CN116491896A - Gastrointestinal tumor diagnosis system - Google Patents
Gastrointestinal tumor diagnosis system Download PDFInfo
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- CN116491896A CN116491896A CN202310283143.7A CN202310283143A CN116491896A CN 116491896 A CN116491896 A CN 116491896A CN 202310283143 A CN202310283143 A CN 202310283143A CN 116491896 A CN116491896 A CN 116491896A
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- 208000002699 Digestive System Neoplasms Diseases 0.000 title claims abstract description 16
- 238000003745 diagnosis Methods 0.000 title abstract description 22
- 238000001514 detection method Methods 0.000 claims abstract description 40
- 238000012545 processing Methods 0.000 claims abstract description 16
- 230000005284 excitation Effects 0.000 claims abstract description 10
- 239000000523 sample Substances 0.000 claims description 34
- 238000002073 fluorescence micrograph Methods 0.000 claims description 10
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 claims description 10
- 229960004657 indocyanine green Drugs 0.000 claims description 10
- 230000005540 biological transmission Effects 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 17
- 210000001165 lymph node Anatomy 0.000 abstract description 11
- 210000001519 tissue Anatomy 0.000 abstract description 9
- 206010027476 Metastases Diseases 0.000 abstract description 5
- 230000009401 metastasis Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 230000002980 postoperative effect Effects 0.000 abstract description 2
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000007547 defect Effects 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 5
- 230000002452 interceptive effect Effects 0.000 description 5
- 230000001926 lymphatic effect Effects 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000799 fluorescence microscopy Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000004324 lymphatic system Anatomy 0.000 description 2
- 210000001365 lymphatic vessel Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
- A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
- A61B8/5261—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from different diagnostic modalities, e.g. ultrasound and X-ray
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Vascular Medicine (AREA)
- Closed-Circuit Television Systems (AREA)
Abstract
The invention discloses a gastrointestinal tumor diagnosis system in the field of medical appliances, which comprises: the navigation system comprises a fluorescence excitation device and an image acquisition device; the detection system comprises an ultrasonic transmitting device, an ultrasonic receiving device and a position pointer; and the computer data processing system is electrically connected with the navigation system and the detection system, wherein the image acquisition device is used for acquiring fluorescent image information and transmitting the fluorescent image information to the computer data processing system, the ultrasonic receiving device is used for receiving ultrasonic data and transmitting the ultrasonic data to the computer data processing system, and the computer data processing system is used for displaying the fluorescent image information and displaying three-dimensional ultrasonic digital tissue slice information according to the ultrasonic data and the position pointer. The diagnosis system can detect the potential tumor cell metastasis positive lymph node, increase the detection rate of the positive lymph node, improve the diagnosis precision, reduce the false negative rate, improve the operation precision and the radical tumor treatment effect, and reduce the postoperative recurrence rate.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a gastrointestinal tumor diagnosis system.
Background
For gastrointestinal malignant tumor surgery, the ultrasonic laparoscope relies on a surgical probe to collect three-dimensional information of a small-range tissue, so that the problems of boundary noise and distortion of a three-dimensional ultrasonic laparoscope interactive marking target area are easy to occur, the problem of difficult positioning of a complex anatomical area is caused, and the diagnosis efficiency is greatly reduced for tumors with unclear boundaries or wider occupation.
The fluorescence endoscope can not specifically mark tumors, so that in application, the defect of filling of a lymphatic system caused by late occupation and jump metastasis of the tumors exists, near infrared navigation information can not be acquired in a filling defect section, and in the areas suspected to have the defect of filling of the lymph in the operation, such as subpylorus areas of the radical gastric cancer treatment operation, the areas are often difficult to be dissected, the lymph nodes are often difficult to find under the conventional fluorescence laparoscope, and the cleaning of the lymph nodes is critical, so that the accuracy of the operation and the postoperative recurrence rate are determined.
Disclosure of Invention
The utility model provides a gastrointestinal tumor diagnosis system solves the problem of difficult malignant tumor diagnosis in the prior art, and improves the diagnosis efficiency and accuracy of malignant tumor.
Embodiments of the present application provide a gastrointestinal tumor diagnostic system comprising:
the navigation system comprises a fluorescence excitation device and an image acquisition device;
the detection system comprises an ultrasonic transmitting device, an ultrasonic receiving device and a position pointer;
the computer data processing system is electrically connected with the navigation system and the detection system, wherein the fluorescence excitation device is used for emitting near infrared light to excite a medium indocyanine green to generate fluorescence, the image acquisition device is used for acquiring fluorescence image information and sending the fluorescence image information to the computer data processing system, the ultrasonic transmission device is used for transmitting ultrasonic waves, the ultrasonic receiving device is used for receiving ultrasonic wave data and sending the ultrasonic wave data to the computer data processing system, and the computer data processing system is used for displaying the fluorescence image information and displaying three-dimensional ultrasonic wave digital tissue slice information according to the ultrasonic wave data and the position pointer.
The beneficial effects of the above embodiment are that: the diagnosis system is characterized in that a fluorescence excitant indocyanine green submucosal injection is needed to be performed in advance by adopting a four-point method or a six-point method around a tumor, fluorescence which is visible and extremely high in identification degree with surrounding tissues is excited by near infrared light in the operation, so that strong interactable tumor lymphatic drainage imaging is presented in real time, tumor position information and marginal information are provided, boundary marks are provided for digital acquisition of three-dimensional ultrasonic sections, auxiliary positioning is performed, ultrasonic attenuation signals are obtained through ultrasonic detection, continuous tissue section information is generated through three-dimensional reconstruction, indocyanine green which is caused by occupying a blocked lymphatic vessel cannot reach the infiltrated and marked lymph nodes, the lymph nodes are often prompted to have tumor metastasis, diagnosis information of the lymph nodes is deficient in single-use fluorescence navigation, real-time detection and diagnosis are performed in the operation by a doctor, the detection rate of the lymph nodes is improved, decision and accurate excision in the operation are guided, and the radical treatment effect of the tumor and the prognosis of a patient are improved.
Based on the above embodiments, the present application may be further improved, specifically as follows:
in one embodiment of the present application, the detection system further includes a detection arm and an ultrasonic probe, the ultrasonic probe is mounted at the front end of the detection arm, and the ultrasonic transmitting device and the ultrasonic receiving device are both disposed on the same ultrasonic probe.
In one embodiment of the present application, the detection system further includes a sample reference arm, where the sample reference arm is used to assist in judging the ultrasonic detection result. The sample reference arm is provided with an optical reflector, a collimating mirror and an ultrasonic receiving device, receives ultrasonic information from outside the sample, performs data acquisition, and finally compares the ultrasonic information with three-dimensional sample information to generate a three-dimensional phantom data set, so that a doctor can be helped to quickly judge pathological changes of the tissue to be detected.
In one embodiment of the present application, the ultrasonic probe includes a rigid member located at the rear end and a flexible member located at the front end, one end of the rigid member is connected to the detection arm, the other end is connected to the flexible member, and the ultrasonic transmitting device and the ultrasonic receiving device are both disposed on the flexible member. The flexible probe brings a plurality of flexible detection modes for operation, such as a common vertical flat scanning mode, a side detection mode, a rigid side view linear array detection mode and a linear array detection mode, and the stability of the probe is ensured by the rigid structure.
In one embodiment of the present application, the fluorescence excitation device is configured to generate near infrared light of 830nm to 850 nm. Near infrared light of 830 nm-850 nm is used for exciting the fluorescence exciting agent indocyanine green to generate fluorescence.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. Like elements or portions are generally identified by like reference numerals throughout the several figures. In the drawings, elements or portions thereof are not necessarily drawn to scale.
