CN116439378A - Rapidly disintegrating effervescent tablet composition and preparation method thereof - Google Patents
Rapidly disintegrating effervescent tablet composition and preparation method thereof Download PDFInfo
- Publication number
- CN116439378A CN116439378A CN202310385940.6A CN202310385940A CN116439378A CN 116439378 A CN116439378 A CN 116439378A CN 202310385940 A CN202310385940 A CN 202310385940A CN 116439378 A CN116439378 A CN 116439378A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- parts
- effervescent tablet
- acid
- die
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 47
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 235000013305 food Nutrition 0.000 claims abstract description 25
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical group OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 20
- 239000002253 acid Substances 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 229930003270 Vitamin B Chemical group 0.000 claims abstract description 12
- 239000003513 alkali Substances 0.000 claims abstract description 12
- 239000011720 vitamin B Chemical group 0.000 claims abstract description 12
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 12
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 11
- 239000003765 sweetening agent Substances 0.000 claims abstract description 11
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 10
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 10
- 239000011718 vitamin C Substances 0.000 claims abstract description 10
- 239000000049 pigment Substances 0.000 claims abstract description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 28
- 239000000314 lubricant Substances 0.000 claims description 21
- 239000003826 tablet Substances 0.000 claims description 20
- 238000005507 spraying Methods 0.000 claims description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 14
- 235000019359 magnesium stearate Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 238000007599 discharging Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 10
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 4
- 108010011485 Aspartame Proteins 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 4
- 239000004376 Sucralose Substances 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 229930003451 Vitamin B1 Natural products 0.000 claims description 4
- 229930003779 Vitamin B12 Natural products 0.000 claims description 4
- 229930003471 Vitamin B2 Natural products 0.000 claims description 4
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 4
- 229960004998 acesulfame potassium Drugs 0.000 claims description 4
- 239000000619 acesulfame-K Substances 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 4
- 239000001530 fumaric acid Substances 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
- 239000000845 maltitol Substances 0.000 claims description 4
- 235000010449 maltitol Nutrition 0.000 claims description 4
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 4
- 229940035436 maltitol Drugs 0.000 claims description 4
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 4
- 229960002477 riboflavin Drugs 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 235000010356 sorbitol Nutrition 0.000 claims description 4
- 229960002920 sorbitol Drugs 0.000 claims description 4
- 235000019408 sucralose Nutrition 0.000 claims description 4
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 229960003495 thiamine Drugs 0.000 claims description 4
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- 235000010374 vitamin B1 Nutrition 0.000 claims description 4
- 239000011691 vitamin B1 Substances 0.000 claims description 4
- 235000019163 vitamin B12 Nutrition 0.000 claims description 4
- 239000011715 vitamin B12 Substances 0.000 claims description 4
- 235000019164 vitamin B2 Nutrition 0.000 claims description 4
- 239000011716 vitamin B2 Substances 0.000 claims description 4
- 235000019158 vitamin B6 Nutrition 0.000 claims description 4
- 239000011726 vitamin B6 Substances 0.000 claims description 4
- 229940011671 vitamin b6 Drugs 0.000 claims description 4
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 3
- 239000004386 Erythritol Substances 0.000 claims description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 3
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 3
- 239000004384 Neotame Substances 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 3
- 238000000889 atomisation Methods 0.000 claims description 3
- 229960002685 biotin Drugs 0.000 claims description 3
- 235000020958 biotin Nutrition 0.000 claims description 3
- 239000011616 biotin Substances 0.000 claims description 3
- XFLVBMBRLSCJAI-UHFFFAOYSA-N biotin amide Natural products N1C(=O)NC2C(CCCCC(=O)N)SCC21 XFLVBMBRLSCJAI-UHFFFAOYSA-N 0.000 claims description 3
- 235000019414 erythritol Nutrition 0.000 claims description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 3
- 229940009714 erythritol Drugs 0.000 claims description 3
- 229960000304 folic acid Drugs 0.000 claims description 3
- 235000019152 folic acid Nutrition 0.000 claims description 3
- 239000011724 folic acid Substances 0.000 claims description 3
- 229930189775 mogroside Natural products 0.000 claims description 3
- 235000019412 neotame Nutrition 0.000 claims description 3
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 claims description 3
- 108010070257 neotame Proteins 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000033001 locomotion Effects 0.000 description 7
- 238000011049 filling Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000002585 base Substances 0.000 description 3
- 229960004106 citric acid Drugs 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004395 L-leucine Substances 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229960004543 anhydrous citric acid Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/68—Acidifying substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the technical field of foods, in particular to a rapidly disintegrating effervescent tablet composition and a preparation method thereof. The specific technical scheme is as follows: the rapidly disintegrating effervescent tablet composition comprises the following components in parts by weight (or mass percent): 35-40 parts of acidity regulator acid source, 15-25 parts of acidity regulator alkali source, 1-3 parts of food essence and pigment, 0.01-2 parts of vitamin C and vitamin B group, 25-30 parts of sweetener and 10-30 parts of food raw material. The invention solves the problems of longer disintegration time and large amount of bubbles generated in the existing effervescent tablet.
Description
Technical Field
The invention relates to the technical field of foods, in particular to a rapidly disintegrating effervescent tablet composition and a preparation method thereof.
Background
The effervescent tablet is a tablet prepared by taking proper acid and alkali as disintegrating agents. The effervescent tablet can generate a large amount of carbon dioxide gas after being filled with water so as to be dissolved rapidly, and the medicine has the advantages of rapid effect, high bioavailability, convenient carrying and low cost, thus the development is faster in recent years. The effervescent tablets commonly used in clinic at present are mainly oral effervescent tablets. The oral effervescent tablet is suitable for children, the elderly and patients incapable of swallowing solid preparations, and the oral effervescent tablet with better quality is a cup of sweet and sour delicious beverage after effervescent.
The acid-base composition in the effervescent tablet plays a very important role in the preparation, disintegration and stability of the effervescent tablet, such as improper selection can influence the preparation and the properties of the product. The common acid sources of the effervescent tablets in the market at present are citric acid, DL-malic acid, fumaric acid, lactic acid, boric acid, inorganic mineral acid, tartaric acid, phosphoric acid and the like. The alkali source is sodium carbonate or sodium bicarbonate. However, due to different acid-base collocations and the selection of auxiliary materials, the disintegration time of the effervescent tablet is basically about 5 minutes or even longer, and a large amount of bubbles can be generated when the multi-dimensional effervescent tablet is disintegrated.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a rapidly disintegrating effervescent tablet composition and a preparation method thereof, which solve the problems of longer disintegration time and large amount of bubbles generated in the existing effervescent tablet.
In order to achieve the above purpose, the invention is realized by the following technical scheme:
the invention discloses a rapidly disintegrating effervescent tablet composition, which comprises the following components in parts by weight:
35-40 parts of acidity regulator acid source, 15-25 parts of acidity regulator alkali source, 1-3 parts of food essence and pigment, 0.01-2 parts of vitamin C and vitamin B group, 25-30 parts of sweetener and 10-30 parts of food raw material.
Preferably, the acid source of the acidity regulator is one or more of citric acid, DL-malic acid, tartaric acid, fumaric acid, inorganic mineral acid and phosphoric acid; the acidity regulator alkali source is one or two of sodium carbonate and sodium bicarbonate; the vitamin B group is one or more of vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, biotin and nicotinamide, and the sweetener is one or more of sucralose, aspartame, acesulfame potassium, neotame, stevioside, mogroside, maltitol, sorbitol and erythritol.
Correspondingly, the preparation method of the rapidly disintegrating effervescent tablet composition comprises the following steps:
(1) Mixing and granulating an acidity regulator acid source, food raw materials and food essence to obtain granules;
(2) Mixing vitamin C, vitamin B and sweetener in equal incremental manner to obtain premix;
(3) Mixing the premix, the acidity regulator alkali source and the granular material to obtain a mixed material, and tabletting by using a tablet press; before tabletting, spraying lubricant into the through holes of the middle die, the upper punch and the lower punch on the tablet press through spraying equipment, sucking the lubricant out through air extracting equipment, adding a mixture into the through holes of the middle die, and tabletting by the tablet press after the feeding is completed.
Preferably, the lubricant is magnesium stearate, the mesh number is 200-300 mesh, and the spraying pressure is 0.2-0.6 MPa.
Preferably, the tablet press comprises a middle die, an upper fixed die and a lower fixed die are respectively arranged above and below the middle die, the upper punch and the lower punch are respectively fixed on the upper fixed die and the lower fixed die, the upper fixed die, the lower fixed die and the middle die are fixed through a bracket, the lower fixed die is driven to move by a motor, a discharging block communicated with an atomization powder pipe on the spraying equipment is arranged on the middle die, a mixture feeding block is further arranged on the middle die, and an air inlet channel of the air extraction equipment is integrated on the feeding block.
Preferably, the upper fixing mould and the lower fixing mould are respectively vertically and penetratingly provided with a positioning hole, the positioning holes are correspondingly arranged with the through holes, and the upper punch and the lower punch are respectively arranged in the positioning holes and move up and down in the positioning holes.
Preferably, the bottom of the positioning hole on the upper fixed mould and the top of the positioning hole on the lower fixed mould are respectively provided with a positioning ring, and the upper punch and the lower punch respectively penetrate through the positioning rings and are fixed through springs.
The invention has the following beneficial effects:
the effervescent tablet prepared by omitting polyethylene glycol and L-leucine achieves the same effect, the punch is not sticky during tabletting, and meanwhile, the disintegration time of the effervescent tablet is controlled by controlling the proportion of each component, so that the disintegration time of the effervescent tablet is greatly shortened. In addition, the atomized magnesium stearate is adopted to prepare the effervescent tablet, and the effervescent tablet is extracted during tabletting, so that the residue of magnesium stearate is avoided, and the disintegration time, color, taste and the like of the effervescent tablet are not influenced. The invention realizes the production of the high-efficacy refreshing functional food with low cost, and has intuitive and definite flow and high efficiency.
Drawings
FIG. 1 is a flowchart of the overall tabletting process;
fig. 2 is a schematic view of the structure of the tablet press (the arrangement of the middle die, the upper fixed die, the lower fixed die, and the upper and lower punches in the front view), in which the arrow is the direction of movement;
in the figure: the device comprises a discharge block 5, a middle die 11, an upper punch 12, a lower punch 13, a through hole 14, an upper fixed die 15, a lower fixed die 16, a bracket 17, a feeding block 18, a positioning hole 19, a positioning ring 20, a spring 21 and a scraping blade 22.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The technical means used in the examples are conventional means well known to those skilled in the art unless otherwise indicated.
1. The invention discloses a rapidly disintegrating effervescent tablet composition, which comprises the following components in parts by weight:
35-40 parts of acidity regulator acid source, 15-25 parts of acidity regulator alkali source, 1-3 parts of food essence and pigment, 0.01-2 parts of vitamin C and vitamin B group, 25-30 parts of sweetener and 10-30 parts of food raw material.
The acidity regulator acid source is one or more of citric acid, DL-malic acid, tartaric acid, fumaric acid, inorganic mineral acid and phosphoric acid; the acidity regulator alkali source is one or two of sodium carbonate and sodium bicarbonate; the vitamin B group is one or more of vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, biotin and nicotinamide, and is required to be stored in a dark place, and the sweetener is one or more of sucralose, aspartame, acesulfame potassium, neotame, stevioside, mogroside, maltitol, sorbitol and erythritol. Wherein, the acidity regulator acid source is crushed to be more than or equal to 60 meshes when in use, so that the tablet is more uniform and attractive.
The food raw materials are plant extract raw materials, new food raw materials, common food raw materials, edible flowers and the like, accord with the regulations of the new food raw materials, medical and edible sources, common food and fruit and vegetable powder (solid beverage), and can ensure that the effervescent tablet does not have agglomeration phenomenon when dissolved.
2. The invention also discloses a preparation method of the rapidly disintegrating effervescent tablet composition, which comprises the following steps:
(1) Mixing and granulating an acidity regulator acid source, food raw materials and food essence to obtain granules; in the effervescent tablet, an acid source, food essence and food raw materials (optionally pigment can be added) can be coarsely embedded during mixing granulation, so that the acid source and the base can be prevented from reacting during tabletting.
