CN116486905A - Vaccine derived poliovirus neutralization antigen mutation site information analysis processing system - Google Patents

Vaccine derived poliovirus neutralization antigen mutation site information analysis processing system Download PDF

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Publication number
CN116486905A
CN116486905A CN202310451303.4A CN202310451303A CN116486905A CN 116486905 A CN116486905 A CN 116486905A CN 202310451303 A CN202310451303 A CN 202310451303A CN 116486905 A CN116486905 A CN 116486905A
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China
Prior art keywords
module
cover
ring
data
virus
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CN202310451303.4A
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Inventor
严冬梅
张勇
许文波
祝双利
王东艳
李晓嫘
朱晖
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National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention
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National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention
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Priority to CN202310451303.4A priority Critical patent/CN116486905A/en
Publication of CN116486905A publication Critical patent/CN116486905A/en
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    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
    • B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
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    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B3/00—Closing bottles, jars or similar containers by applying caps
    • B67B3/20—Closing bottles, jars or similar containers by applying caps by applying and rotating preformed threaded caps
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
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Abstract

The invention relates to a vaccine derived poliovirus neutralization antigen mutation site information analysis processing system, which comprises an analysis processing module, a virus module and a region data acquisition module, wherein the analysis processing module is respectively connected with the virus module and the region data acquisition module, the analysis processing module comprises an annotation module, a data analysis module, a display module, a cloud data storage module and a deep learning module, and the virus module comprises an incubation module, a virus detection module and a virus sampling module; the invention has the advantage of avoiding VDPVs circulation and epidemic outbreaks.

Description

Vaccine derived poliovirus neutralization antigen mutation site information analysis processing system
Technical Field
The invention belongs to the technical field of virus neutralization antigen mutation site information analysis processing systems, and particularly relates to a vaccine derived poliovirus neutralization antigen mutation site information analysis processing system.
Background
Poliomyelitis (polio) is also known as poliomyelitis, an acute infectious disease caused by poliovirus. The 42 nd world health agency in 1989 passed the global action plan for eliminating ridge ash, which is the greatest public health action plan historically, and the advent of oral live attenuated ridge ash Vaccine in 1961 made the implementation of this plan a reality, and the use of OPV eliminated most of the ridge ash field virus worldwide, however the disadvantage of OPV Vaccine itself-Vaccine derived ridge ash virus (Vaccine-derived poliovirus, VDPV) became the focus of current epidemiologist and virologist attention.
VDPV, although derived from OPV, has biological properties similar to that of the Gray field virus, has high neurotoxicity, can cause delayed paralysis in vaccinators, and can spread like the field virus among people. The first recognition that VDPV is the type I VDPV cycle (cVDPV) occurring in the islands of sea in 2000-2001 resulted in a total of 22 cases of confirmed diagnosis of ridge ash (including 2 cases of death). Since 2000, there have been 28 countries around the world with outbreaks of VDPVs, and some countries have repeated and persistent outbreaks of VDPVs, so that VDPVs may become the greatest threat in achieving the destruction of the ridge ash program around the world after the ridge ash field virus is destroyed;
in the prior art, whether the new VDPVs cause immune escape or not cannot be judged according to the factors such as whether the new VDPVs generate amino acid mutation on a neutralizing antigen site, and the clinical manifestation of the case of the new VDPVs, the local vaccine immune coverage condition, the local economic condition and the like, and information analysis processing is performed, so that the circulation of the VDPVs and outbreak of epidemic situation can possibly occur.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a vaccine derived poliovirus neutralization antigen mutation site information analysis processing system capable of avoiding VDPVs circulation and epidemic outbreaks.
The technical scheme of the invention is as follows:
the vaccine derived poliovirus neutralization antigen mutation site information analysis processing system comprises an analysis processing module, a virus module and a region data acquisition module, wherein the analysis processing module is respectively connected with the virus module and the region data acquisition module, the analysis processing module comprises an annotation module, a data analysis module, a display module, a cloud data storage module and a deep learning module, and the virus module comprises an incubation module, a virus detection module and a virus sampling module;
the data analysis module is used for comparing and analyzing data and judging whether immune escape is caused or not based on the result of the comparing and analyzing;
the cloud data storage module is used for realizing data storage by adopting a cloud database and can be connected with the Internet to acquire virus types and different types of data, wherein the cloud data storage module can autonomously classify the viruses according to the different virus types acquired by the Internet;
the deep learning module adopts a neural network to realize deep learning, and the learning content is different types of data of the cloud data storage module and data detected by the virus module;
the display module displays data by adopting a display;
the annotation module is used for annotating and labeling based on the data displayed by the display module;
the incubation module incubates viruses by adopting virus incubation equipment;
the virus detection module detects viruses incubated by the incubation module and transmits detected data to the incubation data comparison module.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, virus sampling is realized through the virus sampling module, incubation of the virus is realized through the incubation module, and finally detection of virus data is realized through the virus detection module, so that detection of the virus is facilitated;
2. according to the invention, the deep learning module is adopted to learn according to the data searched by the cloud data storage module, and the data analysis module is used for analyzing the collected virus data, so that the analysis of the virus data is convenient, and the virus data is transmitted into the deep learning module according to the analysis result, so that the subsequent recognition speed is accelerated;
3. the method adopts a regional data acquisition module to acquire regional data of vaccine derived poliovirus, and determines whether immune escape is caused or not based on the regional data so as to take corresponding measures and timely block the transmission of the poliovirus;
in summary, the invention has the advantage of avoiding VDPVs circulation and epidemic outbreaks.
Further, the regional data acquisition module comprises a virus clinical data module and a regional data module;
the virus clinical data module adopts a camera to collect clinical image information of a patient, acquires clinical detection data of the patient by a hospital, and transmits the detection data into the data analysis module;
the regional data module is used for acquiring the local vaccine immune coverage rate and the local economic condition and transmitting the acquired data into the data analysis module.
Further, the virus sampling module comprises a cylindrical storage box, a plurality of collecting pipes arranged in the storage box, a sealing cover detachably connected to the upper side surface of the storage box, a control main board and a lithium battery electrically connected with the control main board, wherein the sealing cover is in sealing connection with the storage box, the collecting pipes are circularly distributed by taking the center of the circle of the upper side surface of the storage box as a center point, a driving component for driving the single collecting pipe to rotate is arranged at the bottom of the storage box, and the driving component is electrically connected with the control main board;
the sealing cover is provided with cover bodies with the same number as the collection tubes, the sealing cover can cover the cover bodies on the collection tubes, and when the cover bodies cover the collection tubes, the driving assembly drives the corresponding collection tubes to rotate so that the cover bodies are connected to the collection tubes in a threaded mode.
Further, the driving assembly comprises a rotary table positioned at the bottom of the collecting pipe, a gear, a motor and a fluted disc which are arranged at the bottom of the rotary table, the rotary table is rotationally connected to the storage box, a plurality of arc-shaped grooves are formed in the upper side face of the rotary table, the circle centers of the arc-shaped grooves are concentric and positioned below the center of the bottom of the collecting pipe, and the bottom of the collecting pipe is provided with a protrusion which can be inserted into the arc-shaped grooves;
the bottom of the storage box is provided with a cavity, the gear and the fluted disc are positioned in the cavity, the fluted disc is connected in the cavity through a bearing, and the fluted disc is provided with meshing teeth meshed with the gear;
the motor is connected with the fluted disc, and the motor is electrically connected with the control main board.
Further, the storage box is provided with a meshing assembly positioned at the outer side of the collection pipe, the meshing assembly comprises a plurality of guide rods vertically inserted into the storage box, a meshing ring arranged at the upper end of the guide rods and a meshing spring positioned between the meshing ring and the storage box, the storage box is internally provided with a guide groove, and the guide rods are inserted into the guide groove and cannot be separated from the guide groove;
the upper side surface of the meshing ring can be meshed with the cover body teeth, and the meshing ring is sleeved on the collecting pipe;
the engagement spring cannot push the collection tube upward.
Further, the sealing cover comprises an outer ring, an inner cover rotationally connected to the outer ring, a cover feeding assembly arranged at the center of the bottom of the inner cover, a mounting ring and a discharging ring, wherein the outer ring is in threaded connection to the storage box, and the circle center of the mounting ring is concentric with the circle center of the inner cover;
the inner cover is provided with a ring groove, the mounting ring is detachably arranged on the inner cover and the cover feeding component to form a cover body groove, the cover body is annularly arranged in the cover body groove, the opening of the cover body arranged in the cover body groove faces downwards, the groove depth of the cover body groove is the same as the height of the cover body, one end of the mounting ring is provided with a notch, a pressing component positioned in the ring groove is arranged in the notch, the pressing component is electrically connected with the control main board, the cover feeding component can feed the cover body in the cover body groove into the pressing component, and the pressing component can press the cover body down to one of the collecting pipes;
the inner cover is provided with a sampling port, the distance between the sampling port and the pressing component is the same as the distance between the adjacent collecting pipes, and a sealing plug is inserted into the sampling port;
the discharging ring is placed on the storage box, the lower side face of the inner cover is abutted against the discharging ring, the discharging ring is provided with a port corresponding to the collecting pipe, and the cover body can pass through the port on the discharging ring.
Further, the cover feeding assembly comprises a cylinder positioned at the center of the lower side surface of the inner cover, a disc arranged at the center of the lower side surface of the cylinder, a return spring sleeved on the cylinder and an extrusion plate positioned in the cover body groove, one end of the return spring is fixed on the cylinder, a gap is arranged between the mounting ring and the inner cover to form a sliding groove, the other end of the return spring penetrates through the sliding groove to be connected onto the extrusion plate, one side of the extrusion plate is provided with a limiting assembly positioned on the inner cover, and when the extrusion plate rotates to the maximum angle, the limiting assembly limits the extrusion plate;
the disc bottom is connected with the connector through electrically conductive sliding ring, deposit the case upside and be provided with the interface of being connected with the control mainboard electricity, connect grafting in the interface, electrically conductive sliding ring electricity is connected and is pushed down the subassembly.
Further, spacing subassembly is including being located the pressing board of inner cup upside, sealed polygon section of thick bamboo of passing the inner cup and peg graft the polygon pole in polygon section of thick bamboo, polygon pole can not break away from polygon section of thick bamboo when shifting up, pressing board passes through spring coupling polygon pole, be provided with on the pressing board and press the son and detain, be provided with on the inner cup with press the son and detain the pressing female knot of pressing the locking, the one end that the polygon pole is located the sliding tray is provided with the chamfer to make the squeezing board can promote polygon pole when clockwise rotation and shift up.
Further, the pushing component comprises a pore plate positioned at a notch of the mounting ring, a permanent magnet positioned above the pore plate, a guide cylinder positioned on the permanent magnet and an electromagnet positioned above the guide cylinder, wherein the pore plate is fixed on the inner cover, a blind hole for fixing the power supply magnet is formed in the annular groove, when the electromagnetic magnet attracts the permanent magnet, the lower side surface of the permanent magnet does not protrude out of the blind hole, the electromagnetic magnet is electrically connected with the conductive slip ring, a discharge hole is formed in the pore plate, the permanent magnet is positioned above the discharge hole, and a limiting plate positioned on the annular groove is arranged on one side of the discharge hole, so that the cover body can move downwards from the discharge hole when contacting the limiting plate;
at least three strip-shaped grooves are vertically formed in the side face of the guide cylinder and the side face of the annular groove, and balls are arranged in the strip-shaped grooves, so that the guide cylinder can only move up and down;
an elastic ring is arranged in the discharge hole, and the inner ring of the elastic ring is smaller than the diameter of the cover body;
the sampling port is positioned at one side of the limiting plate far away from the permanent magnet.
Further, the lateral surface of inner cup and the medial surface contact of depositing the case, and the standing groove has all been seted up to the contact side, be provided with the trigger electrode piece that corresponds with collection pipe quantity and position in the standing groove of depositing the case, be provided with the contact electrode piece that corresponds with the permanent magnet position in the standing groove of inner cup, the conductive slip ring is connected to contact electrode piece electricity, trigger electrode piece electricity connection control mainboard.
Drawings
FIG. 1 is a system architecture diagram of the present invention;
FIG. 2 is a schematic diagram of a virus sampling module of FIG. 1 according to the present invention;
FIG. 3 is a schematic view of the seal cap of FIG. 2 according to the present invention;
FIG. 4 is an enlarged schematic view of the portion A of FIG. 2 according to the present invention;
FIG. 5 is an enlarged schematic view of the portion B of FIG. 2 according to the present invention;
FIG. 6 is an enlarged schematic view of portion C of FIG. 2 in accordance with the present invention;
FIG. 7 is a schematic view of the bottom structure of FIG. 3 according to the present invention;
FIG. 8 is a schematic view of the mounting ring of FIG. 7 according to the present invention;
FIG. 9 is a perspective view of the mounting cap of FIG. 3 in accordance with the present invention;
FIG. 10 is a schematic cross-sectional view of FIG. 9 in accordance with the present invention;
FIG. 11 is an enlarged schematic view of the portion D of FIG. 10 according to the present invention;
FIG. 12 is a schematic view of the spacing assembly of FIG. 3 according to the present invention;
FIG. 13 is a schematic view of the structure of the toothed disc of FIG. 2 according to the present invention.
In the figure, 1, a storage box, 2, a collection tube, 3, a bulge, 4, a turntable, 5, a fluted disc, 51, meshing teeth, 6, gears, 7, a motor, 8, a lithium battery, 9, a control main board, 10, a pressing component, 101, an electromagnet, 102, a guide tube, 103, an elastic ring, 104, a permanent magnet, 105, a limit plate, 11, a cap feeding component, 111, a return spring, 113, a squeeze plate, 12, a ring groove, 13, a seal cover, 131, an outer ring, 132, an inner cover, 1321, a placement groove, 1322, a contact electrode plate, 133, a discharge ring, 134, a connector, 136, a mounting ring, 137, a discharge hole, 14, a meshing component, 141, a meshing ring, 142, a guide rod, 143, a meshing spring, 15, a trigger electrode plate, 16, a sampling hole, 17, a seal plug, 18, a limit component, 181, a polygonal rod, 182, a polygonal cylinder, 183, a pressing sub-button, 184, a pressing plate, 19, and a warning lamp.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
1-13, the vaccine derived poliovirus neutralization antigen mutation site information analysis processing system comprises an analysis processing module, a virus module and a region data acquisition module, wherein the analysis processing module is respectively connected with the virus module and the region data acquisition module, the analysis processing module comprises an annotation module, a data analysis module, a display module, a cloud data storage module and a deep learning module, and the virus module comprises an incubation module, a virus detection module and a virus sampling module;
the data analysis module is used for comparing and analyzing data and judging whether immune escape is caused or not based on the result of the comparing and analyzing.
The cloud data storage module is used for realizing data storage by adopting a cloud database and can be connected with the Internet to acquire virus types and different types of data, wherein the cloud data storage module can autonomously classify the viruses according to the different virus types acquired by the Internet;
the deep learning module adopts a neural network to realize deep learning, and the learning content is different types of data of the cloud data storage module and data detected by the virus module;
the display module displays data by adopting a display;
the annotation module is used for annotating and labeling based on the data displayed by the display module;
the incubation module incubates viruses by adopting virus incubation equipment;
the virus detection module detects viruses incubated by the incubation module and transmits detected data to the incubation data comparison module.
In this embodiment, the regional data acquisition module includes a viral clinical data module and a regional data module;
the virus clinical data module adopts a camera to collect clinical image information of a patient, acquires clinical detection data of the patient by a hospital, and transmits the detection data into the data analysis module;
the regional data module is used for acquiring the local vaccine immune coverage rate and the local economic condition and transmitting the acquired data into the data analysis module.
In this embodiment, the virus sampling module includes a cylindrical storage box 1, a plurality of collection tubes 2, a sealing cover 13 detachably connected to the upper side of the storage box 1, a control main board 9, and a lithium battery 8 electrically connected to the control main board 9, wherein a plurality of insertion holes are formed in the upper side of the storage box 1 in a circular shape with the center of a circle as a midpoint, the control board and the lithium battery 8 are both disposed in the storage box 1, the sealing cover 13 is in sealing connection with the storage box 1, the plurality of collection tubes 2 are inserted in the insertion holes, a driving component for driving the single collection tube 2 to rotate is disposed at the bottom of the storage box 1, and the driving component is electrically connected to the control main board 9;
the sealing covers 13 are provided with covers the same as the collection tubes 2 in number, the sealing covers 13 can cover the covers on the collection tubes 2, and when the covers cover the collection tubes 2, the driving assembly drives the corresponding collection tubes 2 to rotate so that the covers are connected to the collection tubes 2 in a threaded manner;
when the sampling device is used, the sampling tube 2 is inserted into the inserting hole, then the sealing cover 13 is fixed on the storage box 1, then the storage box 1 is carried to a sampling site, when sampling is needed, sampling is carried out through a cotton swab or other objects, then the sampling part of the cotton swab is placed into the sampling tube 2 from the sealing cover 13, then the sealing cover 13 is rotated, the cover body is aligned up and down with the sampling tube 2, then the sealing cover 13 covers the cover body, the control main board 9 controls the driving assembly to drive the corresponding sampling tube 2 to rotate, and the cover body is fixedly connected with the sampling tube 2 in a threaded manner, so that the sealing of the sampling tube 2 is realized.
In the embodiment, the driving assembly comprises a rotary table 4 positioned at the bottom of the collecting tube 2, a gear 6 arranged at the bottom of the rotary table 4, a motor 7 and a fluted disc 5, wherein the rotary table 4 is connected at the bottom of the inserting hole through a bearing, a plurality of arc-shaped grooves are formed in the upper side surface of the rotary table 4, the circle centers of the arc-shaped grooves are concentric and positioned below the center of the bottom of the collecting tube 2, and a protrusion 3 which can be inserted in the arc-shaped grooves is integrally formed at the bottom of the collecting tube 2;
the bottom of the storage box 1 is provided with a cavity, the gear 6 and the fluted disc 5 are positioned in the cavity, the fluted disc 5 is connected in the cavity through a bearing, the fluted disc 5 is integrally formed with meshing teeth 51 meshed with the gear 6, the number of teeth of the meshing teeth 51 is at least three times that of the gear 6, so that the collecting tube 2 can rotate for three or more circles, and the meshing teeth 51 can be placed in the interval between the adjacent gears 6;
the motor 7 is connected with the fluted disc 5 through a key, and the motor 7 is electrically connected with the control main board 9;
preferably, the motor 7 can also adopt a reduction gear 6 group to realize transmission with the fluted disc 5, so that the overlarge rotation angle of the fluted disc 5 is avoided, and the driving control is easy;
when the collecting tube 2 needs to be driven to rotate, the control main board 9 controls the motor 7 to work, the motor 7 drives the meshing teeth 51 to rotate through the fluted disc 5, when the meshing teeth 51 are contacted with the gear 6, the gear 6 drives the collecting tube 2 to rotate through the rotary disc 4, the arc-shaped groove and the collecting tube 2, so that the driving of the collecting tube 2 is ensured, when the meshing teeth 51 are not contacted with the gear 6, the gear 6 does not rotate any more, and when the next rotary disc 4 needs to be driven, the motor 7 is continuously controlled to rotate;
the protrusions 3 can be conveniently inserted into the arc grooves by a plurality of arc grooves when the collecting tube 2 is inserted.
In this embodiment, the storage box 1 is provided with a meshing assembly 14 located at the outer side of the collection tube 2, the meshing assembly 14 comprises a plurality of guide rods 142 vertically inserted on the storage box 1, a meshing ring 141 fixedly connected to the upper ends of the guide rods 142, and a meshing spring 143 located between the meshing ring 141 and the storage box 1, a guide groove is formed in the storage box 1, and the guide rods 142 are provided with limit balls located in the guide groove so that the guide rods 142 cannot be separated from the guide groove;
the upper side surface of the engagement ring 141 can be engaged with the cover teeth, and the engagement ring 141 is sleeved on the acquisition tube 2;
the collecting tube 2 can not push the collecting tube 2 to be separated from the plug hole by the engagement spring 143 through the friction force between the collecting tube 2 and the plug hole;
preferably, the upper end of the insertion hole is rotatably connected with a rotating ring, and a rubber ring which is in contact with the collection tube 2 is arranged on the inner side surface of the rotating ring so that the collection tube 2 cannot be separated from the insertion hole (not shown in the figure);
when the cover body is used, the cover body covers the collecting tube 2, the engagement ring 141 is engaged with the cover body, at the moment, the collecting tube 2 rotates, the cover body cannot rotate due to the cooperation of the guide rod 142 and the engagement ring 141, the cover body is connected to the collecting tube 2 in a threaded mode and gradually moves downwards, and along with the downward movement of the cover body, the engagement ring 141 and the guide rod 142 gradually move downwards and press the engagement spring 143, so that the cover body is sealed with the collecting tube 2 in a threaded mode.
In this embodiment, the sealing cover 13 includes an outer ring 131, an inner cover 132 connected to the outer ring 131 through a bearing, a mounting ring 136, a discharging ring 133, and a cover feeding assembly 11 disposed at the center of the bottom of the inner cover 132, the outer ring 131 is screwed to the storage box 1, and the center of the mounting ring 136 is concentric with the center of the inner cover 132;
the inner cover 132 is provided with the annular groove 12, the mounting ring 136 is adsorbed on the inner cover 132 and the cover feeding assembly 11 through magnetic force to form a cover body groove, the cover body is annularly arranged in the cover body groove, wherein the opening of the cover body arranged in the cover body groove faces downwards, the groove depth of the cover body groove is the same as the height of the cover body, one end of the mounting ring 136 is provided with a notch, a pressing assembly 10 positioned in the annular groove 12 is arranged in the notch, the pressing assembly 10 is electrically connected with the control main board 9, the cover feeding assembly 11 can feed the cover body in the cover body groove into the pressing assembly 10, and the pressing assembly 10 can press the cover body down onto one of the collecting pipes 2;
the inner cover 132 is provided with a sampling port 16, the distance between the sampling port 16 and the pressing component 10 is the same as the distance between the adjacent collecting pipes 2, and a sealing plug 17 is inserted into the sampling port 16;
the discharging ring 133 is placed on the storage box 1, the lower side surface of the inner cover 132 is abutted against the discharging ring 133, the discharging ring 133 is provided with a port corresponding to the collecting pipe 2, and the cover body can pass through the port on the discharging ring 133;
when the cotton swab is used, a cover body is placed in the annular groove 12, then the mounting ring 136 is magnetically adsorbed on the inner cover 132 and the cover conveying assembly 11, the cover conveying assembly 11 conveys the cover body into the pressing assembly 10, then the outer ring 131 is in threaded connection with the storage box 1, the cotton swab is installed and installed at the moment, when sampling is needed, the sealing plug 17 is taken down, the sampling part of the cotton swab is placed into the sampling tube 2 from the sampling port 16, the sealing plug 17 is blocked in the sampling port 16, at the moment, sampling is finished, the inner cover 132 is rotated, the inner cover 132 moves the pressing assembly 10 above the sampling tube 2 after sampling is finished, the pressing assembly 10 presses the cover body onto the sampling tube 2 and gradually moves downwards along with rotation of the sampling tube 2, after the cover body is installed, the pressing assembly 10 is reset, and the cover conveying assembly 11 conveys the other cover body into the pressing assembly 10.
In this embodiment, the cap feeding assembly 11 includes a cylinder located at the center of the lower side of the inner cap 132, a disc integrally formed at the center of the lower side of the cylinder, a return spring 111 sleeved on the cylinder, and an extrusion plate 113 located in the cap groove, the mounting ring 136 is magnetically adsorbed on the disc, one end of the return spring 111 is fixed on the cylinder, a space is provided between the mounting ring 136 and the inner cap 132 to form a sliding groove, the other end of the return spring 111 passes through the sliding groove and is connected to the extrusion plate 113 through a connecting plate, a limit assembly 18 located on the inner cap 132 is provided on one side of the extrusion plate 113, and when the extrusion plate 113 rotates to the maximum angle, the limit assembly 18 limits the extrusion plate 113;
the bottom of the disc is connected with a connector 134 through a conductive slip ring, the upper side surface of the storage box 1 is provided with an interface electrically connected with the control main board 9, the connector 134 is inserted in the interface, and the conductive slip ring is electrically connected with the pressing component 10;
when the cover is used, the extrusion plate 113 is rotated clockwise, in the rotation process, the extrusion plate 113 passes through the limiting component 18, the extrusion plate 113 is loosened at the moment, the limiting component 18 limits the position of the extrusion plate 113, then a cover body is placed into the annular groove 12 between the lower pressing component 10 and the extrusion plate 113, after the cover body is placed, the mounting ring 136 is magnetically fixed, then the limiting component 18 is opened, the limiting component 18 does not limit the extrusion plate 113 any more, the return spring 111 drives the extrusion plate 113 to extrude on the cover body, and after the lower pressing component 10 moves down one cover body and resets, the extrusion plate 113 drives the rest cover bodies to convey the cover body to the lower pressing component 10 in the anticlockwise direction.
In this embodiment, the limiting component 18 includes a pressing plate 184 located on the upper side of the inner cap 132, a polygonal barrel 182, and a polygonal rod 181 inserted into the polygonal barrel 182, the upper side of the inner cap 132 is provided with a polygonal hole, the polygonal barrel 182 is inserted into the polygonal hole and fixed by glue, the upper side of the polygonal barrel 182 is integrally formed with a limiting ring, the inner ring diameter of the limiting ring is smaller than the side length of the upper side of the polygonal rod 181, so that the polygonal rod 181 cannot move upwards to be separated from the polygonal barrel 182, the pressing plate 184 is connected with the polygonal rod 181 through a spring, the spring can pass through the inner ring of the limiting ring, a pressing sub-buckle 183 is glued on the pressing plate 184, a pressing female buckle pressed and locked with the pressing sub-buckle 183 is glued on the inner cap 132, one end of the polygonal rod 181 located in the sliding groove is provided with a chamfer, the end face of the connecting plate is right triangle, and the chamfer of the connecting plate faces the chamfer, so that the pressing plate 113 can push the polygonal rod 181 to move upwards when rotating clockwise;
when the pressing plate is used, the pressing sub-buckle 183 is pressed and locked with the pressing female buckle, the lower end of the polygonal rod 181 is located in the sliding groove, when the pressing plate 113 is rotated clockwise, the connecting plate pushes the polygonal rod 181 to move upwards until the connecting plate passes through the polygonal rod 181, then the pressing plate 113 is loosened, the right-angle edge of the connecting plate is abutted against the polygonal rod 181 to achieve limiting of the pressing plate 113, when the cover body is installed, the pressing plate 184 is pressed, the pressing sub-buckle 183 is unlocked with the pressing female buckle, then the pressing plate 184 is moved upwards, the pressing plate 184 drives the polygonal rod 181 to move upwards through a spring, so that the polygonal rod 181 is retracted into the polygonal cylinder 182, the connecting plate is not limited any more, and the return spring 111 drives the pressing plate 113 to press the cover body.
In this embodiment, the pressing component 10 includes an orifice plate located at a notch of the mounting ring 136, a permanent magnet 104 located above the orifice plate, a guide cylinder 102 located on the permanent magnet 104, and an electromagnet 101 located above the guide cylinder 102, the orifice plate is fixed on the inner cover 132, the annular groove 12 is provided with a blind hole for fixing the electromagnet 101, when the electromagnet 101 attracts the permanent magnet 104 magnetically, the lower side surface of the permanent magnet 104 does not protrude out of the blind hole, the electromagnet 101 is electrically connected with a conductive slip ring, the orifice plate is provided with a discharge hole 137, the permanent magnet 104 is located above the discharge hole 137, one side of the discharge hole 137 is provided with a limiting plate 105 located on the annular groove 12, so that when the cover body contacts with the limiting plate 105, the cover body can move downwards from the discharge hole 137;
at least three strip-shaped grooves are vertically formed in the side surface of the guide cylinder 102 and the side surface of the ring groove 12, and balls are arranged in the strip-shaped grooves, so that the guide cylinder 102 can only move up and down;
an elastic ring 103 is glued in the discharge hole 137, and the inner ring of the elastic ring 103 is smaller than the diameter of the cover body;
the sampling port 16 is positioned on one side of the limiting plate 105 away from the permanent magnet 104;
when the cover body needs to be installed, the magnetic poles of the control electromagnet 101 and the permanent magnet 104 are the same as those of the opposite side surfaces of the electromagnet 101, the permanent magnet 104 moves downwards and pushes the cover body to move downwards, the cover body passes through the elastic ring 103 and is abutted against the threads of the collecting pipe 2, after the cover body is fixed on the collecting pipe 2 through the threads, the magnetic poles of the control electromagnet 101 and the permanent magnet 104 are opposite, the permanent magnet 104 is magnetically attracted on the electromagnet 101, at the moment, the permanent magnet 104 enters the blind hole, the return spring 111 drives the cover body to contact with the limiting plate 105 through the extrusion plate 113, and at the moment, the cover body is positioned below the permanent magnet 104, so that secondary cover body installation can be performed.
In this embodiment, the outer side surface of the inner cover 132 contacts with the inner side surface of the storage box 1, the contact side surfaces are provided with placing grooves 1321, trigger electrode plates 15 corresponding to the number and the positions of the collection tubes 2 are arranged in the placing grooves 1321 of the storage box 1, contact electrode plates 1322 corresponding to the positions of the permanent magnets 104 are arranged in the placing grooves 1321 of the inner cover 132, the contact electrode plates 1322 are electrically connected with a conductive slip ring, and the trigger electrode plates 15 are electrically connected with the control main board 9;
when in use, when the contact electrode plate 1322 is contacted with the trigger electrode plate 15, the control main board 9 receives an electric signal and controls the electromagnet 101 to be the same as the magnetic pole of the permanent magnet 104, at the moment, the permanent magnet 104 pushes the cover body to move downwards and prop against the discharging ring 133, when the cover body corresponds to the opening on the discharging ring 133, the cover body passes through the opening cover on the discharging ring 133 and is arranged on the collecting tube 2, after 5-10 seconds, the control main board 9 automatically controls the current switching of the electromagnet 101 to enable the magnetic pole of the electromagnet 101 to be switched to be opposite to the magnetic pole of the permanent magnet 104, wherein in 5-10 seconds of power on, the motor 7 works to drive the fluted disc 5 to rotate, and the rotating angle of the fluted disc 5 is determined based on the number of the collecting tubes 2.
In this embodiment, the inner cover 132 is further provided with a warning light 19, and the warning light 19 is electrically connected to the conductive slip ring, and when the contact electrode plate 1322 contacts the trigger electrode plate 15, the control main board 9 controls the warning light 19 to emit light when power is applied.
Although the present invention has been described with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements and changes may be made without departing from the spirit and principles of the present invention.

Claims (10)

1. The vaccine derived poliovirus neutralization antigen mutation site information analysis processing system is characterized in that: the system comprises an analysis processing module, a virus module and a region data acquisition module, wherein the analysis processing module is respectively connected with the virus module and the region data acquisition module, the analysis processing module comprises an annotation module, a data analysis module, a display module, a cloud data storage module and a deep learning module, and the virus module comprises an incubation module, a virus detection module and a virus sampling module;
the data analysis module is used for comparing and analyzing data and judging whether immune escape is caused or not based on the result of the comparing and analyzing;
the cloud data storage module is used for realizing data storage by adopting a cloud database and can be connected with the Internet to acquire virus types and different types of data, wherein the cloud data storage module can autonomously classify the viruses according to the different virus types acquired by the Internet;
the deep learning module adopts a neural network to realize deep learning, and the learning content is different types of data of the cloud data storage module and data detected by the virus module;
the display module displays data by adopting a display;
the annotation module is used for annotating and labeling based on the data displayed by the display module;
the incubation module incubates viruses by adopting virus incubation equipment;
the virus detection module detects viruses incubated by the incubation module and transmits detected data to the incubation data comparison module.
2. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system according to claim 1, wherein: the regional data acquisition module comprises a virus clinical data module and a regional data module;
the virus clinical data module adopts a camera to collect clinical image information of a patient, acquires clinical detection data of the patient by a hospital, and transmits the detection data into the data analysis module;
the regional data module is used for acquiring the local vaccine immune coverage rate and the local economic condition and transmitting the acquired data into the data analysis module.
3. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system according to claim 1, wherein: the virus sampling module comprises a cylindrical storage box, a plurality of collecting pipes arranged in the storage box, a sealing cover detachably connected to the upper side surface of the storage box, a control main board and lithium batteries electrically connected with the control main board, wherein the sealing cover is in sealing connection with the storage box, the collecting pipes are circularly distributed by taking the center of the circle of the upper side surface of the storage box as a center point, a driving component for driving the single collecting pipe to rotate is arranged at the bottom of the storage box, and the driving component is electrically connected with the control main board;
the sealing cover is provided with cover bodies with the same number as the collection tubes, the sealing cover can cover the cover bodies on the collection tubes, and when the cover bodies cover the collection tubes, the driving assembly drives the corresponding collection tubes to rotate so that the cover bodies are connected to the collection tubes in a threaded mode.
4. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system according to claim 3, wherein: the driving assembly comprises a rotary table positioned at the bottom of the collecting pipe, a gear, a motor and a fluted disc which are arranged at the bottom of the rotary table, the rotary table is rotationally connected to the storage box, a plurality of arc-shaped grooves are formed in the upper side surface of the rotary table, the circle centers of the arc-shaped grooves are concentric and positioned below the center of the bottom of the collecting pipe, and the bottom of the collecting pipe is provided with a protrusion which can be inserted into the arc-shaped grooves;
the bottom of the storage box is provided with a cavity, the gear and the fluted disc are positioned in the cavity, the fluted disc is connected in the cavity through a bearing, and the fluted disc is provided with meshing teeth meshed with the gear;
the motor is connected with the fluted disc, and the motor is electrically connected with the control main board.
5. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system of claim 4, wherein: the storage box is provided with a meshing assembly positioned at the outer side of the collection pipe, the meshing assembly comprises a plurality of guide rods vertically inserted into the storage box, a meshing ring arranged at the upper end of the guide rods and a meshing spring positioned between the meshing ring and the storage box, the storage box is internally provided with a guide groove, and the guide rods are inserted into the guide groove and cannot be separated from the guide groove;
the upper side surface of the meshing ring can be meshed with the cover body teeth, and the meshing ring is sleeved on the collecting pipe;
the engagement spring cannot push the collection tube upward.
6. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system of claim 5, wherein: the sealing cover comprises an outer ring, an inner cover rotationally connected to the outer ring, a cover feeding assembly arranged at the center of the bottom of the inner cover, a mounting ring and a discharging ring, wherein the outer ring is in threaded connection to the storage box, and the circle center of the mounting ring is concentric with the circle center of the inner cover;
the inner cover is provided with a ring groove, the mounting ring is detachably arranged on the inner cover and the cover feeding component to form a cover body groove, the cover body is annularly arranged in the cover body groove, the opening of the cover body arranged in the cover body groove faces downwards, the groove depth of the cover body groove is the same as the height of the cover body, one end of the mounting ring is provided with a notch, a pressing component positioned in the ring groove is arranged in the notch, the pressing component is electrically connected with the control main board, the cover feeding component can feed the cover body in the cover body groove into the pressing component, and the pressing component can press the cover body down to one of the collecting pipes;
the inner cover is provided with a sampling port, the distance between the sampling port and the pressing component is the same as the distance between the adjacent collecting pipes, and a sealing plug is inserted into the sampling port;
the discharging ring is placed on the storage box, the lower side face of the inner cover is abutted against the discharging ring, the discharging ring is provided with a port corresponding to the collecting pipe, and the cover body can pass through the port on the discharging ring.
7. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system according to claim 6, wherein: the cover conveying assembly comprises a cylinder positioned at the center of the lower side surface of the inner cover, a disc arranged at the center of the lower side surface of the cylinder, a return spring sleeved on the cylinder and an extrusion plate positioned in the cover body groove, one end of the return spring is fixed on the cylinder, a gap is arranged between the mounting ring and the inner cover to form a sliding groove, the other end of the return spring passes through the sliding groove and is connected onto the extrusion plate, one side of the extrusion plate is provided with a limiting assembly positioned on the inner cover, and when the extrusion plate rotates to the maximum angle, the limiting assembly limits the extrusion plate;
the disc bottom is connected with the connector through electrically conductive sliding ring, deposit the case upside and be provided with the interface of being connected with the control mainboard electricity, connect grafting in the interface, electrically conductive sliding ring electricity is connected and is pushed down the subassembly.
8. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system of claim 7, wherein: the limiting component comprises a pressing plate located on the upper side of the inner cover, a polygonal barrel penetrating through the inner cover in a sealing mode and a polygonal rod inserted into the polygonal barrel, wherein the polygonal rod cannot be separated from the polygonal barrel when moving upwards, the pressing plate is connected with the polygonal rod through a spring, a pressing sub-buckle is arranged on the pressing plate, a pressing female buckle which is locked by pressing the pressing sub-buckle is arranged on the inner cover, and a chamfer is arranged at one end of the polygonal rod located on the sliding groove, so that the pressing plate can push the polygonal rod to move upwards when rotating clockwise.
9. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system of claim 8, wherein: the pressing component comprises a pore plate positioned at a notch of the mounting ring, a permanent magnet positioned above the pore plate, a guide cylinder positioned on the permanent magnet and an electromagnet positioned above the guide cylinder, wherein the pore plate is fixed on the inner cover, a blind hole for fixing the power supply magnet is formed in the annular groove, when the permanent magnet is attracted by the electromagnetic ferromagnetic, the blind hole is not protruded from the lower side surface of the permanent magnet, and the electromagnetic ferromagnetic is connected with the electric conduction device
The sliding ring is provided with a discharge hole, the permanent magnet is positioned above the discharge hole, and a limiting plate positioned on the annular groove is arranged on one side of the discharge hole, so that the cover body can move downwards from the discharge hole when the cover body is in contact with the limiting plate;
at least three strip-shaped grooves are vertically formed in the side face of the guide cylinder and the side face of the annular groove, and balls are arranged in the strip-shaped grooves, so that the guide cylinder can only move up and down;
an elastic ring is arranged in the discharge hole, and the inner ring of the elastic ring is smaller than the diameter of the cover body;
the sampling port is positioned at one side of the limiting plate far away from the permanent magnet.
10. The vaccine-derived poliovirus neutralization antigen mutation site information analysis processing system according to claim 9, wherein: the inner cover is characterized in that the outer side face of the inner cover is in contact with the inner side face of the storage box, the contact side faces are provided with placing grooves, trigger electrode plates corresponding to the number and the positions of the collecting pipes are arranged in the placing grooves of the storage box, contact electrode plates corresponding to the positions of the permanent magnets are arranged in the placing grooves of the inner cover, the contact electrode plates are electrically connected with the conductive slip ring, and the trigger electrode plates are electrically connected with the control main board.
CN202310451303.4A 2023-04-24 2023-04-24 Vaccine derived poliovirus neutralization antigen mutation site information analysis processing system Pending CN116486905A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310451303.4A CN116486905A (en) 2023-04-24 2023-04-24 Vaccine derived poliovirus neutralization antigen mutation site information analysis processing system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310451303.4A CN116486905A (en) 2023-04-24 2023-04-24 Vaccine derived poliovirus neutralization antigen mutation site information analysis processing system

Publications (1)

Publication Number Publication Date
CN116486905A true CN116486905A (en) 2023-07-25

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Country Status (1)

Country Link
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117427560A (en) * 2023-12-20 2024-01-23 江苏南理范群装备科技有限公司 Boiling granulator preheats structure

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117427560A (en) * 2023-12-20 2024-01-23 江苏南理范群装备科技有限公司 Boiling granulator preheats structure
CN117427560B (en) * 2023-12-20 2024-03-15 江苏南理范群装备科技有限公司 Boiling granulator preheats structure

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