CN116531644A - Accurate positioning medicine application catheter, application and treatment system thereof - Google Patents
Accurate positioning medicine application catheter, application and treatment system thereof Download PDFInfo
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- CN116531644A CN116531644A CN202310825309.3A CN202310825309A CN116531644A CN 116531644 A CN116531644 A CN 116531644A CN 202310825309 A CN202310825309 A CN 202310825309A CN 116531644 A CN116531644 A CN 116531644A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M2025/0008—Catheters; Hollow probes having visible markings on its surface, i.e. visible to the naked eye, for any purpose, e.g. insertion depth markers, rotational markers or identification of type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1064—Large intestine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1067—Anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1085—Bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1089—Urethra
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/16—Male reproductive, genital organs
- A61M2210/166—Prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/16—Male reproductive, genital organs
- A61M2210/167—Penis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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Abstract
The invention discloses a precise positioning medicine applying catheter, application and a treatment system thereof, and belongs to the technical field of medical equipment. The administration catheter comprises: the drug delivery catheter comprises a drug delivery catheter body and a positioning ring arranged on the drug delivery catheter body, wherein the drug delivery catheter body is a hollow catheter; the drug delivery catheter body is a balloon drug delivery catheter body or a balloon drug delivery catheter body; a closed space for administration and treatment is formed in the natural cavity and organs of the human body by the ball or the balloon on the administration catheter body based on the positioning ring arranged on the administration catheter body. The invention also discloses application of the drug delivery catheter in treating rectal cancer, prostatic cancer and bladder cancer and a treatment system thereof.
Description
Technical Field
The invention relates to the technical fields of cancer treatment medical equipment, medicine power, medicine application paths and the like, in particular to a precisely positioned medicine application catheter, application and a treatment system thereof.
Background
For patients with early cancer, surgical treatment is effective. However, for patients diagnosed with advanced middle-stage cancer, the most effective current treatment regimens for surgery, chemotherapy, radiation therapy, and targeted drugs only alleviate the clinical symptoms caused by cancer metastasis, and the likelihood of clinical cure remains low. Systemic treatment with chemotherapeutic agents not only brings strong side effects and responses to patients, but also has lower therapeutic efficacy against moderately sensitive cancers, such as rectal cancer, prostate cancer and bladder cancer. In the case of prostate cancer patients, androgen Deprivation Therapy (ADT) affects marital life and quality of life to varying degrees and psychological disturbances following treatment of the patient.
In addition, after the traditional oral medicine for treating cancers is damaged by gastric acid and digestive enzymes and has liver first pass effect, the original active ingredients in the medicine are greatly weakened, so that the treatment effect is greatly reduced. Increasing the dosage of oral medications produces greater side effects and physiological discomfort to the body. The traditional Chinese medicine considers that the recurrence and metastasis of the cancer are caused by unbalanced constitution and deficiency of the body constitution, and long-term and wide-range clinical data show that the traditional Chinese medicine is effective for transforming constitution and strengthening body resistance and detoxifying treatment methods. Currently, some oral medicines for treating cancers have obtained satisfactory clinical effects. However, there is a real technical need in the art for maximizing the preservation of the original active ingredients in the drug and improving the cancer therapeutic effect of the drug without the destruction of gastric acid and digestive enzymes and the first pass effect of the liver.
In addition, the traditional medicine cannot be precisely applied to the cancer focus by the traditional medicine treatment method, so that an effective target-point precise administration route and a treatment method for directly contacting the cancer focus and tissues around the focus, which are infiltrated by cancer cells, with the treatment medicine cannot be realized.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a technical scheme that the accurate positioning medicine applying catheter, application and a treatment system thereof are used for treating cancer focus, and the problems of original active ingredient loss, reduced treatment intensity and reduced treatment effect in the traditional oral medicine for treating cancer are solved through an effective target-point type medicine applying way and a direct contact type treatment method. The invention can be used for treating (without limitation) rectal cancer, prostatic cancer and bladder cancer, and has the characteristics of simple operation, higher curative effect, lower cost, easy popularization and the like.
In one aspect, the present invention provides a precisely positioned applicator catheter comprising:
the drug delivery catheter comprises a drug delivery catheter body and a positioning ring arranged on the drug delivery catheter body, wherein the drug delivery catheter body is a hollow catheter; the drug delivery catheter body is a balloon drug delivery catheter body and a balloon drug delivery catheter body; forming a closed space for administration and treatment in the natural cavity and organs of the human body through a ball or a balloon on the administration catheter body based on the positioning ring arranged on the administration catheter body;
For the ball administration catheter main body, a non-porous hollow elliptic ball or a porous hollow elliptic ball is arranged at the head end of the administration catheter main body, the long axis of the non-porous hollow elliptic ball or the porous hollow elliptic ball is coincident with the central line of the administration catheter main body, and the short axis of the non-porous hollow elliptic ball or the porous hollow elliptic ball is larger than the outer diameter of the administration catheter main body; the rear end of the ball pesticide application catheter main body is provided with a ball pesticide application catheter connector;
for a balloon applicator catheter body, providing a balloon on an outer surface of a front portion of the balloon applicator catheter body; the balloon is tightly wrapped on the outer surface of the balloon administration catheter body; the air bag is an annular air bag when inflated; leaving a small portion of the balloon applicator catheter body in front of the balloon after the balloon applicator catheter body passes through the balloon; the head end of the air bag pesticide applying catheter main body is provided with an arc-shaped cap to seal the head end of the air bag pesticide applying catheter main body; the rear part of the air sac pesticide application catheter main body is provided with a branch catheter and a valve connected with the branch catheter; a thin conduit disposed within the catheter body connects the valve to the balloon; the air bag is tightly wrapped on the outer surface of the air bag drug application catheter main body when entering the body; after the main body of the air sac dispensing catheter enters a natural cavity or an organ of a human body and reaches a set position, a rubber balloon or an injector is used for injecting gas or water into the air sac through the valve on the branch catheter and the thin catheter so as to bulge the air sac; the gas or water in the air bag is discharged out of the air bag through the valves on the fine guide pipe and the branch guide pipe; the rear end of the balloon administration catheter main body is provided with a balloon administration catheter connector.
Preferably, a length scale matched with the positioning ring is printed or added on the outer surface of the medicine application catheter main body; for a balloon administration catheter body, the zero point of the length scale is positioned at the joint of the head end of the administration catheter body and a non-porous hollow oval balloon or a porous hollow oval balloon; for balloon applicator catheter bodies, the zero point of the length scale is located at the rear edge of the balloon on the outer surface of the front portion of the balloon applicator catheter body.
A second aspect of the present invention provides the use of an administration catheter in the treatment of rectal cancer, wherein the administration catheter is provided in accordance with the first aspect of the present invention, the administration catheter body is a rectal catheter, and in the case of a balloon administration catheter body, the catheter surface at the front of the rectal catheter has a plurality of circular or oblong holes, and no small hole is provided in the rectal catheter at the front of the balloon; in the case that the rectal catheter is a balloon administration catheter main body, the catheter surface at the front part of the rectal catheter is provided with a plurality of round holes or oblong holes, and the oval sphere at the head end of the balloon administration catheter main body is not provided with small holes; the rectal catheter positioning ring matched with the rectal catheter is a truncated cone with a curved side surface; the diameter of a through hole at the center of the rectal catheter positioning ring is equal to the outer diameter of the rectal catheter, and the through hole penetrates through the front end face and the rear end face of the rectal catheter positioning ring; the rectal catheter positioning ring can move back and forth along the rectal catheter on the rectal catheter; the front end face of the rectal catheter positioning ring with smaller diameter points to the head end of the rectal catheter, and the rear end face is in snap connection with the rectal catheter; the rectal catheter buckle and the rectal catheter positioning ring are arranged on the rectal catheter and move back and forth along the rectal catheter; after the rectal catheter buckle is pressed, the position of the rectal catheter positioning ring on the rectal catheter is fixed, and after the rectal catheter buckle is released, the rectal catheter positioning ring moves back and forth along the rectal catheter again.
Preferably, the rectal catheter positioning ring is made of a high polymer material.
A third aspect of the present invention provides a use of an administration catheter for the treatment of prostate cancer, wherein the administration catheter is provided in accordance with the first aspect of the present invention, the administration catheter body being a prostate catheter, the prostate catheter being a balloon administration catheter body, the catheter surface of the front portion of the prostate catheter having a plurality of circular or oblong holes thereon; a small part of the prostate catheter in front of the air sac is not provided with small holes, and in the case of the balloon drug delivery catheter main body, the catheter surface in front of the prostate catheter is provided with a plurality of round holes or oblong holes, and the oval balloon at the head end of the balloon drug delivery catheter main body is not provided with small holes; the prostate duct positioning ring matched with the prostate duct is a cylinder; the diameter of a through hole at the center of the prostate duct positioning ring is equal to the outer diameter of the prostate duct, and the through hole penetrates through the front end face and the rear end face of the positioning ring; the prostate duct positioning ring moves back and forth along the prostate duct on the prostate duct; the front end face of the prostate duct positioning ring is directed to the head end of the prostate duct, and the rear end face is connected with the prostate duct in a buckling way; after the prostate duct is pressed and buckled, the position of the prostate duct positioning ring on the prostate duct is fixed; after the prostate duct buckle is released, the prostate duct positioning ring moves back and forth along the prostate duct again.
Preferably, the prostate catheter positioning ring is made of a high polymer material.
A fourth aspect of the invention provides the use of an administration catheter in the treatment of bladder cancer, wherein the administration catheter is provided in accordance with the first aspect of the invention, the administration catheter body being a bladder catheter, the bladder catheter being a balloon administration catheter body, the bladder catheter having a small portion of its bladder catheter surface in front of the balloon having a plurality of apertures therein, the bladder catheter having no apertures in other surfaces thereof; in the case that the bladder catheter is a balloon administration catheter main body, no small holes are formed in the surface of the bladder catheter, and a plurality of small holes are formed in an elliptic sphere at the head end of the balloon administration catheter; the bladder catheter positioning ring matched with the bladder catheter is a cylinder; the diameter of a through hole at the center of the bladder catheter positioning ring is equal to the outer diameter of the bladder catheter, and the through hole penetrates through the front end face and the rear end face of the positioning ring; the bladder catheter positioning ring moves back and forth along the bladder catheter on the bladder catheter; the front end face of the bladder catheter positioning ring points to the head end of the bladder catheter, and the rear end face is connected with the bladder catheter in a buckling way; after the bladder catheter is pressed and buckled, the position of the bladder catheter positioning ring on the bladder catheter is fixed; after the bladder catheter buckle is released, the bladder catheter positioning ring moves back and forth along the bladder catheter again.
Preferably, the bladder catheter positioning ring is made of a high polymer material.
A fifth aspect of the present invention is to provide a rectal catheter-based rectal cancer treatment system, comprising the administration catheter provided in the first aspect being a rectal catheter, further comprising a delivery hose and a drug bag; the drug delivery hose is used for connecting the drug bag with a rectal catheter joint at the rear end of the rectal catheter, a valve is arranged on the drug delivery hose, and after the valve is opened, the liquid medicine in the drug bag enters the rectal catheter through the drug delivery hose and the rectal catheter joint.
A sixth aspect of the present invention is to provide a prostate catheter-based prostate cancer treatment system, comprising the administration catheter provided in the first aspect is a prostate catheter, and further comprising a drug delivery hose and a drug bag; the medicine delivery hose is used for connecting the medicine bag with the prostate catheter connector at the rear end of the prostate catheter, a valve is arranged on the medicine delivery hose, and after the valve is opened, medicine liquid in the medicine bag enters the prostate catheter through the medicine delivery hose and the prostate catheter connector.
A seventh aspect of the present invention is to provide a bladder cancer treatment system based on a bladder catheter, comprising the administration catheter provided in the first aspect is a bladder catheter, and further comprising a drug delivery hose, a drug bag, a tee, a drainage hose and a waste liquid collection bag; the drug delivery hose connects the drug bag with the first interface of the tee joint, the liquid discharge hose connects the waste liquid collection bag with the second interface of the tee joint, and the bladder catheter joint at the rear end of the bladder catheter is connected with the third interface of the tee joint; a valve is arranged on the drug delivery hose, and after a first valve on the drug delivery hose is opened, the drug in the drug bag enters the bladder catheter through the drug delivery hose, a first connector of the tee joint and a connector at the rear end of the bladder catheter; the liquid discharge hose is provided with a valve, the first valve on the drug delivery hose is closed, after the second valve on the liquid discharge hose is opened, liquid medicine and urine in the bladder of a patient enter the bladder catheter through the oval ball at the head end of the bladder catheter or the small part of small hole on the bladder catheter in front of the air sac, and then enter the waste liquid collecting bag after passing through the bladder catheter joint at the rear end of the bladder catheter, the second port of the tee joint and the second valve.
The drug delivery catheter, the application and the treatment system thereof provided by the invention have the following beneficial effects:
(1) The medicine applying catheter is used for accurately positioning cancer focus, and solves the problem that the medicine treating effect is reduced due to the destruction and loss of active ingredients in oral medicine caused by biochemical actions such as a large amount of gastric acid, digestive enzyme, liver first pass effect and the like;
(2) Compared with the traditional method of using the chemotherapeutic drug by dipping the whole body with rain and dew, the drug is directly contacted with the cancer focus and tissues which are infiltrated by cancer cells around the focus, so that the drug treatment intensity of the local cancer focus is intensively improved, and the problem of drug dosage is solved;
(3) The medicine consumption at the cancer focus is relatively less, the medicine consumption cost is greatly reduced, and the problem of high and resident cancer treatment cost is solved;
(4) Solves the problem of strong side effect brought to patients by systemic administration in the traditional cancer drug treatment process;
(5) Solves the problem of the optimal route for directly delivering the drug to the cancer focus;
(6) The technical problem of flexible and controllable treatment management of patients is solved;
(7) Can be used for the treatment of various cancers introduced into the body through the administration catheter, and is particularly suitable for the treatment of cancer patients with rectal cancer, prostatic cancer and bladder cancer.
Drawings
FIG. 1-1 is a schematic view of a balloon catheter according to the present invention in a sleep state;
FIGS. 1-2 are schematic views of a balloon catheter according to the present invention in an operative condition;
FIG. 2 is a schematic view of the structure of the colorectal catheter according to the present invention;
FIG. 3 is a schematic view of the structure of the rectal catheter positioning ring according to the present invention;
FIG. 4 is a schematic diagram of the operation of the system for treating a colorectal catheter according to the present invention;
FIG. 5 is a schematic view of a balloon catheter according to the present invention;
FIG. 6 is a schematic view of the structure of the positioning ring of the prostate catheter and the bladder catheter according to the present invention;
FIG. 7 is a schematic diagram of the operation of the prostate catheter treatment system of the present invention;
fig. 8 is a schematic diagram of the working principle of the bladder catheter treatment system according to the invention.
Detailed Description
In order to better understand the above technical solutions, the following detailed description will be given with reference to the accompanying drawings and specific embodiments.
It should be noted that the cancer focus of application of the catheter, application and therapeutic system may be the mucosal layer on the inner surface of the organ, the cancer tissue in the muscular layer or serosa layer and the tissue infiltrated by cancer cells, or it may be the cone-shaped, sheet-shaped, egg-shaped, petal-shaped, bean-shaped or any shape of the tissue of interest or harder type of cancer; but also cancerous tissue grown in organ tissue.
Example 1
An applicator catheter comprising:
the medical administration catheter comprises an administration catheter body, a catheter body and a catheter body, wherein the administration catheter body is a disposable medical consumable, and is discarded after use; wherein the drug delivery catheter body is a hollow catheter. In this embodiment, the length of the applicator catheter body is 200-600mm; the drug delivery catheter body is two different catheters of a balloon drug delivery catheter body and a balloon drug delivery catheter body. The length of insertion of the main body of the administration catheter into the rectum or urethra is determined according to the examination items and instructions such as X-ray film, clinical diagnosis book and catheter instruction manual related to the administration catheter before treatment, etc., the distance between the cancer focus of the patient and the anus, the length of the rectum, and the length of the inner orifice of the urinary bladder and urethra of the patient from the penis or the outer urethral orifice.
As a preferred embodiment, for a balloon applicator catheter body, a non-porous hollow oval balloon or a porous hollow oval balloon is provided at the head end of the applicator catheter body, the long axis of the non-porous hollow oval balloon or the porous hollow oval balloon being coincident with the centerline of the applicator catheter body, the short axis of the non-porous hollow oval balloon or the porous hollow oval balloon being greater than the outer diameter of the applicator catheter body; the rear end of the ball administration catheter body is provided with a ball administration catheter connector.
As a preferred embodiment, the balloon applicator catheter body and the non-porous hollow oval balloon or the porous hollow oval balloon are both made of a medical polymeric material, and the outer surfaces of the applicator catheter body and the non-porous hollow oval balloon or the porous hollow oval balloon are coated with a hydrophilic coating.
As a preferred embodiment, for the balloon applicator catheter body, a balloon is provided on the outer surface of the front portion of the balloon applicator catheter body; the balloon is tightly wrapped on the outer surface of the balloon administration catheter body; the air bag is an annular air bag when inflated; leaving a small portion of the balloon applicator catheter body in front of the balloon after the balloon applicator catheter body passes through the balloon; the head end of the air bag pesticide applying catheter main body is provided with an arc-shaped cap to seal the head end of the air bag pesticide applying catheter main body; the rear part of the air sac pesticide application catheter main body is provided with a branch catheter and a valve connected with the branch catheter; a thin conduit disposed within the catheter body connects the valve to the balloon; the air bag is tightly wrapped on the outer surface of the air bag drug application catheter main body when entering the body; after the main body of the air sac dispensing catheter enters a natural cavity or an organ of a human body and reaches a set position, a rubber balloon or an injector is used for injecting gas or water into the air sac through the valve on the branch catheter and the thin catheter so as to bulge the air sac; the gas or water in the air bag is discharged out of the air bag through the valve on the fine guide pipe and the branch guide pipe; the rear end of the balloon administration catheter main body is provided with a balloon administration catheter connector.
As a preferred embodiment, the balloon applicator catheter body and the balloon are both made of a medical polymer material, and the outer surface of the balloon applicator catheter body is coated with a hydrophilic coating, and the outer surface of the balloon is coated with or not coated with a hydrophilic coating.
As a preferred embodiment, the medical device further comprises a positioning ring arranged on the main body of the administration catheter, wherein the positioning ring is a disposable medical consumable and is discarded after use; a length scale matched with the positioning ring is printed or added on the outer surface of the medicine application catheter main body; for a balloon administration catheter body, the zero point of the length scale is positioned at the joint of the head end of the administration catheter body and a non-porous hollow oval balloon or a porous hollow oval balloon; for balloon applicator catheter bodies, the zero point of the length scale is located at the rear edge of the balloon on the outer surface of the front portion of the balloon applicator catheter body.
The scale on the catheter indicates the length of the portion of the catheter tip that has entered the patient's natural orifice. X-ray films, clinical diagnostic books and catheter instruction books of patients clearly indicate the distance of the rectal cancer focus from the anus, the length of the rectum, and the distance of the inner orifice of the urinary bladder to the penis or the outer urethral orifice. For example, the length of the rectum of a chinese person is 120-150mm. The urethra length of Chinese male is 180-220mm. The male has more curvature and smaller diameter urethra, so the patient feels pain when the catheter is inserted. The urethra length of Chinese female is 40-60mm. The female urethra has no curvature and a larger diameter, so that the patient feels less pain when the catheter is inserted.
According to the different positions of the administration catheter applied to natural cavities, organs and cancer focuses in human bodies, the administration catheter is divided into a rectal catheter, a prostate catheter and a bladder catheter which are respectively used for rectal cancer administration and treatment, prostate cancer administration and treatment and bladder cancer administration and treatment. The positioning rings corresponding to the classification of the catheter are a rectal catheter positioning ring, a prostate catheter positioning ring and a bladder catheter positioning ring, respectively.
Example two
The application of the drug delivery catheter in the treatment of rectal cancer is that the drug delivery catheter main body is a rectal catheter, and in the case that the rectal catheter is a balloon drug delivery catheter main body, the catheter surface at the front part of the rectal catheter is provided with a plurality of round holes or oblong holes, and a small part of the rectal catheter at the front part of the balloon is not provided with small holes; in the case that the rectal catheter is a balloon administration catheter main body, the catheter surface at the front part of the rectal catheter is provided with a plurality of round holes or oblong holes, and the oval sphere at the head end of the balloon administration catheter main body is not provided with small holes; the rectal catheter positioning ring matched with the rectal catheter is a truncated cone with a curved side surface, and is made of a high polymer material; the diameter of a through hole at the center of the rectal catheter positioning ring is equal to the outer diameter of the rectal catheter, and the through hole penetrates through the front end face and the rear end face of the rectal catheter positioning ring; the rectal catheter positioning ring can move back and forth along the rectal catheter on the rectal catheter; the front end face of the rectal catheter positioning ring with smaller diameter points to the head end of the rectal catheter, and the rear end face is in snap connection with the rectal catheter; the rectal catheter buckle and the rectal catheter positioning ring are arranged on the rectal catheter and move back and forth along the rectal catheter; after the rectal catheter buckle is pressed, the position of the rectal catheter positioning ring on the rectal catheter is fixed, and after the rectal catheter buckle is released, the rectal catheter positioning ring moves back and forth along the rectal catheter again.
The application method of the drug delivery catheter in the treatment of rectal cancer comprises the following steps:
(1) Before using the rectal catheter, the patient finishes defecation and enema cleaning of rectum and sigmoid colon; clean rectum and sigmoid colon are important guarantees for the therapeutic effect of the direct contact treatment method of the rectal catheter;
(2) Before the rectal catheter enters the rectum, firstly, determining the distance from the focus of the rectum cancer to the anus and the rectal length of a patient according to X-ray films, clinical diagnosis books and manual use of the catheter; in this embodiment, first, the height, weight and sex of the patient are determined; second, the patient's corresponding rectal length is found in a table in the catheter instruction manual. The rectum length of Chinese men and women is 120-150mm;
(3) Moving the rectal catheter positioning ring, and arranging the front end surface of the rectal catheter positioning ring at a scale mark equal to the length of the rectum of the patient to compress the rectal catheter buckle;
(4) The rectal catheter is inserted into the rectum until the distal end of the rectal catheter positioning ring hits the anus and cannot be inserted further. The head end with smaller diameter of the rectal catheter positioning ring enters the anus of the patient, and the curved side surface clings to the skin surface around the anus and blocks the anus, so that the medicine is prevented from flowing out of the anus; in fact, when the rectal catheter positioning ring reaches the anus opening and can not be inserted continuously, the oval ball at the head end of the catheter or the air sac at the front part of the catheter already reaches the joint of the rectum and the sigmoid colon;
(5) The medicine is delivered into the rectal catheter through the joint at the rear end of the rectal catheter and enters a closed space consisting of the rectal catheter positioning ring, the oval ball or the balloon at the head end of the rectal catheter through the round hole or the oblong hole on the catheter surface at the front part of the rectal catheter. In the closed space, the cancer focus and the tissue around the focus which is infiltrated by cancer cells are directly contacted with the liquid medicine (by soaking).
The application greatly improves the treatment intensity and treatment effect of the medicines at the cancer focus and greatly reduces the dosage of the medicines. The rectal catheter not only directly sends the medicine to the focus of the rectal cancer, but also directly immerses the focus of the cancer and tissues around the focus which are infiltrated by cancer cells in the liquid medicine, thereby realizing a brand-new direct contact type treatment method, in particular:
(1) For those patients diagnosed with advanced colorectal cancer and cancer cells that have metastasized to other organs, the rectal catheter bypasses the stomach and liver with the cancer treatment drug, the original active ingredients in the drug are not lost, and the drug efficacy per unit area is greatly enhanced compared to chemotherapy and traditional drug treatment;
(2) A direct contact type treatment method of the rectal catheter directly contacts a rectal cancer focus and tissues infiltrated by cancer cells around the focus with a cancer treatment liquid medicine for a reasonable treatment time without affecting normal movement and life, greatly improves the medicine treatment intensity of the cancer focus and has better treatment effect;
(3) The mucous membrane layer and the submucosa on the surface of the rectum are provided with rich micro-blood vessels, so that the active ingredients in the medicine are absorbed quickly; the original active ingredients in the cancer therapeutic drugs enter the micro-blood vessels through the mucous membrane layer and submucosa penetrating the rectum and participate in the treatment of other metastatic cancers in the body through blood and large circulation.
Example III
An application of an application catheter in treating prostate cancer, wherein the application catheter body is a prostate catheter, and in the case of the application catheter body of a balloon application catheter body, the surface of the catheter at the front part of the prostate catheter is provided with a plurality of round holes or oblong holes, and a small part of the prostate catheter at the front part of the balloon is not provided with small holes; in the case that the prostate catheter is a balloon drug delivery catheter main body, the catheter surface at the front part of the prostate catheter is provided with a plurality of round holes or oblong holes, and the oval sphere at the head end of the balloon drug delivery catheter main body is not provided with small holes; the prostate duct positioning ring matched with the prostate duct is a cylinder; the prostate duct positioning ring is made of high polymer materials, the diameter of a through hole in the center of the prostate duct positioning ring is equal to the outer diameter of the prostate duct, and the through hole penetrates through the front end face and the rear end face of the prostate duct positioning ring; the prostate duct positioning ring moves back and forth along the prostate duct on the prostate duct; the front end face of the prostate duct positioning ring is directed to the head end of the prostate duct, and the rear end face is connected with the prostate duct in a buckling way; after the prostate duct is pressed and buckled, the position of the prostate duct positioning ring on the prostate duct is fixed; after the prostate duct buckle is released, the prostate duct positioning ring moves back and forth along the prostate duct again.
The application method of the application catheter in treating the prostate cancer comprises the following steps:
(1) Before the prostate duct enters the urethra, firstly, determining the distance from the bladder urethra inner orifice of a patient to the penis outer urethra orifice according to X-ray films, clinical diagnosis books or the duct using manual;
(2) Moving the prostate duct positioning ring and arranging the front end surface of the prostate duct positioning ring at a scale mark equal to the distance from the inner orifice of the bladder urethra to the outer urethral orifice of the penis to press the prostate duct buckle;
(3) The prostate catheter is inserted into the urethra until the front end surface of the prostate catheter positioning ring hits the external urethral orifice of the penis.
(4) The medicine is delivered into the prostate duct through the joint at the rear end of the prostate duct and enters into a closed space formed by the prostate duct positioning ring, the urethra and the oval ball or the air sac at the head end of the prostate duct through a plurality of round holes or oblong holes at the front part of the prostate duct. Left and right vas deferens outlets of the prostate are located in the enclosed space. In the enclosed space, a portion of the drug enters the vas deferens and permeates through the mucosal, muscular and adventitial layers of the vas deferens into the middle lobe of the prostate. After penetrating into the prostate capsule through the mucosal, submucosal and musculature of the urethra, part of the drug enters the anterior, zuo She and right and middle lobes of the prostate.
As a preferred embodiment, the use of one prostate catheter and one rectal catheter simultaneously provides a better therapeutic effect on prostate cancer than the use of one prostate catheter alone in patients with prostate cancer. The rectal catheter penetrates into the posterior, zuo She and right lobes of the prostate through the mucosal, submucosal, myometrial and serosal layers of the rectum in an enclosed space created in the patient's rectum, and then into the middle lobe. In a closed space established by the prostate catheter, part of the medicine enters the middle lobe of the prostate through the left and right vas deferens, and part of the medicine permeates to the front lobe, zuo She and the right lobe of the prostate through the urethral mucosa layer, submucosa and muscular layer, and then enters the middle lobe. The joint participation of the prostate catheter and the rectal catheter enables more medicaments to simultaneously perform an omnidirectional targeted therapy on the prostate cancer.
Example IV
Use of an applicator catheter for the treatment of bladder cancer, said applicator catheter body being a bladder catheter, said bladder catheter being a balloon applicator catheter body, said bladder catheter having no apertures in its surface, said small portion of the bladder catheter surface in front of the balloon having a plurality of apertures therein; in the case that the bladder catheter is a balloon catheter body, no small holes are formed in the surface of the bladder catheter, and a plurality of small holes are formed in an elliptic sphere at the head end of the balloon catheter. The bladder catheter positioning ring is identical to the prostate catheter positioning ring. The bladder catheter positioning ring matched with the bladder catheter is a cylinder; the bladder catheter positioning ring is made of high polymer materials, the diameter of a through hole in the center of the bladder catheter positioning ring is equal to the outer diameter of the bladder catheter, and the through hole penetrates through the front end face and the rear end face of the bladder catheter positioning ring; the bladder catheter positioning ring moves back and forth along the bladder catheter on the bladder catheter; the front end face of the bladder catheter positioning ring points to the head end of the bladder catheter, and the rear end face is connected with the bladder catheter in a buckling way; after the bladder catheter is pressed and buckled, the position of the bladder catheter positioning ring on the bladder catheter is fixed; after the bladder catheter buckle is released, the bladder catheter positioning ring moves back and forth along the bladder catheter again.
The application method of the application catheter in the treatment of bladder cancer comprises the following steps:
(1) Before the bladder catheter enters the urethra, firstly, determining the distance from the inner orifice of the bladder urethra of a patient to the penis or the urethra orifice outside the urethra according to X-ray films, clinical diagnosis books or manual use of the catheter;
(2) Moving the bladder catheter positioning ring, arranging the front end surface of the bladder catheter positioning ring at a scale equal to the distance from the inner orifice of the bladder urethra to the penis or the outer urethral orifice of the urethra, and pressing the bladder catheter buckle;
(3) The bladder catheter is inserted into the urethra until the front end surface of the bladder catheter positioning ring hits the penis or the external urethral orifice. At this point, the small portion of the surface of the bladder catheter in front of the oval sphere or balloon of the head end of the bladder catheter is located in the bladder with a plurality of small holes. After entering the bladder catheter through a delivery hose and a first port of a tee, the drug enters the bladder through a plurality of small holes in the oval sphere at the head end of the bladder catheter or in the surface of the bladder catheter of the small portion in front of the balloon. In the bladder, the medicine soaks the cancer focus in the bladder and the tissues infiltrated by cancer cells around the focus into the medicine liquid, so that the medicine treatment intensity and treatment effect of the cancer focus are greatly improved. When the patient has a need of urination in the treatment process or the treatment period time is up, the valve on the drug delivery hose is closed, and the valve on the liquid discharge hose is opened. The medicine and urine in the bladder enter the waste liquid collecting bag through the joint at the rear end of the bladder catheter, the second joint of the tee joint and a drain hose. The bladder catheter directly delivers the cancer therapeutic drug to the cancer focus on the bladder mucosa layer, the muscle layer and the adventitia layer, and directly immerses the cancer focus and tissues infiltrated by cancer cells around the focus in the liquid medicine, thereby realizing a direct contact type therapeutic method.
As a preferred embodiment, suitable calculation means for the drug dose include:
and calculating according to a calculation formula of the body surface area of the patient to obtain the accurate dosage of the chemotherapeutic medicine. Body surface area is calculated based on the sex, weight and height of the patient. Thus, the dosage of the chemotherapeutic agent used and the distribution of the agent within the patient's body are affected by body weight. The administration catheter is a target-type local administration and treatment device, and can be used for directly soaking the medicine and cancer cells on the inner surface of a natural cavity or organ of a patient in a cancer treatment liquid medicine. The internal surface area (weight) of the part of the natural lumen and organs including the cancer lesion is relatively tens or hundreds of times smaller than the surface area (weight) of the human body of the patient. Therefore, the local administration mode of the target point type of the administration catheter and the direct contact treatment method lead the administration dosage of the administration catheter to be tens or hundreds of times smaller than the systemic administration dosage of the traditional chemotherapy. Chemotherapy is a major means of cancer treatment widely used in clinic, and has better therapeutic effects on systemic high-sensitivity cancers (such as leukemia and lymphoma), but has limitations on the therapeutic effects of medium-sensitivity cancers (such as rectal cancer, prostate cancer and bladder cancer), including (but not limited to): first, chemotherapy is administered to the patient's body weight, not at the target site, and therefore is administered in relatively large amounts. Second, chemotherapy drugs kill cancer cells while also killing a large number of normal cells, which is one of the reasons why patients suffer from great pain and strong side effects after chemotherapy. Third, systemic administration of chemotherapy is a "rain and dew" approach, and does not focus on drug efficacy for high intensity and high dose treatment of cancer lesions and tissues surrounding the lesions that are infiltrated by cancer cells.
The targeted local administration method and the direct contact treatment method of the administration catheter are different from the traditional chemotherapy drugs and treatment methods. Advantages of the delivery catheter include (without limitation): first, compared with systemic administration of conventional chemotherapeutic agents, the administration catheter can accurately administer drugs locally at the cancer focus, greatly reducing the dosage of the drugs. Second, the course of treatment of the delivery catheter does not cause any side effects to the patient. Thirdly, original active ingredients in the medicine are not destroyed and lost by biochemical actions such as gastric acid, digestive enzyme, liver first pass effect and the like, so that the original active ingredients and therapeutic efficacy of the medicine are greatly maintained. Fourth, compared with the traditional systemic administration of chemotherapeutics, the local administration mode of the target site mode of the administration catheter greatly reduces the dosage of the drugs, but the action intensity of the drugs in unit area (weight) of cancer lesions is improved by tens of times or hundreds of times compared with the traditional administration mode. Fifth, the administration catheter can be used without affecting the feeding, excretion and normal rest of the patient, so that the treatment of the patient is greatly improved, the living environment and the quality are improved, and the treatment process is more humanized. Sixth, compared with the traditional complex treatment process, the administration catheter is more flexible, convenient, reasonable and efficient, and the administration time, the treatment period and the whole treatment process can be managed in an informationized, automatic and scientific way through a computer. Seventh, the administration catheter has the characteristics of simple operation, convenient use and lower cost, and can be widely used in various hospitals and can be self-operated by patients in emergency.
This example uses an administration catheter during the treatment of more than tens of cancers such as rectal cancer, bladder cancer, and prostate cancer. In comparison with the results of clinical trials of the same drug without the administration catheter, it was found that the tumor volume of all drug treatments using the administration catheter rapidly decreased a few days after local administration of the cancer lesions (typically within a week). After several months, X-ray or CT detection has failed to detect the trace of the cancer lesion. After treatment, most patients excrete the residues after "resolution" of the tumor focus, i.e. "tumor flesh" in the form of multiple humidities. Three tumors of egg size and pigeon egg size respectively exist in the bladder of one bladder cancer patient, disappear rapidly after one week of treatment, and the patient's urethra discharges discrete tumor fibers wrapped by meat emulsion. Clinical trials of cancer treatment drugs in combination with drug delivery catheters have demonstrated not only that the targeted local delivery of drug delivery catheters is more pronounced than the systemic delivery of the same drug, but that the targeted local delivery of drug delivery catheters is a rational and practical effective treatment device and method for rectal, bladder and prostate cancer, as compared to traditional (drug systemically dispersed) delivery modalities, including oral, chemotherapy and radiation.
As a preferred embodiment, the administration catheter may be derived from bronchial, esophageal, ureteral and renal catheters, uterine, pancreatic and biliary tract catheters, lacrimal gland catheters, bone cavity marrow catheters, otorhinolaryngological catheters, gastric and colonic catheters, according to the description and mode of use of the rectal catheter, the bladder catheter and the prostate catheter described above. All of the above-derived administration catheters can be used for the administration of bronchogenic carcinoma, esophageal carcinoma, ureteral and renal carcinoma, cervical cancer, endometrial carcinoma, ovarian carcinoma, pancreatic and biliary tract carcinoma, lacrimal gland, bone cavity marrow carcinoma, otorhinolaryngocarcinoma, gastric carcinoma, colon carcinoma, and any cancer that can be treated in the natural lumen and organs of the human body using the catheter administration, respectively.
Example five
A rectal cancer treatment system based on a rectal catheter comprises the rectal catheter according to the first embodiment, and further comprises a drug delivery hose and a drug bag, wherein the drug delivery hose is used for connecting the drug bag with a rectal catheter connector at the rear end of the rectal catheter, a valve is arranged on the drug delivery hose, and after the valve is opened, liquid medicine in the drug bag enters the rectal catheter through the drug delivery hose and the rectal catheter connector.
Example six
The prostate cancer treatment system based on the prostate duct comprises the prostate duct in the first embodiment, and further comprises a medicine delivery hose and a medicine bag, wherein the medicine delivery hose is used for connecting the medicine bag with a prostate duct joint at the rear end of the prostate duct, a valve is arranged on the medicine delivery hose, and after the valve is opened, medicine liquid in the medicine bag enters the prostate duct through the medicine delivery hose and the prostate duct joint.
Example seven
A bladder cancer treatment system based on a bladder catheter comprises the bladder catheter according to the first embodiment, and further comprises a drug delivery hose, a drug bag, a tee joint, a drainage hose and a waste liquid collecting bag. The drug delivery hose connects the drug bag with the first interface of the tee joint, the liquid discharge hose connects the waste liquid collecting bag with the second interface of the tee joint, and the bladder catheter is connected with the third interface of the tee joint through a bladder catheter connector at the rear end of the bladder catheter. After a first valve on the drug delivery hose is opened, the drug in the drug bag enters the bladder catheter through the drug delivery hose, a first connector of the tee joint and a connector at the rear end of the bladder catheter; after the first valve on the drug delivery hose is closed and the second valve on the liquid discharge hose is opened, the liquid medicine and urine in the bladder of the patient enter the bladder catheter through the oval ball at the head end of the bladder catheter or the small part of small hole on the bladder catheter in front of the air bag, and then enter the waste liquid collecting bag after passing through the bladder catheter joint at the rear end of the bladder catheter, the second port of the tee joint and the second valve.
Fig. 1-1 is a schematic view of a balloon catheter in a "sleep" state. A balloon catheter 1 is shown with a balloon 2 provided on the outer surface of the front part of the catheter. When not inflated or hydrated, the balloon 2 is tightly wrapped around the outer surface of the balloon catheter 1. A small portion of the catheter still remains in front of the balloon 2 as the tip catheter 3. The balloon catheter 1 and the tip catheter 3 are the same catheter, and the inside is communicated. The head end of the tip catheter 3 is closed. The rear end of the balloon catheter 1 is provided with a catheter adapter 4. The rear part of the balloon catheter 1 is provided with a sub-catheter 7 and is connected to a valve 8. The catheter positioning ring 5 and the catheter clip 6 are positioned on the balloon catheter 1. The outer surface of the balloon catheter 1 is printed with scales of a length scale, and the zero point of the scales is positioned at the rear edge of the balloon 2.
Fig. 1-2 are schematic views of a balloon catheter in an "on" state. In the operating state of a balloon catheter 1 shown in the figures, gas or water from outside the balloon catheter 1 passes through a valve 8 and a thin catheter located in the catheter 7 and the balloon catheter 1 enters the balloon 2, so that the balloon 2 bulges.
Figure 2 shows a schematic view of a colorectal catheter. A rectal catheter 1 'is shown, a non-porous hollow oval sphere 9 is arranged on the head end of the rectal catheter 1', and a rectal catheter joint 4 'is arranged on the rear end of the rectal catheter 1'. A curved frustoconical shaped rectal catheter positioning ring 5' and a rectal catheter clip 6' are positioned on the rectal catheter 1 '. The outer surface of the rectal catheter 1 'is printed with scales of a length scale, and the zero point of the scales is positioned at the joint of the head end of the rectal catheter 1' and the non-porous hollow elliptic sphere 9.
Figure 3 shows a schematic view of a rectal catheter positioning ring. The catheter positioning ring shown in the figure is a rectal catheter positioning ring 5', which is a curved truncated cone of revolution. The side surface of the rectal catheter positioning ring 5' is a curved surface. The rear end face of the rectal catheter positioning ring 5 'is connected with the lower semicircle of a rectal catheter buckle 6'. The openings of the upper semicircle and the lower semicircle of the rectal catheter buckle 6' are provided with a toothed buckle (not shown in the figure). The upper semicircle of the rectal catheter buckle 6 'is pressed downwards, the upper semicircle and the lower semicircle of the rectal catheter buckle 6' are locked by the tooth-shaped buckle, and the rectal catheter positioning ring 5 'is fixed on the rectal catheter 1'. After the toothed buckle of the rectal catheter buckle 6 'is released, the rectal catheter positioning ring 5' can move back and forth along the rectal catheter 1 'on the rectal catheter 1'.
Fig. 4 is a schematic diagram showing the working principle of a colorectal catheter treatment system. A delivery hose 11 is shown connecting the drug bag 12 to the rectal catheter hub 4 'at the rear end of the rectal catheter 1'. After opening the first valve 10 on the delivery hose 11, the liquid medicine in the bag 12 is introduced into the rectal catheter 1 'through the delivery hose 11 and the rectal catheter adapter 4'.
Figure 5 shows a schematic view of a balloon catheter. The figure shows a bladder catheter 1 ", the head end of the bladder catheter 1" being provided with a perforated hollow oval sphere 9', the perforated hollow oval sphere 9' being provided with a plurality of small holes. A bladder catheter positioning ring 13 and a bladder catheter buckle 14 are arranged on the bladder catheter 1 ''. The rear end of the bladder catheter 1 'is provided with a bladder catheter adapter 4'. The outer surface of the bladder catheter 1' is printed with scales of a length scale, and the zero points of the scales are positioned at the joint of the head end of the bladder catheter 1' and the hollow elliptic sphere 9 '.
Fig. 6 shows a schematic view of a bladder catheter positioning ring, which is of course known to those skilled in the art to be equally applicable to a prostate catheter. A bladder cylinder positioning ring 13 is shown. The back end face of the bladder cylinder positioning ring 13 is connected with the lower semicircle of the bladder catheter buckle 14. The openings of the upper semicircle and the lower semicircle of the bladder catheter buckle 14 are provided with a toothed buckle (not shown in the figure). The upper semicircle of the bladder catheter buckle 14 is pressed downwards, the upper semicircle and the lower semicircle of the bladder catheter buckle 14 are locked by the toothed buckle, and the bladder cylinder positioning ring 13 is fixed on the catheter. After the toothed buckle of the bladder catheter buckle 14 is released, the bladder cylinder positioning ring 13 can move back and forth along the catheter on the bladder catheter again.
Fig. 7 is a schematic diagram showing the operation of a prostate catheter treatment system. One prostate catheter 1' "is shown in the figures, the prostate catheter 1 '" being identical compared to the colorectal catheter 1' described in fig. 2, except for the difference in positioning ring and catheter snap. A medication delivery hose 11 connects the medication bag 12 to the prostatic catheter adapter 4 '"at the rear end of the prostatic catheter 1'". After opening the first valve 10 on the delivery hose 11, the medical fluid in the medical bag 12 is introduced into the prostate catheter 1 '"through the delivery hose 11 and the prostate catheter adapter 4'".
Figure 8 is a schematic diagram of the operation of a bladder catheter treatment system. A bladder catheter 1 'is shown, a delivery hose 11 connecting the drug bag 12 to a tee 15 and a bladder catheter fitting 4 "at the rear end of the bladder catheter 1'. After opening the first valve 10 on the delivery hose 11, the drug in the drug bag 12 enters the bladder catheter 1 "through the delivery hose 11, the first port of the tee 15 and the bladder catheter adapter 4". After the first valve 10 on the drug delivery hose 11 is closed and the second valve 16 on the drain hose 17 is opened, the liquid medicine and urine in the bladder of the patient enter the bladder catheter 1 'through the small hole on the hollow oval ball 9' with holes at the head end of the bladder catheter 1', and then enter the waste liquid collecting bag 18 after passing through the bladder catheter joint 4″ at the rear end of the bladder catheter 1', the third joint, the second joint and the second valve 16 in the tee joint 15.
In the present embodiment, the first valve 10 and the second valve 16 are wedge-shaped valves, however, those skilled in the art will recognize that other types of valves may be used as appropriate for the respective application.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention. It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (8)
1. An applicator catheter, comprising:
the drug delivery catheter comprises a drug delivery catheter body and a positioning ring arranged on the drug delivery catheter body, wherein the drug delivery catheter body is a hollow catheter; the drug delivery catheter body is a balloon drug delivery catheter body or a balloon drug delivery catheter body; forming a closed space for administration and treatment in the natural cavity and organs of the human body through a ball or a balloon on the administration catheter body based on the positioning ring arranged on the administration catheter body;
For the balloon administration catheter main body, a non-porous hollow elliptic sphere or a porous hollow elliptic sphere is arranged at the head end of the balloon administration catheter main body, the long axis of the non-porous hollow elliptic sphere or the porous hollow elliptic sphere is coincident with the central line of the balloon administration catheter main body, and the short axis of the non-porous hollow elliptic sphere or the porous hollow elliptic sphere is larger than the outer diameter of the balloon administration catheter main body; the rear end of the ball pesticide application catheter main body is provided with a ball pesticide application catheter connector;
for a balloon applicator catheter body, providing a balloon on an outer surface of a front portion of the balloon applicator catheter body; the balloon is tightly wrapped on the outer surface of the balloon administration catheter body; the air bag is an annular air bag when inflated; leaving a small portion of the balloon applicator catheter body in front of the balloon after the balloon applicator catheter body passes through the balloon; the head end of the air bag pesticide applying catheter main body is provided with an arc-shaped cap to seal the head end of the air bag pesticide applying catheter main body; the rear part of the air sac pesticide application catheter main body is provided with a branch catheter and a valve connected with the branch catheter; a thin conduit disposed within the catheter body connects the valve to the balloon; the air bag is tightly wrapped on the outer surface of the air bag drug application catheter main body when entering the body; after the main body of the air sac dispensing catheter enters a natural cavity or an organ of a human body and reaches a set position, a rubber balloon or an injector is used for injecting gas or water into the air sac through the valve on the branch catheter and the thin catheter so as to bulge the air sac; the gas or water in the air bag is discharged out of the air bag through the valves on the fine guide pipe and the branch guide pipe; the rear end of the balloon administration catheter main body is provided with a balloon administration catheter connector.
2. An applicator catheter as claimed in claim 1, wherein the outer surface of the applicator catheter body is provided with a length scale for use with the retaining ring; for a balloon administration catheter body, the zero point of the length scale is positioned at the joint of the head end of the balloon administration catheter body and the non-porous hollow elliptic sphere or the porous hollow elliptic sphere; for balloon applicator catheter bodies, the zero point of the length scale is located at the rear edge of the balloon on the outer surface of the front portion of the balloon catheter body.
3. Use of an applicator catheter according to claim 1 or 2 for the treatment of rectal cancer, wherein the applicator catheter body is a rectal catheter, and wherein in the case of a balloon applicator catheter body, the catheter surface at the front of the rectal catheter has a plurality of circular or oblong holes, and wherein a small portion of the rectal catheter in front of the balloon is not provided with holes; in the case that the rectal catheter is a balloon administration catheter main body, the catheter surface at the front part of the rectal catheter is provided with a plurality of round holes or oblong holes, and no small holes are arranged on the oval sphere at the head end of the balloon administration catheter main body; the rectal catheter positioning ring matched with the rectal catheter is a truncated cone with a curved side surface; the diameter of a through hole at the center of the rectal catheter positioning ring is equal to the outer diameter of the rectal catheter, and the through hole penetrates through the front end face and the rear end face of the positioning ring; the rectal catheter positioning ring is movable back and forth along the rectal catheter on the rectal catheter; the front end face of the rectal catheter positioning ring with smaller diameter points to the head end of the rectal catheter, and the rear end face is in buckling connection with the rectal catheter; the rectal catheter buckle and the rectal catheter positioning ring are arranged on the rectal catheter and move back and forth along the rectal catheter; after the rectal catheter buckle is pressed, the position of the rectal catheter positioning ring on the rectal catheter is fixed, and after the rectal catheter buckle is released, the rectal catheter positioning ring moves back and forth along the rectal catheter again.
4. Use of the catheter according to claim 1 or 2 for the treatment of prostate cancer, wherein the catheter body is a prostate catheter, and in the case of a balloon catheter body, the catheter surface of the front part of the prostate catheter has a plurality of round holes or oblong holes, and a small part of the prostate catheter in front of the balloon has no holes; in the case that the prostate catheter is a balloon drug delivery catheter main body, the catheter surface at the front part of the prostate catheter is provided with a plurality of round holes or oblong holes, and the oval sphere at the head end of the balloon drug delivery catheter main body is not provided with small holes; the prostate duct positioning ring matched with the prostate duct is a cylinder; the diameter of a through hole at the center of the prostate duct positioning ring is equal to the outer diameter of the prostate duct, and the through hole penetrates through the front end face and the rear end face of the positioning ring; the prostate duct positioning ring moves back and forth along the prostate duct on the prostate duct; the front end face of the prostate duct positioning ring is directed to the head end of the prostate duct, and the rear end face is connected with the prostate duct in a buckling way; after the prostate duct is pressed and buckled, the position of the prostate duct positioning ring on the prostate duct is fixed; after the prostate duct buckle is released, the prostate duct positioning ring moves back and forth along the prostate duct again.
5. Use of the catheter according to claim 1 or 2 for the treatment of bladder cancer, wherein the catheter body is a bladder catheter, and wherein in the case of a balloon catheter body, a small portion of the bladder catheter in front of the balloon has a plurality of small holes in the surface of the bladder catheter, and no small holes are provided in the other surface of the bladder catheter; in the case that the bladder catheter is a balloon administration catheter main body, no small holes are formed on the surface of the bladder catheter, and a plurality of small holes are formed on an elliptic sphere at the head end of the balloon administration catheter; the bladder catheter positioning ring matched with the bladder catheter is a cylinder; the diameter of a through hole at the center of the bladder catheter positioning ring is equal to the outer diameter of the bladder catheter, and the through hole penetrates through the front end face and the rear end face of the positioning ring; the bladder catheter positioning ring moves back and forth along the bladder catheter on the bladder catheter; the front end face of the bladder catheter positioning ring points to the head end of the bladder catheter, and the rear end face is connected with the bladder catheter in a buckling way; after the bladder catheter is pressed and buckled, the position of the bladder catheter positioning ring on the bladder catheter is fixed; after the bladder catheter buckle is released, the bladder catheter positioning ring moves back and forth along the bladder catheter again.
6. A rectal cancer treatment system based on a rectal catheter, comprising the drug delivery catheter according to claim 1 or 2, and further comprising a drug delivery hose and a drug bag, wherein the drug delivery hose connects the drug bag with a drug delivery catheter connector at the rear end of the drug delivery catheter, a valve is arranged on the drug delivery hose, and after the valve is opened, the liquid medicine in the drug bag enters the drug delivery catheter through the drug delivery hose and the drug delivery catheter connector.
7. A prostate cancer treatment system based on a prostate catheter, which is characterized by comprising the drug delivery catheter as claimed in claim 1 or 2, and further comprising a drug delivery hose and a drug bag, wherein the drug delivery hose is used for connecting the drug bag with a drug delivery catheter joint at the rear end of the drug delivery catheter, a valve is arranged on the drug delivery hose, and after the valve is opened, liquid medicine in the drug bag enters the drug delivery catheter through the drug delivery hose and the drug delivery catheter joint.
8. A bladder cancer treatment system based on a bladder catheter, comprising the administration catheter of claim 1 or 2, further comprising a drug delivery hose, a drug bag, a tee, a drainage hose, and a waste collection bag; the medicine delivery hose connects the medicine bag with the first interface of the tee joint, the liquid discharge hose connects the waste liquid collecting bag with the second interface of the tee joint, and the medicine application catheter joint at the rear end of the medicine application catheter is connected with the third interface of the tee joint; a valve is arranged on the drug delivery hose, and after a first valve on the drug delivery hose is opened, the drug in the drug bag enters the drug delivery catheter through the drug delivery hose, a first connector of the tee joint and a connector at the rear end of the drug delivery catheter; the liquid discharge hose is provided with a valve, the first valve on the drug delivery hose is closed, after the second valve on the liquid discharge hose is opened, the liquid medicine and urine in the bladder of the patient enter the drug delivery catheter through the oval ball at the head end of the drug delivery catheter or a small part of small holes on the drug delivery catheter in front of the air bag, and then enter the waste liquid collecting bag after passing through the drug delivery catheter joint at the rear end of the drug delivery catheter, the second port of the tee joint and the second valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310825309.3A CN116531644A (en) | 2023-07-06 | 2023-07-06 | Accurate positioning medicine application catheter, application and treatment system thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310825309.3A CN116531644A (en) | 2023-07-06 | 2023-07-06 | Accurate positioning medicine application catheter, application and treatment system thereof |
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| CN116531644A true CN116531644A (en) | 2023-08-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202310825309.3A Pending CN116531644A (en) | 2023-07-06 | 2023-07-06 | Accurate positioning medicine application catheter, application and treatment system thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN118320278A (en) * | 2024-05-13 | 2024-07-12 | 蓝盾医疗科技(北京)有限公司 | Self-guiding drug delivery catheter, drug delivery system and use method |
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