(2) Mixing vitamin C, vitamin B and sweetener in equal incremental manner to obtain premix; equal incremental mixing refers to equal incremental mixing of the total amount of vitamin B and vitamin C with sweetener, and can ensure uniform content of vitamin B and vitamin C in each effervescent tablet.
(3) Mixing the premix, the acidity regulator alkali source and the granules to obtain a mixture, and tabletting by using a tablet press, wherein the food auxiliary materials can be added according to the needs, and the addition amount is 10-20 parts by weight; before tabletting, spraying lubricant into the through holes 14 of the middle die 11, the upper punch 12 and the lower punch 13 on the tablet press through a spraying device, sucking the lubricant out through an air extracting device, simultaneously adding a mixture into the through holes 14 of the middle die, and tabletting the tablet press after the feeding is completed. Wherein the lubricant is magnesium stearate with the mesh number of 200-300 meshes and the spraying pressure of 0.2-0.6 MPa. The magnesium stearate is sprayed into the upper punch, the lower punch and the middle die in a mist form, the middle die is vertically provided with a through hole, the lower punch is arranged below the middle die, the upper punch is arranged above the middle die and corresponds to the through hole, and when the mixture or the lubricant is sprayed, the lower punch moves upwards until the bottom of the through hole is closed, namely the bottom of the through hole is just closed by the lower punch, or the lower punch part can be used in the through hole. The particle size of the magnesium stearate is smaller than that of the premix, so that the premix can not be sucked out when the air extracting device sucks the magnesium stearate, and the pressure of the air extracting device is adjusted in real time according to the particle size of the magnesium stearate.
Further, the air extraction device comprises, but is not limited to, an exhaust fan, a hose is communicated with the air inlet of the air extraction device, the inlet end of the hose is a shrinkage mouth, and a plurality of hoses can be arranged according to requirements. The inlet end of the hose is located above or near the side wall of the through hole. The pressure of the air extraction equipment is controlled, so that the lubricant is controlled to be sucked out, the premix is not sucked out, and the device is specifically arranged according to actual conditions. When the air extraction equipment is started, the mixture is added into the through hole, after the feeding is completed, the air extraction equipment and the feeding equipment are removed, and meanwhile, the upper punch and the lower punch are started to move towards the inside of the through hole, so that tabletting is completed.
Further, the spraying equipment comprises a double-screw output mechanism, and a storage hopper is arranged above the double-screw output mechanism and used for storing the lubricant. The discharge end of the double-screw output mechanism is positioned in the guide cylinder, the bottom end of the guide cylinder is connected with an atomizing sprayer, the atomizing sprayer is communicated with a discharging block 5 through an atomizing powder pipe, and the top and the bottom of the discharging block 5 are correspondingly provided with powder spraying ports. It should be noted that: the double-screw output mechanism is existing equipment, and is driven by a motor to convey the lubricant into the guide cylinder. The guide cylinder is vertically arranged, and the screw rod of the double-screw output mechanism transversely stretches into the guide cylinder and is fixed. When the device is used, the discharging block is positioned on the through hole, and lubricant is sprayed into the upper punch and the through hole through the powder spraying port, and the lubricant is contacted with the lower punch. As one implementation mode, the outlet end of the atomized powder tube can be communicated with two silica gel tubes, and the two silica gel tubes respectively extend into the discharge block, and the outlet end of the atomized powder tube is arranged in the powder spraying port.
Further, the atomizing injector is connected with a pressure regulating valve through an air pipe, and an electromagnetic valve is arranged on the air pipe. The pressure of lubricant sprayed out can be regulated by an electromagnetic valve and a pressure regulating valve, and the spraying equipment can be started and stopped.
Further, referring to fig. 1-2, the tablet press comprises a middle die 11, an upper fixed die 15 and a lower fixed die 16 are respectively arranged above and below the middle die 11, an upper punch 12 and a lower punch 13 are respectively fixed on the upper fixed die 15 and the lower fixed die 16, the upper fixed die 15, the lower fixed die 16 and the middle die 11 are fixed through a bracket 17, the lower fixed die 16 is driven to move by a motor, a discharging block 5 which is communicated with a spraying device through an atomization powder pipe is arranged on the middle die 11, a mixture feeding block 18 is also arranged on the middle die 11, and an air inlet channel of an air extraction device is integrated on the feeding block 18. It should be noted that: the through holes on the middle die are provided with a plurality of through holes, and the upper punch and the lower punch are respectively arranged in one-to-one correspondence with the through holes, namely, the upper punch and the lower punch are arranged above and below each through hole. The feeding block and the discharging block are directly arranged on the middle die, preferably are arranged in parallel, the feeding block and the discharging block do not move along with the middle die, and the feeding block and the discharging block are sequentially arranged above the same through hole by controlling the movement length of the middle die each time, so that the lubricant is sprayed into the through hole, the mixture is added, and the lubricant is sucked out. When the middle die moves to the position that the feeding block leaves the upper part of the through hole with the mixture, the upper punch and the lower punch which are positioned above and below the through hole move towards the inside of the through hole, so that tabletting is completed. Subsequently, the upper punch is reset and the lower punch continues to move upward until the top of the compressed tablet is outside the through hole. The movement of the upper punch and the lower punch can be realized through an air cylinder or a push rod, namely, the upper punch and the lower punch are arranged above the upper punch, and the length of each movement is set.
The middle mould, the upper fixed mould and the lower fixed mould are arranged according to actual needs, and can be strip-shaped, annular or a mixture of disc-shaped and annular. When the strip-shaped structure is formed, the middle die, the upper fixed die and the lower fixed die move in a linear manner integrally; in the case of a ring shape or a disk shape, the middle die, the upper fixed die and the lower fixed die are rotated. The whole motion process is driven by a motor, and the motor is set according to actual conditions, if: when the motor is in mixed arrangement or ring shape, the output end of the motor is fixed at the bottom center of the lower fixed mould or the top surface center of the upper fixed mould, or a circle of gear teeth is arranged on the outer ring of the lower fixed mould or the upper fixed mould, and a driving gear is arranged on the output end of the motor so as to drive the motor to rotate. When the rack is in a strip shape, the rack can be directly arranged to drive the rack to move linearly.
In the invention, the middle die, the upper fixed die and the lower fixed die are all positioned in the frame of the tablet press, so that the spraying equipment, the motor, the air extracting equipment and the feeding equipment connected with the feeding block are all arranged on the frame of the tablet press in a suitable way. For the charging device it can be understood that: the hopper of storage mixture, the bottom of hopper is provided with the filling tube, is provided with the charge pump on the filling tube, also can set up the solenoid valve, specifically selects according to actual conditions, the exit end setting of filling tube in the material feeding piece, be provided with in the material feeding piece promptly with the communicating passageway of filling tube, the bottom of material feeding piece then is the discharge gate, and the hose of air extraction equipment is placed in the material feeding piece equally, and the bottom is the air inlet, therefore realizes being in the same place with the hose of air extraction equipment and the filling tube integration of feeding equipment. Preferably, the discharge port is located at the bottom center of the charging block, and the air inlet is arranged around the discharge port, and is close to the edge of the through hole when the charging block is located above the through hole.
Further, in order to realize the up-and-down movement of the upper punch and the lower punch, the upper fixed die 15 and the lower fixed die 16 are respectively vertically provided with positioning holes 19 penetrating therethrough, the positioning holes 19 are arranged corresponding to or symmetrically with the through holes 14, and the upper punch 12 and the lower punch 13 are respectively arranged in the positioning holes 19, i.e. pass through the positioning holes and move up and down in the positioning holes 19. Meanwhile, in order to achieve automatic resetting and fixing of the upper punch and the lower punch, the bottom of the positioning hole on the upper fixed die 15 and the top of the positioning hole on the lower fixed die 16 are respectively provided with positioning rings 20, and the upper punch 12 and the lower punch 13 respectively pass through the positioning rings 20 and are fixed by springs 21. It should be noted that: and springs are sleeved on the upper punch and the lower punch, the positioning ring is arranged at the position of the through hole close to the bottom of the upper punch, one end of each spring is fixed on the top surface of the positioning ring, and the other end of each spring is fixed on the end surface of the fixing block at the top of the upper punch. Also, for the lower punch, the positioning ring is provided at a position where the through hole is close to the top surface thereof, one end of the spring is fixed to the bottom surface of the positioning ring, and the other end is fixed to the end surface of the fixing block at the bottom of the lower punch. When the upper punch and the lower punch are subjected to pressure towards the direction of the through hole, the springs are compressed, and after the force is removed, the upper punch and the lower punch can automatically reset under the action of the springs.
In using the tablet press of the present invention, referring to fig. 1, fig. 1 is a flowchart of the whole tabletting process, when the middle die 11 moves to the position where the discharging block 5 is placed above the through hole 14, lubricant is sprayed into the through hole 14 and onto the upper and lower punches, then, the middle die continues to move to the position where the feeding block is placed above the through hole sprayed with lubricant, simultaneously, the air extracting device and the feeding device are started, the mixture is added into the through hole and the lubricant is sucked out, then, the upper and lower punches are driven to move toward the inside of the through hole until tabletting is completed, the upper punch is released, the long punch is reset, the lower punch continues to move until the tablet is ejected out of the through hole, and at the same time, the tablet can be scraped from the middle die by the doctor blade 22 arranged above the middle die and collected. And finally resetting the lower punch. The process is only a tabletting process in one through hole, and along with the movement of the middle die, the spraying equipment and the feeding equipment can sequentially move on different through holes, so that the process can be continuously repeated, and continuous tabletting is further realized.
The invention is further illustrated below in conjunction with specific examples.
Examples
1. The specific proportions in parts by weight are shown in the following table 1, and the units can be mg, g, kg and the like. The preparation process was carried out as in process 2 above, wherein the magnesium stearate was 200 mesh and the spray pressure was 0.3MPa.
Table 1 proportions of the examples
| Proportioning of | Example 1 | Example 2 | Example 3 |
| Anhydrous citric acid | 1460.00 | 1460.00 | 1460.00 |
| Maltodextrin | 450.58 | 450.58 | 400.58 |
| Sorbitol | 600.00 | 550.00 | 500.00 |
| Maltitol | 550.00 | 500.00 | 500.00 |
| Vitamin B1 | 0.10 | 0.10 | 0.10 |
| Vitamin B2 | 0.10 | 0.10 | 0.10 |
| Vitamin B6 | 0.10 | 0.10 | 0.10 |
| Nicotinamide | 1.00 | 1.00 | 1.00 |
| Vitamin B12 | 0.12 | 0.12 | 0.12 |
| Vitamin C | 9.00 | 9.00 | 9.00 |
| Aspartame | 8.00 | 8.00 | 8.00 |
| Acesulfame potassium | 8.00 | 8.00 | 8.00 |
| Sodium bicarbonate | 760.00 | 860.00 | 960.00 |
| Sucralose | 14.00 | 14.00 | 14.00 |
| Pigment | 4.00 | 4.00 | 4.00 |
| Fruit powder | 5.00 | 5.00 | 5.00 |
| Essence for food | 80.00 | 80.00 | 80.00 |
| DL-malic acid | 50.00 | 50.00 | 50.00 |
2. 3 batches of effervescent tablets were prepared according to the ratios of the examples in table 1 above, with the losses of effervescent tablets from each batch being shown in table 2 below.
Table 2 production yield of effervescent tablets prepared in each example
3. The test results of the effervescent tablets prepared in the above examples are shown in Table 3 below, wherein the test results of examples 1-3 refer to the test results of 3 batches of each example, and the test results in the tables all meet the specification of GB/T29602.
Table 3 test results for each example
Meanwhile, the hardness of the prepared effervescent tablet is more than or equal to 70N through detection, wherein magnesium stearate is not detected. During tabletting, the magnesium stearate on the punch can avoid the problem of sticking and punching of the punch, and magnesium stearate is not detected in the prepared effervescent tablet, wherein the fact that magnesium stearate is not detected is not contained in the effervescent tablet, but is not contained in the effervescent tablet.
In the description of the present invention, it should be understood that the terms "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present invention, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention.
The above embodiments are only illustrative of the preferred embodiments of the present invention and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art to the technical solutions of the present invention should fall within the protection scope defined by the claims of the present invention without departing from the design spirit of the present invention.
Claims (7)
1. A rapidly disintegrating effervescent tablet composition characterized by: the coating comprises the following components in parts by weight:
35-40 parts of acidity regulator acid source, 15-25 parts of acidity regulator alkali source, 1-3 parts of food essence and pigment, 0.01-2 parts of vitamin C and vitamin B group, 25-30 parts of sweetener and 10-30 parts of food raw material.
2. A rapidly disintegrating effervescent tablet composition as claimed in claim 1, characterised in that: the acidity regulator acid source is one or more of citric acid, DL-malic acid, tartaric acid, fumaric acid, inorganic mineral acid and phosphoric acid; the acidity regulator alkali source is one or two of sodium carbonate and sodium bicarbonate; the vitamin B group is one or more of vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, biotin and nicotinamide, and the sweetener is one or more of sucralose, aspartame, acesulfame potassium, neotame, stevioside, mogroside, maltitol, sorbitol and erythritol.
3. A process for the preparation of a rapidly disintegrating effervescent tablet composition as claimed in claim 1 or 2, characterised in that: the method comprises the following steps:
(1) Mixing and granulating an acidity regulator acid source, food raw materials and food essence to obtain granules;
(2) Mixing vitamin C, vitamin B and sweetener in equal incremental manner to obtain premix;
(3) Mixing the premix, the acidity regulator alkali source and the granular material to obtain a mixed material, and tabletting by using a tablet press; before tabletting, spraying lubricant into the through holes of the middle die, the upper punch and the lower punch on the tablet press through spraying equipment, sucking the lubricant out through air extracting equipment, adding a mixture into the through holes of the middle die, and tabletting by the tablet press after the feeding is completed.
4. A method of preparing a rapidly disintegrating effervescent tablet composition as claimed in claim 3, characterised in that: the lubricant is magnesium stearate with the mesh number of 200-300 meshes and the spraying pressure of 0.2-0.6 MPa.
5. A method of preparing a rapidly disintegrating effervescent tablet composition as claimed in claim 3, characterised in that: the tablet press comprises a middle die (11), an upper fixed die (15) and a lower fixed die (16) are respectively arranged above and below the middle die (11), the upper punch (12) and the lower punch (13) are respectively fixed on the upper fixed die (15) and the lower fixed die (16), the upper fixed die (15), the lower fixed die (16) and the middle die (11) are fixed through a bracket (17), the lower fixed die (16) is driven to move through a motor, a discharging block (5) communicated with an atomization powder pipe on spraying equipment is arranged on the middle die (11), a mixture feeding block (18) is further arranged on the middle die (11), and an air inlet channel of air extraction equipment is integrated on the feeding block (18).
6. A method of preparing a rapidly disintegrating effervescent tablet composition as claimed in claim 5, characterised in that: the upper fixed mould (15) and the lower fixed mould (16) are respectively vertically penetrated with a positioning hole (19), the positioning holes (19) are correspondingly arranged with the through holes (14), and the upper punch (12) and the lower punch (13) are respectively arranged in the positioning holes (19) and move up and down in the positioning holes (19).
7. A method of preparing a rapidly disintegrating effervescent tablet composition as claimed in claim 6, characterised in that: the bottom of the locating hole on the upper fixed mould (15) and the top of the locating hole on the lower fixed mould (16) are respectively provided with a locating ring (20), and the upper punch (12) and the lower punch (13) respectively penetrate through the locating rings (20) and are fixed through springs (21).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310385940.6A CN116439378A (en) | 2023-04-07 | 2023-04-07 | Rapidly disintegrating effervescent tablet composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310385940.6A CN116439378A (en) | 2023-04-07 | 2023-04-07 | Rapidly disintegrating effervescent tablet composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116439378A true CN116439378A (en) | 2023-07-18 |
Family
ID=87119635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310385940.6A Pending CN116439378A (en) | 2023-04-07 | 2023-04-07 | Rapidly disintegrating effervescent tablet composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116439378A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207240950U (en) * | 2017-09-21 | 2018-04-17 | 山东新马制药装备有限公司 | Magnesium stearate atomizer |
| CN207416065U (en) * | 2017-09-30 | 2018-05-29 | 江西昂泰制药有限公司 | Improve the tablet tablet press machine of punch-head assembly |
| CN111631403A (en) * | 2020-07-07 | 2020-09-08 | 珠海联邦制药股份有限公司 | Vitamin C effervescent tablet and preparation method thereof |
| CN112741840A (en) * | 2020-12-28 | 2021-05-04 | 华润圣海健康科技有限公司 | B-vitamin dietary fiber effervescent tablet and preparation method thereof |
| CN115462495A (en) * | 2022-09-06 | 2022-12-13 | 江苏艾兰得营养品有限公司 | Micro effervescent tablet and preparation method thereof |
-
2023
- 2023-04-07 CN CN202310385940.6A patent/CN116439378A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207240950U (en) * | 2017-09-21 | 2018-04-17 | 山东新马制药装备有限公司 | Magnesium stearate atomizer |
| CN207416065U (en) * | 2017-09-30 | 2018-05-29 | 江西昂泰制药有限公司 | Improve the tablet tablet press machine of punch-head assembly |
| CN111631403A (en) * | 2020-07-07 | 2020-09-08 | 珠海联邦制药股份有限公司 | Vitamin C effervescent tablet and preparation method thereof |
| CN112741840A (en) * | 2020-12-28 | 2021-05-04 | 华润圣海健康科技有限公司 | B-vitamin dietary fiber effervescent tablet and preparation method thereof |
| CN115462495A (en) * | 2022-09-06 | 2022-12-13 | 江苏艾兰得营养品有限公司 | Micro effervescent tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1634908B1 (en) | Cellulose powder | |
| US9560870B2 (en) | Low calorie drink tablet | |
| CN101049121A (en) | Effervesce pieces of tea beverage, preparing method | |
| CN111631403B (en) | Vitamin C effervescent tablet and preparation method thereof | |
| CN100546571C (en) | Sangju effervescent tablet for treating common cold | |
| CN116439378A (en) | Rapidly disintegrating effervescent tablet composition and preparation method thereof | |
| US20190008761A1 (en) | Method to formulate and produce dietary supplements or functional foods in effervescent spheroidal shaped tablets | |
| CN106659225A (en) | Sugar compositions for tableting by direct compression | |
| CN107137373A (en) | A kind of Tea Polyphenols effervescent tablet and preparation method thereof | |
| CN112843010A (en) | Sitagliptin pharmaceutical composition and preparation process thereof | |
| JP2021075686A (en) | Cellulose composition, tablet, and orally disintegrating tablet | |
| CN106860475A (en) | A kind of preparation method of calcium carbonate D3 tablets | |
| CN109452522A (en) | A kind of effervescent tablet and preparation method thereof | |
| CN115462495A (en) | Micro effervescent tablet and preparation method thereof | |
| US20070003611A1 (en) | Novel method of granulating calcium carbonate and products provided therefrom | |
| CN101366461A (en) | Preparation method for salinomycin sodium fine granular formulation | |
| CN209348707U (en) | A kind of demulcen slicing device of the prepared slices of Chinese crude drugs | |
| WO2006122809A1 (en) | Filling material for a beverage container | |
| AU6351190A (en) | Magnesium carbonate and oil tableting aid | |
| CN113287709A (en) | Production process of compound vitamin effervescent tablets | |
| WO2021090422A1 (en) | Cellulose composition and tablet | |
| CN101086007B (en) | Manyzoned polypore glycopeptide production method and formulation thereof | |
| CN112791101A (en) | Multivitamin mineral tablet and preparation method thereof | |
| CN100546570C (en) | Effervescence tablet for treating wind-cold type cold | |
| CN109316459A (en) | A kind of preparation method of curcumin effervescent tablet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |