CN116617586A - Light control system for ultraviolet crosslinking auxiliary infrared light irradiation, application and method - Google Patents
Light control system for ultraviolet crosslinking auxiliary infrared light irradiation, application and method Download PDFInfo
- Publication number
- CN116617586A CN116617586A CN202310597794.3A CN202310597794A CN116617586A CN 116617586 A CN116617586 A CN 116617586A CN 202310597794 A CN202310597794 A CN 202310597794A CN 116617586 A CN116617586 A CN 116617586A
- Authority
- CN
- China
- Prior art keywords
- illumination
- light source
- irradiation
- rhinitis
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004132 cross linking Methods 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims description 29
- 206010039083 rhinitis Diseases 0.000 claims abstract description 64
- 230000000638 stimulation Effects 0.000 claims abstract description 7
- 238000005286 illumination Methods 0.000 claims description 101
- 238000004088 simulation Methods 0.000 claims description 27
- 238000004422 calculation algorithm Methods 0.000 claims description 16
- 238000005457 optimization Methods 0.000 claims description 10
- 230000004907 flux Effects 0.000 claims description 9
- 238000000338 in vitro Methods 0.000 claims description 9
- 210000003928 nasal cavity Anatomy 0.000 claims description 9
- 230000001276 controlling effect Effects 0.000 claims description 8
- 238000004806 packaging method and process Methods 0.000 claims description 8
- 238000003491 array Methods 0.000 claims description 7
- 238000004364 calculation method Methods 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 6
- 238000012937 correction Methods 0.000 claims description 6
- 238000005520 cutting process Methods 0.000 claims description 6
- 238000002474 experimental method Methods 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 238000013135 deep learning Methods 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 3
- 238000009864 tensile test Methods 0.000 claims description 3
- 230000003760 hair shine Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 210000001519 tissue Anatomy 0.000 description 19
- 239000003814 drug Substances 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 210000002850 nasal mucosa Anatomy 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000013566 allergen Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000009169 immunotherapy Methods 0.000 description 3
- 239000002086 nanomaterial Substances 0.000 description 3
- 206010008479 Chest Pain Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010039085 Rhinitis allergic Diseases 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 201000010105 allergic rhinitis Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013527 convolutional neural network Methods 0.000 description 1
- 239000011889 copper foil Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 229940124581 decongestants Drugs 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000000544 hyperemic effect Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000008897 memory decline Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 210000001706 olfactory mucosa Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 210000001944 turbinate Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B45/00—Circuit arrangements for operating light-emitting diodes [LED]
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B47/00—Circuit arrangements for operating light sources in general, i.e. where the type of light source is not relevant
- H05B47/10—Controlling the light source
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0607—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0652—Arrays of diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
- Y02B20/00—Energy efficient lighting technologies, e.g. halogen lamps or gas discharge lamps
- Y02B20/40—Control techniques providing energy savings, e.g. smart controller or presence detection
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention discloses a light control system for ultraviolet crosslinking auxiliary infrared light irradiation, which comprises a hardware module and a software algorithm module, wherein the light control system is based on an FPGA (field programmable gate array) as a core controller, a general input/output interface is controlled to drive a light source, the light source is divided into two parts, one part is a 370nm ultraviolet light source array, the other part is a 650nm infrared light source array, and the whole stimulation step is that the ultraviolet light source array is firstly used for irradiation and then the infrared light source array is used for irradiation. The light control system for ultraviolet light crosslinking auxiliary infrared light irradiation can assist in treating rhinitis, and a light crosslinking treatment scheme with optimal rhinitis treatment effect under a double-light source irradiation mode is established so as to realize more effective treatment.
Description
Technical Field
The invention relates to the technical field of rhinitis treatment, in particular to a light regulating and controlling system for ultraviolet crosslinking auxiliary infrared light irradiation, and application and a method thereof.
Background
Rhinitis is an inflammation of the nasal mucosa and submucosal tissue. Symptoms of rhinitis are nasal obstruction, nasal discharge, decreased smell, discomfort of throat, headache, dizziness, and bleeding of nasal mucosa. The cause of rhinitis is allergic reaction between mast cells and sensitive substances, so that nasal mucosa is abnormally hyperemic. The clinical symptoms of rhinitis are different, the harm is extremely large, when the physiological functions of the nasal cavity are affected, respiratory disorder can occur, blood oxygen concentration is reduced, the functions and metabolism of other tissues and organs are affected, and some symptoms such as headache, dizziness, memory decline, chest pain, chest distress, mental retardation and the like are caused, so that the sleeping, working and learning are seriously affected. In addition, when rhinitis is not treated in time, olfactory disorders occur when the olfactory mucosa is affected, resulting in no smell. In summary, rhinitis is a condition that is extremely harmful to the physical health and daily life of a patient.
For the treatment of rhinitis, many treatment schemes have also emerged in recent years. On the premise of avoiding contacting with suspicious allergen, the current treatment methods of rhinitis are divided into three types of drug treatment, immunotherapy and operation treatment. The medicines for treating allergic rhinitis in the medicine treatment method are divided into five types, namely antihistamine medicines, mast cell stabilizers, corticosteroids, local decongestants and anticholinergic medicines; immunotherapy, also known as desensitization, is the alleviation of allergic symptoms by inoculating allergens to tolerize patients; surgical treatment includes intranasal tissue excision and laser irradiation.
The existing rhinitis treatment method has a plurality of defects, and although the drug treatment can effectively control the symptoms of allergic rhinitis, the purpose of radical treatment can not be achieved; immunotherapy can only alleviate allergic symptoms, and the therapeutic effect on patients with multiple allergens is poor; the disadvantage of intranasal tissue excision is that there is much scabbing after surgery, bleeding is easy, and turbinate atrophy is often caused. In summary, the existing method for treating rhinitis has the problems of long duration, short duration of effect, multiple side effects and the like, and has an unsatisfactory effect on rhinitis treatment.
Disclosure of Invention
The invention aims to provide a light control system for ultraviolet light crosslinking auxiliary infrared light irradiation, which can assist in treating rhinitis, establish a light crosslinking treatment scheme with optimal rhinitis treatment effect under a double-light-source irradiation mode so as to realize more effective treatment, accurately irradiate the inside of the nose by adopting two different wavelength light stimulation methods, and experiment the optimal irradiation of two light sources by using an artificial intelligent optimization algorithm, so that the rhinitis can be effectively and rapidly relieved, and the data can be used as a database mode to realize prediction and maintain an optimal irradiation mode for new rhinitis in the future.
The invention provides a light modulation and control system for ultraviolet crosslinking auxiliary infrared light irradiation, which comprises a hardware module and a software algorithm module, wherein the light modulation and control system is based on an FPGA (field programmable gate array) as a core controller, a general input/output interface is controlled to drive a light source, the light source is divided into two parts, one part of the light source is a 370nm ultraviolet light source array, the other part of the light source is a 650nm infrared light source array, and the whole stimulation step is that the ultraviolet light source array is firstly used for irradiation and then the infrared light source array is used for irradiation.
Preferably, the hardware module comprises an FPGA control module, a power supply module and an optode array module, wherein the FPGA control module controls the general input/output interface through an algorithm to control the illuminant array; the power supply module adopts a power supply module carried by the FPGA to effectively supply power to the whole system; the light pole array module realizes different arrangements of light sources through different packaging forms, and the ultraviolet light source array and the infrared light source array are alternately arranged.
Preferably, the input end of the software algorithm module comprises the light intensity, the irradiation mode, the irradiation time and the irradiation mode of the ultraviolet light source and the infrared light source, and the optimal biological tissue elastic modulus coefficient is determined through the parameters of the ultraviolet light source and the infrared light source.
An application of a light control system of ultraviolet light crosslinking auxiliary infrared light irradiation in a medical device for treating rhinitis.
A medical device for treating rhinitis is provided with a light regulating and controlling system for ultraviolet crosslinking auxiliary infrared light irradiation.
Preferably, the medical device comprises a main control module, an LED driving module, an LED array and a PC; the main control module is used for receiving the data of the PC, analyzing the data and sending the data content to the LED driving module; the LED driving module generates PWM signals with different duty ratios under the control of the main control module to drive the LED array to generate different illumination intensities; the LED arrays are distributed in a strip shape, each individual LED is effectively controlled, any LED in the LED arrays can be controlled, and implementation of different illumination control schemes is met.
A method of using a medical device for treating rhinitis, comprising the steps of:
step one: determining the Young modulus of a rhinitis focus target and the position of the rhinitis focus in the nasal cavity, and performing joint simulation by using MATLAB or ANSYS to obtain an equation of illumination control and Young modulus:
wherein E is Young's modulus, T is illumination time in unit period, phi is radiant flux power, x is illumination mode, subscript UVA all represent ultraviolet light illumination, subscript IR all represent ultraviolet light illumination, and illumination intensity, illumination time, illumination area and illumination mode are preliminarily determined through simulation calculation;
performing joint simulation by using MATLAB or ANSYS, and obtaining the independent variable of Young modulus E after ultraviolet irradiation by using a deep learning algorithm UVA And infrared illumination control, the dependent variable is the equation of Young's modulus:
wherein E is Young's modulus, E UVA For Young's modulus after ultraviolet irradiation, T is the illumination time in unit period, phi is the radiant flux power, x is the illumination mode including continuous illumination and pulsed illumination, and the subscript NIR both represent near infrared light irradiation, passingThe simulation calculation preliminarily determines illumination intensity, illumination time, illumination area and illumination mode, and trains an artificial intelligent algorithm model aiming at optimal light source parameters of different light source combinations through various parameters;
step two: the simulation result data are exported and input into a PC, a serial data stream is generated by the PC according to an illumination control mode given by simulation, and the PC controls the LED driving module through serial communication;
step three: simulating the rhinitis focus condition by using a related instrument, and fixing the strip-shaped LED array at the nasal cavity focus;
step four: the main control module receives data sent by the PC through serial port communication, controls the LED driving module, and further controls the luminous modes and luminous intensities of different LEDs on the LED array to generate specific irradiation positions and irradiation light intensities;
step five: after irradiation, confirming the treatment condition of the rhinitis focus, performing bacterial collection and analysis on the focus area by using a swab, performing in-vitro cutting on the rhinitis focus part, performing elastic modulus measurement, comparing the measurement result with the simulation result, feeding back the result to a PC (personal computer), and performing dynamic optimization in the manner that the PC optimizes illumination control and adjusts the next time.
Preferably, the specific implementation steps of the fifth step are as follows:
(1) Cutting and in vitro separating rhinitis focus tissues formed by illumination;
(2) Using a tissue tensile tester to carry out tensile test on the cut in-vitro tissue, and calculating Young modulus of the tissue by measuring stress and deformation of the tissue;
(3) And feeding back the result to control software of the PC, and carrying out illumination correction according to the deviation direction and degree measured by simulation and experiment, wherein correction parameters are applied to the next illumination, so that the method is dynamically adjusted.
The ultraviolet crosslinking auxiliary infrared irradiation light regulating and controlling system, application and method have the advantages and positive effects that:
1. compared with the existing method for treating rhinitis, the method has the advantages of long duration, short effect duration, multiple side effects and the like, the method for treating rhinitis is effective for a long time and free of wounds, the convenience of rhinitis treatment is greatly improved, the effective time of rhinitis treatment is prolonged, and illumination can be flexibly adjusted according to different parts and different target mechanical properties.
2. The high-controllability light source and the dynamic feedback illumination control mechanism enable illumination to be more accurate, controllable, convenient and comprehensive.
The technical scheme of the invention is further described in detail through the drawings and the embodiments.
Drawings
FIG. 1 is a schematic diagram of a power supply module in an ultraviolet crosslinking auxiliary infrared irradiation light control system according to the present invention;
FIG. 2 is a schematic view of an optoarray module in an UV-crosslinking assisted IR irradiation system according to the present invention;
FIG. 3 is a schematic diagram of a software algorithm module in a light control system with UV-crosslinking assisted IR irradiation according to the present invention;
FIG. 4 is a block diagram of an illumination algorithm of different combinations of light sources in an embodiment of the present invention;
FIG. 5 is a schematic view showing the overall structure of a medical device for treating rhinitis according to the present invention;
FIG. 6 is a flow chart of a method of using a medical device for treating rhinitis according to the present invention;
fig. 7 is a flowchart showing steps of a method for using a medical device for treating rhinitis according to the present invention.
Detailed Description
The technical scheme of the invention is further described below through the attached drawings and the embodiments.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The terms "first," "second," and the like, as used herein, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", etc. are used merely to indicate relative positional relationships, which may also be changed when the absolute position of the object to be described is changed.
Examples
The light modulation and control system comprises a hardware module and a software algorithm module, wherein the hardware module comprises an FPGA control module, a power supply module and a light pole array module, and the FPGA control module controls a general input/output interface through an algorithm to control a light source array to generate illumination modes with different frequencies, different wavelengths and other parameters; the purpose of adopting the FPGA platform is to finally realize the research and the integration of the whole control chip. The FPGA control module, FPGA (Field Programmable GateArray, i.e. field programmable gate array) is a product of further development on the basis of PAL, GAL, CPLD and other programmable devices, and is a semi-custom circuit in the field of Application Specific Integrated Circuits (ASICs), which not only solves the defect of custom circuits, but also overcomes the defect of limited gate circuits of the original programmable devices. The advantage of multiple general input/output interfaces of the FPGA is utilized to effectively control the light source array module.
The power supply module is shown with reference to fig. 1, and the power supply module adopts a power supply module of an FPGA to effectively supply power to the whole system. The FPGA board is provided with 1 external power input port (DC_IN), a standard direct-current power socket is adopted, and a DC-DC chip (JW 5060T) is arranged on the FPGA board and used for providing an efficient and stable 5V power supply for the development board. Because of the adoption of the DC-DC chip, the power supply range of the development board is quite wide, and the power can be basically supplied in the output range of DC 6-16V.
The light pole array module realizes different arrangements of light sources through different packaging forms, and the ultraviolet light source array and the infrared light source array are alternately arranged.
The light pole array module is shown with reference to fig. 2, the LED chip is packaged by 0201/01005/0402, different arrangements of light sources are realized through different packaging forms, the ultraviolet light source array and the infrared light source array are alternately arranged, a layer of nano material can be placed on the surface of the infrared light source array to realize the switching of the light source wavelength, and if the nano material is not placed, only the algorithm is required to be calibrated. The control mode comprises the following steps: single LED, LED row and LED brightness gradient regulation. A printed circuit board with high reliability and excellent flexibility, which is manufactured by etching a circuit formed on a copper foil using a circuit board using a polyester film or polyimide as a base material, can generate different light intensities (radiant flux powers) for each LED. Under the arrangement structure, the LED chips can be controlled in a row mode, so that the LED light intensity (radiant flux power) of different rows is different, or a dynamic effect is formed, and the LEDs are sequentially lightened from the outer side to the inner side; the LED chip is also provided with 01005 packaging and 0402 packaging, wherein the 01005 packaging is smaller than the 0201 packaging in volume and occupies a smaller area of the circuit board, so that LEDs with higher density are integrated on the circuit board; the use of 01005 such smaller volume packaged LEDs allows for finer adjustment of the brightness (radiant flux power) for different locations.
The software algorithm module only depends on the main control module to realize the optimization algorithm, the input end of the software algorithm module comprises the light intensity, the irradiation mode, the irradiation time and the irradiation mode in the light source array of the ultraviolet light source and the infrared light source, and the optimal biological tissue elastic modulus coefficient is determined through the parameters of the ultraviolet light source and the infrared light source.
Software algorithm module referring to fig. 3, the modulus of elasticity coefficient is an evaluation index of performance in both the output and rhinitis tissues. And taking a single light source in the whole light source array as a pixel point, and realizing optimal illumination through different illumination modes. As shown in FIG. 4, the illumination algorithm of different combinations of light sources mainly comprises two parts, wherein the first part of hardware is used for initializing an internal machine, and variables to be determined in the initialization process are as follows: the method comprises the steps of (1) dividing the brightness of an array into 1 (bright) and 0 (dead), dividing the other pixel into 4 (bright), 3 (sub-bright), 2 (gradually bright), 1 (dark) and 0 (dead), defining the brightness degree of each light source as a pixel point, performing inverse binarization and inverse gray processing on the light source arrays of the pixel levels, completing inverse operation of image analysis, and finally generating images of different light source combinations.
For each LED light source, the brightness is determined by the current I, i=0 when the LED lamp is off, i=70 mA when the LED lamp is brightest, and this parameter can be set according to the current range of the LED. The current formula for setting up the model is shown in (1):
meanwhile, each LED has a voltage value U, but the voltage is kept between 3.3 and 5V, the irradiation frequency f is changed in the range of 0 to 32MHz, and the irradiation angle is fixed by default. Taking an 8 x 8 light source as an example, storing five parameters of current, voltage, activation voltage, irradiation frequency and illumination angle into an 8 x 8 array respectively, wherein each parameter is regarded as one channel of an image, thus forming an 8 x 8 image with 5 channels, taking the generated data as an analog image, sending the analog image into a convolutional neural network for training, inputting the generated analog image, outputting the monitored bioelectricity of 10-14pA, carrying out network classification through ResNet-50, sending the analog image into the network, and dividing the classes into five classes of 10pA, 11pA, 12pA, 13pA and 14pA with 1pA as intervals, wherein residual ideas in the ResNet-50 are well reflected, different weights Ws are introduced into an input end to better improve classification accuracy, and the formula (2) shows that:
y＝F(x，{W i })+Ws x (2)
the light regulation and control system is based on FPGA as a core controller, drives a light source through controlling a general input/output interface, wherein the light source is divided into two parts, one part of the light source is a 370nm ultraviolet light source array, the other part of the light source is a 650nm infrared light source array, and the whole stimulation step is that the ultraviolet light source array is firstly used for irradiation, and then the infrared light source array is used for irradiation.
The ultraviolet irradiation realizes the early stimulation of the mucous membrane position of rhinitis so as to realize the rapid fibrosis of pathological tissues at the mucous membrane position, and then the effective irradiation of rhinitis is realized at the fastest speed through the infrared irradiation. In the process of switching two light sources, two modes are adopted to realize the rapidness and the optimization. The first mode is that when ultraviolet light irradiates, the infrared light source is also turned on, but the surface of the infrared light source is covered with a layer of nano material to realize the conversion from infrared to ultraviolet, thus the early irradiation is realized rapidly. After the ultraviolet irradiation is finished, the irradiation treatment is performed by infrared rays. The other mode is that the ultraviolet light source and the infrared light source are alternately turned on, and parameters such as the turned-on light intensity, the illumination mode, the illumination array combination mode, the illumination time and the like are optimized by adopting an artificial intelligent optimization algorithm, an optimal illumination parameter range is optimized in an early experiment, and an optimal key parameter is detected through a rhinitis detection instrument in the actual illumination process, so that data storage is reserved for later optimization, and continuous updating and optimization of an illumination mode are realized.
The main core of the two illumination modes is that ultraviolet light irradiation can influence the elastic modulus of nasal mucosa, so that a skin crosslinking effect is generated at a focus, and the crosslinking effect can influence the effect of later infrared irradiation. The method comprises the steps of firstly irradiating the nasal cavity by an ultraviolet LED to generate a skin crosslinking effect, and then irradiating the nasal cavity by an infrared LED to achieve the purposes of optimizing the treatment depth and improving the treatment effect.
An application of a light control system of ultraviolet light crosslinking auxiliary infrared light irradiation in a medical device for treating rhinitis. A medical device for treating rhinitis is provided with a light regulating and controlling system for ultraviolet crosslinking auxiliary infrared irradiation.
The medical device for treating rhinitis comprises a main control module, an LED driving module, an LED array and a PC; the main control module is used for receiving the data of the PC, analyzing the data and sending the data content to the LED driving module; the LED driving module generates PWM signals with different duty ratios under the control of the main control module to drive the LED array to generate different illumination intensities; the LED arrays are distributed in a strip shape, each individual LED is effectively controlled, any LED in the LED arrays can be controlled, and implementation of different illumination control schemes is met.
A method of using a medical device for treating rhinitis, comprising the steps of:
step one: determining the Young modulus of a rhinitis focus target and the position of the rhinitis focus in the nasal cavity, and performing joint simulation by using MATLAB or ANSYS to obtain an equation of illumination control and Young modulus:
wherein E is Young's modulus, T is illumination time in unit period, phi is radiant flux power, x is illumination mode, subscript UVA all represent ultraviolet light illumination, subscript IR all represent ultraviolet light illumination, and illumination intensity, illumination time, illumination area and illumination mode are preliminarily determined through simulation calculation;
performing joint simulation by using MATLAB or ANSYS, and obtaining the independent variable of Young modulus E after ultraviolet irradiation by using a deep learning algorithm UVA And infrared illumination control, the dependent variable is the equation of Young's modulus:
wherein E is Young's modulus, E UVA Is meridian passageYoung modulus after ultraviolet irradiation, T is illumination time in a unit period, phi is radiant flux power, x is illumination mode comprising continuous illumination and pulse illumination, subscript NIR represents near infrared illumination, illumination intensity, illumination time, illumination area and illumination mode are preliminarily determined through simulation calculation, and an artificial intelligent algorithm model aiming at optimal light source parameters of different light source combinations is trained through various parameters.
Firstly, determining the Young modulus of the rhinitis as k, and carrying out MATLAB or ANSYS joint simulation by taking the Young modulus of the rhinitis as a target to preliminarily determine the illumination control mode. The simulation shows that if the Young modulus is taken as a target, the maximum illumination intensity of the innermost measuring aperture is required to be gradually decreased towards the outside. The key of the process is that the illumination control data which can be received by the PC is obtained through simulation. And (3) exporting data comprising illumination time, illumination intensity, illumination area and illumination mode from MALAB, and importing the data packet into control software of a PC.
Step two: and outputting simulation result data to a PC, generating serial data flow by the PC according to an illumination control mode given by simulation, and controlling the LED driving module by the PC through serial communication.
The control software on the PC analyzes the data packet, converts the data packet into a data stream, transmits the data stream to the main control chip through the serial port, and continuously transmits the data stream according to a time sequence, so that the LED array can continuously emit pulse illumination weakened from outside to inside.
Step three: the related instrument is used for simulating the disease focus condition of the rhinitis, and the strip-shaped LED array is fixed at the disease focus of the nasal cavity.
The main control chip receives data sent by the PC, unpacks and analyzes the data, and sends the data to a data interface port of the LED driving chip through the general IO input/output interface, and the STM32 has a large number of IO interfaces because of more control LEDs, so that a plurality of LED driving chips can be controlled by a single main control chip to control each LED.
Step four: the main control module receives data sent by the PC through serial communication and controls the LED driving module, so that the light emitting modes and the light emitting intensities of different LEDs on the LED array are controlled, and specific irradiation positions and specific irradiation light intensities are generated.
The LED driving chip obtains the data sent by the main control chip, analyzes the data content, controls the LEDs on the output interface, and the data comprise PWM modulation data required by the LEDs on the data interface and the data of the on-off time of the interface, so that each luminous point on the LED matrix can be effectively controlled, and further, the focus tissue is effectively irradiated according with the vibration-proof requirement.
Step five: after irradiation, confirming the treatment condition of the rhinitis focus, performing bacterial collection and analysis on the focus area by using a swab, performing in-vitro cutting on the rhinitis focus part, performing elastic modulus measurement, comparing the measurement result with the simulation result, feeding back the result to a PC (personal computer), and performing dynamic optimization in the manner that the PC optimizes illumination control and adjusts the next time.
The specific implementation steps of the fifth step are as follows:
(1) Cutting and in vitro separating rhinitis focus tissues formed by illumination;
(2) Using a tissue tensile tester to carry out tensile test on the cut in-vitro tissue, and calculating Young modulus of the tissue by measuring stress and deformation of the tissue;
(3) And feeding back the result to control software of the PC, and carrying out illumination correction according to the deviation direction and degree measured by simulation and experiment, wherein correction parameters are applied to the next illumination, so that the method is dynamically adjusted.
Therefore, the invention adopts the light regulating and controlling system, the application and the method for ultraviolet light crosslinking auxiliary infrared light irradiation, can assist in treating rhinitis, establishes a photocrosslinking treatment scheme with optimal rhinitis treatment effect under a double-light source irradiation mode, realizes more effective treatment, adopts two different wavelength light stimulation methods to accurately irradiate the inside of the nose, adopts an artificial intelligent optimization algorithm to experiment the optimal irradiation of two light sources, can effectively and quickly relieve rhinitis, and adopts the data as a database mode, and can realize prediction and maintain an optimal irradiation mode for new rhinitis in the future.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention and not for limiting it, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that: the technical scheme of the invention can be modified or replaced by the same, and the modified technical scheme cannot deviate from the spirit and scope of the technical scheme of the invention.
Claims (8)
1. The utility model provides a light modulation and control system that ultraviolet light crosslinked auxiliary infrared light shines, includes hardware module and software algorithm module, its characterized in that: the light control system is based on an FPGA as a core controller, a general input/output interface is controlled to drive a light source, the light source is divided into two parts, one part of the light source is a 370nm ultraviolet light source array, the other part of the light source is a 650nm infrared light source array, and the whole stimulation step is that the ultraviolet light source array is firstly used for irradiation, and then the infrared light source array is used for irradiation.
2. The light control system for ultraviolet crosslinking-assisted infrared irradiation of claim 1, wherein: the hardware module comprises an FPGA control module, a power supply module and an optode array module, wherein the FPGA control module controls the general input/output interface through an algorithm to control the illuminant array; the power supply module adopts a power supply module carried by the FPGA to effectively supply power to the whole system; the light pole array module realizes different arrangements of light sources through different packaging forms, and the ultraviolet light source array and the infrared light source array are alternately arranged.
3. The light control system for ultraviolet crosslinking-assisted infrared irradiation of claim 1, wherein: the input end of the software algorithm module comprises the light intensity, the irradiation mode, the irradiation time and the irradiation mode in the light source array of the ultraviolet light source and the infrared light source, and the optimal biological tissue elastic modulus coefficient is determined through the parameters of the ultraviolet light source and the infrared light source.
4. Use of a light management system for ultraviolet light cross-linking assisted infrared irradiation according to any one of claims 1-3 in a medical device for the treatment of rhinitis.
5. A medical device for treating rhinitis, characterized in that: the medical device is provided with the light regulating and controlling system for ultraviolet light crosslinking auxiliary infrared light irradiation according to any one of claims 1-3.
6. A medical device for treating rhinitis according to claim 5, wherein: the medical device comprises a main control module, an LED driving module, an LED array and a PC; the main control module is used for receiving the data of the PC, analyzing the data and sending the data content to the LED driving module; the LED driving module generates PWM signals with different duty ratios under the control of the main control module to drive the LED array to generate different illumination intensities; the LED arrays are distributed in a strip shape, each individual LED is effectively controlled, any LED in the LED arrays can be controlled, and implementation of different illumination control schemes is met.
7. A method of using a medical device for the treatment of rhinitis as claimed in any of claims 5 to 6, comprising the steps of:
step one: determining the Young modulus of a rhinitis focus target and the position of the rhinitis focus in the nasal cavity, and performing joint simulation by using MATLAB or ANSYS to obtain an equation of illumination control and Young modulus:
wherein E is Young's modulus, T is illumination time in unit period, phi is radiant flux power, x is illumination mode, subscript UVA all represent ultraviolet light illumination, subscript IR all represent ultraviolet light illumination, and illumination intensity, illumination time, illumination area and illumination mode are preliminarily determined through simulation calculation;
joint simulation using MATLAB or ANSYS, usingThe deep learning algorithm obtains the independent variable of Young's modulus E after ultraviolet irradiation UVA And infrared illumination control, the dependent variable is the equation of Young's modulus:
wherein E is Young's modulus, E UVA For Young modulus after ultraviolet irradiation, T is illumination time in a unit period, phi is radiant flux power, x is illumination mode comprising continuous illumination and pulse illumination, subscript NIR represents near infrared illumination, illumination intensity, illumination time, illumination area and illumination mode are preliminarily determined through simulation calculation, and an artificial intelligent algorithm model aiming at optimal light source parameters of different light source combinations is trained through various parameters;
step two: the simulation result data are exported and input into a PC, a serial data stream is generated by the PC according to an illumination control mode given by simulation, and the PC controls the LED driving module through serial communication;
step three: simulating the rhinitis focus condition by using a related instrument, and fixing the strip-shaped LED array at the nasal cavity focus;
step four: the main control module receives data sent by the PC through serial port communication, controls the LED driving module, and further controls the luminous modes and luminous intensities of different LEDs on the LED array to generate specific irradiation positions and irradiation light intensities;
step five: after irradiation, confirming the treatment condition of the rhinitis focus, performing bacterial collection and analysis on the focus area by using a swab, performing in-vitro cutting on the rhinitis focus part, performing elastic modulus measurement, comparing the measurement result with the simulation result, feeding back the result to a PC (personal computer), and performing dynamic optimization in the manner that the PC optimizes illumination control and adjusts the next time.
8. The method of claim 7, wherein the step five is performed as follows:
(1) Cutting and in vitro separating rhinitis focus tissues formed by illumination;
(2) Using a tissue tensile tester to carry out tensile test on the cut in-vitro tissue, and calculating Young modulus of the tissue by measuring stress and deformation of the tissue;
(3) And feeding back the result to control software of the PC, and carrying out illumination correction according to the deviation direction and degree measured by simulation and experiment, wherein correction parameters are applied to the next illumination, so that the method is dynamically adjusted.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310597794.3A CN116617586B (en) | 2023-05-25 | 2023-05-25 | Light control system for ultraviolet crosslinking auxiliary infrared light irradiation, application and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310597794.3A CN116617586B (en) | 2023-05-25 | 2023-05-25 | Light control system for ultraviolet crosslinking auxiliary infrared light irradiation, application and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116617586A true CN116617586A (en) | 2023-08-22 |
| CN116617586B CN116617586B (en) | 2024-01-23 |
Family
ID=87641266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310597794.3A Active CN116617586B (en) | 2023-05-25 | 2023-05-25 | Light control system for ultraviolet crosslinking auxiliary infrared light irradiation, application and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116617586B (en) |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050107853A1 (en) * | 2003-10-15 | 2005-05-19 | Yosef Krespi | Control of rhinosinusitis-related, and other microorganisms in the sino-nasal tract |
| WO2005110397A1 (en) * | 2004-05-07 | 2005-11-24 | The Regents Of The University Of California | Treatment of myopia |
| US20090227118A1 (en) * | 2008-03-06 | 2009-09-10 | Tokyo Electron Limited | Method for removing a pore-generating material from an uncured low-k dielectric film |
| CN102179011A (en) * | 2011-03-04 | 2011-09-14 | 赵广 | Infrared-ultraviolet composite therapeutic apparatus |
| WO2012172821A1 (en) * | 2011-06-16 | 2012-12-20 | Ｓｂｉファーマ株式会社 | Therapeutic agent for allergic rhinitis |
| US20140330334A1 (en) * | 2013-01-15 | 2014-11-06 | ElectroCore, LLC | Mobile phone for treating a patient with seizures |
| CN106798727A (en) * | 2016-12-29 | 2017-06-06 | 上海交通大学 | A kind of utilization infrared light increases the medication of sequences of small interfering RNAs bioactivity in skin |
| WO2018090840A1 (en) * | 2016-11-21 | 2018-05-24 | 上海市第五人民医院 | Phototherapy device and method for use in metabolic disease |
| WO2019222605A1 (en) * | 2018-05-18 | 2019-11-21 | Northwestern University | Devices and methods for light delivery |
| WO2020180696A1 (en) * | 2019-03-01 | 2020-09-10 | Paradromics, Inc. | Systems, devices, and methods for tissue layer removal |
| KR20200144623A (en) * | 2019-06-18 | 2020-12-30 | (주)썬웨이브 | Method for Inhibiting Fungus Growth and Sporulation Using Mixed Light Irradiation |
| CN114466490A (en) * | 2022-01-20 | 2022-05-10 | 北京工业大学 | Single-point control device for light source array |
| WO2022267076A1 (en) * | 2021-06-22 | 2022-12-29 | 中国科学院苏州生物医学工程技术研究所 | Rhinitis phototherapy instrument |
| KR20230088935A (en) * | 2021-12-13 | 2023-06-20 | 한국광기술원 | A patch-type rhinitis treatment system using laser beam and optical module manufacturing method therein |
-
2023
- 2023-05-25 CN CN202310597794.3A patent/CN116617586B/en active Active
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050107853A1 (en) * | 2003-10-15 | 2005-05-19 | Yosef Krespi | Control of rhinosinusitis-related, and other microorganisms in the sino-nasal tract |
| WO2005110397A1 (en) * | 2004-05-07 | 2005-11-24 | The Regents Of The University Of California | Treatment of myopia |
| US20090227118A1 (en) * | 2008-03-06 | 2009-09-10 | Tokyo Electron Limited | Method for removing a pore-generating material from an uncured low-k dielectric film |
