CN116444413A - Method for synthesizing 2, 3-disubstituted pyrrole compound by utilizing micro-channel reaction device - Google Patents

Method for synthesizing 2, 3-disubstituted pyrrole compound by utilizing micro-channel reaction device Download PDF

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CN116444413A
CN116444413A CN202310420264.1A CN202310420264A CN116444413A CN 116444413 A CN116444413 A CN 116444413A CN 202310420264 A CN202310420264 A CN 202310420264A CN 116444413 A CN116444413 A CN 116444413A
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郭凯
徐高晨
段金电
方正
朱宁
沈磊
李玉光
季栋
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Nanjing Tech University
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

The invention discloses a method for synthesizing 2, 3-disubstituted pyrrole compounds by utilizing a microchannel reaction device, which comprises the following steps: (1) Dissolving alpha, beta-unsaturated ketoxime ester shown in a formula I in a solvent to obtain a reaction solution A; (2) Dissolving 2-benzalacetidine shown in a formula II and paraformaldehyde shown in a formula III and an alkaline additive in a solvent to obtain a reaction solution B; (3) Pumping the reaction liquid A and the reaction liquid B into a micro-channel reactor taking a copper pipe as a reaction pipeline for reaction; (4) And collecting effluent of the microchannel reactor to obtain the 2, 3-disubstituted pyrrole compound shown in the formula IV. The invention provides a method for continuously preparing 2, 3-disubstituted pyrrole compounds by utilizing a microchannel reaction device, wherein the reaction involved in the method is a homogeneous system, a noble metal catalyst is not required to be added, and the method has good substrate adaptability and great potential in the aspect of later industrial application.

Description

Method for synthesizing 2, 3-disubstituted pyrrole compound by utilizing micro-channel reaction device
Technical Field
The invention belongs to the technical field of synthesis of pyrrole compounds, and particularly relates to a method for synthesizing a 2, 3-disubstituted pyrrole compound by using a microchannel reaction device.
Background
Pyrrole is a common structural unit in many natural products and medicines, and has various biological activities such as antifungal, antiviral, hypolipemic, anticancer, etc. In addition, pyrroles play an important role in the synthesis of agrochemicals, dyes and functional materials. Thus, the synthesis of functionalized pyrroles has been of interest to organic synthesizers and pharmacists. At present, the preparation method of the pyrrole derivative mainly comprises the following steps: (1) One-pot four-component serial cyclization of alpha-ketoaldehyde, aniline, activated alkyne and aromatic nucleophile, to synthesize pentasubstituted pyrrole, see (J.org.chem.2020, 85,10,6697-6708); (2) Oxime and azadiene are used as raw materials, and pyrrole derivatives (org.chem.front.2021, 8, 3776-3782) are synthesized through [3+2] spiro-augmentation and aromatization reactions; (3) Copper/amine co-catalyzed regioselective [3+2] cyclization of α, β -unsaturated acetyl oximes with enals to pyrrole derivatives can be seen in the literature (org. Chem. Front.2018,5, 1698-1701). Although the current preparation method of polysubstituted pyrrole has a plurality of routes, the existing method has the problems of using noble metal catalyst, complex reaction steps, long reaction time, low efficiency and the like, and in addition, the synthesis method of 2, 3-disubstituted pyrrole compounds is rarely reported.
Disclosure of Invention
The invention aims to: the invention aims to solve the technical problems of complex reaction steps, long reaction time, low reaction efficiency and the like in the prior art by providing a method for synthesizing 2, 3-disubstituted pyrrole compounds by utilizing a microchannel reaction device, and the method is simple and efficient in realization of efficient synthesis of 2, 3-disubstituted pyrrole compounds under the condition of not using a noble metal catalyst.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device takes alpha, beta-unsaturated ketoxime ester compounds I, 2-benzanilide II and paraformaldehyde III as reaction raw materials, alkaline additives are added, and the 2, 3-disubstituted pyrrole compounds shown in a formula IV are prepared by using the microchannel reaction device, wherein the reaction formula is as follows:
wherein R is 1 、R 2 Independently selected from unsubstituted or substituted phenyl, thienyl, naphthyl, and ester groups; n has a value of 8-50; the micro-channel reaction device adopts a copper pipe micro-channel reactor.
Preferably, the substituted phenyl is selected from phenyl substituted with halogen, C1 alkyl or C1 alkoxy.
More preferably, the R 1 Phenyl, 4-methoxybenzene, 4-bromobenzene, 3-methoxybenzene, 3-bromobenzene, 2-methoxybenzene, thienyl or naphthyl; the R is 2 4-methoxybenzene, 4-chlorobenzene, thienyl, phenyl or ester groups.
Specifically, the method for synthesizing the 2, 3-disubstituted pyrrole compound by utilizing the microchannel reaction device comprises the following specific steps:
(1) Dissolving an alpha, beta-unsaturated ketoxime ester compound I in an organic solvent to prepare a homogeneous solution A; 2-benzalacetidine II, paraformaldehyde III and alkaline additive are dissolved in organic solvent to prepare homogeneous solution B;
(2) Pumping the homogeneous solution A and the homogeneous solution B obtained in the step (1) into a micro-mixer of a micro-channel reaction device respectively and simultaneously, mixing, and then introducing into a copper pipe micro-channel reactor for reaction; the copper tube micro-channel reactor can replace the catalytic action of the transition metal catalyst in the reaction process.
(3) And collecting effluent liquid of the microchannel reactor to obtain the 2, 3-disubstituted pyrrole compound IV.
In the step (1), the organic solvent is any one or more than two of N, N-dimethylacetamide, N-dimethylformamide, 1, 2-dichloroethane, toluene, dimethyl sulfoxide, acetonitrile, tetrahydrofuran, 1, 4-dioxane and ethyl acetate, preferably N, N-dimethylacetamide.
The alkaline additive is any one or more than two of triethylene diamine, triethylamine, tetramethyl ethylenediamine, 4-dimethylaminopyridine, N-diisopropylethylamine, cesium carbonate, potassium carbonate, sodium bisulfite and potassium phosphate, preferably triethylene diamine; the basic additive catalyzes the reaction.
In the step (1), the concentration of the alpha, beta-unsaturated ketoxime ester compound I in the homogeneous solution A is 0.05-0.2 mmol/mL, preferably 0.15mol/L; the concentration of the 2-benzalacetophenone II in the homogeneous phase solution B is 0.05-0.2 mmol/mL, preferably 0.1mol/L; the concentration of paraformaldehyde III in the homogeneous solution B is 0.1-0.4 mmol/mL, preferably 0.3mol/L; the concentration of the basic additive in the homogeneous solution B is 0.01 to 0.1mmol/mL, preferably 0.06mol/L.
In the step (2), the homogeneous phase solutions A and B in the micromixer are pumped, and the molar ratio of the alpha, beta-unsaturated ketoxime ester compound I, the 2-benzalacetidine II, the paraformaldehyde III and the alkaline additive is (1-2): 1 (1-5): 0.1-1, preferably 1.5:1:3:0.6.
In the step (2), the volume ratio of the homogeneous solution A to the homogeneous solution B is (0.8-2): 1, preferably 1:1. The pump inflow rates of the homogeneous solution A and the homogeneous solution B are respectively 0.1-1.0 mL/min, preferably 0.2mL/min.
In the step (2), the reaction temperature in the copper pipe micro-channel reactor is 110-140 ℃, preferably 130 ℃; the reaction residence time is 4-40 min, preferably 10min;
the pipeline in the micro-channel reactor is an activated copper pipe; the reaction volume of the micro-channel reactor is 2-6 mL, and the inner diameter of a pipeline of the reactor is 0.5-1.5 mm; most preferably, the reaction volume of the microchannel reactor is 4mL, and the inner diameter of the pipeline of the reactor is 1mm.
In the step (3), vacuum concentration is adopted to remove the organic solvent by rotary evaporation, and the temperature of the rotary evaporation is 45 ℃; the separation and purification comprises column chromatography by using a developing agent with a ratio of petroleum ether to ethyl acetate of 10:1.
Further, the 2, 3-disubstituted pyrrole compound prepared by the method is also in the protection scope of the invention.
Microchannel reactor technology has gradually become a research hotspot in the technical field of international fine chemistry. A microchannel reactor is a three-dimensional structural element that can be used for chemical reactions, fabricated with a fixed matrix by means of special micromachining techniques. Microchannel reactors typically contain very small channel dimensions (equivalent diameter less than 500 μm) and channel diversity in which fluids flow, mix, react. Thus, there is a very large specific surface area (surface area/volume) in such microstructured chemical devices. The advantages brought by the method are extremely high mass transfer and heat transfer efficiency, namely, the accurate control of the reaction temperature and the instant mixing of the reaction materials in an accurate proportion can be realized. These are all key to improving yield, selectivity, and product quality. In addition, the process in the micro-flow field reaction system is safer, energy-saving and environment-friendly.
The beneficial effects are that:
(1) The invention takes alpha, beta-unsaturated ketoxime ester compounds as substrates to continuously prepare 2, 3-disubstituted pyrrole compounds for the first time, and the method only needs to add alkaline additives into a reaction system and uses a copper pipe micro-channel reactor.
(2) The system designed by the invention has no solid insoluble matters, can not cause the problem of blockage of a micro-flow field pipeline, and has simple and convenient operation, high safety, fast apparent reaction rate and high product selectivity.
(3) The invention does not need to use a transition metal catalyst with high price, reduces the reaction cost and solves the problem of environmental pollution caused by post-treatment.
Drawings
The foregoing and/or other advantages of the invention will become more apparent from the following detailed description of the invention when taken in conjunction with the accompanying drawings and detailed description.
FIG. 1 is a schematic flow chart of the synthesis of 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device.
FIG. 2 is a nuclear magnetic resonance diagram of the compound of example 1.
FIG. 3 is a nuclear magnetic resonance diagram of the compound of example 2.
FIG. 4 is a nuclear magnetic resonance diagram of the compound of example 3.
FIG. 5 is a nuclear magnetic resonance plot of the compound of example 4.
FIG. 6 is a nuclear magnetic resonance plot of the compound of example 5.
FIG. 7 is a nuclear magnetic resonance image of the compound of example 6.
FIG. 8 is a nuclear magnetic resonance plot of the compound of example 7.
FIG. 9 is a nuclear magnetic resonance plot of the compound of example 8.
FIG. 10 is a nuclear magnetic resonance plot of the compound of example 9.
FIG. 11 is a nuclear magnetic resonance plot of the compound of example 10.
FIG. 12 is a nuclear magnetic resonance image of the compound of example 11.
FIG. 13 is a nuclear magnetic resonance image of the compound of example 12.
Detailed Description
The invention will be better understood from the following examples.
Using the apparatus diagram of fig. 1, the following steps are followed: (1) Respectively adding the homogeneous solution A and the homogeneous solution B which are prepared in proportion into a syringe pump a and a syringe pump B; (2) Injecting the mixture into a micro mixer of a micro-channel reaction device according to a certain proportion through an injection pump, mixing the mixture, and then sending the mixture into a copper pipe micro-channel reactor for reaction; (3) The reaction temperature of the copper pipe micro-channel reactor is controlled by an oil bath; (4) The effluent reaction solution was collected, quenched with water, and separated by column chromatography to obtain the target product and yield (column chromatography using 200-300 mesh silica gel manufactured by Shandong Qingdao Kang Yexin medicinal silica gel desiccant Co., ltd.) unless otherwise specified.
The pipeline in the microchannel reactor is an activated copper pipe, and the activation method is as follows: the tubing was first rinsed with 40mL of dilute sulfuric acid solution. Thereafter, the tubing was rinsed with 20mL of distilled water, and again rinsed with 40mL of trifluoroethanol at a flow rate. Finally, the mixture is purged and dried for 20min under nitrogen atmosphere.
Example 1-1
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 90% yield. The nuclear magnetic pattern is shown in fig. 2: 1 H NMR(400MHz,Chloroform-d)δ7.70–7.68(m,2H),7.42–7.37(m,3H),5.69–5.62(m,3H),4.09(q,J＝7.2Hz,2H),2.75(dd,J＝15.9,2.7Hz,1H),2.50(dd,J＝16.0,7.9Hz,1H),1.18(t,J＝7.2Hz,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.4,168.9,131.5,130.7,129.0,128.1,95.7,80.5,61.1,38.6,14.3ppm；HRMS(ESI-TOF):m/z calcd for C 14 H 16 NO 2 [M+H] + 230.1176,found 230.1186.
comparative example 1
0.3mmol (0.0783 g) (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester, 0.2mmol (0.0478 g) 2-benzoylacetanilide, copper powder 0.04mmol (2.5 mg), 0.6mmol (0.018 g) paraformaldehyde and 0.12mmol (0.0134 g) triethylenediamine were dissolved in 2mL of N, N-dimethylacetamide and reacted in a reaction flask at 130℃for 10 hours. After completion of the reaction, water (10 mL) was added thereto, followed by extraction with ethyl acetate (10 mL. Times.3), and the organic layer was washed with saturated NaCl solution (10 mL) and anhydrous Na was added 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 55%.
Examples 1 to 2
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL dimethyl sulfoxide was recorded as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of dimethyl sulfoxide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a microchannel reactor according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is mixed by a Y-type mixer and then enters a microchannel reactor (the inner diameter of a copper tube of the microreactor is 1mm, the volume of the copper tube is 4 mL) to react for 10min at 130 ℃. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 80%.
Examples 1 to 3
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester in 10mL acetonitrile was recorded as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine were dissolved in 10mL of toluene, and the resulting mixed solution was designated as a solutionAnd B, pumping the solution A and the solution B into a micro-channel reaction device according to the flow volume ratio of 1:1, wherein the flow rates are respectively 0.2mL/min, mixing the solution A and the solution B by a Y-type mixer, and then, introducing the mixed solution into the micro-channel reactor (the inner diameter of a copper pipe of the micro-reactor is 1mm, and the volume of the copper pipe is 4 mL), and reacting for 10min at 130 ℃. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 72%.
Examples 1 to 4
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylacetanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0732 g) of 4-methylaminopyridine were dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution was designated as solution B, then the solution A and the solution B were pumped into a microchannel reactor at a flow volume ratio of 1:1 at a flow rate of 0.2mL/min, respectively, and mixed by a Y-type mixer, and then introduced into a microchannel reactor (the inner diameter of copper tube of the microreactor was 1mm, the volume of copper tube was 4 mL), and reacted at 130℃for 10min. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 82%.
Examples 1 to 5
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0606 g) of triethylamine are dissolved in 10mL of N, N-dimethylacetamide, the resulting mixed solution is designated as solution B, and then the solution A and the solution B are pumped into a micro-channel according to a flow volume ratio of 1:1In the reaction device, the flow rates are respectively 0.2mL/min, the mixture is mixed by a Y-type mixer and then enters a micro-channel reactor (the inner diameter of a copper pipe of the micro-reactor is 1mm, and the volume of the copper pipe is 4 mL), and the reaction is carried out for 10min at 130 ℃. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 78% yield.
Examples 1 to 6
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylacetanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0732 g) of 4-methylaminopyridine were dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution was designated as solution B, then the solution A and the solution B were pumped into a microchannel reactor at a flow volume ratio of 1:1 at a flow rate of 0.4mL/min, respectively, and mixed by a Y-type mixer, and then introduced into a microchannel reactor (the inner diameter of copper tube of the microreactor was 1mm, the volume of copper tube was 4 mL), and reacted at 130℃for 5min. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 80%.
Examples 1 to 7
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0732 g) of 4-methylaminopyridine were dissolved in 10mL of N, N-dimethylacetamide, the resulting mixed solution was designated as solution B, and then the solution A and the solution B were pumped into a microchannel reactor at a flow volume ratio of 1:1 at a flow rate of 0.1mL/min, respectively, and mixed by Y-typeMixing and then entering a micro-channel reactor (the inner diameter of a copper pipe of the micro-reactor is 1mm, and the volume of the copper pipe is 4 mL) to react for 20min at 130 ℃. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 83% yield.
Examples 1 to 8
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.4mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 8 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with yield of 85%.
Examples 1 to 9
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine were dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution was designated as solution B, then the solution A and the solution B were pumped into a microchannel reactor at a flow volume ratio of 1:1 at a flow rate of 0.2mL/min, and mixed by a Y-type mixer and then fed into a microchannel reactor (copper of the microreactor)The inner diameter of the tube was 1.5mm and the volume of the copper tube was 4 mL), and reacted at 130℃for 10 minutes. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 76% yield.
Examples 1 to 10
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 120 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 83% yield.
Examples 1 to 11
1.5mmol (0.3915 g) of (2E, 4E) -4- (acetoxyimino) -4-phenyl-2-butenoic acid ethyl ester 10mL of N, N-dimethylacetamide was added to the mixture, and the obtained mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylene diamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to the flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution enters a micro-channel reactor (the inner diameter of a copper pipe of the micro-reactor is 1mm, the volume of the copper pipe is 4 mL) for reaction at 140 ℃ for 1And 0min. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with yield of 85%.
Example 2
1.5mmol (0.4635 g) of ethyl (2E, 4E) -4- (acetoxyimino) -4- (4-methoxyphenyl) but-2-enoate was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 93% yield. The nuclear magnetic pattern is shown in fig. 3: 1 H NMR(400MHz,Chloroform-d)δ7.71(d,J＝8.9Hz,2H),6.94(d,J＝8.9Hz,2H),5.72–5.64(m,3H),4.16(q,J＝7.1Hz,2H),3.84(s,3H),2.79(dd,J＝15.9,2.6Hz,1H),2.54(dd,J＝15.9,8.1Hz,1H),1.24(s,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.4,168.1,162.0,129.7,123.1,114.3,95.3,80.3,61.0,55.4,38.6,14.1ppm；HRMS(ESI-TOF):m/z calcd for C 15 H 18 NO 3 [M+H] + 260.1281,found 260.1292.
example 3
1.5mmol (0.5085 g) of ethyl (2E, 4E) -4- (acetoxyimino) -4- (4-bromophenyl) but-2-enoate was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as a solutionA, A is as follows; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 80%. The nuclear magnetic pattern is shown in fig. 4: 1 H NMR(400MHz,Chloroform-d)δ7.62(q,J＝8.6Hz,4H),5.75–5.62(m,3H),4.16(q,J＝7.1Hz,2H),2.78(dd,J＝15.9,3.0Hz,1H),2.57(dd,J＝16.0,7.8Hz,1H),1.25(t,J＝7.1Hz,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.2,168.1,132.3,129.5,126.1,95.6,80.5,61.2,38.4,14.2ppm；HRMS(ESI-TOF):m/z calcd for C 14 H 15 BrNO 2 [M+H] + 308.0281,found 308.0288.
example 4
1.5mmol (0.4635 g) of ethyl (2E, 4E) -4- (acetoxyimino) -4- (3-methoxyphenyl) but-2-enoate was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressureShrinking to obtain the crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 80%. The nuclear magnetic pattern is shown in fig. 5: 1 H NMR(400MHz,Chloroform-d)δ7.36(d,J＝15.9Hz,2H),7.24(s,1H),7.04(d,J＝10.4Hz,1H),5.76–5.66(m,3H),4.17(q,J＝7.2Hz,2H),3.86(s,3H),2.83(dd,J＝15.9,2.9Hz,1H),2.57(dd,J＝15.9,8.0Hz,1H),1.25(s,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.4,169.0,160.1,132.0,130.0,120.5,117.9,112.7,95.6,80.7,61.1,55.6,38.6,14.3ppm；HRMS(ESI-TOF):m/z calcd for C 15 H 18 NO 3 [M+H] + 260.1281,found 260.1291.
example 5
1.5mmol (0.5085 g) of ethyl (2E, 4E) -4- (acetoxyimino) -4- (3-bromophenyl) but-2-enoate was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 76% yield. The nuclear magnetic pattern is shown in fig. 6: 1 H NMR(400MHz,Chloroform-d)δ7.94(s,1H),7.66–7.61(m,2H),7.33(t,J＝7.9Hz,1H),5.77–5.61(m,3H),4.16(q,J＝7.2Hz,2H),2.79(dd,J＝15.9,3.2Hz,1H),2.57(dd,J＝15.9,7.9Hz,1H),1.26(d,J＝7.1Hz,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.2,167.8,134.5,132.7,131.0,130.6,126.6,123.3,95.7,80.5,61.3,38.4,14.3ppm；HRMS(ESI-TOF):m/z calcd for C 14 H 15 BrNO 2 [M+H] + 308.0281,found 308.0293.
example 6
1.5mmol (0.4635 g) of ethyl (2E, 4E) -4- (acetoxyimino) -4- (2-methoxyphenyl) but-2-enoate was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 75% yield. The nuclear magnetic pattern is shown in fig. 7: 1 H NMR(400MHz,Chloroform-d)δ7.87(dd,J＝7.7,1.6Hz,1H),7.46–7.39(m,1H),7.02(t,J＝7.3Hz,1H),6.93(d,J＝8.4Hz,1H),5.74–5.89(m,3H),4.09(s,2H),3.85(s,3H),2.70(dd,J＝16.4,3.6Hz,1H),2.44(dd,J＝15.8,7.8Hz,1H),1.22(t,J＝7.2Hz,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.8,169.1,157.7,132.6,130.9,121.3,120.4,111.4,94.4,82.5,60.8,55.5,38.0,14.2ppm；HRMS(ESI-TOF):m/z calcd for C 15 H 18 NO 3 [M+H] + 260.1281,found 260.1291.
example 7
1.5mmol (0.4005 g) of (2E, 4E) -4- (acetoxyimino) -4- (thiophen-2-yl) -2-butenoic acid ethyl ester was dissolved in 10mL of N, N-dimethylacetamide, and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine were dissolved in 10mL of N, N-dimethylacetamide, the resulting mixed solution was designated as solution B, and then the solution A and the solution B were pumped into a microchannel reactor at a flow volume ratio of 1:1Wherein the flow rates are respectively 0.2mL/min, and the mixture is mixed by a Y-type mixer and then enters a micro-channel reactor (the inner diameter of a copper pipe of the micro-reactor is 1mm, and the volume of the copper pipe is 4 mL) to react for 10min at 130 ℃. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with a yield of 80%. Nuclear magnetic patterns are shown in fig. 8: 1 H NMR(400MHz,Chloroform-d)δ7.53(d,J＝5.1Hz,1H),7.35(d,J＝3.6Hz,1H),7.11(dd,J＝5.0,3.8Hz,1H),5.67(d,J＝3.8Hz,2H),5.59–5.55(m,1H),4.18(q,J＝7.1Hz,2H),2.91(dd,J＝16.0,3.1Hz,1H),2.66(dd,J＝16.0,8.4Hz,1H),1.26(t,J＝7.2Hz,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.1,163.1,134.5,130.4,129.7,127.8,95.0,80.7,61.0,38.8,14.1ppm；HRMS(ESI-TOF):m/z calcd for C 14 H 14 NO 2 S[M+H] + 236.0740,found 236.0732.
example 8
1.5mmol (0.4665 g) of ethyl (2E, 4E) -4- (acetoxyimino) -4- (2-naphthyl) but-2-enoate was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with yield of 85%. The nuclear magnetic pattern is shown in fig. 9: 1 H NMR(400MHz,Chloroform-d)δ8.10(s,1H),7.98(d,J＝10.3Hz,1H),7.93–7.86(m,3H),7.59–7.53(m,3H),5.86–5.74(m,3H),4.18(q,J＝7.1,1.2Hz,2H),2.91(dd,J＝16.0,3.0Hz,1H),2.64(dd,J＝16.0,8.4Hz,1H),1.25(t,J＝7.2Hz,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ170.5,168.9,134.7,132.9,129.0,128.9,128.6,128.1,128.0,127.9,127.0,124.6,95.7,80.6,61.2,38.7,14.3ppm；HRMS(ESI-TOF):m/z calcd for C 18 H 18 NO 2 [M+H] + 280.1332,found 280.1342.
example 9
1.5mmol (0.3975 g) (1E, 2E) -1, 3-diphenylprop-2-en-1-one O-acetyloxime was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 84% yield. The nuclear magnetic pattern is shown in fig. 10: 1 H NMR(400MHz,Chloroform-d)δ7.57–7.54(m,2H),7.44–7.43(m,8H),5.51(s,1H),5.42(d,J＝2.5Hz,2H),5.38(s,1H),5.16(s,1H)ppm； 13 C NMR(100MHz,Chloroform-d)δ163.8,138.1,138.0,137.9,129.4,128.6,128.5,128.5,128.3,127.7,121.9,79.8,77.3ppm；HRMS(ESI-TOF):m/z calcd for C 17 H 16 N[M+H] + 234.1277,found 234.1289.
example 10
1.5mmol (0.4425 g) (1E, 2E) -3- (4-methoxyphenyl) -1-phenylpropa-2-en-1-one O-acetyloxime was dissolved in 10mL of N, N-dimethylacetamideThe mixed solution is marked as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 86% yield. Nuclear magnetic patterns are shown in fig. 11: 1 H NMR(400MHz,Chloroform-d)δ7.52(d,J＝8.7Hz,2H),7.40(d,J＝4.3Hz,5H),6.93(d,J＝8.8Hz,2H),5.53(s,1H),5.40(d,J＝2.6Hz,2H),5.36(s,1H),5.14(s,1H),3.84(s,3H)ppm； 13 C NMR(100MHz,Chloroform-d)δ163.2,160.8,138.3,138.2,130.7,130.2,128.7,128.5,127.7,121.7,113.7,80.0,77.4,55.5ppm；HRMS(ESI-TOF):m/z calcd for C 18 H 18 NO[M+H] + 264.1383,found264.1389.
example 11
1.5mmol (0.4485 g) (1E, 2E) -3- (4-chlorophenyl) -1-phenylprop-2-en-1-one O-acetyloxime was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 86% yield. The nuclear magnetic pattern is shown in fig. 12: 1 H NMR(400MHz,Chloroform-d)δ7.55–7.52(m,2H),7.43–7.35(m,7H),5.51(s,1H),5.42(d,J＝1.7Hz,2H),5.35(s,1H),5.12(s,1H)ppm； 13 C NMR(100MHz,Chloroform-d)δ164.2,138.5,138.3,137.1,134.9,130.1,129.6,129.4,129.1,128.9,122.6,80.5,77.2ppm；HRMS(ESI-TOF):m/z calcd for C 17 H 15 ClN[M+H] + 268.0888,found 268.0893.
example 12
1.5mmol (0.4065 g) (1E, 2E) -1-phenyl-3- (thiophen-2-yl) prop-2-en-1-one O-acetyloxime was dissolved in 10mL of N, N-dimethylacetamide and the resulting mixed solution was designated as solution A; 1mmol (0.2390 g) of 2-benzoylanilide, 3mmol (0.090 g) of paraformaldehyde and 0.6mmol (0.0672 g) of triethylenediamine are dissolved in 10mL of N, N-dimethylacetamide, the obtained mixed solution is denoted as solution B, then the solution A and the solution B are pumped into a micro-channel reaction device according to a flow volume ratio of 1:1, the flow rates are respectively 0.2mL/min, and the mixed solution is introduced into a micro-channel reactor (the inner diameter of a copper tube of the micro-reactor is 1mm, the volume of the copper tube is 4 mL) for reaction at 130 ℃ for 10min after being mixed by a Y-type mixer. The microreactor was discharged to obtain an organic phase, to which was added water (40 mL), followed by extraction with ethyl acetate (40 mL. Times.3), and the organic layer was washed with saturated NaCl solution (30 mL) and added anhydrous Na 2 SO 4 Drying and concentrating under reduced pressure to obtain a crude product. Separating by column chromatography with a developer with petroleum ether and ethyl acetate ratio of 10:1 to obtain the target product shown in Table 1, with 78% yield. Nuclear magnetic patterns are shown in fig. 13: 1 H NMR(400MHz,Chloroform-d)δ7.56(dd,J＝6.5,3.1Hz,2H),7.44–7.43(m,3H),7.36(dd,J＝5.0,1.2Hz,1H),7.08(d,J＝3.5Hz,1H),7.03(d,J＝8.6Hz,1H),5.72(s,1H),5.58(s,1H),5.43(d,J＝12.6Hz,2H),5.37(s,1H)ppm； 13 C NMR(100MHz,Chloroform-d)δ163.1,141.3,138.1,136.6,129.6,128.6,128.4,126.9,126.6,126.5,122.0,78.4,73.1ppm；HRMS(ESI-TOF):m/z calcd for C 15 H 14 NS[M+H] + 240.0841,found 240.0832.
TABLE 1 Compounds of the invention
The invention provides a method for synthesizing 2, 3-disubstituted pyrrole compounds by utilizing a microchannel reaction device, and the method and the way for realizing the technical scheme are numerous, the above is only a preferred embodiment of the invention, and it should be pointed out that a plurality of improvements and modifications can be made by those skilled in the art without departing from the principle of the invention, and the improvements and modifications are also considered as the protection scope of the invention. The components not explicitly described in this embodiment can be implemented by using the prior art.

Claims (10)

1. A method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device is characterized in that alpha, beta-unsaturated ketoxime ester compounds I, 2-benzalacetophenone II and paraformaldehyde III are used as reaction raw materials, alkaline additives are added, and the 2, 3-disubstituted pyrrole compounds shown in a formula IV are prepared by using the microchannel reaction device, wherein the reaction formula is as follows:
wherein R is 1 、R 2 Independently selected from unsubstituted or substituted phenyl, thienyl, naphthyl, and ester groups; n has a value of 8-50; the micro-channel reaction device adopts a copper pipe micro-channel reactor.
2. The method for synthesizing 2, 3-disubstituted pyrroles using a microchannel reaction apparatus according to claim 1, wherein the substituted phenyl is selected from phenyl substituted with halogen, C1 alkyl or C1 alkoxy.
3. The method for synthesizing 2, 3-disubstituted pyrrole compounds using a microchannel reactor according to claim 1, wherein R is as follows 1 4-methoxybenzene, 4-bromobenzene, 3-methoxybenzene, 3-bromobenzene, 2-methoxybenzene, thienyl or naphthyl; the R is 2 4-methoxybenzene, 4-chlorobenzene, thienyl, phenyl or ester groups.
4. The method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device according to claim 1, wherein the specific steps are as follows:
(1) Dissolving an alpha, beta-unsaturated ketoxime ester compound I in an organic solvent to prepare a homogeneous solution A; dissolving 2-benzalacetidine II, paraformaldehyde III and alkaline additives in an organic solvent to prepare a homogeneous phase solution B;
(2) Pumping the homogeneous solution A and the homogeneous solution B obtained in the step (1) into a micro-mixer of a micro-channel reaction device respectively and simultaneously, mixing, and then introducing into a copper pipe micro-channel reactor for reaction;
(3) And collecting effluent liquid of the microchannel reactor to obtain the 2, 3-disubstituted pyrrole compound IV.
5. The method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device according to claim 4, wherein in the step (1), the organic solvent is any one or more of N, N-dimethylacetamide, N-dimethylformamide, 1, 2-dichloroethane, toluene, dimethyl sulfoxide, acetonitrile, tetrahydrofuran, 1, 4-dioxane and ethyl acetate; the alkaline additive is any one or more than two of triethylene diamine, triethylamine, tetramethyl ethylenediamine, 4-dimethylaminopyridine, N-diisopropylethylamine, cesium carbonate, potassium carbonate, sodium bisulfate and potassium phosphate.
6. The method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device according to claim 4, wherein in the step (1), the concentration of the alpha, beta-unsaturated ketoxime ester compound I in the homogeneous solution A is 0.05-0.2 mmol/mL; the concentration of the 2-benzalacetophenone II in the homogeneous phase solution B is 0.05-0.2 mmol/mL, the concentration of the paraformaldehyde III in the homogeneous phase solution B is 0.1-0.4 mmol/mL, and the concentration of the alkaline additive in the homogeneous phase solution B is 0.01-0.1 mmol/mL.
7. The method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device according to claim 4, wherein in the step (2), the molar ratio of the alpha, beta-unsaturated ketoxime ester compound I, the 2-benzalacetophenone II, the paraformaldehyde III and the alkaline additive is (1-2): 1 (1-5): 0.1-1, and the alpha, beta-unsaturated ketoxime ester compound I, the 2-benzalacetophenone II, the paraformaldehyde III and the alkaline additive are pumped into homogeneous solutions A and B in a micromixer.
8. The method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reaction device according to claim 4, wherein in the step (2), the volume ratio of the homogeneous solution A to the homogeneous solution B is (0.8-2): 1, and the pump inflow rates of the homogeneous solution A and the homogeneous solution B are respectively 0.1-1.0 mL/min.
9. The method for synthesizing 2, 3-disubstituted pyrrole compounds by using a microchannel reactor according to claim 4, wherein in the step (2), the reaction temperature in the copper tube microchannel reactor is 110-140 ℃ and the reaction residence time is 4-40 min.
10. The 2, 3-disubstituted pyrrole compound prepared by any one of the preparation methods of claims 1 to 9.
CN202310420264.1A 2023-04-19 2023-04-19 Method for synthesizing 2, 3-disubstituted pyrrole compound by utilizing micro-channel reaction device Pending CN116444413A (en)

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