FIG. 1 is a block diagram of a gastrointestinal tumor diagnosis system according to the present invention;
FIG. 2 is a schematic diagram of the structure of an ultrasonic probe;
wherein, 1, rigid piece, 2, flexible piece, 3, ultrasonic emission device, 4, ultrasonic receiving arrangement.
Detailed Description
The present invention is further illustrated below in conjunction with the specific embodiments, it being understood that these embodiments are meant to be illustrative of the invention only and not limiting the scope of the invention, and that modifications of the invention, which are equivalent to those skilled in the art to which the invention pertains, will fall within the scope of the invention as defined in the claims appended hereto.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the description of the present invention, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
In the description of the present invention, the schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the various embodiments or examples of the invention described and the features of the various embodiments or examples may be combined and combined by those skilled in the art without contradiction.
According to the gastrointestinal tumor diagnosis system, the problem that malignant tumors are difficult to diagnose in the prior art is solved, and the diagnosis efficiency and accuracy of the malignant tumors are improved.
The technical scheme in the embodiment of the application aims to solve the problems, and the overall thought is as follows:
examples:
as shown in fig. 1, an embodiment of the present application provides a gastrointestinal tumor diagnosis system, including a navigation system, a detection system, and a computer data processing system;
the navigation system comprises a fluorescence excitation device and an image acquisition device, wherein near infrared light of 830-850 nm is excited by the fluorescence excitation device to excite fluorescence excitation agent indocyanine green, and the image acquisition device acquires fluorescence image information and sends the fluorescence image information to the computer data processing system;
the detection system comprises an ultrasonic transmitting device, an ultrasonic receiving device and a position pointer, wherein the ultrasonic transmitting device is controlled by a special laparoscope ultrasonic probe held by an operator and is used for transmitting ultrasonic waves, and the ultrasonic receiving device is used for receiving ultrasonic data and sending the ultrasonic data to the computer data processing system;
the computer data processing system is electrically connected with the navigation system and the detection system, receives the fluorescence image information and displays the fluorescence image information on the interactive interface, calculates the received ultrasonic data, and refers to the position pointer to reconstruct and display three-dimensional ultrasonic digital tissue slice information on the interactive interface in a three-dimensional mode.
Further, the detection system further comprises a detection arm and an ultrasonic probe, the ultrasonic probe is arranged at the front end of the detection arm, the ultrasonic probe is preferably a flexible ultrasonic probe, as shown in fig. 2, the flexible ultrasonic probe comprises a rigid part 1 positioned at the rear end and a flexible part 2 positioned at the front end, one end of the rigid part 1 is connected with the detection arm, the other end of the rigid part is connected with the flexible part 2, and an ultrasonic transmitting device 3 and an ultrasonic receiving device 4 are both arranged on the flexible part 2. The ultrasonic probe is corrected by the detection arm according to the equipment position pointer, and the flexible probe brings a plurality of flexible detection modes in operation, such as a common vertical flat scanning mode, a side detection mode, a rigid side view linear array detection mode and a linear array detection mode, and the stability of the probe is ensured by the rigid structure.
Further, the detection system further comprises a sample reference arm, and the sample reference arm is used for assisting in judging the ultrasonic detection result. The sample reference arm is provided with an optical reflector, a collimating mirror and an ultrasonic receiving device, receives ultrasonic information from outside the sample, performs data acquisition, and finally compares the ultrasonic information with three-dimensional sample information to generate a three-dimensional phantom data set, so that a doctor can be helped to quickly judge pathological changes of the tissue to be detected.
The technical scheme in the embodiment of the application at least has the following technical effects or advantages:
1. the gastrointestinal tract tumor diagnosis system solves the problem that the indocyanine green-dependent near-infrared fluorescence imaging navigation system lacks tumor specificity, the indocyanine green cannot specifically mark tumors, so that in the application, the filling defect of a lymphatic system caused by late occupation and jump metastasis of the tumors exists, near-infrared navigation information cannot be acquired in the filling defect section, an ultrasonic attenuation signal is returned through a three-dimensional ultrasonic laparoscope probe, continuous tissue three-dimensional slice information is generated through three-dimensional reconstruction, a potential occupied blocked lymphatic vessel is detected, the detection rate of positive lymph nodes is increased, the diagnosis precision is improved, and the false negative rate is reduced.
2. The gastrointestinal tumor diagnosis system solves the problems of boundary noise and distortion of a three-dimensional ultrasonic laparoscope interactive marking target area and difficult positioning of a complex anatomical area, and the indocyanine green-mediated near-infrared fluorescence imaging system can realize real-time presentation of strong interactive tumor lymphatic drainage imaging, provide tumor position information and marginal information, provide boundary marking for digital acquisition of three-dimensional ultrasonic slices and assist in positioning.
3. The gastrointestinal tumor diagnosis system solves the problems of difficult lymph node cleaning and difficult diagnosis caused by anatomic difficulties and jumping metastasis in the operation. For the region suspected of lymphatic filling defects in the operation, the tumor state of the region is easily assessed and the potential metastatic lymph nodes are found by ultrasonic three-dimensional localization and indocyanine green fluorescence real-time development. The technical problem to be solved by the system is helpful for the tumor surgery to further improve the accuracy in the operation, improve the survival after the operation and reduce the recurrence rate after the operation.
While embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the invention, and that variations, modifications, alternatives and variations may be made to the above embodiments by one of ordinary skill in the art within the scope of the invention.
Claims (5)
1. A gastrointestinal tumor diagnostic system, comprising:
the navigation system comprises a fluorescence excitation device and an image acquisition device;
the detection system comprises an ultrasonic transmitting device, an ultrasonic receiving device and a position pointer;
the computer data processing system is electrically connected with the navigation system and the detection system, wherein the fluorescence excitation device is used for exciting medium indocyanine green by near infrared light to generate fluorescence, the image acquisition device is used for acquiring fluorescence image information and sending the fluorescence image information to the computer data processing system, the ultrasonic transmission device is used for transmitting ultrasonic waves, the ultrasonic receiving device is used for receiving ultrasonic wave data and sending the ultrasonic wave data to the computer data processing system, and the computer data processing system is used for displaying the fluorescence image information and displaying three-dimensional ultrasonic wave digital tissue slice information according to the ultrasonic wave data and the position pointer.
2. The gastrointestinal tumor diagnostic system according to claim 1, wherein: the detection system further comprises a detection arm and an ultrasonic probe, wherein the ultrasonic probe is arranged at the front end of the detection arm, and the ultrasonic transmitting device and the ultrasonic receiving device are both arranged on the same ultrasonic probe.
3. The gastrointestinal tumor diagnostic system according to claim 2, wherein: the detection system further comprises a sample reference arm, wherein the sample reference arm is used for assisting in judging an ultrasonic detection result.
4. The gastrointestinal tumor diagnostic system according to claim 2, wherein: the ultrasonic probe comprises a rigid piece positioned at the rear end and a flexible piece positioned at the front end, one end of the rigid piece is connected with the detection arm, the other end of the rigid piece is connected with the flexible piece, and the ultrasonic transmitting device and the ultrasonic receiving device are both arranged on the flexible piece.
5. The gastrointestinal tumor diagnostic system according to claim 1, wherein: the fluorescence excitation device is used for generating near infrared light of 830 nm-850 nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310283143.7A CN116491896A (en) | 2023-03-22 | 2023-03-22 | Gastrointestinal tumor diagnosis system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310283143.7A CN116491896A (en) | 2023-03-22 | 2023-03-22 | Gastrointestinal tumor diagnosis system |
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| Publication Number | Publication Date |
|---|---|
| CN116491896A true CN116491896A (en) | 2023-07-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310283143.7A Pending CN116491896A (en) | 2023-03-22 | 2023-03-22 | Gastrointestinal tumor diagnosis system |
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| CN (1) | CN116491896A (en) |
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- 2023-03-22 CN CN202310283143.7A patent/CN116491896A/en active Pending
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