CN116406669A

CN116406669A - Weeding combination

Info

Publication number: CN116406669A
Application number: CN202310016425.0A
Authority: CN
Inventors: 加德夫·拉耶尼肯特·施洛夫; 维克拉姆·拉耶尼肯特·施洛夫; 加内什·斯里尼瓦沙·拉奥
Original assignee: UPL Ltd
Current assignee: UPL Ltd
Priority date: 2018-08-23
Filing date: 2019-08-21
Publication date: 2023-07-11
Also published as: AR116012A1; WO2020039366A1; CN113056198A; BR112021003218A2

Abstract

The present invention relates to herbicidal combinations. The herbicidal combination comprises at least one acetyl-coa carboxylase inhibitor, at least one photosynthesis II inhibitor and at least one microtubule assembly inhibitor. The invention also relates to a method of controlling weeds at a locus using the herbicidal combination described above, and to a kit of parts comprising the various components of the herbicidal combination. The herbicidal combination of the present invention exhibits excellent synergistic control. The combination provides for the control of weeds both pre-emergence and post-emergence, providing a broader spectrum of control that aids in resistance management, thereby preventing weeds from being resistant to either herbicide, while providing a broader spectrum of control at lower rates of use.

Description

Weeding combination

The application is a divisional application of International application PCT/IB2019/057044, which enters China national stage at 2021, 4 and 9 days, with application number 201980066745.9 and the name of weeding combination.

Technical Field

The present invention relates to combinations of herbicides for controlling harmful undesired plants. The present invention more particularly relates to synergistic combinations of herbicides.

Background

Weeds are undesirable plants that can severely impair crop yield. Farmers usually control these plants at a pre-planting stage and after sowing. Modern herbicides are used to control or suppress these undesirable vegetation, thereby allowing the sown crop to gain more nutrition.

Current practice includes combining herbicides with different modes of action, which allows for a broader spectrum of control and resistance management. However, the presently known combinations are not sufficient to control resistant weeds and persistent weeds. Growers are increasingly faced with complex weed conditions that cannot be controlled with only one herbicide.

Herbicides that act as inhibitors of acetyl-coa carboxylase (ACCase) are known to control undesirable vegetation such as grasses (grasses). ACCase inhibitors were first introduced in 1978 and are widely used to control grass species. ACCase inhibitors exist in three chemical groups: aryloxy-phenoxypropionic Acid (APP), cyclohexanedione (CHD) and phenylpyrazoline (PPZ). APP is an important class of herbicides because of their high efficiency, broad spectrum, low toxicity and good selectivity. Some known APP herbicides are clodinafop-propargyl, cyhalofop-butyl, methyl-p-butyl ethyl fenoxaprop-p-ethyl, butyl fluazifop-p-butyl, butyl fluazifop-p-butyl fluazifop-p-butyl, quizalofop-p-ethyl, oxifen, quizalofop-ethyl and clomazone.

APP herbicides (such as clodinafop-propargyl) are used as post-emergence herbicides (gramineae herbicides). The clodinafop-propargyl is 2-propynyl- (2R) -2- [4- [ (5-chloro-3-fluoro-2-pyridinyl) oxy ] phenoxy ] propionate, which is an ester of 2- (4- (3-chloro-5-fluoro-2-pyridinyl) phenoxy-propionic acid, which is a systemic herbicide acting on post-emergence weeds such as wild oat, prairie bluegrass, green bristlegrass, barnyard grass, bosryegrass and volunteer canary grass seeds.

Microtubule inhibitors are commonly used to control some broadleaf weeds in annual grasses, several crops and turfgrass. These herbicides are taken up by both roots and shoots, causing cell damage, and are excellent tools for controlling pre-emergence weeds. Pendimethalin is a microtubule inhibitor herbicide that is used pre-emergence and post-emergence for control of broadleaf and annual grasses. Pendimethalin is known to be useful in combination, such as those known from WO2012177860 (Mann et al), which is incorporated herein by reference in its entirety.

Photosynthesis inhibitors control many broadleaf and some herbaceous weeds by interfering with the electron transport chain and indirect mulch film leakage and cell damage. These herbicides are excellent tools for controlling pre-emergence weeds. Sedrin is a photosynthesis inhibitor herbicide used for pre-emergence and post-emergence control of broadleaf and annual grasses. It is known that metribuzin can be combined with other herbicides, such as the combination known from WO2011082958 (Hubert et al), which is incorporated herein by reference in its entirety.

Combinations of herbicides are used to control a wider range of weeds. However, combinations of herbicides may not always produce the desired effect. Combinations of herbicides can result in additive or antagonistic effects. It can also cause phytotoxicity to crops, making it an undesirable combination. Thus, the farmer must carefully select herbicides that can be combined to provide a synergistic effect that will control weeds while not having a phytotoxic effect on the crop and reduce the chance of producing herbicide resistant weeds.

There is therefore a need in the art for combinations with advantageous properties, such as synergistic, herbicidal combinations that aid in resistance management, reduce the dosage of herbicide used and thus cause minimal environmental damage, herbicidal combinations with excellent residual effects.

Accordingly, embodiments of the present invention may ameliorate one or more of the above problems:

disclosure of Invention

Thus, in one aspect, the invention may provide a herbicidal combination comprising:

(a) At least one acetyl-coa carboxylase inhibitor selected from the group consisting of an arylphenoxy propionate herbicide, a cyclohexanedione herbicide, or a phenylpyrazoline herbicide;

(b) At least one photosynthesis II inhibitor selected from the group consisting of triazine herbicides, triazone herbicides, triazole herbicides, triazolone herbicides, uracil herbicides, pyridazinone herbicides, triazolopyrimidine herbicides, or phenylcarbamate herbicides;

(c) At least one microtubule assembly inhibitor herbicide selected from the group consisting of dinitroaniline herbicides, phosphoramidate herbicides, pyridine herbicides, benzamide herbicides, or benzoic acid herbicides.

In another aspect, the present invention may provide a herbicidal combination comprising:

(a) At least one of the first herbicides is selected from the group consisting of, selected from the group consisting of clodinafop-propargyl, cyhalofop-butyl, belate, methyl belate, ethyl oxaprozin, ethyl, and ethyl fenoxaprop-p-ethyl, ethyl fenoxaprop-p-ethyl, fluazifop-p-butyl, butyl fluazifop-p-butyl butyl fluazifop-p-butyl, haloxyfop-methyl, quizalofop-p-ethyl, ethyl quizalofop-p-ethyl, and clomazone or agriculturally acceptable salts;

(b) At least one second herbicide selected from the group consisting of triazine herbicides, triazone herbicides, triazole herbicides, triazolone herbicides, or triazolopyrimidine herbicides; and

(c) At least one third herbicide selected from dinitroaniline herbicides.

Thus, in one aspect, the invention may provide a method of controlling weeds at a locus, the method comprising applying to the locus a herbicidal combination comprising:

Another aspect of the invention may provide a method of controlling weeds at a locus, the method comprising applying to the locus a combination comprising:

(a) At least one of the first herbicides is selected from the group consisting of, it is selected from the group consisting of fluazinam, clodinafop-propargyl, cyhalofop-butyl, quizalofop-butyl, methyl, ethyl oxazalofop-butyl, fenoxaprop-p-ethyl, ethyl oxazalofop-ethyl, haloxyfop-butyl, butyl fluhaloxyfop-butyl, haloxyfop-butyl, quizalofop-ethyl, ethyl quizalofop-ethyl and sugar grass or an agriculturally acceptable salt;

(c) At least one third herbicide selected from dinitroaniline herbicides.

In one aspect, the present invention may provide a herbicidal composition comprising:

Another aspect of the invention may provide a composition comprising:

(c) At least one third herbicide selected from dinitroaniline herbicides.

Yet another aspect of the invention may provide a method of increasing crop yield by applying a combination comprising:

Another aspect of the invention may provide a method of improving plant health, the method comprising applying a combination at a locus of a plant, the combination comprising:

Detailed Description

The term herbicide as used herein shall mean an active ingredient that kills, controls, or otherwise adversely alters plant growth. As used herein, a herbicidally effective or vegetation controlling amount is an amount of active ingredient that causes a "herbicidal effect," i.e., an effect that is adversely altered and includes deviations from natural development, killing, regulation, desiccation, retardation. The terms "plant" and "vegetation" include, but are not limited to, germinated seeds, germinated seedlings, plants germinated from vegetative propagules, and grown vegetation. As used herein, the term "locus" shall mean the vicinity of a desired crop where weed control (typically selective weed control) of the desired weed is desired. Sites include the vicinity of desired crop plants where weed infestation has occurred or has not occurred. The term crop shall include a large number of desired crop plants or individual crop plants grown at a locus.

In any aspect or embodiment described below, the phrase "comprising" may be replaced with the phrase "consisting of …" or "consisting essentially of …" or "consisting essentially of …". In these aspects or embodiments, the combination or composition comprises or consists essentially of the specific components listed therein, to the exclusion of other fungicides or insecticides or herbicides or plant growth promoters or adjuvants or excipients not specifically listed therein.

Surprisingly, the inventors have found that a combination of an acetyl-coa carboxylase inhibitor, a microtubule inhibitor and a photosystem II inhibitor can lead to synergistic control of undesired plants at the locus of the plant.

(b) At least one photosynthesis II inhibitor selected from the group consisting of triazine herbicides, triazone herbicides, triazole herbicides, triazolone herbicides, uracil herbicides, pyridazinone herbicides, triazolopyrimidine herbicides, or phenylcarbamate herbicides; and

In one embodiment, the herbicidal combination of the present invention comprises one herbicide from these three classes of herbicides.

(a) An acetyl-coa carboxylase inhibitor selected from an arylphenoxy propionate herbicide, a cyclohexanedione herbicide, or a phenylpyrazoline herbicide;

(b) A photosystem II inhibitor selected from a triazine herbicide, a triazone herbicide, a triazole herbicide, a triazolone herbicide, a uracil herbicide, a pyridazinone herbicide, a triazolopyrimidine herbicide, or a phenyl carbamate herbicide; and

(c) Microtubule assembly inhibitor herbicides selected from dinitroaniline herbicides, phosphoramidate herbicides, pyridine herbicides, benzamide herbicides or benzoic acid herbicides;

in another aspect, the invention provides a method of controlling weeds at a locus by applying the combination of the invention to the locus.

Thus, in this aspect, the invention can provide a method of controlling weeds at a locus, said method comprising applying to the locus a combination comprising:

In another aspect, the invention provides a composition comprising a combination of the invention, and at least one other agrochemically acceptable excipient.

Thus, in this aspect, the invention may provide a composition comprising:

In another aspect, the invention provides a method of increasing crop yield by using the combination of the invention.

Thus, in this aspect, the invention may provide a method of increasing crop yield by applying a combination comprising:

In another aspect, the invention may provide methods of improving plant health using the combinations of the invention.

Thus, in this aspect, the invention may provide a method of improving plant health, the method comprising applying at the locus of a plant a combination comprising:

Each of the above aspects may have one or more embodiments.

Each of the embodiments described below may be applicable to one or all of the aspects described above. These embodiments are intended to be read as being preferred features of one or all of the aspects described above. Each of the embodiments described below applies individually to each of the aspects described above.

In one embodiment, the acetyl-coa carboxylase inhibitor is an arylphenoxy propionate herbicide.

In one embodiment, the arylphenoxy propionate herbicide is selected from the group consisting of trifloxystrobin, clodinafop-propargyl, cyhalofop-butyl, haloxyfop-butyl, methyl, ethyl, and sugar grass esters or agriculturally acceptable salts thereof.

In one embodiment, the arylphenoxy propionate herbicide is fluazinam or clodinafop-propargyl.

In one embodiment, the arylphenoxy propionate herbicide is haloxyfop, or haloxyfop.

In one embodiment, the arylphenoxy propionate herbicide is quizalofop, ethyl quizalofop, quizalofop-p-ethyl, ethyl quizalofop-ethyl, or clomazone.

In one embodiment, the acetyl-coa carboxylase inhibitor is a cyclohexanedione herbicide.

In one embodiment, the cyclohexanedione herbicide is selected from the group consisting of fenquinetrione, ketospiradox, lancotrione, mesotrione, sulcotrione, terfuraltrione, and cyclosulfamide.

In one embodiment, the cyclohexanedione herbicide is mesotrione.

In one embodiment, the cyclohexanedione herbicide is sulcotrione.

In one embodiment, the cyclohexanedione herbicide is cyclosulfamide.

In one embodiment, the acetyl-coa carboxylase inhibitor is a phenylpyrazoline herbicide.

In one embodiment, the phenylpyrazole herbicide is selected from the group consisting of iprovalicarb, flumioxazin, pinoxaden, and pyriftalid.

In one embodiment, the phenylpyrazole herbicide is pinoxaden.

In one aspect, the combination comprises a photosynthesis II inhibitor.

In one embodiment, the photosynthesis II inhibitor is selected from a triazine herbicide, a triazinone herbicide, a triazolone herbicide, a uracil herbicide, a pyridazinone herbicide, a triazolopyrimidine herbicide, or a phenylcarbamate herbicide.

In one embodiment, the inhibitor of photosynthesis II is a triazine herbicide.

In one embodiment, the triazine herbicide is selected from the group consisting of promethazine, furin, triamcinolone, atrazine, colazine, cyanazine, ciprofezin, liquorice, imazalil, atrazine, ciprofezin, aspoxicam, promazine, terbuthylazine, indac, triazophos, atrazine, ether grass, plodin, amiloride, amitraz, simaron, terbutamid, amethodim, amethode, amethodin, prometryn, simetryn, and terbutryn.

In one embodiment, the triazine herbicide is atrazine.

In one embodiment, the inhibitor of photosynthesis II is a triazinone herbicide.

In one embodiment, the triazinone herbicide is selected from the group consisting of tertrazinone, terbutryn, buprofezin, metamitron, metribuzin, and trifluoperazin.

In one embodiment, the triazinone herbicide may be selected from the group consisting of hexazinone, metamitron and metribuzin.

In one embodiment, the triazinone herbicide is a hexazinone.

In one embodiment, the triazinone herbicide is metamitron.

In one embodiment, the triazinone herbicide is metribuzin.

In one embodiment, the inhibitor of photosynthesis II is a triazole herbicide.

In one embodiment, the triazole herbicide is selected from the group consisting of clomazone, fenbuconazole, triazophos and flumetsulam.

In one embodiment, the triazolone herbicide is selected from the group consisting of amicarbazone, cereal herbicides, carfentrazone-ethyl, flucarbazone-sodium, triazoxamide, prosulfuron, sulfentrazone-ethyl and thifenuron (thiocarbazone).

In one embodiment, the triazolone herbicide is selected from the group consisting of carfentrazone-ethyl, trifloxysulfuron and sulfentrazone.

In one embodiment, the triazolone herbicide is sulfenamide.

In one embodiment, the inhibitor of photosynthesis II is a triazolopyrimidine herbicide.

In one embodiment, the triazolopyrimidine herbicide is selected from the group consisting of clofentezine, diclosulam, florasulam, flumetsulam, sulfentrazone, penoxsulam, and sulfentrazone.

In one embodiment, the triazolopyrimidine herbicide is penoxsulam.

In one embodiment, the inhibitor of photosynthesis II is a uracil herbicide.

In one embodiment, the uracil herbicide is selected from the group consisting of bupirimate, triclopyr, flumioxazin, fluoxastrobin (fluaropacil), clomazone, cyprodinil, saflufenacil, terfenacil, or flumetsulam.

In one embodiment, the uracil herbicide is saflufenacil.

In one embodiment, the inhibitor of photosynthesis II is a pyridazinone herbicide.

In one embodiment of the present invention, in one embodiment, the pyridazinone herbicide is selected from chlorpyrifos chlorpyrifos, dichlord Mi Dasong, fluidazine dimidazov, pyridate, bentazone or bidenda.

In one embodiment, the photosystem II inhibitor is a phenylcarbamate herbicide.

In one embodiment, the phenylcarbamate herbicide is betalain.

In one embodiment, the phenylcarbamate herbicide is bendiuron.

In one aspect, the combination of the invention comprises at least one microtubule assembly inhibitor.

In one embodiment, the microtubule assembly inhibitor herbicide is selected from the group consisting of a dinitroaniline herbicide, a phosphoramidate herbicide, a pyridine herbicide, a benzamide herbicide, or a benzoic acid herbicide.

In one embodiment, the microtubule assembly inhibitor is a dinitroaniline herbicide.

In one embodiment, the dinitroaniline herbicide may be selected from the group consisting of flumetsulam, bufalin, clomazone, trifluralin, dilemma, ethambutol, triamcinolone, isopropaline, sulfenamide, pendimethalin, aminopropouline, ciprofloxacin, and trifluralin.

In one embodiment, the dinitroaniline herbicide may be selected from the group consisting of pendimethalin and pendimethalin.

In one embodiment, the microtubule assembly inhibitor is a phosphoramidate herbicide.

In one embodiment, the phosphoramidate herbicide is selected from the group consisting of methamphetamine or imazalil.

In one embodiment, the microtubule assembly inhibitor is a pyridine herbicide.

In one embodiment, the pyridine herbicide is selected from the group consisting of amiloride, iolopyr, clopyralid, diflufenican, dithiopyr, florpyr-azaxifen, fluroxypyr, haloxyfop-butyl, picloram, flupirfenidone, clomazone (pyribenzoxim), methoxamine, thiabendazole, and triclopyr.

In one embodiment, the pyridine herbicide is diflufenican.

In one embodiment, the pyridine herbicide is fluroxypyr.

In one embodiment, the pyridine herbicide is a fluroxypyr-meptyl ester.

In one embodiment, the pyridine herbicide is picloram.

In one embodiment, the pyridine herbicide is sulfenamide.

In one embodiment, the microtubule assembly inhibitor is a benzamide herbicide.

In one embodiment, the benzamide herbicide is selected from the group consisting of propyzamide or clomazone.

In one embodiment, the microtubule assembly inhibitor is a benzoic acid herbicide.

In one embodiment, the benzoic acid herbicide is selected from the group consisting of clomazone, oxadiazon, dicamba, 2,3,6-TBA, dicamba, bispyribac, pyripyropene (pyriminobac), or pyriminobac-methyl.

In one embodiment, the benzoic acid herbicide is dicamba.

In one embodiment, the benzoic acid herbicide is bispyribac-sodium.

Thus, in one embodiment, the present invention may provide a herbicidal combination comprising:

(a) At least one acetyl coa carboxylase inhibitor selected from clodinafop-propargyl, fluazinam, haloxyfop-methyl, quizalofop-ethyl, or a sugar grass ester, mesotrione, sulcotrione, cyclosulfamone, or pinoxaden;

(b) At least one photosynthesis II inhibitor selected from atrazine, hexazinone, oxaziclomefone, metribuzin, trifloxysulfuron, sulfentrazone, penoxsulam, saflufenacil, betametham, or bendiuron; and

(c) At least one microtubule assembly inhibitor herbicide selected from the group consisting of pendimethalin, diflufenican, fluroxypyr, picloram, sulfentrazone, dicamba, or bispyribac.

In a preferred embodiment, the combinations and methods of the invention comprise clodinafop-propargyl, a second herbicide and a third herbicide.

In a preferred embodiment, the second herbicide is selected from the group consisting of triazines, hexazinone, metamitron, metribuzin, carfentrazone-ethyl, trifloxysulfuron, sulfenacet, and penoxsulam.

In one embodiment, the third herbicide is a dinitroaniline herbicide.

In one embodiment, the present invention provides preferred combinations, compositions and methods thereof. The methods of the invention include methods of controlling weeds at a locus by applying the combination or composition to the locus, methods of increasing crop yield by applying the combination or composition, or methods of improving plant health by applying the combination or composition at the locus of the plant. The embodiments described herein describe preferred embodiments of all such possible combinations, compositions and methods of the invention.

Accordingly, one embodiment of the present invention provides a combination and method comprising clodinafop-propargyl; a second herbicide selected from the group consisting of triazines, hexazinone, metamitron, metribuzin, carfentrazone-ethyl, trifloxysulfuron, sulfentrazone, and penoxsulam. And a third herbicide selected from the group consisting of pendimethalin and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, triazine and amisulpride.

An embodiment of the present invention provides combinations and methods comprising clodinafop-propargyl, triazine and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, hexazinone, and amisulbrom.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, hexazinone, and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, oxaziclomefone and amisulbrom.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, oxaziclomefone and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, metribuzin and amisulpride.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, metribuzin and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, carfentrazone-ethyl and pendimethalin.

An embodiment of the present invention provides combinations and methods comprising clodinafop-propargyl, carfentrazone-ethyl and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, trifloxysulfuron and amisulbrom.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, trifloxysulfuron and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, sulfenamide and amisulpride.

An embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, sulfentrazone and pendimethalin.

One embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, penoxsulam, and pendimethalin.

An embodiment of the present invention provides a combination and method comprising clodinafop-propargyl, penoxsulam and pendimethalin.

In one embodiment, the combinations of the present invention include the following preferred combinations.

In one embodiment, each individual row appearing in the following table represents a combination in one embodiment of the present invention.

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In one embodiment, the invention may provide a combination comprising three herbicides listed in each individual row from row 1 to row 594 of the above table.

These combinations can be applied to the locus of the weeds in a herbicidally effective amount.

In one embodiment, the combination of the present invention may be combined with at least one other active substance, such as those active substances selected from, but not limited to, herbicides, insecticides, fungicides, biological agents, plant growth activators, fertilizers or combinations thereof.

Thus, in one embodiment, the combination of the invention may be combined with a herbicide. Exemplary herbicides that can be combined with the combinations of the present invention can be selected from, but are not limited to, herbicides belonging to the classes such as ALS inhibitors, EPSP synthase inhibitors, synthetic growth hormone, growth hormone transport inhibitors, glutamate synthase inhibitors, HPPD inhibitors, lipid synthesis inhibitors, long chain fatty acid inhibitors, and herbicides having an unknown mode of action.

In one embodiment, the total amount of clodinafop-propargyl in the composition may generally be in the range of from 0.1% to 99% by weight, preferably from 0.2% to 90% by weight.

In one embodiment, the total amount of pendimethalin in the composition may be in the range of 0.1 to 99% by weight.

In one embodiment, the total amount of metribuzin in the composition may be in the range of 0.1 wt% to 99 wt%.

In one embodiment, the combined constituent herbicides of the present invention can be blended accordingly in a ratio of (1-80): (1-80): (1-80) three herbicides.

In one embodiment, the combined constituent herbicides of the invention can be blended accordingly in a ratio of (1-80): (1-80): (1-80) clodinafop-propargyl, metribuzin and pendimethalin.

The herbicidal combinations of the present invention are useful for targeting weeds in crops such as corn, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, sugarcane, tobacco, and the like; vegetables: eggplant vegetables such as eggplant, tomato, sweet pepper, potato, etc., cucurbitaceous vegetables such as cucumber, pumpkin, zucchini, watermelon, melon, squash, etc., cruciferous vegetables such as radish, white radish, horseradish, cabbage, mustard, broccoli, cauliflower, etc., asteraceae vegetables such as burdock, garland chrysanthemum, artichoke, lettuce, etc., liliaceae vegetables such as green onion, garlic, and asparagus, non-starch (ammiaceus) vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceae vegetables such as spinach, lettuce, etc., mentha, basil, etc., strawberry, sweet potato, japanese yam, taro, etc., flowers, foliage plants, turf grass, fruit: pome fruits such as apples, pears, oranges, etc., stone fruits such as peaches, plums, nectarines, plums, cherry tomatoes, apricots, prunes, etc., citrus fruits such as oranges, lemons, lime, grapefruits, etc., nuts such as chestnuts, walnuts, hazelnuts, almonds, pistachios, cashews, hawaii nuts, etc., berries such as blueberries, cranberries, blackberries, raspberries, etc., grapes, persimmons, olives, plums, bananas, coffee, date coconut, etc., and trees other than fruit trees; tea tree, mulberry, flowering plant, trees such as chinese wax, birch, dogwood, eucalyptus, ginkgo, clove, maple, oak, poplar, cercis, sweetgum, syringa, zelkova, golden cypress, fir, hemlock, juniper, pine, spruce, yew, and the like.

In one aspect, the invention provides a composition of clodinafop-propargyl, pendimethalin and metribuzin.

In one embodiment, the compositions of the present invention may contain agriculturally acceptable adjuvants, carriers, diluents, emulsifiers, fillers, defoamers, thickeners, antifreeze agents, refrigerants, and the like. The composition may be solid or liquid. They may be solid, such as, for example, powders, granules, water-dispersible granules, microcapsules or wettable powders, or liquid, such as, for example, emulsifiable concentrates, solutions, emulsions or suspensions, ZC formulations. They may also be provided as a premix or mixed in a tank.

Suitable agricultural adjuvants and carriers can include, but are not limited to, crop oil concentrates; methylated seed oil, emulsified methylated seed oil, nonylphenol ethoxylate; benzyl cocoalkyl dimethyl quaternary ammonium salt; blends of petroleum hydrocarbons, alkyl esters, organic acids, and anionic surfactants; C9-C11 alkylpolyglycoside; a phosphorylated alcohol ethoxylate; natural primary alcohols (C12-C16) ethoxylates; di-sec-butylphenol EO-PO block copolymers; polysiloxane-methyl endcaps; nonylphenol ethoxylate, urea ammonium nitrate; tridecanol (synthetic) ethoxylate (8 EO); tallow amine ethoxylate; PEG (400) dioleate-99, alkyl sulfates such as diethanolammonium lauryl sulfate; alkylaryl sulfonates such as calcium dodecylbenzenesulfonate; alkylphenol-alkylene oxide addition products, such as nonylphenol-C ₁₈ An ethoxylate; alcohol-alkylene oxide addition products, e.g. tridecyl alcohol-C ₁₆ An ethoxylate; soaps such as sodium stearate; alkyl naphthalene sulfonates such as sodium dibutyl naphthalene sulfonate; dialkyl esters of sulfosuccinates, such as sodium bis (2-ethylhexyl) sulfosuccinate; sorbitol esters such as sorbitol oleate; quaternary amines such as lauryl trimethyl ammonium chloride; polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; salts of mono-and di-alkyl phosphates; vegetable or seed oils such as soybean oil, rapeseed oil/canola oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cottonseed oil, linseed oil, palm oil, peanut oil, safflower oil, sesame oil, tung oil, and the like; and esters of the above vegetable oils, and in certain embodiments, methyl esters.

Suitable liquid carriers useful in the compositions of the present invention may include water or organic solvents. Organic solvents include, but are not limited to, petroleum fractions or hydrocarbons such as mineral oils, aromatic solvents, paraffinic oils, and the like; vegetable oils such as soybean oil, rapeseed oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cottonseed oil, linseed oil, palm oil, peanut oil, safflower oil, sesame oil, tung oil, and the like; esters of the above vegetable oils; esters of mono-or di-, tri-or other lower polyols (containing 4-6 hydroxyl groups) such as 2-ethylhexyl stearate, n-butyl oleate, isopropyl myristate, propylene glycol dioleate, dioctyl succinate, dibutyl adipate, dioctyl phthalate and the like; esters of monocarboxylic acids, dicarboxylic acids, and polycarboxylic acids, and the like. Organic solvents include, but are not limited to, toluene, xylene, naphtha, crop oil, acetone, methyl ethyl ketone, cyclohexanone, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol monomethyl and diethylene glycol monomethyl ether, methanol, ethanol, isopropanol, amyl alcohol, ethylene glycol, propylene glycol, glycerol, N-methyl-2-pyrrolidone, N-dimethyl alkylamide, dimethyl sulfoxide.

Solid carriers useful in the compositions of the present invention may include, but are not limited to, attapulgite, pyrophyllite clay, silica, kaolin, sandy algae clay, chalk, diatomaceous earth, lime, calcium carbonate, bentonite clay, fuller's earth, talc, cotton seed hulls, wheat flour, soybean flour, pumice, wood flour, walnut hull flour, lignin, cellulose, and the like.

In one aspect, the invention provides a method of controlling weeds at a locus, the method comprises administering a combination of clodinafop-propargyl, pendimethalin and metribuzin.

Thus, embodiments of the present invention may provide a method of controlling weeds at a locus comprising applying a combination of clodinafop-propargyl, pendimethalin, metribuzin and optionally a fourth active substance.

In one embodiment, the fourth active substance may be selected from herbicides, insecticides, fungicides, biological agents, plant growth activators, fertilizers or combinations thereof.

The target weed may be selected from the group consisting of nigella sativa (Alopecurus myosuroides huds), almonds (black grass), ALOMY, amaranth (AMAPA), amaranth (8239), amaranth (amapp), avena fatua (Avena sativa amaranth), avena fatua (Avena sativa), flag grass (Brachiaria decumbens stapf), or nigella sativa (Urochloadecumbens (Stapf)), brachial grass (Brachiaria brizantha) or uiocarina, brachial grass (Brachiaria platyphylla (groeb)) Nash or uiocarpus (broadleaf signal grass (broadleaf signalgrass), BRAPP), plantain grass (Brachiaria plantaginea) or plantain arm grass (Urochloa plantaginea) (alexandrium (alergs), BRAPL), tribulus terrestris (Cenchrus echinatus) (southern tribulus terrestris (cenc)), ping Zhima tangutorum wilford (Jamaican crabgrass, DIGHO)), crabgrass (digitaria ailanthus (auricularia auricula), TRCIN), crabgrass (Digitaria sanguinalis (large Ma Tangcao (digsia)), barnyard grass (Echinochloa), echinochloa crux-galli (barnyard grass (echcgg)), echinochloa baryta (Echinochloa colonum) (jungle grass), echchoma (ECHCO), goosegrass (eleusines indica gaertn (goosegs), elegans), multiple flower ryegrass (Lolium mulberosum (Italian ryegrass), LOLMU)), panicum (Panicodichomatopsis (fall panicum), pandi (Pandi) millet L (wild millet) PANDI), millet (Panicomilleum L (wild millet), sesbania (sesbania) Sesbania (hempsebania), SEBEX, setaria faberi Herry (Guzi) (SETFA), green bristlegrass (green bristle), SETVI), stone (Sorghum halepense (Johnsonson (SORHA)), sorghum (Sorgum bicolor, moench ssp), spot (Arunacceum (shadow template), SORVU (Cyperus esculentus) (tsalow yellow sedge), CYPES), nutgrass (Cyperus rotundatus (CYPRO), abutilon (Abutilon theophrasti, abutilon (velvetl. F., ABUTH)), amaranth (Amaranthus species (pig grass and amaranth (pigweeds and amaranths), AMASS), ragweed (Ambrosia artemia latifolia) common ragweed (amberged), AMBEL, perennial ragweed (Ambrosia pastoris dc), ambrosia trilobata (ambrox), ambrosia trifolia tri (ambrox), amblycephala (amoda (cotton seed and cotton seed), ANVCR), ambrosia horse (Asclepias syriaca (common milk weed), asc, ambrosia nuda (common milk weed) Bidens pilosa (Mao Sanshe Bidens bipeda (hairy beggarticks), BIDPI), boreria species (BOISS), ficus latifolia (Boreria aleta) or Ficus latifolia (Specsurface aleta aubl.) or Ficus latifolia (Specercellula latifolia (broadleaf buttonweed), BOILF), quinoa (Chenopodium album L) (common quinoa (common lambsquarters), seal), herba Cephalanoploris (Cirsium arvense (Canada thistle), CIRAR), commelina (Commelina benghalensis (Tropical Commelina) (tropical spiderwort), COMBE), datura (Datura stramonium (Datura) wild carrot (Daucus carota wild), DAUCA), gorilla (Euphorbia heterophylla (wild red poncira), EPHHL), euphorbia (Euphorbia hirta) or Euphorbia (Chamaesyce hirta (EPHHI)), euphorbia pekinensis (Euphorbia dentata mix, euphorbia pekinensis (ephii)), EPHDE), chikura (Erigeron bonariensis) or chikura (Conyza bonariensis) (ERIBO) or erigeron (Erigeron canadensis) or erigeron (Conyza canadensis) (small white spirit (ercio), ercca), sulcus white spirit (Conyza sumatrensis (wild flibane), erigeron (ERIFL)) Sunflower (Helianthus annuus (common sun flower), HELAN), long stem Mao Efang vine (Jacque mosaic (smallflower morningglory), IAQTA), split petunia (Ipomoea hederacea (split petunia (ivyleaf morningglory), IPOHE), sweet potato (Ipomoea lacunosa (white morningglory), IPOLA), lettuce (Lacca sativa (multi-thorn Lettuce (LACSE)), herba Portulacae (Portulaca oleracea (common purslane) PORUS), herba Medicaginis (Richardia species (purslane (slide), RCHSS), sichuan lovage (Russian thistle), SASKR), sweet potato (Jin Wushi flowers), siberian lettuce (Siberian) herb (MDcarrier), sitsuki (latex), sitsuki (39) or wild herba Sitsuki (herba Sitsvali), herba Sitsvali (Tagetin), herba Sitsuki (Tagetin), herba Sitsurae (Tagetin) or herba Sitsurae (Tagetin) herb (Tagetis Erytherapy), herba Portulacae (Portulaca oleracea (common purslane), POOL (POLY) and herba Sitsuraae (POLY) herb (POLY).

In one embodiment, the combination of the invention may be applied to the locus simultaneously or sequentially such that the trifloxystrobin, the second herbicide, and the third herbicide may be applied as a pot mix or as a pre-mixed composition.

Thus, in this aspect, the present invention provides a canned mixture comprising:

In one embodiment, the invention may be applied before or after emergence of the seedlings. The advantage of this combination is a surprisingly good residual effect when applied pre-emergence and a quick knockout when applied post-emergence, resulting in a quick control of weeds. In another embodiment, the invention may be applied to burn off weeds rapidly. Another advantage is a quick knockout in the case of burn-out.

The control method of the present invention may be carried out by spraying the proposed canned mixture, or the individual herbicides may be formulated as a kit of parts containing the various components which may be mixed as indicated before spraying.

In one embodiment, the present invention provides a kit of parts comprising a plurality of components, wherein the plurality of components comprises:

(a) At least a first component comprising an acetyl-coa carboxylase inhibitor selected from an arylphenoxy propionate herbicide, a cyclohexanedione herbicide, or a phenylpyrazoline herbicide;

(b) At least a second component comprising a photosynthesis II inhibitor selected from a triazine herbicide, a triazone herbicide, a triazole herbicide, a triazolone herbicide, a uracil herbicide, a pyridazinone herbicide, a triazolopyrimidine herbicide, or a phenylcarbamate herbicide;

(c) At least a third component comprising a microtubule assembly inhibitor herbicide selected from the group consisting of a dinitroaniline herbicide, a phosphoramidate herbicide, a pyridine herbicide, a benzamide herbicide, or a benzoic acid herbicide.

In one embodiment, the kit of parts includes an instruction manual comprising instructions for the user to mix the components prior to use.

In one embodiment, the components of the present invention may be packaged such that clodinafop-propargyl, the first herbicide and the second herbicide may be packaged separately and then mixed in a tank prior to spraying.

In another embodiment, the components of the present invention may be packaged such that clodinafop-propargyl, the first herbicide and the second herbicide may be packaged separately, whereas the other additives are packaged separately such that the two may be mixed in a tank at the time of spraying.

In another embodiment, the components of the present invention may be packaged as a composition such that clodinafop-propargyl, the first herbicide and the second herbicide are formulated into one composition, and the other additives are packaged separately such that the two can be mixed in a can at the time of spraying.

Surprisingly, the present inventors have found that clodinafop-propargyl, the first herbicide and the second herbicide of the present invention are ineffective against weed control when applied alone, but exhibit excellent synergistic control when applied together. The combination controls weeds both pre-emergence and post-emergence. As will be demonstrated by the examples, the combination of clodinafop-propargyl, the first herbicide and the second herbicide synergistically controls broadleaf and grasses and sedge at the locus. Thus, the present invention provides an advantageous method of controlling weeds both pre-emergence and post-emergence. The methods of the present invention also provide a broader spectrum of control of weeds that aids in resistance management, thereby preventing weeds from being resistant to either herbicide, while providing a broader spectrum of control at lower rates of use.

Examples：

A field test was performed to examine the efficacy of the combination clodinafop-propargyl + metribuzin + pendimethalin. These tests on the percent weed control were performed in spring wheat crops. The results are described in table 1.

TABLE 1

There was no significant difference in the mean value followed by the same letter or symbol (p=.05, analysis of variance (Student-Newman-Keuls))

Mean comparison was only performed when AOV treatment P (F) was significant at mean comparison OSL.

Thus, in one embodiment, the present invention provides a combination comprising clodinafop-propargyl in an amount of 60g/ha, metribuzin in an amount of 252g/ha, and pendimethalin in an amount of 812 g/ha.

The results in table 1 clearly demonstrate the synergistic effect of clodinafop-propargyl + metribuzin and pendimethalin in controlling various weeds.

Thus, in one embodiment, it has surprisingly been found that the addition of a microtubule assembly inhibitor to a combination of a photosystem II inhibitor and an acetyl-coa carboxylase inhibitor results in a surprising and unexpected synergistic enhancement of the efficacy of the combination of photosystem II inhibitor and acetyl-coa carboxylase inhibitor.

In one embodiment, it has surprisingly been found that the addition of pendimethalin to a combination of clodinafop-propargyl and metribuzin results in a surprising and unexpected synergistic enhancement of the efficacy of the combination of clodinafop-propargyl and metribuzin.

In one embodiment, it has surprisingly been found that the addition of photosystem II inhibitors to a combination of microtubule assembly inhibitors and acetyl-coa carboxylase inhibitors results in a surprising and unexpected synergistic enhancement of the efficacy of the combination of microtubule assembly inhibitors and acetyl-coa carboxylase inhibitors.

In one embodiment, it has surprisingly been found that adding metribuzin to a combination of clodinafop-propargyl and pendimethalin results in a surprising and unexpected synergistic enhancement of the efficacy of the combination of clodinafop-propargyl and pendimethalin.

In one embodiment, it has surprisingly been found that the addition of an acetyl-coa carboxylase inhibitor to a combination of a microtubule assembly inhibitor and a photosystem II inhibitor results in a surprising and unexpected synergistic enhancement of the efficacy of the combination of the microtubule assembly inhibitor and the photosystem II inhibitor.

In this embodiment, it was surprisingly found that the addition of clodinafop-propargyl to the combination of metribuzin and pendimethalin resulted in a surprising and unexpected synergistic enhancement of the efficacy of the combination of metribuzin and pendimethalin.

In one embodiment, the present invention provides a combination comprising clodinafop-propargyl, pendimethalin and metribuzin, wherein pendimethalin and metribuzin are used in a ratio of about 6:1.

In one embodiment, the present invention provides a combination comprising clodinafop-propargyl, pendimethalin and metribuzin, wherein pendimethalin is used in an amount of about 384.4g/ha and metribuzin is used in an amount of about 65.6 g/ha.

In one embodiment, the present invention provides a combination comprising clodinafop-propargyl, pendimethalin and metribuzin, wherein pendimethalin and metribuzin are present in the form of ZC formulations.

In one embodiment, the present invention provides a combination comprising clodinafop-propargyl, pendimethalin and metribuzin, wherein the pendimethalin and metribuzin are present in the form of a ZC formulation, wherein the ZC formulation comprises a suspension of encapsulated pendimethalin and metribuzin.

In one embodiment, the present invention provides a combination comprising clodinafop-propargyl, pendimethalin and metribuzin, wherein the pendimethalin and metribuzin are present in the form of a ZC formulation, wherein the ZC formulation comprises a Capsule Suspension (CS) of pendimethalin and a Suspension (SC) of metribuzin.

While the above written description of the invention enables one of ordinary skill to make and use what is presently considered to be the best mode thereof, one of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiments, methods, and examples herein. Thus, the present invention should not be limited by the embodiments, methods, and examples described above, but should be limited by all embodiments and methods within the scope and spirit of the present invention.

Claims

1. A herbicidal combination comprising:

(a) At least one acetyl-CoA carboxylase inhibitor, selected from arylphenoxy propionate herbicides, cyclohexanedione herbicides or phenylpyrazoline herbicides;

2. The herbicidal combination of claim 1 wherein:

a. the aryl phenoxy propionate herbicide is selected from the group consisting of fluopicolide, clodinafop-propargyl, cyhalofop-butyl, belate, methyl ethyl fenoxaprop-p-ethyl, fenoxaprop-p-ethyl ethyl fenoxaprop-p-ethyl, fluazifop-p-butyl butyl fluazifop-p-butyl, quizalofop-p-butyl, fluazifop-butyl, quizalofop-p-ethyl, oxifen, quizalofop-ethyl, quizalofop-p-ethyl, quizalofop-ethyl and clomazone;

b. The cyclohexanedione herbicide is selected from the group consisting of fenitron, ketospiradox, lancotrione, mesotrione, sulcotrione, terfurrione, and cyclosulfamide;

c. the phenylpyrazoline herbicide is selected from the group consisting of iprovalicarb, flumetsulam, pinoxaden and pyriftalid.

3. The herbicidal combination of claim 1 wherein:

a. the triazine herbicide is selected from the group consisting of ipratropium, fumesamine, triamcinolone, atrazine, colazine, cyanazine, ciprofezin, liquorice, imazalil, atrazine, cyproconazole, aspoxicam, chlorphenazine, terbuthylazine, simazine, indac, triazamate, atraotype, etoxydim, chlorphenamine, amitraz, simetryn, terbutate, amethodim, atrazine, triazamate, triclopyr, isovalerate, methoprene, prometryn, simetryn and terbutryn;

b. the triazinone herbicide is selected from the group consisting of tertrazinone, terbutryn, buprofezin, hexazinone, temozolomide, metamitron, metribuzin and trifluoperazin;

c. the triazole herbicide is selected from the group consisting of clomazone, propiconazole, triazolesulfone and flumetsulam;

d. triazolone herbicide is selected from amicarbazone, cereal herbicides, carfentrazone-ethyl, flucarbazone-sodium, triazoxamide, prosulfuron, sulfentrazone-ethyl and thifensulfuron-methyl;

e. The triazolinone herbicide is selected from carfentrazone-ethyl, trifloxysulfuron and sulfentrazone;

f. uracil herbicides selected from the group consisting of bupirimate, triclopyr, flumetsulam, fluo Shan Bingmi, clomazone, saflufenacil, terfenacil or flumetsulam;

g. the pyridazinone herbicide is selected from chlorpyrifos chlorpyrifos, dichlord Mi Dasong Fluopyridazine, dimidazov, pyridaph or bida

h. The triazolopyrimidine herbicide is selected from the group consisting of clodinafop-propargyl, diclosulam, florasulam, flumetsulam, sulfentrazone, penoxsulam and pyroxsulam;

i. the phenylcarbamate herbicide is selected from the group consisting of betalain and bendiuron.

4. The herbicidal combination of claim 1 wherein:

a. the dinitroaniline herbicide is selected from the group consisting of flumetsulam, bubaling, clomazone, trifluralin, diltiazem, ethambutol, triamcinolone acetochlor, sulfenamide, pendimethalin, aminopropouline, ciprofloxacin and trifluralin;

b. the phosphoramidate herbicide is selected from the group consisting of methamidophos or imazalil;

c. the pyridine herbicide is selected from the group consisting of amiloride, iolopyr, clopyralid, diflufenican, dithiopyr, florpyr-azaxifen, flubenazolin, fluroxypyr, haloxyfop-butyl, picloram, flupirfenuron, clomazone, methoxam, thiabendazole, and triclopyr;

d. The benzamide herbicide is selected from propyzamide or clomazone;

e. the benzoic acid herbicide is selected from the group consisting of clomazone, oxadiazon, dicamba, 2,3,6-TBA, dicamba, bispyribac-sodium, pyribenzoxim, or pyriminobac-methyl.

5. A herbicidal composition comprising:

(c) At least one microtubule assembly inhibitor herbicide selected from the group consisting of dinitroaniline herbicides, phosphoramidate herbicides, pyridine herbicides, benzamide herbicides, or benzoic acid herbicides; and

(d) At least one agrochemically acceptable excipient.

6. A herbicidal combination comprising:

(b) At least one photosynthesis II inhibitor selected from atrazine, hexazinone, oxaziclomefone, metribuzin, trifloxysulfuron, sulfentrazone, penoxsulam, saflufenacil, or bendiuron; and

(c) At least one microtubule assembly inhibitor herbicide selected from the group consisting of pendimethalin, diflufenican, fluroxypyr, picloram, sulfentrazone, dicamba, or bispyribac-sodium.

7. A herbicidal combination comprising:

a. clodinafop-propargyl, hexazinone and amisulpride

b. Clodinafop-propargyl, hexazinone and pendimethalin

c. Clodinafop-propargyl, oxaziclomefone and amisulpride

d. Clodinafop-propargyl, oxaziclomefone and pendimethalin

e. Clodinafop-propargyl, metribuzin and amisulpride

f. Clodinafop-propargyl, metribuzin and pendimethalin

g. Clodinafop-propargyl, carfentrazone-ethyl and amisulpride

h. Clodinafop-propargyl, carfentrazone-ethyl and pendimethalin

i. Clodinafop-propargyl, trifloxysulfuron and amisulpride

j. Clodinafop-propargyl, trifloxysulfuron and pendimethalin

k. Clodinafop-propargyl, sulfenamide and amisulpride

Clodinafop-propargyl, sulfentrazone and pendimethalin

m. clodinafop-propargyl, penoxsulam and amisulpride

Clodinafop-propargyl, penoxsulam and pendimethalin.

8. A method of controlling weeds at a locus, wherein the method comprises applying to the locus a herbicidal combination comprising:

9. The method of claim 8, wherein the weed is Phalaris minor (Phalaris minor).

10. The method of claim 8, wherein the weed is a Rumex dentatus (Rumex dentatus).

11. A kit of parts comprising a plurality of components, wherein the plurality of components comprises: