CN116407395A - Oviduct embolism instrument and oviduct embolism system - Google Patents
Oviduct embolism instrument and oviduct embolism system Download PDFInfo
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- CN116407395A CN116407395A CN202111669293.9A CN202111669293A CN116407395A CN 116407395 A CN116407395 A CN 116407395A CN 202111669293 A CN202111669293 A CN 202111669293A CN 116407395 A CN116407395 A CN 116407395A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/20—Vas deferens occluders; Fallopian occluders
- A61F6/22—Vas deferens occluders; Fallopian occluders implantable in tubes
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- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
In the oviduct embolism apparatus and the oviduct embolism system of the invention, the apparatus comprises: the plug body is provided with a first-level morphology and a second-level morphology, and the outer side of the plug body is used for being abutted against the inner side of the oviduct; the first-order morphology comprises a columnar morphology; the second-level form is formed by changing the extending direction of the first-level form; the plug body can be stretched from the secondary form to the primary form under the action of external force, and after the external force is removed, the plug body can be restored from the primary form to the secondary form. The plug body is implanted into the oviduct from the primary form under the action of external force, and is restored to the secondary form in the oviduct after the external force is removed, the plug body in the secondary form can play a good role in anchoring and supporting the oviduct after being attached to the inner side of the oviduct, the volume of a part of the plug body actually used for plugging can be correspondingly increased, and the filling compactness of the plug body and the oviduct is improved, so that the plug effect of the oviduct plug instrument is improved.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a oviduct embolism instrument and an oviduct embolism system.
Background
In the existing oviduct embolism operation, an embolism apparatus is generally adopted to physically and mechanically perform the embolism on a oviduct, and the embolism apparatus is conveyed to the interstitial part and isthmus of the oviduct through a conveying apparatus in the operation, so as to be used as a sterilization or permanent contraception means, and in other scenes, the embolism apparatus is also used for hydrotubation embolism treatment of patients with hydrotropy before a test tube infant.
However, the existing embolic device is basically the same in the state before and after being implanted in the oviduct, which generally results in a smaller volume of the portion of the embolic device actually used for occlusion, and the embolic device has a poor anchoring effect with the oviduct and is easy to move in the oviduct, which results in a less ideal embolic effect of the embolic device on the oviduct. In addition, the existing embolic apparatus is mostly used for contraception of healthy females, and no ideal oviduct embolic measure is available at present to help patients who are prepared for tube infant surgery but have hydrotubation.
Disclosure of Invention
The invention aims to provide a oviduct embolism instrument and an oviduct embolism system, which are used for solving the problem that the existing embolism instrument has a poor embolism effect on an oviduct.
In order to solve the above technical problem, according to one aspect of the present invention, there is provided a tubal embolic device comprising: an embolic body having a primary morphology and a secondary morphology, the outer side of the embolic body being adapted to abut the inner side of the fallopian tube; the primary morphology comprises a columnar morphology; the secondary form is formed by changing the extending direction of the primary form; the plug body can be stretched from the secondary form to the primary form under the action of external force, and after the external force is removed, the plug body can be restored from the primary form to the secondary form.
Optionally, the secondary morphology comprises one or a combination of at least two of a wave morphology, a helical morphology, and a polyhedral morphology.
Optionally, the plug body includes at least one anchor segment and at least one plug segment, the anchor segment being connected to the plug segment.
Optionally, the plug body includes one section of the anchor segment and two sections of the plug segment, the anchor segment being located between two sections of the plug segment.
Optionally, when the plug body includes at least two sections of the anchoring section and at least two sections of the plug section, one section of the anchoring section is arranged between two adjacent sections of the plug section, and one section of the plug section is arranged between two adjacent sections of the anchoring section.
Optionally, when the plug body includes at least two sections of the plug segments, at least a portion of the plug segments have different radial dimensions; and/or the number of the groups of groups,
when the plug body comprises at least two sections of the anchoring segments, at least a portion of the anchoring segments have different radial dimensions.
Optionally, the oviduct embolism apparatus includes an anti-unwinding wire, the shape of the anti-unwinding wire is adapted to the second-level shape of the embolism body, and two ends of the anti-unwinding wire are respectively connected with two ends of the embolism body.
Optionally, the plug body of the primary form has an inner cavity penetrating along its own axial direction.
Optionally, the primary form of the embolic body is formed according to a spiral coil of wire.
Optionally, the primary form of the embolic body comprises a mesh structure formed by intersecting a plurality of wires and having a plurality of meshes.
Alternatively, the wire diameter of a single strand of the wire is greater than or equal to 0.0001 inches and less than or equal to 0.0070 inches.
Optionally, the primary form of the embolic body is formed according to the axial extension of the balloon itself.
Optionally, the radial dimension of the plug body of the primary form is greater than or equal to 0.01mm and less than or equal to 2mm.
Optionally, the axial dimension of the plug body of the primary form is greater than or equal to 0.1cm and less than or equal to 30cm.
Optionally, the oviduct embolic device includes a first coating applied to an outer surface of the embolic body, the first coating having water-swellable properties.
Optionally, the oviduct embolism apparatus includes a mandrel, the mandrel is disposed inside the embolism body, and the mandrel extends along an axial direction of the embolism body, and the mandrel has a property of expanding when encountering water.
Optionally, the oviduct embolic device includes a second coating, the second coating is wrapped on the outer surface of the embolic body, and the second coating includes a drug coating.
Optionally, the outer surface of the plug body is provided with a fiber structure.
Optionally, the material of the embolic body comprises a degradable material.
Based on another aspect of the present invention, the present invention also provides a oviduct embolization system, comprising:
a tubal embolic device as described above; and
and the conveying appliance is detachably connected with the oviduct embolism appliance and used for driving the oviduct embolism appliance to be implanted in an oviduct.
In summary, in the oviduct embolization apparatus and the oviduct embolization system provided by the present invention, the oviduct embolization apparatus includes: the plug body is provided with a first-level morphology and a second-level morphology, and the outer side of the plug body is used for being abutted against the inner side of the oviduct; the first-order morphology comprises a columnar morphology; the second-level form is formed by changing the extending direction of the first-level form; the plug body can be stretched from the secondary form to the primary form under the action of external force, and after the external force is removed, the plug body can be restored from the primary form to the secondary form. The first-level shape of the plug body comprises a columnar shape, namely the extending direction of the first-level shape is a linear direction, the second-level shape of the plug body is formed by changing the extending direction of the first-level shape, namely the extending direction of the second-level shape is a nonlinear direction, more degrees of freedom are provided in space, the plug body is implanted into a fallopian tube from the first-level shape under the action of external force, and is restored to the second-level shape in the fallopian tube after the external force is removed, after the plug body in the second-level shape is abutted against the inner side of the fallopian tube, the plug body can play a good anchoring and supporting role on the fallopian tube, and the volume of a part of the plug body in the second-level shape, which is actually used for plugging the fallopian tube, can be correspondingly increased, so that the filling compactness of the plug body and the fallopian tube is improved, the embolism effect of the fallopian tube embolism instrument is improved, and normal contraception of a healthy female can be helped, and a patient with hydrotropy can be helped by.
Drawings
It will be appreciated by those skilled in the art that the drawings are provided for a better understanding of the invention and do not constitute any limitation on the scope of the invention. Wherein:
FIG. 1 is a schematic illustration of a secondary aspect of a plug body according to a first embodiment of the present invention;
FIG. 2 is another schematic illustration of a secondary aspect of the embolic body of the first embodiment of the present invention;
FIG. 3 is a further schematic illustration of a secondary aspect of the plug body according to a first embodiment of the present invention;
FIG. 4 is a schematic illustration of a primary morphology of a plug body according to a second embodiment of the present invention;
FIG. 5 is a schematic illustration of a secondary aspect of a plug body according to a second embodiment of the invention;
FIG. 6 is another schematic illustration of a secondary aspect of the embolic body of the second embodiment of the present invention;
FIG. 7 is a schematic illustration of a primary morphology of a embolic body of a third embodiment of the present invention;
FIG. 8 is another schematic illustration of a primary aspect of a embolic body of a third embodiment of the present invention;
FIG. 9 is a schematic illustration of a secondary aspect of the embolic body of embodiment three of the present invention;
fig. 10 is a schematic view of a plug body according to a fourth embodiment of the present invention.
In the accompanying drawings:
10-a plug body; 11-an anchor segment; 12-embolic segment; balloon 100.
Detailed Description
The invention will be described in further detail with reference to the drawings and the specific embodiments thereof in order to make the objects, advantages and features of the invention more apparent. It should be noted that the drawings are in a very simplified form and are not drawn to scale, merely for convenience and clarity in aiding in the description of embodiments of the invention. Furthermore, the structures shown in the drawings are often part of actual structures. In particular, the drawings are shown with different emphasis instead being placed upon illustrating the various embodiments.
As used in this disclosure, the singular forms "a," "an," and "the" include plural referents, the term "or" are generally used in the sense of comprising "and/or" and the term "several" are generally used in the sense of comprising "at least one," the term "at least two" are generally used in the sense of comprising "two or more," and the term "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying any relative importance or number of features indicated. Thus, a feature defining "first," "second," "third," or "third" may explicitly or implicitly include one or at least two such features, with "one end" and "another end" and "proximal end" and "distal end" generally referring to the respective two portions, including not only the endpoints, but also the terms "mounted," "connected," "coupled," and "connected" are to be construed broadly, e.g., as being either a fixed connection, a removable connection, or as being integral therewith; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. Furthermore, as used in this disclosure, an element disposed on another element generally only refers to a connection, coupling, cooperation or transmission between two elements, and the connection, coupling, cooperation or transmission between two elements may be direct or indirect through intermediate elements, and should not be construed as indicating or implying any spatial positional relationship between the two elements, i.e., an element may be in any orientation, such as inside, outside, above, below, or on one side, of the other element unless the context clearly indicates otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
The invention provides a oviduct embolism instrument and an oviduct embolism system, which are used for solving the problem that the existing embolism instrument has a poor embolism effect on an oviduct.
The oviduct embolism apparatus of the embodiment comprises a embolism body 10 with a primary morphology and a secondary morphology, wherein the outer side of the embolism body 10 is used for being abutted against the inner side of an oviduct; the primary form comprises a columnar form, namely the extending direction of the primary form is a linear direction; the secondary shape is formed by changing the extending direction of the primary shape, which can be understood as that the extending direction of the secondary shape is a nonlinear direction, for example, an arc direction, etc., so that the plug body 10 of the secondary shape has a larger degree of freedom in space; the plug body 10 is stretchable from the secondary configuration to the primary configuration under the influence of an external force, and upon removal of the external force, the plug body 10 is recoverable from the primary configuration to the secondary configuration. The plug body 10 is implanted into the oviduct from the primary form under the action of external force, and is restored to the secondary form in the oviduct after the external force is removed, after the plug body 10 in the secondary form is attached to the inner side of the oviduct, the plug body 10 can play a good role in anchoring and supporting the oviduct, the volume of the part of the plug body 10 in the secondary form, which is actually used for plugging, can be correspondingly increased, the filling compactness of the plug body 10 and the oviduct is improved, thereby improving the plug effect of the oviduct plug instrument, further helping healthy females to perform normal contraception and helping patients with hydrotropy in the oviduct for preparing test tube infant surgery to reduce the liquid leakage rate.
In this embodiment, the secondary shape includes one or a combination of at least two of a wave shape, a spiral shape and a polyhedral shape, so that the matching effect of the embolic body 10 and the fallopian tube can be improved. The polyhedral shape may be, for example, a spherical shape, a hexahedral shape, or other three-dimensional shape. The secondary morphology can increase the dense embolic rate (dense embolic density) of the fallopian tube, enhancing the embolic effect, as understood refers to the cross-sectional effective area of the embolic body 10 and the cross-sectional area of the fallopian tube at the corresponding portion. Preferably, the secondary morphology is preferably polyhedral, which can further increase the dense embolic density. Further, taking the secondary shape as an example, the plug body 10 is first in a spiral shape outside the patient body, for example, the plug body 10 can be first in the secondary shape by a heat setting process, then stretched into a columnar shape under the action of external force, then implanted into the oviduct of the patient under the action of a delivery device, and finally the delivery device is withdrawn, so that the plug body 10 is restored from the columnar shape to the spiral shape in the oviduct.
The embolic body of the oviduct embolic device of the present invention is described in detail below with reference to the drawings, in conjunction with specific embodiments.
[ embodiment one ]
Referring to fig. 1 to 3, fig. 1 is a schematic diagram illustrating a second-level configuration of a plug body according to a first embodiment of the present invention; fig. 2 is another schematic view of the secondary aspect of the plug body according to the first embodiment of the present invention, and fig. 3 is yet another schematic view of the secondary aspect of the plug body according to the first embodiment of the present invention.
Specifically, the primary-form plug body 10 has a lumen (not shown) penetrating in the axial direction thereof, that is, the plug body 10 is generally tubular, and it is understood that the shape of the cross section of the lumen is not particularly limited in this embodiment, and may be a circular, square or irregular plane shape. Preferably, the cross-sectional shape of the lumen is the same as the profile shape of the embolic body 10, such as being circular.
Further, the primary form of the embolic body 10 is formed by a spiral coil of wire. As described above, the primary shape of the plug body 10 is substantially a spring shape or a bellows shape (hypotube), and the secondary shape may be a wave shape (shown in fig. 1), a spiral shape (shown in fig. 2), a polyhedral shape, or the like formed by using a spring shape as a single body. Of course, the secondary shape of the embolic body 10 may also be a combination of the above-listed shapes, such as the secondary shape in fig. 3, in which the spring shape is used as a single body to form a combination of a spiral shape and a polyhedral shape, i.e., the left side is a spiral shape, the right side is a polyhedral shape, the spiral shape plays a role in anchoring, and the polyhedral shape is more beneficial to self-compact tamponade after the device is delivered to the target site or compact tamponade under further extrusion by an operator using an external device (such as a guide wire), and the tamponade effect is better because the polyhedral shape has no hollow structure of the spiral shape. The combination of polymorphs is generally chosen to allow for both anchoring and dense packing. Still further, the wire diameter of a single strand of the wire is greater than or equal to 0.0001 inches and less than or equal to 0.0070 inches, where the wire diameter is understood to be the size of the wire. The material of the wire is for example a shape memory alloy.
[ example two ]
Referring to fig. 4 to 6, fig. 4 is a schematic diagram of a first-stage configuration of a plug body according to a second embodiment of the present invention, fig. 5 is a schematic diagram of a second-stage configuration of the plug body according to the second embodiment of the present invention, and fig. 6 is another schematic diagram of the second-stage configuration of the plug body according to the second embodiment of the present invention.
Specifically, the primary-form plug body 10 has a lumen (not shown) penetrating in the axial direction thereof, that is, the plug body 10 is generally tubular, and it is understood that the shape of the cross section of the lumen is not particularly limited in this embodiment, and may be a circular, square or irregular plane shape. Preferably, the cross-sectional shape of the lumen is the same as the profile shape of the embolic body 10, such as being circular.
Further, the primary form of the embolic body 10 includes a mesh structure formed by intersecting strands of wire and having a plurality of meshes, which may be one or more layers, with the understanding that the tubular embolic body is provided with a plurality of mesh structures extending through the wall of the tube. Still further, the wire has a wire diameter greater than or equal to 0.0001 inch and less than or equal to 0.0070 inch, and the wire is made of a material such as a shape memory alloy, such as nickel titanium wire. The secondary configuration of the embolic body 10 may be a combination of at least two of the secondary configurations, such as a combination of the tubular mesh configuration in a wave configuration, a spiral configuration, a polyhedral configuration, etc., as exemplified in fig. 6.
[ example III ]
Referring to fig. 7 to 9, fig. 7 is a schematic view of a first-stage configuration of a plug body according to a third embodiment of the present invention, fig. 8 is another schematic view of a first-stage configuration of a plug body according to a third embodiment of the present invention, and fig. 9 is a schematic view of a second-stage configuration of a plug body according to a third embodiment of the present invention.
The primary form of the embolic body 10 is formed by extending the balloon 100 in the axial direction thereof, and further, the primary form of the embolic body 10 may be formed by one balloon (shown in fig. 7) or a plurality of balloons 100 (shown in fig. 9), and when a plurality of balloons are provided, the plurality of balloons 100 are sequentially connected in the axial direction. As described above, the primary form of the plug body 10 is substantially ellipsoidal, and the secondary form may be a form in which the ellipsoidal is a single body, a wave form, a spiral form (shown in fig. 9), a polyhedral form, or the like. Balloon 100 is delivered into the fallopian tube in a contracted form, and then inflation medium may be added to balloon 100 to restore balloon 100 to an expanded form, thereby restoring embolic body 10 to a primary form, or directly to a secondary form. Of course, in this embodiment, the filling medium is added to the balloon 100 outside the patient's body to restore the balloon 100 to the expanded state, so that the embolic body 10 is directly restored to the secondary state, then the secondary state is restored to the primary state under the stretching of the external force, then the embolic body 10 is implanted into the fallopian tube, and after the external force is removed, the embolic body 10 formed according to the balloon 100 is restored to the secondary state again. The filling medium is, for example, contrast medium or physiological saline. Balloon 100 may be a compliant balloon 100 or a semi-compliant balloon 100.
It should be noted that, the descriptions of the first, second and third embodiments with respect to the first and second forms of the plug body may be referred to each other, and for those places where some embodiments are not described in detail, the corresponding descriptions of other embodiments may be referred to.
[ example IV ]
Referring to fig. 10, fig. 10 is a schematic diagram of a plug body according to a fourth embodiment of the present invention.
It should be noted that, the specific formation structure of the plug body 10, the form of the anchor section 11 and the form of the plug section 12 in the fourth embodiment may be referred to the description of the first embodiment, the second embodiment or the third embodiment, and the description thereof will not be repeated here.
In this embodiment, the plug body 10 includes at least one anchor segment 11 and at least one plug segment 12, and the anchor segment 11 is connected to the plug segment 12. Specifically, after the embolism body 10 is implanted into the oviduct, the anchoring section 11 is mainly anchored and attached to the thinner part of the oviduct, the embolism body 10 is fixed, the embolism section 12 is positioned on the thicker part of the oviduct, and the embolism effect is achieved, so that the oviduct can be better adapted, the embolism effect is improved, and the foreign body sensation of a patient can be reduced. Thus, after implantation of the embolic body 10 into the fallopian tube, the radial dimension of the anchor segment 11 is generally smaller than the radial dimension of the embolic segment 12 due to the restriction of the fallopian tube and the positional arrangement of the anchor segment 11 and embolic segment 12 of the embolic body, it being understood that the radial dimension herein refers to the radially largest dimension, and if the embolic body 10 is circular in cross-section, the diameter. It should be noted that, before the embolic body 10 is implanted into the fallopian tube, that is, the embolic body 10 is in a natural state without restriction of the fallopian tube, the radial dimension of the anchoring section 11 and the radial dimension of the embolic section 12 are not limited, and may be equal or unequal, or the radial dimension of the anchoring section 11 is larger than the radial dimension of the embolic section 12.
It should be noted that, the shape of the anchoring section 11 and the shape of the plug section 12 are not limited in this embodiment, for example, the two are the plug body 10 with the primary shape, or the two are the plug body 10 with the secondary shape, or one is the plug body 10 with the primary shape, and the other is the plug body 10 with the secondary shape. For example, the anchoring section 11 is in a columnar shape, and the plug section 12 is in a spiral shape; the anchoring section 11 is in a wave shape, and the plug section 11 is in a spherical shape; the anchoring section 11 is in a spiral shape, and the plug section 12 is in a hexahedral shape; any combination is possible for the person skilled in the art and is not explicitly recited here.
Further, the plug body 10 includes one section of the anchor section 11 and two sections of the plug section 12, the anchor section 11 being located between the two sections of the plug section 12. The oviduct comprises a ampulla part, an isthmus part and a interstitial part which are sequentially connected, the radial dimension of the ampulla part and the radial dimension of the interstitial part are both larger than those of the isthmus part, one section of anchoring section 11 and two sections of plug sections 12 are arranged, the anchoring section 11 can be anchored in the isthmus part to play a role in anchoring and fixing, and the two sections of plug sections 12 are respectively positioned in the ampulla part and the interstitial part to play a role in oviduct embolism. Thus, the matching effect between the embolic body 10 and the fallopian tube can be improved, the foreign body sensation of the patient can be further reduced, and the embolic body 10 can be prevented from moving to the uterus side or the ovary side in the static state or the moving state of the patient.
Preferably, when the plug body 10 includes at least two anchor segments 11 and at least two plug segments 12, one anchor segment 11 is arranged between two adjacent plug segments 12, and one plug segment 12 is arranged between two adjacent anchor segments 11. By the arrangement, on one hand, the anchoring sections 11 can be uniformly distributed, the plug sections 12 can be uniformly distributed, and on the other hand, the overall liquid leakage rate of the plug body is exponentially reduced due to the existence of a plurality of plug sections, namely, p Total (S) ＝p Bolt 1*p Bolt 2*…*p Bolt n Wherein P is Bolt n Indicating the drain rate of the nth plug segment. That is, when each plug section leaks, the plug section can not be totally disabled. For patients with hydrotubal disease, the weeping rate of the hydrotubation can be further reduced.
It should be appreciated that where the plug body 10 includes at least two segments 12, at least a portion of the segments 12 may vary in radial dimension. Similarly, when the plug body 10 includes at least two of the anchor segments 11, at least a portion of the anchor segments 11 may have different radial dimensions.
[ example five ]
It should be noted that, as the preferred embodiment describing the oviduct embolism apparatus, the fifth embodiment focuses on describing the preferred scheme of the oviduct embolism apparatus based on the embolism body, and the description of the structure of the embolism body may be referred to the description of the first embodiment, the second embodiment, the third embodiment and the fourth embodiment, and the description will not be repeated here.
In this embodiment, the radial dimension of the plug body 10 in the primary form is greater than or equal to 0.01mm and less than or equal to 2mm; the axial dimension (length) of the plug body 10 of the primary form is 0.1cm or more and 30cm or less. In a practical scenario, an operator can configure the embolic body 10 with proper radial dimension and axial dimension according to the condition of the oviduct of the patient so as to be matched with the oviduct of the patient to the greatest extent, so that foreign body sensation of the patient is avoided as far as possible after the embolic body 10 is implanted into the oviduct of the patient, and in addition, the embolic body 10 with proper axial dimension is selected, so that the situation that effective embolism cannot be carried out due to the fact that the embolic body 10 is short in dimension, and the situation that the ampulla or even the ovary possibly falls into the oviduct due to the fact that the embolic body is too long in dimension is avoided.
Preferably, the oviduct embolism apparatus comprises an anti-unwinding wire, the shape of the anti-unwinding wire is adapted to the secondary shape of the embolism body 10, and two ends of the anti-unwinding wire are respectively connected with two ends of the embolism body 10. The provision of the anti-rotation wire can limit the extensibility (axial extensibility) of the embolic body 10, avoiding the secondary morphology of the embolic body 10 from being released due to external pressure after implantation into the fallopian tube. For example, when the plug body 10 is spirally wound according to a wire to form a spring shape, the anti-unwinding wire can prevent the spring-shaped plug body 10 from being elongated and unwound. The anti-unwinding wire can be, for example, an elastic polymer material or a surgical suture.
Preferably, the tubal embolic device comprises a first coating applied to the outer surface of the embolic body 10, the first coating having water-swellable properties. After the plug body 10 is implanted into the oviduct, the first coating can expand when meeting water, so that gaps between the plug body 10 and the inner side of the oviduct are filled, and the filling compactness is improved. The first coating may be, for example, a gel coating.
Preferably, the oviduct embolization device comprises a mandrel, the mandrel is arranged inside the embolization body 10, and the mandrel extends along the axial direction of the embolization body 10, and the mandrel has the property of swelling when meeting water. After the plug body 10 is implanted into the oviduct, the mandrel expands when meeting water, so that the plug body 10 is driven to expand, the outer side of the plug body 10 is tightly attached to the inner side of the oviduct, and the filling compactness is improved.
Optionally, the oviduct embolism apparatus of the embodiment can be combined with gel, and after the oviduct embolism apparatus is implanted into an oviduct, a proper amount of gel can be injected from an oviduct port to achieve the effect of complete occlusion.
Optionally, the oviduct embolic device includes a second coating that coats the outer surface of the embolic body 10, the second coating including a drug coating. The drug coating can improve the biocompatibility of the oviduct embolism apparatus, inhibit the endothelial cell proliferation of the oviduct and inhibit inflammation. For healthy women, the drug coating may be coated with a slow release spermicidal drug for the contraceptive needs of healthy women.
Preferably, the outer surface of the plug body 10 is provided with a fibrous structure, such as a fibrous fleece. The fiber villus is attached to the outer surface of the embolism body 10, so that the compatibility with the inner wall of the oviduct can be increased, and the periphery of the embolism body 10 can generate aseptic inflammation after a period of operation, thereby further enhancing the embolism effect with the oviduct.
Preferably, the material of the embolic body 10 comprises a degradable material, in particular a biodegradable material, such as polylactic acid, polyhydroxyacids and polypeptides, polyglycolic acid [ poly (glycolic acid), PGA ], polycaprolactone (PCL), polyethers, polycarbonates, etc. The embolic body 10 made of degradable materials can be dissolved in the human body after being used for a period of time and can be absorbed by the human body, so that injury and discomfort to a patient in the process of taking the embolic body 10 out of the oviduct are avoided.
Based on the oviduct embolism instrument, the invention also provides an oviduct embolism system which comprises the oviduct embolism instrument and a conveying instrument, wherein the conveying instrument is detachably connected with the oviduct embolism instrument and used for driving the oviduct embolism instrument to be implanted in an oviduct. The present embodiment is not limited to the specific structure of the delivery device, and those skilled in the art can preferably configure the device according to the prior art. For example, the conveying appliance and the oviduct embolism appliance are connected through a release structure, the release structure can be a mechanical release structure, a hydrolysis release structure or an electrolysis release structure, and the conveying appliance and the oviduct embolism appliance can be conveniently separated from each other under the condition that the implantation effect of the oviduct embolism appliance in an oviduct is ideal. In addition, under the condition that the implantation effect of the oviduct embolism apparatus in the oviduct is poor, the conveying apparatus can also temporarily recover the oviduct embolism apparatus into an internal sheath tube, and then re-implant and release the oviduct embolism apparatus.
In summary, in the oviduct embolization apparatus and the oviduct embolization system provided by the present invention, the oviduct embolization apparatus includes: a plug body 10 having a primary form and a secondary form, the outside of the plug body 10 being adapted to abut against the inside of the fallopian tube; the first-order morphology comprises a columnar morphology; the second-level form is formed by changing the extending direction of the first-level form; the embolic body 10 is stretchable from the secondary configuration to the primary configuration under the influence of an external force, and upon removal of the external force, the embolic body 10 is recoverable from the primary configuration to the secondary configuration. The above configuration shows that the primary form of the plug body 10 comprises a columnar form, namely, the extending direction of the primary form is a linear direction, the secondary form of the plug body 10 is formed by changing the extending direction of the primary form, namely, the extending direction of the secondary form is a nonlinear direction, more degrees of freedom are provided in space, the plug body 10 is implanted into a fallopian tube from the primary form under the action of external force, and is restored to the secondary form in the fallopian tube after the external force is removed, after the plug body 10 in the secondary form is abutted against the inner side of the fallopian tube, the plug body 10 can play a good anchoring and supporting role on the fallopian tube, and the volume of the part of the plug body 10 in the secondary form, which is actually used for plugging, can be correspondingly increased, so that the filling compactness of the plug body 10 and the fallopian tube is improved, the plug effect of the fallopian tube plug instrument is improved, and healthy female normal contraception can be helped, and a patient with fallopian tube hydrops can be helped by the test tube infant operation.
The foregoing description is only illustrative of the preferred embodiments of the present invention, and is not intended to limit the scope of the present invention in any way, and any changes and modifications made by those skilled in the art in light of the foregoing disclosure will be deemed to fall within the scope and spirit of the present invention.
Claims (20)
1. A tubal embolic device, comprising: an embolic body having a primary morphology and a secondary morphology, the outer side of the embolic body being adapted to abut the inner side of the fallopian tube; the primary morphology comprises a columnar morphology; the secondary form is formed by changing the extending direction of the primary form; the plug body can be stretched from the secondary form to the primary form under the action of external force, and after the external force is removed, the plug body can be restored from the primary form to the secondary form.
2. The oviduct embolic instrument of claim 1, wherein the secondary morphology comprises one or a combination of at least two of a wavy morphology, a helical morphology, and a polyhedral morphology.
3. The oviduct embolic instrument of claim 1, wherein the embolic body comprises at least one anchor segment and at least one embolic segment, the anchor segment being connected to the embolic segment.
4. A oviduct embolic instrument as in claim 3, wherein the embolic body comprises one section of the anchor segment and two sections of the embolic segment, the anchor segment being located between two sections of the embolic segment.
5. A oviduct embolization device according to claim 3, wherein when the embolization body comprises at least two sections of the anchoring section and at least two sections of the embolization section, one section of the anchoring section is arranged between two adjacent sections of the embolization section, and one section of the embolization section is arranged between two adjacent sections of the anchoring section.
6. The oviduct embolic instrument of claim 3, 4 or 5, wherein when said embolic body comprises at least two segments of said embolic segments, at least a portion of said embolic segments vary in radial dimension; and/or the number of the groups of groups,
when the plug body comprises at least two sections of the anchoring segments, at least a portion of the anchoring segments have different radial dimensions.
7. The oviduct embolic instrument of claim 1, wherein the oviduct embolic instrument comprises an anti-unwinding wire having a morphology compatible with the secondary morphology of the embolic body, the two ends of the anti-unwinding wire being connected to the two ends of the embolic body, respectively.
8. The oviduct embolic instrument of claim 1, wherein said primary embolic body has a lumen therethrough in an axial direction thereof.
9. The oviduct embolic device of claim 8, wherein the primary morphology of the embolic body is formed according to a spiral coil of wire.
10. The oviduct embolic instrument of claim 8, wherein the primary morphology of the embolic body comprises a mesh structure having a plurality of meshes formed by a plurality of intersecting strands of wire.
11. The oviduct embolic device of claim 9 or 10, wherein the wire diameter of a single strand of said wire is greater than or equal to 0.0001 inches and less than or equal to 0.0070 inches.
12. The oviduct embolic instrument of claim 1, wherein the primary morphology of the embolic body is formed according to the axial extension of the balloon itself.
13. The oviduct embolic device of claim 1, wherein the radial dimension of the primary embolic body is greater than or equal to 0.01mm and less than or equal to 2mm.
14. The oviduct embolic device of claim 1, wherein the primary embolic body has an axial dimension greater than or equal to 0.1cm and less than or equal to 30cm.
15. The oviduct embolic device of claim 1, wherein the oviduct embolic device comprises a first coating applied to an outer surface of the embolic body, the first coating having water-swellable properties.
16. The oviduct embolic instrument of claim 1, wherein the oviduct embolic instrument comprises a mandrel disposed inside the embolic body, and the mandrel extends axially of the embolic body, the mandrel having water-swellable properties.
17. The oviduct embolic device of claim 1, wherein the oviduct embolic device comprises a second coating, the second coating the outer surface of the embolic body, the second coating comprising a drug coating.
18. The oviduct embolic instrument of claim 1, wherein the outer surface of the embolic body is provided with a fibrous structure.
19. The oviduct embolic device of claim 1, wherein the material of the embolic body comprises a degradable material.
20. A tubal embolization system, comprising:
a oviduct embolic instrument as in any of claims 1-19; and
and the conveying appliance is detachably connected with the oviduct embolism appliance and used for driving the oviduct embolism appliance to be implanted in an oviduct.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111669293.9A CN116407395A (en) | 2021-12-30 | 2021-12-30 | Oviduct embolism instrument and oviduct embolism system |
| CN202310749570.XA CN116712245A (en) | 2021-12-30 | 2021-12-30 | Oviduct embolism instrument and oviduct embolism system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111669293.9A CN116407395A (en) | 2021-12-30 | 2021-12-30 | Oviduct embolism instrument and oviduct embolism system |
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| CN202310749570.XA Division CN116712245A (en) | 2021-12-30 | 2021-12-30 | Oviduct embolism instrument and oviduct embolism system |
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| CN116407395A true CN116407395A (en) | 2023-07-11 |
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| CN202111669293.9A Pending CN116407395A (en) | 2021-12-30 | 2021-12-30 | Oviduct embolism instrument and oviduct embolism system |
| CN202310749570.XA Pending CN116712245A (en) | 2021-12-30 | 2021-12-30 | Oviduct embolism instrument and oviduct embolism system |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310749570.XA Pending CN116712245A (en) | 2021-12-30 | 2021-12-30 | Oviduct embolism instrument and oviduct embolism system |
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| CN (2) | CN116407395A (en) |
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- 2021-12-30 CN CN202111669293.9A patent/CN116407395A/en active Pending
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