CN116370538B - Traditional Chinese medicine composition for treating chicken laryngotracheitis and preparation method of oral liquid thereof - Google Patents
Traditional Chinese medicine composition for treating chicken laryngotracheitis and preparation method of oral liquid thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chicken laryngotracheitis and a preparation method of an oral liquid thereof, belonging to the technical field of poultry disease prevention and treatment. The traditional Chinese medicine composition provided by the invention comprises the following components in parts by weight: 15-20 parts of lonicera japonica, 15-20 parts of baical skullcap root, 15-20 parts of radix isatidis, 15-20 parts of rhizoma atractylodis, 15-20 parts of dried orange peel and 10 parts of liquorice. The traditional Chinese medicine composition is prepared into oral liquid, has high utilization rate of active ingredients, can be administered by drinking water, and is greatly convenient for clinical application. Clinical trial data indicate that: the cure rate of the traditional Chinese medicine oral liquid of the invention to chicken laryngotracheitis is 95-99%, the effective rate is 100%, and the treatment effect is remarkable. In addition, the oral liquid can also obviously reduce adverse reaction of the throat-transmitting vaccine to chicken immunity and reduce morbidity and mortality.
Description
Technical Field
The invention belongs to the technical field of poultry disease prevention and treatment, and in particular relates to a traditional Chinese medicine composition for treating chicken laryngotracheitis and a preparation method of oral liquid thereof.
Background
For the treatment of infectious laryngotracheitis of chicken, the treatment method commonly adopted by Western medicine is combining antiviral drug with antibiotic, and aims to relieve symptoms and reduce death rate. The common drugs are: amantadine, ribavirin, and sarcin. However, the antiviral drugs amantadine and ribavirin are forbidden at present, and the sarcin drugs have drug residues. But also damage the liver and kidney of the chicken to affect the growth and development of the chicken and the laying rate, and the problem of drug resistance is easy to occur.
The traditional Chinese veterinary medicine considers that the infectious laryngotracheitis of chickens belongs to the damp-heat disease category, and the disease is in the lung, and the symptoms are cough and asthma. In the prior art (Li Jingfeng, feng Guangyi, traditional Chinese medicine "Houning powder" is used for preventing and treating infectious laryngotracheitis of chickens [ J ]. J. Of traditional Chinese medicine, 2011,158 (1): 6.) AA of 32 days old is selected for preventing and treating the infectious laryngotracheitis of chickens by using the traditional Chinese medicine preparation "Houning powder", ILT virulent is used for counteracting toxic substances, and the result proves that the incidence rate of a control group is up to 78%, and the incidence rate of a prevention group is only 6%, so that the effect is remarkable. For the prevention and treatment of the disease, although a great deal of research is carried out by Chinese scholars, the exact curative effect of the traditional Chinese medicine in treating infectious laryngotracheitis of chickens is also proved, but the research results are only remained in dosage forms such as traditional Chinese medicine powder and the like, and the traditional Chinese medicine powder and the granular materials used in the current breeding cannot be uniformly stirred, so that the defect of large dosage difference of chickens is caused.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention aims to provide a traditional Chinese medicine composition for treating chicken laryngotracheitis and a preparation method of oral liquid thereof.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a Chinese medicinal composition comprises the following components in part by weight:
15-20 parts of lonicera japonica, 15-20 parts of baical skullcap root, 15-20 parts of radix isatidis, 15-20 parts of rhizoma atractylodis, 15-20 parts of dried orange peel and 10 parts of liquorice.
In a specific embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight:
20 parts of honeysuckle, 20 parts of baical skullcap root, 20 parts of indigowoad root, 15 parts of swordlike atractylodes rhizome, 15 parts of tangerine peel and 10 parts of liquoric root.
The application of the traditional Chinese medicine composition in preparing medicines for treating chicken laryngotracheitis.
A medicine for treating chicken laryngotracheitis contains the above Chinese medicinal composition as effective component.
In a specific embodiment, the medicament for treating chicken laryngotracheitis is in the form of an oral liquid.
In a specific embodiment, the preparation method of the drug for treating chicken laryngotracheitis comprises the following steps:
(1) sorting raw materials, and removing impurities in the raw materials;
(2) weighing the raw material components according to the following proportion;
(3) except for the baikal skullcap root, each raw material component is soaked in water with the weight of 10-12 times of the raw material at normal temperature for 5-15h;
(4) extracting the soaked liquid medicine mixture in the step (3) twice by steam heating, wherein the first time is that adding the baikal skullcap root before boiling the liquid medicine, keeping the liquid medicine slightly boiling for 1.0-2.0 hours, and extracting the extracting solution; adding 8-10 times of water into the residue after extracting the extractive solution, heating with steam for 1.0-2.0 hr, extracting the extractive solution again, and mixing the two medicinal liquids;
(5) concentrating the liquid medicine obtained in the step (4) into concentrated solution with the weight of 1 time of the original medicine weight;
(6) stirring and dissolving the concentrated solution in the step (5), and centrifuging to remove impurities in the liquid medicine, and collecting supernatant; the oral liquid for treating chicken laryngotracheitis is obtained.
For convenient storage and transportation, sodium benzoate with the liquid medicine amount of 0.2% can be added into the supernatant for corrosion prevention; the solution is then sub-filled, and autoclaved, in one embodiment, at 110℃ for 30 minutes.
The application of the traditional Chinese medicine composition in preparation of a preparation for reducing adverse reaction of a throat-transmitting vaccine on chicken immunity.
A preparation for reducing adverse effect of throat-transmitting vaccine on chicken immunity comprises the above Chinese medicinal composition as effective component.
In a specific embodiment, the preparation for reducing the adverse reaction of the throat-transmitting vaccine to chicken immunity is in the form of oral liquid.
In a specific embodiment, the preparation method of the preparation for reducing the adverse reaction of the throat-transmitting vaccine to chicken immunity is as follows:
(1) sorting raw materials, and removing impurities in the raw materials;
(2) weighing the raw material components according to the following proportion;
(3) except for the baikal skullcap root, each raw material component is soaked in water with the weight of 10-12 times of the raw material at normal temperature for 5-15h;
(4) extracting the soaked liquid medicine mixture in the step (3) twice by steam heating, wherein the first time is that adding the baikal skullcap root before boiling the liquid medicine, keeping the liquid medicine slightly boiling for 1.0-2.0 hours, and extracting the extracting solution; adding 8-10 times of water into the residue after extracting the extractive solution, heating with steam for 1.0-2.0 hr, extracting the extractive solution again, and mixing the two medicinal liquids;
(5) concentrating the liquid medicine obtained in the step (4) into concentrated solution with the weight of 1 time of the original medicine weight;
(6) stirring and dissolving the concentrated solution in the step (5), and centrifuging to remove impurities in the liquid medicine, and collecting supernatant; thus obtaining the preparation for reducing the adverse reaction of the throat-transmitting vaccine to chicken immunity.
For convenient storage and transportation, sodium benzoate with the liquid medicine amount of 0.2% can be added into the supernatant for corrosion prevention; the solution is then sub-filled, and autoclaved, in one embodiment, at 110℃ for 30 minutes.
The technical scheme of the invention has the advantages that:
1. the traditional Chinese medicine composition has the functions of clearing heat, removing toxicity, cooling blood, relieving sore throat and detumescence, and simultaneously has the functions of drying dampness, activating spleen, promoting qi and harmonizing stomach;
2. the oral liquid has the effects of clearing pathogenic agents on one hand, and relieving clinical symptoms of sore throat;
3. because the invention is a traditional Chinese medicine oral liquid, the administration is carried out by drinking water, each chicken is not required to be injected, the use is convenient, and the labor cost is saved.
4. The traditional Chinese medicine oral liquid for treating chicken laryngotracheitis has the advantages of safety and no medicine residue, and can be used for various stages of broiler chickens or laying hens, including the later growth stage and the egg laying stage of the broiler chickens.
The traditional Chinese medicine oral liquid prepared by the invention has high utilization rate of the effective components of the traditional Chinese medicine, can be administered by drinking water, and is greatly convenient for clinical application. Clinical trial data indicate that: the traditional Chinese medicine oral liquid of the invention is prepared by the following steps: 500 portions are diluted by clear water, the dosage is the normal water intake of chickens once a day, and the chicken is used for 5 days. Has a cure rate of 95-99% for chicken laryngotracheitis, an effective rate of 100% and a remarkable treatment effect. In addition, the oral liquid can also obviously reduce adverse reaction of the throat-transmitting vaccine to chicken immunity and reduce morbidity and mortality.
Detailed Description
The terms used in the present invention generally have meanings commonly understood by those of ordinary skill in the art unless otherwise indicated.
The invention will be described in further detail below in connection with specific embodiments and with reference to the data. The following examples are intended to illustrate the invention and are not intended to limit the scope of the invention in any way.
Example 1
A traditional Chinese medicine composition for treating chicken laryngotracheitis comprises the following components in parts by weight:
20 parts of honeysuckle, 20 parts of baical skullcap root, 20 parts of indigowoad root, 15 parts of swordlike atractylodes rhizome, 15 parts of tangerine peel and 10 parts of liquoric root.
Example 2
A traditional Chinese medicine composition for treating chicken laryngotracheitis comprises the following components in parts by weight:
20 parts of honeysuckle, 15 parts of baical skullcap root, 15 parts of indigowoad root, 20 parts of swordlike atractylodes rhizome, 20 parts of tangerine peel and 10 parts of liquoric root.
Example 3
A traditional Chinese medicine composition for treating chicken laryngotracheitis comprises the following components in parts by weight:
20 parts of honeysuckle, 20 parts of baical skullcap root, 15 parts of indigowoad root, 20 parts of swordlike atractylodes rhizome, 20 parts of tangerine peel and 10 parts of liquoric root
Example 4
A traditional Chinese medicine oral liquid for treating chicken laryngotracheitis is prepared by the following method:
(1) sorting raw materials, and removing impurities in the raw materials;
(2) weighing the following raw materials in proportion: 20g of lonicera japonica, 20g of scutellaria baicalensis, 20g of radix isatidis, 15g of rhizoma atractylodis, 15g of dried orange peel and 10g of liquorice.
(3) Adding the above components except Scutellariae radix into a multifunctional extraction tank, and soaking overnight with 10 times of clear water at normal temperature;
(4) extracting the soaked liquid medicine mixture in the step (3) twice by steam heating, adding radix Scutellariae before boiling the liquid medicine, keeping the liquid medicine slightly boiling (95-100 ℃) for 1.5 hours, and pumping the extracting solution into an extracting liquid tank. And adding clear water with the weight which is 8 times that of the raw materials into the dregs after the extraction liquid is pumped for the second time, heating by opening steam, slightly boiling for 1.5 hours, and pumping the extraction liquid into an extraction liquid tank again. Combining the two liquid medicines.
(5) Pumping the liquid medicine obtained in the step (4) into a double-effect concentrator in vacuum, and concentrating the liquid medicine into concentrated solution with the weight of 1 time of the original medicine by using the double-effect concentrator;
(6) pumping the concentrated solution obtained in the step (5) into a precipitation tank, stirring and dissolving for 30min, centrifuging by adopting a tube type centrifuge to remove impurities in the liquid medicine, and collecting supernatant; the oral liquid for treating chicken laryngotracheitis is obtained.
For convenient storage and transportation, adding preservative into the prepared oral liquid, weighing sodium benzoate according to the liquid medicine amount of 0.2%, and dissolving in the liquid medicine; packaging the liquid medicine into 500mL bottles; the filled oral liquid bottle is put into an autoclave and sterilized at 110 ℃ for 30 minutes.
Example 5
Effects of soaking time, feed-liquid ratio, extraction time and extraction times on preparation of Chinese medicinal oral liquid for treating chicken laryngotracheitis
Taking the feed-liquid ratio, the extraction time and the extraction times as investigation factors, carrying out L 9 (3 4 ) And (3) carrying out orthogonal test, and screening the optimal extraction conditions by taking the dry paste yield and the baicalin content as evaluation indexes (the weight coefficients of the dry paste yield and the baicalin content are calculated by 0.5), wherein the factor level is shown in the table 1 below.
TABLE 1 orthogonal level table
Weighing 20g of lonicera japonica, 20g of scutellaria baicalensis, 20g of radix isatidis, 15g of rhizoma atractylodis, 15g of dried orange peel and 10g of liquorice according to the prescription. In the test process, considering the damage of baicalin enzyme to baicalin, 5 other medicinal materials except for the baicalin medicinal material are heated first, and then the baicalin is added before boiling. Carrying out orthogonal test according to the conditions of Table 1, extracting to obtain 9 different extracting solutions, concentrating, standing, filtering, and collecting filtrate to constant volume of 50mL to obtain a process research sample.
Table 2 water extraction orthogonal test table
Note that: and (3) carrying out data analysis on two evaluation indexes of the water extraction orthogonal test by adopting comprehensive scores, wherein the weight coefficients of the dry paste yield and the baicalin content are calculated by 0.5.
The dry paste yield measurement method comprises the following steps:
the process study sample was precisely measured for 20mL, placed in an evaporation dish, dried to constant weight at 105℃and weighed to give dry paste weight (g), and the dry paste yield was calculated.
The baicalin content determination method comprises the following steps:
(1) Chromatographic conditions
Ufavour ODS-C18 (5 μm, 4.6X105 mm) column, available from Dalian Zhonghe Spectrum science and technology Co., ltd; mobile phase: methanol-water-glacial acetic acid (50:50:1); wavelength: 274nm; column temperature: 30 ℃; flow rate: 1.0mL/min. Baicalin reference (110715-201117) has a purity of 91.7% and is purchased from China food and drug inspection institute.
(2) Solution preparation
Preparation of a control solution: taking appropriate amount of baicalin reference substance, precisely weighing, and adding 50% methanol to obtain solution containing 0.16mg per 1 mL.
Preparation of test solution: precisely measuring 1mL of the product, placing in a 50mL measuring flask, adding a proper amount of 50% methanol, performing ultrasonic treatment for 20 minutes, standing to room temperature, adding 50% methanol to dilute to scale, shaking, filtering with a microporous filter membrane of 0.22 μm, and collecting the subsequent filtrate.
(3) Assay
Precisely sucking 5 μl of each of the reference solution and the sample solution, and measuring with a liquid chromatograph.
Dry extract yield score = sample dry extract yield/maximum dry extract yield x 0.5 x 100
Baicalin content score = sample baicalin content/maximum baicalin content x 0.5 x 100
Composite score = dry extract yield score + baicalin content score
The results of the orthogonal test show that A 2 B 1 C 2 D 3 For the best, the influence of each factor on the baicalin content is as follows in sequence: d is more than C and more than B is more than A, namely the reflux extraction times have the greatest influence on the extraction effect, the reflux extraction times have the least influence on the extraction effect by the water addition amount and the soaking time. Under the factor C, C 2 And C 3 The horizontal results are similar, and the reflux extraction is more reasonable for 1.5 hours from the perspective of water saving and energy saving; under the factor D, D 2 And D 3 The level is similar, and from the aspect of energy conservation, 2 times of reflux extraction are more reasonable. Therefore, the orthogonal test preferably results in B 1 C 2 D 2 Namely, except for the baikal skullcap root, adding 10 times of water (the first 10 times of water is soaked and then extracted, the second time of water adding is carried out because of 20% of liquid remained for the first time, the second time of water adding is carried out, 8 times of water is added), heating to boiling, adding the baikal skullcap root, and carrying out reflux extraction for 2 times, each time for 1.5 hours.
Example 6
Clinical test data of Chinese medicinal oral liquid
Application example 1: the 6200 chickens in Yongxing Zhenhuang rooster in Mianyang high new district can cause respiratory tract and eyeball inflammation after throat-transferring immunity.
Respiratory symptoms are: the chicken has the symptoms of mental depression, anorexia and dyspnea, and suddenly stretches up and forward to open the mouth and is accompanied by ringing and wheezing, severe wheezing and cough, and the cough is usually spasmodic and expectorates mucus or blood clots with blood.
The symptoms of eyeball inflammation are: the corners of the eye accumulate foamy secretions, tears, conjunctivitis, mild congestion of the eye, swelling of the eyelid and adhesions. Later stage corneal opacity, ulcer and infraorbital sinus swelling.
The traditional Chinese medicine oral liquid prepared in the embodiment 4 of the invention is added with 500mL of water for 500 jin, and is drunk in a concentrated way for 3-4 hours. The application is continued for 5 days. Cure rate: to eliminate dyspnea, the respiratory system is recovered to normal state, and the mental state and the feeding system are recovered to normal state. The method is effective: inclusion criteria are reduction of respiratory and eyeball inflammation disappearance for clinical symptoms such as respiratory tract. The result shows that the cure rate of the traditional Chinese medicine oral liquid prepared in the embodiment 4 of the invention to the chicken flock is 96%, and the effective rate is 100%.
Application example 2: 5000 local chickens of 35 days in the county of the fixed distance, the feed intake of a large group is reduced, zhang Koushen dyspnea, a strange call, 50-60 deaths per day, sometimes up to 80.
The traditional Chinese medicine oral liquid of the embodiment 4 of the invention is added with 500mL of water for 500 jin and is drunk intensively for 3-4 hours. The application was continued for 4 days. The large group returns to normal, and death falls to 1-2 days. The feed intake is also recovered to be normal. The result is counted, the cure rate is 99%, and the effective rate is 100%.
Example 7
Application of traditional Chinese medicine oral liquid in reducing immunization adverse reaction of throat-transmitting vaccine
The test chicken groups are selected to have good feeding management conditions, and 4 chicken farms with more than 2 thousands of laying hens are fed in each farm, and the same infectious laryngotracheitis vaccine is adopted for immunization in the same immunization mode. Wherein the control group 1 and 2 are two replicates of the control design, the 3 and 4 are two replicates of the test design, and the number of chickens in each group is 20000 feathers. The test group uses the oral liquid prepared in the embodiment 4 of the invention 3 days before immunization, 500 jin of water is added into each 500mL of the oral liquid, the oral liquid is concentrated to drink for 3 to 4 hours, the oral liquid is used for 3 days, and the control group does not carry out any treatment. The test group and the control group were immunized with the same throat-transmitting vaccine at the same age of day, and after immunization, adverse immune reaction was observed, and the morbidity and mortality of each group were recorded. The specific test results are shown in Table 3 below.
Table 3 results of immunization groups
Remarks: immune adverse reaction: reduced feed intake, lacrimation, eye swelling, cough, and asthma.
From the test data in table 3, it can be seen that the oral liquid of the present invention has an effective rate of 99.5% (the effective rates of the two test groups are 100% and 99%, respectively, and the average value is 99.5%) for preventing and controlling vaccine immune adverse reaction. The average incidence rate of vaccine control groups which are not prevented by using the medicine reaches 62%, so that the oral liquid has obvious effect of controlling adverse reaction of the vaccine.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the invention in any way, and any person skilled in the art may make modifications or alterations to the disclosed technical content to the equivalent embodiments. However, any simple modification, equivalent variation and variation of the above embodiments according to the technical substance of the present invention still fall within the protection scope of the technical solution of the present invention.
Claims (6)
1. The traditional Chinese medicine composition for reducing the adverse reaction of the throat-transmitting vaccine to chicken immunity is characterized by comprising the following components in parts by weight:
15-20 parts of lonicera japonica, 15-20 parts of baical skullcap root, 15-20 parts of radix isatidis, 15-20 parts of rhizoma atractylodis, 15-20 parts of dried orange peel and 10 parts of liquorice.
2. The traditional Chinese medicine composition for reducing adverse effects of throat-transfer vaccine on chicken immunity according to claim 1, which is characterized by comprising the following components in parts by weight:
20 parts of honeysuckle, 20 parts of baical skullcap root, 20 parts of indigowoad root, 15 parts of swordlike atractylodes rhizome, 15 parts of tangerine peel and 10 parts of liquoric root.
3. The use of the traditional Chinese medicine composition according to claim 1 or 2 in the preparation of a preparation for reducing adverse effects of a throat-transmitting vaccine on chicken immunity.
4. A preparation for reducing adverse effects of a throat-transmitting vaccine on chicken immunity, which is characterized by being prepared from the traditional Chinese medicine composition and auxiliary materials in claim 1 or 2.
5. The formulation for reducing adverse effects of a throat-transmitting vaccine on chicken according to claim 4, wherein the formulation is an oral liquid.
6. The formulation for reducing adverse effects of a throat-transmitting vaccine on chicken according to claim 5, wherein the preparation method comprises the following steps:
(1) sorting raw materials, and removing impurities in the raw materials;
(2) weighing the raw material components according to the proportion;
(3) except for the baikal skullcap root, each raw material component is soaked in water with the weight of 10-12 times of the raw material at normal temperature for 5-15h;
(4) extracting the soaked liquid medicine mixture in the step (3) twice by steam heating, wherein the first time is that adding the baikal skullcap root before boiling the liquid medicine, keeping the liquid medicine slightly boiling for 1.0-2.0 hours, and extracting the extracting solution; adding 8-10 times of water into the residue after extracting the extractive solution, heating with steam for 1.0-2.0 hr, extracting the extractive solution again, and mixing the two medicinal liquids;
(5) concentrating the liquid medicine obtained in the step (4) into concentrated solution with the weight of 1 time of the original medicine weight; (6) stirring and dissolving the concentrated solution in the step (5), and centrifuging to remove impurities in the liquid medicine, and collecting supernatant; thus obtaining the preparation for reducing the adverse reaction of the throat-transmitting vaccine to chicken immunity.
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