aggtcaaggt aaatccgcag ttcgtgcgga 5040
ataacgagat caagacatta tgcggtgatc catcaaagct gttccgtact attggagagg 5100
ggaggctggt tcctttagcg cttaccttga agatcatgct ggaacacgct acgcgaaaag 5160
aaaaaaaatg atgaaggtag gttttggtgt caccgtgctt acacgttgcc tggcattggg 5220
gggaatcgat ggaattggta gttatacccg ggagctgatg aaaagactcg aggctgaccc 5280
ggccgtcgag cttttcccta tctcgtacgg gtattctccg tcacagtttc ctatcggctc 5340
acgtgctccg acgacatttg gacgatatgc gccgcttgct gcagtatcgg ctgtatccgg 5400
gtttcccttt ctgggaacag ctcaattgaa ggagcgtgtt gatctgattc atgcgcctga 5460
tcatcttatt cccaactacg gaaaagttcc tgttattgca tccatcatgg acgcgattcc 5520
cttgtcgcat ccggagtggg tatcccccaa gttgcgcaag atgaaaaatg cgttatggaa 5580
gcgctctgcg cactgggcat cgcatatcat tactatctct gagtattcga agcaggaaat 5640
ttcacagcat ttcggtattg aggcacaaaa gatcagtgcc atcccgcttg gcgtggatga 5700
gcggtggttt cagccgttgg aagaagaggc gatgaaggtg gtattgagac ggtacaatct 5760
gcctcaatac tattttcttg tcgtggggac gctgcagcca aggaagaatg tcggccgggt 5820
aatcgaggca tatcggtcct tgccccaagg gatacgtaac gaagtgccgt tggtgattgt 5880
tggtagggca gggtggcgat gcgaggatgt ggttgaaatg ttgacttcgt cttcttcagg 5940
aaattctctg aggtggctca agcatttgcc ggatgccgac ttgcttgcag tgttgaaagg 6000
tgcaacggct ttggtctttc cttcgttgta tgagggattt ggtttgcccg tagtcgaagc 6060
ttttgcggct ggaactcccg ttattacttc caataccact tctcttccag aggtggcggg 6120
cgatgccgcc atgctggtga atcctctgaa tgtcagcgac attgccgctg caatgcaatc 6180
gatgctggaa cagccggaac tggcagagag tttcaggaac aaggggcaag aacgcgcatt 6240
ggcatattcg tgggacaaaa cagcctccat gacgcttgac gtctataaaa agacgcgaga 6300
ggctgcttaa catcaacgca ccgtcaaaca tcgcactcct tcccttttta tgatcatccg 6360
ttttctgggc gcacagtggc tcgccgttgg ttttgtcggg gtcatctctc tggcggtcag 6420
cattttgatt gcgcggacgc ttgggccgga ttcatttggt gtttattcgg ttgtcttgtc 6480
cggcggagcc attgccgcca ttctgcttga tggtggtttc gggcgattgt tgcaaagaga 6540
acgcgcccat cccacacctg cattgctcag attcctgccc atattgccgc aggctgcctt 6600
ggggcatgtg attatcgcgg ccagcatatt ttcgttgatc gctttattgg tactgcccaa 6660
gcatgcgctg acgattgttg cggttatctg gtttttcgca gcatctgtga ccaatcagtt 6720
cggtttgaac attctccgcg gagatgggcg gatggtaagg gatgcctcgt ggcagatggg 6780
caatcgaacc ttcacagctg cgtgcgtgtg cattgtcatt ctgatgggag ctgagaaacc 6840
gtggcaggta ttctttgccc agtttgtcgg tgcgaccgcc ttcggtttgc tgatcatgca 6900
ctatctgcgc acgcgcccgc tatggaagat tcctcctact ctttatgcgg caaccttgcc 6960
attcgtgtgg ttggatctcg cgacagtcct ttattttcga gcggacatgc tgttgctgga 7020
atggttagat gtgtccaagt ttgaagtcgg gaaatacggg gttgcctgcc gcttgattga 7080
ggcggtgatt ctgcttgctt cgccgctctg tattattttg ttccgcaagt ttcgtctggg 7140
tagcgcttct ccccgactga tgttgcggag aatgctgccg gtgctggcag gggcgctgat 7200
ggttggagtg ttcttcatgg tgtttttctg gttgtgcagc acgcctttga tcgcggttgc 7260
atatggcgag gcctatgcgg gagctgatca tattctggcg atactcggct gcgctttgct 7320
ttttattttg ccaaatggcg tgctgaacca agctgcgcta gcgctgggta tcgaacgttg 7380
gctggcaatg tcggcatctt ttgccgcagt gctaaatatt gcaggaaatc tctggctgat 7440
tccccaatat gggttgattg gagctgcctg gatgactgtt gtgaccgaag cggtgttagg 7500
ctgctgcgtt gcgttagggc tatggcgcca ccgtaatagg agtgtttaat gcaggatctt 7560
gccgttgctc atgtttatcg tacctatttt cctgaccctc caggcgggtt gcaggaggca 7620
attcgccaga ttgccctcac gacgggtatg cagggcgtcg ataatacggt gtttacgctt 7680
tctccgcagc cgcgtccggc aatcttgcag cgtccggagg cttgtgttgt tcgttgccgc 7740
tcctgggcgg ctccggcatc atgcgatctg ggcggtatcg gcgcatttct tgcgttttcc 7800
aggttggcgg aaaaatctga tgtgctacat tacctttttc cgtggccatt tgcggatgtt 7860
ctgcatacgg tggttcgccc aggttgtccg gccgtcatga cttatatctc ggacgtggtg 7920
cgtcagcagc ttttagggag gttatatgct cctttgatgt ggaaggtgtt gcgccagatg 7980
aggcttgtgg tggcgaattc tccagcgtat gcacgcacca gtcccgttct ctcccatcct 8040
gagattcgcg aaaaagtcag ggttattcca cttggtattg aggagtcttc ttatcctaaa 8100
tcaggggatg aggagattct gcagcgtcta ggcattggga aggatgagcc ttattttctt 8160
tttattggcg ttcttcgtta ttacaaaggc gcgcattttc tggtcaaggc agcaaagcgg 8220
ataggcgcaa aggtggtgtt tgctggcgcg gggccggaag gcgcgcgcct gaaagcattg 8280
gctggcgaag tcggtgcaga gaatgtgatt tttgccggga tggtgactaa cgcggaaaaa 8340
gtaaccttgc ttcaatgctg cagagcgctt gtgttgccat cgcatttgcg gtctgaagcg 8400
tacggcatgg tgctggtaga ggctgccatg ttcgggaagc cgctgatttc ttgcgaaatt 8460
ggcacaggca cttcatatgt caaccatcat gaagaaacag ggtttgtcgt tgagccggcc 8520
tctcctgaag cattggcgtc ggcgatggcg gttttgttat cagaggatag gctggctaca 8580
gagatgggag ctgctgctcg tcagcggtat gagctgctct tttccggccc ggcattagga 8640
aaggcatatg ctgcattgtt ccgcgaagtt gacgcttcgt agcagagtgc gtcatgatga 8700
agtagccaga gttgtaacgt ttttgggatt atcctgttgg ttttcttgat tgttaataca 8760
tgatgcaatt actggtgaca ggcgctacag ggtttgtagg taaaactttg tgcagtgcgc 8820
taaggcggca gagcttcccc gtaaaagcaa ttgggcgtgc gggcactatc cgggctgacg 8880
ctttgggtga tcaggttgct tcaattgacg gtcaaacgga ttggtcactg atattggacg 8940
gcatcaatgc cgtcatccat ctggcagcca gggtgcacgt catgcgggaa cagcttgctg 9000
atcccttggc ggcatatcgt gaaacgaatg tcgaagggac gctgaatctg gcgcgtcagg 9060
cggcaaaggc cggagttaag cggtttgtat tcattagttc catcaaggtc aacggcgaac 9120
agactctacc tggaaagcct tttactgcgt acgatgtacc agctcccgaa gatgcgtacg 9180
gtatttcaaa gttcgaggca gagcagggtt tgctggccct ggcgcgggag acagggatgg 9240
atgtggtggt tattcgccct cctttggttt acgggcctgg agtgaagggt aattttgcca 9300
gtatgatgaa gttggtgaaa agtggaatac cgttgcctct gggcgccatt cataaccaac 9360
ggtctttggt ggcgattgat aatttggtga acctcatcgt cacgtgtatt gaccatcccg 9420
cggcagccaa ccaggttttt ttggtaagcg atggcgagga tttgtccact tcagatttgt 9480
tgcggcgttt ggccaaggct gcgggcgttt cctcccgatt gatgccagtg tctgcccgct 9540
ggctagagat gggtttgcgt atgtgtggca agcgattgat cgcccagcgt ctcctgggat 9600
cattgcaagt cgatatttcc aagacgcgcg agttgttggg gtgggttccg ccgatctcag 9660
tggatgaggg cttgaagcgc tgtttctcta ccaagggctg attcttgatc cgattttttg 9720
acattatttt ttcggtgata ggcttggtac tgggattccc gctattgcta tcgatttata 9780
ccctcggctt gtttgataca ggtgctccct tgtttcgcca ggtgagggtt gggcgctacc 9840
ggcagccgtt tactttggtg aaatttcgga cgatgaaggt ggatacggct tctgtggcga 9900
gccatctggc ttccaccaat tccatcaccc ggctcggacg gttcttgcgc aggaccaagc 9960
tggatgagct gccccagctc tggaatgtcc tgaagggaga aatgagcctg gtggggcctc 10020
gaccgaacct gttcaatcag gaggagctga tggccgagcg cgagttgcgt ggcgtttacc 10080
atgcgcggcc agggattacc ggccttgcac aggtgaatga tatagacatg tcgacgccaa 10140
ggctgcttgc cgagaccgat gccaggatgc tgcgcgagat gaatgtacgg ctttatttca 10200
agttgctgat tcagacggtg ctgggtcgag gacagggcga ccgggtcgtg cgctgagctc 10260
ggcaggaacc aatgcctggc tacaaagtgt tgatccatga ttggtcgtca ctgtcccgtg 10320
gtttttagta gaatgttatt cattttcact ttaggctggg cgcgtgctgc attatttccc 10380
ctcattcaag tggtcgaact acatcagttt gaagaatcca cgctctttga gcgcttggat 10440
atatgacatt gttgctgctg cgctggcatg gtgggcagcc ttcctgttac ggttcaattt 10500
tgatattccg gccaattttg tccagagtat gctcgacagc gcagcatggg tgattccgct 10560
gcaggcattt gtgtttctgc tggctgggtt gtacaaaggc gtctggcgtt ttgccagcct 10620
gccggatttg cagcgcttgg tgcgcgcgat tgcgatcagc gcagtgcttg tggttgcgat 10680
cttgttcatg ttcaagccac acggcattgt tcctcgctcg gtgctgatct tggatcctat 10740
gctgttgctg ctgttgatgg gcggcagccg ctttgcttac cgagcatgga aagaacatcg 10800
cctgtatggt tctgcccagt tttccggaaa gccggtgctg gtgctcggcg cgggtgaggc 10860
agcgattgcc ttgttgaagg atctttccaa aagccgtgaa tggcatgtcg ttgggttgct 10920
ggacgataag aaaaccatgc atggccgaga gctactgggc gtcaatgtgc tggggtcgat 10980
tgcgcaattg ccacagatcg ctgcggattt gtcggtcaat catgtgattg tggccatgcc 11040
atccgcgcgt catcaacgac gcagggaaat cgtcgagctg gcaagcagaa atgggctgac 11100
tgcgctcacg gtgccgtcgt ttgatgacct gatgagtggc cacctgagca tggcacagat 11160
tcggccggtc gaggtggagg acttgctggg gcgggagccg gtcagtctcg atggagaggg 11220
gctccagcat ttgatcgagg ggcaggtgtt gctgattact ggtgcaggtg gttccatcgg 11280
ttctgagtta tgccgccagg tgctgaaata ccgtccagct tgcctggtct gcctggatca 11340
gtcggagtac gcgttgtatc ggttggagca ggagtttgac aatctggagt ttgatacccg 11400
cattgaatac gtggttggcg atgtcaggaa cgcacgccgg gtggggcagg tgcttggccg 11460
ttatatgccc aaactggtgt tccatgctgc tgcgtataag catgtgcctt tgatggagaa 11520
ccgcaatgtg gcggaatcat tgtcaaataa tgtcagcggt acttacacgc tcgcccaggc 11580
atgcaaaact gcaggggttg ccaagttcgt gctgatttcc accgataagg cggttaatcc 11640
caccaatgtg atgggggcca gcaagcgcct ggcggaaatg atatgccaag gcctgcagga 11700
ggagtcgggt acgcgtttta tcgtggtgcg ctttggcaat gtgctgggca gtagtggcag 11760
tgtaatcccc aagttccgtg agcagattgc ggcgggcggg ccaattaccg ttacccatcc 11820
cgagatcact cgctatttca tgtccatccc ggaggcgtgc cagctggtca tgcaggctgg 11880
attgatgggt ggtggcgggg agatatttgt gctggatatg ggagaccctg tgcggattgt 11940
ggacttggcc cgtgatatga tccggttatc cgggcttaat gaagatgaca ttcagattgt 12000
atactctggc ttgcggcccg gcgaaaagct gtacgaggaa cttttggctg acgacgagct 12060
cactgtacca acaccccacg acaagctacg tattgccgtg gcgcgaagcg tggatggtgc 12120
ttgggttcag gcattgctga aatggatcga cagggcatcg ctcatagatg aatctgtcat 12180
caagcaagag ctgggcatgt gggtggagga gtatgcaggg gatattcatg ccaatccatc 12240
catgatgttc ccccccgagt cttcaaccat acattagaag aaagatagat agaaatggca 12300
aaaaaaatta ccaaggcagt atttccagtg gcaggtttag ggacacgttt cctgccagca 12360
accaaggcga gtcccaagga aatgttgcca attgtggata agcctctgat tcagtatgca 12420
gcagaggagg ctgtggccgc cggtgctacc gagctgattt ttattatcgg gcgcaacaag 12480
cgcaccatcc cggatcattt tgataagtcc ttcgagctgg aagcgacgct tgaggcaagc 12540
aagaaaacca aggtgctgga agaaatccgc aatatcctgc caaaaaatgt ttcctgcatc 12600
tatattcgcc aggccgaggc gcttggtttg gggcatgcgg tattgcttgc caagtccgtg 12660
gtcggcagcg agcctttctc tgtgatcctg gccgatgacc ttattgatgc cgacaaacct 12720
gccatgcagc agatgacaga gctgttcgac caagagggtg tcagcattct gggtgtcgag 12780
gatgtggagc ccagtgagac ggcaagctat ggcattgtgg atgcgacaga ggtgagtggc 12840
ccgaatgtgt tgcaattgaa tggcattgtg gaaaaaccgc agccggaaga agcgccctcc 12900
aatctggctg ttgtcggtcg gtatattctc acgcctgaaa tttttgaatg cctggagaac 12960
gtcaagccgg gcaagggcgg ggaaatccag ttgactgatg gcattgccgc cttgatggaa 13020
aaacagaaaa tcctggctta ccgtttcgat gggaagcgct acgattgcgg cagcaagctg 13080
ggttatgtca aggcgaacgt cgagtattcc ttgaagcatg aggagtttgg caaagagttt 13140
gcccagtact tacgtgatct aaccaagtag cagtcgtggt ggtacttgag ggtaaccccg 13200
atctcattct gcagcgatcc acgctggtct cttctgaaga ggaagtgaag caggcggtga 13260
cgagggtggc gcaggaaatc actgccacgc taaggcagga ccaacctctc gtcctgtgtg 13320
tcatgggagg cggggtggta ttcaccgggc aattattgcc acagctggtt ttccctttgg 13380
agttcggtta tgtgcaggcc acccgctatc acaaccggac acatggcgat gcccagctgg 13440
tgtggaaaat gaagcccggg gaggaggtgc gcggccgtac cgttttattg ctcgatgata 13500
ttctcgatga gggggtcacg ctggcagaaa tcaaggcgca gtgtctggca ctgggtgcca 13560
gcaaggttgt cgttgcggtc ttggttgaaa aaatgctggg gcgggtcaag ccgatcaggg 13620
ctgatttcgt cggactggag gtgccggacc agtatgtatt cggatgcgga atggatgcct 13680
atgggtggtg gcgtaatttg ccggccattt atgccatgca aggggaagct tga 13733
<210> 176
<211> 13733
<212> DNA
<213> 鞭毛甲基菌
<400> 176
tcaagcttcc ccttgcatgg cataaatggc cggcaaatta cgccaccacc cataggcatc 60
cattccgcat ccgaatacat actggtccgg cacctccagt ccgacgaaat cagccctgat 120
cggcttgacc cgccccagca ttttttcaac caagaccgca acgacaacct tgctggcacc 180
cagtgccaga cactgcgcct tgatttctgc cagcgtgacc ccctcatcga gaatatcatc 240
gagcaataaa acggtacggc cgcgcacctc ctccccgggc ttcattttcc acaccagctg 300
ggcatcgcca tgtgtccggt tgtgatagcg ggtggcctgc acataaccga actccaaagg 360
gaaaaccagc tgtggcaata attgcccggt gaataccacc ccgcctccca tgacacacag 420
gacgagaggt tggtcctgcc ttagcgtggc agtgatttcc tgcgccaccc tcgtcaccgc 480
ctgcttcact tcctcttcag aagagaccag cgtggatcgc tgcagaatga gatcggggtt 540
accctcaagt accaccacga ctgctacttg gttagatcac gtaagtactg ggcaaactct 600
ttgccaaact cctcatgctt caaggaatac tcgacgttcg ccttgacata acccagcttg 660
ctgccgcaat cgtagcgctt cccatcgaaa cggtaagcca ggattttctg tttttccatc 720
aaggcggcaa tgccatcagt caactggatt tccccgccct tgcccggctt gacgttctcc 780
aggcattcaa aaatttcagg cgtgagaata taccgaccga caacagccag attggagggc 840
gcttcttccg gctgcggttt ttccacaatg ccattcaatt gcaacacatt cgggccactc 900
acctctgtcg catccacaat gccatagctt gccgtctcac tgggctccac atcctcgaca 960
cccagaatgc tgacaccctc ttggtcgaac agctctgtca tctgctgcat ggcaggtttg 1020
tcggcatcaa taaggtcatc ggccaggatc acagagaaag gctcgctgcc gaccacggac 1080
ttggcaagca ataccgcatg ccccaaacca agcgcctcgg cctggcgaat atagatgcag 1140
gaaacatttt ttggcaggat attgcggatt tcttccagca ccttggtttt cttgcttgcc 1200
tcaagcgtcg cttccagctc gaaggactta tcaaaatgat ccgggatggt gcgcttgttg 1260
cgcccgataa taaaaatcag ctcggtagca ccggcggcca cagcctcctc tgctgcatac 1320
tgaatcagag gcttatccac aattggcaac atttccttgg gactcgcctt ggttgctggc 1380
aggaaacgtg tccctaaacc tgccactgga aatactgcct tggtaatttt ttttgccatt 1440
tctatctatc tttcttctaa tgtatggttg aagactcggg ggggaacatc atggatggat 1500
tggcatgaat atcccctgca tactcctcca cccacatgcc cagctcttgc ttgatgacag 1560
attcatctat gagcgatgcc ctgtcgatcc atttcagcaa tgcctgaacc caagcaccat 1620
ccacgcttcg cgccacggca atacgtagct tgtcgtgggg tgttggtaca gtgagctcgt 1680
cgtcagccaa aagttcctcg tacagctttt cgccgggccg caagccagag tatacaatct 1740
gaatgtcatc ttcattaagc ccggataacc ggatcatatc acgggccaag tccacaatcc 1800
gcacagggtc tcccatatcc agcacaaata tctccccgcc accacccatc aatccagcct 1860
gcatgaccag ctggcacgcc tccgggatgg acatgaaata gcgagtgatc tcgggatggg 1920
taacggtaat tggcccgccc gccgcaatct gctcacggaa cttggggatt acactgccac 1980
tactgcccag cacattgcca aagcgcacca cgataaaacg cgtacccgac tcctcctgca 2040
ggccttggca tatcatttcc gccaggcgct tgctggcccc catcacattg gtgggattaa 2100
ccgccttatc ggtggaaatc agcacgaact tggcaacccc tgcagttttg catgcctggg 2160
cgagcgtgta agtaccgctg acattatttg acaatgattc cgccacattg cggttctcca 2220
tcaaaggcac atgcttatac gcagcagcat ggaacaccag tttgggcata taacggccaa 2280
gcacctgccc cacccggcgt gcgttcctga catcgccaac cacgtattca atgcgggtat 2340
caaactccag attgtcaaac tcctgctcca accgatacaa cgcgtactcc gactgatcca 2400
ggcagaccag gcaagctgga cggtatttca gcacctggcg gcataactca gaaccgatgg 2460
aaccacctgc accagtaatc agcaacacct gcccctcgat caaatgctgg agcccctctc 2520
catcgagact gaccggctcc cgccccagca agtcctccac ctcgaccggc cgaatctgtg 2580
ccatgctcag gtggccactc atcaggtcat caaacgacgg caccgtgagc gcagtcagcc 2640
catttctgct tgccagctcg acgatttccc tgcgtcgttg atgacgcgcg gatggcatgg 2700
ccacaatcac atgattgacc gacaaatccg cagcgatctg tggcaattgc gcaatcgacc 2760
ccagcacatt gacgcccagt agctctcggc catgcatggt tttcttatcg tccagcaacc 2820
caacgacatg ccattcacgg cttttggaaa gatccttcaa caaggcaatc gctgcctcac 2880
ccgcgccgag caccagcacc ggctttccgg aaaactgggc agaaccatac aggcgatgtt 2940
ctttccatgc tcggtaagca aagcggctgc cgcccatcaa cagcagcaac agcataggat 3000
ccaagatcag caccgagcga ggaacaatgc cgtgtggctt gaacatgaac aagatcgcaa 3060
ccacaagcac tgcgctgatc gcaatcgcgc gcaccaagcg ctgcaaatcc ggcaggctgg 3120
caaaacgcca gacgcctttg tacaacccag ccagcagaaa cacaaatgcc tgcagcggaa 3180
tcacccatgc tgcgctgtcg agcatactct ggacaaaatt ggccggaata tcaaaattga 3240
accgtaacag gaaggctgcc caccatgcca gcgcagcagc aacaatgtca tatatccaag 3300
cgctcaaaga gcgtggattc ttcaaactga tgtagttcga ccacttgaat gaggggaaat 3360
aatgcagcac gcgcccagcc taaagtgaaa atgaataaca ttctactaaa aaccacggga 3420
cagtgacgac caatcatgga tcaacacttt gtagccaggc attggttcct gccgagctca 3480
gcgcacgacc cggtcgccct gtcctcgacc cagcaccgtc tgaatcagca acttgaaata 3540
aagccgtaca ttcatctcgc gcagcatcct ggcatcggtc tcggcaagca gccttggcgt 3600
cgacatgtct atatcattca cctgtgcaag gccggtaatc cctggccgcg catggtaaac 3660
gccacgcaac tcgcgctcgg ccatcagctc ctcctgattg aacaggttcg gtcgaggccc 3720
caccaggctc atttctccct tcaggacatt ccagagctgg ggcagctcat ccagcttggt 3780
cctgcgcaag aaccgtccga gccgggtgat ggaattggtg gaagccagat ggctcgccac 3840
agaagccgta tccaccttca tcgtccgaaa tttcaccaaa gtaaacggct gccggtagcg 3900
cccaaccctc acctggcgaa acaagggagc acctgtatca aacaagccga gggtataaat 3960
cgatagcaat agcgggaatc ccagtaccaa gcctatcacc gaaaaaataa tgtcaaaaaa 4020
tcggatcaag aatcagccct tggtagagaa acagcgcttc aagccctcat ccactgagat 4080
cggcggaacc caccccaaca actcgcgcgt cttggaaata tcgacttgca atgatcccag 4140
gagacgctgg gcgatcaatc gcttgccaca catacgcaaa cccatctcta gccagcgggc 4200
agacactggc atcaatcggg aggaaacgcc cgcagccttg gccaaacgcc gcaacaaatc 4260
tgaagtggac aaatcctcgc catcgcttac caaaaaaacc tggttggctg ccgcgggatg 4320
gtcaatacac gtgacgatga ggttcaccaa attatcaatc gccaccaaag accgttggtt 4380
atgaatggcg cccagaggca acggtattcc acttttcacc aacttcatca tactggcaaa 4440
attacccttc actccaggcc cgtaaaccaa aggagggcga ataaccacca catccatccc 4500
tgtctcccgc gccagggcca gcaaaccctg ctctgcctcg aactttgaaa taccgtacgc 4560
atcttcggga gctggtacat cgtacgcagt aaaaggcttt ccaggtagag tctgttcgcc 4620
gttgaccttg atggaactaa tgaatacaaa ccgcttaact ccggcctttg ccgcctgacg 4680
cgccagattc agcgtccctt cgacattcgt ttcacgatat gccgccaagg gatcagcaag 4740
ctgttcccgc atgacgtgca ccctggctgc cagatggatg acggcattga tgccgtccaa 4800
tatcagtgac caatccgttt gaccgtcaat tgaagcaacc tgatcaccca aagcgtcagc 4860
ccggatagtg cccgcacgcc caattgcttt tacggggaag ctctgccgcc ttagcgcact 4920
gcacaaagtt ttacctacaa accctgtagc gcctgtcacc agtaattgca tcatgtatta 4980
acaatcaaga aaaccaacag gataatccca aaaacgttac aactctggct acttcatcat 5040
gacgcactct gctacgaagc gtcaacttcg cggaacaatg cagcatatgc ctttcctaat 5100
gccgggccgg aaaagagcag ctcataccgc tgacgagcag cagctcccat ctctgtagcc 5160
agcctatcct ctgataacaa aaccgccatc gccgacgcca atgcttcagg agaggccggc 5220
tcaacgacaa accctgtttc ttcatgatgg ttgacatatg aagtgcctgt gccaatttcg 5280
caagaaatca gcggcttccc gaacatggca gcctctacca gcaccatgcc gtacgcttca 5340
gaccgcaaat gcgatggcaa cacaagcgct ctgcagcatt gaagcaaggt tactttttcc 5400
gcgttagtca ccatcccggc aaaaatcaca ttctctgcac cgacttcgcc agccaatgct 5460
ttcaggcgcg cgccttccgg ccccgcgcca gcaaacacca cctttgcgcc tatccgcttt 5520
gctgccttga ccagaaaatg cgcgcctttg taataacgaa gaacgccaat aaaaagaaaa 5580
taaggctcat ccttcccaat gcctagacgc tgcagaatct cctcatcccc tgatttagga 5640
taagaagact cctcaatacc aagtggaata accctgactt tttcgcgaat ctcaggatgg 5700
gagagaacgg gactggtgcg tgcatacgct ggagaattcg ccaccacaag cctcatctgg 5760
cgcaacacct tccacatcaa aggagcatat aacctcccta aaagctgctg acgcaccacg 5820
tccgagatat aagtcatgac ggccggacaa cctgggcgaa ccaccgtatg cagaacatcc 5880
gcaaatggcc acggaaaaag gtaatgtagc acatcagatt tttccgccaa cctggaaaac 5940
gcaagaaatg cgccgatacc gcccagatcg catgatgccg gagccgccca ggagcggcaa 6000
cgaacaacac aagcctccgg acgctgcaag attgccggac gcggctgcgg agaaagcgta 6060
aacaccgtat tatcgacgcc ctgcataccc gtcgtgaggg caatctggcg aattgcctcc 6120
tgcaacccgc ctggagggtc aggaaaatag gtacgataaa catgagcaac ggcaagatcc 6180
tgcattaaac actcctatta cggtggcgcc atagccctaa cgcaacgcag cagcctaaca 6240
ccgcttcggt cacaacagtc atccaggcag ctccaatcaa cccatattgg ggaatcagcc 6300
agagatttcc tgcaatattt agcactgcgg caaaagatgc cgacattgcc agccaacgtt 6360
cgatacccag cgctagcgca gcttggttca gcacgccatt tggcaaaata aaaagcaaag 6420
cgcagccgag tatcgccaga atatgatcag ctcccgcata ggcctcgcca tatgcaaccg 6480
cgatcaaagg cgtgctgcac aaccagaaaa acaccatgaa gaacactcca accatcagcg 6540
cccctgccag caccggcagc attctccgca acatcagtcg gggagaagcg ctacccagac 6600
gaaacttgcg gaacaaaata atacagagcg gcgaagcaag cagaatcacc gcctcaatca 6660
agcggcaggc aaccccgtat ttcccgactt caaacttgga cacatctaac cattccagca 6720
acagcatgtc cgctcgaaaa taaaggactg tcgcgagatc caaccacacg aatggcaagg 6780
ttgccgcata aagagtagga ggaatcttcc atagcgggcg cgtgcgcaga tagtgcatga 6840
tcagcaaacc gaaggcggtc gcaccgacaa actgggcaaa gaatacctgc cacggtttct 6900
cagctcccat cagaatgaca atgcacacgc acgcagctgt gaaggttcga ttgcccatct 6960
gccacgaggc atcccttacc atccgcccat ctccgcggag aatgttcaaa ccgaactgat 7020
tggtcacaga tgctgcgaaa aaccagataa ccgcaacaat cgtcagcgca tgcttgggca 7080
gtaccaataa agcgatcaac gaaaatatgc tggccgcgat aatcacatgc cccaaggcag 7140
cctgcggcaa tatgggcagg aatctgagca atgcaggtgt gggatgggcg cgttctcttt 7200
gcaacaatcg cccgaaacca ccatcaagca gaatggcggc aatggctccg ccggacaaga 7260
caaccgaata aacaccaaat gaatccggcc caagcgtccg cgcaatcaaa atgctgaccg 7320
ccagagagat gaccccgaca aaaccaacgg cgagccactg tgcgcccaga aaacggatga 7380
tcataaaaag ggaaggagtg cgatgtttga cggtgcgttg atgttaagca gcctctcgcg 7440
tctttttata gacgtcaagc gtcatggagg ctgttttgtc ccacgaatat gccaatgcgc 7500
gttcttgccc cttgttcctg aaactctctg ccagttccgg ctgttccagc atcgattgca 7560
ttgcagcggc aatgtcgctg acattcagag gattcaccag catggcggca tcgcccgcca 7620
cctctggaag agaagtggta ttggaagtaa taacgggagt tccagccgca aaagcttcga 7680
ctacgggcaa accaaatccc tcatacaacg aaggaaagac caaagccgtt gcacctttca 7740
acactgcaag caagtcggca tccggcaaat gcttgagcca cctcagagaa tttcctgaag 7800
aagacgaagt caacatttca accacatcct cgcatcgcca ccctgcccta ccaacaatca 7860
ccaacggcac ttcgttacgt atcccttggg gcaaggaccg atatgcctcg attacccggc 7920
cgacattctt ccttggctgc agcgtcccca cgacaagaaa atagtattga ggcagattgt 7980
accgtctcaa taccaccttc atcgcctctt cttccaacgg ctgaaaccac cgctcatcca 8040
cgccaagcgg gatggcactg atcttttgtg cctcaatacc gaaatgctgt gaaatttcct 8100
gcttcgaata ctcagagata gtaatgatat gcgatgccca gtgcgcagag cgcttccata 8160
acgcattttt catcttgcgc aacttggggg atacccactc cggatgcgac aagggaatcg 8220
cgtccatgat ggatgcaata acaggaactt ttccgtagtt gggaataaga tgatcaggcg 8280
catgaatcag atcaacacgc tccttcaatt gagctgttcc cagaaaggga aacccggata 8340
cagccgatac tgcagcaagc ggcgcatatc gtccaaatgt cgtcggagca cgtgagccga 8400
taggaaactg tgacggagaa tacccgtacg agatagggaa aagctcgacg gccgggtcag 8460
cctcgagtct tttcatcagc tcccgggtat aactaccaat tccatcgatt ccccccaatg 8520
ccaggcaacg tgtaagcacg gtgacaccaa aacctacctt catcattttt tttcttttcg 8580
cgtagcgtgt tccagcatga tcttcaaggt aagcgctaaa ggaaccagcc tcccctctcc 8640
aatagtacgg aacagctttg atggatcacc gcataatgtc ttgatctcgt tattccgcac 8700
gaactgcgga tttaccttga cctcgatatc atgcgccgtc aattccctca acatcccgat 8760
tactgcacgc aatgtcaccg gagcaccgct gcagatatta aacacctcac ccggcacagc 8820
cttgtccaac aaacgcagat aggcctcgca aacgaaagcc acatcattga actcgcgctc 8880
cacatccaga ttgcccagtt ccacggtctg cgccttgcac gcgaaatgcg ccaccagctt 8940
gggaatcacg aaagactcag cctgccccgg ccccgtgtaa ttgaacggcc gcacaaaaaa 9000
caacggcagt ctgtccagat aggtacgggc catgtgctcc atggccagct tgctcattgc 9060
atagtgattg accggcgccg gcgcctgctc ttcggtgata ggtgaatgcg ctgcattgcc 9120
atacacattc gcactgcttg ccagcagtac gctgcgcggc gtcacggaca agccagccag 9180
cgcatccaac aggttcaggg taccgatcac attgacgtca taaaaggcac taacatccgc 9240
atgaccaaca aaactgatcg ctgccagatg aaccactgct tccggacgag ccgcctcaac 9300
ttcgcgttgc aatacagcct tgtccgtcaa atcggccctc agtgcaacaa cctcatggcc 9360
ggccgctttc gcggccgtca gaaaatggcg cccggtgaat ccatcagcac cagtaagcag 9420
aattctcaaa atgagaaacc ttccgtgttg cggcgcagat cggcctcgac catcatctgg 9480
cagagttgct ccagcgttgt cttcggttcc caacccagct tggccttggc cttggctggg 9540
ctaccgatca gtaggtccac ttccgctgga cggtaaaact tcggattgac ccgaaccact 9600
atcttaccgg ttgcagtatc cacggcaact tcgtcctcgc ccttgccctt gaactcaaca 9660
gcaatgccag cccccttgaa cgccatgctt acaaaatcgc gcacagtctc ggtacgattg 9720
gtcgccagta caaaggtatc cggctcatcc gcctgcagga tgcgccacat gccttccaca 9780
taatccttgg catagcccca atcacgcttt gcatccaagt tacccaactc caggcaatca 9840
agtttcccca gcttgatctt ggccaccgaa tccgtgatct tgcgcgtcac gaactcgcga 9900
ccacgcaacg gactctcatg attgaataaa ataccgctag atccgaagat tccatagctt 9960
tcacgatagt taacagtcat ccagtgcgca tacagcttgg cgacaccata aggactgcgt 10020
ggatagaaag gcgtatcttc cgtttgtgga atcgcctgca ccttgccgaa catttcggat 10080
gtggatgctt ggtaatagcg aatattggga tttactaaac gaatggcctc caaaagattg 10140
agcgcaccga cacctgtgat ctccgcggta gtaataggtt gctcaaaaga cacgcccaca 10200
aaactttgcg cagctaagtt gtacacttct gttgcacctg tgctctgcaa tagacggatg 10260
cttgctgaca aatcggtcag gtcgtattca accaaaagaa gatttgggtc attttcaatt 10320
cccagctctt caatacgcca gaagttgacc gagcttgtac ggcggaaggt accgtaaacc 10380
ttatagcctt tactaaggag aagttctgcg agatatgcac catcttggcc tgtgatgccg 10440
gtaatgatgg cagtttttat ggtcatcgta ttatgcctta tgtatttaaa gtcttactgt 10500
atatgtatat atggtatgta aataatggat tcgttagaac agcgtctaaa ttatcttatt 10560
attttccttc atcttttttt ggaaactaga cgatttcgat ctcaggaaat gggaagataa 10620
acctgccgcc atcagctaga aagtcctttt cacggcgcag gataccatct ttgaaatgcc 10680
atggaagcac caagaagtag tcgggcttgg cagcgcgcgc ctctttttcc gaaataatgg 10740
gaatatgcgt tcccggagtg actcgtccga atttttcttc gtttacttct gcaatggcag 10800
ggatttcctc agaagtaaag ccacaaaatt gtagtactac attacctttg gcagaagctc 10860
catacccata tatttttttg ccgtcagcta ctaacgaatg aattaagcgc ctgagatcat 10920
cgcgatgacg atatacacgc tcctcaaatt cacgataagg ccttggggta gataatccca 10980
tccggtcttc ttgctcaagc atccaattga tcactgcaag gttaggctta atactcgtat 11040
tagaacgctt ggcagcagtc acggcaaagc tgcctccgtc tctcctggct ggatatgaaa 11100
acttactcct tgcagaatcc acttcaattg gtggtgcggc ttacgcctca gatctatcca 11160
ctccaacaac cgagaccagc gactggggta ttgcttgtag gccttaccca ggttggtgac 11220
aacaatagta cccattaaag ttcatccacc atatcgcccg catgtttgcg gaataaagac 11280
agccccagca ggcacaacac gatagacagc gcaaacactg gccatagact gtaccagtcc 11340
ggccattttg cttgtaccaa tattccttgg aaagcctcca tcaagcgcgc catggggtta 11400
agccgcatat aatcttgtac ccgttctgga agaatgctga ccggatagac aatcggcgta 11460
agccaaaacc agaaactaag cacaatgcca aagaactgac ctacatcgcg gaaaaacaca 11520
ttgagaacgc ccaatataat acccaagcct agagcaaaga cgatcatcag tatcaatacc 11580
gggatcagca ccaaataagg ccaacccgaa aacataccga tcagcagcaa gaacgctgtg 11640
aacaacccaa aaacaatggc aaagttaact agcgcggtgg cggtgacgat gactggcaga 11700
catagacggg ggaaactcag tttcttgagc aagttggcat tatcgatgaa cgtggtctgt 11760
gagcgcccga caatctcagc aaacaagccc caggtgagta tgccagcgca taaatgaatg 11820
ctaaacgcaa aagtactgtc cacgccaggc aaacgagcct tcattacctg cgagaaaatc 11880
actgtgtaca ctacgatcat tgcgaggggg ttcaagaccg tccagactgc gcctagcagc 11940
gaattacggt acttggattg aaactcgcgc ttgacgctgc ccaacacaaa gccgcgataa 12000
agccataagg cttttaacat gctgatcatc aagtgcgtcc gtagatatct tgaaaacgaa 12060
caatatcgtc ttcgcccaaa tattccccgg attgaacttc aataatcacc aggtcaagca 12120
aacctggatt ttcaagacgg tgtttgtgtc ctgctggaat gtaagtagac tcattggcat 12180
taatgagcag ctcgcgctcg ccgttgacaa ctttagctat accgcttact acaacccaat 12240
gctcactacg atgatggtgc atttgcaagc tcaggctggc accaggcttt accttgatgc 12300
atttgatctt aaaattagcg ccttcttcca atacggtgta tgtgccccat ggacggtgta 12360
ccttgcgatg gtaatttgcc gcactatggg actcaagctt gagttgcttc acaacggttt 12420
tgacatcctg agctctggag tgatgagcca caagcagggc atcgggtgta tcgaccacca 12480
gcaggttatc aatacctata ccagccacaa gacgggaatc actttggata tagcaattat 12540
tagcatccac caataaagct tcgccattca ccctattccc acgctcatct gactggacca 12600
actcagccat ggcgctccat gaaccaatgt cgctccagtc aaaatcagct gcgactaccg 12660
ccacttttga agcacgctcc atgacggcat aatctatgga aatatctgga cttgatgcaa 12720
agtgctcctc gcccaataca acaggctcag ttttggagtc actagatgcc agggtctttt 12780
ttgctatctc aagcacttct ggaacatact ccgcaagtgc agcaataatg gtttttgcag 12840
taaaacagaa tatacctgca ttccatgtaa atcgacctaa agcaatatat ttctcagcag 12900
tttccaaatc tggcttttcg acaaatcgaa cgactctacg cgcgcctgag tccccaattg 12960
actctccgcc ttcaatgtag ccataacctg tttcaggcgt gcttggctct acaccaaacg 13020
tgactatcca gccattcacc gccatatctg tcgcaacagt cactgctttt gaaaaaactt 13080
tttgattacc aataagatga tctgccggca tcaccaacag cactacatct tccccatgtt 13140
tcgcagcggc atgtagtgca gcaactgcaa tggcaggagc agtattgcgc cctatcgtct 13200
ctagtaagta gctatgggaa acattagtgt ctgttgcctc atagacatca cgtgtcagga 13260
agtaatattc cttattcgtt actgtgagca cttcgctcac accatccagg caagcagtac 13320
gttgcaaagt cttctgcaga agggttctgc catcaggtaa ttcgataaat ggcttagtta 13380
gagtttcacg agaaaccggc cataatctgg aaccggcccc gccagacata atgacaggaa 13440
gcagcattaa aaaacttttt tataaaattg gctcattata cctaaagagt tttaaatact 13500
gaattaaatt aaatcttgag cattcaatat gaaatctaat tatataaaaa atattgctac 13560
taaaaacaat atttaacaat aaaaaaacat cataaaaatc ataatactaa ataacacaca 13620
tcccaaaaat tttaaaagat tacgcttcaa ccaattcaga atatctcatc ccaagttaaa 13680
ctcttggatt acaagagtat gtttaaacta cgttcatcaa ggagtctcct cac 13733
<210> 177
<211> 26292
<212> DNA
<213> 糖原甲基菌
<400> 177
attgatgctg gttggtctgg gactgctggg ctttgctgca cgtcgtcgcc aagcttaatt 60
aagctgagca cgtaaatgca cgcgcttatc aggcgtgcat ttagtcatgc taagagtaaa 120
tgaataagtc ggcttcatgc cgacttattc attttgggta ttgtgttggt gcctattcct 180
gaagttgtag cacatactgg gaatggcgag cgaaggtgtg acaagacttg tcataaatct 240
atagcagttg cacagtagca tccgcaaggc cattcatgca gtgagtgagt ctgatttagt 300
ccatagggac tattgaaatg agaatgcctg tcatttggcg atttgatttt gtatcatgag 360
cgtatttcaa actaaggcac atgcatgaac agggcatcac tggggccgat aagtagccgt 420
gttattccct tcgcggtcta tatgctattc atggcagggg tagacctgat cggcgcagtt 480
gtgcctgagg gttttgatct gcgatggtta tatggagtca aggttggctt ggttgcctac 540
ttgctttgga cattgcgcaa acactatatc gagcttggtg gcttgtcgtt gcttagtttg 600
aagtcgtggt tgagcgcaat cagcattggt gtgctagtat ttgtcgcttg gattaacctg 660
gatgccccgt ggatgttact gggcgggcca tcgcaaggct tcaatccggg gcagggtgtc 720
gaagcgtgtc tcctaatggt gacaagaatt gtcggtgctg ccctagtagt gcctctgatg 780
gaagagttgt tctggcgttc tttcctgatg cgctggatac aaaatcagga cttcctcaag 840
gtggagccgg ccacggttgg tgctgtggca ttactggttt cttcactact ttttgccata 900
gagcataacc tatggtttgc tggtctggtt gcggggctgg catacggatt gctttacatc 960
cggagcagaa caatatggat gccgatcatc gcgcatgcgg tgaccaacgg tgtattggga 1020
gtttggatta tctataccgg taactggcat tactggtagc cattggggaa gtatttcttt 1080
gcgactaaca gactctactc attataaaaa gctggttatc acggcagtca taggttggaa 1140
tgcagtgggt tattccgacc ctgtgctggc tcgtgaaggt gatgtcatac ggccctatgt 1200
cagtgcaaca tatgtttatg atgacaacct gaggcgccgc tctgacaagg agtccgatac 1260
gagtgtagtg ggccgggttg gcattattct ggataaggat attagtcagc agaatttcta 1320
cgccaatatc ggtgtgaatg aaaccaaata caacaaaaat tcagagttag acaatacagg 1380
taaagatatt gtcgctcgat ggaactgggc agtgggctcg caattccggg gcaaggttga 1440
gtactataaa aacgaggcta tgctgccttt tgcggatttt cgtggtgtgg aattgaatat 1500
gcgtattcag gagcgtaaaa cttttgaagc aaactggcgt ttccattcca gttggcgcgc 1560
gcgctttggt gtgcagcgcc aggatgttga gtatgactct caaacattga atgcggcttc 1620
ttttcaggaa aattcccagc acgtaggttt ggactattta gctgagtcag gcagtaaggt 1680
tggcttggtc ttcactaatg ggcgtggcac gcggcccttt gataggcctg cttttttccc 1740
ggggattggt accgtgtttg tcaataatga ctacaggcag caatcactca aggcggacat 1800
actttggctt tattctgcca aaacacgatt tgaatttttg ggggggtatg ttgatcgtaa 1860
acatgacagc ttctcacagc gcgatttttc cggatttaat gcccacggga acatggtgtg 1920
gtccattacc gacaaaacct ctttcaagac agccgcatgg cgcgatgcaa atgctatatc 1980
aatcgtaact gccagctatg tgattgatag tggcgcaagt gcaagcatct cctatagcgc 2040
aacgagtaag atcctgctgt caacttcagc caggtatcaa caactaaaat ttgaaggcga 2100
tatcaccggg caagatcaag gtcgtaccga caagaataag gttttttctt ttggggtaac 2160
gtacagccct cttgaatcgt taagtttcac tactggtcta aatagaagtt tgcgtgactc 2220
aacctcacca attttaaact acaactcgac aagcatttcg cttactggtc gttatgaatt 2280
ctgatggtgt aagataaatg accgtaaatg acatcccttt agtagcgttt ttcaagcagc 2340
tgctcgaccc gctgatcatt cttggtacgc tgtatgtgtt caccctgttg tttggtgagc 2400
cttttaatgg ctactacctg attctggcgt tgctagccta ctttgtttcc tctaatgtct 2460
acgagcgtct ggatctttac cgtacctggc gtagtggcaa gatacttggt tatatccgcg 2520
atattctctt tggctggggt attgtcatcg ctgtgctgat gttcatcggc tatgccgctg 2580
atctatccag tcagtatctg gatgagatga tatatgcctg gtttgccagt gtgccgatga 2640
tatttattgt cacgcatctg gcgatacgca aaattgcctc ggatttgcac aagaatggtg 2700
aagtcaggtc cgtagtgatt atcggtgcca atgatattgg cgtgcgcttg atcaatcgca 2760
tcacggacga cccgtacctg tttatggagg tcaaggggat ctttgacgac agagaggtcg 2820
ccaggcaccc caagggcatg cgtaatctgc ctttgcttgg ttccatgtcg gaaattgcgc 2880
catatgtccg cgccaataat acccagatta ttttcatcag cctgcccatg tcggcgcagc 2940
cacgcatcag gcagttattt gaagaattgc aagacaccac agcatctatt tactttgtgc 3000
cggatatcta tatttttgat ctggtacaag cgcgctttga tgatgtggct ggtgtgcctg 3060
tggtcgctat tcttgagacg ccattcaccg gtttcaacag tttaatcaaa cggactagtg 3120
acattatttt ggcgtcgctt attctattaa tgctgtctcc catcatgctg acactggctc 3180
tggccgtgaa gttgacctcc ccaggcccgg tgattttcaa gcagcgacgt tatgctgaat 3240
ggtgaggaaa tcattgtcta taaattccgc tccatgaaag taatggaaga tggtgacaag 3300
gtagtacagg cgcagaagcg agatcagcga ttgacaccga ttggtggttt cttgcgcaag 3360
aactcactgg atgagctgcc gcagttcatc aatgtgttgc aaggtcagat gagtatcgtg 3420
gggcctagac cgcatgccgt ttctcataat gagcaatatc gcaagctgat tcgtggctat 3480
atgctgcggc acaaggtcaa gcctggaata acaggctggg cgcaggtgaa tggtttacgt 3540
ggtgaaactg ataccttgga caagatggag tcccgtatcg agtatgactt ggattatttg 3600
cgccattggt ccctggcttt tgacttctgg attatcgtca ggacggtgct ggttgtgttc 3660
aaaaaagata acgcctacta ggttgtttaa atagatttga ggagattgga aagtgaataa 3720
cggatttgta actaacttca agcaatccag aaccctgtgt gtcggtgctg tgattgtgct 3780
cgctttcgca ttgtcgggct gtggcgacaa gcatgaatcc aaagccagcc agtctctggt 3840
taaggtcaat ggcaaggaaa tcaccgtaca tcagctgaat caggagctgg gtcgtgccaa 3900
cattcaggag aatcagcgcg agcaggcaac gcagcagatt ctgactgcat tgatagatcg 3960
ccagttactt gaagaagctg cgctcaaggc caaggtggat agggatccaa atgtgatgac 4020
cacgattgaa cgtgcgaaat cacaaatcat tgctcaggca tatctgcaat ccaagttagg 4080
cagtgtcgcc aagccaagca aaacagaaat tgagaatttt tataacgaga atcctcaatt 4140
cttcagcaag cgcagaatgg tggaaatgga tcaattgttg attgatacta aattcgccaa 4200
tgatgaattg aaaacagcac ttggcaaact caagaccttg caggaagtag ccgcatggat 4260
ggatgcccat aatattcagt acgatcaagg tcaggtttca cgcagtgttg ctgaattgcc 4320
gccacagatt tccgagcgcc tcaaggccga ggataagggt aagttgttcg tgatcggcat 4380
gggccctcgc accatgttga tcatgatgaa cgagatcaag gacagcccag tttcacttgc 4440
agaagcaaca ccgcaaattg aaaacaattt gctgaataag gcgcgcaagg aagttgctga 4500
aaatgaagtc aagcgcttga aagccgatgc caagattgag tacatcgata aaaagatgga 4560
aacagcgact gaaaccaagg cagccaaaaa gaagccaagc tctactgagg atgatatcgc 4620
cagtggtgtt agtggcttga aataagtact ccccatcctt aatatcagga cgatagtaaa 4680
atgaaaaaat taatgacatg gtttttcttg ctgatgctga gtctgacgcc ttttgtaacg 4740
catgctgcag aaggtgacat tcttctcggc gctggcgatg tgctgaaaat atcggtgttc 4800
gagcagcctg atctgtcact tgaggtcaga gtgagtgaat caggttccat tacttatccc 4860
ctgataggtg aagtgcgtgt gggtggtggt acggttgccg ccgccgagca aagaattgcc 4920
accatgctgg aaaagggtgg tttccttaag agtgctcacg tcaacatcat cgttgcgcaa 4980
ttgcagagcc ttcaagtctc tattctgggt caagtcaatc gcccgggcag ataccctata 5040
gatagcgcta aaacgctggc ggatgtgctt gccttggctg gtggtgtatc acctgaaggt 5100
ggcgatctga tcacgctggt gcataacgtc gatggtaaag cggtcaggga tcagattgac 5160
cttgctgaca tgatgcgtac tggcgatctc agcaagaaca tccgcgtagc tggtggtgac 5220
atcatttatg ttgaacgttt cgataaattc tatatctatg gtcaggttca acgtgccagc 5280
cattaccgtc tcgaacatga aatgacagta ttgcaagcgc tttctgtagg tggtggctta 5340
agccctcgcg gcacagaaaa aggcgtcaag atcaagcgtc gtgatgctag cggccatatt 5400
gaagtaatca ctgccaaaca tgatgacctc atcaagccca acgatgtgat ctatgtgcag 5460
gaaagtttct tttaatagat tgcagatttt aataaatact tgataggcaa ggttaatcta 5520
atgagctttt ctcaactttt actgatattc aaagcgcgat ataagatatt gttaagcacc 5580
attgttgtgg ccctggtcgt agcaattgcg ctcaatattt tcttgccaaa cagctataag 5640
gcaaccacca gtatcctagt caactataaa ggtgtagatc ctgtgactgg tatggctgtc 5700
cctgcccagc tgcttccagg ttatatgggt acccaggtgg atatcataac tagcaagaaa 5760
attgctaaga gggttgtgac cacattaaag ctcaatgaaa gtagtgaggt tgtggagagt 5820
ttcaatgact ccacaggtgg tgaaggtgat atcgttgatt ggttggcgga tttgctgatc 5880
tcacgtatcg aagttcaacc tgcgcgcaac agtagtgtgt tgcagctgga gtttgatgga 5940
gccaacccca aatttgctgc tgttgttgct aactcctttg ccgaggaata tatcaaggcc 6000
actatcgaac tcaaggttga gccttcgaaa aaggcggctg aattttatac cgggcaattg 6060
aaggatttgc gtgccgatat tacccgggcg cagcaaaagc tttccgatta ccaacaagat 6120
aaaagcatcg tcagcgttga tgagcgtcta gacattgaac gtgccaagct gaatgaactt 6180
tcctcgcagt tagtgatgtc acaagggcaa actcttgagg cacagtctcg tcagactggt 6240
gcacaaggta gcaatgctta tggatctccg gatgtcgcga gtaatccaat ggttctgcac 6300
ctgaaaacag agattgctag gtctgaatca cgcttcgcgg atatctcaca aaaatatgag 6360
agaaatcacc cactctatca gggggccaaa gctgagcttg acaatctgaa gtctgaatta 6420
agtaagcaaa tccaggcggc taccgtcaat atatcgagca attatagaat ccttaagcaa 6480
cgcgagagtg aaatccgcaa tgccttggct gagcaaaaaa ccaaggtcat gctgttgaac 6540
aaggataggg atgcactgac ggtattgacg cgtgaagtcg agggtgcgca acgcgcttac 6600
gaactcgcga ctcagcgata tactcaaata aatcttgagg gacagtctaa tcaagctgat 6660
gtatccatcc ttaatccagc gacaccacca cttaagccat caagcccgaa aaaaatattg 6720
aacgtggcag ttgcgttggt gctgggtaca atttttggct tgttgtttag tttgttggct 6780
gagctcacta atgagcgaat tcgctcagaa agagtgctgg tagagattgt tggcgcaccg 6840
ctgctgggtg tgatcgacaa aaataaaacc cattccagaa ttcagcgcct gctggctaaa 6900
aaaccctaat ttgtgtggat atagacatga ctaatgatgt ttccaatact agttccattc 6960
cggcattgaa tgctgatttc aatatcggtg gaatgttgct caagatgggt aagattacac 7020
cgcaggatgc ggagcgtatc ctgcgtgtgc agaaggaaag aggcgttcgc tttggtgagg 7080
ctgccgagag tttgggccta gtttcctctg ccgatatcaa ctatgtatta tccaagcagt 7140
ttgcctatcc ctacctgatg gatggtcgcg gcgatttctc cgagaacttg gtcgcggctt 7200
atgatccatt cagtatcaat gtggagaagt atcgcgccat tcgtagccag ctcatgctct 7260
actggtttgc acaagggaaa aagagcctgt cattttccag tgtttacgac aaggacgaca 7320
ccagtgactt ggttgccaat cttggcgtgg ttttctctca actgggagag aaaacactca 7380
tcattgatgc ccatcttgat agcccacggc agaatcgcat ttttaatatc aagagcactg 7440
cgggtttgtc ggatattctg gcaggccggg ttacggatta ctcctcttcc atcactaggc 7500
tagtcgagtt cgagcatctc tccatcttgt cttctggcac cattccacct aatccgcgag 7560
agcttctggg acgtggtttc ctcaagcagt tcatcacggc aattgctaat gactacgatg 7620
ttatcctggt cgatgcacct tcctttgtcc gccactctga accgttgtct gtggcaagtg 7680
ctacggaagg ggtggtgctt cttgccaagc gtcatgtctc caaagccaat gacttgagca 7740
aagtggttga tcagctttcc aagatcaggg tgcctgttgt tggcacggta ttgactgaaa 7800
actaaaatga gcttgaacca gagcattgcg gtcgccagta cccagctaag aaggtaccag 7860
catgtgatac cactgctggt aggcttgctg ttcttatttg tgcccaccta cctgaacctg 7920
acgaacacgg tctggcagat gcaggatcag gcgcatggcc ccttgatcct gatggtggtg 7980
ctgtacctag tctgggtgga caaggaaata ctgctagaca cggcaaactt gagacaaagc 8040
gggcgtggtg tgggcctgtt gctgtttttg tttggcctgt tggtatacat catcgggcgt 8100
tcacaagatt tgctggtgtt tgatgtgggc tcgcagattc cggtattggc tggcttgctg 8160
ttgattttct ataaggccaa aaccctcaag cgcttctggt tccccttgtt cttcttgttc 8220
ttcatgattc cattgccagg ctccatgctg gatgttgtga ccttgccgat gaaggtcgct 8280
gtctcttacg tggccgagca tgtgctgtat tggtttgatt accccatcgc gcgttcgggt 8340
gtgatcattc agattggtca gtatcagttg ctggtggcgg atgcttgtgc aggcatgcat 8400
accttgattt cactggaggc cctgggcctg ctctacctca atatcgtcag gcatgattcc 8460
ctggcccgta acttgttgct ggccttgctg attatcccta tttccttctc agcgaatgtc 8520
atacgcgtga ttgtgttgac cttgatcacc tactatttcg gggatgaagt gggccagggc 8580
tttgtacatg gattcgcggg tattttgtta tttgtcgtgg cattaaccct gattatttca 8640
gtggatagcc tgatccaata ctttgttggc aaacatacac agcgtaaggc tagattgcag 8700
agttgatatg agcgtcagat taatcaatat cctggcagta tgcatggtgg tgagttctgg 8760
cctggcgttg gctttgaccc ctgatcttag ctccgtgcgg gatgatccac atcttgaaag 8820
tttcgtgcct agcagctttg gtcagtggca ggaagtcaaa accaatcagg tgcagatgga 8880
cctgacagtc aggagagatg gcgaacccag catcgataac ccttatgatg aagttctcat 8940
gaggagttat gccaatgaaa agggtcaggt cattatgctg gctcttgcct atggcaaatt 9000
gcagcggcag gaagtcaagg tgcataggcc tgaactgtgc tatacggcgc agggtttctc 9060
catcagaaat cagcaggata ccgcagtgaa tgtgggggca ggcgcaacac ccatcccatc 9120
caaggcgttg gttgcggctt caagacagcg cgaagagctg gtgctttact ggatcaggat 9180
aggcgatatg atcagtaaga gtgcttggga gacccgactt tatattgtgg agcaaggcct 9240
caaacatcaa ctggtagatg ggatactggt cagaacctca cagatattgg gtgaagatga 9300
tgccgagcaa tctttgcagc tacaacaaca gttcctgcac gatctggtgc aagcagtgcc 9360
cagggacaag cgtaaatact tgattccatc ataattttat agccttgtgt ttccattagg 9420
ataatggaga tcgagtaaag gatttgagca taaaagctgg gtatgctagc aaacagccag 9480
caggggaatt aacaacatat cttaataaca gcgcaccagc tctgcggcgc aagtgcgttg 9540
gcatatcctt gggtgttaaa cctaatctgg gatgactttt ttggtctctg caacaacagg 9600
cgcttgagcc atctcgtcaa ataatgggga ttgggtttga agatattatt tctaagtcac 9660
actgccgcag ggggcgaatt tgtagttggc tcacatcaac tatctaaaca attcgccttg 9720
caagggcatg aggttgtcca cctcagtccg ccagtgacac cagcacatct gacactgttg 9780
cagaaaacac cgtttgagcg tgtccggttt aagcgctgga tgaaagcggg tgatgtcatc 9840
aaccacgtga ccgacattat tcctttctca ttaatacctt ggggtattgc cacccgcttg 9900
ggatctggta gcgatatctt tggttacttc ctgaagtttt cagcactcag acaactccgt 9960
aaacatcaat tttctaatcc tgacgtagtg ttgattgatg agcctcgatt aggctatcta 10020
ctcaaatatt tccctaagtc aaagatcgta taccgcccca ctgatattta tcatgaaatc 10080
agaaatgatc ccagtattgt agatgctgaa aaagggttga tatcccaggt acacggcttc 10140
attgcgacat cagagcctgt aagacagcat ttgaatcgcc taggtgttga tgaggtgcta 10200
ttgctgcaga atggtgtaga tctagatcat tacctgaatt ttacaaaatc caaactggat 10260
ttgccgcctg agccaagggc aatttatgct ggagctctgg atcatcgctt tggttttgat 10320
gtgctgaaaa gtgcagccac aaaacaccag aaaatttcat ttttattggc tgggccagta 10380
gaggaaaaat acaaggcggc atttagtgat cttgccaacg tacactttct tggtcatgtg 10440
caatataaag cgttgcccaa tctcttgagt cagtgccaaa ttggtttatt gccgatgtct 10500
gatcatccat ccaaccttgg ccgtagtcct atgaaattgt ttgaatatgc agcagtcgga 10560
cttcccgttg tttctacctc aacaccagag cttgagcgca gatcattacc ctttgtattt 10620
ttggctgaga atgcccagat tttcacagat aaacttggtg atgtttgcaa tgcggatatc 10680
aaaatattgg ctcagcaggc tcgagataat gctaagcatg agtcttgggc aagtaaaacc 10740
atcacaatac tgaactatat ttattcaaag taaagcaatg aacaaaacta ctgaaccaca 10800
agatagtcaa accaatgttc catggtggct atcccctcat ggactatgct taggctttct 10860
tttgcctatg atcttgttga tctggtggtt ggggtcagtg agatcaccaa cattaaccat 10920
acggggttat atatatttaa gttctgaata tatagctctg gctgtgctaa ttgttgtgct 10980
gtcagcaagt gcagcctgga tgggaagctt cgtcaagaca aaagtcagag tgccgccaga 11040
ctctcaggtt aatatggctt tgcgggtatt aggctatgta gcagttgcag catatatata 11100
ctggttcaaa gagctgatta tcaatcctat gaatattatt aatatattta cagggacagg 11160
tttatcaaga caggaaattg gtgcaacgca agggattaca tcacttgtta acttcacccc 11220
aatatttatt tcgatttaca tatatgccag atatatcgcc aaattacctt taagacaaga 11280
tgttgtattg ttgttctatg caattgtttt attgacattg ctgcgggtat ttgcctgggc 11340
agagcgtctg gcattaattg aaattatttt gccatttgcg ttattgataa cgcggcaaca 11400
agtgttcagt aagattaaaa ttttgcaatt cttcattaag gctggtccct tcgcgggatt 11460
gcccttgctg gtgctttact ttggtatggc ggaatacttc cgctcttgga gctctacaac 11520
ttacgccggg aaatcgagtt tttgggattt tgctctaggg cggattgctt catattatta 11580
cacctcgctc aataatggtg cgggaatgct ggctactgtt aactggccaa catatgaatt 11640
cgaaaatgtg ttgaattgga tgcataaatt tccaattttt ggcggcgtgt ttcgttacta 11700
cgtagatttg cacactatga gaatgggtga gtttctcgct cagtatggtg atgaggagtt 11760
caacaaccct tctgggatat tttcagtgat cctggatttg ggcttgccat ttggcattat 11820
ctacttcttt ataaccgcat ttcttgcagg aatcttttat aaaggctatt tgagaggcaa 11880
ttttttaagt gtaatttttt atccgttatt ttttattacg ttattggaaa ttttcagata 11940
tccgtattta ggaacgtccc gagcttttac cgagattatt ggtgtgatta ttgctttctt 12000
tatagttaag ggaaggactg aaaatgatag aaaatcgtag acacctggtt aaatcattat 12060
tcttgatgct attttcatcc tggcttccca aggtcgcctc ggcagcgcct aaggtggtcg 12120
ggggcaatgc agacttcact agagctttag atgacgcgct tgctggacgc acggaagtgc 12180
taagcggtta ttatgaaata agtaatcctt taagattttc actgaagagt ggcaccgtaa 12240
aatttgcacc agattttcag ctgaaattct tgaatgataa attaagtggt ttagtatttt 12300
cgagttgcag tgatttatca ctcattggtg gagatttttc gtacaaaaac cccccagcta 12360
gaagaattgg acatggtggt atttacgagt tctctagatg taccaaagtc atcgttagag 12420
atggatttta ttatgacaca ccaggtacag gtatcatttt taccttatgt gatgattgtg 12480
cagtaattaa agctacggtt tggaattcct gggctgatgg gttgcacttt gcaaattgca 12540
ataactgcat cgccttggat tatcagtcta ccaatacagg ggatgatggg ttggcgtttg 12600
taaactacaa aaaacatccc gatgcagtag gtggttatgc gaacaacatt gttatcaatg 12660
gttcttatgc acgaggaatt gcgattatcg gtcaatctgg tgtgactata gacaagtttg 12720
aaattaggca cacttccgca gaaggattaa agattggaag tgagcaatac tatgacacta 12780
gaattccttc caatgtgaca atcaaaaacg gcattgttga agaggcaggt acttggtgcg 12840
tggcaaaggc aactggcaat ggtttcctag tccaaggtgc taccgataaa attgttgttg 12900
agaatttgac tgtcaatgcc ccacgcgtgc atggaattgt tttcgacagg catggcggta 12960
atgtcaaaat gaaagatatc gtcgtcaaga atacaaaagc aagtggcata accatgatgg 13020
cggataacat cgagttagtg aatggggagt ttttaaatat tggaacaaca cctctttacg 13080
tcaataaagc attaactgct aatttctcca agattaatgt caataccttc ggattcgcag 13140
ataaatcaag ttggcctatt ttctgggctg ttgaagctaa gaatgtgtta attaaccaaa 13200
tgaaagtgga gtccaccacc ttggttagaa ttggtgggaa aaacgttatt tcacatcaga 13260
taactggggt gcagatcagt ggtgtgcagc ttagcggact gctctctgat gggcttaatt 13320
ccaaaacaac atcggcggtt tctgctataa catcaactgc tgttaagttt attgagcagt 13380
ggaattagca agtggatgca ggtgcgagat tgaggatttc atggatcgat gtctgccgtg 13440
gatttgcaat gctgttggtt gtggttgggc ataatcagat attaatgggc caaagtcttt 13500
ctttggtaaa atttatttat ctttttcata tgccactgtt cttttttatt agtggtataa 13560
ccctcaagcc agatcaagga ttaacgtact atttcacgcg ggcgattaat gttattgcgg 13620
tatattttgt attttcattt ttagttcttc cttttgtttt aatgaaaaat ccagatgatg 13680
gtgttttcaa tatagttctt ggtattttgt acggaactgg acatacaata gaagttgctc 13740
ctctctggtt tataccatgt ttatttttct ctattgtttt ggtcggtctc gcattagtta 13800
tttcaaatca ttttaataac actgatcgtg aatcaaatag aagtccgatt tttttccttg 13860
cattattgtt tatcggagtt ggtgtttttc tcattaactc aattcattat tatttaattg 13920
ataatcttgc ttggggtagt ctgaaaaatt caggaatgat ttggagtatt gatatagcaa 13980
taattggtgc tggctttatt cttctaggta tgtacgcaaa ggtatttgtt gataagtaca 14040
aaattactga aatcaaatca atatatctta ttgtatctat tgtttgtgcg attttcgtta 14100
tgttggggtt gtttagtttt ggtgttgacg tcgatttgaa ttttagaaaa attgcgcatt 14160
atcctttggc tatgctctgc atgatcttag gaatattttt cagtattttg ttttcaattt 14220
ttctagataa atatacctac ctatcaacta tcttgagcag tattggtaaa tctacgttat 14280
tgattctttt atttcacaat gcgattcaaa atcatttaat tttcacaatt ggtgattcaa 14340
aaatatatag tgctgtgatc ggcattgtta tcgcaatatt gatacctata gtacttgata 14400
agtttgttgt gaataaatac gaattgttca gaaaaatagt ttacccaaaa ctatctatca 14460
accttgcatc caagataatg gtagggaaaa gattttgatt gtatatatta atggccgatt 14520
tttaggaaga cgcataactg gggttgatcg atacgcaata gaagtattaa aagagttaaa 14580
tacactgatt gcggaaaatc atcccagtgt agctggtgtt gaatataaga ttgttattcc 14640
tcctcgcatc aaaactgact tgcatctaac tcatatacct atagtggctt atggtttttt 14700
tagtgggcat gcgtgggagc aattgtccct actaatgttg agtctgagta gtaagtcaat 14760
ggtattaaat ttatgtaata caggctcaat cttcgtgcgt agtcaaatcg tcgtcattca 14820
cgatgctgca gtggtgagaa ttcctagtac attttcttta gcatttcggg tgtggtacaa 14880
aacactcatg ccagtactcg gcagagtcgc aaagaaaatt gtaacggttt cagaatattc 14940
gaaaaaagac attattaact tttttggtgt acatcctgaa aaagttcaag ttgttggtgc 15000
aggcggcgag catattttgt cgcaacagcc agacgcaggt attcttgaaa aatttcaagt 15060
tcacccgggc tcttatgtgt tggcggttag tagtcatgct ccgcacaaaa atttttcttt 15120
aaccattgaa tctttaaaac tttctaagaa tgcaaatatt ccgtatttga ttgcaggtgg 15180
ggctaatcag aaaatttttg gtgaaaattc ccagttagat tcttctaagg tgacgttgct 15240
gggttatgtc tcggataatg agttgcgcgc gctttatgaa catgcgcttt gttttgtttt 15300
tccatcactt tatgagggct tcggtcttcc tccactggag gcgatgaatt gcggctgccc 15360
cgtacttgca tcaaatgctg catcaattcc agaggtgtgc agtgatgctg cattatattt 15420
ttcaccgcat gatccgcagg agctttcaaa gcttatagat aatgttgctc atgatgccga 15480
tttgagaaag tcgttagtca accaaggctt gaagcgagca aaagattttt cttggaaaaa 15540
ttccgcaata gatattgcac ggatgtgcaa ggagattttc acaataaagt aatagtatta 15600
tctgccaagc tgaatttttc tttataaagt ctaggccagg catgttgatt attaactaga 15660
ttatgactaa taaatatacg aggcattcga gattgcaccc aaaaaaagta gctatcgttg 15720
tggattggct taatgaatat gctggagcag agcgtgttct ggagcagttg gttctttgct 15780
atcctgatgc agacattttt gctgtcattg aattcttacc tgataacctg agaggtttta 15840
ttcagaataa gaaggttacg acaactttta tccaaaactt gcctaaagct aaaacgcatt 15900
atcgcaatta tttgccacta atgcctttag ctattgagca gctcgatctg tctcaatatg 15960
atttgattat ttctagttct cacgccgtgg ccaagggtgt gcttactggg ccagatcaag 16020
tgcatgtaag ttatgtccat tctcccatga gatatgcgtg ggatttgcaa catcaatact 16080
tgcgtgagtc taatttggtt tcaggtttta aatcttggat tgtcaaatgg ttgctacata 16140
aattgcgtat ttgggatcta agaacggcga acggggtaga tgtttttatc gcaaactctt 16200
cttttattgc taaaagaata aagaaggtat atggacgtga ggctagggtt atttatcctc 16260
ctgtagatac caacagtttt gcattccagg aaaagaaaga tgactttttc ttgactgcct 16320
cgagattggt accttacaaa cgagttgact tgattgtgga agccttttcc aaaatcccag 16380
atcagaaatt agttgtcatt ggggatggtc cagacatgtc caaggtgcgt gcaaaagcag 16440
ggccaaatgt tgaaatcctc ggttatcagt ctcatgctgt gttaagagac tacatgcagc 16500
gtgcgaaagg gtttgtcttc gcggcggagg aagattttgg tatttctcct gttgaggcac 16560
aagcatgtgg tactcccgtg attgctttcg ccaaaggtgg cgccttggag acagttattc 16620
cagaagagcg aggtgatcct gccactggtt tgttcttcca tgagcagaca gctgatgcca 16680
tcgtggatgc tattactaga tttaatctac tctctcaaaa gattagtcca tttgcatgca 16740
gagagaacgc actgcgcttt tctcctgatc gatttagaaa tgagattatt tcaactgtga 16800
ataaggctct cgattaatta ttttctctta cgacatatag taagttctca tatttaattt 16860
tataggatag ttgctatgaa aatagctgtt gcaggtactg ggtatgtggg cttgtcgatt 16920
gctgtgcttt tagcacagaa aaatgaagtt gttgctcttg atatcgtccc tgataaagtt 16980
gaccttatca acaataaaat ttctccaatc gttgataaag agattgagca ttatcttaag 17040
aatattccat tgaacctacg tgcgactaca aacaagcatg atgcatatga aaatgcagat 17100
tttgtagtga ttgcaacccc tacggactat gatccggtta ccagctactt caatacctcc 17160
tctgtagagg cagtgatcaa ggatgtccag gcgattgcgc ccaacgcgac catggtgatc 17220
aaatccacca tccctgttgg ttataccaaa atgatttccg aaaagttggg tgtggataac 17280
ctgattttct ctcctgaatt cttgcgtgaa ggtaaggcac tttacgacaa cctgtatccc 17340
tcgcgtatcg tcattggtga aatttcggat cgcgcacaag tttttgccga ccttctcaat 17400
gcaggtgctg tgaaagagaa tattccggtg ctattgacca atagtgctga agcggaggcc 17460
attaagctgt ttgccaacac cttcctcgcc atgcgcgtcg cctatttcaa tgagctggat 17520
acttatgccg ccacccatgg cctgaacaca cgtcagatca tagatggggt gtgcctagac 17580
ccacgtgtcg gtgaccacta taacaatcca tcgtttggct atggtggtta ctgcctgcct 17640
aaggatacca agcaactgct ggccaattac gacaacgtgc cgcaaaaact catcaatgcc 17700
attgttgatg ccaacaccac gcgcaaggat ttcatcgccc agagcatcat caagcgtgac 17760
cccaaggtgg tgggtatcta ccgcctgatc atgaaagcag gctcggataa cttccgcgcc 17820
agttcaatcc agggcgtgat gaagcgcatc aaggcacgtg gtattaaggt cgtggtgttt 17880
gagcctgagt tgaaagaaga tcaattcttc aattcagagg tgatccgcaa tctggaagag 17940
ttcaagaaga tttcagacgt cattgtcgcc aatagaaggg cgcaggattt gtcagacgtt 18000
gatgagaaag tatatacgcg tgatttgttt ggcaatgact agccagattg aaaaggtgtt 18060
gggttaagga tatgaggata cttttttcac ctgctacggc gagtaatcag tatgtcgaga 18120
acacgattgc cctgattaaa accctagacg ctacccatgt cgaaacccaa gccagattga 18180
atgctggatt catcttgcgc aatgctttca accgctatga ttgcattatc atcaactggc 18240
tggaaaacaa cctggttgga aaaaacaagt cgcttgatat atgggcggta gcaaaatttc 18300
tgttcaagtt tttcatctac agagtcatgg ggagaaagtt gatttttgtc aggcacaata 18360
tttatcctca tgccttgaag ggtcggcagg catccatcgc gacctggatc attgaagcgg 18420
cgattaagct ctcaacaata tccgttgtac attcagggca tctcgaaaat gagaacgcga 18480
aatatgtacc tcatcctttg tacagggttg attcgcaggt tgaaggccaa ggcagtgatt 18540
attatgtaat ttttggcagg attgttgcgt ataaagccat ccataaatta ctcgaaagct 18600
gggggtcgca gcggctaatc atagccggca ttgtcgagga tcatgcctac gctgccagct 18660
tgcaatccat catacagtcc agagggttga gcaatgttga actgcgtgct gaattcctct 18720
ccgaagccga ggctgaacaa ctggtagcta acagcaaggg cttgattctt tcacattgcg 18780
atgccgacat gattgtcagt ggtagttttt tctttgctgc aagtctgggc gtgcctgttt 18840
ttgccatgga tactccattt ttccagtggc tgaagaatga gcaaggctat cagggcttgc 18900
aggtgttcac atcactgcag gcaatgacgg ctgagctagc cactgccgcg gccgtggaaa 18960
aaaatactat tgctgcttca gcccagcgtt tatttggcaa tgatagggtg agaagtgcat 19020
ggggtagtgt gctccatggt taattcaata ccttatcttt tgtctcactt aatattttga 19080
ttgaattgca acaatgagca aattgatgac cacgataggt caggatgtta accagcctgc 19140
aggcattcct gaagtattta caatcaatga tgtcgttgac agagggctat gcgttggatg 19200
tggtgcgtgc gcggttgtag attcaaacgt caagctaacg cgcaatcaat atggttccat 19260
ggtggccgcc attgatgcca atatcctgcc agggtctatt gccgaccggg tatgcccatt 19320
ttctgataac agtcttaatg aagatgttgt gggagaacgg gtttttgcga gttgtgaaaa 19380
ttttgatcaa cgtaccggtt attacaccaa tttatattat ggccgcaggt tcactgaagc 19440
tgaattgctg aaaagcagtt ctggtgggct gaccagttat gtcgccattg aacttctcaa 19500
gcgtcatcac gtggatggca ttattcatgt gggacgcgac cagtcagatg atcgcgatgc 19560
tttgttcaag ttcatggtgt cttacacaga agaagacgcc aatgcctgca agaaatcaca 19620
atattattcc ctgagttttg atgaggtagt aagaagcata cgcggagatg gtaagcgtta 19680
tgtatttgtg ggcgtgccct gctttgtcaa atctctgaga aatatttgtc tcaatgatgc 19740
tgtgctcaat gagcagattc cattcatgct gggcttggtg tgtggtcatt tgaagtcttc 19800
gcgctttgcc gaattactag cgtggcaact tagtgtgcca ccggaaaaaa tccagagtgt 19860
ggactttaga gtaaaaaata atgcctccac cgtgaattcc tacgatttcc aggtggtgga 19920
tagcaatcag caagcccatg caaaaacctc taatacaatg ctgggcggca attggggcca 19980
tgcggcgttt caacttcagg catgcgatta ttgtgatgat atatttgccg agacagcaga 20040
cgctgtcttt ggtgatgcat ggttgccgca gttctccaca tggtggcaag gtaccaatat 20100
cgtcctggta agaaacccta tcatcgacga cattctggaa tcggggaaaa atgcaggcgc 20160
catcactctg ggcggtgtca gcattgatga tttatgcaag tcgcagttgg gtaatttccg 20220
ccacagaaaa gatggtttga ttgtcaggtt agacgatgac ctgaagcagg gcaagaaggt 20280
ccccaaaaaa cgggttgatc tgtctgcatt aggcaagatt gaccagaaga gaaagaaaat 20340
tgtcaggctc agaaaggaaa tggccgtgaa aagtcacgaa tatttcctgc aggcccgaga 20400
aaagcacgat ctcagccttt atatgaagcc catggggcag ttggcgagaa atatgcttaa 20460
gctgtatagg gatccattta tgaagcgact gatcaatagg ctgaagcgat atttttaata 20520
ttgccttagg tcaatgcgtt atcactcatt aatctaattt ttgaatggtc tagggatttg 20580
agtctatctg taaaagccgc gcgcggtggt gtggtcatga tgtcaggaca aattgtgaag 20640
gtagctttgc agtttggcag cctgattatc ttggcacgcc tgttgcaacc agaagatttt 20700
ggtttggttg ccatggtgat tgcgatttat ggcatttgcg acatcttgct cgactttggc 20760
ctttcgacgg cgtctattca agtccaaaac ataactaaag cgcagatcag caacctgttc 20820
tgggtcaatg tattgatagg tctgttgttt acgctgattt catacttttc agcaagttta 20880
ctggcgagct tttatgctca gccagaatta accaaaattg cgcagtatgt ttctgtggtg 20940
tttttattca atggtattgc cgcacaatat aaagcccagc tgaaccgtaa tttcaaattc 21000
aaacagatgg caataacaga tacgactgct gttttgctca gtgtttgtat cggggtctat 21060
ttcgcatatg ccggacattc ttactgggcc atcgtatatc agcagatagc gcaggcattg 21120
atacaaatgc ttttgtacat gcttttcggc gcttggctac cttccttgcc ttcaagacat 21180
gtttctatca gacatttctt caaattcggt tgggggctgg ctggttctca attgatggga 21240
tacttctcgc gcaatattcc agctatcttg attggtaatc aaataggtgc cagccagttg 21300
gggttttacg atagagccaa caaattactg atgttgccgc taaaccagct gaatgcgcct 21360
tcatcgtcgg ttgctgtccc tgtgttgtca cgtttggcag tggaagatca ggaaaaatac 21420
aatcgttttc ttctgtttgg acaaaatatc attgtccatc tcgttgtatt ttgcctggcc 21480
ttaacctgct gccagacaga gcgcctggtg caattggtgc tcgggacaca atggttggaa 21540
atggtgccgg tctaccgggc actttcattt gcagggatat ttttggcgct cagctatgcc 21600
agttactggg tatttttatc taaagggatt actgcctctc tatttaaact aggcttggtt 21660
agcaggccaa tctctatttt gattatttgc ctggggctgc ccgctggtgt gattggcgta 21720
gcgtatgcat actcggcaag tctgctcttt acctggctac tcggcgtttt ctggctgagg 21780
aaaacgggcg ttcctgtcaa aagcatgatt gtagatccac tcatcatgtc tgccatttac 21840
tatagcgcca gttttatcgc caattacgtg gtcgatcatt atgtggactt tgccatatac 21900
aacattcttg tcggctggtt gctgatgttg ctgatcctgg cagtatttta tttgttggtc 21960
cccaagttca aacgtagcgt gaaaaagtta tttgaagtga aaagttatat tcggaacaaa 22020
caatgaagac cattaaaaaa ttactataca aaatcctagg tagtgcaggc atcaaggcca 22080
aggctgcagc agtcatcaat ctcctgtttg gtcgtgtggc tagaagcact aatgacagtg 22140
tctctattct tattccggca ccaggagggg ggaatatcgg tgatcaggca atgctggaat 22200
catttttgca taatattgat ggcaaaaaac tcattatcaa aacacagcct atagcattgg 22260
atattcctag tcactatgca gtgaacgttg aagtgatcga aatgccagga ttgatctacg 22320
gtcatttgtt caggtttttg cgggattacg taagactgag aaaaataatg gcatctgcca 22380
gcgctttgta tgtagttggc gcagatatca tggatggtgg ctataataaa aatgcctcta 22440
tcatgcgctc taaaattgca acttatttcg cgcgtaataa tattccatcc agggtgtttg 22500
gtttcagttg gaatggcaat cctgatgcag cagcgctttc tgctatcaga aacgcagctg 22560
ccaatggggt tttgctttgt gcgcgagatc ctctttcatt ccagcgtcta caagatgcag 22620
gggttcccaa tatcaggctg gttgcagata tggtgtttgc caatgacaac accaaatcag 22680
ctgggattga agatattttg caattctgcg caggcaagca gattgctctg gtaaatgcca 22740
gtggattgat tggcaaaaat attgatcaaa ttgatgaata tagcaaggta ataaacaagc 22800
tgatggacca caattttaat attgtactat tgcctcacgt gatcagacac ggagccaatg 22860
acttgccgat ttgtcaggca ttgtcaggca agtatccgaa tgctttccta gtaaatagac 22920
tgttggaacc agatcaggtt aagcgcttag cacaagaggc taaaattgtc gtcaccggtc 22980
gcatgcatct ttccatcatg agcctgaatc agaatgttcc atctatcgta ttatcgaccc 23040
aaggcaaggt tgatgggctt atgcaattct tcgaaactga aaaactgtcg attaatccgg 23100
aaaaaggttt ttccgatctt atttgttcac aaattgattt tatttgttct aatcggcaat 23160
attatcaaga cctgattcgt aaaaacctac ttaaggttaa ggaactggcc gctgggaatt 23220
ttaattagtg tgataattat gacttatcat cgggctgctt tcagggtgca aaatagttag 23280
attccccagt taatattcta taataatgtt tatatgtatt aatggttttc attgcatttt 23340
atatctatga tatatgcaca ctaatgttgg tgtaattttc aatatttatt gattagcagg 23400
cacatcataa tttattgcaa gcttttacta taatgatagt gatgaactgt cgaagtgttt 23460
tggattatgt tcacactatg tctccaggga ttatatgtct aaattctata aatttcaggt 23520
gttagaatca ctaagaggtt atatggcatg gtgggttgtt ttaggtcatg ctatccaact 23580
ttctggtttt tggcacaagc aagaagtaga tgagtttttt acaggagggg gcataattaa 23640
tgccactttt tcaaaaatac tcagtttaat catcaatcca gaacttgcag tcaacatttt 23700
tattatttta agtggttttg tgattactca tttattgctt actaaaaatg agccatattc 23760
acatttcata actagacgat ttttccgctt ggcgcccgca ttttacgttt cgttagttat 23820
cgcgattttg gtagttaatt tttacaaggt tgcatatacc ggtctgagtt tttctggtga 23880
tacctcgatg cgactcgcca ggcttgttga gcaagatagt aattttttat tgcatttatt 23940
caatcattta ctcctcattc atagcgtttt cccgcaagag ctgattcaat tttcacctac 24000
cacgtttctt gctccggcat ggagcatcag tcttgagtgg cagttctatc taattgcacc 24060
agtcttaatt ccatttttgg tgaagtctga gaagtctttg attgtttggg ttgtgttgtt 24120
gctactgctg cgatatttta ccaaccatgt tttagacttt aattggcaac atagctcctt 24180
cttctttaaa gctgtcgatt atttcttggt cggcatctta agcagattaa ttatcgagcg 24240
actgcagcat ggcaagttta tttatgatgt tgccgtgttg ctaggtggaa tattgctttt 24300
ccaggataga tattgcgctg ttatctggct gtttgttttg gctgtcatat tttatgaaat 24360
gggttattgg agtgttaaat ctcccctatg gaaaaaaatc ctgacattat ttttctacaa 24420
taaagtcatc acgaatattg gtaagtggtc ttattctact tacctaatcc atattcctat 24480
tttctcaatt ttcttaggtg gttatgcaac tctgactgac cctggcactg taacccagca 24540
aatttctttg attatcctat ttgtcagttt tccagtggtt ttgctgattt caaatattat 24600
gtatcacaac atagagctgc catcgatgaa ttatatttcc gcaaaactaa aagaaaaacg 24660
tatcactgaa tctgcagagt gatggttaat tctcttattg catgctggaa taattattct 24720
ttcaatgtga gtgccatatt tttttaatgt tattaattta tcgttttaga gattttaatt 24780
atattttcta tttgattttt taatgcaaga tttttatcta ttaaacaatt aattattgat 24840
tggaatgaaa aatgaaaatt gttcctgtat tactctccgg tggttctggt acacggttat 24900
ggccactttc tcgagcggta ttacctaagc aactgttgcc cttgatcact aataaaacca 24960
tgctgcagga gacccttctc agaatttcaa gatgggcgac tgtaacaaat ccagttgttg 25020
tttgcggtaa cgatcatcga ttcttagtgg ctgaacagtt gcgcgaaatc gctttgagtc 25080
ctaactctat tattctagag cctgccccca agaatactgc accagctatt gccgctgcag 25140
cattgcagct acaaggtcag gatgtttata tgctggtctt gcctgctgat catgtcatca 25200
gggatctgca aagttttgaa catgctgtgc aaaccgcatt gactgccgct gatcaaggta 25260
acttagtcac cttcggtatc aaacctgctc atcctgaaac cggttatggc tacatcaaat 25320
taggcgttga gagcgcacca ggatcttata aggtcaatcg ttttgttgag aagccagatc 25380
ttgccacagc aactgaatat gtggcgtcag gtgagttttt ctggaacagt ggcatgtttt 25440
tattcaagcc agaaactttc ctcaagcaac tggaaatcca tgcccccgaa attactgctg 25500
cagtaagcaa ggccgtcaat aacagttata aggatctgga tttcgtcaga ttagaagaat 25560
cgagttttgc tgagtctccg tccttatcca tcgattatgc ggtaatggaa aaaaccgatc 25620
atgctgttgt agtgcctgct gatattggtt ggagtgacgt tggctcatgg acgtctctac 25680
aagaggtgca agagcaggat gccaatggca atgtagctcg tggcgatgtt tacctcaaga 25740
atgtcgagaa cagtctggtg cggagtgagg ataggtttgt tgccgcgatt ggtgtccgtg 25800
atctgatcgt ggtggagacc agtgatgccg ttctggtagc tagcaaggat gctgcacaag 25860
atgtcaagga ggtagtggaa tacctcaagt taaatcaacg ctctgagcac aagatacatc 25920
cacgggccta caggccttgg ggttggtatg aaagtattga tctgggcgag cgccaccagg 25980
tgaaacgtat catggtgaag ccgggcgaaa agctgtccct gcaaatgcac caccatcgtg 26040
ccgagcattg ggttgtagtc agtggttcag ccatgattac ggtggatggg aataccaagc 26100
tattcagtga aaatcagtca acgtacattc caattggctc cacccataga ttggagaatc 26160
cgggcaagtt gccgctgcac ttgatcgagg ttcagtccgg aagttatctg ggcgaagatg 26220
acattgtgcg ttacgaggat acctacggcc ggtcctgata agaaaagcgt cgtcctcagg 26280
ctagtgtcat gc 26292
<210> 178
<211> 26292
<212> DNA
<213> 糖原甲基菌
<400> 178
gcatgacact agcctgagga cgacgctttt cttatcagga ccggccgtag gtatcctcgt 60
aacgcacaat gtcatcttcg cccagataac ttccggactg aacctcgatc aagtgcagcg 120
gcaacttgcc cggattctcc aatctatggg tggagccaat tggaatgtac gttgactgat 180
tttcactgaa tagcttggta ttcccatcca ccgtaatcat ggctgaacca ctgactacaa 240
cccaatgctc ggcacgatgg tggtgcattt gcagggacag cttttcgccc ggcttcacca 300
tgatacgttt cacctggtgg cgctcgccca gatcaatact ttcataccaa ccccaaggcc 360
tgtaggcccg tggatgtatc ttgtgctcag agcgttgatt taacttgagg tattccacta 420
cctccttgac atcttgtgca gcatccttgc tagctaccag aacggcatca ctggtctcca 480
ccacgatcag atcacggaca ccaatcgcgg caacaaacct atcctcactc cgcaccagac 540
tgttctcgac attcttgagg taaacatcgc cacgagctac attgccattg gcatcctgct 600
cttgcacctc ttgtagagac gtccatgagc caacgtcact ccaaccaata tcagcaggca 660
ctacaacagc atgatcggtt ttttccatta ccgcataatc gatggataag gacggagact 720
cagcaaaact cgattcttct aatctgacga aatccagatc cttataactg ttattgacgg 780
ccttgcttac tgcagcagta atttcggggg catggatttc cagttgcttg aggaaagttt 840
ctggcttgaa taaaaacatg ccactgttcc agaaaaactc acctgacgcc acatattcag 900
ttgctgtggc aagatctggc ttctcaacaa aacgattgac cttataagat cctggtgcgc 960
tctcaacgcc taatttgatg tagccataac cggtttcagg atgagcaggt ttgataccga 1020
aggtgactaa gttaccttga tcagcggcag tcaatgcggt ttgcacagca tgttcaaaac 1080
tttgcagatc cctgatgaca tgatcagcag gcaagaccag catataaaca tcctgacctt 1140
gtagctgcaa tgctgcagcg gcaatagctg gtgcagtatt cttgggggca ggctctagaa 1200
taatagagtt aggactcaaa gcgatttcgc gcaactgttc agccactaag aatcgatgat 1260
cgttaccgca aacaacaact ggatttgtta cagtcgccca tcttgaaatt ctgagaaggg 1320
tctcctgcag catggtttta ttagtgatca agggcaacag ttgcttaggt aataccgctc 1380
gagaaagtgg ccataaccgt gtaccagaac caccggagag taatacagga acaattttca 1440
tttttcattc caatcaataa ttaattgttt aatagataaa aatcttgcat taaaaaatca 1500
aatagaaaat ataattaaaa tctctaaaac gataaattaa taacattaaa aaaatatggc 1560
actcacattg aaagaataat tattccagca tgcaataaga gaattaacca tcactctgca 1620
gattcagtga tacgtttttc ttttagtttt gcggaaatat aattcatcga tggcagctct 1680
atgttgtgat acataatatt tgaaatcagc aaaaccactg gaaaactgac aaataggata 1740
atcaaagaaa tttgctgggt tacagtgcca gggtcagtca gagttgcata accacctaag 1800
aaaattgaga aaataggaat atggattagg taagtagaat aagaccactt accaatattc 1860
gtgatgactt tattgtagaa aaataatgtc aggatttttt tccatagggg agatttaaca 1920
ctccaataac ccatttcata aaatatgaca gccaaaacaa acagccagat aacagcgcaa 1980
tatctatcct ggaaaagcaa tattccacct agcaacacgg caacatcata aataaacttg 2040
ccatgctgca gtcgctcgat aattaatctg cttaagatgc cgaccaagaa ataatcgaca 2100
gctttaaaga agaaggagct atgttgccaa ttaaagtcta aaacatggtt ggtaaaatat 2160
cgcagcagta gcaacaacac aacccaaaca atcaaagact tctcagactt caccaaaaat 2220
ggaattaaga ctggtgcaat tagatagaac tgccactcaa gactgatgct ccatgccgga 2280
gcaagaaacg tggtaggtga aaattgaatc agctcttgcg ggaaaacgct atgaatgagg 2340
agtaaatgat tgaataaatg caataaaaaa ttactatctt gctcaacaag cctggcgagt 2400
cgcatcgagg tatcaccaga aaaactcaga ccggtatatg caaccttgta aaaattaact 2460
accaaaatcg cgataactaa cgaaacgtaa aatgcgggcg ccaagcggaa aaatcgtcta 2520
gttatgaaat gtgaatatgg ctcattttta gtaagcaata aatgagtaat cacaaaacca 2580
cttaaaataa taaaaatgtt gactgcaagt tctggattga tgattaaact gagtattttt 2640
gaaaaagtgg cattaattat gccccctcct gtaaaaaact catctacttc ttgcttgtgc 2700
caaaaaccag aaagttggat agcatgacct aaaacaaccc accatgccat ataacctctt 2760
agtgattcta acacctgaaa tttatagaat ttagacatat aatccctgga gacatagtgt 2820
gaacataatc caaaacactt cgacagttca tcactatcat tatagtaaaa gcttgcaata 2880
aattatgatg tgcctgctaa tcaataaata ttgaaaatta caccaacatt agtgtgcata 2940
tatcatagat ataaaatgca atgaaaacca ttaatacata taaacattat tatagaatat 3000
taactgggga atctaactat tttgcaccct gaaagcagcc cgatgataag tcataattat 3060
cacactaatt aaaattccca gcggccagtt ccttaacctt aagtaggttt ttacgaatca 3120
ggtcttgata atattgccga ttagaacaaa taaaatcaat ttgtgaacaa ataagatcgg 3180
aaaaaccttt ttccggatta atcgacagtt tttcagtttc gaagaattgc ataagcccat 3240
caaccttgcc ttgggtcgat aatacgatag atggaacatt ctgattcagg ctcatgatgg 3300
aaagatgcat gcgaccggtg acgacaattt tagcctcttg tgctaagcgc ttaacctgat 3360
ctggttccaa cagtctattt actaggaaag cattcggata cttgcctgac aatgcctgac 3420
aaatcggcaa gtcattggct ccgtgtctga tcacgtgagg caatagtaca atattaaaat 3480
tgtggtccat cagcttgttt attaccttgc tatattcatc aatttgatca atatttttgc 3540
caatcaatcc actggcattt accagagcaa tctgcttgcc tgcgcagaat tgcaaaatat 3600
cttcaatccc agctgatttg gtgttgtcat tggcaaacac catatctgca accagcctga 3660
tattgggaac ccctgcatct tgtagacgct ggaatgaaag aggatctcgc gcacaaagca 3720
aaaccccatt ggcagctgcg tttctgatag cagaaagcgc tgctgcatca ggattgccat 3780
tccaactgaa accaaacacc ctggatggaa tattattacg cgcgaaataa gttgcaattt 3840
tagagcgcat gatagaggca tttttattat agccaccatc catgatatct gcgccaacta 3900
catacaaagc gctggcagat gccattattt ttctcagtct tacgtaatcc cgcaaaaacc 3960
tgaacaaatg accgtagatc aatcctggca tttcgatcac ttcaacgttc actgcatagt 4020
gactaggaat atccaatgct ataggctgtg ttttgataat gagttttttg ccatcaatat 4080
tatgcaaaaa tgattccagc attgcctgat caccgatatt cccccctcct ggtgccggaa 4140
taagaataga gacactgtca ttagtgcttc tagccacacg accaaacagg agattgatga 4200
ctgctgcagc cttggccttg atgcctgcac tacctaggat tttgtatagt aattttttaa 4260
tggtcttcat tgtttgttcc gaatataact tttcacttca aataactttt tcacgctacg 4320
tttgaacttg gggaccaaca aataaaatac tgccaggatc agcaacatca gcaaccagcc 4380
gacaagaatg ttgtatatgg caaagtccac ataatgatcg accacgtaat tggcgataaa 4440
actggcgcta tagtaaatgg cagacatgat gagtggatct acaatcatgc ttttgacagg 4500
aacgcccgtt ttcctcagcc agaaaacgcc gagtagccag gtaaagagca gacttgccga 4560
gtatgcatac gctacgccaa tcacaccagc gggcagcccc aggcaaataa tcaaaataga 4620
gattggcctg ctaaccaagc ctagtttaaa tagagaggca gtaatccctt tagataaaaa 4680
tacccagtaa ctggcatagc tgagcgccaa aaatatccct gcaaatgaaa gtgcccggta 4740
gaccggcacc atttccaacc attgtgtccc gagcaccaat tgcaccaggc gctctgtctg 4800
gcagcaggtt aaggccaggc aaaatacaac gagatggaca atgatatttt gtccaaacag 4860
aagaaaacga ttgtattttt cctgatcttc cactgccaaa cgtgacaaca cagggacagc 4920
aaccgacgat gaaggcgcat tcagctggtt tagcggcaac atcagtaatt tgttggctct 4980
atcgtaaaac cccaactggc tggcacctat ttgattacca atcaagatag ctggaatatt 5040
gcgcgagaag tatcccatca attgagaacc agccagcccc caaccgaatt tgaagaaatg 5100
tctgatagaa acatgtcttg aaggcaagga aggtagccaa gcgccgaaaa gcatgtacaa 5160
aagcatttgt atcaatgcct gcgctatctg ctgatatacg atggcccagt aagaatgtcc 5220
ggcatatgcg aaatagaccc cgatacaaac actgagcaaa acagcagtcg tatctgttat 5280
tgccatctgt ttgaatttga aattacggtt cagctgggct ttatattgtg cggcaatacc 5340
attgaataaa aacaccacag aaacatactg cgcaattttg gttaattctg gctgagcata 5400
aaagctcgcc agtaaacttg ctgaaaagta tgaaatcagc gtaaacaaca gacctatcaa 5460
tacattgacc cagaacaggt tgctgatctg cgctttagtt atgttttgga cttgaataga 5520
cgccgtcgaa aggccaaagt cgagcaagat gtcgcaaatg ccataaatcg caatcaccat 5580
ggcaaccaaa ccaaaatctt ctggttgcaa caggcgtgcc aagataatca ggctgccaaa 5640
ctgcaaagct accttcacaa tttgtcctga catcatgacc acaccaccgc gcgcggcttt 5700
tacagataga ctcaaatccc tagaccattc aaaaattaga ttaatgagtg ataacgcatt 5760
gacctaaggc aatattaaaa atatcgcttc agcctattga tcagtcgctt cataaatgga 5820
tccctataca gcttaagcat atttctcgcc aactgcccca tgggcttcat ataaaggctg 5880
agatcgtgct tttctcgggc ctgcaggaaa tattcgtgac ttttcacggc catttccttt 5940
ctgagcctga caattttctt tctcttctgg tcaatcttgc ctaatgcaga cagatcaacc 6000
cgttttttgg ggaccttctt gccctgcttc aggtcatcgt ctaacctgac aatcaaacca 6060
tcttttctgt ggcggaaatt acccaactgc gacttgcata aatcatcaat gctgacaccg 6120
cccagagtga tggcgcctgc atttttcccc gattccagaa tgtcgtcgat gatagggttt 6180
cttaccagga cgatattggt accttgccac catgtggaga actgcggcaa ccatgcatca 6240
ccaaagacag cgtctgctgt ctcggcaaat atatcatcac aataatcgca tgcctgaagt 6300
tgaaacgccg catggcccca attgccgccc agcattgtat tagaggtttt tgcatgggct 6360
tgctgattgc tatccaccac ctggaaatcg taggaattca cggtggaggc attatttttt 6420
actctaaagt ccacactctg gattttttcc ggtggcacac taagttgcca cgctagtaat 6480
tcggcaaagc gcgaagactt caaatgacca cacaccaagc ccagcatgaa tggaatctgc 6540
tcattgagca cagcatcatt gagacaaata tttctcagag atttgacaaa gcagggcacg 6600
cccacaaata cataacgctt accatctccg cgtatgcttc ttactacctc atcaaaactc 6660
agggaataat attgtgattt cttgcaggca ttggcgtctt cttctgtgta agacaccatg 6720
aacttgaaca aagcatcgcg atcatctgac tggtcgcgtc ccacatgaat aatgccatcc 6780
acgtgatgac gcttgagaag ttcaatggcg acataactgg tcagcccacc agaactgctt 6840
ttcagcaatt cagcttcagt gaacctgcgg ccataatata aattggtgta ataaccggta 6900
cgttgatcaa aattttcaca actcgcaaaa acccgttctc ccacaacatc ttcattaaga 6960
ctgttatcag aaaatgggca tacccggtcg gcaatagacc ctggcaggat attggcatca 7020
atggcggcca ccatggaacc atattgattg cgcgttagct tgacgtttga atctacaacc 7080
gcgcacgcac cacatccaac gcatagccct ctgtcaacga catcattgat tgtaaatact 7140
tcaggaatgc ctgcaggctg gttaacatcc tgacctatcg tggtcatcaa tttgctcatt 7200
gttgcaattc aatcaaaata ttaagtgaga caaaagataa ggtattgaat taaccatgga 7260
gcacactacc ccatgcactt ctcaccctat cattgccaaa taaacgctgg gctgaagcag 7320
caatagtatt tttttccacg gccgcggcag tggctagctc agccgtcatt gcctgcagtg 7380
atgtgaacac ctgcaagccc tgatagcctt gctcattctt cagccactgg aaaaatggag 7440
tatccatggc aaaaacaggc acgcccagac ttgcagcaaa gaaaaaacta ccactgacaa 7500
tcatgtcggc atcgcaatgt gaaagaatca agcccttgct gttagctacc agttgttcag 7560
cctcggcttc ggagaggaat tcagcacgca gttcaacatt gctcaaccct ctggactgta 7620
tgatggattg caagctggca gcgtaggcat gatcctcgac aatgccggct atgattagcc 7680
gctgcgaccc ccagctttcg agtaatttat ggatggcttt atacgcaaca atcctgccaa 7740
aaattacata ataatcactg ccttggcctt caacctgcga atcaaccctg tacaaaggat 7800
gaggtacata tttcgcgttc tcattttcga gatgccctga atgtacaacg gatattgttg 7860
agagcttaat cgccgcttca atgatccagg tcgcgatgga tgcctgccga cccttcaagg 7920
catgaggata aatattgtgc ctgacaaaaa tcaactttct ccccatgact ctgtagatga 7980
aaaacttgaa cagaaatttt gctaccgccc atatatcaag cgacttgttt tttccaacca 8040
ggttgttttc cagccagttg atgataatgc aatcatagcg gttgaaagca ttgcgcaaga 8100
tgaatccagc attcaatctg gcttgggttt cgacatgggt agcgtctagg gttttaatca 8160
gggcaatcgt gttctcgaca tactgattac tcgccgtagc aggtgaaaaa agtatcctca 8220
tatccttaac ccaacacctt ttcaatctgg ctagtcattg ccaaacaaat cacgcgtata 8280
tactttctca tcaacgtctg acaaatcctg cgcccttcta ttggcgacaa tgacgtctga 8340
aatcttcttg aactcttcca gattgcggat cacctctgaa ttgaagaatt gatcttcttt 8400
caactcaggc tcaaacacca cgaccttaat accacgtgcc ttgatgcgct tcatcacgcc 8460
ctggattgaa ctggcgcgga agttatccga gcctgctttc atgatcaggc ggtagatacc 8520
caccaccttg gggtcacgct tgatgatgct ctgggcgatg aaatccttgc gcgtggtgtt 8580
ggcatcaaca atggcattga tgagtttttg cggcacgttg tcgtaattgg ccagcagttg 8640
