CN116531139A - Rat pituitary aspiration system - Google Patents
Rat pituitary aspiration system Download PDFInfo
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- CN116531139A CN116531139A CN202310822602.4A CN202310822602A CN116531139A CN 116531139 A CN116531139 A CN 116531139A CN 202310822602 A CN202310822602 A CN 202310822602A CN 116531139 A CN116531139 A CN 116531139A
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- ear
- deformation
- extension tube
- conduit
- pituitary
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- 230000001817 pituitary effect Effects 0.000 title claims abstract description 37
- 230000007246 mechanism Effects 0.000 claims abstract description 129
- 229910000831 Steel Inorganic materials 0.000 claims abstract description 57
- 239000010959 steel Substances 0.000 claims abstract description 57
- 230000000149 penetrating effect Effects 0.000 claims abstract description 14
- 238000001179 sorption measurement Methods 0.000 claims abstract description 6
- 238000005452 bending Methods 0.000 claims description 61
- 238000004891 communication Methods 0.000 claims description 16
- 241000700159 Rattus Species 0.000 abstract description 44
- 206010062767 Hypophysitis Diseases 0.000 abstract description 30
- 210000003635 pituitary gland Anatomy 0.000 abstract description 30
- 238000012925 biological evaluation Methods 0.000 abstract description 4
- 238000010171 animal model Methods 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 abstract 1
- 210000003128 head Anatomy 0.000 description 16
- 210000004556 brain Anatomy 0.000 description 14
- 238000000034 method Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- 210000003454 tympanic membrane Anatomy 0.000 description 9
- 230000008569 process Effects 0.000 description 6
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endoscopes (AREA)
Abstract
The invention relates to a rat pituitary suction system, which comprises a head fixing device, a pituitary suction mechanism and a camera shooting mechanism; the head fixing device comprises a mouth fixing mechanism and two ear fixing mechanisms; the pituitary adsorption mechanism comprises a conduit mechanism and a negative pressure device, the conduit mechanism comprises an adjustable bent steel pipe and a conduit, the conduit is a deformable hose, and the conduit is arranged in the adjustable bent steel pipe in a penetrating way; the tail end of the conduit is also connected with a negative pressure device; the camera shooting mechanism comprises an extension tube, a camera and a display device, the camera is arranged at the far end of the extension tube, a wire of the camera penetrates through the extension tube and penetrates out from the tail end of the extension tube, and the wire is connected with the display device. Can visually remove pituitary gland, ensure that the pituitary gland can be accurately removed, reduce the death rate of rats subjected to pituitary gland removal operation, and provide a stable animal model for subsequent biological evaluation experiments.
Description
Technical Field
The invention relates to the field of biological tests, in particular to a rat pituitary aspiration system.
Background
In the biological evaluation of growth hormone drugs, the hormone is required to act on rats, then the growth state of the rats is observed, and pituitary glands of the rats are required to be removed before the hormone acts on the rats so as to prevent the influence of the hormone of the rats on the test.
The prior art method for taking out the pituitary gland of the rat comprises the steps of firstly anaesthetizing and fixing the rat, then using a needle head to puncture the eardrum from the ear position of the rat, extending into the pituitary gland position, and sucking away the pituitary gland to achieve the aim of removing the pituitary gland.
In the process, the needle is extended to the pituitary position, usually by the experience of operators, so that more brain tissues except the pituitary of the rat are sucked, and the death of the rat is caused; or incomplete pituitary removal, resulting in failure of model establishment. In order to ensure the subsequent drug evaluation test, the traditional method increases the number of modeling animals, so that the animal consumption is large, and the labor cost is further increased.
Disclosure of Invention
In view of the above, the invention provides a rat pituitary aspiration system, which can visually remove pituitary, ensure that pituitary can be removed accurately and completely, prevent death of rats in the pituitary removal process, provide a reliable animal model for subsequent biological evaluation tests, and reduce test cost.
