CN116531343B - Gelling composition containing carrageenan and preparation method thereof - Google Patents
Gelling composition containing carrageenan and preparation method thereof Download PDFInfo
- Publication number
- CN116531343B CN116531343B CN202310547487.4A CN202310547487A CN116531343B CN 116531343 B CN116531343 B CN 116531343B CN 202310547487 A CN202310547487 A CN 202310547487A CN 116531343 B CN116531343 B CN 116531343B
- Authority
- CN
- China
- Prior art keywords
- rotating plate
- fixedly connected
- carrageenan
- plate
- inner cylinder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000679 carrageenan Substances 0.000 title claims abstract description 71
- 229920001525 carrageenan Polymers 0.000 title claims abstract description 71
- 229940113118 carrageenan Drugs 0.000 title claims abstract description 71
- 235000010418 carrageenan Nutrition 0.000 title claims abstract description 69
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 239000000463 material Substances 0.000 claims description 39
- 238000002156 mixing Methods 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 22
- 238000007789 sealing Methods 0.000 claims description 21
- 238000007599 discharging Methods 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 8
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 230000005574 cross-species transmission Effects 0.000 claims 7
- 239000000499 gel Substances 0.000 abstract description 33
- 108010010803 Gelatin Proteins 0.000 abstract description 22
- 239000008273 gelatin Substances 0.000 abstract description 22
- 229920000159 gelatin Polymers 0.000 abstract description 22
- 235000019322 gelatine Nutrition 0.000 abstract description 22
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 22
- 239000002994 raw material Substances 0.000 abstract description 22
- 239000007901 soft capsule Substances 0.000 abstract description 13
- 239000002775 capsule Substances 0.000 abstract description 11
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 description 12
- 239000000843 powder Substances 0.000 description 10
- 230000009977 dual effect Effects 0.000 description 9
- 239000004014 plasticizer Substances 0.000 description 9
- 229920002472 Starch Polymers 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000008107 starch Substances 0.000 description 8
- 239000000337 buffer salt Substances 0.000 description 7
- 230000006835 compression Effects 0.000 description 7
- 238000007906 compression Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000001125 extrusion Methods 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000940372 Eucheuma denticulatum Species 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 208000037516 chromosome inversion disease Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 241001233242 Lontra Species 0.000 description 3
- 241000206572 Rhodophyta Species 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 241001428166 Eucheuma Species 0.000 description 2
- 241000206671 Gelidium amansii Species 0.000 description 2
- 239000004368 Modified starch Substances 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 239000000416 hydrocolloid Substances 0.000 description 2
- 239000001341 hydroxy propyl starch Substances 0.000 description 2
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 235000019426 modified starch Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000011257 shell material Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241001474374 Blennius Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/0042—Degasification of liquids modifying the liquid flow
- B01D19/0052—Degasification of liquids modifying the liquid flow in rotating vessels, vessels containing movable parts or in which centrifugal movement is caused
- B01D19/0057—Degasification of liquids modifying the liquid flow in rotating vessels, vessels containing movable parts or in which centrifugal movement is caused the centrifugal movement being caused by a vortex, e.g. using a cyclone, or by a tangential inlet
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/02—Apparatus characterised by being constructed of material selected for its chemically-resistant properties
Abstract
The application provides a gel composition containing carrageenan and a preparation method thereof, which are applied to the field of chemical molecules, wherein the gel composition is prepared by taking mixed carrageenan consisting of iota type and v type as raw materials, so that the viscosity and the gel temperature of the gel composition can be reduced, the gel composition is relatively close to a gelatin system, and a capsule device based on the gelatin system can be used for production, thereby reducing the equipment cost of plant-based soft capsules.
Description
Technical Field
The application relates to the field of chemical molecules, in particular to a gel composition containing carrageenan and a preparation method thereof.
Background
Carrageenan is a hydrocolloid extracted from seaweed of red algae such as Eucheuma Gelatinosum, gelidium amansii, and Pelvis, and is also called Eucheuma Gelatinosum, gelidium amansii, carrageenan, and carrageenan. Carrageenan, due to the differences in the sulfate binding morphology, 7 main types of carrageenan were produced: kappa form, iota form, lambda form, gamma form, v form, xi form, mu form.
Carrageenan, a plant-derived hydrocolloid, can play an important role in plant capsules. The plant capsule is a soft and hard capsule which is prepared by taking plant extracts as raw materials, such as starch, carrageenan and the like, to replace traditional gelatin raw materials, is used for containing solid, liquid medicines and nutritional health-care foods, retains the advantages of all traditional capsules, has no peculiar smell, no preservative, no heavy metal and no animal source, is natural and green, has good heat resistance and compression resistance, and provides a new capsule selection for medicines and nutritional health-care foods.
Application No. 201080069480.7 provides a film-forming composition for soft capsules comprising an acid-decomposed waxy corn starch, a gelling agent, a plasticizer, etc., providing a film-forming composition for soft capsules comprising mainly a non-gelatin component, wherein the gelling agent is iota carrageenan.
Application No. 201580053770.5 provides a plant-based soft capsule film having high film strength and good adhesiveness and capable of giving excellent film properties, and a soft capsule containing kappa-type and iota-type carrageenan.
The application number 201610437197.4 relates to a plant capsule shell material, a soft capsule, a preparation method and application thereof, wherein the film forming agent of the plant capsule shell material is one or more of carrageenan, xanthan gum and acacia.
The plant soft capsule scheme of the existing carrageenan system is common commercial kappa-type, iota-type or kappa-type 2 Form (kappa/iota mixed) as starting material. The glue solution prepared by the carrageenan has the following characteristics: 1. the viscosity of the glue solution is large, and the viscosity of the carrageenan starch system is about 10 times of that of the gelatin system; 2. the gel temperature is high, the gel temperature of the carrageenan system glue solution is 80-90 ℃, and the gelatin system is 40-60 ℃.
At present, commonly used capsule equipment is designed based on a gelatin system, and the high viscosity and high gel temperature of a carrageenan system can cause the problems that a gelatin solution easily blocks a pipeline, a gel is difficult to form a film and the like in the production process of the gelatin capsule equipment, so that inconvenience is caused to the production of plant soft capsules.
Disclosure of Invention
The application aims to solve the problem that the prior plant soft capsule is difficult to adapt to gelatin capsule equipment, and compared with the prior art, the application provides a carrageenan-containing gelling composition, which comprises rubber powder, a plasticizer and water, wherein the rubber powder accounts for 100 parts of the gelling composition, the plasticizer accounts for 20-60 parts of the gelling composition, the water accounts for 100-200 parts of the gelling composition, and the gelatinThe powder comprises mixed carrageenan and starch, wherein the mixed carrageenan accounts for 10-40 percent of the powder, the starch accounts for 60-90 percent of the powder, the mixed carrageenan comprises iota-type carrageenan and v-type carrageenan, the iota-type carrageenan accounts for 65-90 percent of the mixed carrageenan, the v-type carrageenan accounts for 10-35 percent of the mixed carrageenan, and the gel strength of the mixed carrageenan is 15-45g/cm 2 The optimization interval is 20-40/cm 2 The starch is at least one of acid treated starch or hydroxypropyl starch, and the plasticizer is at least one of glycerol or sorbitol.
Further, the gel composition containing carrageenan further comprises buffer salt, wherein the buffer salt adopts at least one of citrate, phosphate, dihydrogen phosphate or dibasic phosphate, and the buffer salt is 0-40% of mixed carrageenan by weight.
A carrageenan-containing gelling composition, which is prepared by the following steps: the preparation is carried out by adopting a double-effect preparation device comprising an inner stirring tank and an outer defoaming tank, wherein the outer defoaming tank is sleeved on the outer side of the inner stirring tank, and the preparation method specifically comprises the following steps of:
s1, feeding: adjusting the position of the defoaming outer tank to enable the mixing inner tank and the defoaming outer tank to be in a communicated state, opening a feeding pipe on the upper side of the defoaming outer tank, and sequentially adding rubber powder, plasticizer and water into the mixing inner tank according to a proportion;
s2, preliminary inversion and mixing: rotating the defoaming outer tank by 180 degrees to ensure that the material mixing inner tank and the defoaming outer tank are not communicated with each other, and stirring, dissolving and mixing the raw materials in the material mixing inner tank in an environment of 70-98 ℃ to obtain a composition primary product;
s3, performing secondary inversion and defoaming: the defoaming outer tank is rotated for 180 degrees, the material mixing inner tank is communicated with the defoaming outer tank again, the primary composition product flows downwards along the outer wall of the material mixing inner tank in a sparse and shallow state by self-extrusion in the material mixing inner tank, bubbles in the primary composition product are exposed, and compression defoaming is realized in the process of diversion by combining extrusion of the defoaming outer tank;
s4, discharging: the prepared gelled composition was collected by opening the discharge pipe on the lower side of the defoaming outer tank.
Further, a stirring inner tank used in the preparation method comprises an inner cylinder with two ends connected with supporting seats, a flash channel is formed in the upper end of the inner cylinder, a fixed rotating plate and a movable rotating plate are rotatably connected in the inner cylinder, one end of the fixed rotating plate, which is close to the movable rotating plate, is fixedly connected with a plurality of stirring rods which are uniformly distributed, and the stirring rods penetrate through the movable rotating plate and are slidably connected in the inner cylinder.
Further, the outer end fixedly connected with motor that is close to the support of fixed commentaries on classics board, the output activity of motor run through support and inner tube and with the outer end fixed connection of fixed commentaries on classics board, the inner wall fixedly connected with electric putter that the inner tube was kept away from to fixed commentaries on classics board, electric putter's flexible end fixedly connected with T type pivot, T type pivot swivelling joint is kept away from the one end of fixed commentaries on classics board in moving the commentaries on classics board.
Further, the defoaming outer tank used in the preparation method comprises a pair of positioning rings sleeved at the outer end of the inner cylinder, a sealing plate, an arc plate and a pair of waterproof elastic coiled materials are fixedly connected between the pair of positioning rings, the sealing plate and the arc plate are respectively and fixedly connected between two ends of the pair of waterproof elastic coiled materials, which are close to each other, the side ends of the positioning rings are fixedly connected with a pair of side lugs, a pair of mounting grooves are formed in one ends of the pair of supports, which are close to each other, and the side lugs are in threaded connection with the mounting grooves through bolts.
