CN116612862A - Management system based on WSI full-view digital slice - Google Patents
Management system based on WSI full-view digital slice Download PDFInfo
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- CN116612862A CN116612862A CN202310502266.5A CN202310502266A CN116612862A CN 116612862 A CN116612862 A CN 116612862A CN 202310502266 A CN202310502266 A CN 202310502266A CN 116612862 A CN116612862 A CN 116612862A
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- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
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- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
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- G—PHYSICS
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- G16H30/00—ICT specially adapted for the handling or processing of medical images
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- G—PHYSICS
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- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
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Abstract
The invention relates to the technical field of medical image management, in particular to a WSI (wireless sensor infrastructure) full-view digital slice-based management system, which comprises a slice image acquisition system, an image storage system and a pathology information system, wherein the slice image acquisition system is used for manufacturing a pathology wave plate into a full-view digital slice image, the image storage system is used for storing the full-view digital slice image in a tile image storage mode, and the pathology information system is used for sending retrieval and transmission service requests to the image storage system. The invention solves the limitations of the traditional pathological slide in time and space.
Description
Technical Field
The invention relates to the technical field of medical image management, in particular to a management system based on WSI full-view digital slices.
Background
The traditional pathological section is prepared by taking pathological tissues with a certain size, and the pathological section is prepared by a pathological histology method, and the pathological section is further checked by a microscope, but the defects of fragile glass slides, high storage cost, inconvenience in mailing and transportation, consultation at a foreign hospital, and returning of the glass slides are overcome. Therefore, a digital slicing concept is introduced, the whole glass slide is scanned in an omnibearing and rapid way by utilizing a glass slide scanning system, a high-resolution digital image is acquired, and then the acquired image is subjected to high-precision multi-view seamless splicing and processing by utilizing a computer, so that a high-quality pathological glass slide image is obtained, and is filed in an image storage system to be convenient to retrieve and transmit.
The traditional materialized glass slide is changed into a new generation digital pathology glass slide image, a doctor is helped to get rid of the constraint of a traditional microscope, and a reader can completely and conveniently browse any slice in a storage system, so that the doctor can communicate on medical diagnosis at any time and any place through the Internet, and global online real-time remote consultation or offline remote consultation is realized. In addition, the digitized slices are convenient to store, and the loss caused by continuous tissue slice loss in the teaching or medical research process is avoided. The full-field digital slicing technology realizes epoch-making transformation on the pathological diagnosis technology.
The existing medical browsing image system has the defects of overlarge image system files and large occupied space in storage and remote browsing interaction, and cannot provide powerful guarantee for field operation and teaching.
Disclosure of Invention
The invention provides a WSI-based full-view digital slice management system, which solves the problems that a traditional slide is fragile in material and easy to damage in the teaching or medical research process; the sliced tissue is discolored and can not be stored for a long time, so that the resource waste is caused.
In order to achieve the purpose of the invention, the technical scheme adopted is as follows: a management system based on WSI full-view digital slicing comprises a slicing image acquisition system, an image storage system and a pathology information system, wherein the slicing image acquisition system is used for manufacturing a pathology wave plate into a full-view digital slicing image, the image storage system is used for storing the full-view digital slicing image in a tile image storage mode, and the pathology information system is used for sending retrieval and transmission service requests to the image storage system.
As an optimization scheme of the invention, the tile image storage mode specifically comprises the following steps:
s1-1, dividing a full-view digital slice image into n rectangular tile images, recording position information of each rectangular tile image in the full-view digital slice image, storing each rectangular tile image in a stripe mode, wherein each tile image is independent, independent compression mode and independent data, and the tile image data are not greatly related, so that the tile image data contained in a certain area in a certain large image can be calculated, and only the tile images are loaded;
s1-2, storing the digital slices by using an image pyramid structure, wherein different layers of the pyramid correspond to different resolutions, and the number of frames corresponding to the different resolutions is also different; the bottommost layer of the pyramid model corresponds to the image with the highest resolution and is called level 0, the middle layer of the pyramid model is a thumbnail of the bottommost layer image, namely, the images with other resolutions are respectively called level 1 to level n from bottom to top, and a digital slice file group is constructed and stored in an image storage system. So that the user has an image with corresponding resolution when browsing the full-view digitized slice image with a certain zoom factor.