The invention adopts the technical scheme that:
a rat pituitary suction system, which comprises a head fixing device, a pituitary suction mechanism and a camera shooting mechanism;
the head fixing device comprises a mouth fixing mechanism and two ear fixing mechanisms, wherein the two ear fixing mechanisms are a first ear fixing mechanism and a second ear fixing mechanism respectively, the first ear fixing mechanism and the second ear fixing mechanism are oppositely arranged left and right and can slide in the up-down direction and the left-right direction, and the mouth fixing mechanism is positioned at the front sides of the two ear fixing mechanisms and is positioned at the middle position of the two ear fixing mechanisms;
the ear fixing mechanism comprises a first moving track, a second moving track, a moving arm and an ear rod, wherein the first moving track extends along the vertical direction, the second moving track extends along the left-right direction, the moving arm is slidably mounted on the second moving track, the second moving track is mounted on the first moving track, the ear rod is rotatably connected with the moving arm, the rotating direction of the ear rod is the front-back direction, an axially-through communication channel is arranged in the ear rod, the far end of the ear rod of the first ear fixing mechanism faces the second ear fixing mechanism, the far end of the ear rod of the second ear fixing mechanism faces the first ear fixing mechanism, and in the left-right direction, the two ear rods are oppositely arranged;
the pituitary adsorption mechanism comprises a conduit mechanism and a negative pressure device, the conduit mechanism comprises an adjustable bent steel pipe and a conduit, the conduit is a deformable hose, the conduit is arranged in the adjustable bent steel pipe in a penetrating way, and the far end of the conduit mechanism is used for penetrating through a communication channel of the ear rod and penetrating out of the far end of the ear rod; the tail end of the conduit is also connected with the negative pressure device;
the camera shooting mechanism comprises an extension tube, a camera and a display device, the camera is arranged at the far end of the extension tube, a wire of the camera passes through the extension tube and passes out from the tail end of the extension tube, and the wire is connected with the display device; the distal end of the extension tube is configured to pass through the communication channel and out the distal end of the ear stem.
Preferably, the adjustable bending steel pipe comprises a steel pipe body and a bending control wire connected with the steel pipe body, wherein the steel pipe body comprises a straight pipe section and a bent pipe section which are connected with each other, and the bent pipe section is positioned at the far end side of the straight pipe section; the bending pipe section is provided with a plurality of deformation openings penetrating through the single-side wall of the bending pipe section, the deformation openings extend to two sides along the circumferential direction of the bending pipe section, and the deformation openings are arranged at intervals along the axial direction of the bending pipe section;
the deformation openings are divided into a first deformation opening group, a second deformation opening group, a third deformation opening group and a fourth deformation opening group, and the positions of the deformation openings in the deformation opening groups in the circumferential direction are consistent; in the circumferential direction, the first deformation mouth group, the second deformation mouth group, the third deformation mouth group and the fourth deformation mouth group are sequentially staggered by 90 degrees along the clockwise direction;
the distal end of the bending control wire is connected to the distal end side of the bending pipe section and extends out of the tail end of the steel pipe body from the inside of the steel pipe body;
the far end of the steel pipe body is in a needle shape;
the guide pipe penetrates through the steel pipe body, the far end of the guide pipe is leveled with and connected with the far end of the steel pipe body, the tail end of the guide pipe penetrates out of the tail end of the steel pipe body, and the bending control wire is located on the outer side of the guide pipe.
Preferably, the length of the straight pipe section is 40-60mm, and the length of the bent pipe section is 10-20mm.
Preferably, the number of the bending control wires is four, namely a first bending control wire, a second bending control wire, a third bending control wire and a fourth bending control wire, wherein the first bending control wire corresponds to the first deformation port group, the second bending control wire corresponds to the second deformation port group, the third bending control wire corresponds to the third deformation port group, and the fourth bending control wire corresponds to the fourth deformation port group; in the corresponding bending control wire and deformation port group, the bending control wire and the deformation port group are positioned on the same side of the bending pipe section.
Preferably, the camera shooting mechanism further comprises an LED illuminating lamp, the LED illuminating lamp and the camera are installed at the far end of the extension tube side by side, and a lead of the LED illuminating lamp penetrates through the extension tube and penetrates out of the tail end of the extension tube.
Preferably, the extension tube is a straight tube, and the distal end thereof is needle-shaped.
Preferably, the distal end of the communication channel is provided with two complementary communication through holes, the distal end of the catheter mechanism passes out of one through hole, and the distal end of the extension tube passes out of the other through hole.
Preferably, the rotation angle of the ear lever is 12-18 °.
Preferably, the mouth fixing mechanism comprises a height sliding rail, a connecting frame, a fixed toothed plate and a pressing cap, wherein the height sliding rail is vertically arranged, the connecting frame is connected with the height sliding rail in a sliding manner, the pressing cap and the fixed toothed plate are both connected with the connecting frame, the pressing cap is positioned on the upper side of the fixed toothed plate, an adjusting screw is arranged between the pressing cap and the fixed toothed plate, and the adjusting screw penetrates through the pressing cap to be in threaded connection with the fixed toothed plate so as to adjust the interval between the pressing cap and the fixed toothed plate;
and the tooth fixing plate is provided with a tooth clamping opening.
Preferably, the press cap comprises a supporting block and an oval fixing ring, the fixing ring is connected with a net bag, the fixing ring is horizontally arranged, the fixing ring is connected with the supporting block, and the adjusting screw penetrates through the supporting block to be in threaded connection with the fixed toothed plate.
The invention has the beneficial effects that:
when the pituitary gland of the rat is removed, the mouth of the rat is fixed in the noble part fixing mechanism, the ear rods of the two ear fixing mechanisms are respectively inserted into the two ears of the rat, so that the whole head of the rat is fixed, the extension tube extends into the brain of the rat from one ear rod, the camera at the far end of the extension tube can shoot images in the brain of the rat and display the images through the display device, thus operators can see pictures in the brain of the rat in real time, then the catheter mechanism extends into the brain from the same ear rod, and the position of the catheter mechanism can be accurately controlled due to the fact that the pictures in the brain can be seen in real time, so that the distal end of the catheter mechanism is close to the pituitary gland, the pituitary gland can be accurately and efficiently removed, the effectiveness of a subsequent biological evaluation test and the accuracy of the result are ensured, and the cost of the subsequent test is reduced.
Drawings
The above and other objects, features and advantages of the present invention will become more apparent from the following description of embodiments of the present invention with reference to the accompanying drawings, in which:
FIG. 1 is a schematic structural view of a head restraint;
FIG. 2 is a cross-sectional view of the catheter mechanism;
fig. 3 is a schematic structural view of the steel pipe body;
FIG. 4 is a schematic view of the distal end of the extension tube;
fig. 5 is a schematic view of a catheter mechanism and extension tube passing through a communication channel.
Wherein: 1. a mouth fixing mechanism; 2. a first ear fixing mechanism; 3. a second ear fixing mechanism; 4. an ear stem; 5. a catheter mechanism;
11. a tooth fixing plate; 12. pressing the cap; 13. adjusting a screw; 111. a tooth clamping opening; 121. a fixing ring;
21. a first moving track; 22. a second moving rail;
51. a conduit; 52. a bendable steel pipe; 521. a straight pipe section; 522. a curved pipe section; 523. a deformation opening;
61. a camera; 62. an LED illuminating lamp.
Detailed Description
The present invention is described below based on examples, but the present invention is not limited to only these examples. In the following detailed description of the present invention, certain specific details are set forth in order to avoid obscuring the present invention, and in order to avoid obscuring the present invention, well-known methods, procedures, flows, and components are not presented in detail.
Moreover, those of ordinary skill in the art will appreciate that the drawings are provided herein for illustrative purposes and that the drawings are not necessarily drawn to scale.
Unless the context clearly requires otherwise, throughout the description and the claims, the words "comprise", "comprising", and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is, it is the meaning of "including but not limited to".
In the description of the present invention, it should be understood that the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. Furthermore, in the description of the present invention, unless otherwise indicated, the meaning of "a plurality" is two or more.
Based on the operation time, the side close to the patient is far, and the side close to the operator is near.
Referring to fig. 1-5, the present invention provides a rat pituitary aspiration system for removing pituitary glands from a rat, comprising a head fixation device, a pituitary suction mechanism, and a camera mechanism.
The head fixing device comprises a mouth fixing mechanism 1 and two ear fixing mechanisms, wherein the two ear fixing mechanisms are a first ear fixing mechanism 2 and a second ear fixing mechanism 3 respectively, the first ear fixing mechanism 2 and the second ear fixing mechanism 3 are oppositely arranged left and right and can slide in the vertical and horizontal directions, and the mouth fixing mechanism 1 is positioned at the front sides of the two ear fixing mechanisms and is positioned at the middle position of the two ear fixing mechanisms.
The ear fixing mechanism comprises a first moving track 21, a second moving track 22, a moving arm and an ear rod 4, wherein the first moving track 21 extends along the vertical direction, the second moving track 22 extends along the left-right direction, the moving arm is slidably mounted on the second moving track 22, and the second moving track 22 is mounted on the first moving track 21, so that the second moving track 22 and the moving arm thereon can slide along the first track in the up-down direction; the moving arm is slidably mounted on the second moving track 22, so that the moving arm can slide in a left-right direction, and thus the moving arm can slide freely in an up-down direction and a left-right direction, the ear rod 4 is rotatably connected to the moving arm, the rotation direction of the ear rod 4 is a front-back direction, an axially through communication channel is arranged in the ear rod 4, the distal end of the ear rod 4 of the first ear fixing mechanism 2 faces the second ear fixing mechanism 3, the distal end of the ear rod 4 of the second ear fixing mechanism 3 faces the first ear fixing mechanism 2, and the two ear rods 4 are oppositely arranged in the left-right direction.
The pituitary adsorption mechanism comprises a conduit mechanism 5 and a negative pressure device, the conduit mechanism 5 comprises a bendable steel pipe 52 and a conduit 51, the conduit 51 is a deformable hose, the conduit 51 is penetrated in the bendable steel pipe 52, and the distal end of the conduit mechanism 5 is used for penetrating through a communication channel of the ear rod 4 and penetrating out of the distal end of the ear rod 4; the tail end of the conduit 51 is also connected to the negative pressure device.
The camera shooting mechanism comprises an extension tube, a camera 61 and a display device, wherein the camera 61 is arranged at the far end of the extension tube, a wire of the camera 61 passes through the extension tube and passes out from the tail end of the extension tube, and the wire is connected with the display device; the distal end of the extension tube is adapted to pass through the communication channel and out the distal end of the ear stem 4.
When the pituitary gland of the rat is removed, the rat, in particular the head of the rat, is fixed by the head fixing device, specifically, the mouth fixing mechanism 1 can slide in the front-back direction, the first ear fixing mechanism 2 and the second ear fixing mechanism 3 can slide in the left-right direction, and the mouth fixing mechanism 1 is wholly positioned at the front sides of the two ear fixing mechanisms, so that the positions among the three mechanisms can be adjusted to adapt to rats with different sizes; when the head of a rat is fixed, the rat is anesthetized, then the teeth of the rat are clamped at the mouth fixing mechanism 1, the position of the mouth fixing mechanism 1 is adjusted in the front-back direction, so that the two ear fixing mechanisms are just positioned at the left and right sides of the ear of the rat respectively, then the first ear fixing mechanism 2 is correspondingly fixed with the left ear (for example, the first ear fixing mechanism 2 is positioned at the left and the second ear fixing mechanism 3 is positioned at the right), the second ear fixing mechanism 3 is correspondingly fixed with the right ear, the position of the ear fixing mechanism is adjusted in the left-right direction, the ear rod 4 on the first ear fixing mechanism 2 is inserted into the left ear, and the ear rod 4 of the second ear fixing mechanism 3 is inserted into the right ear, so that the fixing of the head of the rat is realized.
It should be noted that when the ear stem 4 is inserted into the ear, the distal end of the ear stem 4 (the end inserted into the ear) is substantially close to the eardrum, but does not puncture the eardrum.
Since the ear stem 4 has a hollow structure, and a communication channel is formed therein, when an image of the brain of a rat is acquired, the distal end of the extension tube is inserted from the tail end of the ear stem 4, along the communication channel, and out of the distal end of the ear stem 4, and then the ear drum is pierced, at this time, the distal end of the extension tube reaches the brain, and the camera 61 is mounted at the distal end of the extension tube, so that the image of the brain, particularly the pituitary, can be captured by the camera 61 and displayed by a display device, such as a display.
Finally, the pituitary gland is removed through a pituitary gland adsorption mechanism, specifically, the distal end of the catheter mechanism 5 penetrates from the same ear rod 4 (the ear rod 4 penetrated by the extension tube) and pierces through the eardrum, the distal end of the catheter mechanism 5 can reach the inside of the brain, at the moment, the image of the distal end of the catheter mechanism 5 can be observed through a display, the adjustable bent steel tube 52 is adjusted according to the position of the distal end of the catheter mechanism 5, so that the distal end of the catheter mechanism 5 is close to the pituitary gland, suction is generated through a negative pressure device, the pituitary gland is adsorbed through the distal end of the catheter 51 (also the distal end of the catheter mechanism 5), and the purpose of removing the pituitary gland is achieved, and the whole adsorption process can be displayed in real time through the display device, so that whether the pituitary gland is removed completely or not can be easily confirmed, and other tissues except the pituitary gland are prevented from being adsorbed, and the subsequent test is ensured to be smoothly carried out; after the pituitary gland is removed, the catheter mechanism 5 and the extension tube are withdrawn, and the rat is removed from the head fixing device.
The negative pressure device is a device capable of generating negative pressure, such as an air pump.
In the process, an operator can see the process of removing the pituitary gland in real time, and the catheter mechanism 5 can be controlled to bend, so that the pituitary gland can be removed accurately, the efficiency and the accuracy of the process are improved, and the follow-up test is convenient to carry out.
For the adjustable bend steel pipe 52, the adjustable bend steel pipe 52 comprises a steel pipe body and a bend control wire connected with the steel pipe body, the steel pipe body comprises a straight pipe section 521 and a bent pipe section 522 which are connected with each other, and the bent pipe section 522 is positioned on the far end side of the straight pipe section 521; the curved pipe section 522 is provided with a plurality of deformation openings 523 penetrating through a single-side wall of the curved pipe section 522, the deformation openings 523 extend to two sides along the circumferential direction of the curved pipe section 522, and the plurality of deformation openings 523 are arranged at intervals along the axial direction of the curved pipe section 522.
The deformation openings 523 are divided into a first deformation opening group, a second deformation opening group, a third deformation opening group and a fourth deformation opening group, and the positions of the deformation openings 523 in the deformation opening groups in the circumferential direction are consistent; in the circumferential direction, the first deformation mouth group, the second deformation mouth group, the third deformation mouth group and the fourth deformation mouth group are sequentially staggered by 90 degrees along the clockwise direction.
The distal end of the bend controlling wire is connected to the distal end side of the bend section 522, and extends out of the tail end of the steel pipe body through the inside of the steel pipe body.
The distal end of the steel tube body is in a needle shape.
The guide pipe 51 is arranged in the steel pipe body in a penetrating mode, the distal end of the guide pipe 51 is leveled with and connected with the distal end of the steel pipe body, the tail end of the guide pipe 51 penetrates out of the tail end of the steel pipe body, and the bending control wire is located on the outer side of the guide pipe 51.
In the catheter mechanism 5, the flexible steel tube 52 is controllably bent until the catheter 51 is positioned within the flexible steel tube 52, and the catheter 51 is a flexible tube, so that the catheter 51 can bend with the flexible steel tube 52 and is sucked through the catheter 51 when sucking the pituitary gland.
The steel pipe body comprises a straight pipe section 521 and a curved pipe section 522, which are connected together, the straight pipe section 521 is inflexible, the curved pipe section 522 is controllably curved, and the curved pipe section 522 is positioned at the distal end side of the straight pipe section 521, so that in practical use, part or all of the curved pipe section 522 is inserted into the brain, and the straight pipe section 521 is not substantially inserted into the brain, and thus, the curved pipe section 522 is controlled to bend, so that the distal end position of the catheter mechanism 5 is changed, and pituitary can be accurately sucked.
The curved pipe section 522 is provided with a deformation opening 523, the deformation opening 523 is C-shaped, and a plurality of deformation openings 523 are axially arranged at intervals, so that the curved pipe section 522 can be bent in the opening direction of the deformation opening 523.
For convenience of understanding, the deformation opening 523 of the first deformation opening group is a first deformation opening, the deformation opening 523 of the second deformation opening group is a second deformation opening, the deformation opening 523 of the third deformation opening group is a third deformation opening, the deformation opening 523 of the fourth deformation opening group is a fourth deformation opening, the first deformation opening is radially opposite to the third deformation opening, the second deformation opening is radially opposite to the fourth deformation opening, when the bending pipe section 522 is controlled to bend towards the opening direction of the first deformation opening by the bending wire, the opening of the first deformation opening deforms, and the opening of the third deformation opening becomes larger, so that the bending pipe section 522 can bend towards the opening direction of the first deformation opening; similarly, when the second deformation opening becomes smaller and the fourth deformation opening becomes larger, the curved pipe section 522 is curved toward the opening direction of the second deformation opening; when the third deformation opening becomes smaller and the first deformation opening becomes larger, the curved pipe section 522 is curved toward the opening direction of the third deformation opening; when the fourth deformation opening becomes smaller and the second deformation opening becomes larger, the curved pipe segment 522 is caused to curve toward the opening direction of the fourth deformation opening. It can be seen that bending of the bend section 522 is enabled arbitrarily by providing the above deformation openings 523.
The distal end of the bend controlling wire is connected to the distal end side of the bend 522 and extends from the tail end of the steel pipe body through the inside of the steel pipe body, so that when the bend of the bend 522 needs to be controlled, the bend 522 can be controlled to bend by pulling the bend controlling wire at the tail end.
In one embodiment, the steel pipe body is a tubular structure with a deformation opening 523 formed therein to form the aforementioned bend segment 522.
The distal end of the steel tube body is in a needle shape, so that the distal end of the catheter mechanism 5 is sharp, and the distal end of the catheter mechanism 5 can easily pierce through eardrum, thereby entering the brain.
The steel pipe body is provided with the deformation opening 523, so that the steel pipe body is not provided with sealing capability, namely pituitary suction can not be performed by means of the steel pipe body, the steel pipe body is internally provided with the guide pipe 51, the pituitary suction is performed by the guide pipe 51, and the bending of the bending pipe section 522 is adjusted by the bending control wire, so that the guide pipe 51 in the steel pipe body is also bent, and the guide pipe 51 can accurately suck the pituitary.
The bending control wire is positioned outside the catheter 51, so that the bending control wire does not affect the catheter 51 when the bending control wire is pulled, and the catheter 51 can suck pituitary.
Further, the straight pipe section 521 has a length of 40 to 60mm, for example, 40mm, 45mm, 50mm, 55mm, 60mm, or the like, and the curved pipe section 522 has a length of 10 to 20mm, for example, 10mm, 13mm, 15mm, 18mm, 20mm, or the like. The length of the curved pipe section 522 makes the part of the steel pipe body penetrating through the eardrum be the curved pipe section 522, and the straight pipe section 521 is basically positioned in the ear rod 4 finally, so that when the curved pipe section 522 is bent by controlling the curved wire, the curved pipe section 522 is more sensitive in bending due to the shorter length, and the distal end of the catheter mechanism 5 is easier to move to be close to the pituitary gland, thereby achieving the purpose of sucking the pituitary gland.
The shorter curved section also enhances the strength of the steel tube body so that the distal end of the catheter mechanism 5 is more prone to puncturing the eardrum.
The number of the bending control wires is four, namely a first bending control wire, a second bending control wire, a third bending control wire and a fourth bending control wire, wherein the first bending control wire corresponds to the first deformation port group, the second bending control wire corresponds to the second deformation port group, the third bending control wire corresponds to the third deformation port group, and the fourth bending control wire corresponds to the fourth deformation port group; the corresponding bend control filaments and deformation orifice groups are located on the same side of the bend segment 522.
The first bending control wire is pulled, the bending section can be bent towards the opening direction of the first deformation opening, the second bending control wire is pulled, the bending section can be bent towards the opening direction of the second deformation opening, the third bending control wire is pulled, the bending section can be bent towards the opening direction of the third deformation opening, the fourth bending control wire is pulled, and the bending section can be bent towards the opening direction of the fourth deformation opening. The corresponding bending wire can thus be pulled as needed to enable the distal end of the catheter mechanism 5 to be more easily brought closer to the pituitary gland.
The camera shooting mechanism further comprises an LED illuminating lamp 62, the LED illuminating lamp 62 and the camera 61 are installed at the far end of the extension tube side by side, and a lead of the LED illuminating lamp 62 penetrates through the extension tube and penetrates out of the tail end of the extension tube.
The brain is a dark space, and the LED illuminating lamp 62 can illuminate the space, so that the camera 61 can clearly shoot pituitary gland; the LED illumination lamp 62 is disposed side by side with the camera 61 such that the area illuminated by the LED illumination lamp 62 substantially overlaps with the area photographed by the camera 61, thereby ensuring that the camera 61 can clearly photograph an image.
The extension tube is a straight tube, and the far end of the extension tube is in a needle shape. The extension tube is non-deformable, and the distal end of the extension tube is in a needle shape, so that the extension tube is convenient to pierce the eardrum.
The distal end of the communication channel is provided with two through holes which are not communicated with each other, the distal end of the catheter mechanism 5 penetrates out of one through hole, and the distal end of the extension tube penetrates out of the other through hole. In actual use, the distal end of the catheter mechanism 5 passes through one via hole, and the distal end of the extension tube passes through the other via hole, so that the interference between the extension tube and the catheter mechanism 5 is avoided.
The rotation angle of the ear rod 4 is 12-18 degrees. The ear rod 4 is rotatably connected to the moving arm through a vertical rotating shaft, so that the ear rod 4 can rotate in the front-rear direction, the rotation angle of the ear rod 4 is 12-18 degrees, the ear rod 4 can rotate to an angle suitable for being inserted into ears, and the catheter mechanism 5 and the extension tube are conveniently guided into the brain.
The mouth fixing mechanism 1 comprises a height sliding rail, a connecting frame, a fixed toothed plate 11 and a pressing cap 12, wherein the height sliding rail is vertically arranged, the connecting frame is connected with the height sliding rail in a sliding manner, the pressing cap 12 and the fixed toothed plate 11 are both connected with the connecting frame, the pressing cap 12 is positioned on the upper side of the fixed toothed plate 11, an adjusting screw 13 is arranged between the pressing cap 12 and the fixed toothed plate 11, and the adjusting screw 13 penetrates through the pressing cap 12 to be in threaded connection with the fixed toothed plate 11 so as to adjust the distance between the pressing cap 12 and the fixed toothed plate 11; the tooth fixing plate 11 is provided with a tooth clamping opening 111.
The link can slide along high slide rail to change the height of link, and press cap 12 and fixed pinion rack all to be connected in the link, therefore can adjust the height of pressing cap 12 and fixed pinion rack, be equipped with the latch mouth 111 on the fixed pinion rack, conveniently insert the tooth of rat in the latch mouth 111, then will press cap 12 through adjusting screw 13 and push down, thereby cover the top of the head of rat from the top cap, thereby wholly fix the head of rat, make when absorbing the pituitary gland, the rat is more stable, ensure to pick up the pituitary gland smoothly.
Further, the press cap 12 includes a support block and an oval fixing ring 121, the fixing ring 121 is connected with a net bag, the fixing ring 121 is horizontally arranged, the fixing ring 121 is connected with the support block, and the adjusting screw 13 passes through the support block and is in threaded connection with the tooth fixing plate 11.
The fixing ring 121 is connected with a net bag, and when the cap 12 covers the head top of the rat from the upper side, the net bag can cover the head of the rat to better fix the head of the rat.
It will be understood that the above-described embodiments are merely illustrative and not restrictive, and that all obvious or equivalent modifications and substitutions to the details given above may be made by those skilled in the art without departing from the underlying principles of the invention, are intended to be included within the scope of the appended claims.
Claims (10)
1. The rat pituitary sucking system is characterized by comprising a head fixing device, a pituitary sucking mechanism and a camera shooting mechanism;
the head fixing device comprises a mouth fixing mechanism and two ear fixing mechanisms, wherein the two ear fixing mechanisms are a first ear fixing mechanism and a second ear fixing mechanism respectively, the first ear fixing mechanism and the second ear fixing mechanism are oppositely arranged left and right and can slide in the up-down direction and the left-right direction, and the mouth fixing mechanism is positioned at the front sides of the two ear fixing mechanisms and is positioned at the middle position of the two ear fixing mechanisms;
the ear fixing mechanism comprises a first moving track, a second moving track, a moving arm and an ear rod, wherein the first moving track extends along the vertical direction, the second moving track extends along the left-right direction, the moving arm is slidably mounted on the second moving track, the second moving track is mounted on the first moving track, the ear rod is rotatably connected with the moving arm, the rotating direction of the ear rod is the front-back direction, an axially-through communication channel is arranged in the ear rod, the far end of the ear rod of the first ear fixing mechanism faces the second ear fixing mechanism, the far end of the ear rod of the second ear fixing mechanism faces the first ear fixing mechanism, and in the left-right direction, the two ear rods are oppositely arranged;
the pituitary adsorption mechanism comprises a conduit mechanism and a negative pressure device, the conduit mechanism comprises an adjustable bent steel pipe and a conduit, the conduit is a deformable hose, the conduit is arranged in the adjustable bent steel pipe in a penetrating way, and the far end of the conduit mechanism is used for penetrating through a communication channel of the ear rod and penetrating out of the far end of the ear rod; the tail end of the conduit is also connected with the negative pressure device;
the camera shooting mechanism comprises an extension tube, a camera and a display device, the camera is arranged at the far end of the extension tube, a wire of the camera passes through the extension tube and passes out from the tail end of the extension tube, and the wire is connected with the display device; the distal end of the extension tube is configured to pass through the communication channel and out the distal end of the ear stem.
2. The rat pituitary aspiration system of claim 1, wherein the adjustable bend steel tube comprises a steel tube body and a bend control wire connected to the steel tube body, the steel tube body comprising a straight tube section and a bend section connected to each other, the bend section being located on a distal side of the straight tube section; the bending pipe section is provided with a plurality of deformation openings penetrating through the single-side wall of the bending pipe section, the deformation openings extend to two sides along the circumferential direction of the bending pipe section, and the deformation openings are arranged at intervals along the axial direction of the bending pipe section;
the deformation openings are divided into a first deformation opening group, a second deformation opening group, a third deformation opening group and a fourth deformation opening group, and the positions of the deformation openings in the deformation opening groups in the circumferential direction are consistent; in the circumferential direction, the first deformation mouth group, the second deformation mouth group, the third deformation mouth group and the fourth deformation mouth group are sequentially staggered by 90 degrees along the clockwise direction;
the distal end of the bending control wire is connected to the distal end side of the bending pipe section and extends out of the tail end of the steel pipe body through the inside of the steel pipe body;
the far end of the steel pipe body is in a needle shape;
the guide pipe penetrates through the steel pipe body, the far end of the guide pipe is leveled with and connected with the far end of the steel pipe body, the tail end of the guide pipe penetrates out of the tail end of the steel pipe body, and the bending control wire is located on the outer side of the guide pipe.
3. The rat pituitary aspiration system of claim 2, wherein the straight tube segment has a length of 40-60mm and the curved tube segment has a length of 10-20mm.
4. The rat pituitary aspiration system of claim 2, wherein the number of bend controlling filaments is four, being a first bend controlling filament, a second bend controlling filament, a third bend controlling filament, and a fourth bend controlling filament, respectively, the first bend controlling filament corresponding to the first set of deformation openings, the second bend controlling filament corresponding to the second set of deformation openings, the third bend controlling filament corresponding to the third set of deformation openings, the fourth bend controlling filament corresponding to the fourth set of deformation openings; in the corresponding bending control wire and deformation port group, the bending control wire and the deformation port group are positioned on the same side of the bending pipe section.
5. The rat pituitary suction system of any of claims 1-4, wherein said camera mechanism further comprises an LED light, said LED light and said camera being mounted side-by-side at a distal end of said extension tube, a wire of said LED light passing through said extension tube and out a trailing end of said extension tube.
6. The rat pituitary aspiration system of claim 5, wherein the extension tube is straight and has a distal end in the shape of a needle.
7. The rat pituitary aspiration system of any of claims 1-4, wherein the distal end of the communication channel is provided with two non-communicating vias, the distal end of the catheter mechanism is threaded out of one via and the distal end of the extension tube is threaded out of the other via.
8. The rat pituitary suction system of any of claims 1-4, wherein the rotation angle of the ear stem is 12-18 °.
9. The rat pituitary suction system of any of claims 1-4, wherein said mouth fixation mechanism comprises a height slide rail, a connecting frame, a tooth fixing plate and a pressure cap, said height slide rail is vertically arranged, said connecting frame is slidingly connected to said height slide rail, said pressure cap and said tooth fixing plate are both connected to said connecting frame, and said pressure cap is positioned on the upper side of said tooth fixing plate, an adjusting screw is disposed between said pressure cap and said tooth fixing plate, said adjusting screw is threaded through said pressure cap and said tooth fixing plate to adjust the spacing between said pressure cap and said tooth fixing plate;
and the tooth fixing plate is provided with a tooth clamping opening.
10. The rat pituitary aspiration system of claim 9, wherein the pressure cap comprises a support block and an oval-shaped fixed ring, wherein a net bag is connected to the fixed ring, the fixed ring is horizontally arranged, the fixed ring is connected with the support block, and the adjusting screw passes through the support block and is in threaded connection with the fixed toothed plate.
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| CN116531139B (en) | 2023-09-29 |
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