cttggtatcc ttaggcaggc agtaaccacc atagccaaac gatggattgt tatagtggtc 8700
accgacacgt gggtctaggc acaccccatc tatgatctga cgtgtgttca ggccatgggt 8760
ggcggcataa gtatccagct cattgaaata ggcgacgcgc atggcgagga aggtgttggc 8820
aaacagctta atggcctccg cttcagcact attggtcaat agcaccggaa tattctcttt 8880
cacagcacct gcattgagaa ggtcggcaaa aacttgtgcg cgatccgaaa tttcaccaat 8940
gacgatacgc gagggataca ggttgtcgta aagtgcctta ccttcacgca agaattcagg 9000
agagaaaatc aggttatcca cacccaactt ttcggaaatc attttggtat aaccaacagg 9060
gatggtggat ttgatcacca tggtcgcgtt gggcgcaatc gcctggacat ccttgatcac 9120
tgcctctaca gaggaggtat tgaagtagct ggtaaccgga tcatagtccg taggggttgc 9180
aatcactaca aaatctgcat tttcatatgc atcatgcttg tttgtagtcg cacgtaggtt 9240
caatggaata ttcttaagat aatgctcaat ctctttatca acgattggag aaattttatt 9300
gttgataagg tcaactttat cagggacgat atcaagagca acaacttcat ttttctgtgc 9360
taaaagcaca gcaatcgaca agcccacata cccagtacct gcaacagcta ttttcatagc 9420
aactatccta taaaattaaa tatgagaact tactatatgt cgtaagagaa aataattaat 9480
cgagagcctt attcacagtt gaaataatct catttctaaa tcgatcagga gaaaagcgca 9540
gtgcgttctc tctgcatgca aatggactaa tcttttgaga gagtagatta aatctagtaa 9600
tagcatccac gatggcatca gctgtctgct catggaagaa caaaccagtg gcaggatcac 9660
ctcgctcttc tggaataact gtctccaagg cgccaccttt ggcgaaagca atcacgggag 9720
taccacatgc ttgtgcctca acaggagaaa taccaaaatc ttcctccgcc gcgaagacaa 9780
accctttcgc acgctgcatg tagtctctta acacagcatg agactgataa ccgaggattt 9840
caacatttgg ccctgctttt gcacgcacct tggacatgtc tggaccatcc ccaatgacaa 9900
ctaatttctg atctgggatt ttggaaaagg cttccacaat caagtcaact cgtttgtaag 9960
gtaccaatct cgaggcagtc aagaaaaagt catctttctt ttcctggaat gcaaaactgt 10020
tggtatctac aggaggataa ataaccctag cctcacgtcc atataccttc tttattcttt 10080
tagcaataaa agaagagttt gcgataaaaa catctacccc gttcgccgtt cttagatccc 10140
aaatacgcaa tttatgtagc aaccatttga caatccaaga tttaaaacct gaaaccaaat 10200
tagactcacg caagtattga tgttgcaaat cccacgcata tctcatggga gaatggacat 10260
aacttacatg cacttgatct ggcccagtaa gcacaccctt ggccacggcg tgagaactag 10320
aaataatcaa atcatattga gacagatcga gctgctcaat agctaaaggc attagtggca 10380
aataattgcg ataatgcgtt ttagctttag gcaagttttg gataaaagtt gtcgtaacct 10440
tcttattctg aataaaacct ctcaggttat caggtaagaa ttcaatgaca gcaaaaatgt 10500
ctgcatcagg atagcaaaga accaactgct ccagaacacg ctctgctcca gcatattcat 10560
taagccaatc cacaacgata gctacttttt ttgggtgcaa tctcgaatgc ctcgtatatt 10620
tattagtcat aatctagtta ataatcaaca tgcctggcct agactttata aagaaaaatt 10680
cagcttggca gataatacta ttactttatt gtgaaaatct ccttgcacat ccgtgcaata 10740
tctattgcgg aatttttcca agaaaaatct tttgctcgct tcaagccttg gttgactaac 10800
gactttctca aatcggcatc atgagcaaca ttatctataa gctttgaaag ctcctgcgga 10860
tcatgcggtg aaaaatataa tgcagcatca ctgcacacct ctggaattga tgcagcattt 10920
gatgcaagta cggggcagcc gcaattcatc gcctccagtg gaggaagacc gaagccctca 10980
taaagtgatg gaaaaacaaa acaaagcgca tgttcataaa gcgcgcgcaa ctcattatcc 11040
gagacataac ccagcaacgt caccttagaa gaatctaact gggaattttc accaaaaatt 11100
ttctgattag ccccacctgc aatcaaatac ggaatatttg cattcttaga aagttttaaa 11160
gattcaatgg ttaaagaaaa atttttgtgc ggagcatgac tactaaccgc caacacataa 11220
gagcccgggt gaacttgaaa tttttcaaga atacctgcgt ctggctgttg cgacaaaata 11280
tgctcgccgc ctgcaccaac aacttgaact ttttcaggat gtacaccaaa aaagttaata 11340
atgtcttttt tcgaatattc tgaaaccgtt acaattttct ttgcgactct gccgagtact 11400
ggcatgagtg ttttgtacca cacccgaaat gctaaagaaa atgtactagg aattctcacc 11460
actgcagcat cgtgaatgac gacgatttga ctacgcacga agattgagcc tgtattacat 11520
aaatttaata ccattgactt actactcaga ctcaacatta gtagggacaa ttgctcccac 11580
gcatgcccac taaaaaaacc ataagccact ataggtatat gagttagatg caagtcagtt 11640
ttgatgcgag gaggaataac aatcttatat tcaacaccag ctacactggg atgattttcc 11700
gcaatcagtg tatttaactc ttttaatact tctattgcgt atcgatcaac cccagttatg 11760
cgtcttccta aaaatcggcc attaatatat acaatcaaaa tcttttccct accattatct 11820
tggatgcaag gttgatagat agttttgggt aaactatttt tctgaacaat tcgtatttat 11880
tcacaacaaa cttatcaagt actataggta tcaatattgc gataacaatg ccgatcacag 11940
cactatatat ttttgaatca ccaattgtga aaattaaatg attttgaatc gcattgtgaa 12000
ataaaagaat caataacgta gatttaccaa tactgctcaa gatagttgat aggtaggtat 12060
atttatctag aaaaattgaa aacaaaatac tgaaaaatat tcctaagatc atgcagagca 12120
tagccaaagg ataatgcgca atttttctaa aattcaaatc gacgtcaaca ccaaaactaa 12180
acaaccccaa cataacgaaa atcgcacaaa caatagatac aataagatat attgatttga 12240
tttcagtaat tttgtactta tcaacaaata cctttgcgta catacctaga agaataaagc 12300
cagcaccaat tattgctata tcaatactcc aaatcattcc tgaatttttc agactacccc 12360
aagcaagatt atcaattaaa taataatgaa ttgagttaat gagaaaaaca ccaactccga 12420
taaacaataa tgcaaggaaa aaaatcggac ttctatttga ttcacgatca gtgttattaa 12480
aatgatttga aataactaat gcgagaccga ccaaaacaat agagaaaaat aaacatggta 12540
taaaccagag aggagcaact tctattgtat gtccagttcc gtacaaaata ccaagaacta 12600
tattgaaaac accatcatct ggatttttca ttaaaacaaa aggaagaact aaaaatgaaa 12660
atacaaaata taccgcaata acattaatcg cccgcgtgaa atagtacgtt aatccttgat 12720
ctggcttgag ggttatacca ctaataaaaa agaacagtgg catatgaaaa agataaataa 12780
attttaccaa agaaagactt tggcccatta atatctgatt atgcccaacc acaaccaaca 12840
gcattgcaaa tccacggcag acatcgatcc atgaaatcct caatctcgca cctgcatcca 12900
cttgctaatt ccactgctca ataaacttaa cagcagttga tgttatagca gaaaccgccg 12960
atgttgtttt ggaattaagc ccatcagaga gcagtccgct aagctgcaca ccactgatct 13020
gcaccccagt tatctgatgt gaaataacgt ttttcccacc aattctaacc aaggtggtgg 13080
actccacttt catttggtta attaacacat tcttagcttc aacagcccag aaaataggcc 13140
aacttgattt atctgcgaat ccgaaggtat tgacattaat cttggagaaa ttagcagtta 13200
atgctttatt gacgtaaaga ggtgttgttc caatatttaa aaactcccca ttcactaact 13260
cgatgttatc cgccatcatg gttatgccac ttgcttttgt attcttgacg acgatatctt 13320
tcattttgac attaccgcca tgcctgtcga aaacaattcc atgcacgcgt ggggcattga 13380
cagtcaaatt ctcaacaaca attttatcgg tagcaccttg gactaggaaa ccattgccag 13440
ttgcctttgc cacgcaccaa gtacctgcct cttcaacaat gccgtttttg attgtcacat 13500
tggaaggaat tctagtgtca tagtattgct cacttccaat ctttaatcct tctgcggaag 13560
tgtgcctaat ttcaaacttg tctatagtca caccagattg accgataatc gcaattcctc 13620
gtgcataaga accattgata acaatgttgt tcgcataacc acctactgca tcgggatgtt 13680
ttttgtagtt tacaaacgcc aacccatcat cccctgtatt ggtagactga taatccaagg 13740
cgatgcagtt attgcaattt gcaaagtgca acccatcagc ccaggaattc caaaccgtag 13800
ctttaattac tgcacaatca tcacataagg taaaaatgat acctgtacct ggtgtgtcat 13860
aataaaatcc atctctaacg atgactttgg tacatctaga gaactcgtaa ataccaccat 13920
gtccaattct tctagctggg gggtttttgt acgaaaaatc tccaccaatg agtgataaat 13980
cactgcaact cgaaaatact aaaccactta atttatcatt caagaatttc agctgaaaat 14040
ctggtgcaaa ttttacggtg ccactcttca gtgaaaatct taaaggatta cttatttcat 14100
aataaccgct tagcacttcc gtgcgtccag caagcgcgtc atctaaagct ctagtgaagt 14160
ctgcattgcc cccgaccacc ttaggcgctg ccgaggcgac cttgggaagc caggatgaaa 14220
atagcatcaa gaataatgat ttaaccaggt gtctacgatt ttctatcatt ttcagtcctt 14280
cccttaacta taaagaaagc aataatcaca ccaataatct cggtaaaagc tcgggacgtt 14340
cctaaatacg gatatctgaa aatttccaat aacgtaataa aaaataacgg ataaaaaatt 14400
acacttaaaa aattgcctct caaatagcct ttataaaaga ttcctgcaag aaatgcggtt 14460
ataaagaagt agataatgcc aaatggcaag cccaaatcca ggatcactga aaatatccca 14520
gaagggttgt tgaactcctc atcaccatac tgagcgagaa actcacccat tctcatagtg 14580
tgcaaatcta cgtagtaacg aaacacgccg ccaaaaattg gaaatttatg catccaattc 14640
aacacatttt cgaattcata tgttggccag ttaacagtag ccagcattcc cgcaccatta 14700
ttgagcgagg tgtaataata tgaagcaatc cgccctagag caaaatccca aaaactcgat 14760
ttcccggcgt aagttgtaga gctccaagag cggaagtatt ccgccatacc aaagtaaagc 14820
accagcaagg gcaatcccgc gaagggacca gccttaatga agaattgcaa aattttaatc 14880
ttactgaaca cttgttgccg cgttatcaat aacgcaaatg gcaaaataat ttcaattaat 14940
gccagacgct ctgcccaggc aaatacccgc agcaatgtca ataaaacaat tgcatagaac 15000
aacaatacaa catcttgtct taaaggtaat ttggcgatat atctggcata tatgtaaatc 15060
gaaataaata ttggggtgaa gttaacaagt gatgtaatcc cttgcgttgc accaatttcc 15120
tgtcttgata aacctgtccc tgtaaatata ttaataatat tcataggatt gataatcagc 15180
tctttgaacc agtatatata tgctgcaact gctacatagc ctaatacccg caaagccata 15240
ttaacctgag agtctggcgg cactctgact tttgtcttga cgaagcttcc catccaggct 15300
gcacttgctg acagcacaac aattagcaca gccagagcta tatattcaga acttaaatat 15360
atataacccc gtatggttaa tgttggtgat ctcactgacc ccaaccacca gatcaacaag 15420
atcataggca aaagaaagcc taagcatagt ccatgagggg atagccacca tggaacattg 15480
gtttgactat cttgtggttc agtagttttg ttcattgctt tactttgaat aaatatagtt 15540
cagtattgtg atggttttac ttgcccaaga ctcatgctta gcattatctc gagcctgctg 15600
agccaatatt ttgatatccg cattgcaaac atcaccaagt ttatctgtga aaatctgggc 15660
attctcagcc aaaaatacaa agggtaatga tctgcgctca agctctggtg ttgaggtaga 15720
aacaacggga agtccgactg ctgcatattc aaacaatttc ataggactac ggccaaggtt 15780
ggatggatga tcagacatcg gcaataaacc aatttggcac tgactcaaga gattgggcaa 15840
cgctttatat tgcacatgac caagaaagtg tacgttggca agatcactaa atgccgcctt 15900
gtatttttcc tctactggcc cagccaataa aaatgaaatt ttctggtgtt ttgtggctgc 15960
acttttcagc acatcaaaac caaagcgatg atccagagct ccagcataaa ttgcccttgg 16020
ctcaggcggc aaatccagtt tggattttgt aaaattcagg taatgatcta gatctacacc 16080
attctgcagc aatagcacct catcaacacc taggcgattc aaatgctgtc ttacaggctc 16140
tgatgtcgca atgaagccgt gtacctggga tatcaaccct ttttcagcat ctacaatact 16200
gggatcattt ctgatttcat gataaatatc agtggggcgg tatacgatct ttgacttagg 16260
gaaatatttg agtagatagc ctaatcgagg ctcatcaatc aacactacgt caggattaga 16320
aaattgatgt ttacggagtt gtctgagtgc tgaaaacttc aggaagtaac caaagatatc 16380
gctaccagat cccaagcggg tggcaatacc ccaaggtatt aatgagaaag gaataatgtc 16440
ggtcacgtgg ttgatgacat cacccgcttt catccagcgc ttaaaccgga cacgctcaaa 16500
cggtgttttc tgcaacagtg tcagatgtgc tggtgtcact ggcggactga ggtggacaac 16560
ctcatgccct tgcaaggcga attgtttaga tagttgatgt gagccaacta caaattcgcc 16620
ccctgcggca gtgtgactta gaaataatat cttcaaaccc aatccccatt atttgacgag 16680
atggctcaag cgcctgttgt tgcagagacc aaaaaagtca tcccagatta ggtttaacac 16740
ccaaggatat gccaacgcac ttgcgccgca gagctggtgc gctgttatta agatatgttg 16800
ttaattcccc tgctggctgt ttgctagcat acccagcttt tatgctcaaa tcctttactc 16860
gatctccatt atcctaatgg aaacacaagg ctataaaatt atgatggaat caagtattta 16920
cgcttgtccc tgggcactgc ttgcaccaga tcgtgcagga actgttgttg tagctgcaaa 16980
gattgctcgg catcatcttc acccaatatc tgtgaggttc tgaccagtat cccatctacc 17040
agttgatgtt tgaggccttg ctccacaata taaagtcggg tctcccaagc actcttactg 17100
atcatatcgc ctatcctgat ccagtaaagc accagctctt cgcgctgtct tgaagccgca 17160
accaacgcct tggatgggat gggtgttgcg cctgccccca cattcactgc ggtatcctgc 17220
tgatttctga tggagaaacc ctgcgccgta tagcacagtt caggcctatg caccttgact 17280
tcctgccgct gcaatttgcc ataggcaaga gccagcataa tgacctgacc cttttcattg 17340
gcataactcc tcatgagaac ttcatcataa gggttatcga tgctgggttc gccatctctc 17400
ctgactgtca ggtccatctg cacctgattg gttttgactt cctgccactg accaaagctg 17460
ctaggcacga aactttcaag atgtggatca tcccgcacgg agctaagatc aggggtcaaa 17520
gccaacgcca ggccagaact caccaccatg catactgcca ggatattgat taatctgacg 17580
ctcatatcaa ctctgcaatc tagccttacg ctgtgtatgt ttgccaacaa agtattggat 17640
caggctatcc actgaaataa tcagggttaa tgccacgaca aataacaaaa tacccgcgaa 17700
tccatgtaca aagccctggc ccacttcatc cccgaaatag taggtgatca aggtcaacac 17760
aatcacgcgt atgacattcg ctgagaagga aatagggata atcagcaagg ccagcaacaa 17820
gttacgggcc agggaatcat gcctgacgat attgaggtag agcaggccca gggcctccag 17880
tgaaatcaag gtatgcatgc ctgcacaagc atccgccacc agcaactgat actgaccaat 17940
ctgaatgatc acacccgaac gcgcgatggg gtaatcaaac caatacagca catgctcggc 18000
cacgtaagag acagcgacct tcatcggcaa ggtcacaaca tccagcatgg agcctggcaa 18060
tggaatcatg aagaacaaga agaacaaggg gaaccagaag cgcttgaggg ttttggcctt 18120
atagaaaatc aacagcaagc cagccaatac cggaatctgc gagcccacat caaacaccag 18180
caaatcttgt gaacgcccga tgatgtatac caacaggcca aacaaaaaca gcaacaggcc 18240
cacaccacgc ccgctttgtc tcaagtttgc cgtgtctagc agtatttcct tgtccaccca 18300
gactaggtac agcaccacca tcaggatcaa ggggccatgc gcctgatcct gcatctgcca 18360
gaccgtgttc gtcaggttca ggtaggtggg cacaaataag aacagcaagc ctaccagcag 18420
tggtatcaca tgctggtacc ttcttagctg ggtactggcg accgcaatgc tctggttcaa 18480
gctcatttta gttttcagtc aataccgtgc caacaacagg caccctgatc ttggaaagct 18540
gatcaaccac tttgctcaag tcattggctt tggagacatg acgcttggca agaagcacca 18600
ccccttccgt agcacttgcc acagacaacg gttcagagtg gcggacaaag gaaggtgcat 18660
cgaccaggat aacatcgtag tcattagcaa ttgccgtgat gaactgcttg aggaaaccac 18720
gtcccagaag ctctcgcgga ttaggtggaa tggtgccaga agacaagatg gagagatgct 18780
cgaactcgac tagcctagtg atggaagagg agtaatccgt aacccggcct gccagaatat 18840
ccgacaaacc cgcagtgctc ttgatattaa aaatgcgatt ctgccgtggg ctatcaagat 18900
gggcatcaat gatgagtgtt ttctctccca gttgagagaa aaccacgcca agattggcaa 18960
ccaagtcact ggtgtcgtcc ttgtcgtaaa cactggaaaa tgacaggctc tttttccctt 19020
gtgcaaacca gtagagcatg agctggctac gaatggcgcg atacttctcc acattgatac 19080
tgaatggatc ataagccgcg accaagttct cggagaaatc gccgcgacca tccatcaggt 19140
agggataggc aaactgcttg gataatacat agttgatatc ggcagaggaa actaggccca 19200
aactctcggc agcctcacca aagcgaacgc ctctttcctt ctgcacacgc aggatacgct 19260
ccgcatcctg cggtgtaatc ttacccatct tgagcaacat tccaccgata ttgaaatcag 19320
cattcaatgc cggaatggaa ctagtattgg aaacatcatt agtcatgtct atatccacac 19380
aaattagggt tttttagcca gcaggcgctg aattctggaa tgggttttat ttttgtcgat 19440
cacacccagc agcggtgcgc caacaatctc taccagcact ctttctgagc gaattcgctc 19500
attagtgagc tcagccaaca aactaaacaa caagccaaaa attgtaccca gcaccaacgc 19560
aactgccacg ttcaatattt ttttcgggct tgatggctta agtggtggtg tcgctggatt 19620
aaggatggat acatcagctt gattagactg tccctcaaga tttatttgag tatatcgctg 19680
agtcgcgagt tcgtaagcgc gttgcgcacc ctcgacttca cgcgtcaata ccgtcagtgc 19740
atccctatcc ttgttcaaca gcatgacctt ggttttttgc tcagccaagg cattgcggat 19800
ttcactctcg cgttgcttaa ggattctata attgctcgat atattgacgg tagccgcctg 19860
gatttgctta cttaattcag acttcagatt gtcaagctca gctttggccc cctgatagag 19920
tgggtgattt ctctcatatt tttgtgagat atccgcgaag cgtgattcag acctagcaat 19980
ctctgttttc aggtgcagaa ccattggatt actcgcgaca tccggagatc cataagcatt 20040
gctaccttgt gcaccagtct gacgagactg tgcctcaaga gtttgccctt gtgacatcac 20100
taactgcgag gaaagttcat tcagcttggc acgttcaatg tctagacgct catcaacgct 20160
gacgatgctt ttatcttgtt ggtaatcgga aagcttttgc tgcgcccggg taatatcggc 20220
acgcaaatcc ttcaattgcc cggtataaaa ttcagccgcc tttttcgaag gctcaacctt 20280
gagttcgata gtggccttga tatattcctc ggcaaaggag ttagcaacaa cagcagcaaa 20340
tttggggttg gctccatcaa actccagctg caacacacta ctgttgcgcg caggttgaac 20400
ttcgatacgt gagatcagca aatccgccaa ccaatcaacg atatcacctt caccacctgt 20460
ggagtcattg aaactctcca caacctcact actttcattg agctttaatg tggtcacaac 20520
cctcttagca attttcttgc tagttatgat atccacctgg gtacccatat aacctggaag 20580
cagctgggca gggacagcca taccagtcac aggatctaca cctttatagt tgactaggat 20640
actggtggtt gccttatagc tgtttggcaa gaaaatattg agcgcaattg ctacgaccag 20700
ggccacaaca atggtgctta acaatatctt atatcgcgct ttgaatatca gtaaaagttg 20760
agaaaagctc attagattaa ccttgcctat caagtattta ttaaaatctg caatctatta 20820
aaagaaactt tcctgcacat agatcacatc gttgggcttg atgaggtcat catgtttggc 20880
agtgattact tcaatatggc cgctagcatc acgacgcttg atcttgacgc ctttttctgt 20940
gccgcgaggg cttaagccac cacctacaga aagcgcttgc aatactgtca tttcatgttc 21000
gagacggtaa tggctggcac gttgaacctg accatagata tagaatttat cgaaacgttc 21060
aacataaatg atgtcaccac cagctacgcg gatgttcttg ctgagatcgc cagtacgcat 21120
catgtcagca aggtcaatct gatccctgac cgctttacca tcgacgttat gcaccagcgt 21180
gatcagatcg ccaccttcag gtgatacacc accagccaag gcaagcacat ccgccagcgt 21240
tttagcgcta tctatagggt atctgcccgg gcgattgact tgacccagaa tagagacttg 21300
aaggctctgc aattgcgcaa cgatgatgtt gacgtgagca ctcttaagga aaccaccctt 21360
ttccagcatg gtggcaattc tttgctcggc ggcggcaacc gtaccaccac ccacacgcac 21420
ttcacctatc aggggataag taatggaacc tgattcactc actctgacct caagtgacag 21480
atcaggctgc tcgaacaccg atattttcag cacatcgcca gcgccgagaa gaatgtcacc 21540
ttctgcagca tgcgttacaa aaggcgtcag actcagcatc agcaagaaaa accatgtcat 21600
taattttttc attttactat cgtcctgata ttaaggatgg ggagtactta tttcaagcca 21660
ctaacaccac tggcgatatc atcctcagta gagcttggct tctttttggc tgccttggtt 21720
tcagtcgctg tttccatctt tttatcgatg tactcaatct tggcatcggc tttcaagcgc 21780
ttgacttcat tttcagcaac ttccttgcgc gccttattca gcaaattgtt ttcaatttgc 21840
ggtgttgctt ctgcaagtga aactgggctg tccttgatct cgttcatcat gatcaacatg 21900
gtgcgagggc ccatgccgat cacgaacaac ttacccttat cctcggcctt gaggcgctcg 21960
gaaatctgtg gcggcaattc agcaacactg cgtgaaacct gaccttgatc gtactgaata 22020
ttatgggcat ccatccatgc ggctacttcc tgcaaggtct tgagtttgcc aagtgctgtt 22080
ttcaattcat cattggcgaa tttagtatca atcaacaatt gatccatttc caccattctg 22140
cgcttgctga agaattgagg attctcgtta taaaaattct caatttctgt tttgcttggc 22200
ttggcgacac tgcctaactt ggattgcaga tatgcctgag caatgatttg tgatttcgca 22260
cgttcaatcg tggtcatcac atttggatcc ctatccacct tggccttgag cgcagcttct 22320
tcaagtaact ggcgatctat caatgcagtc agaatctgct gcgttgcctg ctcgcgctga 22380
ttctcctgaa tgttggcacg acccagctcc tgattcagct gatgtacggt gatttccttg 22440
ccattgacct taaccagaga ctggctggct ttggattcat gcttgtcgcc acagcccgac 22500
aatgcgaaag cgagcacaat cacagcaccg acacacaggg ttctggattg cttgaagtta 22560
gttacaaatc cgttattcac tttccaatct cctcaaatct atttaaacaa cctagtaggc 22620
gttatctttt ttgaacacaa ccagcaccgt cctgacgata atccagaagt caaaagccag 22680
ggaccaatgg cgcaaataat ccaagtcata ctcgatacgg gactccatct tgtccaaggt 22740
atcagtttca ccacgtaaac cattcacctg cgcccagcct gttattccag gcttgacctt 22800
gtgccgcagc atatagccac gaatcagctt gcgatattgc tcattatgag aaacggcatg 22860
cggtctaggc cccacgatac tcatctgacc ttgcaacaca ttgatgaact gcggcagctc 22920
atccagtgag ttcttgcgca agaaaccacc aatcggtgtc aatcgctgat ctcgcttctg 22980
cgcctgtact accttgtcac catcttccat tactttcatg gagcggaatt tatagacaat 23040
gatttcctca ccattcagca taacgtcgct gcttgaaaat caccgggcct ggggaggtca 23100
acttcacggc cagagccagt gtcagcatga tgggagacag cattaataga ataagcgacg 23160
ccaaaataat gtcactagtc cgtttgatta aactgttgaa accggtgaat ggcgtctcaa 23220
gaatagcgac cacaggcaca ccagccacat catcaaagcg cgcttgtacc agatcaaaaa 23280
tatagatatc cggcacaaag taaatagatg ctgtggtgtc ttgcaattct tcaaataact 23340
gcctgatgcg tggctgcgcc gacatgggca ggctgatgaa aataatctgg gtattattgg 23400
cgcggacata tggcgcaatt tccgacatgg aaccaagcaa aggcagatta cgcatgccct 23460
tggggtgcct ggcgacctct ctgtcgtcaa agatcccctt gacctccata aacaggtacg 23520
ggtcgtccgt gatgcgattg atcaagcgca cgccaatatc attggcaccg ataatcacta 23580
cggacctgac ttcaccattc ttgtgcaaat ccgaggcaat tttgcgtatc gccagatgcg 23640
tgacaataaa tatcatcggc acactggcaa accaggcata tatcatctca tccagatact 23700
gactggatag atcagcggca tagccgatga acatcagcac agcgatgaca ataccccagc 23760
caaagagaat atcgcggata taaccaagta tcttgccact acgccaggta cggtaaagat 23820
ccagacgctc gtagacatta gaggaaacaa agtaggctag caacgccaga atcaggtagt 23880
agccattaaa aggctcacca aacaacaggg tgaacacata cagcgtacca agaatgatca 23940
gcgggtcgag cagctgcttg aaaaacgcta ctaaagggat gtcatttacg gtcatttatc 24000
ttacaccatc agaattcata acgaccagta agcgaaatgc ttgtcgagtt gtagtttaaa 24060
attggtgagg ttgagtcacg caaacttcta tttagaccag tagtgaaact taacgattca 24120
agagggctgt acgttacccc aaaagaaaaa accttattct tgtcggtacg accttgatct 24180
tgcccggtga tatcgccttc aaattttagt tgttgatacc tggctgaagt tgacagcagg 24240
atcttactcg ttgcgctata ggagatgctt gcacttgcgc cactatcaat cacatagctg 24300
gcagttacga ttgatatagc atttgcatcg cgccatgcgg ctgtcttgaa agaggttttg 24360
tcggtaatgg accacaccat gttcccgtgg gcattaaatc cggaaaaatc gcgctgtgag 24420
aagctgtcat gtttacgatc aacatacccc cccaaaaatt caaatcgtgt tttggcagaa 24480
taaagccaaa gtatgtccgc cttgagtgat tgctgcctgt agtcattatt gacaaacacg 24540
gtaccaatcc ccgggaaaaa agcaggccta tcaaagggcc gcgtgccacg cccattagtg 24600
aagaccaagc caaccttact gcctgactca gctaaatagt ccaaacctac gtgctgggaa 24660
ttttcctgaa aagaagccgc attcaatgtt tgagagtcat actcaacatc ctggcgctgc 24720
acaccaaagc gcgcgcgcca actggaatgg aaacgccagt ttgcttcaaa agttttacgc 24780
tcctgaatac gcatattcaa ttccacacca cgaaaatccg caaaaggcag catagcctcg 24840
tttttatagt actcaacctt gccccggaat tgcgagccca ctgcccagtt ccatcgagcg 24900
acaatatctt tacctgtatt gtctaactct gaatttttgt tgtatttggt ttcattcaca 24960
ccgatattgg cgtagaaatt ctgctgacta atatccttat ccagaataat gccaacccgg 25020
cccactacac tcgtatcgga ctccttgtca gagcggcgcc tcaggttgtc atcataaaca 25080
tatgttgcac tgacataggg ccgtatgaca tcaccttcac gagccagcac agggtcggaa 25140
taacccactg cattccaacc tatgactgcc gtgataacca gctttttata atgagtagag 25200
tctgttagtc gcaaagaaat acttccccaa tggctaccag taatgccagt taccggtata 25260
gataatccaa actcccaata caccgttggt caccgcatgc gcgatgatcg gcatccatat 25320
tgttctgctc cggatgtaaa gcaatccgta tgccagcccc gcaaccagac cagcaaacca 25380
taggttatgc tctatggcaa aaagtagtga agaaaccagt aatgccacag caccaaccgt 25440
ggccggctcc accttgagga agtcctgatt ttgtatccag cgcatcagga aagaacgcca 25500
gaacaactct tccatcagag gcactactag ggcagcaccg acaattcttg tcaccattag 25560
gagacacgct tcgacaccct gccccggatt gaagccttgc gatggcccgc ccagtaacat 25620
ccacggggca tccaggttaa tccaagcgac aaatactagc acaccaatgc tgattgcgct 25680
caaccacgac ttcaaactaa gcaacgacaa gccaccaagc tcgatatagt gtttgcgcaa 25740
tgtccaaagc aagtaggcaa ccaagccaac cttgactcca tataaccatc gcagatcaaa 25800
accctcaggc acaactgcgc cgatcaggtc tacccctgcc atgaatagca tatagaccgc 25860
gaagggaata acacggctac ttatcggccc cagtgatgcc ctgttcatgc atgtgcctta 25920
gtttgaaata cgctcatgat acaaaatcaa atcgccaaat gacaggcatt ctcatttcaa 25980
tagtccctat ggactaaatc agactcactc actgcatgaa tggccttgcg gatgctactg 26040
tgcaactgct atagatttat gacaagtctt gtcacacctt cgctcgccat tcccagtatg 26100
tgctacaact tcaggaatag gcaccaacac aatacccaaa atgaataagt cggcatgaag 26160
ccgacttatt catttactct tagcatgact aaatgcacgc ctgataagcg cgtgcattta 26220
cgtgctcagc ttaattaagc ttggcgacga cgtgcagcaa agcccagcag tcccagacca 26280
accagcatca at 26292
<210> 179
<211> 26076
<212> DNA
<213> 糖原甲基菌
<400> 179
atgttaaaaa aagtagctct aattacaggt atcactggac aagacggagc atatctagct 60
gaatttttac ttggcaaagg ctatgtagta catggcatta agcgccgagc atcacttttc 120
aatacagatc gcattgatca tctgtatcag gaccctcacg tcgataacca gaatttcatc 180
cttcattatg gggatttgac agattccacc aaccttatac gtatcattca gcaggttcag 240
cccgacgaaa tctataacct cgcggcaatg agccacgtgg cagtcagttt tgaaagtcct 300
gaatatacgg ctaacgcgga tggtcttggg actttgcgta ttctggaagc tatccgcatc 360
ttggggctgg aaaagaaaac ccgcttttac caagcctcga cctcagagct ttatggtttg 420
gtgcaggaaa caccgcagaa agaaagcacc ccattttatc cacgcagccc gtatgcggtt 480
gcgaagcttt atgcatattg gattactgtc aattaccgcg aagcttatgg catctacgcc 540
tgtaatggta ttttattcaa tcacgagagc cccttgcgtg gggagacctt tgttacccgt 600
aaaattaccc gtgccttggc gcgcatcaag ctgggcttgc aagattgcct ttatttggga 660
aatctggacg cgttgcgtga ttggggtcac gccaaggatt atgttgaaat gcaatggctg 720
atgttgcaac aggaacaggc agaggatttc gtcattgcga caggtgtgca atacagtgtg 780
cgcgatttcg tcaatgcagc cgcccacgag ctggatattg ccatcacctg gaaaggtcag 840
ggccaagaag agatgggata cgacggtcaa ggcaggtgca ttgtacaggt tgacccgcgc 900
tattttaggc ctaccgaagt tgaaacattg cttggtgacc cgagcaaggc aaagcaaaaa 960
cttggctggt cgcccagcat cagtttccag gagttggttt ctgaaatggt gcgtgaagat 1020
ctcaagagcg cagagcgtga cgaactggtt aagcagcatg gttttgctgc ctatgactat 1080
aacgagtaac ctgagcctat ggacaaacac gcacgtatct atgtggcagg gcatcgaggc 1140
ctagtgggtt ccgctatcgt tagggggcta gagggcaagg gctatagcaa tcttatcaag 1200
cgtacccatg cagagcttga cctcacagat gctaatgcca cggaagcatt ctttgctcag 1260
tatcagccga atatgttttc ctggcggcag ccaaagtggg tggcatagtg gccaataaca 1320
cttacccggc agattttatc cgtgacaatc tcgcaattca gaacagtgtg atccatagtg 1380
cctggaagca tggagtaaag cgcctattgt ttttagggtc cagctgcata taccccaagc 1440
atgctcctca gcccatgcat gagcaccact ttctaaccgg atcgcttgaa gctaccaatc 1500
gtgcatacgc gctggcaaag attgctggag tcgaaatgtg ctggagttat aaccggcagt 1560
atggcactcg atttcttgca gcaatgccga caaatcttta tgggcctggc gataactatc 1620
acttgcagaa tagtcacgtt atccctgcat tgatacgcaa attccacgag gctaaacaag 1680
ctgggcatgc agctgtatcg gtctggggta ctggaacacc caggcgcgaa tttctttaca 1740
gtgaggatat ggcagatgcc tgtatattct tgctgaatct gcctgaggag aaattcaatt 1800
ctctgctggg aagtgatgag agtgctactg gtgtgtttga tccaccacta gtcaatatcg 1860
gtattggagt cgatatttca atacaggaat tggccgaatt ggtaaaaaag gtggttggtt 1920
accaaggagc aattgagttc gatagttcaa aacctgatgg cacgatgcgt aagcttatgg 1980
atgtaagcaa gctcaacagt ttggggtgga cttattccat tgagcttgat gatggattgg 2040
aaaagacata ttcggaattt ttaacaaaat aaatctgagt ttattaattt atttctgata 2100
tcgaattgat attatcctca aaaatagcgt ttagataatt tatataacct cgataatttt 2160
taaaatttaa tgttcaattt tgaaaaaaaa agtgtttgct ttgattcctg ccagagcagg 2220
ttctaaagga gtgccaaaaa aaaacctgaa aaatatcgca ggttctccat taatagctta 2280
cacaattaac gctgctaaaa aagctaaaaa tgtcgatgct gtttatgtat cttctgattg 2340
taaagaaata ttggagtatt caaaagcaca aggctgcagt tcaatattaa ggccgcaaga 2400
atacgcaaca gatgatgcgt cagctgttga tgttgtcaag cattttatta gtattgaaaa 2460
tatagaggat ggagatttaa tcgtttactt acagccaacc tccccattaa gagatgaaca 2520
tcatattgat gatgctttga cggctttgaa taataatggc cttacttctt tggtcagtgt 2580
ggaagtcttg gataagtcgc catataagtc atttcgtcta gatgataatg ataaattgat 2640
ttcattattt gatgaaaaat tatctaatta tcgtcgtcaa gatttgccat tatgttacgc 2700
gccaaatggt gctatttata tcttttcgaa atttgaattt gaggctagag gcggtttccc 2760
ctccaatggt agtgttgctt atattatgtc tgctgaagaa agtgttgata ttgacaccga 2820
agaagatttt ttagaaacag aagcattatt aaggaaaaaa tatggcatct tttgaaattt 2880
ctgggcggaa aattggggac ggacatgagc ctatagttat tgcagaaatt ggcatcaatc 2940
acgagggttc attagatctt gcgattgata tggcaaaagc tgcaattgat gctggggcag 3000
agataataaa acatcagaca catgtggttg aagatgaaat gtctgatgaa gccaagagtg 3060
ttattcctgg aaatgcggat gtttcaatct atgagattat gcaacgttgc tcattgtcag 3120
aggatgatga atataagctc atgcaatatg tgcagcagca aggcagtatt tttattagta 3180
cgccattctc gagaatggca gcaaatcgac tgagaaaatt tgatataccg gcttataaaa 3240
ttggatctgg cgagtgcaat aattatcctc tcgtgcggca tattgcttca tttgggaaac 3300
ctattattgt tagtaccggt atgaatagca ttgaaagcat tgcaccaacc gtcaatatat 3360
taaggcaagc aaaagttcct tttgctcttc tgcactgcac gaatatttac cctacccctc 3420
ctgagcttgt aagacttgat gctatccaag tcattaaaaa tgcatatcct gatgcggttg 3480
tgggactttc agatcacacc cttgggaatt acgcttgcct aggggctgtt gcactaggag 3540
cctcaattct tgagcggcat tttactgact ccatgtcacg gccgggacca gacattgttt 3600
gttcaatgga ccctgcagca ttgcaagatt taatcactgg ttcaaaagtt attttttcag 3660
caaaaggtgc acataaaggt ccacttttag aagaagaaaa aactatagct tttgcttttg 3720
catctgtcgt tgcaattaag gatatcaatg ttggtgatgt cttaagtgaa gataatattt 3780
ggttacgtag gccaggtggc ggtgatttta atgcttctga ctatgatcag ctacttggtc 3840
gtaaagcatc gcaaactata ctgagtggca aaagagttaa tcggcaggat attgaggcat 3900
gagtaggcga gttgtttttc ttactggaac aagagcagat tttggaaaac tgaaatccct 3960
catgcgagca ttacaaaatg acatgggatt tgacgtccat gtgttcatta ctggcatgca 4020
tatgttgtcg aaatatggtt atacatgtga agaagtagaa aaagccggat ttaaaaacct 4080
atttcgcttt atcaatcaaa atcaaagcga tagcatggat catattctgg ccaaaacaat 4140
tactggttta tcagattatg taaaagaaat ttcaccagaa ctgattgtga ttcatgggga 4200
tagagttgaa gcgttggccg gagccgctgt tggcgcatta aataacattc gagtggcaca 4260
tattgagggc ggagaggtct ctggcactgt tgacgagttg attagacatg cggtgaccaa 4320
gctgtcccat gggcattttg tttccaacga acaggcaaaa aatcgactta ttcagcttgg 4380
agaaagtgaa gaatccattt ttgttattgg ctccccagat attgatgtta tgaattcaac 4440
atcgctgcca agcattgatg atgtgaggga acgttatggc ttctcgttcg aacattacgg 4500
cattttgatg tatcaccccg ttacctctga gttagatgat ttgccaagac aagccaaagc 4560
catcgtagat tatatttcag aaagctctct accattcatt gttgtatatc ccaataatga 4620
tcatggttca gacattattt tgaatgagta tttgcgattg aaaaacttga gccacgttag 4680
agtttatcca tccattagat ttgaatattt tttaacgctg ctaaaaaaat gcagcgttca 4740
tcatgggtaa ctctagcgct ggagtaagag aggctcctca tttcggcgtg ccagccatca 4800
atgttggtag caggcaacac aatagagcaa cagcagagtc gattcttaat actactgcac 4860
atgtggattc ccttagacat gctgttcaac aagttgcaga cattcctcgc gtggcagttt 4920
ctgactttgg taatggtaat agtgcaggtg agtttcatca gattctgttg aataatgctt 4980
tttgggataa gggcatacaa aagcacttta tcgataggag tgcagtgtga ggttgatcgc 5040
aaggctagat gtcaaaaatg aacatgtgat taaaggcata cacctagagg gcttgcggaa 5100
agttggcgat ccaatcgaga tggcgaaaaa ctattatgca caaggcattg atgagattgt 5160
gtttatagat gcggtagcga gcttgtataa ccgtaataac ctgctgtctg taatcgccaa 5220
ggcttcggaa gaagtttttg ttcctatcac tgtagggggg gggctgcgtt ccttagcaga 5280
tgtcgagatg gctctgagtg ccggagcaga caaagtggca gtgaatacag ctgcaatact 5340
taacccgaaa ttcatcacag agattgccaa gcgctatggc agtcaatgtg tggttgcctc 5400
tattcaagcc aaacggatag gcaatgactg ggaagcttat atggaagccg ggagggagcc 5460
tacgggcaaa aatgttgttg cttggagcaa ggagctggaa gatcttggtg caggcgagat 5520
tttgctaacg tctatagacc aagatggtac aaaaaaagga tttgaccttc cattgcttgg 5580
tgcagttaac acgatagtga acattccagt catggttagt ggtggctgcg gtaatcctga 5640
tcatgtgcaa gagttaaaag aaatccagcc aagtggagtt tgtctggcgt cagtattgca 5700
ttacaaaatc aatacgatag atgaattcaa acagcgtctg acattcatca atggtactaa 5760
ataaatgaag aaaatatgta ttcttgatta tgggctaggc aatgtgcgta gtgtgagtaa 5820
tgcgatcaag tacgtaggtg ctcatcctgt aatctcaaat acgccagagg cacttaaaga 5880
ttctcacgcg ttaatagtgc caggggttgg tgcgtttgct caaggcatgt ctgcattggg 5940
taaagatgga ttacaagcta gcttgctcga atatataaaa agtggaaaac atgtcttggg 6000
gatttgtttg ggcatgcaat tgcttttcga caggggtgag gagtttggcg ttaccactgg 6060
tcttggactt gtgcctggcg tagtctccag aattgtaccc gtagagcaat cacgagtgag 6120
gttaccgcat atatcctggg cgaaagttga tctcaattcc gttcatgaaa ataatggcgg 6180
catgtttgat ggactgccag acgagcagcg taagttctat tttctgcaca gttatgccgc 6240
tcaaaatgta cctgatcgat acatcacagg cagcgcgacg tattctggat gtacttttgt 6300
tgcatcagtg cagaaagaca atatctgggg tatgcaattt cacccagaaa aaagtgggcc 6360
cagcgggtta caggttctta ataactttgt acaaaacagt taattgaaaa gaagtgtgga 6420
ggaagttgtg gttaatgcat attttggttt gccggaagat gtagtgtttt gcaagaaatg 6480
cgtgatttcc aaccaaagac ccagttctac agttgaattc aagcatacca acaaggacaa 6540
aaaagcgacc ataggatttg gcgctgatgg tatttgtgat gcttgccgct atgcagaaac 6600
caaggatgct caaatagact ggcaggcccg cgaggacgct ttggttagat tgttggatca 6660
acatcgccgt agcgatggtg gatatgacat tgtcgtgccc ggcagtggtg gtaaagacag 6720
tgcatatacc tcacatatcc ttaaatataa atatggtatg aatcctttaa cagtgacgtg 6780
ggcgccgcat aagtacactg agattggttg gaagaatttt gaaaactgga tccataaagg 6840
tggattagac aatattcttt ttaccccaaa tggcaagttg caccgctatt taacaaaaat 6900
ggcatttctg aatttattgc acccattcca accattcatt gttggccaac gcattatcgg 6960
gccgttgatg gctaaaaagt ttggtatcaa attggtaatg tatggtgaaa atcaagctga 7020
atatggcaat aagacagaag aaaactataa accgacaatg gacaagaatt ttttctctat 7080
ttcagaccca gctgacatgg tgttaggtgg tgtgaaggtt ggagacatta ttaaagacgg 7140
tgaatacagc ttaaatgatt tcgcgccata tattccgcct gctgcagaag atctagagcg 7200
cgatggtatc gaggtacatt atttgggcta ttacctgaaa tgggatccac aagagtgcta 7260
ttactatgca gtcgagcata ctggtttcca ggcaaatacg gaacgcactg aaggaaccta 7320
ctccaagtac agtagtatcg atgatcgaat agatatgttc cactacttta ctaccttgat 7380
caaattcggc attggtaggg caacatatga tgctgcgcaa gaaattcgca acgataaaat 7440
tacgcgagaa gaaggggttg ctctagttca taaatatgat caagagtttc caaaaaagta 7500
ctttgcagaa ttccttgaat atatagagat caccgaagca cagttttggg aaaccgtaga 7560
taggtttaga tctccacatt tgtgggaaaa gcaagacagt aattggatac tgaagcatca 7620
ggtgacctaa gaatgaaagt gttgcagata ggaagtttct ccggaaatgt cggtgacatt 7680
gccaaccatt atggttttcg caattggttt caaggactgc ttggagagat tcaatgggat 7740
gaattcgaaa tacgcaatgt ttaccgaaaa aatgttgcct ttgacgataa ttttgtagct 7800
attgcaaatc agtacgatct tatagtcgtg ggaggtggta attttttcga gctatgggtt 7860
gattcttctc caaccggcac ctcaatctca attgagattg aggtttttaa aaaaataaaa 7920
gtccccatct ttttcaatgc attgggtgtt gatgatggta tgggatgtag tgatgaaagt 7980
cttgcaaagt ttactaattt cttagaaatc ttaacttcat caaagcaata tttggtcagt 8040
gttcgtaatg atggagcaat gggcacgctc agaaatcgga tttctaataa tcccatgttg 8100
gataaagtct taccattgcc tgacggtggg ttttttgtaa atctggataa gttagaaaaa 8160
gacattgcgg aaaatgatca tgaaaacact cagatcacca tcggcatcaa tctggctgga 8220
gatatgttgg aaacaaggtt tccaggtgga attaatggat atgattactc aggatttata 8280
tccgagttca ccgagacttt ggctgaaatg tggaataaaa ataaattaat aaagtttatt 8340
ttttttccac atatttatag tgatcttaaa gtatatgccg acatactatc acggttgcct 8400
gatgcatgta gacgtgaaaa tgtcaaagtg gccagttacg atactaatgt gaattttcaa 8460
gggacattat tttccgaata tagcaaatgt actttgatac ttggtatgcg atttcatgcc 8520
aatgttgtag ccatagctaa taaaattcca gtaataggat tgtactcata caagcaaatt 8580
aaagaattgt tttatgagtt gggaataaaa gaaaaaattg ttgatgtcag acaaataggt 8640
tttaaaaatg aattgttgag aaagtgcaat attgttattg aaaattcatc tatatctcgt 8700
gatgagagct gtaacatact tgatgttgtc acaaaaaaac gtgatttgat tgctccaagg 8760
gtagtggagt ggttacgtga gcataagctt aaatgattaa ttgttgtaat tgtatgctta 8820
gttattatga ttaaaagcct tgattatcta agggcgattg cagcactaac ggtttttctc 8880
agccacacct ttcaaattta ttggttacca accattggat tggtgtcctg gaaatatgag 8940
ttgaatcatt ttttgagtga aaccgcggtc ctcttatttt ttgtattaag tggctatgta 9000
atttcgaata gtttgcatag caatactcaa cgtaatggag ggcgtctttc agtacttgat 9060
tacgcatcta gcagattatt gcgcatatat cctcctctca ttgtaagcat aataatatct 9120
ttagttgcct atagtgtgat tgtgatcttt gaactaccgg gatcagtggg tactttaaag 9180
gcaccaggag atatctatca ggcaagagac tacttgagca ttggtacgcg agacattgtc 9240
aattctttat tgatgaataa tggcttgttg caaatgaatg ggccattatg gagtttatgc 9300
attgaggcta agctatattt ttatgcttgt ttagttgtaa taatttttat tcattataaa 9360
caaaaaaatt tgctcaattt tattgctaat actggttttc tcgtattatc tgtattcttg 9420
ttttttaata caaaaaccga tatttattat ggcttatggt ggttgagcgg tggtgtaatt 9480
ttcttatatc gtcgaaattt cataaagttc atgactttgg ttgttgtaat ggctattgtg 9540
gtgtttgcta tggcagtgat tggacagaag ttcgtttctt tgccagtgca agttatattt 9600
gtatattctt tatttttggc agcaataaaa tgcaaagtgc cagaaattaa ggcaatgaat 9660
attttggcca atacttcgta cactttatat attgtccatt tccctatgtt gttactatcg 9720
tacgccatct tctcatataa ctttgatgtg tacggtagcc tgactagaga gttgatgtca 9780
tcattatcgc taataatcat cttaactatg tcaatttata ttggaaaatg ggtagagcgt 9840
ccagctaatt tacgtttgac ctatcacagg ttgttgagaa aagtaaaagt atgaaagcca 9900
tgttttattc tttgcatgca gctatttggt tacatgcgct tcctgaaagc cggttggcat 9960
cacagctgag taatgccggc catgagttag tatatgtgac ctgtgataaa agctttactc 10020
attattgcac tggtatgagt gctttcaatc ttgcattgaa tgaggatttt aaaaagaaaa 10080
gtgcaatttg tgagttatgt attaataacg ccaataaaat aaccaagtct tttgattgca 10140
agcatcttaa attgcatgat tatattgatc agaaaactaa tgctctgatt gataacctat 10200
tgaaaagtgt cacggaagat aatttcctcg aatttcatta tgaagatata ccagtagggc 10260
gtttggctac atatgagcca cttcttaagt ataagaaaat gtctttggaa tttagagatg 10320
aacaatggca agatctacag attcacctta ggaatgccct ggtatcgtta atcggtttta 10380
tccaaatatt caaacaagag tgtccagaaa aaattttctt ttatagtcca cagtatggtg 10440
ttaatggtgt gtgtgcagaa tatgcagtaa aacaggggag acaggcatat tttatagaag 10500
gtagctctag caatgctgaa cgatatagtg ctttaagggt gtgggagtgg agtaaattta 10560
aattagtaaa ccctgcattg cagcattggc aagctgttaa aaatttagta acgcttgaag 10620
atattgatag agtctctgca catattcacg aattattcaa aggtaaatct tttgctgttt 10680
tttcagcgcc aaaaacagga aatttttcaa tccgtgaaaa attcaatatt ccacagaatg 10740
ctaaaattct actcgcctca ttaagtagtt ttgatgaagc gtatgcggct tttgttatca 10800
aaggttttcc tgagcgtaaa gttaaaagtc cggttttctc agatcagttt gaatggatta 10860
agtgtacaat taattttatg aagtctaggc ctgatgacta tcttgtaatt agagtacatc 10920
cgcgagacta tcctaataaa cgcgattcca atcagtctga gcaagcattg atttgggaaa 10980
aaatacttca ggatctccct gagaatgtta aattaaactc accagatcag aatatttctt 11040
tatacgattt tctcgatgat gtacatgcgc tggtaacagg gtggtctgcc actggtgtag 11100
aagcattgct acatggcata cctgtgatta cctatgataa atacttacct tcctatccgg 11160
cggatataca tctaacggga gagtctgaac atgagtatta tgacaacctt atcaaagtac 11220
tttctttggc aacatcaaca gataatacac atgtagttaa tgcctatcgc tggctcgcgg 11280
tcagtttttc actgggcact gtcagagtta atcagccact ggagattggt ctgagttggc 11340
cggataagcc ggcgtataga atattgaaaa gggtggctaa caagttttca gttaatttgc 11400
gaaaaagcta cgacgtatgg aatgtccagt ccaacgacac agaccgttta agatttttaa 11460
gtctggttct taataatcaa tctagccttt ttgagggtgt aatatctgat gtggtcgatg 11520
ctgtttccga ttatgaaatt gaagctacgg taaaacaaca ttcgatataa gttaattatc 11580
tgatatttaa tacaatttat atttagtaac acttaccatt aaaatgaaag ttgttgaata 11640
aattgccaca agcaaaatat atttttaagt tattaaaatt tgctttcaat aacaacccat 11700
tgttgtattt gagtgtttta atttctatac tttctatagg tattgaattg ttggcaatgg 11760
caagcctatt gcctttattt gaacttgttt caggagaaac agtagataag catggtttga 11820
tttcaaaagc tctgattata ttggggttta cagttgatgc tgccagcctt ttgcaagttt 11880
tcttcttatt gttcactttg agagtagtca cgcaactatt tagtcaaagc ctgacgcact 11940
accttggaag acgtgtgatg gctcagctcg gttctagggc ttttgaaaaa atcattactt 12000
cgatgtcaat tgataaaata tctgaaaaaa gtataggttt ttttatgggg cttgctggag 12060
atgaatcctt cagggcgagt actctggttg ttgcattgac tcagtttgtt gcaacatttt 12120
tactgggggt aatgtatttt atttctattg caatttattc actatatgcc gccgaaatga 12180
ttttcatttt aatgcttgtg tctgccgtat tcttcatttg gattttaaaa atatctcata 12240
agatgggcgt gaggcaaata gaaggttcaa ggaaagcaaa ttccattttc atggatgcga 12300
tgaacaatat caaagcagta agatcacttt cttccgagaa gtatgttgcc ggtttgtata 12360
ggcgaaagat ttttacgtat gcaaatattc ttttttacct tgatgcaata aatctggcta 12420
cgaagttagt accaataata tttctattac tcggatcttt ggctttgata ttgagtggct 12480
gggtttctgt tgaaaactta gggatggctt acattgtgtc attgatagct tatctcatgc 12540
gatttttccc agttgttggt cagagtatca ctctagctgt tcgcattgtt gcagatgcga 12600
aatcgggaaa agatgtgacg gaattagttt ccgatgaaag tgccgagagc gctaattcag 12660
acaactattt acacaagata gatacaatca agattgataa tttgtcgttt tcataccgtg 12720
atgttcaagg cgtaaggcca gcggttctca attctgttta ctacgagttt gaaaagaaca 12780
actcttatgc tttagtgggg aaatctggtt taggaaagtc tactttgctg gatgttttgc 12840
tgaagtttta tcctcctgct tcaggcagta tttcaataga tggtatttca acagaaaata 12900
tccctggagc acatatcagg cattctattg tacttattaa tcaagaacct gcgatttttg 12960
atgatacggt ctacaacaat atttgtatgg gcgagacttt tactctagag gacgtaaaat 13020
gggcttgcga attagcttgt atttctaaag atgtggaaag tcttgcgcaa ggttatgaaa 13080
cacgtttgca atatcaagga aaaaatcttt caggtgggca gcgtcagcgt atagctattg 13140
ccagagcatt agtgcgcaaa cctaatgtgc tgatacttga tgaaagtaca acagctttag 13200
ataaggctac acaagaaatt gtgatacgga atcttatgaa tgagtatgaa aataagatca 13260
ttatatttgt cagtcatgat ccttatatca tgtctcaagt cgatcataca gttgatttgg 13320
cattaatcaa taaagtataa atttatgtct atctcaagta ttgctttaaa aatatttaat 13380
tattcgcaag agattttttc attttaccgg gatagaggct tatataaatt ctcttatgcg 13440
caagaggggg aagatttaat tctgagtaga atttttgacc gaacctctac tgggtattat 13500
attgatatag gtgctcatca cccagtaagg ttctccaata cttatttatt ttataaacgt 13560
ggttggaggg gagtttgtat agatccctca cacgaggcta ttgctttgtt taaaacacgg 13620
cgcccagcag atattgcctt ggaaatgggg gtatctgatc atgagtctga gctgacttat 13680
catatgttcg atgagcctgc tctcaatacc ttcagtgagg aattggccaa tcagcgtata 13740
caaaacactg cttataaacg cgtcggtacc cgcaaggtgc cagtaagacc cttgactaaa 13800
attttggatg aagtgctgct gccggatact gaaattgatt tcatgagtat agatgttgaa 13860
ggctttgatt accaagtgct tgcctctaac gactggtcaa agtacaggcc tcgtatagtt 13920
ctggcagaag cacttgatga tgtcgctggc gaacgcatac gcagtttcat gattcaaaat 13980
cattacaaag tcatagcgcg tacattcaac actgagtttt atcaagatct tttgaaactg 14040
taagtaacca tgtccaatct agcacctgtt gccctgttta cttataaccg ccctgaccat 14100
actaaaagga cgattgaagc actgaagaat aataccttgt ctgctgaaac ggacttgctg 14160
attttttctg atgctgcaaa aaatattaca cagcaaagca tggtggatgc tgtcagagcg 14220
tttactcaca ctgttgaagg cttcaagtca gtaagaatca tagaacgtca aacgaatttt 14280
gggctagctg cttcgattat tgatggtgta acaaatgtac ttgcagagta tggtcgcata 14340
atagttcttg aagacgacat ggtcaccagt ccatattttc ttcaatacat gaatgatagc 14400
ttgagtcagt atgctgattt tcatgaagtt gcaagtattc atgcctatgt ttatcccatc 14460
gcaggattgc ccgatacttt ctttttgcgt ggtgcagatt gctggggctg ggctacatgg 14520
agggatagat gggattggtt tgaaccagat ggaagtaagt tgtttgcgca actgaagcag 14580
cttaacttgc tgaataagtt tgattataac ggtagttatc cattttcaaa tatgttgcgc 14640
gaccagattg caggaaccaa taattcttgg gcaatacgtt ggcatgctag tgctttcttg 14700
cttaataagt tgacgcttta tcctggtaaa gctttgctta gtaatattgg acatgatgga 14760
tccggtgtgc attgtggaga aagcgaaaca tactctgcgg agttgagagc tgaccgatta 14820
ctattgactg atattccatt gcgcgagtct gagccggcat ttaagaaatt tgagcaattt 14880
tttcttgaaa gcaaaccatc agttgttcgc aaaatgatgc tgaaggcaaa atccgtattt 14940
aaaaaatttt tatgagtttt atcaagatcc taaaattatt atgcccccca ctttttctgc 15000
atattctgca gaagtatagg cggcgtaact ttgcctcttc gttcgccgga aattattctt 15060
cttgggcgca tgctaaacaa aatagtggtg gctatgatgc ggaaaatatt ctcaccatca 15120
ttcaagagtc agctctcaaa gtcaagcgtg gtgaagcggt ttttgaacga gattcagtat 15180
gtttccatca tgttgagtat agatattccg ctttgtctgg attgctatac gcagctgtta 15240
gttctggtgg caagttgagt gtcctggatt ttggaggctc tctggcaagt ttttattctc 15300
agcatgctgc aatattgtct atagttaagg atttgcgttg gggagttgtt gagcagccac 15360
attttgttgc ctggggtcgc gagcacctaa ccacaactga tcttaaattt tacaatagcc 15420
tcacagagtt tattttggat ggaaaaccca atgttatttt tctttccagc gtcctgcaat 15480
atttggagca tccataccag ctgttagaag aattattgag gctagattct gagtttattc 15540
ttttcgatcg cacggctttt tatgacgttg ttgaccgctt aactgtccag acagtgcctg 15600
catcgattta tccggcaagt taccctgcct ggttcatttc ttgggacaaa tttataaata 15660
ctatgagtgc aggagggtat gaggtcatca tggagtttcc ttgtgcagac ctgacggaca 15720
taggctatta caaagggctt tttttcaagc gcaagagtgt aagttgattt tctaacaagc 15780
aattgttcat ctttgagtta ctgtgtctta tttcttctaa tgtacgggtt gattctcttg 15840
ttgtgaaatt gttaaggtaa ttgtatgaat gatgaactgt actcaggtaa gaatattctt 15900
gttactggtg gcttgggttt tattggttca aacttggtca aaagattaat tgcgcacaaa 15960
gccaaggtga ccgttgtaga tagcctgtta cctctttatg gtggcaatgc ctttaacctt 16020
agtggctatg aatcgctggt caatatcaac atcagcgatg tacgtgatag tcatgccatg 16080
gcttatctta tcaaaggcaa ggattacctt tttaaccttg ctggacaaac tagccatttg 16140
gattccatga ccgaccccag gacggatctg gatatcaatg ccgcagcaca attatccatt 16200
ctggaagcat gccgacagca taatcccgat gtcagaatag tcttcgctag caccagacag 16260
ctttatggca agcctgagta tttacctgta gatgagtcac acccgattca gccagtggat 16320
gtgaatggca tcaataaatt ggcaggggag tggtatcaca ttctctataa caatgtttac 16380
ggtatcaaag cctgtgcgct acgtctgaca aatacatatg gtcctggcat gcgcgtcaag 16440
gatgcccgtc agacttttct tgggatttgg ttgcgtagag tgattgaagg caagccaatt 16500
gcggtatttg gagatggctt gcaattgagg gatttcaatt acgttgatga tgtggtggat 16560
gctctgttac tggctgccgc caatacagaa gcagatgggc aaatatttaa tctcggcagt 16620
gatgaggttg taaatttaca gcaagtagct gaattaatga cacaatttca gcctggttcc 16680
agctatgaga ttgtgccatt cccacctgag agaaaagcca ttgatatcgg tgactactat 16740
agtgatttca ataaaatcaa gcaggtttta ggttggagcc cccgtgtggg cttgcaacaa 16800
gggcttgctg caagcctggc atactatcgc cagcatcatg ataaatattg ggacaacgta 16860
tgattttaat gaatgacttc aaggctgaac cagaagcttt gattgcagcg cagctgcaag 16920
ccgtcgagcg tgtgctgcgc tccggttggt atgtattagg tgaggagggg cgcaagtttg 16980
agtcattgtg gtctcagcgt tgcggcactt ctcatacagt gggtgttggc aatggcatgg 17040
atgcgattga gataggattg cgcgcgctgg acattgggcc cggtgatgag gtgattacca 17100
ctgcgatgac ggcttttgcc tctgtgctgg cgatcatacg tgcaggtgct acgccggtct 17160
tggccgatat tgatcctgac actggcttat tgagtcatga aagtgtcaag cgatgcatca 17220
actcgcgaac gaaagcggtc ttgctagtcc atctatacgg gcaaatcagg gatatgcaat 17280
cctggctgaa cttgtgcgat cagcatcaag tggctttgtt ggaagattgt gctcaagcac 17340
atttggcgca agcggaaggt aaagtggcgg ggagttttgg tcgctttggt gcttacagct 17400
tttatccgac caaaaacctg ggcgccattg gcgatggagg ggctttggta acatctcaat 17460
ctgcgctggc agacaaggct gcagtgttaa gaaattatgg ccaaagtgtg cgttaccatc 17520
atccagagtt tggcttgaat agtcgtcttg acgaaattca ggcggccttg ctcacggtaa 17580
ggctagagtg gctggaacaa tatacaagtc ataggcaatc aattgccgct caatacaggc 17640
agcagttgaa taatccatac gtgcgcctca tgcaaactcc aacagagcca ttagcccatg 17700
tctatcattt gtttgttgtg ctaacggagc accgtgaagc attgcaggct cacttgcagg 17760
caaatggcgt tcaggcattg attcattatc ctgtgcctat tcatcatcag gaaaagtgca 17820
gcgatatatt gagagatccg gctgggctgc aatttagtga ggcccatgca cagcaatgcc 17880
tttcgctgcc atgtcatcct caaatgtctg aacaagatgt tcagaccgtc attgctgcag 17940
tcaataggtt tgcactgtaa acatggagca ttttgtcaca ctgtttgata gcaagtttct 18000
gcctcaaggt ttgtgcctgc atgagtcgct ggcccgccat gccagggatt ttcatttatg 18060
gatagtctgt atggataaag tggtgcatga gcaactggaa aaattgcagt tgcctcatgt 18120
ttcgcttatg cgcttggccg attttgaaag cgaggcatta ttggccgtta aaccaggcag 18180
aacaaagggg gagtattgct ggaccataac cccattcact gccgaatggg tgtttgctca 18240
acacccagag gtggcacgag tcacttatct tgatgcagat ttattttttt tcaacgatcc 18300
tgcgatactt tttcatgagt ttgaacaaag cggcaagcat gtgatgatta ctgagcatgc 18360
atatgcaccc gattacattc agcatctgga aacgagtgga cggttttgtg tgcaattcat 18420
ggtatttgat cgaagtgaag catcccgtaa agttatgcat tggtggcaag atcgctgcgt 18480
ggagtggtgt tttgcaagga tggaggatgg aaagtttggt gatcagaaat atttagattt 18540
atggcctaca atttttgccg atgatgtcca catattgaag tgcgttgaac aaacgttggc 18600
accttggaat gtagactatc aacttcagca ccaaagtggg aaattcaagc cggtttttta 18660
ccactttcat gcattccgca taatcaagtt taatcttgtc agactttatg aagggtacca 18720
gatagctaaa agttctcgtt acctctatga cgagtatctt gcgactttgc agaaaaaaat 18780
tgggatgttg catcggtttg ccattccgtt gccattgttg ccagaaaaat gtggtattag 18840
gccaaaattg gcttcttatt acacatggat cagaggattt accgctacag ctaagatcaa 18900
ataaaatgca aaaacttagt gtgattacgg caacatataa tgccgctaaa aatttaccag 18960
atttagtgca aagcctgctt agtcaaactg atatggattt cgagtgggtc gttgcagatg 19020
gcggttcaag tgacgaaact atatcttatc taaaaagcgt tgtaggcatt aatcttttgc 19080
tgtcagcgca acaggatttt ggtatatacg atgcattaaa tcgtgcgatt tcgctaagct 19140
caggcgatta ttatttggtc ttgggtgccg atgatatttt gtatccacat gctgtcgagg 19200
cgtttaagcg tgcggctggc ataggtctgc ctgatctcgt caccgcaagt gtagagtcag 19260
atcatggtgt catgattgct ggaagtggca ggccattttt gcgcggacaa ttggcttata 19320
tttccaatca ttctgtcggt actatgatca aaaaaagttt gcatgatcgt tttggttatt 19380
actcccgccg attccctatc acggcagatc agtattttat caagcgtgtt tgtggcgcta 19440
gcgaaacggt gatttacaaa gcagattttg tagcaggcta ttatccagct acaggcgtgt 19500
caggagcaga tgtccctggg acgatggttg aatttttccg cgtgcaattg gaaaccgaac 19560
ctaattcagt gctccagcta gtacttttca ttttgcgttt gatacgccat acccccaagc 19620
tcatccggta tgcacactac aaaaaattgc gcgatctacc ccagcatgaa tagcaacgta 19680
ttgtttatca ctggctttca tcctggaggt atgggtttta ttggtgcagg tgaggcaatc 19740
agtcagcaac atatagagcg actgataaag caaggaagga aagtgcatgt gctggcactt 19800
gcccctaatt atcaagtcgc cagtcctgag gttgttgcaa gctgtgcttc ctacaccacg 19860
cttacgcata cgcgatggat gacgtttgca gctttatggc gctcacgcca gcagggaagt 19920
ctgctctgcc cctggttatt tacgcgtgta tcaccgcaag ctgaacgttt tatccgtcag 19980
ttgttggacc aacacgccat tactgagatc tatcttgatt ttccatcttg tcttggcttc 20040
gcgccaacat acaatcaatt acccattcat tacattgttc atgatgtgtt gtcgcaaaaa 20100
gttgagcgac gtcctttatt aaaatggctg aaaaatcaag tgttgcgcac ggaatcgtcc 20160
ctgctgcgtc atgtcaccca gtgtttcaca ctttccctga aggacaagct gagatgcgag 20220
gaaatagggt atagcggcca gatagaggtg caggtgccgc acattctcaa ggtaggggtt 20280
gttaatcaag gagtgccaat tgcagggatc ctcaagcaat ttcctggcaa gaaaaacctg 20340
gttttttttg gcaacatgca gcgggctgaa aatcattact ccatcttaag atttttgttg 20400
tgcagttatc ctggcatctg gttggagcat cgcgatgttc agtgctggat attaggtttg 20460
gcaccaagaa cgctattgcg ttggatatcg aaagtgttgc ctggtgttag agtcactggc 20520
gctgttgatg acccaactga ggcgtttaag gcggcaactt tatgtattgc acctgtatat 20580
tacggtgctg gtgtgaaaat caaagtttta caaatgctgg aatcgggagc cacagttata 20640
tcgacgccag tcggagctga gggtattcac ggcagtgaaa aactcattac ggtggaaagt 20700
gctcgtctat cctccactat caagcaacgt ttggcagttg aatcatgaat cagcatgaac 20760
tccccagcgt tgcagtgttg ttggccagtt tcaacggtag ggcttggata gcggagcagc 20820
ttgccagtat tcttgctcaa cagggtgtca agcttcatgt gtttattgcg gacgacttat 20880
ccactgatgg cacttgggag tggttgaatg tagaggctgc ttgtcatcaa aacgtgactt 20940
tgctgccaca taatcagcgt gcaggttctg cgggcaggaa tttttatcgt ttgatccacg 21000
aagttgatct ggatggtttc gatttcgttg catttgcaga tcaagatgat gtgtgggata 21060
gctataagtt gagcaggcat gcacgcttga tgaagctaca tcaggctgat ggtgtgtctt 21120
ccaatgttga ggcattttgg cctgacggca gagtgatgct gatcgttaaa tctcaagctc 21180
agcggcagtt tgattatctc ttcgaatctg ctgggccagg ttgtactttc ttgatgacta 21240
ctcgcctcgc acatcaagtg cgcaatgtgc tccaagatga gctatctcca gcgcgggatg 21300
ttactttgca tgattggcta acttatgcaa ttgcacgttc cttgggatat acctgggtga 21360
tagatgctaa cccttctctg aaatatcggc agcatggcaa taatgtgatt ggggccaatg 21420
tcagtcttaa agcgaaatgg acgagattga aacaaatccg cgatggctgg tatcgccagc 21480
aagtcattaa ggtgacacgc atcgcttatg ctttttctca gcgcgaagat ttgcagcgct 21540
tattggtttt gctggagaag ccttcacttg gaaaccgcct gcagttattg ccatatgcct 21600
ggcatggaag gcgatcagtg aaggatcgtt tattcctgat gtttagtatt gtgtttaagt 21660
ggttttgaac gatgagtcag caacatattt tggttaccgg agctaatggc tttgtgggtc 21720
gatcactatg caatcaatta tgccaatcag cctttcaagt cacccaggtt ggacgtgctc 21780
taaatagcgc tgatggggga gcatatagcc aggttgtgtc gatagatgga acaacggatt 21840
ggtcgaccat cttggatgag gttgaggtag tgatacatct tgctgccaga gttcatgtga 21900
tgcaggaaaa cttagttgat ccaatcgtgg cttactggca aaccaatgtc gagggcacct 21960
tgaatttggc caggcaagcg ctaaatgctg gggttaaacg ctttattttt gtaagttcca 22020
tcaaggttaa tggcgagcaa agtttcccag gcaaaccatt tactgcagaa gatatgccta 22080
tgccagaaga tgcctatggc aaatccaagt gggaggcgga gcagggcttg cttgcattgg 22140
caaaggattc aaatatggtt gtggtcatta ttcgcccacc tctggtttat ggtcccggtg 22200
taaaaggtaa tttttccacc atgatcaaac tgctgcagac aggcttgcca ttgcctttcg 22260
gggcgattgc caatcaacgg tctttggttg ctatcgataa tttgatccac ttaattatgg 22320
tgtgtattaa tcatccggcc gccgccaatc aggttttctt agtcagtgat ggtgaggatt 22380
tgtctactac cgctttattg cgtcgcttgg ctctagcggc tggcgtatca tctagattga 22440
ttccctttcc tgcagcatgg gtcaacttcg tctttactgt tctgggtaag aaaatgatgg 22500
cagggagaat tttagggtct ttgcaggtgg atatcagcaa gacacgcgag gtattaggct 22560
ggcagcctcc tgtgacagtt gatcaagggc tgcgaaattg ttttccaact aaggctgagc 22620
cgtgattcgt ttttttgaca ttgtattttc cttgcttggc ctggtattcg gtttgccatt 22680
attgataata atttatctgg tcggcttgct cgatacaggc tctcccttat tccgccaagt 22740
gagggtaggg cggcatcgcc agccatttac gctggtgaaa ttccgcacca tgaaagtcaa 22800
cacagcatca gttgccagtc atctggcttc tgccagctct attacttggt taggtagttt 22860
tttacgcagt acaaagttag atgaattgcc gcagctttgg aatgtgctca agggcgagat 22920
gagcttggtg gggccgcggc cgaatttgtt taatcaggat gagttgattg cagcgcgtga 22980
tgcacggggt gtttatgcag ttcgaccagg catcaccgga ctggctcagg tgaatgacat 23040
tgatatgtct atgccaaagt tgcttgcaga gacagatgct tctatgttgc agcaattaaa 23100
tttaaagctt tatttcaagc tgttaattca gactgtattg ggcaaggggc gtggtgacag 23160
ggtcgtgcgg tgatctaccg ccatgccagt taggcgagtg ctattttcgt tctgccaacg 23220
cagcactata gtttttcagt aaaatacatt tttttcattt taggccgtgc gcgtgcatac 23280
ccccccccat ttatttcgtt ggcctaattt catcagtttg aaaaacccgc gctcaatcag 23340
tgcctgggtg catgacatca ttgccgccat gcttgcgtgg tgggtagcat ttcttttccg 23400
cttcaatttt gatatccctg ccccatttgc cgagagcatg ttgcaaagtg cagcttgggt 23460
tattcccctg caagcaacat ttttcctgct atgcggcctt taccgcggtg tatggcgttt 23520
tgccagtctg ccggatttac agcggctgat tcgagcgatt ggggtggccg cagtagttgt 23580
ggtagcaatt ttgtttatgt tccagccaca tggggttgtg ccgcgctcgg tgttgatcat 23640
gaatcccatg ctgctgcttt tgttgatggg tggcagccgc attgcctacc gcgcctggaa 23700
agagcatcga ctgtatggcg cggcccaatc ctcaggtaag ccagtgttgg tgcttggcgc 23760
cggggatgcc gcgattgcct tgctcaagga tttatccaag agtcatgagt ggcgcatagt 23820
gggcttgctt gatgataagc aatcaatgtt cggccgtgag ttgcttggtg taaaagtgct 23880
aggcaaactc agcgattttc ctgagatcgc caaggcaatg tctgttcagc atgtgattgt 23940
ggccattcct tcggcgcgca acaacgcagg cgccagatta ttgatatggc cagtcagcac 24000
aaactcaagg tacttaccgt gccatcactg gaagatttga tgagtgggcg tgtcagcatg 24060
gcgcagctac gtccggttga ggttgaagat ttgcttgggc gtgagcctgt ggtgttggac 24120
gatgatggtt tgcaccagtt gatcgatagt caggtggtta tggtcactgg cgcgggcggc 24180
tcgattggtt cagaactttg ccgacagtta ctcaagtttc agccttcaat gctggtgtgt 24240
ttcgaccatt cggagttttc tctttatagc ctagagcaag aactgaccgc tttaaagctg 24300
gatgtgcgga ttgaatatct ggtaggggac gtcaagaatg cacgacgcgt gcagcacgtg 24360
cttgctagtt atcagccagc acagtatttc atgctgcagc ctataaacat gtgcctatga 24420
tggaaaaccg taacgttgca gagtcattat ccaataatgt gctgggtact ttcacagtag 24480
ccagtgcatg taaggcggcg ggcgttaata agtttgtgct ggtatccaca gataaagcgg 24540
ttaacccaac caatgtcatg ggggctagca aacgtctggc tgaaatggtg tgtcaaggtt 24600
tgcaggcgga aacaggaacc cgctttgtgg tagtgcgttt cggcaatgtg ctgggcagca 24660
gtggtagtgt gatccctaag tttaaagagc aaattgcgct tggtgggcca gtcaccgtta 24720
ctcatcccga gatcacgcgt tatttcatgt ctatacctga ggcgtgccag ttggtcatgc 24780
aagccggatt gatgggtaag ggcggagaaa tattcgtgct agatatgggt gaccccatca 24840
agattgtgga cttggcgcgt gctatgatta ggttgtcagg gttgggggat gatgaggtcg 24900
acattgtttt ttccggcctg cgccctggcg agaagctgta cgaggaactt ttggcagacg 24960
acgaactcac tttaccgacg ccgcacgata aattgcgtat cgccgtggct agaagtgcag 25020
atgaggcctg ggttgtggct ttgctcaagt gggtagacaa gtcatccagc atggatgagg 25080
cagtcgtgaa gcaagagctc aagatgtggg tggaggagta tgcaggtgat atacatgcta 25140
gtctttcttc tgcgttgact cccgggtcat cgacaataca ttaaaagaaa gacgattgag 25200
atgacaaaaa aaattaccaa ggcagtcttc cccgtggcag gtcttggcac gcgtttcttg 25260
ccggccacca aagccagccc caaagagatg ctgcctatcg ttgataaacc tctgattcag 25320
tatgccgcgg aagaagcagt tgctgctggt gcaactgaac tgatctttat tattggtcgc 25380
aataagcgct ccattcctga tcattttgac aagtcttttg aacttgaagc ttccctagaa 25440
gccagcaaga aaaccaagat gcttgaggaa attcagaaca ttctacccaa gcacgtttcc 25500
tgcatttata tccgtcaagc tgaagctttg ggcttgggcc acgcggtgtt gctggctaaa 25560
tctgtcgtgg gtaatgaacc gttctctgtc attttggcag atgacttgat tgatgctgaa 25620
aagcctgcga tgcaacaaat gactgagttg tttgaaaagc aaggagcttc aattcttggt 25680
gttgaagatg ttgagccaag cgagacagca agctacggta ttgttgatgc agtggaattg 25740
acaggcccag atgtattgca gctgaacggc attgttgaaa agccacagcc tgaagatgca 25800
ccttctaacc tggcggtggt tggacgttat attttgactc ctgaaatctt cacctgcctt 25860
gagaatgtca agccaggtaa gggtggggaa attcaattga ccgatggtat tgctgcgctg 25920
atggagcaac aaaagattct ggcttatcgc ttcaagggta agcgttacga ctgcggcagc 25980
aagttgggct atgtcaaagc caatgtcgag ttttcgctta agcatgaaga aattggtgag 26040
gagttctcgc agtatctgcg tgaattgacc aagtaa 26076
<210> 180
<211> 26076
<212> DNA
<213> 糖原甲基菌
<400> 180
ttacttggtc aattcacgca gatactgcga gaactcctca ccaatttctt catgcttaag 60
cgaaaactcg acattggctt tgacatagcc caacttgctg ccgcagtcgt aacgcttacc 120
cttgaagcga taagccagaa tcttttgttg ctccatcagc gcagcaatac catcggtcaa 180
ttgaatttcc ccacccttac ctggcttgac attctcaagg caggtgaaga tttcaggagt 240
caaaatataa cgtccaacca ccgccaggtt agaaggtgca tcttcaggct gtggcttttc 300
aacaatgccg ttcagctgca atacatctgg gcctgtcaat tccactgcat caacaatacc 360
gtagcttgct gtctcgcttg gctcaacatc ttcaacacca agaattgaag ctccttgctt 420
ttcaaacaac tcagtcattt gttgcatcgc aggcttttca gcatcaatca agtcatctgc 480
caaaatgaca gagaacggtt cattacccac gacagattta gccagcaaca ccgcgtggcc 540
caagcccaaa gcttcagctt gacggatata aatgcaggaa acgtgcttgg gtagaatgtt 600
ctgaatttcc tcaagcatct tggttttctt gctggcttct agggaagctt caagttcaaa 660
agacttgtca aaatgatcag gaatggagcg cttattgcga ccaataataa agatcagttc 720
agttgcacca gcagcaactg cttcttccgc ggcatactga atcagaggtt tatcaacgat 780
aggcagcatc tctttggggc tggctttggt ggccggcaag aaacgcgtgc caagacctgc 840
cacggggaag actgccttgg taattttttt tgtcatctca atcgtctttc ttttaatgta 900
ttgtcgatga cccgggagtc aacgcagaag aaagactagc atgtatatca cctgcatact 960
cctccaccca catcttgagc tcttgcttca cgactgcctc atccatgctg gatgacttgt 1020
ctacccactt gagcaaagcc acaacccagg cctcatctgc acttctagcc acggcgatac 1080
gcaatttatc gtgcggcgtc ggtaaagtga gttcgtcgtc tgccaaaagt tcctcgtaca 1140
gcttctcgcc agggcgcagg ccggaaaaaa caatgtcgac ctcatcatcc cccaaccctg 1200
acaacctaat catagcacgc gccaagtcca caatcttgat ggggtcaccc atatctagca 1260
cgaatatttc tccgccctta cccatcaatc cggcttgcat gaccaactgg cacgcctcag 1320
gtatagacat gaaataacgc gtgatctcgg gatgagtaac ggtgactggc ccaccaagcg 1380
caatttgctc tttaaactta gggatcacac taccactgct gcccagcaca ttgccgaaac 1440
gcactaccac aaagcgggtt cctgtttccg cctgcaaacc ttgacacacc atttcagcca 1500
gacgtttgct agcccccatg acattggttg ggttaaccgc tttatctgtg gataccagca 1560
caaacttatt aacgcccgcc gccttacatg cactggctac tgtgaaagta cccagcacat 1620
tattggataa tgactctgca acgttacggt tttccatcat aggcacatgt ttataggctg 1680
cagcatgaaa tactgtgctg gctgataact agcaagcacg tgctgcacgc gtcgtgcatt 1740
cttgacgtcc cctaccagat attcaatccg cacatccagc tttaaagcgg tcagttcttg 1800
ctctaggcta taaagagaaa actccgaatg gtcgaaacac accagcattg aaggctgaaa 1860
cttgagtaac tgtcggcaaa gttctgaacc aatcgagccg cccgcgccag tgaccataac 1920
cacctgacta tcgatcaact ggtgcaaacc atcatcgtcc aacaccacag gctcacgccc 1980
aagcaaatct tcaacctcaa ccggacgtag ctgcgccatg ctgacacgcc cactcatcaa 2040
atcttccagt gatggcacgg taagtacctt gagtttgtgc tgactggcca tatcaataat 2100
ctggcgcctg cgttgttgcg cgccgaagga atggccacaa tcacatgctg aacagacatt 2160
gccttggcga tctcaggaaa atcgctgagt ttgcctagca cttttacacc aagcaactca 2220
cggccgaaca ttgattgctt atcatcaagc aagcccacta tgcgccactc atgactcttg 2280
gataaatcct tgagcaaggc aatcgcggca tccccggcgc caagcaccaa cactggctta 2340
cctgaggatt gggccgcgcc atacagtcga tgctctttcc aggcgcggta ggcaatgcgg 2400
ctgccaccca tcaacaaaag cagcagcatg ggattcatga tcaacaccga gcgcggcaca 2460
accccatgtg gctggaacat aaacaaaatt gctaccacaa ctactgcggc caccccaatc 2520
gctcgaatca gccgctgtaa atccggcaga ctggcaaaac gccatacacc gcggtaaagg 2580
ccgcatagca ggaaaaatgt tgcttgcagg ggaataaccc aagctgcact ttgcaacatg 2640
ctctcggcaa atggggcagg gatatcaaaa ttgaagcgga aaagaaatgc tacccaccac 2700
gcaagcatgg cggcaatgat gtcatgcacc caggcactga ttgagcgcgg gtttttcaaa 2760
ctgatgaaat taggccaacg aaataaatgg gggggggtat gcacgcgcac ggcctaaaat 2820
gaaaaaaatg tattttactg aaaaactata gtgctgcgtt ggcagaacga aaatagcact 2880
cgcctaactg gcatggcggt agatcaccgc acgaccctgt caccacgccc cttgcccaat 2940
acagtctgaa ttaacagctt gaaataaagc tttaaattta attgctgcaa catagaagca 3000
tctgtctctg caagcaactt tggcatagac atatcaatgt cattcacctg agccagtccg 3060
gtgatgcctg gtcgaactgc ataaacaccc cgtgcatcac gcgctgcaat caactcatcc 3120
tgattaaaca aattcggccg cggccccacc aagctcatct cgcccttgag cacattccaa 3180
agctgcggca attcatctaa ctttgtactg cgtaaaaaac tacctaacca agtaatagag 3240
ctggcagaag ccagatgact ggcaactgat gctgtgttga ctttcatggt gcggaatttc 3300
accagcgtaa atggctggcg atgccgccct accctcactt ggcggaataa gggagagcct 3360
gtatcgagca agccgaccag ataaattatt atcaataatg gcaaaccgaa taccaggcca 3420
agcaaggaaa atacaatgtc aaaaaaacga atcacggctc agccttagtt ggaaaacaat 3480
ttcgcagccc ttgatcaact gtcacaggag gctgccagcc taatacctcg cgtgtcttgc 3540
tgatatccac ctgcaaagac cctaaaattc tccctgccat cattttctta cccagaacag 3600
taaagacgaa gttgacccat gctgcaggaa agggaatcaa tctagatgat acgccagccg 3660
ctagagccaa gcgacgcaat aaagcggtag tagacaaatc ctcaccatca ctgactaaga 3720
aaacctgatt ggcggcggcc ggatgattaa tacacaccat aattaagtgg atcaaattat 3780
cgatagcaac caaagaccgt tgattggcaa tcgccccgaa aggcaatggc aagcctgtct 3840
gcagcagttt gatcatggtg gaaaaattac cttttacacc gggaccataa accagaggtg 3900
ggcgaataat gaccacaacc atatttgaat cctttgccaa tgcaagcaag ccctgctccg 3960
cctcccactt ggatttgcca taggcatctt ctggcatagg catatcttct gcagtaaatg 4020
gtttgcctgg gaaactttgc tcgccattaa ccttgatgga acttacaaaa ataaagcgtt 4080
taaccccagc atttagcgct tgcctggcca aattcaaggt gccctcgaca ttggtttgcc 4140
agtaagccac gattggatca actaagtttt cctgcatcac atgaactctg gcagcaagat 4200
gtatcactac ctcaacctca tccaagatgg tcgaccaatc cgttgttcca tctatcgaca 4260
caacctggct atatgctccc ccatcagcgc tatttagagc acgtccaacc tgggtgactt 4320
gaaaggctga ttggcataat tgattgcata gtgatcgacc cacaaagcca ttagctccgg 4380
taaccaaaat atgttgctga ctcatcgttc aaaaccactt aaacacaata ctaaacatca 4440
ggaataaacg atccttcact gatcgccttc catgccaggc atatggcaat aactgcaggc 4500
ggtttccaag tgaaggcttc tccagcaaaa ccaataagcg ctgcaaatct tcgcgctgag 4560
aaaaagcata agcgatgcgt gtcaccttaa tgacttgctg gcgataccag ccatcgcgga 4620
tttgtttcaa tctcgtccat ttcgctttaa gactgacatt ggccccaatc acattattgc 4680
catgctgccg atatttcaga gaagggttag catctatcac ccaggtatat cccaaggaac 4740
gtgcaattgc ataagttagc caatcatgca aagtaacatc ccgcgctgga gatagctcat 4800
cttggagcac attgcgcact tgatgtgcga ggcgagtagt catcaagaaa gtacaacctg 4860
gcccagcaga ttcgaagaga taatcaaact gccgctgagc ttgagattta acgatcagca 4920
tcactctgcc gtcaggccaa aatgcctcaa cattggaaga cacaccatca gcctgatgta 4980
gcttcatcaa gcgtgcatgc ctgctcaact tatagctatc ccacacatca tcttgatctg 5040
caaatgcaac gaaatcgaaa ccatccagat caacttcgtg gatcaaacga taaaaattcc 5100
tgcccgcaga acctgcacgc tgattatgtg gcagcaaagt cacgttttga tgacaagcag 5160
cctctacatt caaccactcc caagtgccat cagtggataa gtcgtccgca ataaacacat 5220
gaagcttgac accctgttga gcaagaatac tggcaagctg ctccgctatc caagccctac 5280
cgttgaaact ggccaacaac actgcaacgc tggggagttc atgctgattc atgattcaac 5340
tgccaaacgt tgcttgatag tggaggatag acgagcactt tccaccgtaa tgagtttttc 5400
actgccgtga ataccctcag ctccgactgg cgtcgatata actgtggctc ccgattccag 5460
catttgtaaa actttgattt tcacaccagc accgtaatat acaggtgcaa tacataaagt 5520
tgccgcctta aacgcctcag ttgggtcatc aacagcgcca gtgactctaa caccaggcaa 5580
cactttcgat atccaacgca atagcgttct tggtgccaaa cctaatatcc agcactgaac 5640
atcgcgatgc tccaaccaga tgccaggata actgcacaac aaaaatctta agatggagta 5700
atgattttca gcccgctgca tgttgccaaa aaaaaccagg tttttcttgc caggaaattg 5760
cttgaggatc cctgcaattg gcactccttg attaacaacc cctaccttga gaatgtgcgg 5820
cacctgcacc tctatctggc cgctataccc tatttcctcg catctcagct tgtccttcag 5880
ggaaagtgtg aaacactggg tgacatgacg cagcagggac gattccgtgc gcaacacttg 5940
atttttcagc cattttaata aaggacgtcg ctcaactttt tgcgacaaca catcatgaac 6000
aatgtaatga atgggtaatt gattgtatgt tggcgcgaag ccaagacaag atggaaaatc 6060
aagatagatc tcagtaatgg cgtgttggtc caacaactga cggataaaac gttcagcttg 6120
cggtgataca cgcgtaaata accaggggca gagcagactt ccctgctggc gtgagcgcca 6180
taaagctgca aacgtcatcc atcgcgtatg cgtaagcgtg gtgtaggaag cacagcttgc 6240
aacaacctca ggactggcga cttgataatt aggggcaagt gccagcacat gcactttcct 6300
tccttgcttt atcagtcgct ctatatgttg ctgactgatt gcctcacctg caccaataaa 6360
acccatacct ccaggatgaa agccagtgat aaacaatacg ttgctattca tgctggggta 6420
gatcgcgcaa ttttttgtag tgtgcatacc ggatgagctt gggggtatgg cgtatcaaac 6480
gcaaaatgaa aagtactagc tggagcactg aattaggttc ggtttccaat tgcacgcgga 6540
aaaattcaac catcgtccca gggacatctg ctcctgacac gcctgtagct ggataatagc 6600
ctgctacaaa atctgctttg taaatcaccg tttcgctagc gccacaaaca cgcttgataa 6660
aatactgatc tgccgtgata gggaatcggc gggagtaata accaaaacga tcatgcaaac 6720
tttttttgat catagtaccg acagaatgat tggaaatata agccaattgt ccgcgcaaaa 6780
atggcctgcc acttccagca atcatgacac catgatctga ctctacactt gcggtgacga 6840
gatcaggcag acctatgcca gccgcacgct taaacgcctc gacagcatgt ggatacaaaa 6900
tatcatcggc acccaagacc aaataataat cgcctgagct tagcgaaatc gcacgattta 6960
atgcatcgta tataccaaaa tcctgttgcg ctgacagcaa aagattaatg cctacaacgc 7020
tttttagata agatatagtt tcgtcacttg aaccgccatc tgcaacgacc cactcgaaat 7080
ccatatcagt ttgactaagc aggctttgca ctaaatctgg taaattttta gcggcattat 7140
atgttgccgt aatcacacta agtttttgca ttttatttga tcttagctgt agcggtaaat 7200
cctctgatcc atgtgtaata agaagccaat tttggcctaa taccacattt ttctggcaac 7260
aatggcaacg gaatggcaaa ccgatgcaac atcccaattt ttttctgcaa agtcgcaaga 7320
tactcgtcat agaggtaacg agaactttta gctatctggt acccttcata aagtctgaca 7380
agattaaact tgattatgcg gaatgcatga aagtggtaaa aaaccggctt gaatttccca 7440
ctttggtgct gaagttgata gtctacattc caaggtgcca acgtttgttc aacgcacttc 7500
aatatgtgga catcatcggc aaaaattgta ggccataaat ctaaatattt ctgatcacca 7560
aactttccat cctccatcct tgcaaaacac cactccacgc agcgatcttg ccaccaatgc 7620
ataactttac gggatgcttc acttcgatca aataccatga attgcacaca aaaccgtcca 7680
ctcgtttcca gatgctgaat gtaatcgggt gcatatgcat gctcagtaat catcacatgc 7740
ttgccgcttt gttcaaactc atgaaaaagt atcgcaggat cgttgaaaaa aaataaatct 7800
gcatcaagat aagtgactcg tgccacctct gggtgttgag caaacaccca ttcggcagtg 7860
aatggggtta tggtccagca atactccccc tttgttctgc ctggtttaac ggccaataat 7920
gcctcgcttt caaaatcggc caagcgcata agcgaaacat gaggcaactg caatttttcc 7980
agttgctcat gcaccacttt atccatacag actatccata aatgaaaatc cctggcatgg 8040
cgggccagcg actcatgcag gcacaaacct tgaggcagaa acttgctatc aaacagtgtg 8100
acaaaatgct ccatgtttac agtgcaaacc tattgactgc agcaatgacg gtctgaacat 8160
cttgttcaga catttgagga tgacatggca gcgaaaggca ttgctgtgca tgggcctcac 8220
taaattgcag cccagccgga tctctcaata tatcgctgca cttttcctga tgatgaatag 8280
gcacaggata atgaatcaat gcctgaacgc catttgcctg caagtgagcc tgcaatgctt 8340
cacggtgctc cgttagcaca acaaacaaat gatagacatg ggctaatggc tctgttggag 8400
tttgcatgag gcgcacgtat ggattattca actgctgcct gtattgagcg gcaattgatt 8460
gcctatgact tgtatattgt tccagccact ctagccttac cgtgagcaag gccgcctgaa 8520
tttcgtcaag acgactattc aagccaaact ctggatgatg gtaacgcaca ctttggccat 8580
aatttcttaa cactgcagcc ttgtctgcca gcgcagattg agatgttacc aaagcccctc 8640
catcgccaat ggcgcccagg tttttggtcg gataaaagct gtaagcacca aagcgaccaa 8700
aactccccgc cactttacct tccgcttgcg ccaaatgtgc ttgagcacaa tcttccaaca 8760
aagccacttg atgctgatcg cacaagttca gccaggattg catatccctg atttgcccgt 8820
atagatggac tagcaagacc gctttcgttc gcgagttgat gcatcgcttg acactttcat 8880
gactcaataa gccagtgtca ggatcaatat cggccaagac cggcgtagca cctgcacgta 8940
tgatcgccag cacagaggca aaagccgtca tcgcagtggt aatcacctca tcaccgggcc 9000
caatgtccag cgcgcgcaat cctatctcaa tcgcatccat gccattgcca acacccactg 9060
tatgagaagt gccgcaacgc tgagaccaca atgactcaaa cttgcgcccc tcctcaccta 9120
atacatacca accggagcgc agcacacgct cgacggcttg cagctgcgct gcaatcaaag 9180
cttctggttc agccttgaag tcattcatta aaatcatacg ttgtcccaat atttatcatg 9240
atgctggcga tagtatgcca ggcttgcagc aagcccttgt tgcaagccca cacgggggct 9300
ccaacctaaa acctgcttga ttttattgaa atcactatag tagtcaccga tatcaatggc 9360
ttttctctca ggtgggaatg gcacaatctc atagctggaa ccaggctgaa attgtgtcat 9420
taattcagct acttgctgta aatttacaac ctcatcactg ccgagattaa atatttgccc 9480
atctgcttct gtattggcgg cagccagtaa cagagcatcc accacatcat caacgtaatt 9540
gaaatccctc aattgcaagc catctccaaa taccgcaatt ggcttgcctt caatcactct 9600
acgcaaccaa atcccaagaa aagtctgacg ggcatccttg acgcgcatgc caggaccata 9660
tgtatttgtc agacgtagcg cacaggcttt gataccgtaa acattgttat agagaatgtg 9720
ataccactcc cctgccaatt tattgatgcc attcacatcc actggctgaa tcgggtgtga 9780
ctcatctaca ggtaaatact caggcttgcc ataaagctgt ctggtgctag cgaagactat 9840
tctgacatcg ggattatgct gtcggcatgc ttccagaatg gataattgtg ctgcggcatt 9900
gatatccaga tccgtcctgg ggtcggtcat ggaatccaaa tggctagttt gtccagcaag 9960
gttaaaaagg taatccttgc ctttgataag ataagccatg gcatgactat cacgtacatc 10020
gctgatgttg atattgacca gcgattcata gccactaagg ttaaaggcat tgccaccata 10080
aagaggtaac aggctatcta caacggtcac cttggctttg tgcgcaatta atcttttgac 10140
caagtttgaa ccaataaaac ccaagccacc agtaacaaga atattcttac ctgagtacag 10200
ttcatcattc atacaattac cttaacaatt tcacaacaag agaatcaacc cgtacattag 10260
aagaaataag acacagtaac tcaaagatga acaattgctt gttagaaaat caacttacac 10320
tcttgcgctt gaaaaaaagc cctttgtaat agcctatgtc cgtcaggtct gcacaaggaa 10380
actccatgat gacctcatac cctcctgcac tcatagtatt tataaatttg tcccaagaaa 10440
tgaaccaggc agggtaactt gccggataaa tcgatgcagg cactgtctgg acagttaagc 10500
ggtcaacaac gtcataaaaa gccgtgcgat cgaaaagaat aaactcagaa tctagcctca 10560
ataattcttc taacagctgg tatggatgct ccaaatattg caggacgctg gaaagaaaaa 10620
taacattggg ttttccatcc aaaataaact ctgtgaggct attgtaaaat ttaagatcag 10680
ttgtggttag gtgctcgcga ccccaggcaa caaaatgtgg ctgctcaaca actccccaac 10740
gcaaatcctt aactatagac aatattgcag catgctgaga ataaaaactt gccagagagc 10800
ctccaaaatc caggacactc aacttgccac cagaactaac agctgcgtat agcaatccag 10860
acaaagcgga atatctatac tcaacatgat ggaaacatac tgaatctcgt tcaaaaaccg 10920
cttcaccacg cttgactttg agagctgact cttgaatgat ggtgagaata ttttccgcat 10980
catagccacc actattttgt ttagcatgcg cccaagaaga ataatttccg gcgaacgaag 11040
aggcaaagtt acgccgccta tacttctgca gaatatgcag aaaaagtggg gggcataata 11100
attttaggat cttgataaaa ctcataaaaa ttttttaaat acggattttg ccttcagcat 11160
cattttgcga acaactgatg gtttgctttc aagaaaaaat tgctcaaatt tcttaaatgc 11220
cggctcagac tcgcgcaatg gaatatcagt caatagtaat cggtcagctc tcaactccgc 11280
agagtatgtt tcgctttctc cacaatgcac accggatcca tcatgtccaa tattactaag 11340
caaagcttta ccaggataaa gcgtcaactt attaagcaag aaagcactag catgccaacg 11400
tattgcccaa gaattattgg ttcctgcaat ctggtcgcgc aacatatttg aaaatggata 11460
actaccgtta taatcaaact tattcagcaa gttaagctgc ttcagttgcg caaacaactt 11520
acttccatct ggttcaaacc aatcccatct atccctccat gtagcccagc cccagcaatc 11580
tgcaccacgc aaaaagaaag tatcgggcaa tcctgcgatg ggataaacat aggcatgaat 11640
acttgcaact tcatgaaaat cagcatactg actcaagcta tcattcatgt attgaagaaa 11700
atatggactg gtgaccatgt cgtcttcaag aactattatg cgaccatact ctgcaagtac 11760
atttgttaca ccatcaataa tcgaagcagc tagcccaaaa ttcgtttgac gttctatgat 11820
tcttactgac ttgaagcctt caacagtgtg agtaaacgct ctgacagcat ccaccatgct 11880
ttgctgtgta atattttttg cagcatcaga aaaaatcagc aagtccgttt cagcagacaa 11940
ggtattattc ttcagtgctt caatcgtcct tttagtatgg tcagggcggt tataagtaaa 12000
cagggcaaca ggtgctagat tggacatggt tacttacagt ttcaaaagat cttgataaaa 12060
ctcagtgttg aatgtacgcg ctatgacttt gtaatgattt tgaatcatga aactgcgtat 12120
gcgttcgcca gcgacatcat caagtgcttc tgccagaact atacgaggcc tgtactttga 12180
ccagtcgtta gaggcaagca cttggtaatc aaagccttca acatctatac tcatgaaatc 12240
aatttcagta tccggcagca gcacttcatc caaaatttta gtcaagggtc ttactggcac 12300
cttgcgggta ccgacgcgtt tataagcagt gttttgtata cgctgattgg ccaattcctc 12360
actgaaggta ttgagagcag gctcatcgaa catatgataa gtcagctcag actcatgatc 12420
agataccccc atttccaagg caatatctgc tgggcgccgt gttttaaaca aagcaatagc 12480
ctcgtgtgag ggatctatac aaactcccct ccaaccacgt ttataaaata aataagtatt 12540
ggagaacctt actgggtgat gagcacctat atcaatataa tacccagtag aggttcggtc 12600
aaaaattcta ctcagaatta aatcttcccc ctcttgcgca taagagaatt tatataagcc 12660
tctatcccgg taaaatgaaa aaatctcttg cgaataatta aatattttta aagcaatact 12720
tgagatagac ataaatttat actttattga ttaatgccaa atcaactgta tgatcgactt 12780
gagacatgat ataaggatca tgactgacaa atataatgat cttattttca tactcattca 12840
taagattccg tatcacaatt tcttgtgtag ccttatctaa agctgttgta ctttcatcaa 12900
gtatcagcac attaggtttg cgcactaatg ctctggcaat agctatacgc tgacgctgcc 12960
cacctgaaag attttttcct tgatattgca aacgtgtttc ataaccttgc gcaagacttt 13020
ccacatcttt agaaatacaa gctaattcgc aagcccattt tacgtcctct agagtaaaag 13080
tctcgcccat acaaatattg ttgtagaccg tatcatcaaa aatcgcaggt tcttgattaa 13140
taagtacaat agaatgcctg atatgtgctc cagggatatt ttctgttgaa ataccatcta 13200
ttgaaatact gcctgaagca ggaggataaa acttcagcaa aacatccagc aaagtagact 13260
ttcctaaacc agatttcccc actaaagcat aagagttgtt cttttcaaac tcgtagtaaa 13320
cagaattgag aaccgctggc cttacgcctt gaacatcacg gtatgaaaac gacaaattat 13380
caatcttgat tgtatctatc ttgtgtaaat agttgtctga attagcgctc tcggcacttt 13440
catcggaaac taattccgtc acatcttttc ccgatttcgc atctgcaaca atgcgaacag 13500
ctagagtgat actctgacca acaactggga aaaatcgcat gagataagct atcaatgaca 13560
caatgtaagc catccctaag ttttcaacag aaacccagcc actcaatatc aaagccaaag 13620
atccgagtaa tagaaatatt attggtacta acttcgtagc cagatttatt gcatcaaggt 13680
aaaaaagaat atttgcatac gtaaaaatct ttcgcctata caaaccggca acatacttct 13740
cggaagaaag tgatcttact gctttgatat tgttcatcgc atccatgaaa atggaatttg 13800
ctttccttga accttctatt tgcctcacgc ccatcttatg agatattttt aaaatccaaa 13860
tgaagaatac ggcagacaca agcattaaaa tgaaaatcat ttcggcggca tatagtgaat 13920
aaattgcaat agaaataaaa tacattaccc ccagtaaaaa tgttgcaaca aactgagtca 13980
atgcaacaac cagagtactc gccctgaagg attcatctcc agcaagcccc ataaaaaaac 14040
ctatactttt ttcagatatt ttatcaattg acatcgaagt aatgattttt tcaaaagccc 14100
tagaaccgag ctgagccatc acacgtcttc caaggtagtg cgtcaggctt tgactaaata 14160
gttgcgtgac tactctcaaa gtgaacaata agaagaaaac ttgcaaaagg ctggcagcat 14220
caactgtaaa ccccaatata atcagagctt ttgaaatcaa accatgctta tctactgttt 14280
ctcctgaaac aagttcaaat aaaggcaata ggcttgccat tgccaacaat tcaataccta 14340
tagaaagtat agaaattaaa acactcaaat acaacaatgg gttgttattg aaagcaaatt 14400
ttaataactt aaaaatatat tttgcttgtg gcaatttatt caacaacttt cattttaatg 14460
gtaagtgtta ctaaatataa attgtattaa atatcagata attaacttat atcgaatgtt 14520
gttttaccgt agcttcaatt tcataatcgg aaacagcatc gaccacatca gatattacac 14580
cctcaaaaag gctagattga ttattaagaa ccagacttaa aaatcttaaa cggtctgtgt 14640
cgttggactg gacattccat acgtcgtagc tttttcgcaa attaactgaa aacttgttag 14700
ccaccctttt caatattcta tacgccggct tatccggcca actcagacca atctccagtg 14760
gctgattaac tctgacagtg cccagtgaaa aactgaccgc gagccagcga taggcattaa 14820
ctacatgtgt attatctgtt gatgttgcca aagaaagtac tttgataagg ttgtcataat 14880
actcatgttc agactctccc gttagatgta tatccgccgg ataggaaggt aagtatttat 14940
cataggtaat cacaggtatg ccatgtagca atgcttctac accagtggca gaccaccctg 15000
ttaccagcgc atgtacatca tcgagaaaat cgtataaaga aatattctga tctggtgagt 15060
ttaatttaac attctcaggg agatcctgaa gtattttttc ccaaatcaat gcttgctcag 15120
actgattgga atcgcgttta ttaggatagt ctcgcggatg tactctaatt acaagatagt 15180
catcaggcct agacttcata aaattaattg tacacttaat ccattcaaac tgatctgaga 15240
aaaccggact tttaacttta cgctcaggaa aacctttgat aacaaaagcc gcatacgctt 15300
catcaaaact acttaatgag gcgagtagaa ttttagcatt ctgtggaata ttgaattttt 15360
cacggattga aaaatttcct gtttttggcg ctgaaaaaac agcaaaagat ttacctttga 15420
ataattcgtg aatatgtgca gagactctat caatatcttc aagcgttact aaatttttaa 15480
cagcttgcca atgctgcaat gcagggttta ctaatttaaa tttactccac tcccacaccc 15540
ttaaagcact atatcgttca gcattgctag agctaccttc tataaaatat gcctgtctcc 15600
cctgttttac tgcatattct gcacacacac cattaacacc atactgtgga ctataaaaga 15660
aaattttttc tggacactct tgtttgaata tttggataaa accgattaac gataccaggg 15720
cattcctaag gtgaatctgt agatcttgcc attgttcatc tctaaattcc aaagacattt 15780
tcttatactt aagaagtggc tcatatgtag ccaaacgccc tactggtata tcttcataat 15840
gaaattcgag gaaattatct tccgtgacac ttttcaatag gttatcaatc agagcattag 15900
ttttctgatc aatataatca tgcaatttaa gatgcttgca atcaaaagac ttggttattt 15960
tattggcgtt attaatacat aactcacaaa ttgcactttt ctttttaaaa tcctcattca 16020
atgcaagatt gaaagcactc ataccagtgc aataatgagt aaagctttta tcacaggtca 16080
catatactaa ctcatggccg gcattactca gctgtgatgc caaccggctt tcaggaagcg 16140
catgtaacca aatagctgca tgcaaagaat aaaacatggc tttcatactt ttacttttct 16200
caacaacctg tgataggtca aacgtaaatt agctggacgc tctacccatt ttccaatata 16260
aattgacata gttaagatga ttattagcga taatgatgac atcaactctc tagtcaggct 16320
accgtacaca tcaaagttat atgagaagat ggcgtacgat agtaacaaca tagggaaatg 16380
gacaatatat aaagtgtacg aagtattggc caaaatattc attgccttaa tttctggcac 16440
tttgcatttt attgctgcca aaaataaaga atatacaaat ataacttgca ctggcaaaga 16500
aacgaacttc tgtccaatca ctgccatagc aaacaccaca atagccatta caacaaccaa 16560
agtcatgaac tttatgaaat ttcgacgata taagaaaatt acaccaccgc tcaaccacca 16620
taagccataa taaatatcgg tttttgtatt aaaaaacaag aatacagata atacgagaaa 16680
accagtatta gcaataaaat tgagcaaatt tttttgttta taatgaataa aaattattac 16740
aactaaacaa gcataaaaat atagcttagc ctcaatgcat aaactccata atggcccatt 16800
catttgcaac aagccattat tcatcaataa agaattgaca atgtctcgcg taccaatgct 16860
caagtagtct cttgcctgat agatatctcc tggtgccttt aaagtaccca ctgatcccgg 16920
tagttcaaag atcacaatca cactataggc aactaaagat attattatgc ttacaatgag 16980
aggaggatat atgcgcaata atctgctaga tgcgtaatca agtactgaaa gacgccctcc 17040
attacgttga gtattgctat gcaaactatt cgaaattaca tagccactta atacaaaaaa 17100
taagaggacc gcggtttcac tcaaaaaatg attcaactca tatttccagg acaccaatcc 17160
aatggttggt aaccaataaa tttgaaaggt gtggctgaga aaaaccgtta gtgctgcaat 17220
cgcccttaga taatcaaggc ttttaatcat aataactaag catacaatta caacaattaa 17280
tcatttaagc ttatgctcac gtaaccactc cactaccctt ggagcaatca aatcacgttt 17340
ttttgtgaca acatcaagta tgttacagct ctcatcacga gatatagatg aattttcaat 17400
aacaatattg cactttctca acaattcatt tttaaaacct atttgtctga catcaacaat 17460
tttttctttt attcccaact cataaaacaa ttctttaatt tgcttgtatg agtacaatcc 17520
tattactgga attttattag ctatggctac aacattggca tgaaatcgca taccaagtat 17580
caaagtacat ttgctatatt cggaaaataa tgtcccttga aaattcacat tagtatcgta 17640
actggccact ttgacatttt cacgtctaca tgcatcaggc aaccgtgata gtatgtcggc 17700
atatacttta agatcactat aaatatgtgg aaaaaaaata aactttatta atttattttt 17760
attccacatt tcagccaaag tctcggtgaa ctcggatata aatcctgagt aatcatatcc 17820
attaattcca cctggaaacc ttgtttccaa catatctcca gccagattga tgccgatggt 17880
gatctgagtg ttttcatgat cattttccgc aatgtctttt tctaacttat ccagatttac 17940
aaaaaaccca ccgtcaggca atggtaagac tttatccaac atgggattat tagaaatccg 18000
atttctgagc gtgcccattg ctccatcatt acgaacactg accaaatatt gctttgatga 18060
agttaagatt tctaagaaat tagtaaactt tgcaagactt tcatcactac atcccatacc 18120
atcatcaaca cccaatgcat tgaaaaagat ggggactttt atttttttaa aaacctcaat 18180
ctcaattgag attgaggtgc cggttggaga agaatcaacc catagctcga aaaaattacc 18240
acctcccacg actataagat cgtactgatt tgcaatagct acaaaattat cgtcaaaggc 18300
aacatttttt cggtaaacat tgcgtatttc gaattcatcc cattgaatct ctccaagcag 18360
tccttgaaac caattgcgaa aaccataatg gttggcaatg tcaccgacat ttccggagaa 18420
acttcctatc tgcaacactt tcattcttag gtcacctgat gcttcagtat ccaattactg 18480
tcttgctttt cccacaaatg tggagatcta aacctatcta cggtttccca aaactgtgct 18540
tcggtgatct ctatatattc aaggaattct gcaaagtact tttttggaaa ctcttgatca 18600
tatttatgaa ctagagcaac cccttcttct cgcgtaattt tatcgttgcg aatttcttgc 18660
gcagcatcat atgttgccct accaatgccg aatttgatca aggtagtaaa gtagtggaac 18720
atatctattc gatcatcgat actactgtac ttggagtagg ttccttcagt gcgttccgta 18780
tttgcctgga aaccagtatg ctcgactgca tagtaatagc actcttgtgg atcccatttc 18840
aggtaatagc ccaaataatg tacctcgata ccatcgcgct ctagatcttc tgcagcaggc 18900
ggaatatatg gcgcgaaatc atttaagctg tattcaccgt ctttaataat gtctccaacc 18960
ttcacaccac ctaacaccat gtcagctggg tctgaaatag agaaaaaatt cttgtccatt 19020
gtcggtttat agttttcttc tgtcttattg ccatattcag cttgattttc accatacatt 19080
accaatttga taccaaactt tttagccatc aacggcccga taatgcgttg gccaacaatg 19140
aatggttgga atgggtgcaa taaattcaga aatgccattt ttgttaaata gcggtgcaac 19200
ttgccatttg gggtaaaaag aatattgtct aatccacctt tatggatcca gttttcaaaa 19260
ttcttccaac caatctcagt gtacttatgc ggcgcccacg tcactgttaa aggattcata 19320
ccatatttat atttaaggat atgtgaggta tatgcactgt ctttaccacc actgccgggc 19380
acgacaatgt catatccacc atcgctacgg cgatgttgat ccaacaatct aaccaaagcg 19440
tcctcgcggg cctgccagtc tatttgagca tccttggttt ctgcatagcg gcaagcatca 19500
caaataccat cagcgccaaa tcctatggtc gcttttttgt ccttgttggt atgcttgaat 19560
tcaactgtag aactgggtct ttggttggaa atcacgcatt tcttgcaaaa cactacatct 19620
tccggcaaac caaaatatgc attaaccaca acttcctcca cacttctttt caattaactg 19680
ttttgtacaa agttattaag aacctgtaac ccgctgggcc cacttttttc tgggtgaaat 19740
tgcatacccc agatattgtc tttctgcact gatgcaacaa aagtacatcc agaatacgtc 19800
gcgctgcctg tgatgtatcg atcaggtaca ttttgagcgg cataactgtg cagaaaatag 19860
aacttacgct gctcgtctgg cagtccatca aacatgccgc cattattttc atgaacggaa 19920
ttgagatcaa ctttcgccca ggatatatgc ggtaacctca ctcgtgattg ctctacgggt 19980
acaattctgg agactacgcc aggcacaagt ccaagaccag tggtaacgcc aaactcctca 20040
cccctgtcga aaagcaattg catgcccaaa caaatcccca agacatgttt tccacttttt 20100
atatattcga gcaagctagc ttgtaatcca tctttaccca atgcagacat gccttgagca 20160
aacgcaccaa cccctggcac tattaacgcg tgagaatctt taagtgcctc tggcgtattt 20220
gagattacag gatgagcacc tacgtacttg atcgcattac tcacactacg cacattgcct 20280
agcccataat caagaataca tattttcttc atttatttag taccattgat gaatgtcaga 20340
cgctgtttga attcatctat cgtattgatt ttgtaatgca atactgacgc cagacaaact 20400
ccacttggct ggatttcttt taactcttgc acatgatcag gattaccgca gccaccacta 20460
accatgactg gaatgttcac tatcgtgtta actgcaccaa gcaatggaag gtcaaatcct 20520
ttttttgtac catcttggtc tatagacgtt agcaaaatct cgcctgcacc aagatcttcc 20580
agctccttgc tccaagcaac aacatttttg cccgtaggct ccctcccggc ttccatataa 20640
gcttcccagt cattgcctat ccgtttggct tgaatagagg caaccacaca ttgactgcca 20700
tagcgcttgg caatctctgt gatgaatttc gggttaagta ttgcagctgt attcactgcc 20760
actttgtctg ctccggcact cagagccatc tcgacatctg ctaaggaacg cagccccccc 20820
cctacagtga taggaacaaa aacttcttcc gaagccttgg cgattacaga cagcaggtta 20880
ttacggttat acaagctcgc taccgcatct ataaacacaa tctcatcaat gccttgtgca 20940
taatagtttt tcgccatctc gattggatcg ccaactttcc gcaagccctc taggtgtatg 21000
cctttaatca catgttcatt tttgacatct agccttgcga tcaacctcac actgcactcc 21060
tatcgataaa gtgcttttgt atgcccttat cccaaaaagc attattcaac agaatctgat 21120
gaaactcacc tgcactatta ccattaccaa agtcagaaac tgccacgcga ggaatgtctg 21180
caacttgttg aacagcatgt ctaagggaat ccacatgtgc agtagtatta agaatcgact 21240
ctgctgttgc tctattgtgt tgcctgctac caacattgat ggctggcacg ccgaaatgag 21300
gagcctctct tactccagcg ctagagttac ccatgatgaa cgctgcattt ttttagcagc 21360
gttaaaaaat attcaaatct aatggatgga taaactctaa cgtggctcaa gtttttcaat 21420
cgcaaatact cattcaaaat aatgtctgaa ccatgatcat tattgggata tacaacaatg 21480
aatggtagag agctttctga aatataatct acgatggctt tggcttgtct tggcaaatca 21540
tctaactcag aggtaacggg gtgatacatc aaaatgccgt aatgttcgaa cgagaagcca 21600
taacgttccc tcacatcatc aatgcttggc agcgatgttg aattcataac atcaatatct 21660
ggggagccaa taacaaaaat ggattcttca ctttctccaa gctgaataag tcgatttttt 21720
gcctgttcgt tggaaacaaa atgcccatgg gacagcttgg tcaccgcatg tctaatcaac 21780
tcgtcaacag tgccagagac ctctccgccc tcaatatgtg ccactcgaat gttatttaat 21840
gcgccaacag cggctccggc caacgcttca actctatccc catgaatcac aatcagttct 21900
ggtgaaattt cttttacata atctgataaa ccagtaattg ttttggccag aatatgatcc 21960
atgctatcgc tttgattttg attgataaag cgaaataggt ttttaaatcc ggctttttct 22020
acttcttcac atgtataacc atatttcgac aacatatgca tgccagtaat gaacacatgg 22080
acgtcaaatc ccatgtcatt ttgtaatgct cgcatgaggg atttcagttt tccaaaatct 22140
gctcttgttc cagtaagaaa aacaactcgc ctactcatgc ctcaatatcc tgccgattaa 22200
ctcttttgcc actcagtata gtttgcgatg ctttacgacc aagtagctga tcatagtcag 22260
aagcattaaa atcaccgcca cctggcctac gtaaccaaat attatcttca cttaagacat 22320
caccaacatt gatatcctta attgcaacga cagatgcaaa agcaaaagct atagtttttt 22380
cttcttctaa aagtggacct ttatgtgcac cttttgctga aaaaataact tttgaaccag 22440
tgattaaatc ttgcaatgct gcagggtcca ttgaacaaac aatgtctggt cccggccgtg 22500
acatggagtc agtaaaatgc cgctcaagaa ttgaggctcc tagtgcaaca gcccctaggc 22560
aagcgtaatt cccaagggtg tgatctgaaa gtcccacaac cgcatcagga tatgcatttt 22620
taatgacttg gatagcatca agtcttacaa gctcaggagg ggtagggtaa atattcgtgc 22680
agtgcagaag agcaaaagga acttttgctt gccttaatat attgacggtt ggtgcaatgc 22740
tttcaatgct attcataccg gtactaacaa taataggttt cccaaatgaa gcaatatgcc 22800
gcacgagagg ataattattg cactcgccag atccaatttt ataagccggt atatcaaatt 22860
ttctcagtcg atttgctgcc attctcgaga atggcgtact aataaaaata ctgccttgct 22920
gctgcacata ttgcatgagc ttatattcat catcctctga caatgagcaa cgttgcataa 22980
tctcatagat tgaaacatcc gcatttccag gaataacact cttggcttca tcagacattt 23040
catcttcaac cacatgtgtc tgatgtttta ttatctctgc cccagcatca attgcagctt 23100
ttgccatatc aatcgcaaga tctaatgaac cctcgtgatt gatgccaatt tctgcaataa 23160
ctataggctc atgtccgtcc ccaattttcc gcccagaaat ttcaaaagat gccatatttt 23220
ttccttaata atgcttctgt ttctaaaaaa tcttcttcgg tgtcaatatc aacactttct 23280
tcagcagaca taatataagc aacactacca ttggagggga aaccgcctct agcctcaaat 23340
tcaaatttcg aaaagatata aatagcacca tttggcgcgt aacataatgg caaatcttga 23400
cgacgataat tagataattt ttcatcaaat aatgaaatca atttatcatt atcatctaga 23460
cgaaatgact tatatggcga cttatccaag acttccacac tgaccaaaga agtaaggcca 23520
ttattattca aagccgtcaa agcatcatca atatgatgtt catctcttaa tggggaggtt 23580
ggctgtaagt aaacgattaa atctccatcc tctatatttt caatactaat aaaatgcttg 23640
acaacatcaa cagctgacgc atcatctgtt gcgtattctt gcggccttaa tattgaactg 23700
cagccttgtg cttttgaata ctccaatatt tctttacaat cagaagatac ataaacagca 23760
tcgacatttt tagctttttt agcagcgtta attgtgtaag ctattaatgg agaacctgcg 23820
atatttttca ggtttttttt tggcactcct ttagaacctg ctctggcagg aatcaaagca 23880
aacacttttt ttttcaaaat tgaacattaa attttaaaaa ttatcgaggt tatataaatt 23940
atctaaacgc tatttttgag gataatatca attcgatatc agaaataaat taataaactc 24000
agatttattt tgttaaaaat tccgaatatg tcttttccaa tccatcatca agctcaatgg 24060
aataagtcca ccccaaactg ttgagcttgc ttacatccat aagcttacgc atcgtgccat 24120
caggttttga actatcgaac tcaattgctc cttggtaacc aaccaccttt tttaccaatt 24180
cggccaattc ctgtattgaa atatcgactc caataccgat attgactagt ggtggatcaa 24240
acacaccagt agcactctca tcacttccca gcagagaatt gaatttctcc tcaggcagat 24300
tcagcaagaa tatacaggca tctgccatat cctcactgta aagaaattcg cgcctgggtg 24360
ttccagtacc ccagaccgat acagctgcat gcccagcttg tttagcctcg tggaatttgc 24420
gtatcaatgc agggataacg tgactattct gcaagtgata gttatcgcca ggcccataaa 24480
gatttgtcgg cattgctgca agaaatcgag tgccatactg ccggttataa ctccagcaca 24540
tttcgactcc agcaatcttt gccagcgcgt atgcacgatt ggtagcttca agcgatccgg 24600
ttagaaagtg gtgctcatgc atgggctgag gagcatgctt ggggtatatg cagctggacc 24660
ctaaaaacaa taggcgcttt actccatgct tccaggcact atggatcaca ctgttctgaa 24720
ttgcgagatt gtcacggata aaatctgccg ggtaagtgtt attggccact atgccaccca 24780
ctttggctgc cgccaggaaa acatattcgg ctgatactga gcaaagaatg cttccgtggc 24840
attagcatct gtgaggtcaa gctctgcatg ggtacgcttg ataagattgc tatagccctt 24900
gccctctagc cccctaacga tagcggaacc cactaggcct cgatgccctg ccacatagat 24960
acgtgcgtgt ttgtccatag gctcaggtta ctcgttatag tcataggcag caaaaccatg 25020
ctgcttaacc agttcgtcac gctctgcgct cttgagatct tcacgcacca tttcagaaac 25080
caactcctgg aaactgatgc tgggcgacca gccaagtttt tgctttgcct tgctcgggtc 25140
accaagcaat gtttcaactt cggtaggcct aaaatagcgc gggtcaacct gtacaatgca 25200
cctgccttga ccgtcgtatc ccatctcttc ttggccctga cctttccagg tgatggcaat 25260
atccagctcg tgggcggctg cattgacgaa atcgcgcaca ctgtattgca cacctgtcgc 25320
aatgacgaaa tcctctgcct gttcctgttg caacatcagc cattgcattt caacataatc 25380
cttggcgtga ccccaatcac gcaacgcgtc cagatttccc aaataaaggc aatcttgcaa 25440
gcccagcttg atgcgcgcca aggcacgggt aattttacgg gtaacaaagg tctccccacg 25500
caaggggctc tcgtgattga ataaaatacc attacaggcg tagatgccat aagcttcgcg 25560
gtaattgaca gtaatccaat atgcataaag cttcgcaacc gcatacgggc tgcgtggata 25620
aaatggggtg ctttctttct gcggtgtttc ctgcaccaaa ccataaagct ctgaggtcga 25680
ggcttggtaa aagcgggttt tcttttccag ccccaagatg cggatagctt ccagaatacg 25740
caaagtccca agaccatccg cgttagccgt atattcagga ctttcaaaac tgactgccac 25800
gtggctcatt gccgcgaggt tatagatttc gtcgggctga acctgctgaa tgatacgtat 25860
aaggttggtg gaatctgtca aatccccata atgaaggatg aaattctggt tatcgacgtg 25920
agggtcctga tacagatgat caatgcgatc tgtattgaaa agtgatgctc ggcgcttaat 25980
gccatgtact acatagcctt tgccaagtaa aaattcagct agatatgctc cgtcttgtcc 26040
agtgatacct gtaattagag ctactttttt taacat 26076
<210> 181
<211> 4093
<212> DNA
<213> 糖原甲基菌
<400> 181
gtgaataacg gatttgtaac taacttcaag caatccagaa ccctgtgtgt cggtgctgtg 60
attgtgctcg ctttcgcatt gtcgggctgt ggcgacaagc atgaatccaa agccagccag 120
tctctggtta aggtcaatgg caaggaaatc accgtacatc agctgaatca ggagctgggt 180
cgtgccaaca ttcaggagaa tcagcgcgag caggcaacgc agcagattct gactgcattg 240
atagatcgcc agttacttga agaagctgcg ctcaaggcca aggtggatag ggatccaaat 300
gtgatgacca cgattgaacg tgcgaaatca caaatcattg ctcaggcata tctgcaatcc 360
aagttaggca gtgtcgccaa gccaagcaaa acagaaattg agaattttta taacgagaat 420
cctcaattct tcagcaagcg cagaatggtg gaaatggatc aattgttgat tgatactaaa 480
ttcgccaatg atgaattgaa aacagcactt ggcaaactca agaccttgca ggaagtagcc 540
gcatggatgg atgcccataa tattcagtac gatcaaggtc aggtttcacg cagtgttgct 600
gaattgccgc cacagatttc cgagcgcctc aaggccgagg ataagggtaa gttgttcgtg 660
atcggcatgg gccctcgcac catgttgatc atgatgaacg agatcaagga cagcccagtt 720
tcacttgcag aagcaacacc gcaaattgaa aacaatttgc tgaataaggc gcgcaaggaa 780
gttgctgaaa atgaagtcaa gcgcttgaaa gccgatgcca agattgagta catcgataaa 840
aagatggaaa cagcgactga aaccaaggca gccaaaaaga agccaagctc tactgaggat 900
gatatcgcca gtggtgttag tggcttgaaa taagtactcc ccatccttaa tatcaggacg 960
atagtaaaat gaaaaaatta atgacatggt ttttcttgct gatgctgagt ctgacgcctt 1020
ttgtaacgca tgctgcagaa ggtgacattc ttctcggcgc tggcgatgtg ctgaaaatat 1080
cggtgttcga gcagcctgat ctgtcacttg aggtcagagt gagtgaatca ggttccatta 1140
cttatcccct gataggtgaa gtgcgtgtgg gtggtggtac ggttgccgcc gccgagcaaa 1200
gaattgccac catgctggaa aagggtggtt tccttaagag tgctcacgtc aacatcatcg 1260
ttgcgcaatt gcagagcctt caagtctcta ttctgggtca agtcaatcgc ccgggcagat 1320
accctataga tagcgctaaa acgctggcgg atgtgcttgc cttggctggt ggtgtatcac 1380
ctgaaggtgg cgatctgatc acgctggtgc ataacgtcga tggtaaagcg gtcagggatc 1440
agattgacct tgctgacatg atgcgtactg gcgatctcag caagaacatc cgcgtagctg 1500
gtggtgacat catttatgtt gaacgtttcg ataaattcta tatctatggt caggttcaac 1560
gtgccagcca ttaccgtctc gaacatgaaa tgacagtatt gcaagcgctt tctgtaggtg 1620
gtggcttaag ccctcgcggc acagaaaaag gcgtcaagat caagcgtcgt gatgctagcg 1680
gccatattga agtaatcact gccaaacatg atgacctcat caagcccaac gatgtgatct 1740
atgtgcagga aagtttcttt taatagattg cagattttaa taaatacttg ataggcaagg 1800
ttaatctaat gagcttttct caacttttac tgatattcaa agcgcgatat aagatattgt 1860
taagcaccat tgttgtggcc ctggtcgtag caattgcgct caatattttc ttgccaaaca 1920
gctataaggc aaccaccagt atcctagtca actataaagg tgtagatcct gtgactggta 1980
tggctgtccc tgcccagctg cttccaggtt atatgggtac ccaggtggat atcataacta 2040
gcaagaaaat tgctaagagg gttgtgacca cattaaagct caatgaaagt agtgaggttg 2100
tggagagttt caatgactcc acaggtggtg aaggtgatat cgttgattgg ttggcggatt 2160
tgctgatctc acgtatcgaa gttcaacctg cgcgcaacag tagtgtgttg cagctggagt 2220
ttgatggagc caaccccaaa tttgctgctg ttgttgctaa ctcctttgcc gaggaatata 2280
tcaaggccac tatcgaactc aaggttgagc cttcgaaaaa ggcggctgaa ttttataccg 2340
ggcaattgaa ggatttgcgt gccgatatta cccgggcgca gcaaaagctt tccgattacc 2400
aacaagataa aagcatcgtc agcgttgatg agcgtctaga cattgaacgt gccaagctga 2460
atgaactttc ctcgcagtta gtgatgtcac aagggcaaac tcttgaggca cagtctcgtc 2520
agactggtgc acaaggtagc aatgcttatg gatctccgga tgtcgcgagt aatccaatgg 2580
ttctgcacct gaaaacagag attgctaggt ctgaatcacg cttcgcggat atctcacaaa 2640
aatatgagag aaatcaccca ctctatcagg gggccaaagc tgagcttgac aatctgaagt 2700
ctgaattaag taagcaaatc caggcggcta ccgtcaatat atcgagcaat tatagaatcc 2760
ttaagcaacg cgagagtgaa atccgcaatg ccttggctga gcaaaaaacc aaggtcatgc 2820
tgttgaacaa ggatagggat gcactgacgg tattgacgcg tgaagtcgag ggtgcgcaac 2880
gcgcttacga actcgcgact cagcgatata ctcaaataaa tcttgaggga cagtctaatc 2940
aagctgatgt atccatcctt aatccagcga caccaccact taagccatca agcccgaaaa 3000
aaatattgaa cgtggcagtt gcgttggtgc tgggtacaat ttttggcttg ttgtttagtt 3060
tgttggctga gctcactaat gagcgaattc gctcagaaag agtgctggta gagattgttg 3120
gcgcaccgct gctgggtgtg atcgacaaaa ataaaaccca ttccagaatt cagcgcctgc 3180
tggctaaaaa accctaattt gtgtggatat agacatgact aatgatgttt ccaatactag 3240
ttccattccg gcattgaatg ctgatttcaa tatcggtgga atgttgctca agatgggtaa 3300
gattacaccg caggatgcgg agcgtatcct gcgtgtgcag aaggaaagag gcgttcgctt 3360
tggtgaggct gccgagagtt tgggcctagt ttcctctgcc gatatcaact atgtattatc 3420
caagcagttt gcctatccct acctgatgga tggtcgcggc gatttctccg agaacttggt 3480
cgcggcttat gatccattca gtatcaatgt ggagaagtat cgcgccattc gtagccagct 3540
catgctctac tggtttgcac aagggaaaaa gagcctgtca ttttccagtg tttacgacaa 3600
ggacgacacc agtgacttgg ttgccaatct tggcgtggtt ttctctcaac tgggagagaa 3660
aacactcatc attgatgccc atcttgatag cccacggcag aatcgcattt ttaatatcaa 3720
gagcactgcg ggtttgtcgg atattctggc aggccgggtt acggattact cctcttccat 3780
cactaggcta gtcgagttcg agcatctctc catcttgtct tctggcacca ttccacctaa 3840
tccgcgagag cttctgggac gtggtttcct caagcagttc atcacggcaa ttgctaatga 3900
ctacgatgtt atcctggtcg atgcaccttc ctttgtccgc cactctgaac cgttgtctgt 3960
ggcaagtgct acggaagggg tggtgcttct tgccaagcgt catgtctcca aagccaatga 4020
cttgagcaaa gtggttgatc agctttccaa gatcagggtg cctgttgttg gcacggtatt 4080
gactgaaaac taa 4093
<210> 182
<211> 2434
<212> DNA
<213> 糖原甲基菌
<400> 182
atgcttacgg atgaataccg atacaagatt ctgaaattgg tgcaggaaaa accagatatc 60
agccaaagag aactggcgaa agcactaggc attagcttgg ggaaaaccaa tttttgtctc 120
aaagccttag cgcaagttgg cttgctcaaa gtatctaatt ttcgcaacag caagaataag 180
ttggcatata tgtatgtcct cacgccgaca ggcatagaac ataaagctgc tgtgacactc 240
aactttctca aactcaagct caaagagtac gaacaattag caggagagat tgaagagtta 300
cgtagtgaga tcaacgctaa ggtaaatgat taagggcgga gacagttcct taggaaaaac 360
atatgttaaa aaaagtagct ctaattacag gtatcactgg acaagacgga gcatatctag 420
ctgaattttt acttggcaaa ggctatgtag tacatggcat taagcgccga gcatcacttt 480
tcaatacaga tcgcattgat catctgtatc aggaccctca cgtcgataac cagaatttca 540
tccttcatta tggggatttg acagattcca ccaaccttat acgtatcatt cagcaggttc 600
agcccgacga aatctataac ctcgcggcaa tgagccacgt ggcagtcagt tttgaaagtc 660
ctgaatatac ggctaacgcg gatggtcttg ggactttgcg tattctggaa gctatccgca 720
tcttggggct ggaaaagaaa acccgctttt accaagcctc gacctcagag ctttatggtt 780
tggtgcagga aacaccgcag aaagaaagca ccccatttta tccacgcagc ccgtatgcgg 840
ttgcgaagct ttatgcatat tggattactg tcaattaccg cgaagcttat ggcatctacg 900
cctgtaatgg tattttattc aatcacgaga gccccttgcg tggggagacc tttgttaccc 960
gtaaaattac ccgtgccttg gcgcgcatca agctgggctt gcaagattgc ctttatttgg 1020
gaaatctgga cgcgttgcgt gattggggtc acgccaagga ttatgttgaa atgcaatggc 1080
tgatgttgca acaggaacag gcagaggatt tcgtcattgc gacaggtgtg caatacagtg 1140
tgcgcgattt cgtcaatgca gccgcccacg agctggatat tgccatcacc tggaaaggtc 1200
agggccaaga agagatggga tacgacggtc aaggcaggtg cattgtacag gttgacccgc 1260
gctattttag gcctaccgaa gttgaaacat tgcttggtga cccgagcaag gcaaagcaaa 1320
aacttggctg gtcgcccagc atcagtttcc aggagttggt ttctgaaatg gtgcgtgaag 1380
atctcaagag cgcagagcgt gacgaactgg ttaagcagca tggttttgct gcctatgact 1440
ataacgagta acctgagcct atggacaaac acgcacgtat ctatgtggca gggcatcgag 1500
gcctagtggg ttccgctatc gttagggggc tagagggcaa gggctatagc aatcttatca 1560
agcgtaccca tgcagagctt gacctcacag atgctaatgc cacggaagca ttctttgctc 1620
agtatcagcc gaatatgttt tcctggcggc agccaaagtg ggtggcatag tggccaataa 1680
cacttacccg gcagatttta tccgtgacaa tctcgcaatt cagaacagtg tgatccatag 1740
tgcctggaag catggagtaa agcgcctatt gtttttaggg tccagctgca tataccccaa 1800
gcatgctcct cagcccatgc atgagcacca ctttctaacc ggatcgcttg aagctaccaa 1860
tcgtgcatac gcgctggcaa agattgctgg agtcgaaatg tgctggagtt ataaccggca 1920
gtatggcact cgatttcttg cagcaatgcc gacaaatctt tatgggcctg gcgataacta 1980
tcacttgcag aatagtcacg ttatccctgc attgatacgc aaattccacg aggctaaaca 2040
agctgggcat gcagctgtat cggtctgggg tactggaaca cccaggcgcg aatttcttta 2100
cagtgaggat atggcagatg cctgtatatt cttgctgaat ctgcctgagg agaaattcaa 2160
ttctctgctg ggaagtgatg agagtgctac tggtgtgttt gatccaccac tagtcaatat 2220
cggtattgga gtcgatattt caatacagga attggccgaa ttggtaaaaa aggtggttgg 2280
ttaccaagga gcaattgagt tcgatagttc aaaacctgat ggcacgatgc gtaagcttat 2340
ggatgtaagc aagctcaaca gtttggggtg gacttattcc attgagcttg atgatggatt 2400
ggaaaagaca tattcggaat ttttaacaaa ataa 2434
<210> 183
<211> 4120
<212> DNA
<213> 鞭毛甲基菌
<400> 183
ttgaatactg aatatggaag cacaataatg caatggtcga aaatgacgaa aggggcgttg 60
gtcgccttga tgattagtat cgggctgtcg ggctgtggag ataaatctaa tgaaacaaag 120
gctagccaat cgctggcgag agtgaacggc aaggaaataa ccgtccatca actcaatgaa 180
gagcttgctc gggccaatgt ccagccagcg cagaaagaag ctgctaccaa gcagatattg 240
caatcattga ttgaccgtca actgttggag caggctgcct tgaaagcaaa agtagaccgg 300
gacccgaacg tcatgcaagc cattgagcgc gcaaaatccc aaatgattgc ccaggcatac 360
ctccagtcta gggtggctaa cataggcaag ccggacaaaa cagaagttga gaatttctat 420
aagcaaaacc ctcaactatt ttccgagcgc aagctggtgg aaatggaaca aatattgatt 480
gattcacgtt atgtcaatga cgaattcaag tctgcgctcg gtagcttcaa aaccctgcag 540
gaagtcgctg cgtggttgga tgctaaggga atccaatatg accgtggaga agttgcccgc 600
agtgtggcag agctgcctcc acagatttct gagcgcctga aggatgcaag gcgtggccag 660
ctgtttgtga tcggcatggg accgaggacg atgctggtgc tcatggatag cgtaaaggag 720
agcccggtat cactggcaga tgcgacaccg caaattgagc aaatgctctt gaataaaaag 780
cgtaaggaag cgggtgaggc tgaaatcaag cgactacggg ctgaagcaaa aattgaatat 840
ttagacaaat cggccgaagt accacaacaa ccagaaaaag ccgaacagtc aaaaccctct 900
agtgtcgatg atgatattgc tcgcggagta agcggactaa agtagtaatt ctataaaacg 960
tgtataggtg tagtgccatg actaaattga tcaaatggtt tgtaacggta gtcctgacga 1020
ttgttgtatt caatgttaac gcagcggatt cggatattgt tcttgggccg ggggatgttc 1080
taaggatatc tgtatttgaa cagcctgatc tttccttgga agtaagagtg agtgagtctg 1140
gcactatcac ctacccgttg ataggcgaag tcagagtcgg tggagaaaca cctgcagctg 1200
ctgaacgcaa aattgccagc atgctggaaa gcggtggatt cttgaaaaac cctcacgtga 1260
atatcattgt tgctcagttg cagagtcagc aggtttctgt gctaggtcag gttaacaggc 1320
caggtcgcta cccactggat agtgcaaaat ctcttgcaga cgtactggcg ttggccggtg 1380
gagttgcacc tgatggggga gatttgatta gcttggttcg caagattgag gggaaaagtg 1440
ttagagagat aattgatttt gctgaaatga tgcgggatgg cgacttaaat aaaaatatct 1500
tacttacggc aggagatatt atttatgtag atcgagctcc tagattctat atatatggtg 1560
aggttcagcg gccaggacaa tatcgtcttg agtatcatat gacagtgctg caagcactcg 1620
ctgttggtgg tggccttagt ctcaggggaa cggaaaaagg tattaaggtg aaacggttag 1680
atgatgaagg tggtgttaag ataattaaag taaagcatga tgattttatt cagcctaatg 1740
atgttgtata tgtacaagag agtgtatttt agtttgtttt ttgaataaca gctgaataat 1800
caaaaaggta atctaagatg agttttatca gatttatttc tatcattaaa gctagatata 1860
aaattattat ttttacttta tttataacgg tattaactac cgctattgtt acaatattgt 1920
tgccaaaaaa ttataaagca acagcttcag tgcttgttaa ttataaaggc gctgatcctg 1980
taacaggtgt aatgcttcct gcgcagttaa tgccaggtta tatggcaacg caagtggata 2040
ttatttcaag taaaaacgtt gcaaaaaagg taattgataa actaggtctg gcagatgttc 2100
cagccgtaaa agaggacttt tatcaagcaa cttcaggtaa aggtgaaatt aaagaatggc 2160
ttgcagattt attgctaaaa aaacttcaag ttaaaccatc tcgagagagt agtattattg 2220
atattagctt ttttggggta aatccccagt ttgcagctac aatcgcaaac gaatttgctg 2280
agtcttatat gcaaacttca atacaactta aagttgagcc ttctcaaaaa gctgctttgt 2340
atttcgttga gcaattgaaa gaactgagag aagatctagc tcaagcgcaa tcgaagcttt 2400
cagagtatca gcaagagaaa gggattgtaa gtgttgatga aagattggat gtggaaagag 2460
ccagattaaa tgagctttca tctcaattgg ttattgcaca agcacaagtt atggaagcga 2520
gatctcggga aaaaaattca agtggaaaag aagcttatga gtctcctgat gtagcagcta 2580
atccaattat ccaaaatctt aaaactgaaa ttgctagagc agaatcaagg tttgcagatg 2640
tttcgcagaa atttgaaaga aaccatcctt tttatctagg agctaaagca gaaattgaaa 2700
atcttaagtc tgagctagat agacagatca aatcggtttc aagtaatgtg gcaagtaatt 2760
caagaattct gcaacaacgt gaagcggaaa tacgtttggc tttaaataat caaaaagaaa 2820
aagtattaca acttaatcga gatagggata ttttatctgt tttgacaaga gaggttgaaa 2880
atgctcaaaa agcatacgac atggctatgc aaaggtatac tcaaacgaat attgaaggtc 2940
agtcaaatca atctgatatt tctttattga atcctgccgt ggcacctctt actcccacta 3000
gcccaaattt attgctgaat attatattgt caatcctctt gggtatgttt ttaggaatag 3060
ggtttggagt tttagctgag tttgttgatc gaagagtacg gactgctgat gacttaattg 3120
aagtattaca agccccactt cttgggacta ttagtaaaga aaaaagaaaa ctgagatttt 3180
ttaaaaatac ttcaaacctg ataactttag ggaaggctga attatgattt catttacacc 3240
ttctaattca aactctgaaa aagtagaaaa tgcaccattg gtaaacgaat tttcagaatt 3300
tacaattggt agtttattat tgcggatggg gaaaattaca cccgaagatg ctgaaagaat 3360
tatgcggtta cataaagaga agggtttgcg ctttggagaa gctgctcaag cattagggtt 3420
gataactgaa gatgatattc aacaggtttt atcgaggcaa tttaactatc cttatttatc 3480
acctgaccaa aactcatatc ttaatgagct cgttgctgca tatcagcctt ttagtaacaa 3540
agctgaggtt ttgagagcag tacgcagtca attaatgctg cattggtttt caccggaacg 3600
aaaagcacta gctgtttctt cagtaagcag cagcgataat gcaagctctt ttgttgcaaa 3660
tcttgcagtt gtttttgcgc aattgggtga aaatacatta ttgattgacg ctaatttacg 3720
ctacccacgc cagcatgaga tatacaatct gagtaacaaa cgtgggttat ctgatatctt 3780
agcaggaaga gcggggtatg atgtaatttc aaaaataaat ttttttgaaa acttatctgt 3840
attaactgcc ggtacattac ctcctaatcc tcaagagctt gttagcaagc caacattcgg 3900
aaatttaatt aaagagttgg cttgtgttta tgatgtaatt ttattggata ctcccgaact 3960
tagtaattat tcagatggtt atgcaattgc ttttactgtt ggaggaattg tattagttgc 4020
aagacaaaat catactcgag tgaatgattt atctattgct gtagaacaat gcaagaataa 4080
tggtactaag gtaattgggt caatattggt tgatttgtag 4120
<210> 184
<211> 13447
<212> DNA
<213> 鞭毛甲基菌
<400> 184
atgctgcttc ctgtcattat gtctggcggg gccggttcca gattatggcc ggtttctcgt 60
gaaactctaa ctaagccatt tatcgaatta cctgatggca gaacccttct gcagaagact 120
ttgcaacgta ctgcttgcct ggatggtgtg agcgaagtgc tcacagtaac gaataaggaa 180
tattacttcc tgacacgtga tgtctatgag gcaacagaca ctaatgtttc ccatagctac 240
ttactagaga cgatagggcg caatactgct cctgccattg cagttgctgc actacatgcc 300
gctgcgaaac atggggaaga tgtagtgctg ttggtgatgc cggcagatca tcttattggt 360
aatcaaaaag ttttttcaaa agcagtgact gttgcgacag atatggcggt gaatggctgg 420
atagtcacgt ttggtgtaga gccaagcacg cctgaaacag gttatggcta cattgaaggc 480
ggagagtcaa ttggggactc aggcgcgcgt agagtcgttc gatttgtcga aaagccagat 540
ttggaaactg ctgagaaata tattgcttta ggtcgattta catggaatgc aggtatattc 600
tgttttactg caaaaaccat tattgctgca cttgcggagt atgttccaga agtgcttgag 660
atagcaaaaa agaccctggc atctagtgac tccaaaactg agcctgttgt attgggcgag 720
gagcactttg catcaagtcc agatatttcc atagattatg ccgtcatgga gcgtgcttca 780
aaagtggcgg tagtcgcagc tgattttgac tggagcgaca ttggttcatg gagcgccatg 840
gctgagttgg tccagtcaga tgagcgtggg aatagggtga atggcgaagc tttattggtg 900
gatgctaata attgctatat ccaaagtgat tcccgtcttg tggctggtat aggtattgat 960
aacctgctgg tggtcgatac acccgatgcc ctgcttgtgg ctcatcactc cagagctcag 1020
gatgtcaaaa ccgttgtgaa gcaactcaag cttgagtccc atagtgcggc aaattaccat 1080
cgcaaggtac accgtccatg gggcacatac accgtattgg aagaaggcgc taattttaag 1140
atcaaatgca tcaaggtaaa gcctggtgcc agcctgagct tgcaaatgca ccatcatcgt 1200
agtgagcatt gggttgtagt aagcggtata gctaaagttg tcaacggcga gcgcgagctg 1260
ctcattaatg ccaatgagtc tacttacatt ccagcaggac acaaacaccg tcttgaaaat 1320
ccaggtttgc ttgacctggt gattattgaa gttcaatccg gggaatattt gggcgaagac 1380
gatattgttc gttttcaaga tatctacgga cgcacttgat gatcagcatg ttaaaagcct 1440
tatggcttta tcgcggcttt gtgttgggca gcgtcaagcg cgagtttcaa tccaagtacc 1500
gtaattcgct gctaggcgca gtctggacgg tcttgaaccc cctcgcaatg atcgtagtgt 1560
acacagtgat tttctcgcag gtaatgaagg ctcgtttgcc tggcgtggac agtacttttg 1620
cgtttagcat tcatttatgc gctggcatac tcacctgggg cttgtttgct gagattgtcg 1680
ggcgctcaca gaccacgttc atcgataatg ccaacttgct caagaaactg agtttccccc 1740
gtctatgtct gccagtcatc gtcaccgcca ccgcgctagt taactttgcc attgtttttg 1800
ggttgttcac agcgttcttg ctgctgatcg gtatgttttc gggttggcct tatttggtgc 1860
tgatcccggt attgatactg atgatcgtct ttgctctagg cttgggtatt atattgggcg 1920
ttctcaatgt gtttttccgc gatgtaggtc agttctttgg cattgtgctt agtttctggt 1980
tttggcttac gccgattgtc tatccggtca gcattcttcc agaacgggta caagattata 2040
tgcggcttaa ccccatggcg cgcttgatgg aggctttcca aggaatattg gtacaagcaa 2100
aatggccgga ctggtacagt ctatggccag tgtttgcgct gtctatcgtg ttgtgcctgc 2160
tggggctgtc tttattccgc aaacatgcgg gcgatatggt ggatgaactt taatgggtac 2220
tattgttgtc accaacctgg gtaaggccta caagcaatac cccagtcgct ggtctcggtt 2280
gttggagtgg atagatctga ggcgtaagcc gcaccaccaa ttgaagtgga ttctgcaagg 2340
agtaagtttt catatccagc caggagagac ggaggcagct ttgccgtgac tgctgccaag 2400
cgttctaata cgagtattaa gcctaacctt gcagtgatca attggatgct tgagcaagaa 2460
gaccggatgg gattatctac cccaaggcct tatcgtgaat ttgaggagcg tgtatatcgt 2520
catcgcgatg atctcaggcg cttaattcat tcgttagtag ctgacggcaa aaaaatatat 2580
gggtatggag cttctgccaa aggtaatgta gtactacaat tttgtggctt tacttctgag 2640
gaaatccctg ccattgcaga agtaaacgaa gaaaaattcg gacgagtcac tccgggaacg 2700
catattccca ttatttcgga aaaagaggcg cgcgctgcca agcccgacta cttcttggtg 2760
cttccatggc atttcaaaga tggtatcctg cgccgtgaaa aggactttct agctgatggc 2820
ggcaggttta tcttcccatt tcctgagatc gaaatcgtct agtttccaaa aaaagatgaa 2880
ggaaaataat aagataattt agacgctgtt ctaacgaatc cattatttac ataccatata 2940
tacatataca gtaagacttt aaatacataa ggcataatac gatgaccata aaaactgcca 3000
tcattaccgg catcacaggc caagatggtg catatctcgc agaacttctc cttagtaaag 3060
gctataaggt ttacggtacc ttccgccgta caagctcggt caacttctgg cgtattgaag 3120
agctgggaat tgaaaatgac ccaaatcttc ttttggttga atacgacctg accgatttgt 3180
cagcaagcat ccgtctattg cagagcacag gtgcaacaga agtgtacaac ttagctgcgc 3240
aaagttttgt gggcgtgtct tttgagcaac ctattactac cgcggagatc acaggtgtcg 3300
gtgcgctcaa tcttttggag gccattcgtt tagtaaatcc caatattcgc tattaccaag 3360
catccacatc cgaaatgttc ggcaaggtgc aggcgattcc acaaacggaa gatacgcctt 3420
tctatccacg cagtccttat ggtgtcgcca agctgtatgc gcactggatg actgttaact 3480
atcgtgaaag ctatggaatc ttcggatcta gcggtatttt attcaatcat gagagtccgt 3540
tgcgtggtcg cgagttcgtg acgcgcaaga tcacggattc ggtggccaag atcaagctgg 3600
ggaaacttga ttgcctggag ttgggtaact tggatgcaaa gcgtgattgg ggctatgcca 3660
aggattatgt ggaaggcatg tggcgcatcc tgcaggcgga tgagccggat acctttgtac 3720
tggcgaccaa tcgtaccgag actgtgcgcg attttgtaag catggcgttc aagggggctg 3780
gcattgctgt tgagttcaag ggcaagggcg aggacgaagt tgccgtggat actgcaaccg 3840
gtaagatagt ggttcgggtc aatccgaagt tttaccgtcc agcggaagtg gacctactga 3900
tcggtagccc agccaaggcc aaggccaagc tgggttggga accgaagaca acgctggagc 3960
aactctgcca gatgatggtc gaggccgatc tgcgccgcaa cacggaaggt ttctcatttt 4020
gagaattctg cttactggtg ctgatggatt caccgggcgc cattttctga cggccgcgaa 4080
agcggccggc catgaggttg ttgcactgag ggccgatttg acggacaagg ctgtattgca 4140
acgcgaagtt gaggcggctc gtccggaagc agtggttcat ctggcagcga tcagttttgt 4200
tggtcatgcg gatgttagtg ccttttatga cgtcaatgtg atcggtaccc tgaacctgtt 4260
ggatgcgctg gctggcttgt ccgtgacgcc gcgcagcgta ctgctggcaa gcagtgcgaa 4320
tgtgtatggc aatgcagcgc attcacctat caccgaagag caggcgccgg cgccggtcaa 4380
tcactatgca atgagcaagc tggccatgga gcacatggcc cgtacctatc tggacagact 4440
gccgttgttt tttgtgcggc cgttcaatta cacggggccg gggcaggctg agtctttcgt 4500
gattcccaag ctggtggcgc atttcgcgtg caaggcgcag accgtggaac tgggcaatct 4560
ggatgtggag cgcgagttca atgatgtggc tttcgtttgc gaggcctatc tgcgtttgtt 4620
ggacaaggct gtgccgggtg aggtgtttaa tatctgcagc ggtgctccgg tgacattgcg 4680
tgcagtaatc gggatgttga gggaattgac ggcgcatgat atcgaggtca aggtaaatcc 4740
gcagttcgtg cggaataacg agatcaagac attatgcggt gatccatcaa agctgttccg 4800
tactattgga gaggggaggc tggttccttt agcgcttacc ttgaagatca tgctggaaca 4860
cgctacgcga aaagaaaaaa aatgatgaag gtaggttttg gtgtcaccgt gcttacacgt 4920
tgcctggcat tggggggaat cgatggaatt ggtagttata cccgggagct gatgaaaaga 4980
ctcgaggctg acccggccgt cgagcttttc cctatctcgt acgggtattc tccgtcacag 5040
tttcctatcg gctcacgtgc tccgacgaca tttggacgat atgcgccgct tgctgcagta 5100
tcggctgtat ccgggtttcc ctttctggga acagctcaat tgaaggagcg tgttgatctg 5160
attcatgcgc ctgatcatct tattcccaac tacggaaaag ttcctgttat tgcatccatc 5220
atggacgcga ttcccttgtc gcatccggag tgggtatccc ccaagttgcg caagatgaaa 5280
aatgcgttat ggaagcgctc tgcgcactgg gcatcgcata tcattactat ctctgagtat 5340
tcgaagcagg aaatttcaca gcatttcggt attgaggcac aaaagatcag tgccatcccg 5400
cttggcgtgg atgagcggtg gtttcagccg ttggaagaag aggcgatgaa ggtggtattg 5460
agacggtaca atctgcctca atactatttt cttgtcgtgg ggacgctgca gccaaggaag 5520
aatgtcggcc gggtaatcga ggcatatcgg tccttgcccc aagggatacg taacgaagtg 5580
ccgttggtga ttgttggtag ggcagggtgg cgatgcgagg atgtggttga aatgttgact 5640
tcgtcttctt caggaaattc tctgaggtgg ctcaagcatt tgccggatgc cgacttgctt 5700
gcagtgttga aaggtgcaac ggctttggtc tttccttcgt tgtatgaggg atttggtttg 5760
cccgtagtcg aagcttttgc ggctggaact cccgttatta cttccaatac cacttctctt 5820
ccagaggtgg cgggcgatgc cgccatgctg gtgaatcctc tgaatgtcag cgacattgcc 5880
gctgcaatgc aatcgatgct ggaacagccg gaactggcag agagtttcag gaacaagggg 5940
caagaacgcg cattggcata ttcgtgggac aaaacagcct ccatgacgct tgacgtctat 6000
aaaaagacgc gagaggctgc ttaacatcaa cgcaccgtca aacatcgcac tccttccctt 6060
tttatgatca tccgttttct gggcgcacag tggctcgccg ttggttttgt cggggtcatc 6120
tctctggcgg tcagcatttt gattgcgcgg acgcttgggc cggattcatt tggtgtttat 6180
tcggttgtct tgtccggcgg agccattgcc gccattctgc ttgatggtgg tttcgggcga 6240
ttgttgcaaa gagaacgcgc ccatcccaca cctgcattgc tcagattcct gcccatattg 6300
ccgcaggctg ccttggggca tgtgattatc gcggccagca tattttcgtt gatcgcttta 6360
ttggtactgc ccaagcatgc gctgacgatt gttgcggtta tctggttttt cgcagcatct 6420
gtgaccaatc agttcggttt gaacattctc cgcggagatg ggcggatggt aagggatgcc 6480
tcgtggcaga tgggcaatcg aaccttcaca gctgcgtgcg tgtgcattgt cattctgatg 6540
ggagctgaga aaccgtggca ggtattcttt gcccagtttg tcggtgcgac cgccttcggt 6600
ttgctgatca tgcactatct gcgcacgcgc ccgctatgga agattcctcc tactctttat 6660
gcggcaacct tgccattcgt gtggttggat ctcgcgacag tcctttattt tcgagcggac 6720
atgctgttgc tggaatggtt agatgtgtcc aagtttgaag tcgggaaata cggggttgcc 6780
tgccgcttga ttgaggcggt gattctgctt gcttcgccgc tctgtattat tttgttccgc 6840
aagtttcgtc tgggtagcgc ttctccccga ctgatgttgc ggagaatgct gccggtgctg 6900
gcaggggcgc tgatggttgg agtgttcttc atggtgtttt tctggttgtg cagcacgcct 6960
ttgatcgcgg ttgcatatgg cgaggcctat gcgggagctg atcatattct ggcgatactc 7020
ggctgcgctt tgctttttat tttgccaaat ggcgtgctga accaagctgc gctagcgctg 7080
ggtatcgaac gttggctggc aatgtcggca tcttttgccg cagtgctaaa tattgcagga 7140
aatctctggc tgattcccca atatgggttg attggagctg cctggatgac tgttgtgacc 7200
gaagcggtgt taggctgctg cgttgcgtta gggctatggc gccaccgtaa taggagtgtt 7260
taatgcagga tcttgccgtt gctcatgttt atcgtaccta ttttcctgac cctccaggcg 7320
ggttgcagga ggcaattcgc cagattgccc tcacgacggg tatgcagggc gtcgataata 7380
cggtgtttac gctttctccg cagccgcgtc cggcaatctt gcagcgtccg gaggcttgtg 7440
ttgttcgttg ccgctcctgg gcggctccgg catcatgcga tctgggcggt atcggcgcat 7500
ttcttgcgtt ttccaggttg gcggaaaaat ctgatgtgct acattacctt tttccgtggc 7560
catttgcgga tgttctgcat acggtggttc gcccaggttg tccggccgtc atgacttata 7620
tctcggacgt ggtgcgtcag cagcttttag ggaggttata tgctcctttg atgtggaagg 7680
tgttgcgcca gatgaggctt gtggtggcga attctccagc gtatgcacgc accagtcccg 7740
ttctctccca tcctgagatt cgcgaaaaag tcagggttat tccacttggt attgaggagt 7800
cttcttatcc taaatcaggg gatgaggaga ttctgcagcg tctaggcatt gggaaggatg 7860
agccttattt tctttttatt ggcgttcttc gttattacaa aggcgcgcat tttctggtca 7920
aggcagcaaa gcggataggc gcaaaggtgg tgtttgctgg cgcggggccg gaaggcgcgc 7980
gcctgaaagc attggctggc gaagtcggtg cagagaatgt gatttttgcc gggatggtga 8040
ctaacgcgga aaaagtaacc ttgcttcaat gctgcagagc gcttgtgttg ccatcgcatt 8100
tgcggtctga agcgtacggc atggtgctgg tagaggctgc catgttcggg aagccgctga 8160
tttcttgcga aattggcaca ggcacttcat atgtcaacca tcatgaagaa acagggtttg 8220
tcgttgagcc ggcctctcct gaagcattgg cgtcggcgat ggcggttttg ttatcagagg 8280
ataggctggc tacagagatg ggagctgctg ctcgtcagcg gtatgagctg ctcttttccg 8340
gcccggcatt aggaaaggca tatgctgcat tgttccgcga agttgacgct tcgtagcaga 8400
gtgcgtcatg atgaagtagc cagagttgta acgtttttgg gattatcctg ttggttttct 8460
tgattgttaa tacatgatgc aattactggt gacaggcgct acagggtttg taggtaaaac 8520
tttgtgcagt gcgctaaggc ggcagagctt ccccgtaaaa gcaattgggc gtgcgggcac 8580
tatccgggct gacgctttgg gtgatcaggt tgcttcaatt gacggtcaaa cggattggtc 8640
actgatattg gacggcatca atgccgtcat ccatctggca gccagggtgc acgtcatgcg 8700
ggaacagctt gctgatccct tggcggcata tcgtgaaacg aatgtcgaag ggacgctgaa 8760
tctggcgcgt caggcggcaa aggccggagt taagcggttt gtattcatta gttccatcaa 8820
ggtcaacggc gaacagactc tacctggaaa gccttttact gcgtacgatg taccagctcc 8880
cgaagatgcg tacggtattt caaagttcga ggcagagcag ggtttgctgg ccctggcgcg 8940
ggagacaggg atggatgtgg tggttattcg ccctcctttg gtttacgggc ctggagtgaa 9000
gggtaatttt gccagtatga tgaagttggt gaaaagtgga ataccgttgc ctctgggcgc 9060
cattcataac caacggtctt tggtggcgat tgataatttg gtgaacctca tcgtcacgtg 9120
tattgaccat cccgcggcag ccaaccaggt ttttttggta agcgatggcg aggatttgtc 9180
cacttcagat ttgttgcggc gtttggccaa ggctgcgggc gtttcctccc gattgatgcc 9240
agtgtctgcc cgctggctag agatgggttt gcgtatgtgt ggcaagcgat tgatcgccca 9300
gcgtctcctg ggatcattgc aagtcgatat ttccaagacg cgcgagttgt tggggtgggt 9360
tccgccgatc tcagtggatg agggcttgaa gcgctgtttc tctaccaagg gctgattctt 9420
gatccgattt tttgacatta ttttttcggt gataggcttg gtactgggat tcccgctatt 9480
gctatcgatt tataccctcg gcttgtttga tacaggtgct cccttgtttc gccaggtgag 9540
ggttgggcgc taccggcagc cgtttacttt ggtgaaattt cggacgatga aggtggatac 9600
ggcttctgtg gcgagccatc tggcttccac caattccatc acccggctcg gacggttctt 9660
gcgcaggacc aagctggatg agctgcccca gctctggaat gtcctgaagg gagaaatgag 9720
cctggtgggg cctcgaccga acctgttcaa tcaggaggag ctgatggccg agcgcgagtt 9780
gcgtggcgtt taccatgcgc ggccagggat taccggcctt gcacaggtga atgatataga 9840
catgtcgacg ccaaggctgc ttgccgagac cgatgccagg atgctgcgcg agatgaatgt 9900
acggctttat ttcaagttgc tgattcagac ggtgctgggt cgaggacagg gcgaccgggt 9960
cgtgcgctga gctcggcagg aaccaatgcc tggctacaaa gtgttgatcc atgattggtc 10020
gtcactgtcc cgtggttttt agtagaatgt tattcatttt cactttaggc tgggcgcgtg 10080
ctgcattatt tcccctcatt caagtggtcg aactacatca gtttgaagaa tccacgctct 10140
ttgagcgctt ggatatatga cattgttgct gctgcgctgg catggtgggc agccttcctg 10200
ttacggttca attttgatat tccggccaat tttgtccaga gtatgctcga cagcgcagca 10260
tgggtgattc cgctgcaggc atttgtgttt ctgctggctg ggttgtacaa aggcgtctgg 10320
cgttttgcca gcctgccgga tttgcagcgc ttggtgcgcg cgattgcgat cagcgcagtg 10380
cttgtggttg cgatcttgtt catgttcaag ccacacggca ttgttcctcg ctcggtgctg 10440
atcttggatc ctatgctgtt gctgctgttg atgggcggca gccgctttgc ttaccgagca 10500
tggaaagaac atcgcctgta tggttctgcc cagttttccg gaaagccggt gctggtgctc 10560
ggcgcgggtg aggcagcgat tgccttgttg aaggatcttt ccaaaagccg tgaatggcat 10620
gtcgttgggt tgctggacga taagaaaacc atgcatggcc gagagctact gggcgtcaat 10680
gtgctggggt cgattgcgca attgccacag atcgctgcgg atttgtcggt caatcatgtg 10740
attgtggcca tgccatccgc gcgtcatcaa cgacgcaggg aaatcgtcga gctggcaagc 10800
agaaatgggc tgactgcgct cacggtgccg tcgtttgatg acctgatgag tggccacctg 10860
agcatggcac agattcggcc ggtcgaggtg gaggacttgc tggggcggga gccggtcagt 10920
ctcgatggag aggggctcca gcatttgatc gaggggcagg tgttgctgat tactggtgca 10980
ggtggttcca tcggttctga gttatgccgc caggtgctga aataccgtcc agcttgcctg 11040
gtctgcctgg atcagtcgga gtacgcgttg tatcggttgg agcaggagtt tgacaatctg 11100
gagtttgata cccgcattga atacgtggtt ggcgatgtca ggaacgcacg ccgggtgggg 11160
caggtgcttg gccgttatat gcccaaactg gtgttccatg ctgctgcgta taagcatgtg 11220
cctttgatgg agaaccgcaa tgtggcggaa tcattgtcaa ataatgtcag cggtacttac 11280
acgctcgccc aggcatgcaa aactgcaggg gttgccaagt tcgtgctgat ttccaccgat 11340
aaggcggtta atcccaccaa tgtgatgggg gccagcaagc gcctggcgga aatgatatgc 11400
caaggcctgc aggaggagtc gggtacgcgt tttatcgtgg tgcgctttgg caatgtgctg 11460
ggcagtagtg gcagtgtaat ccccaagttc cgtgagcaga ttgcggcggg cgggccaatt 11520
accgttaccc atcccgagat cactcgctat ttcatgtcca tcccggaggc gtgccagctg 11580
gtcatgcagg ctggattgat gggtggtggc ggggagatat ttgtgctgga tatgggagac 11640
cctgtgcgga ttgtggactt ggcccgtgat atgatccggt tatccgggct taatgaagat 11700
gacattcaga ttgtatactc tggcttgcgg cccggcgaaa agctgtacga ggaacttttg 11760
gctgacgacg agctcactgt accaacaccc cacgacaagc tacgtattgc cgtggcgcga 11820
agcgtggatg gtgcttgggt tcaggcattg ctgaaatgga tcgacagggc atcgctcata 11880
gatgaatctg tcatcaagca agagctgggc atgtgggtgg aggagtatgc aggggatatt 11940
catgccaatc catccatgat gttccccccc gagtcttcaa ccatacatta gaagaaagat 12000
agatagaaat ggcaaaaaaa attaccaagg cagtatttcc agtggcaggt ttagggacac 12060
gtttcctgcc agcaaccaag gcgagtccca aggaaatgtt gccaattgtg gataagcctc 12120
tgattcagta tgcagcagag gaggctgtgg ccgccggtgc taccgagctg atttttatta 12180
tcgggcgcaa caagcgcacc atcccggatc attttgataa gtccttcgag ctggaagcga 12240
cgcttgaggc aagcaagaaa accaaggtgc tggaagaaat ccgcaatatc ctgccaaaaa 12300
atgtttcctg catctatatt cgccaggccg aggcgcttgg tttggggcat gcggtattgc 12360
ttgccaagtc cgtggtcggc agcgagcctt tctctgtgat cctggccgat gaccttattg 12420
atgccgacaa acctgccatg cagcagatga cagagctgtt cgaccaagag ggtgtcagca 12480
ttctgggtgt cgaggatgtg gagcccagtg agacggcaag ctatggcatt gtggatgcga 12540
cagaggtgag tggcccgaat gtgttgcaat tgaatggcat tgtggaaaaa ccgcagccgg 12600
aagaagcgcc ctccaatctg gctgttgtcg gtcggtatat tctcacgcct gaaatttttg 12660
aatgcctgga gaacgtcaag ccgggcaagg gcggggaaat ccagttgact gatggcattg 12720
ccgccttgat ggaaaaacag aaaatcctgg cttaccgttt cgatgggaag cgctacgatt 12780
gcggcagcaa gctgggttat gtcaaggcga acgtcgagta ttccttgaag catgaggagt 12840
ttggcaaaga gtttgcccag tacttacgtg atctaaccaa gtagcagtcg tggtggtact 12900
tgagggtaac cccgatctca ttctgcagcg atccacgctg gtctcttctg aagaggaagt 12960
gaagcaggcg gtgacgaggg tggcgcagga aatcactgcc acgctaaggc aggaccaacc 13020
tctcgtcctg tgtgtcatgg gaggcggggt ggtattcacc gggcaattat tgccacagct 13080
ggttttccct ttggagttcg gttatgtgca ggccacccgc tatcacaacc ggacacatgg 13140
cgatgcccag ctggtgtgga aaatgaagcc cggggaggag gtgcgcggcc gtaccgtttt 13200
attgctcgat gatattctcg atgagggggt cacgctggca gaaatcaagg cgcagtgtct 13260
ggcactgggt gccagcaagg ttgtcgttgc ggtcttggtt gaaaaaatgc tggggcgggt 13320
caagccgatc agggctgatt tcgtcggact ggaggtgccg gaccagtatg tattcggatg 13380
cggaatggat gcctatgggt ggtggcgtaa tttgccggcc atttatgcca tgcaagggga 13440
agcttga 13447

Claims (22)

1.一种基因工程化的甲基菌(Methylobacillus)属的细菌，所述细菌修饰为灭活第一EPS基因簇和/或第二EPS基因簇；其中所述第一EPS基因簇包括由SEQ ID NO:174或177中存在的开放阅读框(ORF)定义的或与其直系同源的基因；并且其中所述第二EPS基因簇包括由SEQ ID NO:175或179中存在的开放阅读框(ORF)定义的或与其直系同源的基因。
2.根据权利要求1所述的基因工程化的细菌，其中，灭活所述第一EPS基因簇。
3.根据权利要求1或2所述的基因工程化的细菌，其中，灭活所述第二EPS基因簇。
4.根据权利要求1-3中任一项所述的基因工程化的细菌，其中，灭活所述第一EPS基因簇和所述第二EPS基因簇。
5.根据权利要求1-4中任一项所述的细菌，其中，所述第一EPS基因簇包括基因epsD、epsE、epsF、epsG、epsB、epsL、epsH、epsI、epsJ和epsS，或其直系同源物。
6.根据权利要求1-5中任一项所述的细菌，其中，所述第一EPS基因簇包括基因epsD、epsE、epsF和epsG或其直系同源物。
7.根据权利要求1-6中任一项所述的细菌，其中，所述第一EPS基因簇包括与SEQ IDNO:174或177的核苷酸序列具有至少50％序列同一性的核苷酸序列。
8.根据权利要求1-6中任一项所述的细菌，其中，所述第一EPS基因簇包括与SEQ IDNO:174的核苷酸序列具有至少50％序列同一性的核苷酸序列。
9.根据权利要求1-8中任一项所述的细菌，其中，所述第一EPS基因簇通过所述簇的部分或整个序列的缺失而灭活。
10.根据权利要求1-8中任一项所述的细菌，其中，所述第一EPS基因簇通过修饰启动子和/或核糖体结合位点区域导致缺乏基因表达而灭活。
11.根据权利要求1-10中任一项所述的细菌，其中，所述第二EPS基因簇包括与SEQ IDNO:175或179的核苷酸序列具有至少50％序列同一性的核苷酸序列。
12.根据权利要求1-10中任一项所述的细菌，其中，所述第二EPS基因簇包括与SEQ IDNO:175的核苷酸序列具有至少50％序列同一性的核苷酸序列。
13.根据权利要求1-12中任一项所述的细菌，其中，所述第二EPS基因簇通过所述簇的部分或整个序列的缺失而灭活。
14.根据权利要求1-12中任一项所述的细菌，其中，所述第二EPS基因簇通过修饰启动子和/或核糖体结合位点区域导致缺乏基因表达而灭活。
15.根据权利要求1-14中任一项所述的细菌，其中，编码涉及所述细菌中胞外多糖(EPS)生产的酶的所有内源基因被灭活，例如被删除。
16.根据权利要求1-15中任一项所述的细菌，其中，所述细菌选自鞭毛甲基菌(Methylobacillus flagellatus)、糖原甲基菌(Methylobacillusglycogenes)、草原甲基菌(Methylobacillus pratensis)、根际甲基菌(Methylobacillus rhizosphaerae)、草状甲基菌(Methylobacillusgramineus)、树状甲基菌(Methylobacillus arboreus)、隆凸甲基菌(Methylobacillus caricics)、食甲基甲基菌(Methylobacillusmethilovorans)和甲基菌属(Methylobacillus sp)。
17.根据权利要求1-15中任一项所述的细菌，其中，所述细菌选自鞭毛甲基菌和糖原甲基菌。
18.根据权利要求1-15中任一项所述的细菌，其中，所述细菌是鞭毛甲基菌。
19.根据权利要求1-15中任一项所述的细菌，其中，所述细菌是糖原甲基菌。
20.一种用于生产生物化学化合物的方法，包括：在合适的培养条件下，在包含还原的单碳化合物如甲醇，或不含碳-碳键的多碳化合物如二甲胺的培养基中培养根据权利要求1-19中任一项所述的细菌。
21.根据权利要求20所述的方法，其中，所述培养基包含甲醇。
22.根据权利要求20或21所述的方法，其中，所述培养在生物反应器中进行。
CN202180080543.7A 2020-10-02 2021-09-30 具有改进性能的基因修饰的甲基菌 Pending CN116635401A (zh)

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