CN116369912A - Blood oxygen measurement system and method combining Raman spectrum with PPG - Google Patents
Blood oxygen measurement system and method combining Raman spectrum with PPG Download PDFInfo
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 239000008280 blood Substances 0.000 title claims abstract description 64
- 210000004369 blood Anatomy 0.000 title claims abstract description 64
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 64
- 239000001301 oxygen Substances 0.000 title claims abstract description 64
- 238000001237 Raman spectrum Methods 0.000 title claims abstract description 28
- 238000005259 measurement Methods 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims abstract description 13
- 238000001069 Raman spectroscopy Methods 0.000 claims abstract description 35
- 238000001228 spectrum Methods 0.000 claims abstract description 23
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 22
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 22
- 238000004458 analytical method Methods 0.000 claims abstract description 15
- 238000006213 oxygenation reaction Methods 0.000 claims abstract description 13
- 108010064719 Oxyhemoglobins Proteins 0.000 claims abstract description 9
- 238000002496 oximetry Methods 0.000 claims description 10
- 230000003595 spectral effect Effects 0.000 claims description 6
- 230000000630 rising effect Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 5
- 238000000691 measurement method Methods 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 6
- 208000035473 Communicable disease Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
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Abstract
The invention provides a Raman spectrum combined PPG blood oxygen measurement system and a method, comprising the following steps: the first LED emitter and the second LED emitter respectively emit a first signal spectrum and a second signal spectrum to the tested tissue; after the laser projects laser to the tested tissue, a Raman signal of the oxyhemoglobin is excited; a first PD detector for receiving PPG signal light fed back by the tissue under test and generating a PPG signal; a second PD detector and a third PD detector for acquiring raman signals of the blood oxygen proteins for calculating blood oxygen saturation; and the analysis control unit is used for receiving the PPG signal, and when the analog value of the PPG signal is in an extreme value state, the analysis control unit sends a control instruction to turn on the laser. According to the Raman spectrum combined PPG blood oxygen measurement system and the Raman spectrum combined PPG signal, the oxygenation saturation of blood oxygen proteins in the tissue to be measured can be accurately measured, and the Raman spectrum combined PPG blood oxygen measurement system and the Raman spectrum combined PPG blood oxygen measurement method are suitable for health detection equipment.
Description
Technical Field
The invention relates to the technical field of photoelectric detection, in particular to a blood oxygen measurement system and method by combining Raman spectrum with PPG.
Background
When a human body breathes, the PPG signal intensity generated by the wavelength sensitive to the blood oxygen concentration in the system also fluctuates, if the wavelength is insensitive to the blood oxygen concentration, the signal intensity is expressed as a direct current signal and does not change along with the breathing movement, so that the problem that the oxygenation saturation of the blood oxygen protein cannot be accurately obtained exists.
Therefore, it is necessary to provide a system and a method for measuring blood oxygen by combining raman spectrum with PPG, so as to effectively solve the above-mentioned problems.
Disclosure of Invention
The invention provides a Raman spectrum combined PPG blood oxygen measurement system and a Raman spectrum combined PPG signal, which can accurately measure the oxygenation saturation of blood oxygen proteins in a measured tissue and are suitable for health detection equipment.
The embodiment of the invention provides a blood oxygen measurement system combining Raman spectrum with PPG, which comprises:
a first LED emitter and a second LED emitter, the first LED emitter having a first emission wavelength, the second LED emitter having a second emission wavelength, the first LED emitter and the second LED emitter emitting a first signal spectrum and a second signal spectrum, respectively, to a tissue under test;
a laser having a third emission wavelength, wherein the laser emits laser light to the tissue to be measured and then excites a raman signal of the oxyhemoglobin;
a first PD detector for receiving PPG signal light fed back by the tissue under test and generating a PPG signal;
a second PD detector and a third PD detector for acquiring raman signals of the blood oxygen proteins for calculating blood oxygen saturation;
and the analysis control unit is used for receiving the PPG signal, judging whether the analog value of the PPG signal is in an extremum state, and sending a control instruction to turn on the laser when the analog value of the PPG signal is in the extremum state.
Preferably, the extremum state is obtained by analyzing rising and falling edges of a waveform of the PPG signal.
Preferably, the extremum state comprises a maximum value of an analog value of the PPG signal and a minimum value of an analog value of the PPG signal, the output signal of the second PD detector being recorded when the analog value of the PPG signal is at the minimum value, the output signal of the third PD detector being recorded when the analog value of the PPG signal is at the maximum value.
Preferably, the blood oxygen saturation is calculated specifically by the following formula:
wherein PR represents the peak ratio of characteristic peak, I PD2 Representing the intensity of the signal current generated by the second PD detector, I PD3 Representing the signal current strength produced by the third PD detector.
Preferably, the second PD detector and the third PD detector include a first narrowband filter and a second narrowband filter, respectively, and the first narrowband filter and the second narrowband filter correspond to spectral signals of a certain characteristic peak of the blood oxygen protein before and after oxygenation, respectively.
Preferably, the first PD detector and the third PD detector correspond to spectral signals at two positions 1555cm-1 and 1585cm-1, respectively.
Preferably, the third emission wavelength of the laser is in the range 700-1500 nm.
Preferably, the power of the laser is in the range of 10-50 mW.
Preferably, the third emission wavelength of the laser is 1064nm, and the power of the laser is 30mW.
The embodiment of the invention also provides a blood oxygen measurement method combining Raman spectrum with PPG, which comprises the following steps:
the first LED emitter and the second LED emitter respectively emit a first signal spectrum and a second signal spectrum to the tested tissue;
a first PD detector receives PPG signal light fed back by the tested tissue and generates a PPG signal;
an analysis control unit receives the PPG signal;
judging whether the analog value of the PPG signal is in an extremum state, and when the analog value of the PPG signal is in the extremum state, sending a control instruction by the analysis control unit to turn on the laser;
after the laser projects laser to the tested tissue, a Raman signal of the oxyhemoglobin is excited;
the second PD detector and the third PD detector acquire Raman signals of the blood oxygen proteins, and the Raman signals of the blood oxygen proteins are used for calculating blood oxygen saturation;
the output signal of the second PD detector is recorded when the analog value of the PPG signal is at a minimum value, and the output signal of the third PD detector is recorded when the analog value of the PPG signal is at a maximum value.
Compared with the prior art, the technical scheme of the embodiment of the invention has the following beneficial effects:
the embodiment of the invention provides a blood oxygen measurement system and a method combining Raman spectrum with PPG, comprising the following steps: a first LED emitter and a second LED emitter, the first LED emitter having a first emission wavelength, the second LED emitter having a second emission wavelength, the first LED emitter and the second LED emitter emitting a first signal spectrum and a second signal spectrum, respectively, to a tissue under test; a laser having a third emission wavelength, wherein the laser emits laser light to the tissue to be measured and then excites a raman signal of the oxyhemoglobin; a first PD detector for receiving PPG signal light fed back by the tissue under test and generating a PPG signal; a second PD detector and a third PD detector for acquiring raman signals of the blood oxygen proteins for calculating blood oxygen saturation; the analysis control unit is used for receiving the PPG signal, judging whether the analog value of the PPG signal is in an extremum state, and sending a control instruction to turn on the laser when the analog value of the PPG signal is in the extremum state, and accurately measuring the oxygenation saturation of the blood oxygen protein in the tested tissue by combining the PPG signal through Raman spectrum, so that the analysis control unit is suitable for health detection equipment;
further, the extremum state includes a maximum value of the analog value of the PPG signal and a minimum value of the analog value of the PPG signal, when the analog value of the PPG signal is at the minimum value, the output signal of the second PD detector is recorded, and when the analog value of the PPG signal is at the maximum value, the output signal of the third PD detector is recorded, so that noise of the PPG signal is effectively filtered, and the saturation of the blood oxygen protein in the tissue to be measured is measured more accurately.
Furthermore, the laser signal emitted by the laser is used for dynamically measuring the blood oxygen, so that the non-contact and non-damage can be realized, the risk of contact between medical equipment and a patient is effectively reduced, and the infection probability of infectious diseases is reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the prior art, a brief description of the drawings is provided below, wherein it is apparent that the drawings in the following description are some, but not all, embodiments of the present invention. Other figures may be derived from these figures without inventive effort for a person of ordinary skill in the art.
Fig. 1 is a schematic structural diagram of a raman spectrum combined with PPG blood oxygen measurement system according to an embodiment of the present invention;
fig. 2 is a signal schematic diagram of a first signal spectrum and a second signal spectrum emitted by a first LED emitter and a second LED emitter of a blood oxygen measurement system with raman spectrum combined with PPG according to an embodiment of the present invention;
fig. 3 is a schematic diagram of an original pulse wave waveform of an oximetry system combining raman spectroscopy with PPG according to an embodiment of the present invention;
fig. 4 is a flow chart of a method for measuring blood oxygen by combining raman spectrum with PPG according to an embodiment of the present invention.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The technical scheme of the invention is described in detail below by specific examples. The following embodiments may be combined with each other, and some embodiments may not be repeated for the same or similar concepts or processes.
Based on the problems existing in the prior art, the embodiment of the invention provides a system and a method for measuring blood oxygen by combining a Raman spectrum with a PPG (Photoplethysmographic), which can accurately measure the oxygenation saturation of blood oxygen protein in a tested tissue by combining the Raman spectrum with a PPG signal, and are suitable for health detection equipment.
Fig. 1 is a schematic structural diagram of a raman spectrum combined with PPG blood oxygen measurement system according to an embodiment of the present invention; fig. 2 is a signal schematic diagram of a first signal spectrum and a second signal spectrum emitted by a first LED emitter and a second LED emitter of a blood oxygen measurement system with raman spectrum combined with PPG according to an embodiment of the present invention.
Referring now to fig. 1-2, an embodiment of the present invention provides a raman spectroscopy combined with PPG blood oxygen measurement system, comprising:
a first LED (Light-Emitting Diode) emitter and a second LED emitter, the first LED emitter having a first emission wavelength and the second LED emitter having a second emission wavelength, the first LED emitter and the second LED emitter Emitting a first signal spectrum and a second signal spectrum, respectively, to a tissue under test;
a laser having a third emission wavelength, wherein the laser emits laser light to the tissue to be measured and then excites a raman signal of the oxyhemoglobin;
a first PD (photodiode) detector for receiving PPG signal light fed back by the tissue under test and generating a PPG signal;
a second PD detector and a third PD detector for acquiring raman signals of the blood oxygen proteins for calculating blood oxygen saturation;
and the analysis control unit is used for receiving the PPG signal, judging whether the analog value of the PPG signal is in an extremum state, and sending a control instruction to turn on the laser when the analog value of the PPG signal is in the extremum state.
Fig. 3 is a schematic diagram of an original pulse wave waveform of an oximetry system combining raman spectrum with PPG according to an embodiment of the present invention, referring now to fig. 3, it can be seen that the original pulse wave waveform has extreme values, i.e. a maximum value and a minimum value.
In a specific implementation, the extremum state is obtained by analyzing rising and falling edges of a waveform of the PPG signal.
In a specific implementation, the extremum state includes a maximum value of an analog value of the PPG signal and a minimum value of an analog value of the PPG signal, the output signal of the second PD detector is recorded when the analog value of the PPG signal is at the minimum value, and the output signal of the third PD detector is recorded when the analog value of the PPG signal is at the maximum value.
In a specific implementation, the blood oxygen saturation is calculated specifically by the following formula:
wherein PR represents the peak ratio of characteristic peak, I PD2 Representing the intensity of the signal current generated by the second PD detector, I PD3 Representing the signal current strength produced by the third PD detector.
Specifically, since the signal excited by the laser is a spectrum in which several fixed characteristic peaks can represent the degree of blood oxygen saturation, the blood oxygen saturation can be calculated from the peak ratio of the characteristic peaks.
In a specific implementation, the second PD detector and the third PD detector include a first narrowband filter and a second narrowband filter, respectively, where the first narrowband filter and the second narrowband filter correspond to spectral signals of a certain characteristic peak of the hemoglobin before and after oxygenation, respectively.
Specifically, the total of 3 raman characteristic peaks of the blood oxygen proteins, which can be used for detecting the oxygenation degree, are respectively: 1360cm-1, 1605cm-1, 1555cm-1. The second PD detector and the third PD detector respectively correspond to Raman shift of a certain characteristic peak before and after oxygenation.
In an implementation, the first PD detector and the third PD detector correspond to spectral signals at two positions 1555cm-1 and 1585cm-1, respectively. Two positions of 1555cm-1 and 1585cm-1 are before and after the oxygenation of one characteristic peak, so the first PD detector and the third PD detector respectively correspond to the Raman shift of the 1555cm-1 characteristic peak before and after the oxygenation, and the characteristic peak can be determined. In a specific implementation, the third emission wavelength of the laser ranges from 700 to 1500nm.
In a specific implementation, the power of the laser is in the range of 10-50 mW.
In a specific implementation, the third emission wavelength of the laser is 1064nm, and the power of the laser is 30mW.
Fig. 4 is a flow chart of a method for measuring blood oxygen by combining raman spectrum with PPG according to an embodiment of the present invention. Referring now to fig. 4, an embodiment of the present invention further provides a method for measuring blood oxygen by combining raman spectrum with PPG, including:
step S401: the first LED emitter and the second LED emitter respectively emit a first signal spectrum and a second signal spectrum to the tested tissue;
step S402: a first PD detector receives PPG signal light fed back by the tested tissue and generates a PPG signal;
step S403: an analysis control unit receives the PPG signal;
step S404: judging whether the analog value of the PPG signal is in an extremum state, and when the analog value of the PPG signal is in the extremum state, sending a control instruction by the analysis control unit to turn on the laser;
step S405: after the laser projects laser to the tested tissue, a Raman signal of the oxyhemoglobin is excited;
step S406: the second PD detector and the third PD detector acquire Raman signals of the blood oxygen proteins, and the Raman signals of the blood oxygen proteins are used for calculating blood oxygen saturation;
step S407: the output signal of the second PD detector is recorded when the analog value of the PPG signal is at a minimum value, and the output signal of the third PD detector is recorded when the analog value of the PPG signal is at a maximum value.
In summary, the system and the method for measuring blood oxygen by combining raman spectrum with PPG provided by the embodiment of the invention comprise the following steps: a first LED emitter and a second LED emitter, the first LED emitter having a first emission wavelength, the second LED emitter having a second emission wavelength, the first LED emitter and the second LED emitter emitting a first signal spectrum and a second signal spectrum, respectively, to a tissue under test; a laser having a third emission wavelength, wherein the laser emits laser light to the tissue to be measured and then excites a raman signal of the oxyhemoglobin; a first PD detector for receiving PPG signal light fed back by the tissue under test and generating a PPG signal; a second PD detector and a third PD detector for acquiring raman signals of the blood oxygen proteins for calculating blood oxygen saturation; the analysis control unit is used for receiving the PPG signal, judging whether the analog value of the PPG signal is in an extremum state, and sending a control instruction to turn on the laser when the analog value of the PPG signal is in the extremum state, and accurately measuring the oxygenation saturation of the blood oxygen protein in the tested tissue by combining the PPG signal through Raman spectrum, so that the analysis control unit is suitable for health detection equipment;
further, the extremum state includes a maximum value of the analog value of the PPG signal and a minimum value of the analog value of the PPG signal, when the analog value of the PPG signal is at the minimum value, the output signal of the second PD detector is recorded, and when the analog value of the PPG signal is at the maximum value, the output signal of the third PD detector is recorded, so that noise of the PPG signal is effectively filtered, and the saturation of the blood oxygen protein in the tissue to be measured is measured more accurately.
Furthermore, the laser signal emitted by the laser is used for dynamically measuring the blood oxygen, so that the non-contact and non-damage can be realized, the risk of contact between medical equipment and a patient is effectively reduced, and the infection probability of infectious diseases is reduced.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (10)
1. An oximetry system incorporating raman spectroscopy with PPG, comprising:
a first LED emitter and a second LED emitter, the first LED emitter having a first emission wavelength, the second LED emitter having a second emission wavelength, the first LED emitter and the second LED emitter emitting a first signal spectrum and a second signal spectrum, respectively, to a tissue under test;
a laser having a third emission wavelength, wherein the laser emits laser light to the tissue to be measured and then excites a raman signal of the oxyhemoglobin;
a first PD detector for receiving PPG signal light fed back by the tissue under test and generating a PPG signal;
a second PD detector and a third PD detector for acquiring raman signals of the blood oxygen proteins for calculating blood oxygen saturation;
and the analysis control unit is used for receiving the PPG signal, judging whether the analog value of the PPG signal is in an extremum state, and sending a control instruction to turn on the laser when the analog value of the PPG signal is in the extremum state.
2. The raman spectroscopy-combined PPG oximetry system according to claim 1, wherein the extremum condition is obtained by analyzing rising and falling edges of the waveform of the PPG signal.
3. The raman spectroscopy-PPG-combined oximetry system according to claim 1, wherein the extremum condition comprises a maximum of an analog value of the PPG signal and a minimum of an analog value of the PPG signal, the output signal of the second PD detector being recorded when the analog value of the PPG signal is at the minimum, the output signal of the third PD detector being recorded when the analog value of the PPG signal is at the maximum.
4. A raman spectroscopy combined PPG oximetry system according to claim 3, wherein the blood oxygen saturation is calculated specifically by the following formula:
wherein PR represents the peak ratio of characteristic peak, I PD2 Representing the intensity of the signal current generated by the second PD detector, I PD3 Representing the signal current strength produced by the third PD detector.
5. The raman spectroscopy-PPG-combined oximetry system according to claim 1, wherein the second and third PD detectors comprise a first and second narrowband filter, respectively, that correspond to the spectral signals of a characteristic peak of the oximeter before and after oxygenation, respectively.
6. The raman spectroscopy combined PPG oximetry system according to claim 1, wherein the second PD detector and the third PD detector correspond to spectral signals at two locations 1555cm "1 and 1585 cm" 1, respectively.
7. The raman spectroscopy-PPG-combined oximetry system according to claim 1, wherein the third emission wavelength of the laser is in the range 700-1500 nm.
8. The raman spectroscopy combined PPG oximetry system according to claim 1, wherein the power of the laser is in the range of 10-50 mW.
9. The raman spectroscopy-PPG blood oxygen measurement system according to claim 1, wherein the third emission wavelength of the laser is 1064nm and the power of the laser is 30mW.
10. A method for measuring blood oxygen by combining raman spectrum with PPG, comprising:
the first LED emitter and the second LED emitter respectively emit a first signal spectrum and a second signal spectrum to the tested tissue;
a first PD detector receives PPG signal light fed back by the tested tissue and generates a PPG signal;
an analysis control unit receives the PPG signal;
judging whether the analog value of the PPG signal is in an extremum state, and when the analog value of the PPG signal is in the extremum state, sending a control instruction by the analysis control unit to turn on the laser;
after the laser projects laser to the tested tissue, a Raman signal of the oxyhemoglobin is excited;
the second PD detector and the third PD detector acquire Raman signals of the blood oxygen proteins, and the Raman signals of the blood oxygen proteins are used for calculating blood oxygen saturation;
the output signal of the second PD detector is recorded when the analog value of the PPG signal is at a minimum value, and the output signal of the third PD detector is recorded when the analog value of the PPG signal is at a maximum value.
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| US20140114151A1 (en) * | 2012-10-19 | 2014-04-24 | Convergence Biometrics, LLC | Noninvasive blood measurement platform |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20140114151A1 (en) * | 2012-10-19 | 2014-04-24 | Convergence Biometrics, LLC | Noninvasive blood measurement platform |
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| Title |
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| BRAZHE NA, THOMSEN K, LØNSTRUP M, BRAZHE AR, NIKELSHPARG EI, MAKSIMOV GV, LAURITZEN M, SOSNOVTSEVA O.: "Monitoring of blood oxygenation in brain by resonance Raman spectroscopy", 《J BIOPHOTONICS》, pages 1 - 10 * |
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