Further, the inner circle diameter of arc board is greater than the outer lane diameter of inner tube, and the outer end fixedly connected with of arc board runs through its inside inlet pipe, and the outer end screw thread connection of inlet pipe has the main pipe lid, and the inner circle diameter of shrouding is the same with the outer lane diameter of inner tube, has seted up on the shrouding and has derived the passageway, the outer end fixedly connected with of shrouding with derive the communicating discharging pipe of passageway, the outer end screw thread connection of discharging pipe has vice tube cap.
Further, set up annular gas filtering passageway on the holding ring, the inside fixedly connected with waterproof ventilated membrane and a pair of arc otter board of annular gas filtering passageway, waterproof ventilated membrane fixed connection is between a pair of arc otter board, and annular gas filtering passageway is located between waterproof elastic coiled material and the inner tube, and waterproof elastic coiled material's surface fixedly connected with a plurality of evenly distributed's magnetic conduction stick, the outward appearance top of inner tube is equipped with main magnetism coating.
Further, the inside sliding connection of flash passageway has the overflow-blocking plate, and the upper and lower both ends of overflow-blocking plate extend to the upper and lower both sides of flash passageway respectively, and the transverse width of overflow-blocking plate up end is greater than the transverse width of flash passageway drill way, and overflow-blocking plate is located between fixed rotating plate and the movable rotating plate, and movable rotating plate is close to the fixed annular that has seted up with overflow-blocking plate assorted that rotates one end of board, and annular and overflow-blocking plate are close to the terminal surface and all scribble vice magnetic coating, and the arc-shaped groove with overflow-blocking plate upper end assorted has been seted up to the internal surface of shrouding.
Optionally, the support is provided with a circular groove, the circular groove on the support with the motor is fixedly connected with one end of the inner cylinder, and the other end of the inner cylinder is arranged in the circular groove of the support without the motor.
Compared with the prior art, the application has the advantages that:
(1) According to the application, the mixed carrageenan consisting of iota type and v type is used as a raw material to prepare the gel composition, so that the viscosity and the gel temperature of the gelatin solution of the gel composition can be reduced, the gel composition is relatively close to a gelatin system, and the gel composition can be produced by using capsule equipment based on the gelatin system, so that the equipment cost of the plant-based soft capsule is reduced.
(2) The gel composition is prepared by adopting the double-effect preparation device formed by combining the material mixing inner tank and the defoaming outer tank, so that the gel composition has the dual functions of mixing raw materials and defoaming simultaneously, on one hand, the raw materials are mixed in the material mixing inner tank, on the other hand, after the raw materials are mixed to obtain a composition primary product, the raw composition primary product is extruded by the inside of the material mixing inner tank automatically to enable the raw composition primary product to flow downwards along the outer wall of the material mixing inner tank in a sparse and shallow state, bubbles in the raw composition primary product are exposed, compression defoaming is realized in the process of diversion by combining with extrusion of the defoaming outer tank, and the gel composition is obtained.
(3) Through the dismantlement connected mode between inner tube and one of them support, can realize mixing the dismantlement between material inner tank and the defoaming outer tank, make things convenient for the washing of inner tube and defoaming outer tank.
Drawings
FIG. 1 is a diagram of the raw material composition of the present application;
FIG. 2 is a graph of the preparation process parameters of the mixed carrageenan samples of the present application;
FIG. 3 is a graph of index parameters of a sample of mixed carrageenan of the present application;
FIG. 4 is a graph of experimental design parameters of the present application;
FIG. 5 is a graph showing the results of the gum solution viscosity and the gel temperature of the gel composition obtained by the test of the present application;
fig. 6 is a perspective view of the dual purpose preparation apparatus of example 2 of the present application;
fig. 7 is a schematic side view of the dual purpose preparation apparatus of example 2 of the present application;
fig. 8 is a second perspective view of the dual purpose preparation apparatus of example 2 of the present application;
fig. 9 is a perspective view of the dual purpose preparation apparatus of example 2 of the present application when not installed;
FIG. 10 is a schematic side view of the dual purpose preparation apparatus of example 2 of the present application when stirring raw materials;
FIG. 11 is a schematic side view of the dual purpose preparation apparatus of example 2 of the present application in transferring the initial product of the composition;
fig. 12 is a perspective view of a dual purpose preparation vessel in example 2 of the present application;
FIG. 13 is a schematic view showing the front structure of the defoaming outer tank of example 2 of the present application when rotated 180 °;
fig. 14 is a schematic diagram showing the front structure of the dual-purpose preparation apparatus in example 2 of the present application when defoaming by compression;
fig. 15 is a perspective view of the dual effect preparation apparatus in example 2 of the present application in compression defoaming;
fig. 16 is a disassembled perspective view of embodiment 3 of the present application.
The reference numerals in the figures illustrate:
1 support, 2 inner cylinder, 201 flash passageway, 3 holding ring, 301 side ear, 302 arc otter board, 303 waterproof ventilated membrane, 4 shrouding, 401 export passageway, 5 waterproof elastic coiled material, 501 magnetic conduction stick, 6 arc board, 7 fixed rotating plate, 8 stirring rod, 9 moving rotating plate, 901 annular, 10 motor, 11 electric putter, 12 anti-overflow plate.
Detailed Description
The embodiments of the present application will be described in detail and fully with reference to the accompanying drawings, and it is intended that all other embodiments of the application, which are apparent to one skilled in the art without the inventive faculty, are included in the scope of the present application.
Example 1:
the application provides a gelling composition containing carrageenan, referring to fig. 1, the gelling composition comprises 100 parts of carrageenan powder, 20-60 parts of plasticizer and 100-200 parts of water, the carrageenan powder comprises mixed carrageenan and starch, 10-40 parts of mixed carrageenan comprises 60-90 parts of starch, the mixed carrageenan comprises iota-type carrageenan and v-type carrageenan, 65-90 parts of iota-type carrageenan comprises mixed carrageenan, 10-35 parts of v-type carrageenan comprises mixed carrageenan, and 15-45g/cm of gel strength of the mixed carrageenan 2 The optimization interval is 20-40/cm 2 The starch is at least one of acid treated starch or hydroxypropyl starch, and the plasticizer is at least one of glycerol or sorbitol.
The application also comprises a buffer salt, wherein the buffer salt adopts at least one of citrate, phosphate, dihydrogen phosphate or dibasic phosphate, and the buffer salt is 0-40% of the mixed carrageenan by weight.
The iota-type carrageenan which is commercially produced at present is mainly produced by taking red algae such as eucheuma spinosum and the like as raw materials, wherein the red algae contains partial v-type carrageenan which is a biological precursor substance of the iota-type carrageenan, and the iota-type carrageenan contains 6-position sulfate groups on beta- (1- & gt 4) linked galactopyranosyl groups, and is easy to form kinks on a high polymer chain to influence the formation of gel, so that the gel performance is not achieved; the beta- (1- & gt 4) -D-galactopyranosyl forms a 3, 6-endo ether bridge by alkali treatment or enzyme catalysis, so that v-carrageenan without gel property is converted into iota-carrageenan with gel property.
Therefore, when the iota-type carrageenan is produced by using the eucheuma spinosum or the eucheuma spinosum, under the control of the conversion conditions (such as alkali concentration, conversion temperature, conversion time and the like), only part of the v-type carrageenan is converted into the iota-type carrageenan, and part of the v-type carrageenan is reserved, so that the iota/v-type mixed carrageenan can be obtained. The carrageenan is used for preparing the gel composition, so that the viscosity and the gel temperature of the gelatin solution can be reduced, the gelatin composition is relatively close to a gelatin system, and the carrageenan is more suitable for gelatin system capsule equipment, thereby reducing the equipment cost of the plant-based soft capsule.
The application takes eucheuma spinosum as a raw material, and under different transformation conditions (alkali concentration, transformation temperature, transformation time and the like), a No. 1-8 mixed carrageenan sample is obtained.
Wherein the sample preparation parameters are shown in figure 2, and the sample index parameters are shown in figure 3.
The mixed carrageenan samples are respectively tested to prepare a gelling composition, and the preparation method comprises the following steps: according to the formula, the rubber powder, the plasticizer, the buffer salt and the water are weighed, the materials are put into a dissolving tank, and are stirred and dissolved at 70-98 ℃ and then defoamed to obtain a gelatinizing composition; and gelatin was used as sample 9 for a control test, see fig. 4 for specific test design parameters and fig. 5 for test results (the above test is only a preferred embodiment of the present application and is not intended to limit the application, and other test condition parameters may be selected by those skilled in the art).
According to the test results, the obtained iota/v mixed carrageenan can be used as a raw material under the control of conversion conditions (such as alkali concentration, conversion temperature, conversion time and the like), the viscosity of the gelatin solution can be controlled to be 30,000-80,000 mPa.s, the gel temperature is controlled to be 50-70 ℃, the melting temperature is controlled to be 60-80 ℃, the viscosity and the gel temperature of the gelatin solution are obviously improved compared with those of conventional commercial carrageenan, the gelatin system is more similar to that of a gelatin system, and the gelatin system is more suitable for capsule equipment of the gelatin system, so that the equipment cost of plant-based soft capsules is reduced.
Example 2:
on the basis of the embodiment 1, the embodiment also comprises a preparation method of the gel composition containing carrageenan, which is prepared by adopting a double-effect preparation device comprising an inner mixing tank and an outer defoaming tank, wherein the outer defoaming tank is sleeved on the outer side of the inner mixing tank, and specifically comprises the following steps:
s1, feeding: adjusting the position of the defoaming outer tank to enable the inner tank and the defoaming outer tank to be in a communicated state, opening a feeding pipe on the upper side of the defoaming outer tank, and sequentially adding rubber powder, plasticizer and water into the inner tank according to a proportion (shown in fig. 6 and 7);
s2, preliminary inversion and mixing: as shown in fig. 8 and 10, the defoaming outer tank is rotated 180 degrees, so that the material mixing inner tank and the defoaming outer tank are not communicated with each other, and raw materials in the material mixing inner tank are stirred, dissolved and mixed in an environment of 70-98 ℃ to obtain a composition primary product;
s3, performing secondary inversion and defoaming: the defoaming outer tank is rotated for 180 degrees again, the material mixing inner tank is communicated with the defoaming outer tank again, the initial product of the composition flows downwards along the outer wall of the material mixing inner tank in a sparse and shallow state by self-extrusion in the material mixing inner tank, bubbles in the initial product of the composition are exposed, compression defoaming is realized in the shunting process by combining extrusion of the defoaming outer tank (as shown in fig. 11 and 14-15);
s4, discharging: the prepared gelled composition was collected by opening the discharge pipe on the lower side of the defoaming outer tank.
Compared with the prior art, the preparation method of firstly mixing and then transferring to the defoaming equipment, the preparation process is carried out by adopting the double-effect preparation device, so that the preparation efficiency of the gel composition can be effectively improved, and the material transferring time and cost are saved.
Referring to fig. 9 and 10, the stirring inner tank includes an inner cylinder 2 with two ends connected with a support 1, in this embodiment, a flash channel 201 is formed at the upper end of the inner cylinder 2, a fixed rotating plate 7 and a movable rotating plate 9 are rotatably connected in the inner cylinder 2, one end of the fixed rotating plate 7 close to the movable rotating plate 9 is fixedly connected with a plurality of uniformly distributed stirring rods 8, the stirring rods 8 penetrate the movable rotating plate 9 and are slidably connected in the stirring rods, on one hand, a surface contact sealing state is formed between the stirring rods 8 and the movable rotating plate 9, so that raw materials can be stored between the fixed rotating plate 7 and the movable rotating plate 9, the stirring rods 8 and the movable rotating plate 9 are driven to rotate by the fixed rotating plate 7, stirring and mixing effects of the raw materials are achieved, on the other hand, after the raw materials are mixed, the movable rotating plate 9 can horizontally move along the stirring rods 8, the composition primary product is extruded, namely, the self-extrusion process in step S3 is achieved, the composition primary product is transferred from bottom to the outer tank through the flash channel 201, and the defoaming is compressed.
Referring to fig. 10, the outer end of the support 1 close to the fixed rotating plate 7 is fixedly connected with a motor 10, the output end of the motor 10 movably penetrates through the support 1 and the inner cylinder 2 and is fixedly connected with the outer end of the fixed rotating plate 7, the inner wall of the inner cylinder 2 far away from the fixed rotating plate 7 is fixedly connected with an electric push rod 11, the telescopic end of the electric push rod 11 is fixedly connected with a T-shaped rotating shaft, the T-shaped rotating shaft is rotatably connected with one end of the movable rotating plate 9 far away from the fixed rotating plate 7, the fixed rotating plate 7 is driven to rotate by the motor 10, the stirring effect of the stirring rod 8 on raw materials is achieved, after stirring is completed, the movable rotating plate 9 is pushed to approach the fixed rotating plate 7 by extending through the electric push rod 11, a composition primary product is extruded into a defoaming outer tank through a flash channel 201, and the setting of the T-shaped rotating shaft is not easy to block the rotation of the movable rotating plate 9 while the movable rotating plate 9 is connected with the electric push rod 11.
Referring to fig. 9, the defoaming outer tank includes a pair of positioning rings 3 sleeved at the outer end of the inner cylinder 2, a sealing plate 4, an arc plate 6 and a pair of waterproof elastic coiled materials 5 are fixedly connected between the pair of positioning rings 3, the sealing plate 4 and the arc plate 6 are respectively and fixedly connected between two ends of the pair of waterproof elastic coiled materials 5, the waterproof elastic coiled materials 5 can adopt waterproof elastic cloth to realize the compression defoaming effect on the primary product of the composition through elasticity of the waterproof elastic coiled materials, a pair of side lugs 301 are fixedly connected at the side ends of the positioning rings 3, a pair of mounting grooves are formed at one ends of the pair of supports 1, which are close to each other, the side lugs 301 are connected with the mounting grooves through screw threads, the diameter of the inner ring of the positioning rings 3 is identical with the diameter of the outer ring of the inner cylinder 2, so that the rotation at the outer end of the inner cylinder 2 is conveniently realized, and the pair of side lugs 301 are symmetrical with each other about the vertical plane where the center line of the positioning rings 3 is located, and the positioning of the defoaming outer tank is realized after 180 degrees of rotation through the connection of the side lugs 301 and the mounting grooves.
Referring to fig. 6 and 7, the diameter of the inner ring of the arc plate 6 is larger than the diameter of the outer ring of the inner cylinder 2, the outer end of the arc plate 6 is fixedly connected with a feeding pipe penetrating through the inner ring, the outer end of the feeding pipe is in threaded connection with a main pipe cover, the arc plate 6 is positioned on the upper side of the flash channel 201 through rotating the positioning ring 3, the sealing plate 4 is positioned on the lower side of the inner cylinder 2, namely, the stirring inner tank and the defoaming outer tank in the step S1 are in a communicating state, as shown in fig. 7, at the moment, a feeding pipe simultaneously applicable to the feeding pipe and the flash channel 201 can be adopted, the feeding pipe and the flash channel 201 penetrate through the feeding pipe and the flash channel 201 until the feeding pipe stretches into the support 1, raw materials are fed into the inner cylinder 2 and stored between the fixed rotating plate 7 and the movable rotating plate 9.
Referring to fig. 9 and fig. 10, the diameter of the inner ring of the sealing plate 4 is the same as the diameter of the outer ring of the inner cylinder 2, the sealing plate 4 is positioned on the right upper side of the flash channel 201 by rotating the positioning ring 3, that is, the inner tank for mixing materials and the outer tank for defoaming are not communicated in the step S2, at this time, the sealing plate 4 has a sealing effect on the flash channel 201, so that raw materials can be conveniently mixed in the inner cylinder 2, and in combination with fig. 12 and fig. 14, a guiding-out channel 401 is formed on the sealing plate 4, the outer end of the sealing plate 4 is fixedly connected with a discharging pipe communicated with the guiding-out channel 401, and the outer end of the discharging pipe is in threaded connection with an auxiliary pipe cover, so that the final gelled composition can be conveniently discharged and collected through the guiding-out channel 401 and the discharging pipe.
Referring to fig. 11 and 12, an annular air filtering channel is formed on the positioning ring 3, a waterproof and air permeable membrane 303 and a pair of arc-shaped mesh plates 302 are fixedly connected to the inside of the annular air filtering channel, the waterproof and air permeable membrane 303 is fixedly connected between the pair of arc-shaped mesh plates 302, the annular air filtering channel is located between the waterproof elastic coiled material 5 and the inner cylinder 2, a plurality of uniformly distributed magnetic conductive rods 501 are fixedly connected to the outer surface of the waterproof elastic coiled material 5, a main magnetic coating is coated on the outer surface of the inner cylinder 2, and due to the magnetic attraction between the magnetic conductive rods 501 and the main magnetic coating, the waterproof elastic coiled material 5 is in a state of being attached to the outer surface of the inner cylinder 2 in a large area as shown in fig. 13, in step S3, by controlling the moving speed of the rotating plate 9, a composition primary product quickly overflows the flash channel 201 as shown in fig. 14, then, air bubbles inside the primary product are exposed out in a sparse and thin state, and then combined with the magnetic attraction effect, the elastic coiled material 5 has a trend of approaching to the inner cylinder 2, so that the waterproof coiled material 5 can crack on the primary product, and the air bubbles can flow out through the arc-shaped mesh plates, and the foam can be dispersed to the outside, thereby realize the effect of the foam-free air permeable membrane 303. Supplementary explanation: as shown in fig. 15, by the arrangement that the thickness of the side ear 301 is greater than that of the positioning ring 3, after the side ear 301 is fixed to the support 1, a gap exists between the positioning ring 3 and the support 1, so that gas overflows.
Referring to fig. 9 and 10, the overflow preventing plate 12 is slidably connected in the overflow preventing channel 201, the upper and lower ends of the overflow preventing plate 12 extend to the upper and lower sides of the overflow preventing channel 201 respectively, the transverse width of the upper end face of the overflow preventing plate 12 is larger than the transverse width of the orifice of the overflow preventing channel 201, the limit function is achieved, the annular groove 901 matched with the overflow preventing plate 12 is formed in one end of the movable rotating plate 9 close to the fixed rotating plate 7, and the auxiliary magnetic coating is coated on the end faces of the annular groove 901 and the end face of the overflow preventing plate 12 close to each other.
When the movable rotating plate 9 does not move, the overflow preventing plate 12 is positioned between the fixed rotating plate 7 and the movable rotating plate 9, the overflow preventing plate 12 is not easy to block the rotation of the movable rotating plate 9, when the overflow preventing plate 12 is started to push the movable rotating plate 9 to move, as shown in fig. 11, when the movable rotating plate 9 moves to the overflow preventing plate 12, the overflow preventing plate 12 can enter the annular groove 901, on one hand, the function of obviously separating the inner space of the overflow channel 201 is achieved through the arrangement of the overflow preventing plate 12, so that overflowed primary products of the composition smoothly flow down along the two outer sides of the inner cylinder 2, are not easy to flow into the other side (namely the space where the electric push rod 11 is positioned) of the inner cylinder 2 beyond the upper end of the movable rotating plate 9, on the other hand, the movable rotating plate 9 can move to be in a fit state with the fixed rotating plate 7 through the annular groove 901, contact blocking between the movable rotating plate 9 and the fixed rotating plate 7 is not easy to be blocked, the primary products of the composition can be extruded into the waterproof elastic coiled material 5 approximately completely, on the other hand, when the movable rotating plate 9 moves back to the original position, the magnetic plate 12 with the auxiliary magnetic coating is moved back to the original position, the magnetic plate 12 can be used for sealing the arc-shaped sealing plate 12, and the arc-shaped sealing plate 12 can be matched with the arc-shaped sealing plate 12.
Example 3:
in comparison with embodiment 2, in this embodiment, the inner cylinder 2 is detachably connected to one of the supports 1, the other is fixedly connected, and the other structure is identical to that of embodiment 2, and is specifically set as follows: referring to fig. 16, a circular groove is formed in the support 1, the circular groove on the support 1 with the motor 10 is fixedly connected with one end of the inner cylinder 2, and the other end of the inner cylinder 2 is placed in the circular groove of the support 1 without the motor 10.
Through the setting of above-mentioned connected mode for one of them support 1 can be dismantled from the one end of inner tube 2, and then realize dismantling between inner tube 2 and the support 1, with this washing that can make things convenient for inner tube 2 and defoaming outer tank, when the installation, embolia defoaming outer tank from the one end of inner tube 2 earlier, then place this tip of inner tube 2 in the circular slot of support 1, the rethread bolt is fixed with the mounting groove on support 1, fix the position of a pair of support 1 through defoaming outer tank, thereby realize the fixed of support 1 and inner tube 2, in addition, after dismantling defoaming outer tank, can directly add the raw materials to inner tube 2 through flash passageway 201, compare the charging mode of embodiment 2 more convenient, after the raw materials is added and is accomplished, carry out the installation of defoaming outer tank again.
The foregoing is merely illustrative of the best modes of carrying out the application in connection with the actual requirements, and the scope of the application is not limited thereto.
Claims (2)
1. The utility model provides a double-effect preparation ware for containing cementing composition of carrageenan, its characterized in that includes mixing material inner tank and defoaming outer jar, mix material inner tank including inner tube (2) that both ends all are connected with support (1), flash passageway (201) have been seted up to the upper end of inner tube (2), the inside rotation of inner tube (2) is connected with fixed rotating plate (7) and moves rotating plate (9), the one end that is close to moving rotating plate (9) of fixed rotating plate (7) fixedly connected with a plurality of evenly distributed's stirring rod (8), stirring rod (8) run through moving rotating plate (9) and sliding connection in its inside, be close to the outer end fixedly connected with motor (10) of support (1) of fixed rotating plate (7), the output activity of motor (10) runs through support (1) and inner tube (2) and is fixedly connected with the outer end of fixed rotating plate (7), the inner wall that inner tube (2) kept away from fixed rotating plate (7) is fixedly connected with electric putter (11), electric putter (11) are fixed rotating plate (7) are kept away from in a fixed connection of rotating shaft T type pivot (7);
the defoaming outer tank comprises a pair of positioning rings (3) sleeved at the outer end of an inner cylinder (2), a sealing plate (4), an arc plate (6) and a pair of waterproof elastic coiled materials (5) are fixedly connected between the positioning rings (3), the sealing plate (4) and the arc plate (6) are respectively and fixedly connected between two ends of the pair of waterproof elastic coiled materials (5) which are close to each other, a pair of side lugs (301) are fixedly connected to the side ends of the positioning rings (3), a pair of mounting grooves are formed in one ends of the support (1) which are close to each other, and the side lugs (301) are connected with the mounting grooves through screw threads;
the diameter of the inner ring of the arc plate (6) is larger than that of the outer ring of the inner cylinder (2), the outer end of the arc plate (6) is fixedly connected with a feeding pipe penetrating through the inner ring, the outer end of the feeding pipe is in threaded connection with a main pipe cover, the diameter of the inner ring of the sealing plate (4) is the same as that of the outer ring of the inner cylinder (2), a guide-out channel (401) is formed in the sealing plate (4), the outer end of the sealing plate (4) is fixedly connected with a discharging pipe communicated with the guide-out channel (401), and the outer end of the discharging pipe is in threaded connection with a secondary pipe cover;
an annular air filtering channel is formed in the positioning ring (3), a waterproof breathable film (303) and a pair of arc-shaped mesh plates (302) are fixedly connected to the inside of the annular air filtering channel, the waterproof breathable film (303) is fixedly connected between the pair of arc-shaped mesh plates (302), the annular air filtering channel is located between the waterproof elastic coiled material (5) and the inner cylinder (2), a plurality of uniformly distributed magnetic conductive rods (501) are fixedly connected to the outer surface of the waterproof elastic coiled material (5), and a main magnetic coating is coated on the outer surface of the inner cylinder (2);
the inside sliding connection of flash passageway (201) has and hinders spillover board (12), the upper and lower both ends that hinder spillover board (12) extend to the upper and lower both sides of flash passageway (201) respectively, the lateral width that hinders spillover board (12) up end is greater than the lateral width of flash passageway (201) drill way, it is located between fixed rotating plate (7) and movable rotating plate (9) to hinder spillover board (12), movable rotating plate (9) are close to fixed rotating plate (7) one end seted up with hinder spillover board (12) assorted annular (901), annular (901) and the terminal surface that hinders spillover board (12) looks are all scribbled vice magnetic coating, arc-shaped groove with hinder spillover board (12) upper end assorted is seted up to the internal surface of shrouding (4).
2. The double-effect preparation device for the carrageenan-containing gel composition according to claim 1, wherein the support (1) is provided with a round groove, the round groove on the support (1) with the motor (10) is fixedly connected with one end of the inner cylinder (2), and the other end of the inner cylinder (2) is arranged in the round groove of the support (1) without the motor (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310547487.4A CN116531343B (en) | 2023-05-16 | 2023-05-16 | Gelling composition containing carrageenan and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310547487.4A CN116531343B (en) | 2023-05-16 | 2023-05-16 | Gelling composition containing carrageenan and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116531343A CN116531343A (en) | 2023-08-04 |
| CN116531343B true CN116531343B (en) | 2023-12-01 |
Family
ID=87445011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310547487.4A Active CN116531343B (en) | 2023-05-16 | 2023-05-16 | Gelling composition containing carrageenan and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116531343B (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310725A (en) * | 1998-07-30 | 2001-08-29 | 赫尔克里士公司 | Carrangeenan compositions, and processes for their production |
| EP1598062A1 (en) * | 1999-07-07 | 2005-11-23 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
| JP2013132590A (en) * | 2011-12-26 | 2013-07-08 | Sharp Corp | Stirring container, stirring defoaming device including the same, and sealing resin material produced by the same |
| CN103228269A (en) * | 2010-08-04 | 2013-07-31 | R·P·舍勒科技有限责任公司 | Film-forming composition for soft capsules |
| CN106038508A (en) * | 2016-06-17 | 2016-10-26 | 上海春芝堂生物制品有限公司 | Plant capsule shell material, soft capsules, and preparation method and application of plant capsule shell material and soft capsule |
| CN107106507A (en) * | 2014-10-03 | 2017-08-29 | 富士胶囊有限公司 | Soft capsule envelope |
| CN113322184A (en) * | 2021-06-08 | 2021-08-31 | 李东荣 | Torrent type bioreactor for cell culture |
| CN115122486A (en) * | 2022-08-01 | 2022-09-30 | 衡阳凯新特种材料科技有限公司 | Ceramic gel injection molding device and injection molding method |
| CN217961399U (en) * | 2022-07-29 | 2022-12-06 | 苏州磁亿电子科技有限公司 | Defoaming jar |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11560439B2 (en) * | 2020-04-24 | 2023-01-24 | Hunan Er-Kang Pharmaceutical Co., Ltd. | Hydroxypropyl starch for preparing empty capsules and hydroxypropyl starch-based soft capsules |
-
2023
- 2023-05-16 CN CN202310547487.4A patent/CN116531343B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1310725A (en) * | 1998-07-30 | 2001-08-29 | 赫尔克里士公司 | Carrangeenan compositions, and processes for their production |
| EP1598062A1 (en) * | 1999-07-07 | 2005-11-23 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
| CN103228269A (en) * | 2010-08-04 | 2013-07-31 | R·P·舍勒科技有限责任公司 | Film-forming composition for soft capsules |
| JP2013132590A (en) * | 2011-12-26 | 2013-07-08 | Sharp Corp | Stirring container, stirring defoaming device including the same, and sealing resin material produced by the same |
| CN107106507A (en) * | 2014-10-03 | 2017-08-29 | 富士胶囊有限公司 | Soft capsule envelope |
| CN106038508A (en) * | 2016-06-17 | 2016-10-26 | 上海春芝堂生物制品有限公司 | Plant capsule shell material, soft capsules, and preparation method and application of plant capsule shell material and soft capsule |
| CN113322184A (en) * | 2021-06-08 | 2021-08-31 | 李东荣 | Torrent type bioreactor for cell culture |
| CN217961399U (en) * | 2022-07-29 | 2022-12-06 | 苏州磁亿电子科技有限公司 | Defoaming jar |
| CN115122486A (en) * | 2022-08-01 | 2022-09-30 | 衡阳凯新特种材料科技有限公司 | Ceramic gel injection molding device and injection molding method |
Non-Patent Citations (1)
| Title |
|---|
| 刺麒麟菜基本成分分析和 ι-卡拉胶的提取工艺参数优化;朱敏;研究报告;第35卷;1-5 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116531343A (en) | 2023-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107739556B (en) | A kind of preparation method of high-molecular anti-bacteria coating | |
| CN116531343B (en) | Gelling composition containing carrageenan and preparation method thereof | |
| WO2015027552A1 (en) | Industrial defoaming method for high-viscosity pure chitosan spinning solution | |
| CN105330875B (en) | A kind of cross-linking modified sodium alginate and preparation method thereof | |
| CN210796453U (en) | Marsh gas fermentation device beneficial to slag discharge | |
| CN103834044A (en) | Method for quickly dissolving sodium carboxymethylcellulose applied to battery paste | |
| CN105968931A (en) | Preparation method of interior wall waterproof putty paste | |
| CN212174846U (en) | Washing device for separating byproduct ammonium chloride in NBPT production | |
| CN206138836U (en) | Hybrid processing device that combined material system filtration membrane used | |
| CN101604741A (en) | A kind of water-base anode formula of lithium iron phosphate dynamic battery and preparation method | |
| US20230383223A1 (en) | Bioculture Meat Device | |
| CN205965710U (en) | Lubricating oil blending kettle | |
| CN102106519B (en) | Method for swelling konjaku | |
| CN205269670U (en) | Reaction kettle | |
| CN206014732U (en) | A kind of de- ethanol washing bed apparatus of ethyl acetate | |
| CN207605729U (en) | A kind of reaction kettle for producing liquid fertilizer | |
| CN203955120U (en) | A kind of gel agitator | |
| CN207655141U (en) | A kind of Double shaft stirring reaction unit for pesticide producing | |
| CN211725671U (en) | Modified asphalt production system | |
| CN215277327U (en) | Suspension liquid fertilizer circulation reation kettle | |
| CN205903894U (en) | Zinc stearate reactor | |
| CN205813426U (en) | A kind of flour mixer | |
| CN110742197A (en) | Nutritional feed for dairy cow breeding | |
| CN219603565U (en) | Anti-pollution lactobacillus fermentation culture tank | |
| CN218688612U (en) | Binding agent adding device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |