CN116617532A - Medical polytetrafluoroethylene eight-lumen tube and preparation method thereof - Google Patents
Medical polytetrafluoroethylene eight-lumen tube and preparation method thereof Download PDFInfo
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- CN116617532A CN116617532A CN202310405599.6A CN202310405599A CN116617532A CN 116617532 A CN116617532 A CN 116617532A CN 202310405599 A CN202310405599 A CN 202310405599A CN 116617532 A CN116617532 A CN 116617532A
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- 239000004810 polytetrafluoroethylene Substances 0.000 title claims abstract description 72
- 229920001343 polytetrafluoroethylene Polymers 0.000 title claims abstract description 72
- -1 polytetrafluoroethylene Polymers 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 238000005245 sintering Methods 0.000 claims description 63
- 238000001125 extrusion Methods 0.000 claims description 39
- 239000000463 material Substances 0.000 claims description 23
- 239000006185 dispersion Substances 0.000 claims description 20
- 239000011347 resin Substances 0.000 claims description 20
- 229920005989 resin Polymers 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 10
- 238000003825 pressing Methods 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 229910001220 stainless steel Inorganic materials 0.000 claims description 8
- 239000010935 stainless steel Substances 0.000 claims description 8
- 230000006835 compression Effects 0.000 claims description 5
- 238000007906 compression Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 238000000465 moulding Methods 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 230000008901 benefit Effects 0.000 abstract description 9
- 230000023597 hemostasis Effects 0.000 abstract description 8
- 230000036407 pain Effects 0.000 abstract description 6
- 238000002690 local anesthesia Methods 0.000 abstract description 4
- 238000002601 radiography Methods 0.000 abstract description 4
- 230000009467 reduction Effects 0.000 abstract description 4
- 238000009423 ventilation Methods 0.000 abstract description 4
- 210000004907 gland Anatomy 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 239000012752 auxiliary agent Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920006351 engineering plastic Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/09—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
- B29C48/11—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels comprising two or more partially or fully enclosed cavities, e.g. honeycomb-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0009—Making of catheters or other medical or surgical tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/001—Combinations of extrusion moulding with other shaping operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/001—Combinations of extrusion moulding with other shaping operations
- B29C48/0011—Combinations of extrusion moulding with other shaping operations combined with compression moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
- B29C67/02—Moulding by agglomerating
- B29C67/04—Sintering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0036—Multi-lumen catheters with stationary elements with more than four lumina
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
Abstract
The invention discloses a medical polytetrafluoroethylene eight-cavity tube and a preparation method thereof, the medical polytetrafluoroethylene eight-cavity tube comprises a tube body, the tube body is provided with eight cavity channels, each cavity channel comprises 1 main cavity channel, 1 secondary cavity channel and 6 auxiliary cavity channels, the eight cavity channels extend along the axial direction of the tube body and are not communicated with each other, and the diameter of each cavity channel is 0.35-1.95mm. The pipe body prepared by the invention comprises eight channels, the eight channels comprise main channels, secondary channels and auxiliary channels, the channels are not communicated with each other along the axial direction, the wall thickness is uniform, the size of the channels can meet various functions, such as drainage, ventilation, hemostasis, local anesthesia, radiography and the like, and the pipe body can simultaneously perform operations such as hemostasis, drainage, transfusion and the like, and has the advantages of small damage, small occupied space, pain reduction of patients and the like.
Description
Technical Field
The invention belongs to the technical field of manufacturing of polytetrafluoroethylene tubes, and particularly relates to a medical polytetrafluoroethylene eight-cavity tube and a preparation method thereof.
Background
With the development of modern medicine and medical technology, medical plastic products are widely used in various fields of modern medicine due to their excellent characteristics. At present, high-end medical products in China lack and huge market demands, particularly show outstanding aspects of high-end medical catheters, medical catheters in foreign developed countries are made well, but are expensive, and development of high-end high-precision medical catheters replaces import, so that the medical catheters have great significance and economic benefit for improving medical level and facilities in China. In addition to mechanical properties, medical catheters are required to be biocompatible, and therefore have certain requirements on materials.
Polytetrafluoroethylene (PTFE) is a thermoplastic engineering plastic, and PTFE has been used in the medical field because of its non-tackiness, heat resistance, hydrophobicity, and the like. The tube product is commonly used for various catheters of endoscopes and interventional medicine. However, the existing single-cavity catheter has the main defects of single function, and operations such as hemostasis, drainage, transfusion and the like are performed simultaneously when the operation is performed, and a plurality of tubes are needed simultaneously, so that the consumable materials are consumed, the operation space is increased, and meanwhile, the pain of patients can be increased. Therefore, it is of great importance to develop a PTFE multilumen tubing with multiple functional lumens that reduces the operating space.
Disclosure of Invention
The invention aims to solve the technical problems of providing a medical polytetrafluoroethylene eight-cavity tube and a preparation method thereof, aiming at the defects of the prior art, the medical polytetrafluoroethylene eight-cavity tube and the preparation method thereof have the advantages that a tube body prepared by the medical polytetrafluoroethylene eight-cavity tube comprises eight cavities, the eight cavities comprise main cavities, secondary cavities and auxiliary cavities, the cavities are not communicated with each other along the axial direction, the size of the cavities can meet various functions, such as drainage, ventilation, hemostasis, local anesthesia, radiography and the like, can simultaneously perform operations such as hemostasis, drainage, transfusion and the like, and has the advantages of small damage, small occupied space, pain reduction of patients and the like.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
the utility model provides a medical polytetrafluoroethylene eight-cavity tube, includes the body, the body has eight chambeies, and eight chambeies contain 1 main chambeies, 1 secondary chambeies and 6 auxiliary chambeies, and eight chambeies extend and each other do not UNICOM along body axial, the diameter of chambeies is 0.35-1.95mm.
As a further improved technical scheme of the invention, the cross section of the cavity is circular.
In order to achieve the technical purpose, the invention adopts another technical scheme that:
a preparation method of a medical polytetrafluoroethylene eight-cavity tube comprises the following steps:
step 1, mixing: placing the PTFE dispersion resin after sieving into a dry and clean charging basket, adding extrusion-assisting oil, uniformly mixing, and curing for more than 12 hours at 25-30 ℃;
step 2, preforming: after curing, the mixture of PTFE dispersion resin and extrusion assisting oil is preformed by using a cylinder barrel with the outer diameter of 30mm-100mm, and pressure is applied to obtain a cylindrical blank;
step 3, paste extrusion: putting the blank obtained in the step 2 into a material cavity of an extruder, and performing paste extrusion to obtain a prefabricated pipe;
step 4, drying and sintering: drying the prefabricated pipe at 100 ℃; the dried prefabricated pipe is put into a sintering furnace for high-temperature sintering, wherein the sintering temperature is 380-550 ℃ and the sintering time is 20-40 seconds;
step 5, cooling: and naturally cooling at room temperature after sintering to obtain the PTFE eight-cavity tube.
As a further improved technical scheme of the present invention, the compression ratio of the PTFE dispersion resin in the step 1 is 1600:1, standard relative density of 2.14-2.19, D 50 500+ -200 μm, apparent density of 0.450+ -0.10 g/cm 3 。
As a further improved technical scheme of the invention, the extrusion assisting oil in the step 1 is isoparaffin solvent oil.
As a further improved technical scheme of the invention, the mass ratio of the PTFE dispersion resin to the extrusion assisting oil in the step 1 is 85:15-75:25.
as a further improved technical scheme of the invention, the preformed forming pressure in the step 2 is 3MPa, the pressing speed is 50mm/min, the pressure is maintained for 5-10min, and the obtained cylindrical blank body is extruded by paste immediately or put into a sleeve for preservation.
As a further improved technical scheme of the invention, the extruder adopted in the paste extrusion in the step 3 is a vertical extruder, the extruder is connected with a multi-cavity die, a plunger push head of the extruder slowly pushes down a blank in a material cavity, and finally the blank is extruded through an outlet of the multi-cavity die connected to the extruder to obtain a prefabricated pipe fitting; the multi-cavity die comprises a multi-cavity core rod, wherein the multi-cavity core rod comprises a threaded area, a conical area and eight core rods which are sequentially connected, the total height of the multi-cavity core rod is 40-50mm, the length of the core rod is 10-20mm, and the multi-cavity core rod is made of metal copper or stainless steel.
As a further improved technical scheme of the invention, the sintering furnace in the step 4 is a vertical tube type sintering furnace, the sintering furnace is positioned below the extruder, the total length is 8m, the furnace wall of the vertical tube type sintering furnace adopts a phi 100mm stainless steel tube, the sintering furnace comprises a drying section, a sintering section and a cooling section, and the top of the sintering furnace is provided with an exhaust pipe.
The beneficial effects of the invention are as follows:
1. the invention provides a preparation method of a medical polytetrafluoroethylene eight-cavity tube, which has the advantages of simple process, high efficiency, suitability for large-scale production, high stability of the tube and high yield of the product.
2. The polytetrafluoroethylene eight-cavity tube adopting the preparation method has reasonable structure, one-step extrusion molding and avoids multiple processing, and the multi-cavity tube comprises three main cavities, namely a main cavity, a secondary cavity and an auxiliary cavity, wherein the cavities are not communicated with each other along the axial direction, the wall thickness is uniform, the size of the cavities can meet various functions, and the multi-cavity tube comprises the functions of drainage, ventilation, hemostasis, local anesthesia, radiography and the like, and has the advantages of small damage, small occupied space, pain reduction of patients and the like; can be used for interventional therapy, and has the advantages of small damage, safety, easy implementation, accurate positioning, less side effects and complications, and the like.
3. The polytetrafluoroethylene eight-cavity tube prepared by the invention has good biocompatibility and mechanical property, and PTFE tubes with different pressure resistance and flexibility can be obtained through process parameter adjustment.
Drawings
FIG. 1 is a flow chart of a preparation process of the polytetrafluoroethylene eight-cavity tube;
FIG. 2 is a schematic diagram of the assembly of a paste extruder head involved in the process of preparing polytetrafluoroethylene eight-lumen tube of the present invention;
FIG. 3 is a radial cross-sectional view of a multi-cavity mandrel of the present invention;
FIG. 4 is an axial schematic view of a multi-cavity mandrel of the present invention;
FIG. 5 is a cross-sectional view A-A of FIG. 4;
FIG. 6 is a schematic perspective view of an eight-lumen polytetrafluoroethylene tube of the present invention.
Icon: 101. plunger pushing head; 102. a cylinder; 103. an inner mold connecting rod; 104. a die fixing block; 105. a material cavity; 106. a multi-cavity mandrel; 1061. a threaded region; 1062. a conical region; 1063. a core rod; 107. an outer mold; 108. a flange gland; 109. a bolt; 110. a cutting sleeve; 111. a core bar transition assembly; 201. a tube body; 2011. and a cavity channel.
Detailed Description
The present invention is described in detail below with reference to examples, but the present invention is not limited to these examples.
In the description of the present invention, it should be noted that, if the terms "upper", "lower", "inner", "outer", etc. indicate orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the inventive product is conventionally put in use, it is merely for convenience of describing the present invention and simplifying the description, and it does not indicate or imply that the apparatus or element to be referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as limiting the present invention.
Example 1:
the embodiment provides a medical polytetrafluoroethylene eight-cavity tube, as shown in fig. 6, including a tube body 201, the tube body 201 has eight cavity channels 2011, and eight cavity channels 2011 contain 1 main cavity channel, 1 secondary cavity channel and 6 auxiliary cavity channels, and eight cavity channels 2011 extend along the tube body 201 axial and are not mutually communicated, and the diameter of cavity channels 2011 is 0.35-1.95mm. The cross section of the cavity 2011 is circular.
The embodiment also provides a preparation method of the medical polytetrafluoroethylene eight-lumen tube, as shown in fig. 1, comprising the following steps:
step 1, mixing: and (3) placing the PTFE dispersion resin after sieving into a dry and clean charging basket, adding extrusion-assisting oil, uniformly mixing, and curing for more than 12 hours at 25 ℃.
Wherein the compression ratio of the PTFE dispersion resin is 1600:1, standard relative density of 2.14, D 50 500 μm and an apparent density of 0.450g/cm 3 . The extrusion aid oil is isoparaffin solvent oil. The mass ratio of the PTFE dispersion resin to the extrusion assisting oil is 85:15.
step 2, preforming: after curing, the mixture of PTFE dispersion resin and extrusion aid was preformed using a cylinder having an outer diameter of 30mm, and a cylindrical green body was obtained by applying pressure.
Wherein the preformed molding pressure is 3MPa, the pressing speed is 50mm/min, and the pressure is maintained for 5min. The obtained cylindrical green body should be immediately extruded with paste or put into a sleeve for preservation, so as to prevent the introduction of impurities or stress damage and protect the solvent oil from being volatilized rapidly and largely.
Step 3, paste extrusion: preparing before extrusion, checking the extruder, and cleaning the multi-cavity die and the material cavity 105; setting the temperature of each sintering section, each material cavity and each die; filling the material cavity 105 with a preform; confirming the exhaust state, installing a multi-cavity die, and performing centering adjustment, wherein the multi-cavity die is not suitable for overtightening; paste extrusion is carried out to obtain the prefabricated pipe.
The extruder used in the paste extrusion in the step 3 is a vertical extruder, the extruder is connected with a multi-cavity die, the plunger pushing head 101 of the extruder slowly pushes down the blank in the material cavity 105, and finally the blank is extruded through the outlet hole of the multi-cavity die connected to the extruder, so as to obtain the prefabricated pipe fitting.
Step 4, drying and sintering: before reaching the sintering section, the auxiliary agent oil is completely volatilized, so that the prefabricated pipe is dried at the drying temperature of 100 ℃; and then, the dried prefabricated pipe is put into a sintering furnace for high-temperature sintering, the sintering temperature is 380 ℃, the time is 40 seconds, and the PTFE eight-cavity pipe is put out of the sintering furnace and is in a transparent state.
The sintering furnace is a vertical tube type sintering furnace, is directly arranged below an extruder, has the total length of 8m, is manufactured by using a stainless steel tube with the diameter of 100mm, and is divided into a drying section, a sintering section and a cooling section, and the top of the sintering furnace is provided with an exhaust pipe for removing auxiliary extrusion oil and other harmful gases.
Step 5, cooling: in order to ensure the strength of the PTFE pipe, the PTFE pipe is naturally cooled at room temperature after sintering is completed, and the PTFE eight-cavity pipe is obtained.
Example 2:
the embodiment provides a medical polytetrafluoroethylene eight-cavity tube, which comprises a tube body 201, wherein the tube body is provided with eight cavity channels 2011, the eight cavity channels 2011 comprise 1 main cavity channel, 1 secondary cavity channel and 6 auxiliary cavity channels, the eight cavity channels 2011 extend along the axial direction of the tube body 201 and are not communicated with each other, and the diameter of the cavity channels 2011 is 0.35-1.95mm. The cross section of the cavity 2011 is circular.
The embodiment also provides a preparation method of the medical polytetrafluoroethylene eight-cavity tube, which comprises the following steps:
step 1, mixing: and (3) placing the PTFE dispersion resin after sieving into a dry and clean charging basket, adding extrusion-assisting oil, uniformly mixing, and curing for more than 12 hours at the temperature of 28 ℃.
Wherein the compression ratio of the PTFE dispersion resin is 1600:1, standard relative density of 2.16, D 50 300 μm and an apparent density of 0.350g/cm 3 . The extrusion aid oil is isoparaffin solvent oil. The mass ratio of the PTFE dispersion resin to the extrusion assisting oil is 80:20.
step 2, preforming: after curing, the mixture of PTFE dispersion resin and extrusion aid was preformed using a cylinder having an outer diameter of 60mm, and a cylindrical green body was obtained by applying pressure.
Wherein the preformed molding pressure is 3MPa, the pressing speed is 50mm/min, and the pressure is maintained for 7min. The obtained cylindrical green body should be immediately extruded with paste or put into a sleeve for preservation, so as to prevent the introduction of impurities or stress damage and protect the solvent oil from being volatilized rapidly and largely.
Step 3, paste extrusion: preparing before extrusion, checking the extruder, and cleaning the multi-cavity die and the material cavity 105; setting the temperature of each sintering section, each material cavity and each die; filling the material cavity 105 with a preform; confirming the exhaust state, installing a multi-cavity die, and performing centering adjustment, wherein the multi-cavity die is not suitable for overtightening; paste extrusion is carried out to obtain the prefabricated pipe.
The extruder adopted in the paste extrusion in the step 3 is a vertical extruder, the extruder is connected with a multi-cavity die, a plunger pushing head of the extruder slowly pushes down a blank in a material cavity, and finally the blank is extruded through an outlet of the multi-cavity die connected to the extruder, so that a prefabricated pipe fitting is obtained.
Step 4, drying and sintering: before reaching the sintering section, the auxiliary agent oil is completely volatilized, so that the prefabricated pipe is dried at the drying temperature of 100 ℃; and then, the dried prefabricated pipe is put into a sintering furnace for high-temperature sintering, the sintering temperature is 450 ℃, the time is 30 seconds, and the PTFE eight-cavity pipe is put out of the sintering furnace and is in a transparent state.
The sintering furnace is a vertical tube type sintering furnace, is directly arranged below an extruder, has the total length of 8m, is manufactured by using a stainless steel tube with the diameter of 100mm, and is divided into a drying section, a sintering section and a cooling section, and the top of the sintering furnace is provided with an exhaust pipe for removing auxiliary extrusion oil and other harmful gases.
Step 5, cooling: in order to ensure the strength of the PTFE pipe, the PTFE pipe is naturally cooled at room temperature after sintering is completed, and the PTFE eight-cavity pipe is obtained.
Example 3:
the embodiment provides a medical polytetrafluoroethylene eight-cavity tube, which comprises a tube body 201, wherein the tube body 201 is provided with eight cavity channels 2011, the eight cavity channels 2011 comprise 1 main cavity channel, 1 secondary cavity channel and 6 auxiliary cavity channels, the eight cavity channels 2011 extend along the axial direction of the tube body 201 and are not communicated with each other, and the diameter of the cavity channels 2011 is 0.35-1.95mm. The cross section of the cavity 2011 is circular.
The embodiment also provides a preparation method of the medical polytetrafluoroethylene eight-cavity tube, which comprises the following steps:
step 1, mixing: and (3) placing the PTFE dispersion resin after sieving into a dry and clean charging basket, adding extrusion-assisting oil, uniformly mixing, and curing for more than 12 hours at 30 ℃.
Wherein the compression ratio of the PTFE dispersion resin is 1600:1, standard relative density of 2.19, D 50 700 μm and an apparent density of 0.550g/cm 3 . The extrusion aid oil is isoparaffin solvent oil. The mass ratio of the PTFE dispersion resin to the extrusion assisting oil is 75:25.
step 2, preforming: after curing, the mixture of PTFE dispersion resin and extrusion aid was preformed using a cylinder having an outer diameter of 100mm, and a cylindrical green body was obtained by applying pressure.
Wherein the preformed molding pressure is 3MPa, the pressing speed is 50mm/min, and the pressure is maintained for 10min. The obtained cylindrical green body should be immediately extruded with paste or put into a sleeve for preservation, so as to prevent the introduction of impurities or stress damage and protect the solvent oil from being volatilized rapidly and largely.
Step 3, paste extrusion: preparing before extrusion, checking the extruder, and cleaning the multi-cavity die and the material cavity 105; setting the temperature of each sintering section, each material cavity and each die; filling the material cavity 105 with a preform; confirming the exhaust state, installing a multi-cavity die, and performing centering adjustment, wherein the multi-cavity die is not suitable for overtightening; paste extrusion is carried out to obtain the prefabricated pipe.
The extruder adopted in the paste extrusion in the step 3 is a vertical extruder, the extruder is connected with a multi-cavity die, a plunger pushing head of the extruder slowly pushes down a blank in a material cavity, and finally the blank is extruded through an outlet of the multi-cavity die connected to the extruder, so that a prefabricated pipe fitting is obtained.
Step 4, drying and sintering: before reaching the sintering section, the auxiliary agent oil is completely volatilized, so that the prefabricated pipe is dried at the drying temperature of 100 ℃; and then, the dried prefabricated pipe is put into a sintering furnace for high-temperature sintering, the sintering temperature is 550 ℃, the time is 20 seconds, and the PTFE eight-cavity pipe is put out of the sintering furnace and is in a transparent state.
The sintering furnace is a vertical tube type sintering furnace, is directly arranged below an extruder, has the total length of 8m, is manufactured by using a stainless steel tube with the diameter of 100mm, and is divided into a drying section, a sintering section and a cooling section, and the top of the sintering furnace is provided with an exhaust pipe for removing auxiliary extrusion oil and other harmful gases.
Step 5, cooling: in order to ensure the strength of the PTFE pipe, the PTFE pipe is naturally cooled at room temperature after sintering is completed, and the PTFE eight-cavity pipe is obtained.
The extruder head assembly of the extruder used in the above embodiment is shown in fig. 2, the extruder mainly comprises a plunger push head 101, a cylinder 102, an inner die connecting rod 103 and a material cavity 105, and the multi-cavity die comprises a die fixing block 104, a multi-cavity core rod 106, an outer die 107, a flange gland 108, bolts 109, a clamping sleeve 110 and a core rod transition assembly 111; the multi-cavity core rod 106 is arranged at the lower part of the core rod transition assembly 111, the core rod transition assembly 111 is arranged at the lower part of the internal mold connecting rod 103 through threaded connection, and the connection is screwed from left to right during installation; the outer die 107 is mounted at the bottom of the multi-cavity core rod 106, the core rod 1063 is positioned in a hole of the outer die 107, the outer die 107 and the die fixing block 104 are pressed by four screws on the flange gland 108, and the bolts 109 penetrate through the clamping sleeve 110 from bottom to top and are screwed with the cylinder body 102 from left to right, so that the die fixing block 104 is connected with the cylinder body 102.
As shown in fig. 3, 4 and 5, the multi-cavity core rod 106 comprises a threaded area 1061, a conical area 1062 and eight core rods 1063 which are sequentially connected, the total height of the multi-cavity core rod 106 is 40-50mm, the length of the core rod 1063 is 10-20mm, and the multi-cavity core rod 106 is made of metal copper or stainless steel.
FIG. 6 is a schematic view of a polytetrafluoroethylene eight-lumen tube provided by the invention, comprising eight functional lumens which are sequentially and uniformly arranged along the radial direction; the eight-lumen tube has at least the following advantages:
the multi-cavity tube provided by the invention is designed into eight-cavity functional cavities, sequentially and uniformly arranged along the radial direction, axially parallel and not communicated with each other, the size of the cavities can meet various functions, including drainage, ventilation, hemostasis, local anesthesia, radiography and the like, and can simultaneously perform operations such as hemostasis, drainage, transfusion and the like, and the multi-cavity tube has the advantages of small damage, small occupied space, pain reduction of patients and the like; the tube body has smaller diameter, smooth inner and outer parts and low friction coefficient, is used for anorectal department, and effectively relieves the pain of patients.
Placing the preform into a material cavity 105, and mounting a die fixing block 104 at the bottom of the material cavity 105 before pushing and extruding; a multi-cavity mandrel 106, a flange gland 108, an outer die 107, etc. are installed. After the installation, starting an extrusion driving device, wherein the extrusion driving device drives a plunger pushing head 101 to downwards drive a blank in a contact material cavity 105 to push at a set speed; the multi-lumen tube product shown in fig. 3 can be obtained by extruding a preform tube through the exit orifice of the multi-lumen die (i.e., the space between the cylindrical orifice of the outer die 107 and the core rod 1063), and then drying, sintering, cooling, etc.
The present invention is not limited to the above embodiments, but is capable of other embodiments and modifications, and other embodiments, as will be apparent to those skilled in the art, without departing from the scope of the invention.
Claims (10)
1. The medical polytetrafluoroethylene eight-cavity tube is characterized by comprising a tube body, wherein the tube body is provided with eight cavity channels, each cavity channel comprises 1 main cavity channel, 1 secondary cavity channel and 6 auxiliary cavity channels, the eight cavity channels extend along the axial direction of the tube body and are not communicated with each other, and the diameter of each cavity channel is 0.35-1.95mm.
2. The medical polytetrafluoroethylene eight lumen according to claim 1 wherein the lumen is circular in cross-section.
3. A method of preparing a medical polytetrafluoroethylene eight-lumen tube according to claim 1, comprising:
step 1, mixing: placing the PTFE dispersion resin after sieving into a dry and clean charging basket, adding extrusion-assisting oil, uniformly mixing, and curing for more than 12 hours at 25-30 ℃;
step 2, preforming: after curing, the mixture of PTFE dispersion resin and extrusion assisting oil is preformed by using a cylinder barrel with the outer diameter of 30mm-100mm, and pressure is applied to obtain a cylindrical blank;
step 3, paste extrusion: putting the blank obtained in the step 2 into a material cavity of an extruder, and performing paste extrusion to obtain a prefabricated pipe;
step 4, drying and sintering: drying the prefabricated pipe at 100 ℃; the dried prefabricated pipe is put into a sintering furnace for high-temperature sintering, wherein the sintering temperature is 380-550 ℃ and the sintering time is 20-40 seconds;
step 5, cooling: and naturally cooling at room temperature after sintering to obtain the PTFE eight-cavity tube.
4. The method for preparing a medical polytetrafluoroethylene eight-lumen tube according to claim 3, wherein the compression ratio of the PTFE dispersion resin in the step 1 is 1600:1, standard relative density of 2.14-2.19, D 50 500+ -200 μm, apparent density of 0.450+ -0.10 g/cm 3 。
5. The method for preparing a medical polytetrafluoroethylene eight-lumen tube according to claim 3, wherein the extrusion assisting oil in the step 1 is isoparaffinic solvent oil.
6. The method for preparing a medical polytetrafluoroethylene eight-lumen tube according to claim 3, wherein the mass ratio of the PTFE dispersion resin to the extrusion assisting oil in the step 1 is 85:15-75:25.
7. the method for preparing a medical polytetrafluoroethylene eight-lumen tube according to claim 3, wherein the preformed molding pressure in the step 2 is 3MPa, the pressing speed is 50mm/min, the pressure is maintained for 5-10min, and the obtained cylindrical blank body is extruded with paste immediately or put into a sleeve for preservation.
8. The method for preparing a medical polytetrafluoroethylene eight-cavity tube according to claim 3, wherein the extruder used for paste extrusion in the step 3 is a vertical extruder, the extruder is connected with a multi-cavity die, a plunger pushing head of the extruder slowly pushes down a blank in a material cavity, and finally the blank is extruded through an outlet hole of the multi-cavity die connected to the extruder to obtain a prefabricated tube; the multi-cavity die comprises a multi-cavity core rod, wherein the multi-cavity core rod comprises a threaded area, a conical area and eight core rods which are sequentially connected, the total height of the multi-cavity core rod is 40-50mm, the length of the core rod is 10-20mm, and the multi-cavity core rod is made of metal copper or stainless steel.
9. The method for preparing the medical polytetrafluoroethylene eight-cavity tube according to claim 3, wherein the sintering furnace in the step 4 is a vertical tube type sintering furnace, the sintering furnace is positioned below an extruder, the total length is 8m, a stainless steel tube with the diameter of phi of 100mm is adopted as the furnace wall of the vertical tube type sintering furnace, the sintering furnace comprises a drying section, a sintering section and a cooling section, and an exhaust pipe is arranged at the top of the sintering furnace.
10. A medical polytetrafluoroethylene octalumen prepared according to the method of any one of claims 3-9.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310405599.6A CN116617532A (en) | 2023-04-17 | 2023-04-17 | Medical polytetrafluoroethylene eight-lumen tube and preparation method thereof |
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| CN202310405599.6A CN116617532A (en) | 2023-04-17 | 2023-04-17 | Medical polytetrafluoroethylene eight-lumen tube and preparation method thereof |
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|---|---|---|---|---|
| CN203139357U (en) * | 2012-12-31 | 2013-08-21 | 山东省立医院 | Gynecological triple-bag multi-cavity tube |
| CN109171866A (en) * | 2018-10-23 | 2019-01-11 | 王浩 | A kind of pharyngeal cavity pipe |
| CN112549485A (en) * | 2020-11-18 | 2021-03-26 | 山东东岳高分子材料有限公司 | Polytetrafluoroethylene multi-cavity extrusion pipe and processing method thereof |
| CN113786227A (en) * | 2021-09-29 | 2021-12-14 | 南微医学科技股份有限公司 | Multi-cavity tube and nipple sphincter incision knife |
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2023
- 2023-04-17 CN CN202310405599.6A patent/CN116617532A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203139357U (en) * | 2012-12-31 | 2013-08-21 | 山东省立医院 | Gynecological triple-bag multi-cavity tube |
| CN109171866A (en) * | 2018-10-23 | 2019-01-11 | 王浩 | A kind of pharyngeal cavity pipe |
| CN112549485A (en) * | 2020-11-18 | 2021-03-26 | 山东东岳高分子材料有限公司 | Polytetrafluoroethylene multi-cavity extrusion pipe and processing method thereof |
| CN113786227A (en) * | 2021-09-29 | 2021-12-14 | 南微医学科技股份有限公司 | Multi-cavity tube and nipple sphincter incision knife |
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Application publication date: 20230822 |