CN116439724A - Forehead electroencephalogram and blood oxygen information measuring device, forehead electroencephalogram and blood oxygen information measuring system and parameter optimizing method - Google Patents
Forehead electroencephalogram and blood oxygen information measuring device, forehead electroencephalogram and blood oxygen information measuring system and parameter optimizing method Download PDFInfo
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- 239000001301 oxygen Substances 0.000 title claims abstract description 174
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 174
- 210000001061 forehead Anatomy 0.000 title claims abstract description 48
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
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- A61B5/377—Electroencephalography [EEG] using evoked responses
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- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
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Abstract
The invention relates to the technical fields of instrument science and technology, near infrared optics and biomedical intersection, in particular to a forehead electroencephalogram and blood oxygen information measuring device, a forehead electroencephalogram and blood oxygen information measuring system and a forehead electroencephalogram and blood oxygen information parameter optimizing method. Wherein, the device includes: the infrared detection module and the moving module are used for controlling the infrared detection module to move; the brain electricity acquisition module is used for acquiring brain electricity signals of the brain of the tested person; the controller is respectively in communication connection with the infrared detection module, the mobile module and the electroencephalogram acquisition module to control the infrared detection module and the mobile module to measure blood oxygen information and control the electroencephalogram acquisition module to measure forehead electroencephalogram; the controller is connected with a preset high-precision oximeter to perform optimization of target parameters; the target parameters include position parameters, intensity parameters, sampling frequency parameters, detection threshold parameters and luminous intensity parameters. The controller is connected with a preset event stimulator to perform optimization of the synchronous time parameters of the electroencephalogram acquisition module based on the event stimulator.
Description
Technical Field
The invention relates to the technical fields of instrument science and technology, near infrared optics and biomedical intersection, in particular to a forehead electroencephalogram and blood oxygen information measuring device, a forehead electroencephalogram and blood oxygen information measuring system and a forehead electroencephalogram and blood oxygen information parameter optimizing method.
Background
The measurement of the hemoglobin concentration and the blood oxygen saturation in blood oxygen information is divided into non-invasive measurement and invasive measurement, wherein the invasive measurement is to collect blood of a measured object, and then to carry out chemical analysis by adopting a blood gas analyzer to obtain the blood oxygen saturation; the noninvasive measurement measures the light transmission intensity through the tissue bed by using infrared light as an incident light source, and can calculate the hemoglobin concentration and the blood oxygen saturation of the measured object in a quiet environment.
The research shows that the accuracy of the near infrared blood oxygen information measuring equipment is influenced by factors such as the contact position and strength of a near infrared emitting diode and a near infrared receiving diode with the brain of a tested person, the thickness of the cerebral cortex of the tested person, the signal sampling frequency, the detection threshold, the emission power of the infrared diode and the like, the existing research only gives out factors influencing the accuracy of blood oxygen measurement, but does not give out how to search the optimized parameters influencing the near infrared blood oxygen information measuring equipment through an automatic means, so that the debugging is complicated in the equipment development process and the efficiency is low. When the environmental temperature of the tested person is greatly changed during the test, the transmitting power of the infrared diode, the receiving signal detection threshold of the infrared diode and the like can be influenced, so that the accuracy of blood oxygen information measurement is influenced.
The brain electrical information of the brain comprises spontaneous brain electrical information and evoked brain electrical information, wherein the spontaneous brain electrical information is brain electrical signals generated by the brain when no external stimulus event exists; the evoked electroencephalogram information refers to that brain generates electroencephalogram signals with corresponding characteristics when aiming at certain stimulation events (such as sound, smell, images, light and the like), the occurrence time of the electroencephalogram signals (defined as the synchronous time of the stimulation events and the electroencephalogram signals) has uncertainty, and is related to the physiological characteristics (such as epilepsy, mental stress and the like) of a tested object, but the starting time of the electroencephalogram signals under the stimulation can be found to be used for accurately judging clinical diseases, on the other hand, by taking blood oxygen information of the brain as an auxiliary means and combining the electroencephalogram information, the physiological change and disease diagnosis of the tested object aiming at the specific stimulation events can be researched, and the electroencephalogram information processing method can be widely applied to the technical field of brain-computer interfaces.
In some cases, forehead electroencephalogram and blood oxygen information of a tested person need to be obtained in real time, but the problems that the optimal system parameters of equipment are inconsistent during measurement of cerebral blood oxygen of different tested persons, the efficiency of manually adjusting the system parameters is low and the synchronization time deviation of different tested persons and electroencephalogram signals is large for specific stimulation events exist.
Disclosure of Invention
In view of the foregoing, embodiments of the present invention are directed to providing a forehead electroencephalogram and blood oxygen information measurement apparatus, system, and parameter optimizing method to solve the above-described problems.
The first aspect of the present invention provides a forehead electroencephalogram and blood oxygen information measurement apparatus, comprising:
the infrared detection module is used for radiating the emitted infrared light to the brain of the tested person and receiving the light intensity signal reflected by the brain;
the moving module is used for fixing the infrared detection module and controlling the infrared detection module to move;
the brain electricity acquisition module is used for acquiring brain electricity signals of the brain of the tested person;
the controller is respectively in communication connection with the infrared detection module, the mobile module and the electroencephalogram acquisition module so as to control the infrared detection module and the mobile module to measure blood oxygen information and control the electroencephalogram acquisition module to measure forehead electroencephalogram;
the controller comprises a first interface, wherein the first interface is used for being connected with a preset high-precision oximeter so as to optimize target parameters based on the high-precision oximeter;
the controller comprises a second interface, and is used for being connected with a preset event stimulator through the second interface so as to carry out optimization of the synchronous time parameters of the electroencephalogram acquisition module based on the event stimulator.
In some embodiments, the infrared detection module comprises: the device comprises a near infrared emitting diode power driving circuit, a functional near infrared emitting diode, a functional near infrared receiving diode and a received signal detection module;
the near infrared emitting diode power driving circuit is respectively connected with the controller and the functional near infrared emitting diode;
the receiving signal detection module is respectively connected with the controller and the functional near infrared receiving diode;
the controller is used for driving the functional near infrared emitting diode to emit light rays to a target area of a tested person through the near infrared emitting diode power driving circuit;
the functional near infrared receiving diode is used for receiving the light reflected by the target area and sending a light intensity signal to the controller through the receiving signal detection module;
the controller is used for determining blood oxygen information based on the light intensity signal and lambert beer law.
In some embodiments, the mobile module comprises: the three-axis stepping motor, the stepping motor position measuring module and the circular motion are converted into a three-dimensional motion device;
the three-axis stepping motor is respectively in communication connection with the stepping motor position measuring module, the device for converting the circular motion into the three-dimensional motion and the controller;
The circular motion is converted into a three-dimensional motion device which is used for fixing the functional near infrared emitting diode and the functional near infrared receiving diode;
the controller is used for converting the circular motion of the three-axis stepping motor into three-dimensional curve motion through the three-axis stepping motor and the circular motion conversion device, and adjusting the contact positions and the force between the functional near infrared emitting diode and the functional near infrared receiving diode and the tested person through the circular motion conversion device;
the stepping motor position measurement module is used for detecting actual movement position quantities of the functional near infrared emitting diode and the functional near infrared receiving diode and feeding back the actual movement position quantities to the controller;
the controller performs closed-loop control on the three-axis stepping motor based on the actual movement position quantity.
In some embodiments, further comprising: a temperature sensor;
the temperature sensor is in communication connection with the controller and is used for acquiring temperature information and sending the acquired temperature information to the controller;
the controller is further configured to determine a temperature compensation coefficient based on the temperature information;
the temperature compensation coefficient is used for performing temperature compensation on blood oxygen information obtained by detection based on the infrared detection module.
A second aspect of the present invention provides a system for measuring information of forehead electroencephalogram and blood oxygen, comprising: high-precision oximeter, event stimulator and forehead electroencephalogram and blood oxygen information measuring device;
the high-precision oximeter is connected with a controller of the forehead electroencephalogram and blood oxygen information measuring device through the first interface; the event stimulator is connected with the controller of the forehead electroencephalogram and blood oxygen information measuring device through the second interface.
The third aspect of the present invention provides a parameter optimizing method, which is applied to the forehead electroencephalogram and blood oxygen information measuring device, and comprises the following steps:
the target parameters of the infrared detection module are controlled to be changed within a preset range; for each target parameter, calculating first difference information between a second blood oxygen detection result and a first blood oxygen detection result according to a first blood oxygen detection result measured by an infrared detection module and a second blood oxygen detection result measured by the high-precision oximeter at the same time; determining a target parameter corresponding to the minimum first difference information as an optimal parameter;
applying standard stimulation events to the brain of a tested person through an event stimulator so as to activate different areas of the brain, and collecting brain electrical signals of the brain of the tested person through an electroencephalogram collection module; based on the time of applying the stimulation event and the brain electrical signals of the brain of the tested person, the synchronous time parameter of the stimulation event and the brain electrical signals is calculated by using a matched filter and a summation algorithm.
In some embodiments, further comprising:
acquiring temperature information acquired by the temperature sensor;
based on the temperature information, a temperature compensation coefficient is determined.
A fourth aspect of the present invention provides a parameter optimizing apparatus applied to the forehead electroencephalogram and blood oxygen information measuring apparatus, including:
the first optimizing module is used for controlling the target parameters of the infrared detection module to change within a preset range; for each target parameter, calculating first difference information between a second blood oxygen detection result and a first blood oxygen detection result according to a first blood oxygen detection result measured by an infrared detection module and a second blood oxygen detection result measured by the high-precision oximeter at the same time; determining a target parameter corresponding to the minimum first difference information as an optimal parameter;
the second optimizing module is used for applying standard stimulation events to the brain of the tested person through the event stimulator so as to activate different areas of the brain, and collecting brain electrical signals of the brain of the tested person through the brain electrical collecting module; based on the time of applying the stimulation event and the brain electrical signals of the brain of the tested person, the synchronous time of the stimulation event and the brain electrical signals is calculated by using a matched filter and a summation algorithm.
A fifth aspect of the present invention provides an electronic device, comprising:
a processor and a memory for storing a program executable by the processor;
the processor is configured to implement the above-mentioned parameter optimizing method by running the program in the memory.
A sixth aspect of the present invention provides a computer readable storage medium having stored thereon a computer program which, when executed by a processor, causes the processor to perform a parameter optimizing method as described above.
The forehead electroencephalogram and blood oxygen information measuring device provided by the invention is respectively connected with a preset high-precision oximeter and an event stimulator, so that the position parameter and the force parameter of the mobile module are optimized based on the high-precision oximeter, and the synchronous time parameter of the electroencephalogram acquisition module is optimized based on the event stimulator. The parameter optimizing is automatically carried out, the problem of low efficiency of manually adjusting the system parameters is avoided, and the problem of large synchronization time deviation of different testees aiming at specific stimulation events and electroencephalogram signals is solved by automatically determining the synchronization time (namely the synchronization time parameters).
Drawings
The above and other objects, features and advantages of the present invention will become more apparent by describing embodiments of the present invention in more detail with reference to the attached drawings. The accompanying drawings are included to provide a further understanding of embodiments of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, and not constitute a limitation to the invention. In the drawings, like reference numerals generally refer to like parts or steps.
Fig. 1 is a schematic structural diagram of a forehead electroencephalogram and blood oxygen information measurement apparatus according to an embodiment of the present invention.
Fig. 2 is a flow chart of a parameter optimizing method according to an embodiment of the present invention.
Fig. 3 is a flow chart of a method for using the forehead electroencephalogram and blood oxygen information measurement apparatus according to one embodiment of the present invention.
Fig. 4 is a schematic flow chart of determining a synchronization time parameter according to an embodiment of the present invention.
Fig. 5 is a schematic structural diagram of an electronic device according to an embodiment of the present invention.
Reference numerals:
1. a temperature sensor; 2. a controller; 3. a near infrared emitting diode power driving circuit; 4. a functional near infrared emitting diode; 5. an electroencephalogram acquisition module; 6. a subject; 7. an event stimulator; 8. a received signal detection module; 9. a functional near infrared receiving diode; 10. a step motor position measuring module; 11. a three-axis stepper motor; 12. the circular motion is converted into a three-dimensional motion device; 13. a high-precision oximeter; 14. an infrared detection module; 15. and a mobile module.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Summary of the application
The measurement of the hemoglobin concentration and the blood oxygen saturation in blood oxygen information is divided into non-invasive measurement and invasive measurement, wherein the invasive measurement is to collect blood of a measured object, and then to carry out chemical analysis by adopting a blood gas analyzer to obtain the blood oxygen saturation; the noninvasive measurement measures the light transmission intensity through the tissue bed by using infrared light as an incident light source, and can calculate the hemoglobin concentration and the blood oxygen saturation of the measured object in a quiet environment.
The research shows that the accuracy of the near infrared blood oxygen information measuring equipment is influenced by factors such as the contact position and strength of a near infrared emitting diode and a near infrared receiving diode with the brain of a tested person, the thickness of the cerebral cortex of the tested person, the signal sampling frequency, the detection threshold, the emission power of the infrared diode and the like, the existing research only gives out factors influencing the accuracy of blood oxygen measurement, but does not give out how to search the optimized parameters influencing the near infrared blood oxygen information measuring equipment through an automatic means, so that the debugging is complicated in the equipment development process and the efficiency is low. When the environmental temperature of the tested person is greatly changed during the test, the transmitting power of the infrared diode, the receiving signal detection threshold of the infrared diode and the like can be influenced, so that the accuracy of blood oxygen information measurement is influenced.
The brain electrical information of the brain comprises spontaneous brain electrical information and evoked brain electrical information, wherein the spontaneous brain electrical information is brain electrical signals generated by the brain when no external stimulus event exists; the evoked electroencephalogram information refers to that brain generates electroencephalogram signals with corresponding characteristics when aiming at certain stimulation events (such as sound, smell, images, light and the like), the occurrence time of the electroencephalogram signals (defined as the synchronous time of the stimulation events and the electroencephalogram signals) has uncertainty, and is related to the physiological characteristics (such as epilepsy, mental stress and the like) of a tested object, but the starting time of the electroencephalogram signals under the stimulation can be found to be used for accurately judging clinical diseases, on the other hand, by taking blood oxygen information of the brain as an auxiliary means and combining the electroencephalogram information, the physiological change and disease diagnosis of the tested object aiming at the specific stimulation events can be researched, and the electroencephalogram information processing method can be widely applied to the technical field of brain-computer interfaces.
The matched filter is widely applied to the technical fields of radars, sonars and the like, and can also be used for signal delay time estimation. The matched filter is a linear filter, the transfer function form of the matched filter is the conjugate of the signal spectrum, and the transmission of useful signals can be realized as far as possible while noise signals are prevented, so that the maximum signal-to-noise ratio of output signals, namely the maximum ratio of the instantaneous power of the signals to the average power of the noise, is realized.
Therefore, the research scheme solves the problem of low efficiency of manually adjusting the system parameters due to inconsistent optimal system parameters of equipment in cerebral blood oxygen measurement of different testees; the method solves the problem that the measurement is inaccurate when the ambient temperature of the testee is greatly changed during the test, and simultaneously solves the problem that the synchronous time deviation of specific stimulation events and the electroencephalogram signals of different testees is large.
In order to solve the above-described problems, the present invention provides a forehead electroencephalogram and blood oxygen information measurement apparatus including: the infrared detection module is used for radiating the emitted infrared light to the brain of the tested person and receiving the light intensity signal reflected by the brain; the moving module is used for fixing the infrared detection module and controlling the infrared detection module to move; the brain electricity acquisition module is used for acquiring brain electricity signals of the brain of the tested person; the controller is respectively in communication connection with the infrared detection module, the mobile module and the electroencephalogram acquisition module so as to control the infrared detection module and the mobile module to measure blood oxygen information and control the electroencephalogram acquisition module to measure forehead electroencephalogram; the controller comprises a first interface, wherein the first interface is used for being connected with a preset high-precision oximeter so as to optimize target parameters based on the high-precision oximeter; the controller comprises a second interface, and is used for being connected with a preset event stimulator through the second interface so as to carry out optimization of the synchronous time parameters of the electroencephalogram acquisition module based on the event stimulator. Therefore, the parameter optimizing is automatically carried out, the problem of low efficiency of manually adjusting the system parameters is avoided, and the problem of large synchronization time deviation of different testees aiming at specific stimulation events and electroencephalogram signals is solved by automatically determining the synchronization time (namely the synchronization time parameters).
Specifically, the main purpose of the invention is as follows:
(1) The brain blood oxygen information of the tested person is measured by using the high-precision oximeter as a reference standard, the system parameters of the measuring device are automatically calibrated, and the problem that the brain blood oxygen measurement optimization parameters of different tested persons are inconsistent and the system parameters (namely the target parameters in the invention) are required to be manually adjusted is solved; measuring brain blood oxygen information of a tested person by using a high-precision oximeter as a reference standard, controlling a stepping motor by using a closed-loop control technology aiming at different tested objects to obtain an optimized position, an optimized contact force and an optimized luminous intensity of a functional near infrared emitting diode and a functional near infrared receiving diode which are in contact with the brain of the tested person, searching for optimized system parameters for measuring the brain blood oxygen information of the tested person, and solving the problem of troublesome manual adjustment of the system parameters;
(2) The temperature calibration and compensation are carried out on the cerebral blood oxygen measurement result by utilizing the data of the temperature sensor, so that the problem that the blood oxygen measurement result is inaccurate when the ambient temperature of a tested person changes greatly during the test is solved;
(3) And the synchronous time of the stimulation event and the electroencephalogram signal under the specific stimulation event is automatically obtained by using a matched filter and an accumulation algorithm, so that the problem that the synchronous time deviation of the stimulation event and the electroencephalogram signal under the specific stimulation event is large for different testees is solved.
Having described the basic principles of the present invention, various non-limiting embodiments of the present invention will now be described in detail with reference to the accompanying drawings.
Exemplary apparatus
Fig. 1 is a schematic structural diagram of a forehead electroencephalogram and blood oxygen information measurement apparatus according to an embodiment of the present invention. As shown in fig. 1, the apparatus includes the following.
An infrared detection module 14 for radiating the emitted infrared light to the brain of the subject 6 and receiving the light intensity signal reflected by the brain;
a moving module 15 for fixing the infrared detection module 14, and controls the infrared detection module 14 to move;
an electroencephalogram acquisition module 5 for acquiring electroencephalogram signals of the brain of the subject 6;
the controller 2 is respectively in communication connection with the infrared detection module 14, the mobile module 15 and the electroencephalogram acquisition module 5, so as to control the infrared detection module 14 and the mobile module 15 to measure blood oxygen information and control the electroencephalogram acquisition module 5 to measure forehead electroencephalogram;
the controller 2 comprises a first interface, and is used for being connected with a preset high-precision oximeter 13 through the first interface so as to perform optimization of target parameters based on the high-precision oximeter 13;
the target parameters comprise position parameters, strength parameters, sampling frequency parameters and detection threshold parameters;
The controller 2 comprises a second interface, and is configured to connect with a preset event stimulator 7 through the second interface, so as to perform optimization of the synchronization time parameter of the electroencephalogram acquisition module 5 based on the event stimulator 7.
Based on the external high-precision oximeter 13 and the event stimulator 7, parameter optimization is automatically performed, the problem of low efficiency of manually adjusting system parameters is avoided, and the problem of large deviation of the synchronization time of different testees 6 for specific stimulation events and electroencephalogram signals is solved by automatically determining the synchronization time (namely the synchronization time parameters).
Specifically, the infrared detection module 14 includes: the power driving circuit 3 of the near infrared emitting diode, the functional near infrared emitting diode 4, the functional near infrared receiving diode 9 and the receiving signal detecting module 8;
the near infrared emitting diode power driving circuit 3 is respectively connected with the controller 2 and the functional near infrared emitting diode 4;
the receiving signal detection module 8 is respectively connected with the controller 2 and the functional near infrared receiving diode 9;
the controller 2 is used for driving the functional near infrared emitting diode 4 to emit light rays to a target area of a tested person through the near infrared emitting diode power driving circuit 3;
The functional near infrared receiving diode 9 is used for receiving the light reflected by the target area and sending a light intensity signal to the controller 2 through the receiving signal detecting module 8;
the controller 2 is configured to determine blood oxygen information based on the light intensity signal and lambert beer's law.
Further, the mobile module 15 includes: the three-axis stepping motor 11, the stepping motor position measuring module 10 and the circular motion are converted into a three-dimensional motion device 12;
the three-axis stepping motor 11 is respectively in communication connection with the stepping motor position measuring module 10, the circular motion converting device 12 and the controller 2;
the circular motion is converted into a three-dimensional motion device 12 for fixing the functional near infrared emitting diode 4 and the functional near infrared receiving diode 9;
the controller 2 is used for converting the circular motion of the three-axis stepping motor 11 into three-dimensional curve motion through the three-axis stepping motor 11 and the circular motion conversion three-dimensional motion device 12, and adjusting the contact positions and the force between the functional near infrared emitting diode 4 and the functional near infrared receiving diode 9 and the tested person 6 through the circular motion conversion three-dimensional motion device 12;
The stepping motor position measuring module 10 is used for detecting actual movement position quantities of the functional near infrared emitting diode 4 and the functional near infrared receiving diode 9 and feeding back the actual movement position quantities to the controller 2;
the controller 2 performs closed-loop control of the three-axis stepping motor 11 based on the actual movement position amount.
The infrared detection module 14 can be controlled through the moving module 15, specifically, the movement of the functional near infrared emitting diode 4 and the functional near infrared receiving diode 9 can be controlled, the position is optimized, the contact force is optimized, the luminous intensity of the functional near infrared emitting diode 4 is optimized, the optimized system parameters for measuring the cerebral blood oxygen information of the tested person 6 are searched, and the problem of trouble in manually adjusting the system parameters is solved;
further, the scheme provided by the invention further comprises the following steps: a temperature sensor 1;
the temperature sensor 1 is in communication connection with the controller 2, and is used for acquiring temperature information and sending the acquired temperature information to the controller 2;
the controller 2 is further configured to determine a temperature compensation coefficient based on the temperature information;
wherein the temperature compensation coefficient is used for performing temperature compensation on blood oxygen information obtained by detection based on the infrared detection module 14.
Thus, the temperature calibration and compensation are carried out on the cerebral blood oxygen measurement result by utilizing the data of the temperature sensor 1, and the problem that the blood oxygen measurement result is inaccurate when the ambient temperature of the tested person 6 is greatly changed in the test is solved.
Exemplary System
Based on the same conception, the invention also provides a forehead electroencephalogram and blood oxygen information measurement system which comprises: the high-precision oximeter, the event stimulator and the forehead electroencephalogram and blood oxygen information measuring device provided by the embodiment;
the high-precision oximeter is connected with a controller of the forehead electroencephalogram and blood oxygen information measuring device through the first interface; the event stimulator is connected with the controller of the forehead electroencephalogram and blood oxygen information measuring device through the second interface.
Thus, the forehead electroencephalogram and blood oxygen information measurement system disclosed by the invention utilizes the high-precision blood oxygen meter to measure the brain blood oxygen information of the tested person as a reference standard, automatically calibrates target parameters, and solves the problem that the brain blood oxygen measurement optimization parameters of different tested persons are inconsistent and the system parameters need to be manually adjusted; measuring brain blood oxygen information of a tested person by using a high-precision oximeter as a reference standard, controlling a stepping motor by using a closed-loop control technology aiming at different tested objects to obtain an optimized position, an optimized contact force and an optimized luminous intensity of a functional near infrared emitting diode and a functional near infrared receiving diode which are in contact with the brain of the tested person, searching for an optimized target parameter for measuring the brain blood oxygen information of the tested person, and solving the problem of troublesome manual adjustment of system parameters; the temperature calibration and compensation are carried out on the cerebral blood oxygen measurement result by utilizing the data of the temperature sensor, so that the problem that the blood oxygen measurement result is inaccurate when the ambient temperature of a tested person changes greatly during the test is solved; and the synchronous time of the stimulation event and the electroencephalogram signal under the specific stimulation event is automatically obtained by using a matched filter and an accumulation algorithm, so that the problem that the parameter deviation of the synchronous time of the stimulation event and the electroencephalogram signal under the specific stimulation event is large for different testees is solved.
Exemplary method
Based on the same conception, referring to fig. 2, the invention also provides a parameter optimizing method; the parameter optimizing method comprises the following steps:
step S201, the target parameters of the infrared detection module are controlled to be changed within a preset range; for each target parameter, calculating first difference information between a second blood oxygen detection result and a first blood oxygen detection result according to a first blood oxygen detection result measured by an infrared detection module and a second blood oxygen detection result measured by the high-precision oximeter at the same time; determining a target parameter corresponding to the minimum first difference information as an optimal parameter;
specifically, step S201 includes: controlling the infrared detection module to move within a preset range through the movement module; for each position, calculating first difference information between a second blood oxygen detection result and a first blood oxygen detection result according to a first blood oxygen detection result measured by an infrared detection module and a second blood oxygen detection result measured by the high-precision oximeter at the same time; determining the position corresponding to the minimum first difference information as an optimal position, and determining the position parameter corresponding to the optimal position as an optimal position parameter; controlling the contact force of the infrared detection module to change within a preset range through the mobile module; for each force, calculating second difference information between a third blood oxygen detection result and a fourth blood oxygen detection result measured by the infrared detection module and a fourth blood oxygen detection result measured by the high-precision oximeter at the same time; determining the contact force corresponding to the smallest second difference value information as the optimal contact force, and determining the force parameter corresponding to the optimal contact force as the optimal force parameter;
It should be noted that, step S201 further includes adjustment of other target parameters, this is not exemplified, and will be described later.
Step S202, applying standard stimulation events to the brain of a tested person through an event stimulator so as to activate different areas of the brain, and collecting brain electrical signals of the brain of the tested person through an electroencephalogram collection module; based on the time of applying the stimulation event and the brain electrical signals of the brain of the tested person, the synchronous time parameter of the stimulation event and the brain electrical signals is calculated by using a matched filter and a summation algorithm.
Step S203, acquiring temperature information acquired by the temperature sensor; based on the temperature information, a temperature compensation coefficient is determined.
The parameter optimizing method comprises the following steps: parameter optimization utilizes the high-precision oximeter to measure the brain blood oxygen information of a tested person as a reference standard, automatically calibrates target parameters, and solves the problem that the brain blood oxygen measurement optimization parameters of different tested persons are inconsistent and the system parameters need to be manually adjusted; measuring brain blood oxygen information of a tested person by using a high-precision oximeter as a reference standard, controlling a stepping motor by using a closed-loop control technology aiming at different tested objects to obtain an optimized position, an optimized contact force and an optimized luminous intensity of a functional near infrared emitting diode and a functional near infrared receiving diode which are in contact with the brain of the tested person, searching for an optimized target parameter for measuring the brain blood oxygen information of the tested person, and solving the problem of troublesome manual adjustment of system parameters; the temperature calibration and compensation are carried out on the cerebral blood oxygen measurement result by utilizing the data of the temperature sensor, so that the problem that the blood oxygen measurement result is inaccurate when the ambient temperature of a tested person changes greatly during the test is solved; and the synchronous time of the stimulation event and the electroencephalogram signal under the specific stimulation event is automatically obtained by using a matched filter and an accumulation algorithm, so that the problem that the parameter deviation of the synchronous time of the stimulation event and the electroencephalogram signal under the specific stimulation event is large for different testees is solved.
Specifically, referring to fig. 3, the forehead electroencephalogram and blood oxygen information measurement device performs a parameter optimizing method and includes the following three processes when in use: a cerebral blood oxygen measurement calibration flow, an automatic cerebral blood oxygen measurement parameter optimizing flow, and an electroencephalogram signal and blood oxygen signal fusion processing flow.
Firstly, measuring cerebral blood oxygen of a tested object through a high-precision oximeter, and establishing a calibration basis of a blood oxygen measuring device; secondly, adjusting system parameters of the blood oxygen measuring device, measuring blood oxygen information, and comparing a measurement result with a measurement result of a high-precision oximeter; thirdly, the parameters corresponding to the minimum error between the measurement result of the blood oxygen measuring device and the measurement result of the high-precision oximeter are the optimized system parameters; and finally, stimulating the brain of the tested person through an event stimulator, automatically obtaining the synchronous time of a stimulation event and an electroencephalogram signal by using a matched filter and an accumulation algorithm, and synchronously acquiring blood oxygen information and electroencephalogram information fusion of the brain of the tested person by using a calibrated blood oxygen measuring device.
The cerebral blood oxygen measurement calibration flow is mainly used for calibrating system parameters of the device and establishing adjustment reference information of the system parameters of the device.
The cerebral blood oxygen measurement calibration flow is as follows: before the experiment starts, the tested object is in a quiet surrounding environment, a stimulation scene (such as a standard image scene) is set by an event stimulator to stimulate the tested person, and the blood oxygen information of the tested person is measured by using a high-precision oximeter and is used as the basis of a reference experiment.
The automatic optimizing flow of the cerebral blood oxygen measurement parameters is as follows:
firstly, setting a range [ D1, D2] of the distance between a functional near infrared emitting diode and a functional near infrared receiving diode and an initial value D1 by taking a blood oxygen measurement result of a cerebral blood oxygen measurement calibration process as a standard; a functional near infrared emitting diode, a functional near infrared receiving diode, a brain contact force range [ F1, F2] of a tested person and an initial value F1; the method comprises the steps of using the same experimental scene (such as a standard image scene) of a cerebral blood oxygen measurement calibration process to stimulate the brain of a tested person, and using a controller to measure blood oxygen information of the brain of the tested person, wherein the luminous power range [ P1, P2] and the initial value P1 of a functional near infrared emitting diode, the detection threshold range [ TH1, TH2] and the initial value TH1 of a functional near infrared receiving diode, and the sampling frequency range [ f1, f2] and the initial value f1 of the functional near infrared receiving diode;
secondly, measuring brain blood oxygen information of a tested object under the same test condition as the first STEP, fixing brain contact force F1 between a functional near infrared receiving diode and the tested object, fixing luminous power P1 of the functional near infrared receiving diode, setting a detection threshold TH1 and sampling frequency F1 of the functional near infrared receiving diode, setting interval changes of the functional near infrared receiving diode and the functional near infrared receiving diode as D1, D1+n1 as STEP_D, … and D2 in sequence, wherein STEP_D= (D2-D1)/N1, n1=0, 1, …, N1 interval D1, D1+n1 as STEP_D, … and D2 correspond to (N1+1) blood oxygen measurement results, comparing the (N1+1) blood oxygen measurement results with the blood oxygen measurement results of the first STEP brain blood oxygen measurement calibration flow, and recording the parameter with the minimum error as set S1;
Thirdly, measuring cerebral blood oxygen information of a tested object under the same test condition as the first STEP, fixing the distance D1 between a functional near infrared emitting diode and a functional near infrared receiving diode, setting the detection threshold TH1 and the sampling frequency F1 of the functional near infrared emitting diode, setting the change of the brain contact force of the functional near infrared emitting diode, the functional near infrared receiving diode and the tested object to be F1, F1+n2, STEP_F, … and D2 in sequence, wherein STEP_F= (F2-F1)/N2, n2=0, 1, …, N2 distance F1, F1+n2, STEP_F, … and F2 correspond to (N2+1) blood oxygen measurement results, and comparing the (N2+1) blood oxygen measurement results with the blood oxygen measurement result of the first cerebral blood oxygen measurement flow, wherein the parameter with the minimum recording error is set S2;
measuring cerebral blood oxygen information of a tested object under the same test condition as the first STEP, fixing the distance D1 between the functional near infrared emitting diode and the functional near infrared receiving diode, wherein the functional near infrared emitting diode, the functional near infrared receiving diode and the tested object are in contact with the brain, the strength F1 is the detection threshold TH1 and the sampling frequency F1 of the functional near infrared receiving diode, the change of the luminous power P1 of the functional near infrared emitting diode is P1, P1+n3, STEP_P, … and P2 in sequence, STEP_P= (P2-P1)/N3, n3=0, 1, …, N3 distance P1, P1+n3, STEP_P, … and P2 are corresponding to (N3+1) blood oxygen measurement results, and comparing the (N3+1) blood oxygen measurement results with the blood oxygen measurement result of the first cerebral blood oxygen measurement calibration flow, and the parameter set with the minimum recording error is S3;
Fifthly, measuring cerebral blood oxygen information of a tested object under the same test condition as the first STEP, fixing a distance D1 between a functional near infrared emitting diode and a functional near infrared receiving diode, wherein the luminous power P1 of the functional near infrared emitting diode, the luminous power F1 of the functional near infrared emitting diode, the sampling frequency F1 of the functional near infrared receiving diode and the brain contact force F1 of the tested object, setting the change of a detection threshold TH1 of the functional near infrared receiving diode to be TH1, TH1+n4, STEP_TH, … and TH2 in sequence, wherein STEP_TH= (TH 2-TH 1)/N4, n4=0, 1, …, N4 distance TH1, TH1+n4, STEP_TH1, … and TH2 correspond to (N4+1) blood oxygen measurement results, comparing the (N4+1) blood oxygen measurement results with the blood oxygen measurement results of the first cerebral blood oxygen measurement calibration flow, and recording the parameter when the error is the minimum is S4;
STEP six, measuring brain blood oxygen information of a tested object under the same test condition as the STEP one, fixing a distance D1 between a functional near infrared emitting diode and a functional near infrared receiving diode, wherein the functional near infrared emitting diode emits light to power P1, the functional near infrared emitting diode emits light to power F1, a detection threshold TH1 of the functional near infrared receiving diode is arranged, the change of the detection threshold F1 of the functional near infrared receiving diode is F1, f1+n5 x STEP_f, … and F2 in sequence, STEP_f= (F2-F1)/N5, n5=0, 1, …, N5 distance F1, f1+n5 x STEP_f, … and F2 correspond to (N5+1) blood oxygen measurement results, comparing the (N5+1) blood oxygen measurement results with the blood oxygen measurement results of the brain blood oxygen measurement calibration flow of the first STEP, and recording the parameter with the minimum error is S5;
Seventh, comparing the minimum value of the blood oxygen measurement result error of the second step to the seventh step, searching to obtain an optimized parameter set S of the whole system, wherein the set S comprises the distance D between the optimized functional near infrared emitting diode and the functional near infrared receiving diode, the light emitting power P of the optimized functional near infrared emitting diode, the brain contact force F of the optimized functional near infrared emitting diode, the optimized functional near infrared receiving diode and the brain of the tested person, the detection threshold TH of the optimized functional near infrared receiving diode, and the sampling frequency F of the optimized functional near infrared receiving diode;
eighth, after the optimized parameter information of the device is obtained, the controller drives the circular motion to be converted into the three-dimensional motion device to drive the functional near infrared emitting diode and the functional near infrared receiving diode to move by controlling the three-axis stepping motor, and closed-loop control of the functional near infrared emitting diode and the functional near infrared receiving diode is realized by utilizing the position information fed back by the stepping motor position measuring module, so that the contact positions and the force between the functional near infrared emitting diode and the functional near infrared receiving diode and the brain of a tested person are adjusted.
Referring to fig. 4, the main flow of the extraction algorithm for determining the synchronous time parameter of the stimulation event and the electroencephalogram signal by the forehead electroencephalogram and blood oxygen information measurement apparatus is as follows: the main flow of the extraction algorithm of the synchronous time of the stimulation event and the brain electrical signal is as follows:
Firstly, taking an electroencephalogram response signal under a standard stimulation event as an initial template, designing a corresponding matched filter according to the initial template, and setting the frequency of stimulation as M times;
secondly, selecting a stimulation event of the first step standard as a stimulation input to be applied to the brain of a tested person through an event stimulator, enabling an electroencephalogram signal acquired by electroencephalogram acquisition equipment to be used as the input of a matched filter designed in the first step to obtain the output of the filter, and detecting the position of the maximum value of the response of the matched filter through a maximum value position detection module to obtain an estimated value t of the synchronization time of the stimulation event and the electroencephalogram signal;
thirdly, sending the acquired electroencephalogram signal delay time t to an accumulation average module, wherein the output result of the accumulation average module is used for updating a matched filter;
and fourthly, repeating the second step to the third step for M times, and accumulating the output real brain electrical signals of the averaging module.
Specifically, if the output of the matched filter is greater than a set threshold, the control switch is closed, and the original electroencephalogram signal delay time t is sent to the accumulation average module; and if the output of the matched filter is smaller than or equal to the set threshold, controlling the switch to be opened, and repeatedly executing the second to fourth steps of processes by the algorithm.
Finally, applying event stimulation to the tested person through the event stimulator, acquiring brain electrical information by the brain electrical acquisition module, synchronously acquiring light information by the functional near infrared receiving diode and sending the light information to the receiving signal detection module, converting the light signal into a digital signal by the receiving signal detection module, sending the digital signal to the controller, obtaining corresponding blood oxygen information by the controller, and then fusing the brain electrical information and the blood oxygen information synchronously acquired under the stimulation event by the controller, so that the brain electrical information and the blood oxygen information can be used for diagnosing diseases, researching physiological characteristics and controlling brain-computer interfaces.
Exemplary apparatus
The invention also provides a parameter optimizing device which is applied to the forehead electroencephalogram and blood oxygen information measuring device and comprises the following components:
the first optimizing module is used for controlling the target parameters of the infrared detection module to change within a preset range; for each target parameter, calculating first difference information between a second blood oxygen detection result and a first blood oxygen detection result according to a first blood oxygen detection result measured by an infrared detection module and a second blood oxygen detection result measured by the high-precision oximeter at the same time; determining a target parameter corresponding to the minimum first difference information as an optimal parameter;
The second optimizing module is used for applying standard stimulation events to the brain of the tested person through the event stimulator so as to activate different areas of the brain, and collecting brain electrical signals of the brain of the tested person through the brain electrical collecting module; based on the time of applying the stimulation event and the brain electrical signals of the brain of the tested person, the synchronous time of the stimulation event and the brain electrical signals is calculated by using a matched filter and a summation algorithm.
It should be noted that, for the places where the parameter optimizing apparatus is not clear, reference may be made to the description of the "exemplary method" and a detailed description thereof will not be given here.
Exemplary electronic device
Next, an electronic device according to an embodiment of the present invention is described with reference to fig. 5. Fig. 5 illustrates a block diagram of an electronic device according to an embodiment of the invention.
As shown in fig. 5, the electronic device 500 includes one or more processors 510 and memory 520.
Processor 510 may be a Central Processing Unit (CPU) or other form of processing unit having data processing and/or instruction execution capabilities, and may control other components in electronic device 500 to perform desired functions.
Memory 520 may include one or more computer program products that may include various forms of computer-readable storage media, such as volatile memory and/or non-volatile memory. The volatile memory may include, for example, random Access Memory (RAM) and/or cache memory (cache), and the like. The non-volatile memory may include, for example, read Only Memory (ROM), hard disk, flash memory, and the like. One or more computer program instructions may be stored on the computer readable storage medium that can be executed by the processor 510 to implement the parameter optimizing methods and/or other desired functions of the various embodiments of the present invention described above. Various contents such as category correspondence may also be stored in the computer-readable storage medium.
In one example, the electronic device 500 may further include: an input device 530 and an output device 540, which are interconnected by a bus system and/or other forms of connection mechanisms (not shown).
In addition, the input device 530 may also include, for example, a keyboard, mouse, interface, etc. The output device 540 may output various information including analysis results and the like to the outside. The output device 540 may include, for example, a display, speakers, a printer, and a communication network and remote output devices connected thereto, etc.
Of course, only some of the components of the electronic device that are relevant to the present invention are shown in fig. 5 for simplicity, components such as buses, input/output interfaces, etc. being omitted. In addition, the electronic device may include any other suitable components depending on the particular application.
Exemplary computer program product and computer readable storage Medium
In addition to the methods and apparatus described above, embodiments of the invention may also be a computer program product comprising computer program instructions which, when executed by a processor, cause the processor to perform the steps in a method of optimizing parameters according to various embodiments of the invention described in the "exemplary methods" section of this specification.
The computer program product may write program code for performing operations of embodiments of the present invention in any combination of one or more programming languages, including an object oriented programming language such as Java, C++ or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computing device, partly on the user's device, as a stand-alone software package, partly on the user's computing device, partly on a remote computing device, or entirely on the remote computing device or server.
Furthermore, embodiments of the present invention may also be a computer-readable storage medium, having stored thereon computer program instructions, which when executed by a processor, cause the processor to perform the steps in a parameter optimizing method according to various embodiments of the present invention described in the "exemplary method" section of the present specification.
The computer readable storage medium may employ any combination of one or more readable media. The readable medium may be a readable signal medium or a readable storage medium. The readable storage medium may include, for example, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or a combination of any of the foregoing. More specific examples (a non-exhaustive list) of the readable storage medium would include the following: an electrical connection having one or more wires, a portable disk, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
The foregoing description has been presented for purposes of illustration and description. Furthermore, this description is not intended to limit embodiments of the invention to the form disclosed herein. Although a number of example aspects and embodiments have been discussed above, a person of ordinary skill in the art will recognize certain variations, modifications, alterations, additions, and subcombinations thereof.
Claims (10)
1. A forehead electroencephalogram and blood oxygen information measurement apparatus, characterized by comprising:
the infrared detection module is used for radiating the emitted infrared light to the brain of the tested person and receiving the light intensity signal reflected by the brain;
the moving module is used for fixing the infrared detection module and controlling the infrared detection module to move;
the brain electricity acquisition module is used for acquiring brain electricity signals of the brain of the tested person;
the controller is respectively in communication connection with the infrared detection module, the mobile module and the electroencephalogram acquisition module so as to control the infrared detection module and the mobile module to measure blood oxygen information and control the electroencephalogram acquisition module to measure forehead electroencephalogram;
the controller comprises a first interface, wherein the first interface is used for being connected with a preset high-precision oximeter so as to optimize target parameters based on the high-precision oximeter;
The target parameters comprise position parameters, strength parameters, sampling frequency parameters, detection threshold parameters and luminous intensity parameters;
the controller comprises a second interface, and is used for being connected with a preset event stimulator through the second interface so as to carry out optimization of the synchronous time parameters of the electroencephalogram acquisition module based on the event stimulator.
2. A forehead electroencephalogram and blood oxygen information measurement apparatus according to claim 1, wherein said infrared detection module comprises: the device comprises a near infrared emitting diode power driving circuit, a functional near infrared emitting diode, a functional near infrared receiving diode and a received signal detection module;
the near infrared emitting diode power driving circuit is respectively connected with the controller and the functional near infrared emitting diode;
the receiving signal detection module is respectively connected with the controller and the functional near infrared receiving diode;
the controller is used for driving the functional near infrared emitting diode to emit light rays to a target area of a tested person through the near infrared emitting diode power driving circuit;
the functional near infrared receiving diode is used for receiving the light reflected by the target area and sending a light intensity signal to the controller through the receiving signal detection module;
The controller is used for determining blood oxygen information based on the light intensity signal and lambert beer law.
3. A forehead electroencephalogram and blood oxygen information measurement apparatus according to claim 2, wherein said mobile module comprises: the three-axis stepping motor, the stepping motor position measuring module and the circular motion are converted into a three-dimensional motion device;
the three-axis stepping motor is respectively in communication connection with the stepping motor position measuring module, the device for converting the circular motion into the three-dimensional motion and the controller;
the circular motion is converted into a three-dimensional motion device which is used for fixing the functional near infrared emitting diode and the functional near infrared receiving diode;
the controller is used for converting the circular motion of the three-axis stepping motor into three-dimensional curve motion through the three-axis stepping motor and the circular motion conversion device, and adjusting the contact positions and the force between the functional near infrared emitting diode and the functional near infrared receiving diode and the tested person through the circular motion conversion device;
the stepping motor position measurement module is used for detecting actual movement position quantities of the functional near infrared emitting diode and the functional near infrared receiving diode and feeding back the actual movement position quantities to the controller;
The controller performs closed-loop control on the three-axis stepping motor based on the actual movement position quantity.
4. A forehead electroencephalogram and blood oxygen information measurement apparatus according to claim 1, further comprising: a temperature sensor;
the temperature sensor is in communication connection with the controller and is used for acquiring temperature information and sending the acquired temperature information to the controller;
the controller is further configured to determine a temperature compensation coefficient based on the temperature information;
the temperature compensation coefficient is used for performing temperature compensation on blood oxygen information obtained by detection based on the infrared detection module.
5. A forehead electroencephalogram and blood oxygen information measurement system, comprising: a high-precision oximeter, an event stimulator, and the forehead electroencephalogram and blood oxygen information measurement apparatus according to any one of claims 1 to 4;
the high-precision oximeter is connected with a controller of the forehead electroencephalogram and blood oxygen information measuring device through the first interface; the event stimulator is connected with the controller of the forehead electroencephalogram and blood oxygen information measuring device through the second interface.
6. A parameter optimizing method applied to the forehead electroencephalogram and blood oxygen information measuring apparatus according to any one of claims 1 to 4, characterized by comprising:
The target parameters of the infrared detection module are controlled to be changed within a preset range; for each target parameter, calculating first difference information between a second blood oxygen detection result and a first blood oxygen detection result according to a first blood oxygen detection result measured by an infrared detection module and a second blood oxygen detection result measured by the high-precision oximeter at the same time; determining a target parameter corresponding to the minimum first difference information as an optimal parameter;
applying standard stimulation events to the brain of a tested person through an event stimulator so as to activate different areas of the brain, and collecting brain electrical signals of the brain of the tested person through an electroencephalogram collection module; based on the time of applying the stimulation event and the brain electrical signals of the brain of the tested person, the synchronous time parameter of the stimulation event and the brain electrical signals is calculated by using a matched filter and a summation algorithm.
7. The parameter optimizing method according to claim 6, characterized by further comprising, when applied to the forehead electroencephalogram and blood oxygen information measuring apparatus according to claim 4:
acquiring temperature information acquired by the temperature sensor;
based on the temperature information, a temperature compensation coefficient is determined.
8. A parameter optimizing apparatus applied to the forehead electroencephalogram and blood oxygen information measuring apparatus according to any one of claims 1 to 4, characterized by comprising:
the first optimizing module is used for controlling the target parameters of the infrared detection module to change within a preset range; for each target parameter, calculating first difference information between a second blood oxygen detection result and a first blood oxygen detection result according to a first blood oxygen detection result measured by an infrared detection module and a second blood oxygen detection result measured by the high-precision oximeter at the same time; determining a target parameter corresponding to the minimum first difference information as an optimal parameter;
the second optimizing module is used for applying standard stimulation events to the brain of the tested person through the event stimulator so as to activate different areas of the brain, and collecting brain electrical signals of the brain of the tested person through the brain electrical collecting module; based on the time of applying the stimulation event and the brain electrical signals of the brain of the tested person, the synchronous time of the stimulation event and the brain electrical signals is calculated by using a matched filter and a summation algorithm.
9. An electronic device, comprising:
a processor and a memory for storing a program executable by the processor;
The processor is configured to implement the parameter optimizing method according to any one of claims 6 to 7 by running a program in the memory.
10. A computer readable storage medium, characterized in that the computer readable storage medium has stored thereon a computer program which, when executed by a processor, causes the processor to perform the parameter optimizing method according to any of claims 6 to 7.
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