CN116359122A - Device and method for experimental scouring of implant machinery in antibacterial coating capable of simulating body fluid flow state - Google Patents
Device and method for experimental scouring of implant machinery in antibacterial coating capable of simulating body fluid flow state Download PDFInfo
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- 238000000576 coating method Methods 0.000 title claims abstract description 46
- 239000011248 coating agent Substances 0.000 title claims abstract description 42
- 238000009991 scouring Methods 0.000 title claims abstract description 32
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- 239000010839 body fluid Substances 0.000 title claims abstract description 29
- 239000007943 implant Substances 0.000 title claims abstract description 27
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000011010 flushing procedure Methods 0.000 claims abstract description 110
- 239000007788 liquid Substances 0.000 claims abstract description 106
- 238000012360 testing method Methods 0.000 claims abstract description 30
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N19/00—Investigating materials by mechanical methods
- G01N19/04—Measuring adhesive force between materials, e.g. of sealing tape, of coating
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
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Abstract
The invention discloses an antimicrobial coating internal implant mechanical scouring experiment device capable of simulating body fluid flow state and an experiment method. The device comprises a flushing liquid circulation system, a filtering system, a voltage stabilizing system and a multi-stage serial sample bin which are sequentially connected in series to form a flushing main loop, and also comprises a monitoring system, an alarm system and a flushing liquid automatic supplementing system which are connected in parallel to the flushing main loop, wherein the flushing main loop is uniformly controlled and data managed by a computer control system. And outputting flushing liquid through a flushing liquid circulating system, filtering through a filtering system, regulating and controlling the flushing pressure of the solution through a pressure stabilizing system to simulate the flushing state of body fluid, and entering a sample bin to realize the flushing test of the coating sample. The device provided by the invention can simulate the body fluid flowing state in vivo, accurately realize the simulation evaluation of the stability of the implant after mechanical implantation in the antibacterial coating, and has important significance for evaluating the safety and stability of the implant instrument product in the antibacterial coating before marketing.
Description
Technical Field
The invention relates to the field of research and development of medical implant instruments, in particular to an implant instrument scouring experimental device in an antibacterial coating capable of simulating the flowing state of body fluid and a test method thereof.
Background
Defects and hypofunction of bones and joints of the human body are always clinical problems which plague orthopedics doctors. In recent years, this clinical problem has been remedied by implanting implants in the human body as a replacement for the defect. However, when these metal grafts are surgically transplanted into the body, there is a high probability of infection at the surgical site after surgery. Bacterial infection and the resultant biofilm can cause failure of implantation procedures, recurrence of inflammation, and a series of concomitant complications, which can greatly increase patient recovery difficulties and also greatly increase patient physiological, psychological and economic burdens.
In view of the above problems, antimicrobial coating techniques are a good means of solving post-operative infections of implanted devices, such as antibiotic coatings, iodine coatings, silver coatings, and antimicrobial peptide coatings, among others. Although the technology of the antibacterial coating has been greatly focused by researchers in recent years, the antibacterial effect or intelligent responsive coating and the like have been greatly improved, the bonding force between the antibacterial coating and the substrate is always a difficult problem to be overcome in the field, and meanwhile, how to realize the simulation detection of the bonding strength of the antibacterial coating has important significance for improving the bonding strength and verifying the stability of the coating.
At present, the detection of the antibacterial coating mainly comprises the steps of using a universal testing machine to perform a bonding strength test, a high-temperature stability test, an antifriction test and the like, but the detection is single in-vitro detection, and no method for simulating the environment of the antibacterial coating implant in a human body or detecting the stability of the antibacterial coating implant in the human body exists. Implants are subject to blood washout and erosion throughout the body, and after washout aging the antimicrobial effectiveness of the coating will be affected, with serious consequences once the coating is shed, so the coating must be subjected to washout tests to evaluate its bond strength, as well as stability and safety in the body, before it can be used. Therefore, the invention designs an antimicrobial coating inner implant mechanical scouring experiment device capable of simulating the flowing state of body fluid so as to solve the problems.
Disclosure of Invention
Aiming at the defects of the prior art, the invention designs an antibacterial coating internal implant mechanical scouring experimental device capable of simulating the flowing state of body fluid and a test method thereof in order to simulate the state of an implant mechanical implanted in a body so as to ensure the performance stability of an antibacterial coating product before the product is put into use
The technical scheme adopted by the invention is as follows:
an antimicrobial coated implant mechanical flush test device capable of simulating body fluid flow conditions, the device comprising: the system comprises a flushing liquid circulation system, a filtering system, a voltage stabilizing system and a multistage serial sample bin which are sequentially connected in series to form a flushing loop, wherein flushing liquid simulating body fluid is output through the flushing liquid circulation system, filtered through the filtering system, and the flushing state of the body fluid is simulated through the regulating and controlling solution flushing pressure of the voltage stabilizing system, and then the flushing liquid enters the multistage serial sample bin to realize a flushing test of a coating sample in the sample bin; the device also comprises a monitoring system, an alarm system, a flushing liquid automatic supplementing system and a computer control system, wherein the flushing liquid automatic supplementing system is used for automatically supplementing flushing liquid in the flushing liquid circulating system, and the monitoring system is used for monitoring the running state of the device and uniformly controlling and managing data by the computer control system.
In the above technical scheme, further, the flushing liquid circulation system comprises a high-pressure water pump, a water tank, a circulation pipeline, a temperature control system and a water level monitoring system; the water tank is used for containing flushing liquid, the temperature control system is used for controlling the temperature of the flushing liquid in the water tank to simulate the body fluid temperature, the water level monitoring system is used for monitoring the water level in the water tank, and when the water level is lower than a set water level, the flushing liquid automatic supplementing system is started to supplement the flushing liquid; the high-pressure water pump is used for outputting flushing liquid from the water tank to the filtering system.
Further, the high-pressure water pump is an acid and alkali corrosion resistant pump, and comprises one or more of a centrifugal magnetic pump, a jet pump and the like; the water tank is made of anti-rust materials, and is one or more of stainless steel, PMMA (polymethyl methacrylate) and the like, and the circulating pipeline is one or more of stainless steel, PVC (polyvinyl chloride) and PMMA; the flushing fluid is one or more of PBS, SBF, etc., and the flow rate of the flushing fluid is controlled to be 3-8m 3 The temperature is 37 ℃ and the water level line is controlled to be not lower than 2/3 of the total capacity of the water tank.
Further, the filtering system comprises a tank body, a liquid discharge valve is arranged at the bottom of the tank body, an exhaust valve and a pressure gauge are arranged at the top of the tank body, a water inlet is arranged at the lower side of the tank body and used for inputting flushing liquid, and a water outlet is arranged at the upper side of the tank body and used for outputting the flushing liquid to the pressure stabilizing system; a polycarbonate filter membrane filter plate and a hollow fiber membrane filter device for filtering by using a hollow fiber membrane with an average pore diameter of 0.01-1 μm are sequentially arranged in the tank body from bottom to top, and a PTFE or PP filter core with an average pore diameter of 0.5 μm is arranged.
Further, the pressure stabilizing system comprises a liquid storage, a pressure sensor, a pneumatic control valve and a regulating valve, wherein a water inlet is formed in the lower side of the liquid storage and used for inputting flushing liquid, a water outlet is formed in the upper side of the liquid storage and used for outputting flushing liquid to a multistage serial sample bin, the pressure sensor is used for monitoring the pressure in the liquid storage and is connected with the computer control system through a communication interface, the pneumatic control valve is connected with the regulating valve and installed in the liquid storage, and a pressure gauge is arranged on the liquid storage.
Further, the multi-stage serial sample bins are formed by connecting 2 or more sample bins in series through flanges, each sample bin is made of transparent materials, two ends of each sample bin are integrally formed flanges, and sealing rings are arranged between the flanges of the sample bins connected in series; a sample platform is arranged in the sample bin, a plurality of clamps are arranged on the sample platform and used for placing and fixing samples, and the angle of the samples can be adjusted; and the tail ends of the multistage serial sample bins reflux the flushing liquid to the flushing liquid circulating system through pipelines.
Furthermore, if a sample platform base is arranged in the sample bin, through holes are uniformly distributed on the sample platform base to reduce solution scouring resistance and turbulent flow.
A method of mechanical flush testing of an antimicrobial coated implant, based on the implementation of the apparatus described above, the method comprising: fixing a tested sample on a sample table of a sample bin according to a set flushing angle, starting a computer control system, sequentially setting the temperature, pressure, flow rate and flow rate of flushing liquid, performing state self-checking on the device after the flushing liquid reaches the temperature, automatically starting a high-pressure water pump by the device, filtering and stabilizing the flushing liquid, and then entering the sample bin for a flushing test; the flushing liquid is supplemented by a flushing liquid automatic supplementing system in the test process; when the monitoring system monitors abnormal temperature, pressure or flow of the flushing liquid, the computer control system controls the temperature control system, the pressure stabilizing system and the high-pressure water pump to realize automatic adjustment, and if the automatic adjustment fails, the alarm system is started to give an alarm, and the device automatically pauses operation.
Further, the internal filter element needs to be replaced when the pressure in the filtration system is >2 MPa.
Compared with the prior art, the invention has the following advantages:
1) The invention designs an antimicrobial coating internal implant mechanical scouring experiment device capable of simulating the flowing state of body fluid and an experiment method thereof. The device is characterized in that a flushing loop is formed by arranging a flushing liquid circulating system, a filtering system, a pressure stabilizing system and a sample bin in series, a monitoring system, an alarm system and a flushing liquid automatic supplementing system are connected into a flushing main loop in parallel, so that simulation of an antibacterial coating instrument in the human body environment and simulation detection of coating stability are realized.
2) In the implant mechanical scouring experiment device in the antibacterial coating, PBS/SBF solution is used as scouring liquid, the temperature of the scouring liquid is controlled to be about 37 ℃, and the flow is 3-8m 3 The time period of time is/are set,
the flushing fluid circulation system is responsible for closed loop circulation of flushing fluid, the pressure stabilizing system regulates and controls water pressure, and the filtering system ensures the water quality of the flushing fluid; the monitoring system, the alarm system and the flushing liquid automatic supplementing system are combined to ensure that the device stably runs or alarms when accidents occur. The cooperation of the modules and the technologies ensures the simulation of the scouring state of the body fluid in the human body, and is an innovation of the invention.
3) The sample bins are designed in a multistage series connection mode, are detachable, and can be freely adjusted according to the sample quantity requirement and the power of the pump; each sample bin is internally provided with 1 sample table, and a plurality of clamps are arranged on the sample tables and used for placing and fixing samples; the bottom of the clamp is movably connected with the sample table, the free adjustment of the sample flushing angle can be realized by changing the angle of the clamp, the flushing forces of samples with different angles and directions are tested, and the base of the sample table is provided with a through hole so as to reduce the solution flushing resistance and turbulent flow. The design of the sample bin is matched with other systems of the flushing device, so that the accurate control and simulation of conditions such as body fluid impact rate, impact pressure, impact angle and the like possibly applied to an antibacterial coating sample in vivo are perfectly realized, the use working condition of the antibacterial coating product is truly reproduced, and the finally obtained stability result has practical credibility.
4) The invention relates to an implant mechanical scouring experiment device in an antibacterial coating, which is a full-automatic detection device, wherein a computer system realizes automatic control of each system of the device, and the automatic control from automatic operation of a scouring liquid circulation system, a pressure stabilizing system and a filtering system at the beginning to automatic monitoring and special condition automatic correction of a monitoring system, an alarm system and a scouring liquid automatic supplementing system. From the main device (serial part) to the auxiliary device (parallel part), the full-automatic control system ensures the stable running of the whole device and the accuracy and the authenticity of data.
Drawings
FIG. 1 is a schematic diagram of an experimental device for mechanical washout of an implant in an antimicrobial coating, which can simulate the flow state of body fluid.
FIG. 2 is a schematic diagram showing the structure of a sample chamber, a sample stage and a clamp of an antimicrobial coating internal implant mechanical scouring experiment device capable of simulating the flow state of body fluid; the figure only shows a part of the representative sample stage structure, but also can adopt other similar structures such as a triangle sample stage, a square sample stage and the like, the shape of the clip also only shows a part of the shape, and clips with other shapes such as a spring piece, a needle-punched clip and the like can also be adopted.
In the figure: 1 heating source, 2PID temperature control system, 3 temperature sensor, 4 water inlet, 5 solenoid valve, 6 liquid level supplementing system, 7 discharge valve, 8 filtration system, 9 high-pressure water pump, 10 manometer, 11 flowmeter, 12 ~ 14 sample bin 1 ~ 3, 15PLC converter, 16 pressure control system, 17 computer control system, 18 drain valve, 19 manometer, 20 sample platform.
Detailed Description
The technical scheme of the invention is further described in detail below with reference to the accompanying drawings and specific examples.
The invention relates to an antibacterial coating implant medical instrument simulating body fluid scouring experimental device capable of simulating body fluid flowing state, which structurally comprises: the flushing liquid circulating system, the filtering system, the pressure stabilizing system and the sample bin are sequentially connected in series to form a flushing main loop, and the monitoring system, the alarm system and the flushing liquid automatic supplementing system are connected into the flushing main loop in parallel and are uniformly controlled and data managed by the computer control system; according to an embodiment of the present invention, a specific device structure may be shown in fig. 1.
In the device, the flushing liquid circulating system comprises a high-pressure water pump, a water tank, a circulating pipeline and other parts. The high-pressure water pump is an acid and alkali corrosion resistant pump and comprises one or more of a centrifugal magnetic pump, a jet pump and the like; the volume of the water tank is 50-100L, the water tank is made of a rust-resistant material and is one or more of stainless steel, PMMA (polymethyl methacrylate) and the like, the water tank is provided with scale marks and observation windows, the water tank can be used for manually observing the water level and the water quality, and meanwhile, a temperature control system, a water level monitoring system and an automatic flushing liquid supplementing system are arranged in the water tank; diameter of circulation line
The inner diameter and the wall thickness are 2-10mm, and the material is one or more of stainless steel, PVC and PMMA. The bottom of the water tank is provided with a valve with a threaded hole, an out-of-band screw pipeline is connected with the water tank, and the other side of the pipeline is connected with the water inlet of the high-pressure water pump. Punching machineThe brushing liquid is one or more of PBS, SBF, etc., and the flow rate of the flushing liquid is controlled to be 3-8m 3 The temperature is 37 ℃ and the water level line is not lower than 2/3 of the total capacity of the water tank, so that the solution can be heated in time, and the body fluid state simulation is realized.
The shell of the filtering system is made of one or more of stainless steel or PP materials, the filter is fastened by a tank body and an upper cover through an O-shaped rubber sealing ring by a pressing plate, a pressure gauge is arranged on the upper cover by opening a screw thread, and an exhaust valve is arranged on the top of the upper cover; the bottom of the tank body is provided with a liquid discharge valve, the lower side of the tank body is provided with a water inlet, and the upper side of the tank body is provided with a water outlet; the inside is from bottom to top in turn 1 filter plate with polycarbonate filter membrane, 1 hollow fiber membrane filter device for filtering by 1 hollow fiber membrane with average pore size of 0.01 μm-1 μm, 1 10 inch 0.5 μm PTFE or PP filter core.
The pressure stabilizing system mainly comprises a pneumatic control valve, a regulating valve, a pressure sensor, a pressure gauge, a controller and a liquid storage. The pressure sensor signal is connected with the computer control system through the communication interface, the pneumatic control valve is connected with the regulating valve and is installed in the liquid reservoir, the pressure gauge is arranged above the liquid reservoir and is connected with the opening by the screw thread, the upper part and the lower part of the liquid reservoir are respectively provided with a water inlet and a water outlet, the pressure gauge is connected with the liquid reservoir by the screw thread, and the volume of the liquid reservoir is at least more than 10L.
The flushing liquid enters a multi-stage serial sample bin after passing through a flowmeter, wherein the multi-stage serial sample bin comprises 2 or more sample bins which are connected in series by flanges, and the sample bins are cylindrical, have the length of 200-500mm and the inner diameter
The wall thickness is 2-20mm, the material is transparent PMMA, flange plates are integrally formed at two ends, a sealing ring is arranged between the flange plates, and the sample bins are detachable, so that the serial number of the sample bins can be freely adjusted according to the number of samples and the power of a pump. Each sample bin is internally provided with 1 sample stage, the sample stage is provided with a plurality of clamps for placing and fixing samples, as shown in fig. 2, two different clamp designs are embodied in the figure, the bottom of each clamp is movably connected with the sample stage, and the samples can be realized by changing the angles of the clampsThe free adjustment of the scouring angle, the testing of the scouring force of the samples with different angles and directions, which is only a specific example of the invention, can be designed by the sample table and the fixture in practice, as long as the sample can be fixed according to the required angle; if a sample table base is provided, the sample table base can be provided with 10-50 +.>
The round holes reduce the solution scouring resistance and turbulent flow. The tail ends of the multistage serial sample bins are connected into a flushing fluid circulating system through pipelines so that the flushing fluid flows back into the water tank.
The monitoring system, the alarm system and the flushing liquid automatic supplementing system together complete automatic control and information monitoring of the device. A water supplementing inlet and a liquid level sensor are arranged in a water tank of the flushing liquid circulating system, signals of the liquid level sensor are transmitted to a computer through a data interface, and the computer data interface is connected with a PLC control electromagnetic valve. When the low water level is monitored, the automatic water replenishing controller controls the electromagnetic valve to be opened, and the water inlet pipe is used for replenishing liquid from the spare water tank to the water tank for device testing; when the liquid level sensor detects a high water level, the electromagnetic valve is closed, and water supplementing is stopped. The temperature control system is arranged in the water tank and consists of a PID temperature controller, a Pt100 thermocouple, a relay and a Teflon heater, wherein Pt100 measures the temperature data of flushing liquid and transmits the temperature data to the PID controller, and the on-off of the heater is controlled by the relay to reach the set test temperature. The hardware system is connected with a computer control software system, and the computer control software system is characterized in that a DCS distributed control system based on an Ethernet is adopted, a lower computer adopts a PLC, an upper computer hardware platform adopts a special industrial personal computer, and a software platform adopts a professional measurement and control software platform for development. The lower computer PLC is responsible for completing the collection of all test sensor signals, the switching of the pressure test flow, the collection of test pressure, the judgment of abnormal conditions and the like. The upper computer software inputs instructions such as test standards, test processes, test parameters and the like to the lower computer through the communication interface, meanwhile, the upper computer software can also acquire parameters such as test pressure, test flow state and the like to the lower computer, can display and save test data in real time, and can automatically terminate the operation of the device and alarm when faults occur.
The method for carrying out the body fluid scouring simulation test of the medical device with the antibacterial coating implant comprises the following steps:
1. fixing a tested sample on a sample table of a sample bin according to a set flushing angle, starting a computer control system and software, and setting the temperature, pressure, flow rate and flow of flushing liquid on a control panel in sequence;
2. after the flushing liquid reaches the set temperature, the flushing device performs state self-checking; after the self-checking is finished, the device automatically starts the high-pressure water pump to start a scouring test. In the test process, the flushing liquid is pumped into a circulating pipeline by a high-pressure water pump, impurities are removed by a filtering system, the flushing liquid enters a pressure stabilizing system to enable the water pressure to reach a set value, then the flushing liquid sequentially enters sample bins connected in series, the surfaces of samples of the antibacterial coating are flushed, and finally the flushing liquid returns to the water tank again to continue the next circulation;
3. meanwhile, under the control of computer software, a monitoring system, an alarm system and an automatic flushing liquid supplementing system monitor the running state (including water pressure, water temperature, water level and flow rate/flow rate) of the device in real time; the voltage stabilizing system, the temperature control system, the flushing liquid automatic supplementing system and the like maintain the flushing process in real time, and keep the parameters within the error range; once the parameters are abnormal, the alarm system immediately gives an alarm, and the computer sends alarm information to the mobile phone of the responsible person through the wireless network, and meanwhile, the device is subjected to emergency shutdown treatment and waits for maintenance. And when the filtration pressure is >2MPa the system will prompt replacement of the cartridge.
Claims (9)
1. An antimicrobial coated endoimplant mechanical flush test device capable of simulating the flow state of body fluid, the device comprising: the system comprises a flushing liquid circulation system, a filtering system, a voltage stabilizing system and a multistage serial sample bin which are sequentially connected in series to form a flushing loop, wherein flushing liquid simulating body fluid is output through the flushing liquid circulation system, filtered through the filtering system, and the flushing state of the body fluid is simulated through the regulating and controlling solution flushing pressure of the voltage stabilizing system, and then the flushing liquid enters the multistage serial sample bin to realize a flushing test on a coating sample fixed in the sample bin; the device also comprises a monitoring system, an alarm system, a flushing liquid automatic supplementing system and a computer control system, wherein the flushing liquid automatic supplementing system is used for automatically supplementing flushing liquid in the flushing liquid circulating system, and the monitoring system is used for monitoring the running state of the device and uniformly controlling and managing data by the computer control system.
2. The device for simulating the antibacterial coating mechanical scouring experiment of the body fluid flowing state according to claim 1, wherein the scouring fluid circulation system comprises a high-pressure water pump, a water tank and a circulation pipeline, and further comprises a temperature control system and a water level monitoring system; the water tank is used for containing flushing liquid, the temperature control system is used for controlling the temperature of the flushing liquid in the water tank to simulate the body fluid temperature, the water level monitoring system is used for monitoring the water level in the water tank, and when the water level is lower than a set water level, the flushing liquid automatic supplementing system is started to supplement the flushing liquid; the high-pressure water pump is used for outputting flushing liquid from the water tank to the filtering system.
3. The device for performing an antimicrobial coating endoprosthesis scouring experiment according to claim 2, wherein the high-pressure water pump is an acid and alkali corrosion resistant pump, the water tank is made of an anti-rust material, the scouring fluid is PBS or SBF solution, and the flow rate of the scouring fluid is controlled to be 3-8m 3 The temperature is 37 ℃ and the water level line is controlled to be not lower than 2/3 of the total capacity of the water tank.
4. The device for performing an antimicrobial coating internal implant mechanical scouring experiment according to claim 1, wherein the filtering system comprises a tank body, a liquid discharge valve is arranged at the bottom of the tank body, an exhaust valve and a pressure gauge are arranged at the top of the tank body, a water inlet is arranged at the lower side of the tank body for inputting scouring liquid, and a water outlet is arranged at the upper side of the tank body for outputting scouring liquid to a pressure stabilizing system; a polycarbonate filter membrane filter plate and a hollow fiber membrane filter device for filtering by using a hollow fiber membrane with an average pore diameter of 0.01-1 μm are sequentially arranged in the tank body from bottom to top, and a PTFE or PP filter core with an average pore diameter of 0.5 μm is arranged.
5. The device for simulating the flushing experiment of the implant machinery in the antibacterial coating capable of simulating the flowing state of body fluid according to claim 1, wherein the pressure stabilizing system comprises a liquid reservoir, a pressure sensor, a pneumatic control valve and a regulating valve, a water inlet is formed in the lower side of the liquid reservoir and used for inputting flushing liquid, a water outlet is formed in the upper side of the liquid reservoir and used for outputting flushing liquid to a multistage serial sample bin, the pressure sensor is used for monitoring the pressure in the liquid reservoir and is connected with the computer control system through a communication interface, the pneumatic control valve is connected with the regulating valve and installed in the liquid reservoir, and a pressure gauge is arranged on the liquid reservoir.
6. The antimicrobial coating inner implant mechanical scouring experiment device capable of simulating the flow state of body fluid according to claim 1, wherein the multistage serial sample chambers are formed by connecting 2 or more sample chambers in series through flanges, each sample chamber is made of transparent materials, two ends are integrally formed flanges, and sealing rings are arranged between the flanges of the serial sample chambers; a sample platform is arranged in the sample bin, a plurality of clamps are arranged on the sample platform and used for placing and fixing samples, and the angle of the samples can be adjusted; and the tail ends of the multistage serial sample bins reflux the flushing liquid to the flushing liquid circulating system through pipelines.
7. The device for simulating the flow of body fluid of claim 1, wherein if a sample stage base is provided in the sample compartment, holes are uniformly distributed in the sample stage base to reduce the solution scouring resistance and turbulence.
8. A method of flush testing an implant device within an antimicrobial coating, the method comprising: fixing a tested sample on a sample table of a sample bin according to a set flushing angle, starting a computer control system, sequentially setting the temperature, pressure, flow rate and flow rate of flushing liquid, performing state self-checking on the device after the flushing liquid reaches the temperature, automatically starting a high-pressure water pump by the device, filtering and stabilizing the flushing liquid, and then entering the sample bin for a flushing test; the flushing liquid is supplemented by a flushing liquid automatic supplementing system in the test process; when the monitoring system monitors abnormal temperature, pressure or flow of the flushing liquid, the computer control system controls the temperature control system, the pressure stabilizing system and the high-pressure water pump to realize automatic adjustment, and if the automatic adjustment fails, the alarm system is started to give an alarm, and the device automatically pauses operation.
9. The method of claim 8, wherein the internal filter element is replaced when the pressure in the filtration system is greater than 2 MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310313657.2A CN116359122A (en) | 2023-03-28 | 2023-03-28 | Device and method for experimental scouring of implant machinery in antibacterial coating capable of simulating body fluid flow state |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310313657.2A CN116359122A (en) | 2023-03-28 | 2023-03-28 | Device and method for experimental scouring of implant machinery in antibacterial coating capable of simulating body fluid flow state |
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| CN116359122A true CN116359122A (en) | 2023-06-30 |
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| CN202310313657.2A Pending CN116359122A (en) | 2023-03-28 | 2023-03-28 | Device and method for experimental scouring of implant machinery in antibacterial coating capable of simulating body fluid flow state |
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| Country | Link |
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| CN (1) | CN116359122A (en) |
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2023
- 2023-03-28 CN CN202310313657.2A patent/CN116359122A/en active Pending
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