CN116421285A - Embryo transfer device and system - Google Patents
Embryo transfer device and system Download PDFInfo
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- CN116421285A CN116421285A CN202210006303.9A CN202210006303A CN116421285A CN 116421285 A CN116421285 A CN 116421285A CN 202210006303 A CN202210006303 A CN 202210006303A CN 116421285 A CN116421285 A CN 116421285A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
Abstract
The present invention relates to an embryo transfer device and system, the device comprising an inner catheter assembly and an outer catheter assembly; the inner catheter assembly comprises an inner catheter and an inner catheter joint connected to the proximal end of the inner catheter, the distal end of the inner catheter is provided with a sampling part for adsorbing embryos, the end face of the sampling part is an inclined plane or an arc-shaped surface, the inner catheter assembly is provided with a second accommodating channel penetrating through the inner catheter and the inner catheter joint, and the second accommodating channel is used for providing adsorption force for the embryos or providing a conveying channel for the embryos; the outer catheter assembly includes a first receiving channel having a distal end for placement at a target location of an implant subject such that the sampling portion reaches the target location from the first receiving channel. The invention reduces the generation of embryo displacement and improves the speed of embryo suction by increasing the contact area between the sampling part of the inner catheter in the inner catheter assembly and the embryo in the embryo transfer device, thereby improving the success rate of embryo transfer.
Description
Technical Field
The invention relates to the technical field of embryo transfer, in particular to an embryo transfer device and system.
Background
In vitro fertilization-embryo transfer technology (commonly known as tube infants) is an effective means of treating refractory infertility. In general, it is divided into the following steps: ovulation promotion, egg taking, in vitro fertilization, embryo transfer and luteal support. In vitro fertilization-embryo transfer is a process in which gametes form embryos in vitro and then transfer the embryos back into the female.
Embryo transplantation serves as a key link in test-tube infants and plays a role in supporting the upward and downward movement. In performing embryo transfer, generally, the embryo is drawn through a syringe to the front end of an intrauterine tube, delivered through the inner tube of the embryo transfer tube into the cervix, and then transferred through the outer tube into the uterine cavity for implantation.
Therefore, whether or not an embryo can be sucked and smoothly implanted is an important factor affecting embryo transfer results and clinical pregnancy rate. The existing embryo transfer catheter is easy to cause embryo displacement, and is easy to cause the problems of embryo implantation failure caused by uterine contraction or bleeding when the embryo is sucked, so that the success rate of embryo transfer is reduced.
Disclosure of Invention
Based on this, there is a need to provide an embryo transfer device, which solves at least one of the aforementioned technical problems during embryo transfer, thereby improving the success rate of embryo transfer.
A first object of the present invention is to provide an embryo transfer device,
comprises an inner catheter assembly and an outer catheter assembly;
the inner catheter assembly comprises an inner catheter and an inner catheter connector connected to the proximal end of the inner catheter, the distal end of the inner catheter is provided with a sampling part for adsorbing embryos, the end face of the sampling part is an inclined surface or an arc surface, the inner catheter assembly is provided with a second accommodating channel penetrating through the inner catheter and the inner catheter connector, and the second accommodating channel is used for providing adsorption force for embryos or providing a conveying channel for embryos;
the outer catheter assembly includes a first receiving channel having a distal end for placement at a target site of an implant subject, the sampling portion being detachably connected to the first receiving channel such that the sampling portion reaches the target site from the first receiving channel.
In one implementation of the invention, the radial dimension of the sampling portion increases gradually in a direction toward the proximal end of the inner catheter.
In one implementation mode of the invention, the included angle between the end face of the sampling part and the axis of the inner catheter is 20-70 degrees.
In one implementation of the invention, the sampling portion is provided with a physical marker for indicating the orientation of the end face of the sampling portion.
In one implementation mode of the invention, the outer catheter assembly comprises a soft head tube, an outer catheter and an outer catheter connector from the distal end to the proximal end in sequence, the soft head tube and the outer catheter are integrally in a bent structure, and the first accommodating channel penetrates through the soft head tube, the outer catheter and the outer catheter connector.
In one implementation of the invention, the outer catheter comprises a main body part and a connecting part which are connected in a bending way, and the outer catheter component comprises a soft head tube, the connecting part, the main body part and an outer catheter joint from the distal end to the proximal end in sequence.
In one implementation of the invention, the bending angle of the bending structure is 10-50 degrees.
In one implementation mode of the invention, the outer catheter assembly further comprises a positioning block which is used for being abutted against the cervical proximal end of the implantation object, and the positioning block is sleeved on the outer catheter and can slide relative to the outer catheter.
In one implementation mode of the invention, the outer catheter is provided with a second positioning scale, and the positioning block is matched with the second positioning scale to indicate the length of the outer catheter entering the uterus of the implantation object; or alternatively, the process may be performed,
the positioning block is provided with a second indicating mark which is matched with the second positioning scale to indicate the length of the outer catheter entering the uterus of the implantation object.
In one implementation of the invention, the radial dimension of the positioning block is gradually increased in a direction toward the proximal end of the positioning block, and the positioning block is made of an elastomer.
In one implementation of the invention, the embryo transfer device comprises a core assembly having a hardness greater than that of the outer catheter, the distal end of the core being hemispherical, and the core assembly being detachably connectable to the first receiving channel.
In one implementation of the present invention, the inner catheter assembly further includes a support tube, the support tube being sleeved outside the inner catheter, or the support tube being connected between the inner catheter and the inner catheter adapter, the support tube having a hardness greater than that of the inner catheter.
In one implementation of the invention, a first positioning scale is provided on the support tube, the first positioning scale being used to indicate the length of the inner catheter assembly into the uterus of the implantation subject.
A second object of the present invention is to provide an embryo transfer system comprising a syringe and the embryo transfer device described above.
In one implementation of the invention, the injector and inner catheter adapter are adapted to provide suction for aspiration of embryos or thrust for delivery of embryos.
The invention improves the inner catheter assembly in the embryo transfer device, increases the contact area between the sampling part of the inner catheter in the inner catheter assembly and the embryo, reduces the generation of embryo displacement when the embryo is sucked, and improves the embryo sucking speed, thereby improving the success rate of embryo transfer.
Drawings
FIG. 1 is a schematic view of an outer catheter assembly according to the present embodiment;
FIG. 2 is a schematic view of the inner catheter assembly according to the present embodiment;
FIG. 3 is a schematic structural view of a core assembly according to the present embodiment;
FIG. 4 is a schematic view of the structure of the sampling portion of the inner catheter according to the present embodiment;
fig. 5 is a schematic view of another angle of the sampling portion of the inner catheter according to the present embodiment.
Detailed Description
In order that the above objects, features and advantages of the invention will be readily understood, a more particular description of the invention will be rendered by reference to the appended drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may be embodied in many other forms than described herein and similarly modified by those skilled in the art without departing from the spirit of the invention, whereby the invention is not limited to the specific embodiments disclosed below.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present invention, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.
As used herein, the term "proximal" refers to the end closest to the operator and distal to the end furthest from the operator, and for any individual component of the invention, the proximal and distal ends also refer to the ends of the component closest to the operator and furthest from the operator, respectively.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Any obstruction, delay, injury or micro-bleeding during passage of the embryo transfer catheter through the cervical canal may have a catastrophic effect on the embryo implantation process when the embryo transfer procedure is performed. In addition, because the physique of each person is different, the proper position of embryo transfer is also different, so that the embryo transfer catheter needs to be slowly and accurately moved to transfer the embryo to the proper position, thereby improving the clinical pregnancy rate. The existing embryo transfer catheter is easy to shift when sucking embryos, and when an outer catheter or an inner catheter is inserted into a uterine cavity, the problems of implantation failure caused by uterine contraction or bleeding and the like are easy to occur, and the existing embryo transfer catheter cannot accurately control the embryo transfer position.
To solve at least one of the above technical problems, a first aspect of the present invention provides an embryo transfer device comprising an inner catheter assembly and an outer catheter assembly, wherein the outer catheter assembly is shown in fig. 1, the inner catheter assembly is shown in fig. 2, the outer catheter assembly is used for being inserted into a uterus of an embryo implantation subject and fixing a relative position with respect to the uterus, the inner catheter assembly has an effect of accommodating the inner catheter assembly, and the inner catheter assembly is used for sucking an embryo and delivering the embryo to a target position in a uterine cavity of the embryo implantation subject through the outer catheter assembly.
Specifically, as shown in fig. 1, the outer catheter assembly includes, in order from the distal end to the proximal end, a soft head tube 101, an outer catheter 102, a positioning block 103, and an outer catheter adapter 104. The outer catheter joint 104 is connected to the proximal end of the outer catheter 102, the flexible head tube 101 is connected to the distal end of the outer catheter 102, and the flexible head tube 101 and the outer catheter 102 are integrally bent, and the flexible head tube 101 is used for being placed in the cervix of the implantation subject.
Further, the connection part of the outer catheter 102 and the soft catheter 101 avoids the bending position, so that the soft head tube 101 and the outer catheter 102 are connected, and the connection strength of the soft head tube 101 and the outer catheter 102 is higher.
Further, the positioning block 103 is sleeved on the outer catheter 102, is slidably connected to the outer catheter 102, and is used for abutting against the proximal end of the cervix of the implantation subject when the catheter assembly 1 is inserted into the body of the implantation subject, and can adjust the relative positions of the outer catheter 102 and the positioning block when the outer catheter 101 is pushed by external force.
In some embodiments, the outer catheter 102 includes a main body and a connecting portion, the outer catheter connector 104 is connected to one end of the main body, one end of the connecting portion is connected to the other end of the main body, the flexible head tube and the connecting portion are integrally arranged in a straight line in a static state, and the connecting portion and the main body are in a bent structure.
In some embodiments, the fold angle of the fold structure is between 10 ° and 50 °, which can accommodate the folded cervical morphology, increasing the strength of the outer catheter 102 and also increasing the degree of matching of the outer catheter 102 to the cervix.
The outer catheter assembly further comprises a first receiving channel extending through the flexible head tube 101, the outer catheter 102 and the outer catheter hub 104, the distal end of the first receiving channel being adapted to be disposed at a target location of the implant subject, the uterus comprising a cervix and a uterine cavity from the proximal end to the distal end, the target location being at least near the Gong Gengyuan end, the uterine cavity being adapted to be within the uterine cavity depending on the usage habits of the operator.
In some embodiments, the positioning block 103 is slidably coupled to the outer catheter 102 in order to fix the relative position of the outer catheter 102 and the uterine cavity when the outer catheter 102 is inserted into the uterine cavity. When the outer catheter is inserted into the uterine cavity, the positioning block 103 is used for abutting against the cervix, the relative position of the outer catheter 102 and the positioning block 103 is adjusted through external force, and the insertion position of the outer catheter is fixed through the fitting effect of the positioning block and the cervix.
In some embodiments, the positioning block 103 is provided with a positioning hole, the positioning block 103 is provided with elasticity, the sliding connection of the outer catheter and the positioning block can be realized under the action of external force through the elasticity of the positioning block 103 and the setting of the size of the positioning hole, the outer catheter 102 can slide relative to the positioning block 103 under the pushing action of external force, and the relative positions of the outer catheter 102 and the positioning block 103 can be fixed through the elastic action of the positioning block 103, so that the positions of the outer catheter 102 inserted into the uterine cavity can be fixed through the action of the positioning block 103 and the enemy of the cervix.
Specifically, the positioning hole penetrates the positioning block 103 to accommodate the outer catheter 102, the positioning hole is a pore canal with uniform diameter, the diameter of the positioning hole is not larger than that of the outer catheter, and the positioning block is made of elastic materials, so that the outer catheter 102 can be inserted into the positioning hole, the outer catheter 102 can slide relative to the positioning block 103 under the pushing of external force, the position of the outer catheter 102 inserted into the uterine cavity can be fixed by utilizing the elastic fixing action of the positioning block 103 and the outer catheter 102, the embryo transplanting position can be controlled more accurately, and the success rate of embryo transplanting is improved.
In some embodiments, the radial dimension of the positioning block 103 increases gradually in a direction toward the proximal end of the positioning block 103, and the positioning block is made of an elastic material.
In some embodiments, the positioning block 103 has a circular truncated cone structure, and the end of the circular truncated cone structure with the smaller outer diameter is close to the distal end of the outer catheter (i.e., the end far away from the operator), and the positioning hole penetrates through two circular surfaces of the circular truncated cone structure, so as to reduce the difficulty of the positioning block to push the cervix and combine with the cervix.
In some embodiments, the positioning block 103 is made of rubber, so that the positioning block 103 has elasticity.
In some embodiments, in order to precisely control the insertion position of the outer catheter, a second positioning scale 105 is provided on the outer catheter 102, and the positioning block cooperates with the second positioning scale 105 to indicate the length of the outer catheter 102 entering the uterus of the implantation subject; alternatively, the positioning block 103 is provided with a second indication mark, and the second indication mark cooperates with the second positioning scale 105 to indicate the length of the outer catheter 102 entering the uterus of the implantation subject.
Specifically, the outer catheter 102 is provided with a second positioning scale 105, the second positioning scale 105 is located at the distal end of the outer catheter 102, and when the outer catheter 102 is inserted into the uterus, the positioning block 103 can cover the second positioning scale 105, so that the insertion length of the outer catheter 102 is judged according to the position of the positioning block 103 covered on the positioning scale.
In some embodiments, to reduce irritation and friction to the uterine cavity, the soft-head tube 101 has a hardness of less than 95A, and to achieve this effect, the soft-head tube 101 is made of at least one of a polyurethane elastomer and a polyether block polyamide.
In some embodiments, in order to ensure the pushing force of the outer catheter, the outer catheter is inserted into the cervical as soon as possible, the hardness requirement of the outer catheter is greater than 50D, and in order to meet the requirement, the outer catheter is made of at least one of polytetrafluoroethylene, fluorinated ethylene propylene, nylon, polyethylene and polypropylene, so as to ensure the outer catheter to be inserted into the cervical quickly and smoothly, and improve the success rate of embryo transplantation.
In some embodiments, the flexible head tube 101 and the outer catheter 102 are connected by thermal welding.
As shown in fig. 2, the inner catheter assembly includes an inner catheter 201, a support tube 202, and an inner catheter adapter 203 connected to the proximal end of the inner catheter adapter. Wherein, the support tube 202 is sleeved outside the inner catheter 201, or the support tube 202 is connected between the inner catheter 201 and the inner catheter connector 203, the hardness of the support tube 202 is greater than that of the inner catheter 201, and the support tube 202 is used for providing supporting force and pushing force for the inner catheter to prevent the inner catheter 201 from bending, thereby extruding the embryo and affecting the success rate of implantation of the embryo.
As shown in fig. 3 and 4, the distal end of the inner catheter 201 has a sampling portion 204 for adsorbing an embryo, the sampling portion 204 extends from the support tube 202, the end surface of the sampling portion 204 is an inclined surface or an arc surface, the arc surface has a curvature matching with the surface of the embryo, so as to increase the contact area with the embryo, reduce the occurrence of embryo displacement, improve the success rate of embryo suction, and further improve the success rate of embryo transfer.
Further, the inner catheter assembly has a second receiving channel through the inner catheter 201 for providing an adsorption force to the embryo or for providing a delivery channel to the embryo. The inner catheter adapter 201 has a receiving cavity that is part of the second receiving channel and is used to connect a syringe so that the syringe aspirates or pushes embryos through the inner catheter 201 into the second receiving channel.
In some embodiments, to reduce damage to the embryo by the inner catheter 201 during sampling, the hardness of the sampling portion 204 is less than 95A, and to achieve this, the sampling portion 204 is made of at least one of a polyurethane elastomer and a polyether block polyamide to reduce damage to the embryo when the embryo is aspirated, while reducing friction of the embryo by the inner catheter during embryo transfer, thereby improving success rate of embryo implantation.
In some embodiments, to further avoid damage to the embryo by the sampling portion, the beveled edge is designed with an obtuse arc angle to reduce friction and damage to the embryo.
In some embodiments, the end surface of the sampling portion 204 is provided with a physical mark that cooperates with the inclined or rounded surface of the end surface to indicate the direction in which the sampling portion is sucking the embryo, thereby increasing the success rate of embryo sucking. It will be appreciated that when the embryo is sucked into the sampling portion, the embryo needs to be sucked under a microscope, and the inner catheter is generally made of transparent material, so that whether the embryo is sucked and how to suck the embryo efficiently can be ensured, for example, when the end face of the sampling portion is arranged above the embryo, the physical mark is upward, so that when an operator can observe the physical mark, the end face of the sampling portion can be determined to be downward, a larger contact area between the sampling portion and the embryo is ensured, the embryo is more easily sucked, the sampling portion is more facilitated to be in a state with the end face facing downward before the embryo is sucked, and then the embryo is more effectively prevented from being pricked by the sampling portion after the embryo is sucked, so that the probability of embryo transplantation failure caused by embryo damage is reduced. Specifically, the physical mark is an ink mark, or the physical mark is a protrusion, or may be other visual marks, and the marking mode is not limited, so long as the sucking direction of the sampling part can be correctly indicated when the embryo is sucked.
In some embodiments, the included angle between the plane of the inclined plane structure and the axis of the inner catheter 204 is 20-70 degrees, so that the contact area between the sampling part and the embryo is increased, and the success rate of embryo suction is improved.
In some embodiments, the radial dimension of the sampling portion increases gradually in a direction approaching the inner catheter hub 203 to facilitate easier access of the sampling portion into the uterine cavity.
In some embodiments, the first positioning graduation 205 is disposed on the support tube 202, and the first positioning graduation 205 is located at the proximal end of the support tube 202, so that when the inner catheter 201 is inserted into the uterine cavity through the outer catheter 102, the length of the inner catheter component entering the uterus of the implantation subject is indicated, the implantation position of the embryo after entering the uterine cavity can be controlled more accurately, the implantation accuracy of the embryo is increased, and the success rate of embryo transplantation is increased.
In some embodiments, to ensure the supporting force of the supporting tube 202, the supporting tube 202 is made of a stainless steel tube, and the stainless steel tube is provided with a third accommodating channel for accommodating the inner catheter 201, so that the supporting tube 202 protects the inner catheter 201 and prevents the inner catheter 202 from bending, thereby avoiding damage to the embryo in the first accommodating channel.
In some embodiments, the embryo transfer device further comprises a core assembly 3, the first receiving channel of the outer catheter 102 can also be used to receive the core assembly 3, the core assembly 3 being capable of providing a supporting and pushing force for the outer catheter assembly, such that for patients with cervical morphology, the outer catheter assembly can also be inserted into the cervix.
As shown in fig. 5, the core assembly 3 includes a core 301 and a core joint 302, wherein one end of the core is in a rounded hemispherical shape, and the rounded hemispherical structure facilitates the insertion of the core 301 into the outer catheter, helps the outer catheter 102 to enter the cervix more smoothly, and the end of the core 301 far from the rounded hemispherical shape is connected with the core joint 302. For patients with complicated cervical passages and even malformed cervical passages, different lining cores 301 can be selected according to the specific conditions of different patients, the lining cores 301 are placed in the first accommodating passage, and the strength and the supporting force of the outer catheter 201 are improved, so that the outer catheter 201 is easier to insert into the cervix when being pushed.
In some embodiments, in order to ensure the pushing force of the core 301, the core 301 is in a solid structure, the hardness of the core component 3 is greater than that of the outer catheter 102, specifically, the hardness of the core 301 is greater than 50D, and in order to meet this requirement, the core 301 is made of at least one of polytetrafluoroethylene, fluorinated ethylene propylene, nylon, polyethylene and polypropylene, so as to ensure that the outer catheter 201 is smoothly and quickly inserted into the cervix, and improve the accuracy of embryo transplantation.
In a second aspect the invention provides an embryo transfer system comprising a syringe and an embryo transfer device as described above, the syringe being adapted to provide suction for sucking an embryo or a pushing force for transferring an embryo, with respect to the receiving chamber of the inner catheter adapter 203.
It should be noted that the faster, smoother and as atraumatic transfer of embryos as close as possible to the pre-designed embryo implantation site is a decisive factor in achieving embryo implantation and pregnancy. The invention improves the inner catheter component and the outer catheter component, the outer catheter component adopts the soft head tube, so that the stimulation and damage to the cervix and/or the uterine cavity can be reduced when the outer catheter is inserted into the uterine cavity from the cervix, and when the embryo is sucked into the inner catheter, the inner catheter component adopts the soft sampling part, so that the embryo can be quickly sucked into the inner catheter and the damage to the embryo when the embryo is sucked is reduced, then the inner catheter carrying the embryo enters the uterine cavity from the outer catheter and is pushed to the embryo implantation position, namely, the invention realizes the implantation position of the embryo which is faster, smoother and as close as possible without wound through the combination improvement of the inner catheter component and the outer catheter component, thereby improving the success rate of embryo implantation.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The foregoing examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (15)
1. An embryo transfer device comprising an inner catheter assembly and an outer catheter assembly;
the inner catheter assembly comprises an inner catheter and an inner catheter connector connected to the proximal end of the inner catheter, the distal end of the inner catheter is provided with a sampling part for adsorbing embryos, the end face of the sampling part is an inclined surface or an arc surface, the inner catheter assembly is provided with a second accommodating channel penetrating through the inner catheter and the inner catheter connector, and the second accommodating channel is used for providing adsorption force for embryos or providing a conveying channel for embryos;
the outer catheter assembly includes a first receiving channel having a distal end for placement at a target site of an implant subject, the sampling portion being detachably connected to the first receiving channel such that the sampling portion reaches the target site from the first receiving channel.
2. The embryo transfer device of claim 1 wherein the radial dimension of the sampling portion increases progressively in a direction toward the proximal end of the inner catheter.
3. The embryo transfer device according to claim 1, wherein the end face of the sampling portion is at an angle of 20 ° to 70 ° to the axis of the inner catheter.
4. Embryo transfer device according to claim 1, wherein the sampling portion is provided with a physical marking for indicating the orientation of the end face of the sampling portion.
5. The embryo transfer device according to claim 1, wherein the outer catheter assembly comprises, in order from distal end to proximal end, a flexible head tube, an outer catheter and an outer catheter adapter, the flexible head tube being integral with the outer catheter in a bent configuration, the first receiving channel extending through the flexible head tube, the outer catheter and the outer catheter adapter.
6. The embryo transfer device according to claim 5, wherein the outer catheter comprises a main body portion and a connecting portion which are connected in a bent manner, and the outer catheter assembly comprises the flexible head tube, the connecting portion, the main body portion and the outer catheter adapter in this order from the distal end to the proximal end.
7. The embryo transfer device according to claim 5, wherein the bending structure has a bending angle of 10 ° to 50 °.
8. The embryo transfer device according to claim 1, wherein the outer catheter assembly further comprises a positioning block for abutment with the proximal end of the cervix of the implantation subject, the positioning block being sleeved on the outer catheter and being slidable relative to the outer catheter.
9. The embryo transfer device according to claim 8, wherein a second positioning scale is provided on the outer catheter, the positioning block cooperating with the second positioning scale to indicate the length of the outer catheter into the uterus of the implantation subject; or alternatively, the process may be performed,
the positioning block is provided with a second indicating mark, and the second indicating mark is matched with the second positioning scale to indicate the length of the outer catheter entering the uterus of the implantation object.
10. The embryo transfer device of claim 8 wherein the radial dimension of the positioning block increases progressively in a direction toward the proximal end of the positioning block and the positioning block is made of an elastomer.
11. The embryo transfer device of claim 1 comprising a core assembly having a hardness greater than the outer catheter, the core assembly having a hemispherical distal end and being detachably connectable to the first receiving channel.
12. The embryo transfer device of claim 1 wherein the inner catheter assembly further comprises a support tube, the support tube being sleeved outside the inner catheter or being connected between the inner catheter and the inner catheter hub, the support tube having a hardness greater than the hardness of the inner catheter.
13. The embryo transfer device of claim 12 wherein the support tube is provided with a first positioning graduation for indicating the length of the inner catheter assembly into the uterus of the implantation subject.
14. An embryo transfer system comprising a syringe and an embryo transfer device as claimed in any one of claims 1 to 13.
15. The embryo transfer system according to claim 14, wherein the syringe and the inner catheter adapter are adapted to provide suction for drawing an embryo or thrust for transferring an embryo.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210006303.9A CN116421285A (en) | 2022-01-04 | 2022-01-04 | Embryo transfer device and system |
| PCT/CN2023/070463 WO2023131190A1 (en) | 2022-01-04 | 2023-01-04 | Embryo transfer device and system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210006303.9A CN116421285A (en) | 2022-01-04 | 2022-01-04 | Embryo transfer device and system |
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| Publication Number | Publication Date |
|---|---|
| CN116421285A true CN116421285A (en) | 2023-07-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210006303.9A Pending CN116421285A (en) | 2022-01-04 | 2022-01-04 | Embryo transfer device and system |
Country Status (2)
| Country | Link |
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| CN (1) | CN116421285A (en) |
| WO (1) | WO2023131190A1 (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4642094A (en) * | 1984-05-29 | 1987-02-10 | North Jr Walter L | Non-surgical embryo transfer device |
| WO2002067772A2 (en) * | 2001-01-12 | 2002-09-06 | Napoli, Llc. | Intra-uterine devices and method of use |
| JP5623895B2 (en) * | 2010-12-15 | 2014-11-12 | 公益財団法人実験動物中央研究所 | Egg collection and embryo transfer equipment |
| US10188426B2 (en) * | 2013-02-06 | 2019-01-29 | Mark SILLENDER | Embryo transfer catheter and method |
| CN109259887B (en) * | 2018-11-01 | 2020-06-19 | 西安交通大学 | Rabbit non-operation embryo transplantation apparatus |
| CN217772475U (en) * | 2022-01-04 | 2022-11-11 | 上海市东方医院（同济大学附属东方医院） | Embryo transplanting device and system |
-
2022
- 2022-01-04 CN CN202210006303.9A patent/CN116421285A/en active Pending
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- 2023-01-04 WO PCT/CN2023/070463 patent/WO2023131190A1/en unknown
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| Publication number | Publication date |
|---|---|
| WO2023131190A1 (en) | 2023-07-13 |
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