| CN102179011A (en) * | 2011-03-04 | 2011-09-14 | 赵广 | Infrared-ultraviolet composite therapeutic apparatus |
| WO2012172821A1 (en) * | 2011-06-16 | 2012-12-20 | Ｓｂｉファーマ株式会社 | Therapeutic agent for allergic rhinitis |
| US20140330334A1 (en) * | 2013-01-15 | 2014-11-06 | ElectroCore, LLC | Mobile phone for treating a patient with seizures |
| WO2018090840A1 (en) * | 2016-11-21 | 2018-05-24 | 上海市第五人民医院 | Phototherapy device and method for use in metabolic disease |
| CN106798727A (en) * | 2016-12-29 | 2017-06-06 | 上海交通大学 | A kind of utilization infrared light increases the medication of sequences of small interfering RNAs bioactivity in skin |
| WO2019222605A1 (en) * | 2018-05-18 | 2019-11-21 | Northwestern University | Devices and methods for light delivery |
| WO2020180696A1 (en) * | 2019-03-01 | 2020-09-10 | Paradromics, Inc. | Systems, devices, and methods for tissue layer removal |
| KR20200144623A (en) * | 2019-06-18 | 2020-12-30 | (주)썬웨이브 | Method for Inhibiting Fungus Growth and Sporulation Using Mixed Light Irradiation |
| WO2022267076A1 (en) * | 2021-06-22 | 2022-12-29 | 中国科学院苏州生物医学工程技术研究所 | Rhinitis phototherapy instrument |
| KR20230088935A (en) * | 2021-12-13 | 2023-06-20 | 한국광기술원 | A patch-type rhinitis treatment system using laser beam and optical module manufacturing method therein |
| CN114466490A (en) * | 2022-01-20 | 2022-05-10 | 北京工业大学 | Single-point control device for light source array |
Non-Patent Citations (3)
| Title |
|---|
| 吴双;徐菊;高卫民;王文思;: "活性钎焊电子浆料流变性能及丝印质量的研究", 电子元件与材料, no. 05 * |
| 火英明;陆芝敏;潘秋贤;张素芬;: "鼻用糖皮质激素与激光照射治疗变应性鼻炎", 中国实用医药, no. 13 * |
| 肖婷;杨河林;张国平;雷丽文;曾繁清;: "碳纳米管的多光谱兼容衰减特性研究", 光谱学与光谱分析, no. 04 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116617586B (en) | 2024-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1871476B1 (en) | Probe device for photobiomodulation of tissue lining a body cavity | |
| CN107537097B (en) | Based on can automatic Modulation laser parameter in real time laser therapeutic apparantus and its application method | |
| EP1982747A1 (en) | Portable device | |
| US20070021640A1 (en) | Method and apparatus for application of light to gums | |
| JP2007520285A (en) | Method and apparatus for treating mammalian tissue | |
| JP2008541954A (en) | Tissue treatment apparatus and method | |
| KR20120009571A (en) | System and method for skin treatment based on led | |
| WO2018035919A1 (en) | Cosmetic method on the basis of led light biological skin care and cosmetic device | |
| CN204502144U (en) | A kind of multifunctional helmet | |
| CN115591131A (en) | Myopia prevention and control device and control method thereof | |
| CN110180085B (en) | Direct-insertion type semiconductor red light internal-emission rhinitis auxiliary phototherapy instrument | |
| CN115715849A (en) | Brain cell injury repair cap, system and control method based on intelligent phototherapy | |
| CN116617586B (en) | Light control system for ultraviolet crosslinking auxiliary infrared light irradiation, application and method | |
| EP1988967A2 (en) | Method and apparatus for application of light to tissue | |
| CN201308726Y (en) | Brain strengthening machine capable of activating brain by near-infrared light | |
| CN108785863A (en) | Ultraviolet therapeutic and method for disinfection | |
| CN106362304A (en) | Intelligent photon therapeutic instrument and control method thereof | |
| CN204502157U (en) | A kind of Novel head cover | |
| CN200984244Y (en) | Portable tooth whitening instrument | |
| CN218684923U (en) | Control system for corneal local cross-linking | |
| CN106310537B (en) | A kind of smooth powered skin treatment and beauty appliance | |
| KR102470632B1 (en) | Leukoplakia curing apparatus | |
| CN217868909U (en) | Take red blue light or infrared light struck carbon dioxide cell culture case | |
| CN116602265B (en) | Intelligent control system and method for building keloid animal model | |
| TWI847892B (en) | An optimized parameter adjustment method and its system for the use in photobiomodulation therapy thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |