CN116457060A - Target weight determination method, device and radiotherapy system - Google Patents

Abstract

A target weight determination method, device and radiotherapy system belong to the technical field of radiotherapy. Because for each target area, the weight determination device of the target point can determine the corresponding weight adjustment value based on the target dose of the beam that each target point needs to receive in the multiple target points, and automatically adjust the weight adjustment value based on the weight adjustment value. The initial weight of each target point in the target area is used to determine the target weight of each target point, so not only the efficiency of determining the target point weight is high, but also the reliability is good.

Description

Target weight determination method, device and radiotherapy system technical field

The present disclosure relates to the technical field of radiotherapy, and in particular to a target weight determination method, device and radiotherapy system.

Background technique

Radiation therapy is an effective means of treating tumors with radiation beams, and making a treatment plan is one of the essential steps in the entire radiation therapy process. When formulating a treatment plan, a target volume is generally set based on the location of the tumor, and multiple targets are set within the target volume. Correspondingly, in order to ensure the safety and reliability of subsequent radiation therapy, for each target, the treatment plan needs to include: the weight of the target relative to other targets, which affects the radiation of the target duration.

In related technologies, generally, the treating physician flexibly adjusts and sets the weight of each target point according to the total dose of the beam required for treatment, and the position and size of each target point.

However, the weight setting method adopted in the related art not only has low efficiency, but also has poor reliability.

Contents of the invention

The present disclosure provides a target weight determination method, device and radiotherapy system, which can solve the problems of low efficiency and poor reliability of the weight setting method in the related art. Described technical scheme is as follows:

On the one hand, a method for determining the weight of a target is provided, the method comprising:

determining an initial weight for each of a plurality of target points, wherein the plurality of target points are located in the same target area or in a plurality of different target areas;

determining a target dose of radiation to be received at each of said targets;

For each of the target areas, based on the target dose of the radiation required to be received by each of the multiple target points in the target area, the weight adjustment value of the target area is determined, and the weight adjustment The value is the sum of the dose values contributed by each target point in the target area to the maximum dose point in the target area;

For each target area, based on the weight adjustment value of the target area, the initial weight of each target point in the target area is adjusted according to the target ratio, and the weight of each target point in the target area is obtained. A target weight, where the target weight is used to indicate the irradiation time for irradiating the target point with the beam.

Optionally, the multiple target points are located in multiple different target areas; for each of the target areas, based on the target of the beam that each of the multiple target points needs to receive Dose, determining the weight adjustment value of the target area, including:

determining the dose contribution coefficients of all the target points in the target area to each of the other target areas based on the target dose of the beam that each of the target points in the target area needs to receive;

determining the total dose of the beam that can be received by the maximum dose point in the target area based on the target dose of the beam that each of the multiple target points needs to receive;

Based on the dose contribution coefficient of each of the multiple target areas to each of the other target areas, and the maximum dose point that can be received by each of the multiple target areas For the total dose, the weight adjustment value for the target area is determined.

Optionally, determining the dose contribution coefficients of all the target points in the target area to each other target area based on the target dose of the beam that each target point in the target area needs to receive, include:

Based on the target dose of the beam that each target point in the target area needs to receive, the dose contribution value of the target area to each other target area is determined, and the dose contribution value refers to the dose contribution value of the target area in the target area. The sum of the dose values contributed by each target point to the maximum dose point in each other target area;

For each of the other target areas, based on the weight adjustment value of the target area and the dose contribution value of the target area to the other target area, determine the contribution of all the target points in the target area to the other target area The dose contribution coefficient of the region.

Optionally, the doses of all the target points in the target area to the other target areas are determined based on the weight adjustment value of the target area and the dose contribution value of the target area to the other target area Contribution factors, including:

The ratio of the weight adjustment value of the target area to the dose contribution value of the target area to the other target area is determined as the dose contribution coefficient of all the target points in the target area to the other target area.

Optionally, determining the beam that can be received by the point with the maximum dose in the target area based on the target dose of the beam that each of the target points in the target area of the multiple target points needs to receive total dose, including:

Based on the target dose of the radiation required to be received by each of the target points in each of the multiple target points, determine the impact of each of the multiple target points on the target area The initial dose of the beam contributed by the point of maximum dose in ;

For each target area, the initial dose of the beam contributed by each of the target points in the multiple target areas to the maximum dose point in the target area is added to obtain the maximum dose point in the target area. The total dose of the beam received.

Optionally, based on the dose contribution coefficient of each of the target areas in the multiple target areas to each of the other target areas, and the maximum dose in each of the target areas in the multiple target areas The total dose that can be received by the point determines the weight adjustment value of the target area, including:

determining a weight reference value based on the dose contribution coefficient of each of the multiple target areas to each of the other target areas;

Based on the dose contribution coefficient of each of the multiple target areas to each of the other target areas, and the maximum dose point that can be received by each of the multiple target areas Total dose, determine the weight alternative value of the target area;

A weight adjustment value of the target area is determined based on the weight reference value and the weight candidate value of the target area.

Optionally, the weight reference value D satisfies:

Wherein, Fij is the dose contribution coefficient of each target point in the i-th target area to the j-th target area, i, j and n are all positive integers, and i and j are all less than or equal to n, n is the total number of multiple target areas.

Optionally, the weight alternative value Di of the i-th target area satisfies:

Wherein, Dpi is the total dose of the beam that can be received by the maximum dose point in the i-th target area.

Optionally, determining the weight adjustment value of the target area based on the weight reference value and the weight candidate value of the target area includes: combining the weight candidate value of the target area with the weight reference value The ratio of is determined as the weight adjustment value of the target area.

Optionally, the determining the initial weight of each of the multiple target points and determining the initial weight of each of the multiple target points includes:

For each target area, a gradient algorithm or a neural network algorithm is used to determine the initial weight of each target point in the target area, so that the total dose of the beams irradiated to the target area is greater than or equal to the dose threshold.

In another aspect, a device for determining the weight of a target is provided, the device comprising:

A first determination module, configured to determine the initial weight of each of the multiple target points, wherein the multiple target points are located in the same target area or in multiple different target areas;

The second determination module is used to determine the target dose of the beam that each target point needs to receive;

The third determination module is configured to determine, for each target area, the weight adjustment value of the target area based on the target dose of the beam that each of the multiple target points needs to receive, The weight adjustment value is the sum of the dose values contributed by each target point in the target area to the maximum dose point in the target area;

An adjustment module, for each target area, based on the weight adjustment value of the target area, adjust the initial weight of each target point in the target area according to the target ratio, and obtain the weight of each target point in the target area. A target weight of the target point, where the target weight is used to indicate the irradiation duration of using the beam to irradiate the target point.

In yet another aspect, a host is provided, the host includes: a processor and a memory, and instructions are stored in the memory, and the instructions are loaded and executed by the processor to achieve the target as described in the above aspect weight determination method.

In another aspect, a storage medium is provided, the storage medium stores instructions, and when the storage medium runs on the processing component, the processing component executes the method for determining the weight of the target point as described in the above aspect.

In another aspect, a radiotherapy system is provided, the radiotherapy system includes: a patient support device and a host, the host is connected to the patient support device, and the host is used to adjust the position of the patient support device;

Wherein, the host includes the device described in the above aspect, or the host is the host described in the above aspect.

The technical solutions provided by the embodiments of the present disclosure have at least the following beneficial effects:

Embodiments of the present disclosure provide a target point weight determination method, device and radiotherapy system. Because for each target area, the weight determination device of the target point can determine the corresponding weight adjustment value based on the target dose of the beam that each target point needs to receive in the multiple target points, and automatically adjust the weight adjustment value based on the weight adjustment value. The initial weight of each target point in the target area is used to determine the target weight of each target point, so not only the efficiency of determining the target point weight is high, but also the reliability is good.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present disclosure.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present disclosure, the drawings that need to be used in the description of the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present disclosure. For those skilled in the art, other drawings can also be obtained based on these drawings without creative effort.

FIG. 1 is a schematic structural diagram of a radiotherapy system provided by an embodiment of the present disclosure;

Fig. 2 is a flowchart of a target weight determination method provided by an embodiment of the present disclosure;

Fig. 3 is a flowchart of another target weight determination method provided by an embodiment of the present disclosure;

Fig. 4 is a flowchart of a method for determining a dose contribution coefficient provided by an embodiment of the present disclosure;

Fig. 5 is a flowchart of a method for determining the total dose of the beam that can be received by the maximum dose point in the target area provided by an embodiment of the present disclosure;

Fig. 6 is a flow chart of a method for determining a weight adjustment value of a target volume provided by an embodiment of the present disclosure;

Fig. 7 is a block diagram of a device for determining a target provided by an embodiment of the present disclosure;

Fig. 8 is a block diagram of a third determining module provided by an embodiment of the present disclosure;

Fig. 9 is a schematic diagram of an optional structure of a host provided by an embodiment of the present disclosure.

By means of the above-mentioned drawings, certain embodiments of the present disclosure have been shown and will be described in more detail hereinafter. These drawings and written description are not intended to limit the scope of the disclosed concept in any way, but to illustrate the disclosed concept for those skilled in the art by referring to specific embodiments.

Detailed ways

In order to make the purpose, technical solutions and advantages of the embodiments of the present disclosure clearer, the embodiments of the present disclosure will be further described in detail below in conjunction with the accompanying drawings.

Fig. 1 is a schematic structural diagram of a radiotherapy system provided by an embodiment of the present disclosure. As shown in FIG. 1 , the system may include: a patient support device 01 , a host 02 and a radiation source device 03 .

Optionally, the patient supporting device 01 may be a treatment bed as shown in FIG. 1 , and of course, it may also be other devices for supporting patients such as a treatment chair. The host 02 can be a computer device or a server. The radiation source device 03 can emit beams to a target object (such as a tumor) to achieve treatment on the target object. If the system is a Gamma Knife treatment system, the radiation source of the radiation source device 03 can be cobalt-60. Among them, the treatment principle of Gamma Knife treatment is: Gamma rays generated by cobalt-60 are geometrically focused on the lesion (also called the target point), and the human tissue in the target point is destroyed at one time to achieve the purpose of treating the disease.

Wherein, the host computer 02 may establish a communication connection with the patient support device 01 and the radiation source device 03, for example, a wired connection as shown in FIG. 1 , and of course, a wireless connection. The host 02 can flexibly control the position of the patient support device 01 and control the working state of the radiation source device 03 . For example, during radiotherapy, the host 02 can first control the patient support device 01 to move the patient into the radiation source device 03, and then control the radiation source device 03 to emit beams to achieve precise treatment for the patient.

In addition, in order to ensure the safety and reliability of radiation therapy and to obtain a satisfactory therapeutic effect, before radiation therapy, a treatment plan will be made for the patient. If it is Gamma Knife treatment, the treatment plan can also be called Gamma Knife Knife treatment plan. Before formulating a treatment plan, a reference image of the target object is generally obtained for formulating the treatment plan. Optionally, the reference image may be a computerized tomography (computed tomography, CT) image, or a nuclear magnetic resonance (magnetic resonance, MR) image. The treating physician can then reliably formulate a treatment plan based on the size, shape, and surrounding tissue of the target object displayed in the CT or MR image.

When formulating a treatment plan, the treating physician generally sets one or more target volumes based on the obtained reference images, and sets one or more target points in each target volume. During subsequent radiation therapy, the beam can be Irradiate to the set target point, so as to complete the reliable treatment of the target object. In addition, the dose of radiation received by each target is generally determined based on the total dose of radiation required to treat the target, because the duration of beam irradiation to a target affects the dose received by the target. The dose of the beam, therefore, determines the duration of irradiation of the beam to each target. In order to reflect the irradiation duration, the weight parameter is generally used as a reference. For example, for each target point, the weight of the target point relative to other target points can be directly proportional to the irradiation duration of the target point. Thus, when formulating a treatment plan, it is necessary to flexibly adjust to set the weight of each target point relative to other targets, that is, the relative weight of each target point.

In related technologies, the relative weights of targets are generally adjusted and set manually. This method is not only time-consuming and labor-intensive, but also has low efficiency, and because each target has a dose contribution to each target area, it is not suitable for multiple target areas. , adjusting the weight of the target point in a target area may affect the dose of the beam received by other target areas, so that it will affect the weight of the target point in other target areas, and in turn, it will affect the dose of the beam in the target area The weight of the target point, and so on. The embodiment of the present disclosure provides a method for automatically determining the weight of the target point, which can solve the technical problems in the weight setting method of the related art, and correspondingly, can improve the efficiency and quality of formulating the treatment plan.

FIG. 2 is a flow chart of a method for determining the weight of a target provided by an embodiment of the present disclosure, which can be applied to the host 02 shown in FIG. 1 . As shown in Figure 2, the method may include:

Step 201. Determine the initial weight of each target point among multiple target points.

Wherein, the multiple target points may be located in the same target area or may be located in multiple different target areas.

Optionally, the host may first determine the initial weight of each target point, and the initial weight of each target point may refer to an initial relative weight of the target point relative to other targets in the plurality of target points.

Step 202, determining the target dose of the radiation required to be received by each target point.

After determining the initial weight of each target point, the host computer can reliably determine the target dose of the beams to be received by each target point based on the total dose of the beams to be received by the multiple target points through dose calculation.

Step 203 , for each target area, based on the target dose of the radiation required to be received by each target point among the plurality of target points, determine the weight adjustment value of the target area.

Wherein, the weight adjustment value may be the sum of dose values contributed by each target point in the target area to the maximum dose point in the target area.

Optionally, for each target area, after the host determines the target dose that each target point in each target area needs to receive, it can further calculate the weight adjustment value corresponding to the target area based on the determined target dose , the weight adjustment value can be used as a reference for subsequent determination of the weight of the target.

Step 204 , for each target area, based on the weight adjustment value of the target area, adjust the initial weight of each target point in the target area according to the target ratio, and obtain the target weight of each target point in the target area.

Wherein, the target weight can be used to indicate the irradiation duration of using the beam to irradiate the target point. For example, for each target point, the target weight of the target point is proportional to the irradiation time of the beam irradiating the target point. That is, the greater the target weight of the target point, the longer the beam irradiates the target point, and correspondingly, the greater the beam dose that the target point can receive. Conversely, the smaller the target weight of the target point is, the shorter the beam irradiates the target point, and correspondingly, the smaller the beam dose that the target point can receive. Moreover, the target weight of each target point may also refer to the target weight of the target point relative to other target points in the plurality of target points.

Optionally, for each target area, after the host computer determines the weight adjustment value of the target area, it can adjust the initial weight of each target point in the target area according to the target ratio, and then obtain the weight of each target point in the target area. The target weight for the point.

To sum up, the embodiment of the present disclosure provides a method for determining the weight of a target. For each target area, the corresponding weight adjustment value can be determined based on the target dose of the beam that each target point needs to receive in multiple target points, and each target point in the target area can be automatically adjusted based on the weight adjustment value The initial weight of each target point is used to determine the target weight of each target point, so not only the efficiency of determining the target point weight is high, but also the reliability is good.

Fig. 3 is a flow chart of a method for determining the weight of a target provided by an embodiment of the present disclosure, which can be applied to the host 02 shown in Fig. 1 . As shown in Figure 3, the method may include:

Step 301. Determine the initial weight of each target point among multiple target points.

Wherein, for each target point, the initial weight of the target point may refer to the relative initial weight of the target point relative to other target points. In this way, it can also be determined that for a scenario where the entire treatment plan includes only one target point, there is no concept of weight for this target point.

When formulating a treatment plan, the treating physician can first set one or more target volumes based on the acquired reference images (such as CT images or MR images) of the patient, and then can continue to be controlled by the treating physician or a device specially used to set the target points. One or more target points are reasonably set (also referred to as placement) in each target area. That is, the above multiple targets may refer to multiple targets located in the same target area, or may also refer to multiple targets located in different target areas. The following embodiments all take the multiple target points located in different multiple target areas as an example for illustration.

For each target area, starting from placing the mth target point in the target area, each time a target point is placed, the host computer can set each target point in the target area (including the mth target point and Each target point that has been placed before the mth target point) performs a weight adjustment, and after all the target points are placed in the target area, the initial weight of each target point can be determined. Wherein, m may be an integer greater than 1.

Optionally, for each target area, the host computer can use optimization algorithms such as gradient algorithm or neural network algorithm to determine the initial weight of each target point in the target area, so that the total dose of the beam irradiated to the target area is greater than or equal to the dose threshold. That is, for each target area, starting from placing the m-th target point, the host computer can take the target area surrounded by the prescription measurement line as the purpose of being larger than the range threshold for each target point, that is, the target For the purpose of maximizing the range of radiation dose received by the region, the above optimization algorithm is used to automatically adjust to determine the initial weight of each target point that has been placed.

Wherein, if the target area is a three-dimensional area, the range of the target area surrounded by the prescription measurement line may refer to the volume of the target area surrounded by the prescription dose line. If the target area is a two-dimensional plane area, the range of the target area surrounded by the prescription measurement line may refer to the area of the target area surrounded by the prescription dose line.

Step 302. Determine the target dose of the beam that each target point needs to receive.

In the embodiment of the present disclosure, after the host computer determines the initial weight of each target point among the multiple target points, it can further complete the dose calculation for each target point.

Optionally, the host may pre-store the total dose of beams required for treatment. After determining the initial weight of each target point, the host may calculate the total dose of each target based on the total dose and the initial weight of each target. The target dose of the beam that a target needs to receive.

Step 303. For each target area, based on the target dose of the beam that each target point in the target area needs to receive, determine the dose contribution coefficients of all target points in the target area to each other target area.

Since each target point contributes to the final dose of the beam received by each target area, after determining the target dose of the beam that each target point needs to receive, the host can further calculate and determine each target area Each target point in , that is, the dose contribution coefficient of all target points to each other target area, that is, the dose contribution coefficient of each target area to each other target area.

For example, if three target areas are included, for the first target area, determining the dose contribution coefficients of all target points in the target area to each other target area may refer to: determining the contribution of each target point in the target area to The dose contribution coefficient of the second target area, and determining the dose contribution coefficient of each target point in the target area to the third target area.

As an example, Fig. 4 is a flowchart of a method for determining a dose contribution coefficient provided by an embodiment of the present disclosure. As shown in Figure 4, the method may include:

Step 3031 , for each target area, based on the target dose of the beam that each target point in the target area needs to receive, determine the dose contribution value of the target area to each other target area.

Wherein, for each target area, in addition to the target point, the target area generally includes a plurality of other points (which can be represented by pixels), and among the plurality of other points, there is a finally received radiation dose of the largest point, the point of maximum dose. The dose contribution value of the target area to each other target area may refer to the sum of the dose values contributed by each target point in the target area to the maximum dose point in each other target area.

Optionally, for each target area, the host can first determine the maximum dose of each target point in the target area to another target area based on the target dose of the beam that each target point in the target area needs to receive. The dose value contributed by the point. Then, the host can accumulate the dose values contributed by each target point in the target area to the maximum dose point in another target area, so as to obtain the dose contribution value of the target area to another target area.

Step 3032 , for each other target area, based on the weight adjustment value of the target area and the dose contribution value of the target area to other target areas, determine the dose contribution coefficients of all the target points in the target area to other target areas.

Optionally, for one target area and another other target area, the host may determine the ratio of the weight adjustment value of the one target area to the dose contribution value of the one target area to the other other target area as the one target area The dose contribution coefficient of each target point in a region to another target region.

Wherein, the weight adjustment value of each target area may refer to the sum of the dose values contributed by each target point in the target area to the maximum dose point in the target area. That is to say, for one target area and another other target area, the host can use the sum of the dose values contributed by each target point in the one target area to its own maximum dose point, divided by the maximum dose value for another other target area. The sum of the dose values contributed by the dose point to obtain the dose contribution coefficient of the one target area to the other target area.

Step 304. For each target area, based on the target dose of the beam that each target point needs to receive among the multiple target points, determine the total dose of the beam that can be received by the point with the largest dose in the target area.

Wherein, for each target area, the total dose of the beam that can be received by the maximum dose point in the target area may refer to: among multiple target points set in multiple target areas, each target point is The sum of the dose values contributed by the maximum dose point in the target area. Correspondingly, the method shown in FIG. 5 can be used to determine the total dose of the beams that can be received by the maximum dose point in each target area. As shown in Figure 5, the method may include:

Step 3041, for each target area, based on the target dose of the radiation required to be received by each target point in the multiple target points, determine the contribution of each target point in the multiple target areas to the maximum dose point in the target area The initial dose of the beam.

Optionally, in the embodiment of the present disclosure, for each target area, the host computer can first determine the target dose of the beam that each target point needs to receive for each target point in all the set target points. The initial dose of the beam contributed by the point of maximum dose in .

Step 3042, for each target area, add up the initial dose of the beam contributed by each target point in the multiple target areas to the maximum dose point in the target area, and obtain the beam that can be received by the maximum dose point in the target area total dose.

Then, the host can accumulate the initial dose of the beam contributed by each target point in the target area with the maximum dose, so as to obtain the total dose of the beam that can be received by the point with the maximum dose in the target area.

Step 305, for each target area, based on the dose contribution coefficient of each target area in the multiple target areas to each other target area, and the total dose that can be received by the maximum dose point in each target area in the multiple target areas, Determine the weight adjustment value for this target volume.

For each target area, the dose contribution coefficient of the target area to other target areas may refer to: the dose contribution coefficients of all target points in the target area to other target areas. After determining the dose contribution coefficient of each target area to each other target area, and the total dose that can be received by the maximum dose point in each target area, the host computer can further calculate the target area based on the above parameters determined. The weight adjustment value for the zone. The weight adjustment value may be the sum of the dose values contributed by each target point in the target area to the maximum dose point in the target area.

Optionally, the dose contribution coefficient of each target point in each target area to each other target area, the total dose that can be received by the maximum dose point in each target area, and the weight adjustment value of each target area can satisfy The following formula:

Among them, Fij is the dose contribution coefficient of each target point in the i-th target area to the j-th target area, i, j and n are all positive integers, i and j are both less than or equal to n, and n is the dose contribution coefficient of multiple target areas. total. For example, F12 refers to the dose contribution coefficient of each target point in the first target area to the second target area, and the other principles are the same. Dpi is the total dose of the beam that can be received by the maximum dose point in the i-th target area, that is, the i-th target area contains the maximum dose of the beam received by all the target points in the multiple target points. dose. For example, Dp1 refers to the total dose of the beam that can be received by the maximum dose point in the first target area, and the same applies to the rest. Dmaxi is the weight adjustment value of the i-th target area, that is, the sum of the dose values of the beams contributed by each target point in the i-th target area to the maximum dose point in the i-th target area. For example, Dmax1 refers to the weight adjustment value of the first target area, and the same applies to others.

Based on the above formula (1), it can be determined that the host computer can determine the weight adjustment value of each target area through the weight adjustment value determination method shown in FIG. 6 . As shown in Figure 6, the method may include:

Step 3051: Determine weight reference values based on the dose contribution coefficients of each target area among the multiple target areas to each other target area.

Optionally, combined with the above formula (1), it can be determined that the weight reference value D can satisfy:

That is, in the embodiment of the present disclosure, the host may substitute the determined dose contribution coefficient of each target area to each other target area into the above formula (2) to calculate the weight reference value D.

For example, assuming that n is 5, that is, there are 5 target areas in total, the weight reference value D can satisfy:

Step 3052, for each target area, based on the dose contribution coefficient of each target area in the multiple target areas to each other target area, and the total dose that can be received by the maximum dose point in each target area in the multiple target areas, Determine the weight alternatives for this target area.

Optionally, combined with the above formula (1) and formula (2), it can be determined that the weight alternative value Di of the i-th target area can satisfy:

That is, in the embodiment of the present disclosure, the host can be based on the dose contribution coefficient Fij of each target area in the multiple target areas to each other target area, and the maximum dose point that can be received in each target area in the multiple target areas The total dose Dpi of the beam is substituted into the above formula (3), and the alternative weight value Di of the i-th target area is calculated.

For example, assuming that n is 5, that is, 5 target areas are included in total, then the first target area weight candidate value D1 to the fifth target area reference value D5 can satisfy the following formula:

Step 3053, for each target area, determine the weight adjustment value of the target area based on the weight reference value and the weight candidate value of the target area.

Optionally, for each target area, the host may determine the ratio of the weight candidate value of the target area to the weight reference value as the weight adjustment value of the target area.

For example, assuming that there are 5 target areas in total, for the first target area, the weight adjustment value Dmax1 of the target area may satisfy: Dmax1=D1/D. For the second target area, the weight adjustment value Dmax2 of the target area can satisfy: Dmax2=D2/D. For the third target area, the weight adjustment value Dmax3 of the target area can satisfy: Dmax3=D3/D. For the fourth target area, the weight adjustment value Dmax4 of this target area can satisfy: Dmax4=D4/D. For the fifth target area, the weight adjustment value Dmax5 of this target area can satisfy: Dmax5=D5/D. D1 to D5 and D can all be calculated based on the above corresponding formulas.

Step 306 , for each target area, based on the weight adjustment value of the target area, adjust the initial weight of each target point in the target area according to the target ratio, and obtain the target weight of each target point in the target area.

Wherein, the target weight of each target point may be used to indicate the irradiation duration of using the beam to irradiate the target point. For example, for each target point, the target weight of the target point is proportional to the irradiation time of the beam irradiating the target point. That is, the greater the target weight of the target point, the longer the beam irradiates the target point, and correspondingly, the greater the beam dose that the target point can receive. Conversely, the smaller the target weight of the target point is, the shorter the beam irradiates the target point, and correspondingly, the smaller the beam dose that the target point can receive. Moreover, the target weight of each target point may also refer to the target weight of the target point relative to other target points in the plurality of target points.

Optionally, in the embodiment of the present disclosure, for each target area, after determining the weight adjustment value of the target area, the host can further adjust the steps according to the target ratio (ie, uniform ratio) based on the weight adjustment value 301. Determine the initial weight of each target point in the target area to obtain the target weight of each target point in the target area. Wherein, the target ratio can be input into the host by the treating physician in real time, or it can also be a ratio parameter pre-stored in the host.

For example, for each target area, the host can increase or decrease the initial weight of each target point in the target area according to a uniform ratio, so that the adjusted dose contributed by each target point to the maximum dose point in the target area The sum of the values reaches the weight adjustment value for that target. That is, for each target area, based on the final adjusted target weight of each target point in the target area, the irradiation time of each target point can be controlled, so that the dose contributed by each target point to the maximum dose point in the target area can be The sum of the values reaches the weight adjustment value for that target.

It should be noted that the order of the steps in the target weight determination method provided by the embodiments of the present disclosure can be adjusted appropriately. For example, step 304 can be performed before step 303. Within the technical scope, any methods that can be easily thought of as changes should be included in the scope of protection of the present disclosure, and thus will not be repeated here.

To sum up, the embodiment of the present disclosure provides a method for determining the weight of a target. For each target area, the corresponding weight adjustment value can be determined based on the target dose of the beam that each target point needs to receive in multiple target points, and each target point in the target area can be automatically adjusted based on the weight adjustment value The initial weight of each target point is used to determine the target weight of each target point, so not only the efficiency of determining the target point weight is high, but also the reliability is good.

Fig. 7 is a block diagram of an apparatus for determining the weight of a target point provided by an embodiment of the present disclosure. This device can be applied to the host 02 shown in FIG. 1 . As shown in Figure 7, the device may include:

The first determination module 701 is configured to determine the initial weight of each target point in the multiple target points.

Wherein, the multiple target points may be located in the same target area or in multiple different target areas.

The second determination module 702 is configured to determine the target dose of the beam that each target point needs to receive.

The third determination module 703 is configured to, for each target area, determine the weight adjustment value of the target area based on the target dose of the radiation required to be received by each target point among the multiple target points.

Wherein, for each target area, the weight adjustment value of the target area may be the sum of the dose values contributed by each target point in the target area to the maximum dose point in the target area.

The adjustment module 704 is configured to, for each target area, adjust the initial weight of each target point in the target area according to the target ratio based on the weight adjustment value of the target area, to obtain the target weight of each target point in the target area.

Wherein, for each target point, the target weight of the target point is used to indicate the irradiation duration of using the beam to irradiate the target point.

Optionally, if multiple targets are located in multiple different target regions. Then as shown in FIG. 8, the third determining module 703 may include:

The first determining submodule 7031 is configured to determine the dose contribution coefficients of all target points in the target area to each other target area based on the target dose of the beam that each target point in the target area needs to receive.

The second determination sub-module 7032 is configured to determine the total dose of the beams that can be received by the maximum dose point in the target area based on the target dose of the beams that each target point needs to receive among the multiple target points.

The third determining submodule 7033 is configured to be based on the dose contribution coefficient of each target area in the multiple target areas to each other target area, and the total dose that can be received by the maximum dose point in each of the multiple target areas , to determine the weight adjustment value of the target area.

Optionally, the first determination submodule 7031 can be used for:

For each target area, based on the target dose of the beam that each target point in the target area needs to receive, the dose contribution value of this target area to each other target area is determined.

Wherein, the dose contribution value may refer to the sum of the dose values contributed by each target point in the target area to the maximum dose point in each other target area.

For each other target area, based on the weight adjustment value of the target area and the dose contribution value of this target area to other target areas, the dose contribution coefficients of all target points in this target area to other target areas are determined.

For example, the first determining submodule 7031 may determine the ratio of the weight adjustment value of the target area to the dose contribution value of the target area to other target areas as the dose contribution coefficient of all target points in the target area to other target areas.

Optionally, the second determining submodule 7032 can be used for:

For each target area, based on the target dose of the beam that each target point needs to receive in the multiple target points, determine the initial value of the beam that each target point in the multiple target points contributes to the maximum dose point in the target area dose.

The initial dose of the beam contributed by each target point in the multiple target areas to the maximum dose point in the target area is accumulated to obtain the total dose of the beam that can be received by the maximum dose point in the target area.

Optionally, the third determining submodule 7033 can be used for:

A weight reference value is determined based on the dose contribution coefficient of each target area among the multiple target areas to each other target area.

For each target volume, the target volume is determined based on the dose contribution coefficient of each of the multiple target volumes to each of the other target volumes, and the total dose that can be received at the point of maximum dose in each of the multiple target volumes. Alternative values for the weight of the zone.

Based on the weight reference value and the weight candidate value of the target area, the weight adjustment value of the target area is determined. For example, for each target area, the third determining submodule 7033 may determine the ratio of the weight candidate value of the target area to the weight reference value as the weight adjustment value of the target area.

Optionally, the weight reference value D can satisfy:

Among them, Fij is the dose contribution coefficient of each target point in the i-th target area to the j-th target area, i, j and n are all positive integers, i and j are both less than or equal to n, and n is the dose contribution coefficient of multiple target areas. total.

Optionally, the weight alternative value Di of the i-th target area can satisfy:

Wherein, Dpi may be the total dose of the beam that can be received by the maximum dose point in the i-th target area.

Optionally, the first determination module 701 may be used to:

For each target area, a gradient algorithm or a neural network algorithm is used to determine the initial weight of each target point in the target area, so that the total dose of beams irradiated to the target area is greater than or equal to the dose threshold.

To sum up, the embodiments of the present disclosure provide an apparatus for determining weights of targets. Because for each target area, the device can determine the corresponding weight adjustment value based on the target dose of the beam that each target point needs to receive in the multiple target points, and automatically adjust each target area in the target area based on the weight adjustment value. The initial weight of the target point is used to determine the target weight of each target point, so not only the efficiency of determining the target point weight is high, but also the reliability is good.

Regarding the apparatus for determining weights of target points in the above embodiments, the specific manner in which each module executes operations has been described in detail in the embodiments of the method, and will not be described in detail here.

Optionally, referring to FIG. 9 , in an embodiment of the present disclosure, the host 02 in the radiotherapy system shown in FIG. 1 may include: a processor and a memory. Wherein, instructions may be stored in the memory, and the instructions are loaded and executed by the processor to realize the method for determining the weight of the target as shown in FIG. 2 or FIG. 3 .

Optionally, an embodiment of the present disclosure also provides a storage medium, which can store instructions, and when the storage medium runs on the processing component, the processing component can execute the target as shown in FIG. 2 or FIG. 3 . Point weight determination method.

The above descriptions are only optional embodiments of the present disclosure, and are not intended to limit the present disclosure. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the embodiments of the present disclosure shall be included in the present disclosure. Within the protection scope of the embodiment.

Claims (14)

1. A method for determining the weight of a target, the method comprising:

   determining an initial weight for each of a plurality of targets, wherein the plurality of targets are located at the same target area or at a plurality of different target areas;

   determining a target dose of the beam to be received for each of the targets;

   for each of the target volumes, determining a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of target points, the weight adjustment value being a sum of dose values contributed by the respective ones of the target volumes to a maximum dose point in the target volume;

   And for each target area, adjusting the initial weight of each target point in the target area according to a target proportion based on the weight adjustment value of the target area to obtain the target weight of each target point in the target area, wherein the target weight is used for indicating the irradiation duration of irradiating the target point by using a beam.
2. The method of claim 1, wherein the plurality of targets are located at a plurality of different target areas; the determining, for each of the target volumes, a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of targets, comprising:

   determining a dose contribution factor of all of the targets in the target region to each other target region based on a target dose of the beam required to be received by each of the targets in the target region;

   determining a total dose of the beam receivable by a maximum dose point in the target region based on a target dose of the beam required to be received by each of the plurality of targets;

   a weight adjustment value for each of the plurality of targets is determined based on the dose contribution coefficient of the target to each of the other targets and a total dose that can be received by a maximum dose point in each of the plurality of targets.
3. The method of claim 2, wherein the determining a dose contribution coefficient of all of the targets in the target region to each other target region based on a target dose of the beam required to be received by each of the targets in the target region comprises:

   determining a dose contribution value of the target region to each other target region based on a target dose of the beam required to be received by each of the target points in the target region, the dose contribution value being a sum of dose values contributed by respective ones of the target regions to a maximum dose point in each other target region;

   for each of the other target volumes, determining a dose contribution coefficient of all of the targets in the target volume to the other target volumes based on the weight adjustment value of the target volume and the dose contribution value of the target volume to the other target volumes.
4. A method according to claim 3, wherein the determining a dose contribution coefficient of all the targets in the target region to the other target region based on the weight adjustment value of the target region and the dose contribution value of the target region to the other target region comprises:

   and determining the ratio of the weight adjustment value of the target area to the dose contribution value of the target area to the other target areas as the dose contribution coefficient of the target area to the other target areas.
5. The method of claim 2, wherein the determining the total dose of the beam receivable by the maximum dose point in the target region based on the target dose of the beam required to be received by each of the plurality of targets comprises:

   determining an initial dose of the beam contributed by each of the plurality of targets to a point of maximum dose in the target region based on a target dose of the beam required to be received by each of the plurality of targets;

   and accumulating initial doses of the beams contributed by each target point in the plurality of target areas to the maximum dose point in the target areas to obtain the total dose of the beams received by the maximum dose point in the target areas.
6. The method of claim 2, wherein the determining the weight adjustment value for the target region based on the dose contribution coefficient of each of the plurality of target regions to each of the other target regions and the total dose that can be received by the maximum dose point in each of the plurality of target regions comprises:

   determining a weight reference value based on the dose contribution coefficient of each of the plurality of targets to each of the other targets;

   Determining a weight candidate value for each of the plurality of targets based on the dose contribution coefficient of the target to each of the other targets and a total dose receivable by a maximum dose point in each of the plurality of targets;

   a weight adjustment value for the target volume is determined based on the weight reference value and a weight candidate value for the target volume.
7. The method of claim 6, wherein the weight reference value D satisfies:

   wherein Fij is a dose contribution coefficient of each target point in the ith target area to the jth target area, i, j and n are positive integers, i and j are smaller than or equal to n, and n is the total number of the target areas.
8. The method of claim 7, wherein the weight candidate value Di for the ith target volume satisfies:

   wherein dppi is the total dose of the beam that can be received by the i-th maximum dose point in the target region.
9. The method of claim 6, wherein the determining a weight adjustment value for the target zone based on the weight reference value and a weight alternative value for the target zone comprises:

   and determining the ratio of the weight alternative value of the target area to the weight reference value as a weight adjustment value of the target area.
10. The method of any one of claims 1 to 8, wherein said determining an initial weight for each of a plurality of targets comprises:

    for each of the target volumes, determining an initial weight for each of the targets in the target volume using a gradient algorithm or a neural network algorithm such that a total dose of the beam impinging on the target volume is greater than or equal to a dose threshold.
11. A target point weight determining apparatus, the apparatus comprising:

    a first determining module, configured to determine an initial weight of each target point in a plurality of target points, where the plurality of target points are located in a same target area or in a plurality of different target areas;

    a second determining module for determining a target dose of the beam to be received for each of the targets;

    a third determining module for determining, for each of the target volumes, a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of target points, the weight adjustment value being a sum of dose values contributed by the respective one of the target volumes to a maximum dose point in the target volume;

    and the adjusting module is used for adjusting the initial weight of each target point in the target area according to a target proportion based on the weight adjustment value of the target area to obtain the target weight of each target point in the target area, wherein the target weight is used for indicating the irradiation duration of irradiating the target point by using a beam.
12. A host, the host comprising: a processor and a memory having instructions stored therein, the instructions being loaded and executed by the processor to implement the method of weight determination of a target point according to any of claims 1 to 10.
13. A storage medium having instructions stored therein which, when executed on a processing component, cause the processing component to perform the method of weight determination of a target point according to any one of claims 1 to 10.
14. A radiation therapy system, the radiation therapy system comprising: the device comprises a patient support device and a host, wherein the host is connected with the patient support device and is used for adjusting the position of the patient support device;

    wherein the host comprises the apparatus of claim 11 or the host is the host of claim 12.