S1-3, typically between the wide high resolution of each level image is one-half or 4 (assuming a 1000x1000 resolution image, the image resolution of the layer smaller than it is one-half 500x500-2 or one-half 250x250-4, and the smaller layer is one-half or one-fourth smaller). Since we can support arbitrary scaling when browsing the slice, but it is impossible to have an image with a corresponding resolution for each scaling factor, when browsing the image, the browsing software loads an image with a resolution suitable for the current factor according to a threshold according to the current scaling factor of the current user, and then scales to a corresponding real factor according to the loaded image.
As an optimization scheme of the invention, the processing steps of the slice image acquisition system are as follows:
s2-1, receiving a sample to obtain a pathological wave plate;
s2-2, digitally scanning the pathological wave plate: the digital microscope is used for scanning, collecting and imaging pathological slide, scanning and moving according to X, Y axis direction during scanning, automatically focusing in Z axis direction, collecting high-resolution digital image, and performing seamless splicing treatment to obtain full-field digital slice.
As an optimization scheme of the invention, the image storage system adopts a NAS or SAN storage mode for storage.
As an optimization scheme of the invention, the image storage system is called and browsed through the WEB terminal.
As an optimization scheme of the invention, the image storage system executes the system call of the user request, the execution result is returned to the pathology information system, the pathology information system sends out the image transmission service request, and the image storage system transmits the image to the user program by utilizing the FTP or HTTP protocol.
As an optimization scheme of the invention, a browsing client based on a user program is constructed, and the browsing client comprises patient case classification, a daily list of medical service requests, a viewing report and image information and a result observed in each case in a tracing way.
As an optimization scheme of the invention, the electronic medical record retrieves pathological images through the image storage system, and retrieves PDF pathological reports and JPEG pathological pictures through the URL interface.
The invention has the positive effects that: 1) The invention gets rid of the limitation of the traditional microscope, can read the film easily through a computer screen, and can enlarge the image at will, thereby facilitating the observation of the detail of the lesions; the images are stored in a computer in a large scale, quantitative analysis is carried out on the images, diagnosis and scientific research are facilitated, and timely and rapid remote consultation is supported.
2) The invention stores the digital slice image of the full field of view in a digital pathological slice library established in an image storage system, can construct a pathological information system and a diagnosis browsing client for the digital pathological slice, and transmits the acquired digital image and patient medical record information to a pathological image management platform through a hospital information integration platform, so that medical staff, specialists and students can browse the digital pathological slice library to carry out remote consultation, remote diagnosis, remote teaching and the like;
3) The invention prepares the traditional pathological slide into the full-view digital slice image. The requirements of pathological diagnosis on quality and performance of images are high, and the requirements of rapid zooming, translation and the like of image display are required to be met.
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The invention will be described in further detail with reference to the drawings and the detailed description.
FIG. 1 is a schematic flow chart of the present invention;
fig. 2 is a schematic diagram of the present invention.
Detailed Description
As shown in fig. 1, the invention discloses a management system based on WSI full-view digital slicing, which comprises a slicing image acquisition system, an image storage system and a pathology information system, wherein the slicing image acquisition system is used for manufacturing a pathology wave plate into a full-view digital slicing image, the image storage system is used for storing the full-view digital slicing image in a tile image storage mode, and the pathology information system is used for sending retrieval and transmission service requests to the image storage system. The image storage system can archive and store the digitized slice images.
Because the whole full-field digital slice image occupies too much space, a computer cannot normally load the whole full-field digital slice image into a memory, but directly stores the whole full-field digital slice image in a strip image data storage mode, and cannot directly load a preview image.
The tile image storage mode specifically comprises the following steps:
s1-1, dividing a full-view digital slice image into n rectangular tile images, recording position information of each rectangular tile image in the full-view digital slice image, and storing each rectangular tile image in a strip mode;
and dividing the full-view digital slice image into rectangular small images, and recording the information of the positions of each tile image belonging to the original large image. Each tile map is stored in the form of a strip as a common image, each tile map is independent, independent compression mode and independent data, and the image data of each tile map is not greatly related, so that the tile map data contained in a certain area in a certain large map can be calculated, and only the tile maps are loaded.
The tile storage mode only solves the problem of image loading when browsing large images, so that a user only loads image data of a part of image areas browsed when browsing images, the image data is processed under the maximum resolution of the images, and only the browsing requirement when translating the images can be met (moving to different image positions, loading the part of tile images at the image positions).
S1-2, storing by using an image pyramid structure, wherein different layers of the pyramid correspond to different resolutions, and the number of frames corresponding to the different resolutions is also different; the bottommost layer of the pyramid model corresponds to the image with the highest resolution and is called level 0, the middle layer of the pyramid model is a thumbnail of the bottommost layer image, namely, the images with other resolutions are respectively called level 1 to level n from bottom to top, and a digital slice file group is constructed and stored in an image storage system. The user can browse the full-view digital slice image with a certain zoom multiple and have the image with the corresponding resolution, namely the user can perform zoom operation when browsing the image.
S1-3, the width and the high resolution of each level image are generally one-half or one-half of 2, and when browsing the images, browsing software loads the images with the resolution suitable for the current times according to the current scaling times of the current users and loads the images with the resolution suitable for the current times according to a threshold value, and then scales to corresponding real times according to the loaded images.
Wherein: after the sample is received, a pathological slide is obtained through a slide preparation process, and then the acquisition of the digital section is completed through a slide scanning system. When a user browses images under different zoom factors, the image pyramid is used for realizing that the images with proper resolution are all available, and the width and the high resolution of each level of images are generally one half or one quarter. A full field of view digitized slice containing multiple images of the same pattern of different resolutions from large to small is ultimately stored in the image storage system in the form of a digital slice file.
The processing steps of the slice image acquisition system are as follows:
s2-1, receiving a sample to obtain a pathological wave plate;
s2-2, digitally scanning the pathological wave plate: the digital microscope is used for scanning, collecting and imaging pathological slide, scanning and moving according to X, Y axis direction during scanning, automatically focusing in Z axis direction, collecting high-resolution digital image, and performing seamless splicing treatment to obtain full-field digital slice. The slide scanning system is used for digitally scanning pathological slides, wherein a digital pathological section system is adopted, and is different from a traditional microscope and mainly comprises a digital section scanning device and data processing software. The digital section enables the pathological wave plate to get rid of the limit of the traditional microscope, and the pathological wave plate can be easily read through a computer screen, and the image can be arbitrarily enlarged, so that pathological details can be conveniently observed; the images are stored in a computer in a large scale, quantitative analysis is carried out on the images, diagnosis and scientific research are facilitated, and timely and rapid remote consultation is supported.
The image storage system adopts NAS or SAN storage mode for storage. The image archiving request service is sent to store the pathological slide images in the image storage system, so that doctors in different hospital areas or students in medical schools are supported to synchronously browse the full-view digital slices and mark the pathological change positions, the working place and working time of the pathological doctors are not limited any more, and the pathological diagnosis resources can be effectively and planarly played and utilized.
And calling and browsing the image storage system through the WEB terminal. The report and the image can be browsed through the WEB terminal.
The image storage system executes the system call of the user request, returns the execution result to the pathology information system, sends out an image transmission service request, and transmits the image to the user program by using the FTP or HTTP protocol. The image storage system is tightly integrated with the HIS, EMR healthcare workstation, PACS, and hospital integrated platform. Support includes first consultation, supplementary report, audit, consultation, etc., send image call request to image storage system;
and (3) utilizing a corresponding digital pathological section browsing system to conduct browsing and analysis processing of any scale enlargement or reduction and any direction movement on a series of visual data. A browsing client based on a user program is constructed, wherein the browsing client comprises patient case classification, a daily list of medical service requests, a viewing report and image information and a result observed in each case in a tracing way. The client is browsed to enable a doctor to log in the system through the diagnosis browser to conduct patient case classification, check the diagnosis cases such as the current-day case, the examination case, the consultation case, the follow-up case and the like, also can check the daily list of the organization number, the department number and the medical service request, order the list according to preference, check information such as reports, images and the like, and simultaneously the system also supports the tracing of the observed results of the pathologist in each case and part.
The electronic medical record retrieves pathological images through the image storage system, and retrieves PDF pathological reports and JPEG pathological pictures through the URL interface.
As shown in fig. 2, an image storage system and a diagnosis browsing client are built, the collected full-field digital slices are transmitted to the image storage system for storage, and the pathology information system can review and diagnose the digital slices in the storage system. The pathologist classifies the patient cases through the function of the pathological information system, checks the diagnosis cases such as the current-day case, the examination case, the consultation case, the follow-up case and the like, can also check the daily list of the organization number, the department number and the medical service request, sorts the list according to preference, and supports the tracing of the observed results of the pathologist in each case and part.
The pathology information system is fully integrated with systems such as hospital HIS (hospital information system), PACS (image archiving and communication system), EMR (computerized medical record system) and the like, so that information resource sharing is realized, technical workflow is optimized, production efficiency is improved, and pathology report sending time is shortened. The system and the HIS transmit the examination application, report and charging information through the intermediate table, and retrieve other examination report information of the patient through the Web Service.
While the foregoing is directed to embodiments of the present invention, other and further details of the invention may be had by the present invention, it should be understood that the foregoing description is merely illustrative of the present invention and that no limitations are intended to the scope of the invention, except insofar as modifications, equivalents, improvements or modifications are within the spirit and principles of the invention.
Claims (8)
1. A management system based on WSI full-view digital slice is characterized in that: the system comprises a slice image acquisition system, an image storage system and a pathology information system, wherein the slice image acquisition system is used for manufacturing a pathology wave plate into a full-view digital slice image, the image storage system is used for storing the full-view digital slice image in a tile image storage mode, and the pathology information system is used for sending retrieval and transmission service requests to the image storage system.
2. A WSI full-field digital slice based management system according to claim 1, wherein: the tile image storage mode specifically comprises the following steps:
s1-1, dividing a full-view digital slice image into n rectangular tile images, recording position information of each rectangular tile image in the full-view digital slice image, storing each rectangular tile image in a stripe form, calculating which tile image data are contained in a certain area in a certain large image, and only loading the tile images;
s1-2, storing the digital slices by using an image pyramid structure, wherein different layers of the pyramid correspond to different resolutions, and the number of frames corresponding to the different resolutions is also different; the bottommost layer of the pyramid model corresponds to the image with the highest resolution, which is called level 0, the middle layer of the pyramid model is a thumbnail of the bottommost layer image, namely, other resolution images are respectively called level 1 to level n from bottom to top, a digital slice file group is constructed and stored in an image storage system, so that a user has the image with the corresponding resolution when browsing the full-view digital slice image with a certain zoom multiple;
s1-3, the width and the high resolution of each level image are one half or one quarter, the image with the resolution suitable for the current multiple is loaded according to a threshold value according to the current scaling multiple of the current user, and then the image is scaled to the corresponding real multiple according to the loaded image.
3. A WSI full-field digital slice based management system according to claim 2, wherein: the processing steps of the slice image acquisition system are as follows:
s2-1, receiving a sample to obtain a pathological wave plate;
s2-2, digitally scanning the pathological wave plate: the digital microscope is used for scanning, collecting and imaging pathological slide, scanning and moving according to X, Y axis direction during scanning, automatically focusing in Z axis direction, collecting high-resolution digital image, and performing seamless splicing treatment to obtain full-field digital slice.
4. A WSI full-field digital slice based management system according to claim 2, wherein: the image storage system adopts NAS or SAN storage mode for storage.
5. A WSI full-field digital slice based management system according to claim 2, wherein: and calling and browsing the image storage system through the WEB terminal.
6. A WSI full-field digital slice based management system according to claim 2, wherein: the image storage system executes the system call of the user request, returns the execution result to the pathology information system, sends out an image transmission service request, and transmits the image to the user program by using the FTP or HTTP protocol.
7. The WSI full-field digital slice-based management system of claim 6, wherein: a browsing client based on a user program is constructed, wherein the browsing client comprises patient case classification, a daily list of medical service requests, a viewing report and image information and a result observed in each case in a tracing way.
8. A WSI full-field digital slice based management system according to claim 2, wherein: the electronic medical record retrieves pathological images through the image storage system, and retrieves PDF pathological reports and JPEG pathological pictures through the URL interface.
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