CN116457060A - Target weight determination method, device and radiotherapy system - Google Patents
Target weight determination method, device and radiotherapy system Download PDFInfo
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- 230000001678 irradiating effect Effects 0.000 claims description 7
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Abstract
A target weight determining method, a target weight determining device and a radiotherapy system belong to the technical field of radiotherapy. Because for each target area, the weight determining device of the target point can determine the corresponding weight adjustment value based on the target dosage of the beam required to be received by each target point in the target areas, and automatically adjust the initial weight of each target point in the target area based on the weight adjustment value to determine the target weight of each target point, the efficiency of determining the target point weight is higher, and the reliability is better.
Description
The disclosure relates to the technical field of radiotherapy, and in particular relates to a target weight determining method, a target weight determining device and a radiotherapy system.
Radiation therapy is an effective means of treating tumors with radiation beams, and treatment planning is one of the essential steps in the overall radiation therapy process. In planning a treatment, a target region is typically set based on the location of the tumor, and a plurality of targets are set within the target region. Accordingly, to ensure the safety and reliability of subsequent radiation treatment, for each target, the treatment plan needs to include: the weight of the target relative to other targets affects the duration of irradiation of the target by the beam.
In the related art, the weight of each target point is flexibly adjusted and set by a therapist according to the total dose of the beam required by treatment and the position and the size of each target point.
However, the weight setting method of the related art is not only inefficient but also less reliable.
Disclosure of Invention
The disclosure provides a target weight determining method, a target weight determining device and a radiotherapy system, which can solve the problems of low efficiency and poor reliability of a weight setting method in the related art. The technical scheme is as follows:
in one aspect, a method for determining a weight of a target is provided, the method comprising:
determining an initial weight for each of a plurality of targets, wherein the plurality of targets are located at the same target area or at a plurality of different target areas;
determining a target dose of the beam to be received for each of the targets;
for each of the target volumes, determining a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of targets in the target volume, the weight adjustment value being a sum of dose values contributed by the respective one of the target volumes to a maximum dose point in the target volume;
And for each target area, adjusting the initial weight of each target point in the target area according to a target proportion based on the weight adjustment value of the target area to obtain the target weight of each target point in the target area, wherein the target weight is used for indicating the irradiation duration of irradiating the target point by using a beam.
Optionally, the plurality of targets are located at a plurality of different target areas; the determining, for each of the target volumes, a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of targets, comprising:
determining a dose contribution factor of all of the targets in the target region to each other target region based on a target dose of the beam required to be received by each of the targets in the target region;
determining a total dose of the beam receivable by a maximum dose point in the target region based on a target dose of the beam required to be received by each of the plurality of targets;
a weight adjustment value for each of the plurality of targets is determined based on the dose contribution coefficient of the target to each of the other targets and a total dose that can be received by a maximum dose point in each of the plurality of targets.
Optionally, the determining a dose contribution coefficient of all the targets in the target region to each other target region based on the target dose of the beam required to be received by each of the targets in the target region includes:
determining a dose contribution value of the target region to each other target region based on a target dose of the beam required to be received by each of the target points in the target region, the dose contribution value being a sum of dose values contributed by respective ones of the target regions to a maximum dose point in each other target region;
for each of the other target volumes, determining a dose contribution coefficient of all of the targets in the target volume to the other target volumes based on the weight adjustment value of the target volume and the dose contribution value of the target volume to the other target volumes.
Optionally, the determining the dose contribution coefficients of all the targets in the target region to the other target region based on the weight adjustment value of the target region and the dose contribution value of the target region to the other target region includes:
and determining the ratio of the weight adjustment value of the target area to the dose contribution value of the target area to the other target areas as the dose contribution coefficient of all targets in the target area to the other target areas.
Optionally, the determining the total dose of the beam that can be received by the maximum dose point in the target region based on the target dose of the beam that is required to be received by each of the targets in the target region includes:
determining an initial dose of the beam contributed by each of the plurality of targets to a point of maximum dose in the target region based on a target dose of the beam required to be received by each of the targets in the plurality of targets;
for each target region, summing the initial dose of the beam contributed by each target point in the plurality of target regions to the maximum dose point in the target region to obtain the total dose of the beam received by the maximum dose point in the target region.
Optionally, the determining the weight adjustment value of the target region based on the dose contribution coefficient of each of the target regions to each of the other target regions and the total dose that can be received by the maximum dose point in each of the target regions includes:
determining a weight reference value based on the dose contribution coefficient of each of the plurality of targets to each of the other targets;
Determining a weight candidate value for each of the plurality of targets based on the dose contribution coefficient of the target to each of the other targets and a total dose receivable by a maximum dose point in each of the plurality of targets;
a weight adjustment value for the target volume is determined based on the weight reference value and a weight candidate value for the target volume.
Optionally, the weight reference value D satisfies:
wherein Fij is a dose contribution coefficient of each target point in the ith target area to the jth target area, i, j and n are positive integers, i and j are smaller than or equal to n, and n is the total number of the target areas.
Optionally, the weight candidate value Di of the ith target area satisfies:
wherein dppi is the total dose of the beam that can be received by the i-th maximum dose point in the target region.
Optionally, the determining a weight adjustment value of the target region based on the weight reference value and a weight alternative value of the target region includes: and determining the ratio of the weight alternative value of the target area to the weight reference value as a weight adjustment value of the target area.
Optionally, the determining the initial weight of each of the targets in the plurality of targets determines the initial weight of each of the targets in the plurality of targets, including:
For each of the target volumes, determining an initial weight for each of the targets in the target volume using a gradient algorithm or a neural network algorithm such that a total dose of the beam impinging on the target volume is greater than or equal to a dose threshold.
In another aspect, a device for determining a weight of a target is provided, the device comprising:
a first determining module, configured to determine an initial weight of each target point in a plurality of target points, where the plurality of target points are located in a same target area or in a plurality of different target areas;
a second determining module for determining a target dose of the beam to be received for each of the targets;
a third determining module for determining, for each of the target volumes, a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of target points, the weight adjustment value being a sum of dose values contributed by the respective one of the target volumes to a maximum dose point in the target volume;
and the adjusting module is used for adjusting the initial weight of each target point in the target area according to a target proportion based on the weight adjustment value of the target area to obtain the target weight of each target point in the target area, wherein the target weight is used for indicating the irradiation duration of irradiating the target point by using a beam.
In yet another aspect, a host is provided, the host comprising: a processor and a memory having instructions stored therein, the instructions being loaded and executed by the processor to implement a method of weight determination of a target as described in the above aspects.
In yet another aspect, a storage medium having instructions stored therein that, when executed on a processing component, cause the processing component to perform a method of weight determination of a target point as described in the above aspects is provided.
In yet another aspect, there is provided a radiation therapy system comprising: the device comprises a patient support device and a host, wherein the host is connected with the patient support device and is used for adjusting the position of the patient support device;
wherein the host comprises the apparatus as described in the above aspect, or the host is the host as described in the above aspect.
The technical scheme provided by the embodiment of the disclosure has at least the following beneficial effects:
the embodiment of the disclosure provides a target weight determining method, a target weight determining device and a radiation therapy system. Because for each target area, the weight determining device of the target point can determine the corresponding weight adjustment value based on the target dosage of the beam required to be received by each target point in the target areas, and automatically adjust the initial weight of each target point in the target area based on the weight adjustment value to determine the target weight of each target point, the efficiency of determining the target point weight is higher, and the reliability is better.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure.
In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings required for the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present disclosure, and other drawings may be obtained according to these drawings without inventive effort for a person of ordinary skill in the art.
FIG. 1 is a schematic diagram of a radiation therapy system provided in an embodiment of the present disclosure;
FIG. 2 is a flowchart of a method for determining weights of targets according to an embodiment of the present disclosure;
FIG. 3 is a flowchart of another method for determining the weight of a target provided by an embodiment of the present disclosure;
FIG. 4 is a flow chart of a method for determining a dose contribution factor provided by an embodiment of the present disclosure;
FIG. 5 is a flow chart of a method for determining the total dose of a beam that can be received by a maximum dose point in a target area according to an embodiment of the present disclosure;
FIG. 6 is a flowchart of a method for determining a weight adjustment value for a target area according to an embodiment of the present disclosure;
FIG. 7 is a block diagram of a target determination device provided by an embodiment of the present disclosure;
FIG. 8 is a block diagram of a third determination module provided by an embodiment of the present disclosure;
fig. 9 is an alternative structural schematic diagram of a host provided in an embodiment of the present disclosure.
Specific embodiments of the present disclosure have been shown by way of the above drawings and will be described in more detail below. These drawings and the written description are not intended to limit the scope of the disclosed concepts in any way, but rather to illustrate the disclosed concepts to those skilled in the art by reference to specific embodiments.
For the purposes of making the objects, technical solutions and advantages of the embodiments of the present disclosure more apparent, the embodiments of the present disclosure will be described in further detail below with reference to the accompanying drawings.
Fig. 1 is a schematic structural view of a radiation therapy system provided in an embodiment of the present disclosure. As shown in fig. 1, the system may include: patient support device 01, host 02, and source device 03.
Alternatively, the patient support apparatus 01 may be a treatment couch as shown in fig. 1, but may be other apparatus for supporting a patient, such as a treatment chair. Host 02 may be a computer device or server. The source device 03 may emit a beam to a target object (e.g., a tumor) to effect treatment of the target object. If the system is a gamma knife therapy system, the radiation source of the source device 03 may be cobalt-60. The therapeutic principle of the gamma knife therapy is as follows: the gamma rays generated by cobalt-60 are geometrically focused on a focus (also called a target point), and human tissues in the target point are destroyed once, so that the aim of treating diseases is fulfilled.
The host 02 may be connected to the patient support apparatus 01 and the source apparatus 03 in communication, for example, wired connection as shown in fig. 1, or wireless connection. The host 02 can flexibly control the position of the patient support device 01 and can control the working state of the source device 03. For example, during radiotherapy, the host 02 may first control the patient support device 01 to move into the source device 03 with the patient, and then control the source device 03 to emit a beam, so as to achieve accurate treatment on the patient.
In order to ensure safety and reliability in radiotherapy and obtain a satisfactory therapeutic effect, a treatment plan is first prepared for a patient before radiotherapy, and if a gamma knife treatment is used, the treatment plan may be referred to as a gamma knife treatment plan. Prior to planning a treatment plan, reference images of the target object are typically acquired for planning the treatment. Alternatively, the reference image may be an electronic computed tomography (computed tomography, CT) image, or a nuclear magnetic resonance (magnetic resonance, MR) image. The treating physician can then reliably plan a treatment based on the size, shape, surrounding tissue, etc. of the target object displayed in the CT image or MR image.
In planning a treatment plan, a treating physician typically sets one or more target areas based on the acquired reference images and one or more target points within each target area, and subsequently, in radiation treatment, the beam may be directed to the set target points to achieve reliable treatment of the target object. In addition, the dose of the beam to be received for each target point is typically determined based on the total beam dose required to treat the target object, and the duration of irradiation of the beam to each target point is determined because the duration of irradiation of the beam to a target point affects the dose of the beam received by the target point. To represent the irradiation duration, a parameter such as a weight is generally used as a reference, for example, for each target, the weight of the target relative to other targets may be proportional to the irradiation duration of the target. As such, in the formulation of treatment plans, flexible adjustments are required to set the weight of each target relative to the other targets, i.e., the relative weight of each target.
In the related art, the relative weights of the targets are generally manually adjusted, which is not only time-consuming and labor-consuming, but also has low efficiency, and because each target has dose contribution to each target, adjusting the weight of a target in one target may affect the dose of beams that can be received by other targets, thus affecting the weight of the target in other targets, and in turn affecting the weight of the target, and repeating the steps. The embodiment of the disclosure provides a method for automatically determining the weight of a target point, which can solve the technical problems of the weight setting method in the related art, and correspondingly can improve the efficiency and quality of treatment planning.
Fig. 2 is a flowchart of a target weight determining method according to an embodiment of the present disclosure, which may be applied to the host 02 shown in fig. 1. As shown in fig. 2, the method may include:
step 201, determining an initial weight of each target point in the plurality of target points.
Wherein the multiple targets may be located at the same target area or may be located at multiple different target areas.
Alternatively, the host may first determine an initial weight for each target, which may refer to an initial relative weight for the target with respect to other targets in the plurality of targets.
Step 202, determining a target dose of the beam to be received for each target spot.
After determining the initial weight for each target point, the host computer can reliably determine the target dose of the beam required to be received by each target point based on the total dose of the beams required to be received by the plurality of target points through dose calculation.
Step 203, for each target region, determining a weight adjustment value for the target region based on the target dose of the beam required to be received by each target point of the plurality of target points.
The weight adjustment value may be a sum of dose values contributed by each target point in the target region to a maximum dose point in the target region.
Optionally, for each target area, after determining the target dose required to be received by each target point in each target area, the host computer may further calculate, based on the determined target dose, a weight adjustment value corresponding to the target area, where the weight adjustment value may be used as a reference for determining the weight of the target point.
And 204, for each target area, adjusting the initial weight of each target point in the target area according to the target proportion based on the weight adjustment value of the target area, and obtaining the target weight of each target point in the target area.
Wherein the target weight may be used to indicate an illumination duration for illuminating the target with the beam. For example, for each target point, the target weight of the target point is proportional to the length of time the beam irradiates the target point. That is, the greater the target weight of a target, the longer the beam irradiates the target, and correspondingly, the greater the dose of the beam that the target can receive. Conversely, the smaller the target weight of a target, the shorter the duration of irradiation of the target by the beam, and correspondingly, the smaller the dose of the beam that the target can receive. Moreover, the target weight for each target may also refer to the target weight for that target relative to other targets in the plurality of targets.
Optionally, for each target area, after determining the weight adjustment value of the target area, the host computer may adjust the initial weight of each target point in the target area according to the target proportion, so as to obtain the target weight of each target point in the target area.
In summary, the embodiments of the present disclosure provide a method for determining a weight of a target. Because for each target area, the corresponding weight adjustment value can be determined based on the target dose of the beam required to be received by each target point in the plurality of target points, and the initial weight of each target point in the target area can be automatically adjusted based on the weight adjustment value to determine the target weight of each target point, the efficiency of determining the target point weight is higher, and the reliability is better.
Fig. 3 is a flowchart of a target weight determining method according to an embodiment of the present disclosure, which may be applied to the host 02 shown in fig. 1. As shown in fig. 3, the method may include:
step 301, determining an initial weight of each target point in the plurality of target points.
Wherein, for each target point, the initial weight of the target point may refer to the relative initial weight of the target point with respect to other target points. It can thus also be determined that there is no concept of weight for a scenario where the entire treatment plan includes only one target.
In planning a treatment plan, a treating physician may first set one or more target volumes based on acquired reference images (e.g., CT images or MR images) of the patient, and then may proceed with the rational placement (also referred to as placement) of one or more targets within each target volume by the treating physician or by a device dedicated to setting targets. That is, the above multiple targets may refer to multiple targets located at the same target area, or may refer to multiple targets located at different target areas. The following examples are presented by way of example only in which the plurality of targets are located at different target areas.
For each target area, starting from the m-th target point placed in the target area, each time a target point is placed, the host can perform weight adjustment on all targets (including the m-th target point and all targets placed before the m-th target point) which are already placed in the target area, and after all targets are placed in the target area, the initial weight of each target point can be determined. Wherein m may be an integer greater than 1.
Alternatively, for each target region, the host computer may employ an optimization algorithm, such as a gradient algorithm or a neural network algorithm, to determine the initial weight of each target point in the target region such that the total dose of the beam impinging the target region is greater than or equal to the dose threshold. That is, for each target region, from the placement of the mth target point, each target point is placed, the host computer may aim at the target region being surrounded by the prescribed metering line by a range greater than the range threshold, i.e., to maximize the range of the irradiation dose received by the target region, and automatically adjust to determine the initial weight of each target point placed using the optimization algorithm described above.
Where the target region is a three-dimensional region, the range of the target region surrounded by the prescribed dose line may refer to the volume of the target region surrounded by the prescribed dose line. If the target area is a two-dimensional planar area, the extent to which the target area is surrounded by the prescribed dose line may refer to the area of the target area surrounded by the prescribed dose line.
Step 302, determining a target dose of the beam to be received for each target spot.
In the embodiment of the disclosure, after determining the initial weight of each target point in the plurality of target points, the host may further complete dose calculation for each target point.
Alternatively, the total dose of the beam required for treatment may be stored in the host, and after determining the initial weight of each target point, the host may calculate the target dose of the beam required to be received by each target point based on the total dose and the initial weight of each target point.
Step 303, for each target region, determining a dose contribution coefficient of all targets in the target region to each other target region based on the target dose of the beam received by each target point in the target region.
Since each target spot contributes to the dose of the beam ultimately received by the respective target spot, after determining the target dose of the beam that each target spot is required to receive, the host computer may first further calculate a dose contribution coefficient for determining the respective target spot in each target spot, i.e., for all target spots to each other target spot, i.e., for each target spot to each other target spot.
For example, if three targets are included, for a first target, determining the dose contribution coefficient of all targets in that target to each other target may refer to: determining a dose contribution factor of each target in the target to the second target, and determining a dose contribution factor of each target in the target to the third target.
By way of example, fig. 4 is a flow chart of a method of determining a dose contribution factor provided by an embodiment of the present disclosure. As shown in fig. 4, the method may include:
step 3031, for each target region, determining a dose contribution value of the target region to each other target region based on the target dose of the beam that each target point in the target region is required to receive.
Wherein for each target region, the target region generally comprises a plurality of other points (which may be represented by pixel points) in addition to the target point, and there is a point of maximum dose of the finally received beam, i.e. a maximum dose point. The dose contribution value of the target to each other target may refer to the sum of the dose values contributed by the individual targets in the target to the point of maximum dose in each other target.
Alternatively, for each target region, the host computer may first determine the dose value contributed by each target point in that target region to the point of maximum dose in the other target region based on the target dose of the beam that each target point in that target region is required to receive. The host computer may then accumulate the dose value contributed by each target in the target to the point of maximum dose in another target, thereby obtaining a dose contribution value of the target to the other target.
Step 3032, for each other target region, determining a dose contribution coefficient of all targets in the target region to the other target region based on the weight adjustment value of the target region and the dose contribution value of the target region to the other target region.
Alternatively, for one target and another other target, the host computer may determine the ratio of the weight adjustment value for the one target and the dose contribution value for the one target to the other target as the dose contribution coefficient for each target in the one target to the other target.
The weight adjustment value of each target region may refer to the sum of dose values contributed by each target point in the target region to the maximum dose point in the target region. That is, for one target and another target, the host computer may use the sum of the dose values contributed by each target in the one target to its own maximum dose point divided by the sum of the dose values contributed to the maximum dose point in the other target to obtain the dose contribution coefficient of the one target to the other target.
Step 304, for each target region, determining a total dose of the beam that can be received by a maximum dose point in the target region based on the target dose of the beam that is required to be received by each target point in the plurality of target points.
Wherein for each target region, the total dose of the beam that can be received by the maximum dose point in that target region may be referred to as: in a plurality of targets set up in a plurality of target areas, each target area contributes to the sum of the dose values of the maximum dose points in the target area. Accordingly, the method shown in fig. 5 may be used to determine the total dose of the beam that can be received at the maximum dose point in each target region. As shown in fig. 5, the method may include:
step 3041, for each target region, determining an initial dose of the beam contributed by each target point of the plurality of target regions to a point of maximum dose in the target region based on a target dose of the beam required to be received by each target point of the plurality of target points.
Alternatively, in embodiments of the present disclosure, for each target region, the host may first determine the initial dose of the beam that each target point contributes to the maximum dose point in that target region based on the target dose of the beam that each target point needs to receive for all targets set.
Step 3042, for each target region, accumulating initial doses of the beams contributed by each target point in the plurality of target regions to the maximum dose point in the target region, to obtain total doses of the beams received by the maximum dose point in the target region.
The host computer may then accumulate the initial dose of the beam contributed by each target spot to the maximum dose point in the target area, thereby obtaining the total dose of the beam that can be received by the maximum dose point in the target area.
Step 305, for each target region, determining a weight adjustment value for the target region based on a dose contribution coefficient of each target region of the plurality of target regions to each other target region, and a total dose that can be received by a maximum dose point of each target region of the plurality of target regions.
For each target, the dose contribution coefficient of that target to the other targets may be referred to as: the dose contribution coefficients of all targets in the target to other targets. After determining the dose contribution coefficient of each target region to each other target region and the total dose that can be received by the maximum dose point in each target region, the host computer may further calculate a weight adjustment value of the target region based on the determined parameters. The weight adjustment value may be a sum of dose values contributed by each target point in the target region to a maximum dose point in the target region.
Optionally, the dose contribution coefficient of each target in each target to each other target, the total dose that can be received by the maximum dose point in each target, and the weight adjustment value of each target may satisfy the following formula:
Wherein Fij is a dose contribution coefficient of each target point in the ith target area to the jth target area, i, j and n are positive integers, i and j are smaller than or equal to n, and n is the total number of the plurality of target areas. For example, F12 refers to the dose contribution coefficient of each target in target 1 to target 2, and the other is the same. The dppi is the total dose of the beam that can be received by the maximum dose point in the ith target region, i.e., the dose of the beam received by the maximum dose point that the ith target region contains contributions from all of the multiple targets. For example, dp1 refers to the total dose of the beam that can be received by the maximum dose point in target 1, and the same applies. Dmaxi is the weight adjustment value of the ith target volume, i.e. the sum of the dose values of the beams contributed by each target point in the ith target volume to the point of maximum dose in the ith target volume. For example, dmax1 refers to the weight adjustment value of the 1 st target region, and the same applies.
Based on the above formula (1), it can be determined that the host computer can determine the weight adjustment value of each target region by the weight adjustment value determination method shown in fig. 6. As shown in fig. 6, the method may include:
step 3051, determining a weight reference value based on the dose contribution coefficient of each target region of the plurality of target regions to each other target region.
Alternatively, it may be determined in conjunction with the above formula (1), and the weight reference value D may satisfy:
that is, in the embodiment of the present disclosure, the host computer may substitute the determined dose contribution coefficient of each target region to each other target region into the above formula (2), and calculate the weight reference value D.
For example, assuming n is 5, i.e. includes a total of 5 target regions, the weight reference value D may satisfy:
step 3052, for each target region, determining a weight candidate value for the target region based on the dose contribution coefficients of each target region of the plurality of target regions to each other target region, and the total dose that can be received by the maximum dose point of each target region of the plurality of target regions.
Alternatively, it may be determined by combining the above formula (1) and formula (2), and the weight candidate value Di of the ith target area may satisfy:
that is, in the embodiment of the present disclosure, the host computer may calculate the weight candidate value Di of the ith target region based on the dose contribution coefficient Fij of each target region of the plurality of target regions to each other target region, and the total dose Dpi of the beam that can be received by the maximum dose point in each target region of the plurality of target regions substituting into the above formula (3).
For example, assuming n is 5, i.e., 5 targets are included in total, the first target weight candidate value D1 to the reference value D5 of the fifth target may satisfy the following formula:
Step 3053, for each target region, determining a weight adjustment value for the target region based on the weight reference value and the weight candidate value for the target region.
Alternatively, for each target, the host computer may determine the ratio of the target's weight candidate value to the weight reference value as the target's weight adjustment value.
For example, assuming that a total of 5 target regions are included, the weight adjustment value Dmax1 of the target region may satisfy for the first target region: dmax1=d1/D. For a second target region, the weight adjustment value Dmax2 of the target region may satisfy: dmax2=d2/D. For the third target region, the weight adjustment value Dmax3 of the target region may satisfy: dmax3=d3/D. For the fourth target region, the weight adjustment value Dmax4 of the target region may satisfy: dmax4=d4/D. For the fifth target region, the weight adjustment value Dmax5 of the target region may satisfy: dmax5=d5/D. D1 to D5 and D can be calculated based on the above corresponding formulas.
Step 306, for each target area, adjusting the initial weight of each target point in the target area according to the target proportion based on the weight adjustment value of the target area, so as to obtain the target weight of each target point in the target area.
Wherein the target weight for each target spot may be used to indicate the duration of irradiation of the target spot with the beam. As for each target point, the target weight of the target point is proportional to the irradiation duration of the beam irradiating the target point. That is, the greater the target weight of a target, the longer the beam irradiates the target, and correspondingly, the greater the dose of the beam that the target can receive. Conversely, the smaller the target weight of a target, the shorter the duration of irradiation of the target by the beam, and correspondingly, the smaller the dose of the beam that the target can receive. Moreover, the target weight for each target may also refer to the target weight for that target relative to other targets in the plurality of targets.
Optionally, in the embodiment of the present disclosure, after determining the weight adjustment value of each target area, the host computer may further adjust the initial weight of each target point in the target area determined in step 301 according to the target scale (i.e., the unified scale) based on the weight adjustment value, to obtain the target weight of each target point in the target area. The target proportion may be input into the host computer in real time by the treating physician, or may be a proportion parameter stored in the host computer in advance.
For example, for each target, the host may scale up or down the initial weight of each target in the target in a uniform ratio such that the sum of the dose values contributed by the adjusted targets to the point of maximum dose in the target reaches the weight adjustment value for the target. That is, for each target region, the irradiation time length of irradiating each target point is controlled based on the finally adjusted target weight of each target point of the target region, so that the sum of the dose values contributed by the respective target points to the maximum dose point in the target region can reach the weight adjustment value of the target region.
It should be noted that, the sequence of the steps of the method for determining the weight of the target point provided in the embodiment of the present disclosure may be appropriately adjusted, for example, step 304 may be performed before step 303, and any method that is easily conceivable to be changed by a person skilled in the art within the technical scope of the present disclosure should be covered in the protection scope of the present disclosure, so that no further description is given.
In summary, the embodiments of the present disclosure provide a method for determining a weight of a target. Because for each target area, the corresponding weight adjustment value can be determined based on the target dose of the beam required to be received by each target point in the plurality of target points, and the initial weight of each target point in the target area can be automatically adjusted based on the weight adjustment value to determine the target weight of each target point, the efficiency of determining the target point weight is higher, and the reliability is better.
Fig. 7 is a block diagram of a target weight determination device provided in an embodiment of the present disclosure. The apparatus can be applied to the host 02 shown in fig. 1. As shown in fig. 7, the apparatus may include:
a first determining module 701 is configured to determine an initial weight of each target point of the plurality of target points.
Wherein the multiple targets may be located at the same target area or at multiple different target areas.
A second determination module 702 is configured to determine a target dose of the beam to be received for each target spot.
A third determining module 703 is configured to determine, for each target region, a weight adjustment value for the target region based on the target dose of the beam that each target point of the plurality of target points needs to receive.
Wherein for each target region, the weight adjustment value of the target region may be the sum of the dose values contributed by the individual targets in the target region to the maximum dose point in the target region.
And the adjusting module 704 is configured to adjust, for each target area, the initial weight of each target point in the target area according to the target proportion based on the weight adjustment value of the target area, so as to obtain the target weight of each target point in the target area.
Wherein, for each target point, the target weight of the target point is used to indicate the irradiation duration for irradiating the target point with the beam.
Alternatively, if multiple targets are located at multiple different target areas. Then, as shown in fig. 8, the third determining module 703 may include:
a first determination submodule 7031 is configured to determine a dose contribution coefficient of all targets in the target region to each other target region based on the target dose of the beam required to be received by each target point in the target region.
A second determination submodule 7032 is configured to determine a total dose of the beam that can be received by a maximum dose point in the target region based on the target dose of the beam that is required to be received by each of the plurality of targets.
A third determining submodule 7033 is configured to determine a weight adjustment value of each target region of the plurality of target regions based on a dose contribution coefficient of the target region to each other target region and a total dose that can be received by a maximum dose point of each target region of the plurality of target regions.
Optionally, the first determining submodule 7031 may be configured to:
For each target region, a dose contribution value of that target region to each of the other target regions is determined based on the target dose of the beam that each target point in the target region is required to receive.
Wherein the dose contribution value may refer to the sum of the dose values contributed by the individual targets in the target region to the maximum dose point in each other target region.
For each other target region, determining a dose contribution coefficient of all targets in the target region to the other target region based on the weight adjustment value of the target region and the dose contribution value of the target region to the other target region.
For example, the first determination submodule 7031 may determine a ratio of the weight adjustment value of the target region and the dose contribution value of the target region to other target regions as a dose contribution coefficient of all targets in the target region to other target regions.
Optionally, the second determining submodule 7032 may be configured to:
for each target region, determining an initial dose of the beam contributed by each target point of the plurality of target regions to a point of maximum dose in the target region based on a target dose of the beam required to be received by each target point of the plurality of target points.
The initial dose of the beam contributed by each target point in the plurality of target areas to the maximum dose point in the target area is accumulated to obtain the total dose of the beam received by the maximum dose point in the target area.
Optionally, a third determination submodule 7033 may be used to:
a weight reference value is determined based on a dose contribution coefficient of each of the plurality of targets to each of the other targets.
For each target region, a weight candidate value for the target region is determined based on a dose contribution coefficient of each target region of the plurality of target regions to each other target region, and a total dose that can be received by a maximum dose point in each target region of the plurality of target regions.
A weight adjustment value for the target volume is determined based on the weight reference value and the weight candidate value for the target volume. For example, for each target region, third determination submodule 7033 may determine a ratio of the weight candidate value of the target region to the weight reference value as the weight adjustment value of the target region.
Alternatively, the weight reference value D may satisfy:
wherein Fij is a dose contribution coefficient of each target point in the ith target area to the jth target area, i, j and n are positive integers, i and j are smaller than or equal to n, and n is the total number of the plurality of target areas.
Alternatively, the weight alternative value Di of the ith target region may satisfy:
wherein, dppi may be the total dose of the beam that can be received by the point of maximum dose in the ith target region.
Optionally, the first determining module 701 may be configured to:
For each target region, an initial weight for each target point in the target region is determined using a gradient algorithm or a neural network algorithm such that the total dose of the beam impinging on the target region is greater than or equal to a dose threshold.
In summary, the embodiment of the disclosure provides a weight determining device for a target. Because for each target area, the device can determine the corresponding weight adjustment value based on the target dose of the beam required to be received by each target point in the multiple target points, and automatically adjust the initial weight of each target point in the target area based on the weight adjustment value to determine the target weight of each target point, the efficiency of determining the target point weight is higher, and the reliability is better.
The specific manner in which the respective modules perform the operations of the target point weight determination device in the above embodiment has been described in detail in the embodiment related to the method, and will not be described in detail here.
Optionally, referring to fig. 9, in an embodiment of the present disclosure, a host computer 02 in the radiation therapy system shown in fig. 1 may include: a processor and a memory. The memory may store instructions that are loaded by the processor and executed to implement a method for determining weights for targets as shown in fig. 2 or 3.
Optionally, embodiments of the present disclosure further provide a storage medium, where instructions may be stored, which when executed on a processing component may cause the processing component to perform a method for determining a weight of a target point as shown in fig. 2 or fig. 3.
The foregoing description of the preferred embodiments of the present disclosure is provided for the purpose of illustration only, and is not intended to limit the disclosure to the particular embodiments disclosed, but on the contrary, the intention is to cover all modifications, equivalents, alternatives, and alternatives falling within the spirit and principles of the embodiments of the present disclosure.
Claims (14)
- A method for determining the weight of a target, the method comprising:determining an initial weight for each of a plurality of targets, wherein the plurality of targets are located at the same target area or at a plurality of different target areas;determining a target dose of the beam to be received for each of the targets;for each of the target volumes, determining a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of target points, the weight adjustment value being a sum of dose values contributed by the respective ones of the target volumes to a maximum dose point in the target volume;And for each target area, adjusting the initial weight of each target point in the target area according to a target proportion based on the weight adjustment value of the target area to obtain the target weight of each target point in the target area, wherein the target weight is used for indicating the irradiation duration of irradiating the target point by using a beam.
- The method of claim 1, wherein the plurality of targets are located at a plurality of different target areas; the determining, for each of the target volumes, a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of targets, comprising:determining a dose contribution factor of all of the targets in the target region to each other target region based on a target dose of the beam required to be received by each of the targets in the target region;determining a total dose of the beam receivable by a maximum dose point in the target region based on a target dose of the beam required to be received by each of the plurality of targets;a weight adjustment value for each of the plurality of targets is determined based on the dose contribution coefficient of the target to each of the other targets and a total dose that can be received by a maximum dose point in each of the plurality of targets.
- The method of claim 2, wherein the determining a dose contribution coefficient of all of the targets in the target region to each other target region based on a target dose of the beam required to be received by each of the targets in the target region comprises:determining a dose contribution value of the target region to each other target region based on a target dose of the beam required to be received by each of the target points in the target region, the dose contribution value being a sum of dose values contributed by respective ones of the target regions to a maximum dose point in each other target region;for each of the other target volumes, determining a dose contribution coefficient of all of the targets in the target volume to the other target volumes based on the weight adjustment value of the target volume and the dose contribution value of the target volume to the other target volumes.
- A method according to claim 3, wherein the determining a dose contribution coefficient of all the targets in the target region to the other target region based on the weight adjustment value of the target region and the dose contribution value of the target region to the other target region comprises:and determining the ratio of the weight adjustment value of the target area to the dose contribution value of the target area to the other target areas as the dose contribution coefficient of the target area to the other target areas.
- The method of claim 2, wherein the determining the total dose of the beam receivable by the maximum dose point in the target region based on the target dose of the beam required to be received by each of the plurality of targets comprises:determining an initial dose of the beam contributed by each of the plurality of targets to a point of maximum dose in the target region based on a target dose of the beam required to be received by each of the plurality of targets;and accumulating initial doses of the beams contributed by each target point in the plurality of target areas to the maximum dose point in the target areas to obtain the total dose of the beams received by the maximum dose point in the target areas.
- The method of claim 2, wherein the determining the weight adjustment value for the target region based on the dose contribution coefficient of each of the plurality of target regions to each of the other target regions and the total dose that can be received by the maximum dose point in each of the plurality of target regions comprises:determining a weight reference value based on the dose contribution coefficient of each of the plurality of targets to each of the other targets;Determining a weight candidate value for each of the plurality of targets based on the dose contribution coefficient of the target to each of the other targets and a total dose receivable by a maximum dose point in each of the plurality of targets;a weight adjustment value for the target volume is determined based on the weight reference value and a weight candidate value for the target volume.
- The method of claim 6, wherein the weight reference value D satisfies:wherein Fij is a dose contribution coefficient of each target point in the ith target area to the jth target area, i, j and n are positive integers, i and j are smaller than or equal to n, and n is the total number of the target areas.
- The method of claim 7, wherein the weight candidate value Di for the ith target volume satisfies:wherein dppi is the total dose of the beam that can be received by the i-th maximum dose point in the target region.
- The method of claim 6, wherein the determining a weight adjustment value for the target zone based on the weight reference value and a weight alternative value for the target zone comprises:and determining the ratio of the weight alternative value of the target area to the weight reference value as a weight adjustment value of the target area.
- The method of any one of claims 1 to 8, wherein said determining an initial weight for each of a plurality of targets comprises:for each of the target volumes, determining an initial weight for each of the targets in the target volume using a gradient algorithm or a neural network algorithm such that a total dose of the beam impinging on the target volume is greater than or equal to a dose threshold.
- A target point weight determining apparatus, the apparatus comprising:a first determining module, configured to determine an initial weight of each target point in a plurality of target points, where the plurality of target points are located in a same target area or in a plurality of different target areas;a second determining module for determining a target dose of the beam to be received for each of the targets;a third determining module for determining, for each of the target volumes, a weight adjustment value for the target volume based on a target dose of the beam required to be received by each of the plurality of target points, the weight adjustment value being a sum of dose values contributed by the respective one of the target volumes to a maximum dose point in the target volume;and the adjusting module is used for adjusting the initial weight of each target point in the target area according to a target proportion based on the weight adjustment value of the target area to obtain the target weight of each target point in the target area, wherein the target weight is used for indicating the irradiation duration of irradiating the target point by using a beam.
- A host, the host comprising: a processor and a memory having instructions stored therein, the instructions being loaded and executed by the processor to implement the method of weight determination of a target point according to any of claims 1 to 10.
- A storage medium having instructions stored therein which, when executed on a processing component, cause the processing component to perform the method of weight determination of a target point according to any one of claims 1 to 10.
- A radiation therapy system, the radiation therapy system comprising: the device comprises a patient support device and a host, wherein the host is connected with the patient support device and is used for adjusting the position of the patient support device;wherein the host comprises the apparatus of claim 11 or the host is the host of claim 12.
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