CN116421636A - Intestinal tract cleaning agent for old people and preparation method thereof - Google Patents

Intestinal tract cleaning agent for old people and preparation method thereof Download PDF

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CN116421636A
CN116421636A CN202310205005.7A CN202310205005A CN116421636A CN 116421636 A CN116421636 A CN 116421636A CN 202310205005 A CN202310205005 A CN 202310205005A CN 116421636 A CN116421636 A CN 116421636A
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lubricating
film
cleaning agent
intestinal tract
old people
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刘义豪
潘晟
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Wuhan University of Science and Engineering WUSE
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Wuhan University of Science and Engineering WUSE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention discloses an old people intestinal tract cleaning agent and a preparation method thereof, wherein the old people intestinal tract cleaning agent comprises the following raw materials in percentage by mass: 10-15% of Vaseline, 10-15% of glycerol, 3-6% of sorbitol, 20-25% of purslane juice, 10-15% of castor oil, 10-15% of emulsifying agent, 5-10% of vegetable oil, 10-15% of ethanol and the balance of purified water. Can alleviate uncomfortable sense fast to can reach good clean effect, simultaneously, prepare the product that has convenient to use function through specific mode, when can better let the patient independently use, the product can possess multiple use mode, lets the product use more convenient, can carry out corresponding implementation to different old person's intestinal and old person's living environment, can reduce the care task, use more friendly to the old man.

Description

Intestinal tract cleaning agent for old people and preparation method thereof
Technical Field
The invention relates to the technical field of old people intestinal tract cleaning, in particular to an old people intestinal tract cleaning agent and a preparation method thereof.
Background
Along with the changes of diet and lifestyle, the incidence rate of colorectal cancer in China is increasing year by year, and the current intestinal tract preparation scheme comprises oral intestinal tract cleaning drugs, cleaning enemas and the like
The old people as a special group can not understand the complicated and complicated process of intestinal tract preparation work or forget key points of intestinal tract preparation due to the factors of poor memory, poor understanding ability and the like, so that diet and medicine compliance are poor, and satisfactory intestinal tract preparation quality is difficult to achieve.
Through searching, the Chinese patent with the application number of CN110755482A discloses an intestinal tract cleaning agent and a preparation method thereof, and aims to invent the cleaning agent with small toxic and side effects, reasonable osmotic pressure and no reactions such as abdominal pain, vomiting and the like.
However, the old people are often in advanced age, the colon transmission function is weakened, a large amount of excrement is easy to remain in the intestines, the insufficient possibility of intestinal tract preparation is high, meanwhile, the intestines cannot be stimulated strongly, the action is not very convenient, a large amount of medicines are not complex to use, but a part of old people still need other people to help to use, so that whether the medicines are effective, whether the medicines are convenient to use and various factors in the intestinal tract preparation process are places needing to be considered.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides an old people intestinal tract cleaning agent and a preparation method thereof.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
according to one aspect of the present invention, an elderly intestinal cleanser is provided.
An old people intestinal tract cleaning agent comprises the following raw materials in percentage by mass:
10-15% of Vaseline, 10-15% of glycerol, 3-6% of sorbitol, 20-25% of purslane juice, 10-15% of castor oil, 10-15% of emulsifying agent, 5-10% of vegetable oil, 10-15% of ethanol and the balance of purified water.
According to another aspect of the present invention, there is also provided a method for preparing the above-mentioned intestinal cleanser for elderly people.
A method for preparing an old people intestinal tract cleaning agent, which comprises the following steps:
s1: placing glycerol, castor oil and vegetable oil into a container, fully stirring, and dividing into two parts to obtain a lubricating mixture;
s2: continuously adding a part of lubricating mixture into vaseline and ethanol until the lubricating mixture is blended into a fine-crushing state;
s3: adding an emulsifying agent into the raw materials obtained in the step S2, and preparing a lubricating shell with a hollow sleeve structure and a lubricating block with a cylindrical structure matched with the lubricating shell in a hot melting mode;
s4: adding sorbitol, purslane juice and purified water into the other part of lubricating mixture, mixing and stirring, controlling the liquid to be easily stirred and adhered to a stirring device, and obtaining a mixed liquid;
s5: sleeving the inner wall of the lubricating shell into a film, inserting a lubricating block into the inner wall of the film, and sequentially injecting mixed liquid, adding a barrier film, injecting mixed liquid and adding a film with holes at the top of the lubricating block and the inner wall of the lubricating shell to obtain a cleaning agent;
s6: and sleeving the obtained cleaning agent with a sealing film to finish the preparation of the cleaning agent.
Further, in step S5, the length of the film is the same as that of the lubrication housing, and a plurality of openings are formed in the outer wall of the film.
Further, a pull rope is arranged at the bottom end of the barrier film, penetrates through the lubricating block and extends out of the lubricating block, and a plastic soft plate matched with the lubricating block in shape is arranged on the pull rope.
Further, the barrier film and the perforated film are both connected with the film by pressure lines.
Compared with the prior art, the invention has the beneficial effects that:
can alleviate uncomfortable sense fast to can reach good clean effect, simultaneously, prepare the product that has convenient to use function through specific mode, when can better let the patient independently use, the product can possess multiple use mode, lets the product use more convenient, can carry out corresponding implementation to different old person's intestinal and old person's living environment, can reduce the care task, use more friendly to the old man.
Drawings
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, serve to explain the invention.
Fig. 1 is a schematic diagram of the preparation of the senile intestinal tract cleanser.
In the figure: 1. a lubrication housing; 2. a lubricating block; 3. a film; 4. a barrier film; 5. a perforated film; 6. a sealing film; 7. a pull rope; 8. and a plastic soft board.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments.
According to an embodiment of the present invention, there is provided an intestinal tract cleanser for the elderly.
Example 1
An old people intestinal tract cleaning agent comprises the following raw materials in percentage by mass:
10% of Vaseline, 10% of glycerol, 3% of sorbitol, 20% of purslane juice, 10% of castor oil, 10% of emulsifying agent, 5% of vegetable oil, 10% of ethanol and the balance of purified water.
Example two
An old people intestinal tract cleaning agent comprises the following raw materials in percentage by mass:
12.5% of Vaseline, 12.5% of glycerol, 4.5% of sorbitol, 22.5% of purslane juice, 12.5% of castor oil, 12.5% of emulsifying agent, 7.5% of vegetable oil, 12.5% of ethanol and the balance of purified water.
Example III
An old people intestinal tract cleaning agent comprises the following raw materials in percentage by mass:
15% of Vaseline, 15% of glycerol, 6% of sorbitol, 25% of purslane juice, 15% of castor oil, 15% of emulsifying agent, 10% of vegetable oil, 15% of ethanol and the balance of purified water.
According to another embodiment of the present invention, there is also provided a method for preparing the above-mentioned intestinal cleanser for the elderly.
As shown in fig. 1, a method for preparing an old people intestinal cleanser comprises the following steps:
s1: placing glycerol, castor oil and vegetable oil into a container, fully stirring, and dividing into two parts to obtain a lubricating mixture;
s2: continuously adding a part of lubricating mixture into vaseline and ethanol until the lubricating mixture is blended into a fine-crushing state;
s3: adding an emulsifying agent into the raw materials obtained in the step S2, and preparing a lubricating shell with a hollow sleeve structure and a lubricating block with a cylindrical structure matched with the lubricating shell in a hot melting mode;
s4: adding sorbitol, purslane juice and purified water into the other part of lubricating mixture, mixing and stirring, controlling the liquid to be easily stirred and adhered to a stirring device, and obtaining a mixed liquid;
s5: sleeving the inner wall of the lubricating shell 1 into a film 3, inserting a lubricating block 2 into the inner wall of the film 3, and sequentially injecting mixed liquid into the top of the lubricating block 2 and the inner wall of the lubricating shell 1, adding a barrier film 4, injecting mixed liquid into the mixed liquid, and adding a film 5 with holes to obtain a cleaning agent;
s6: the obtained cleaning agent is covered with a sealing film 6 to complete the preparation of the cleaning agent.
In this embodiment, in step S5, the length of the film 3 is the same as that of the lubrication casing 1, and a plurality of openings are formed in the outer wall of the film 3;
the bottom of the separation film 4 is provided with a pull rope 7, the pull rope 7 penetrates through the lubricating block 2 and extends out of the lubricating block 2, the pull rope 7 is provided with a plastic soft board 8 matched with the lubricating block 2 in shape, and the plastic soft board 8 is used for fixing and facilitating the control of the pulling of the pull rope 7.
The barrier film 4 and the perforated film 5 are connected with the film 3 by pressure lines, and the pressure lines are used for realizing that the barrier film 4 and the perforated film 5 can be separated from the film 3 by pulling.
In the specific implementation of the preparation, the length of the prepared cleaning agent can be lengthened or shortened in equal proportion according to the needs of patients.
When the device is used, a patient firstly enters a bath barrel to bath, after 5-15 minutes of bath, a medicament is taken off and a sealing film 6 is inserted into an affected part, the device is kept for about 30 seconds, a lubricant block 2 is pushed, the pushing length is controlled by a plastic soft plate 8 arranged on a pull rope, mixed liquor firstly enters an intestinal tract through the film 5 with holes, wherein the mixed liquor is partially mixed with a material of a lubricating shell 1 in the preparation and standing process, in addition, after the mixed liquor firstly enters the intestinal tract, the pressure is kept for about 10 seconds, after the mixed liquor at the top enters, a large amount of mixed liquor at the bottom can completely enter the intestinal tract by pulling the pull rope 7, after the pressure is kept for about 45-80 seconds, the lubricant block 2 is pulled out through the pull rope 7, negative pressure is generated in the process that the lubricant block 2 is separated from the shell of the lubricant block 2, so that suction force is generated, and clean dirt is discharged, and the intestinal tract is cleaned.
It should be noted that the same procedure can be performed by wetting the affected part in advance without bathing.
The further explanation is that the mixed liquid in the cleaning agent can be taken out, purified water with twice the volume of the mixed liquid is added, white sugar is added for boiling, and the mixture is filtered and drunk on an empty stomach.
For a better understanding of the technical solution of the present invention, the following description is further given with reference to examples.
Comparative example: polyethylene glycol cleaners.
Patients were prepared for colonoscopy 8, aged 65-85 years, men 4, and women 4.
Conditions are as follows: the patient fasted the first night and was administered the detergent made according to embodiments of the present invention and used in a 1 dose per person, 6 hours before the diagnostic examination the next morning.
Wherein, the first grade refers to no fecal residue in the colorectal or a small amount of clear liquid. Grade B refers to a small amount of manure or a small amount of clear liquid, but does not affect the lens entering and observation. The third grade refers to that a moderate amount of fecal sewage is intermittently arranged in each section of the intestinal tract, and each section of the colon can be observed smoothly by suction and posture change without influencing the observation result. Ding Ji it means that the intestinal tract is not clean, has a large amount of turbid fecal water or loose stool, and cannot be observed smoothly by suction or posture change.
See in particular Table 1
Figure BDA0004110594590000071
TABLE 1
According to the cleaning agent, discomfort can be quickly relieved, good cleaning effect can be achieved, meanwhile, the cleaning agent prepared by the cleaning agent can be used independently by patients, and the cleaning agent has various application modes, so that the cleaning agent is more convenient to use and more friendly to the old.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.

Claims (5)

1. The old people intestinal tract cleaning agent is characterized by comprising the following raw materials in percentage by mass:
10-15% of Vaseline, 10-15% of glycerol, 3-6% of sorbitol, 20-25% of purslane juice, 10-15% of castor oil, 10-15% of emulsifying agent, 5-10% of vegetable oil, 10-15% of ethanol and the balance of purified water.
2. A method for preparing an old people intestinal tract cleaning agent for the old people according to claim 1, characterized in that the method comprises the following steps:
s1: placing glycerol, castor oil and vegetable oil into a container, fully stirring, and dividing into two parts to obtain a lubricating mixture;
s2: continuously adding a part of lubricating mixture into vaseline and ethanol until the lubricating mixture is blended into a fine-crushing state;
s3: adding an emulsifying agent into the raw materials obtained in the step S2, and preparing a lubricating shell with a hollow sleeve structure and a lubricating block with a cylindrical structure matched with the lubricating shell in a hot melting mode;
s4: adding sorbitol, purslane juice and purified water into the other part of lubricating mixture, mixing and stirring, controlling the liquid to be easily stirred and adhered to a stirring device, and obtaining a mixed liquid;
s5: sleeving the inner wall of the lubricating shell into a film, inserting a lubricating block into the inner wall of the film, and sequentially injecting mixed liquid, adding a barrier film, injecting mixed liquid and adding a film with holes at the top of the lubricating block and the inner wall of the lubricating shell to obtain a cleaning agent;
s6: and sleeving the obtained cleaning agent with a sealing film to finish the preparation of the cleaning agent.
3. The method for preparing an elderly intestinal cleanser according to claim 2, wherein in step S5, the length of the film is the same as that of the lubricant housing, and the outer wall of the film is provided with a plurality of openings.
4. The method for preparing the senile intestinal cleanser according to claim 3, wherein a pull rope is arranged at the bottom end of the barrier film, penetrates through the lubricating block and extends out of the lubricating block, and a plastic soft plate matched with the lubricating block in shape is arranged on the pull rope.
5. The method for preparing an elderly intestinal cleanser according to claim 4, wherein the barrier film and the perforated film are connected with the film by pressure lines.
CN202310205005.7A 2023-03-01 2023-03-01 Intestinal tract cleaning agent for old people and preparation method thereof Pending CN116421636A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150085698A (en) * 2014-01-16 2015-07-24 주식회사 씨티씨바이오 Laxative composition for colon cleansing
CN111714443A (en) * 2019-03-19 2020-09-29 王向军 Anal canal lubricant and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150085698A (en) * 2014-01-16 2015-07-24 주식회사 씨티씨바이오 Laxative composition for colon cleansing
CN111714443A (en) * 2019-03-19 2020-09-29 王向军 Anal canal lubricant and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
安广文等: "肠道清洁药物的研究进展", 《山西医药杂志》, vol. 37, no. 11, pages 1015 - 1017 *
袁淑青等: "马齿苋水提物不同组分促进小鼠小肠推进活性筛选", 《中国现代中药》, vol. 19, no. 7, pages 983 - 986 *

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