CN116350879A

CN116350879A - Circuit shell integrated drug infusion device and artificial pancreas thereof

Info

Publication number: CN116350879A
Application number: CN202111622026.6A
Authority: CN
Inventors: 杨翠军
Original assignee: Medtrum Technologies Inc
Current assignee: Medtrum Technologies Inc
Priority date: 2021-12-28
Filing date: 2021-12-28
Publication date: 2023-06-30

Abstract

The invention discloses a circuit shell integrated drug infusion device and an artificial pancreas thereof, comprising: a cartridge for containing the medicament, the cartridge having a piston and a screw disposed therein; the driving wheel is connected with the screw rod and drives the piston to advance by rotating the driving screw rod; a power supply for powering the infusion device; the shell comprises an upper shell and a lower shell, and is used for accommodating the medicine storage cylinder, the driving wheel and the power supply, and a three-dimensional circuit is further arranged on the shell and is electrically connected with the power supply to supply power to the infusion device. The three-dimensional circuit is arranged on the shell, so that the internal space of the infusion device is not occupied, the internal structure of the infusion device is more compact, and the volume of the infusion device is further smaller.

Description

Circuit shell integrated drug infusion device and artificial pancreas thereof

Technical Field

The invention mainly relates to the field of medical equipment, in particular to a circuit shell integrated drug infusion device and an artificial pancreas thereof.

Background

The pancreas in the body of a normal person can automatically monitor the glucose content in the blood of the person and automatically secrete the required insulin/glucagon. However, the pancreas of the diabetic patient has abnormal functions and cannot normally secrete insulin required by the human body. Diabetes is a metabolic disease caused by abnormal pancreatic function of a human body, and diabetes is a life-long disease. At present, the medical technology cannot radically cure diabetes, and the occurrence and development of diabetes and complications thereof can only be controlled by stabilizing blood sugar.

Diabetics need to test blood glucose before injecting insulin into the body. Most of the current detection methods can continuously detect blood sugar and send blood sugar data to remote equipment in real time, so that the blood sugar data is convenient for a user to check, and the detection method is called continuous glucose detection (Continuous Glucose Monitoring, CGM). The method needs to attach the detection device to the skin surface, and the probe carried by the detection device is penetrated into subcutaneous tissue fluid to complete detection. According to the blood glucose value detected by CGM, the infusion device inputs the insulin required currently into the skin, thereby forming a closed loop or semi-artificial pancreas.

The prior infusion device has low utilization rate of internal space and compact structure, so that the volume of the infusion device is relatively large.

Accordingly, there is a need in the art for a drug infusion device that is more compact in internal structure and less bulky.

Disclosure of Invention

The invention discloses a circuit and shell integrated drug infusion device, wherein a three-dimensional circuit is arranged on a shell, so that the internal space of the infusion device is not occupied, the internal structure of the infusion device can be more compact, and the volume of the infusion device is further smaller.

The invention discloses a circuit shell integrated drug infusion device, which comprises: a cartridge for containing the medicament, the cartridge having a piston and a screw disposed therein; the driving wheel is connected with the screw rod and drives the piston to advance by rotating the driving screw rod; a power supply for powering the infusion device; the shell comprises an upper shell and a lower shell, and is used for accommodating the medicine storage cylinder, the driving wheel and the power supply, and a three-dimensional circuit is further arranged on the shell and is electrically connected with the power supply to supply power to the infusion device.

According to one aspect of the invention, the stereoscopic circuit is coated on the upper and/or lower housing.

According to one aspect of the invention, the stereoscopic circuit is embedded in the upper and/or lower housing.

According to one aspect of the invention, the stereoscopic circuit is integrally formed with the upper and/or lower housings by injection molding.

According to one aspect of the invention, the upper shell and/or the lower shell are/is provided with grooves, and the stereoscopic circuit is embedded into the upper shell and/or the lower shell through the grooves.

According to one aspect of the invention, the power supply comprises a power supply housing, a battery cell, an electrolyte and a cover plate, the infusion device further comprising a main frame, the main frame being of unitary construction with the power supply housing and/or the cover plate being of unitary construction with the upper housing or the lower housing.

According to one aspect of the invention, the power supply housing and the inside of the cover plate are provided with electrolyte barrier layers.

According to one aspect of the invention, the electrolyte barrier is coated TPE or PET.

According to one aspect of the invention, the electrolyte barrier layer is a separate layer of TPE or PET material.

According to one aspect of the invention, the connection of the power supply housing and the cover plate is coated with an insulating sealing material.

According to one aspect of the invention, the insulating sealing material is a hot melt adhesive or a silicone gel.

According to one aspect of the invention, an infusion device includes an infusion structure and a control structure, a cartridge, a drive wheel and a power source are disposed on the infusion structure.

According to one aspect of the invention, the infusion structure and the control structure are split structures, and the control structure can be reused.

According to one aspect of the invention, the infusion structure and the control structure are a unitary structure that is discarded entirely after use.

The invention discloses an artificial pancreas, which comprises a circuit shell integrated drug infusion device and a detection structure, wherein the detection structure is used for continuously detecting blood glucose level parameters and is connected with or integrated with a control structure and an infusion structure of the infusion device.

According to one aspect of the invention, two of the detecting structure, the control structure and the infusion structure are connected or integrated to form a single structure and are adhered to different positions of the skin with the third structure

According to one aspect of the invention, the detection structure, the control structure and the infusion structure are connected or integrated into a single structure and are adhered to the same location of the skin.

Compared with the prior art, the technical scheme of the invention has the following advantages:

in the circuit-shell integrated drug infusion device disclosed by the invention, the three-dimensional circuit is arranged on the shell, so that the internal space of the infusion device is not occupied, the main frame is not needed to bear the circuit module, the internal structure of the infusion device can be more compact, and the volume of the infusion device is smaller.

Furthermore, the three-dimensional circuit is embedded in the upper shell and/or the lower shell, so that the volume of the infusion device is further reduced.

Further, the main frame and the power supply shell are of an integrated structure and/or the cover plate and the upper shell or the lower shell are of an integrated structure, the shape and the size of the power supply are not limited by the shape and the size of the button battery shell, an independent shell is not needed any more, the occupied volume is small, more active substances can be put in the battery, and the battery capacity is increased.

Furthermore, the electrolyte insulating layer is made of TPE or PET, so that the electrolyte can be effectively prevented from corroding the power supply shell and the cover plate.

Further, the power supply shell is coated with hot melt adhesive, so that on one hand, electrolyte leakage can be prevented; on the other hand, helps in self thermal runaway management of the power supply.

Drawings

FIGS. 1 a-1 b are top views of drug infusion systems according to two different embodiments of the present invention;

FIG. 2a is a schematic perspective view of an infusion structure according to one embodiment of the present invention;

FIG. 2b is a schematic cross-sectional view of a power supply in the Y-Y' direction according to an embodiment of the present invention;

FIG. 2c is a schematic perspective view of an infusion structure from another perspective in accordance with an embodiment of the present invention;

FIG. 3a is a schematic perspective view of an infusion structure according to yet another embodiment of the present invention;

FIG. 3b is a schematic cross-sectional view of a power supply in the Y-Y' direction according to an embodiment of the present invention;

FIG. 3c is a schematic perspective view of another view infusion structure according to an embodiment of the present invention;

FIG. 4 is a schematic diagram of artificial pancreas module relationships according to an embodiment of the invention.

Detailed Description

As described above, the prior art infusion device has a low internal space utilization and a compact structure, which makes the infusion device relatively bulky.

In order to solve the problem, the invention provides a drug infusion device, a three-dimensional circuit is arranged on a shell, the internal space of the infusion device is not occupied, a main frame is not needed to bear a circuit module, the internal structure of the infusion device can be more compact, and the volume of the infusion device is smaller.

Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be understood that the relative arrangement of parts and steps, numerical expressions and numerical values set forth in these embodiments should not be construed as limiting the scope of the present invention unless it is specifically stated otherwise.

Furthermore, it should be understood that the dimensions of the various elements shown in the figures are not necessarily drawn to actual scale, e.g., the thickness, width, length, or distance of some elements may be exaggerated relative to other structures for ease of description.

The following description of the exemplary embodiment(s) is merely illustrative, and is in no way intended to limit the invention, its application, or uses. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail herein, but where applicable, should be considered part of the present specification.

It should be noted that like reference numerals and letters refer to like items in the following figures, and thus once an item is defined or illustrated in one figure, no further discussion thereof will be necessary in the following figure description.

Fig. 1 a-1 b are top views of drug infusion devices according to two different embodiments of the present invention.

The integrated drug infusion device of the circuit housing of the embodiment of the invention comprises two parts: a control structure 100, an infusion structure 110, and an adhesive patch 120. These structures will be described separately below. In other embodiments of the present invention, the circuit housing integrated drug infusion device may also include additional components, without limitation.

The patch type drug infusion device refers to an infusion device without a long catheter, and the infusion device is integrally adhered to the skin surface of a user by the same patch 120, and further comprises an infusion needle unit 130 integrated on the drug infusion device instead of the long catheter, so that the drug can be directly infused from the drug storage cartridge to the subcutaneous side along the infusion needle by the infusion needle unit 130 in the device.

The circuit housing integrated drug infusion device of the embodiment of the invention includes a control structure 100. The control structure 100 is configured to receive signals or information from a remote device or a body fluid parameter testing device (e.g., a continuous blood glucose testing device) and to control the infusion device to complete the drug infusion. The housing of the control structure 100 is provided with a program module, a circuit board, and related electronic components for receiving signals or sending control instructions, and other physical components or structures necessary for implementing the infusion function, and the like, which are not particularly limited herein. In some embodiments of the invention, a power supply is also provided in the control structure. In an embodiment of the present invention, a power source 113 is provided in the infusion structure 110, as described below.

The circuit housing integrated drug infusion device also includes an infusion structure 110. The interior of the housing is provided with an infusion module, a circuit module and other auxiliary modules for accomplishing drug infusion, as will be described in detail below. The housing of the infusion structure 110 may include multiple parts. As in the present embodiment, the housing of the infusion device includes an upper housing 111a and a lower housing 111b.

In the embodiment of the present invention, the control structure 100 and the infusion structure 110 are of a split design, and are connected or directly clamped and electrically connected as a whole through a waterproof plug. The control structure 100 and the infusion structure 110 may improve the reliability of the electrical connection when they are directly snapped and electrically connected as a unit. The control structure 100 may be reusable and the infusion structure 110 may be disposable after a single use, as shown in fig. 1 a. In another embodiment of the present invention, the infusion structure 110 and the control structure 100 are integrally designed, and are connected by a wire, and disposed inside the same housing 10, and are adhered to a certain position of the skin of the user by an adhesive patch 120, and then are discarded integrally after a single use, as shown in fig. 1b.

The infusion structure 110 of the embodiment of the present invention is further provided with an infusion needle unit 130 for infusing a drug subcutaneously.

The bottom of the lower housing 111b of the infusion structure 110 is further provided with an adhesive patch 120 for adhering the infusion device to the skin surface of a user.

Fig. 2a is a schematic perspective view of an infusion structure 110 according to an embodiment of the present invention; FIG. 2b is a schematic cross-sectional view of the power supply 113 in the Y-Y' direction according to an embodiment of the present invention; fig. 2c is a schematic perspective view of an infusion structure 110 from another perspective according to an embodiment of the present invention.

In an embodiment of the present invention, the infusion structure 110 comprises mechanical units, electronic control units, etc. for performing infusion functions, such as a cartridge 112, a power source 113, a drive wheel 114, a main frame 115, a stereo circuit 116, and a drive unit (not shown), etc. The main frame 115 is used to carry at least the drive wheel 114 and the drive unit. Movement of the drive unit rotates the drive wheel 114, which in turn drives a screw (not shown) to move a piston (not shown) in the cartridge 112, effecting infusion of the drug.

In the embodiment of the present invention, the power supply 113 includes a power supply housing 1131, a battery core 1132, an electrolyte 1133 and a cover plate 1134, the electrolyte 1133 is injected from an opening of the housing 1131 after the battery core 1132 is placed in the power supply housing 1131, then the cover plate 1134 is covered, and an insulating sealing material is coated at a connection part between the cover plate 1134 and the housing 1131, and in the embodiment of the present invention, the insulating sealing material is a hot melt adhesive or a silica gel. Preferably, the insulating sealing material is a hot melt adhesive, which can prevent leakage of electrolyte on the one hand and can help self-thermal runaway management of the power supply 113 on the other hand. In another embodiment of the present invention, sealing may be performed by other means, such as adding a gasket at the cover plate 1134, and the specific sealing manner is not particularly limited herein, so long as sealing of the power supply 113 can be achieved, and leakage of the electrolyte is prevented.

In the embodiment of the present invention, the power supply housing 1131 and the lower housing 111b of the infusion device are integrally formed, the lower housing 111b is a conventional plastic member, such as PE (polyethylene), PP (polypropylene), PC (polycarbonate), and is easily corroded by electrolyte, so that the inner surface thereof is coated with an electrolyte insulation layer 1135, such as a sprayed PET (polyethylene terephthalate) or TPE (butyl rubber) material, and the PET and TPE are electrolyte corrosion resistant materials, which can effectively insulate the battery housing 1131 and the circuit device from damage by the electrolyte, and have a thickness of 300 μm to 500 μm, and if the thickness of the PET film is too small, the electrolyte is soaked and softened by the electrolyte, and if the electrolyte is small, although the PET film is not dissolved and permeated, the insulation effect is still present, too long time may cause the device to age. Excessive thickness can increase the weight and bulk of the power supply housing 1131, which is detrimental to the miniaturized design of the infusion device.

In another embodiment of the present invention, the power supply housing 1131 may also adopt a layered structure, that is, the inner layer and the outer layer are made of different materials, the outer layer is made of common plastics, such as PE, PP, PC, etc., the inner layer is made of TPE (butyl rubber) or PET (polyethylene terephthalate) material, and the TPE is made of thermoplastic elastomer material, which has strong processability and can prevent electrolyte corrosion; PET itself can be used as a container for electrolyte, can resist electrolyte corrosion, and can effectively isolate damage of electrolyte to the power supply housing 1131 and circuit devices.

Likewise, an electrolyte insulating layer 1135 is also disposed on the inner side of the power cover plate 1134, and preferably, the electrolyte insulating layer 1135 on the inner side of the power cover plate 1134 is disposed in a manner consistent with the power housing 1131.

In another embodiment of the present invention, the power cover 1134 is integrally formed with the upper housing 111a of the infusion device, and the upper housing 111a of the infusion device is made of conventional plastic, such as PE (polyethylene), PP (polypropylene), PC (polycarbonate), and is easily corroded by the electrolyte, so that the inner surface thereof is coated with an electrolyte insulation layer 1135, such as a sprayed PET or TPE material, or a layered PET or TPE material layer.

It should be noted that, in the embodiment of the present invention, the "upper housing" and the "lower housing" are merely opposite concepts, that is, the power housing 1131 may be further integrated with the upper housing 111a, and the power cover 1134 may be further integrated with the lower housing 111b.

In the embodiment of the present invention, the power supply housing 1131 and the lower housing 111b, the battery cover 1134 and the upper housing 111a may be integrated at the same time, or may be integrated respectively. When integrally formed, for example, when the power supply housing 1131 and the lower housing 111b are integrally formed, the cover 1134 is independent of the upper housing 111a; when the cover plate 1134 and the upper case 111a are integrally constructed, the power supply case 1131 may be independent of the lower case 111b. When the power supply housing 1131 and the lower housing 111b and the battery cover 1134 and the upper housing 111a may be integrally formed, before the battery cover 1134 covers the power supply housing 1131, an insulating sealing material such as a hot melt adhesive may be coated on the connection portion of the battery cover 1134 located inside the infusion device and the power supply housing 1131, and after the battery cover 1134 covers the power supply housing 1131, the hot melt adhesive may be applied to seal the battery cover 1134 and the power supply housing 1131 by an external heating means such as infrared heating or ultraviolet heating. The connection to the battery cover 1134, which is external to the infusion device, to the power supply housing 1131 may be coated with an insulating sealing material after the battery cover 1134 is covered by the power supply housing 1131.

In an embodiment of the present invention, electrolyte 1133 is one of ethylene carbonate, propylene carbonate, diethyl carbonate, dimethyl carbonate, methylethyl carbonate, lithium hexafluorophosphate, phosphorus pentafluoride, or hydrofluoric acid.

In the embodiment of the present invention, the material of the membrane 11323 is PE (polyethylene) or PP (polypropylene), which may be a single layer PE or PP, or may be 3 layers PE or PP.

In the embodiment of the present invention, the battery core 1132 is a coiled battery core or a laminated battery core, the specific structure of the battery core may be selected according to the shape of the power supply housing 1131, when the power supply housing 1131 is cylindrical, the battery core is a coiled battery core, when the power supply housing 1131 is square, the battery core is a square laminated battery core, when the power supply housing 1131 is in other special-shaped shapes, the battery core may be a special-shaped battery core correspondingly, and the special-shaped battery core is not particularly limited herein, so long as the internal space of the power supply housing 1131 can be fully utilized, electrode active materials are filled to the greatest extent, and the battery capacity is improved, so that the electric quantity of the power supply 113 is increased compared with that of a button battery, and the endurance time of the infusion device is increased.

The cell 1132 includes a positive tab 11321, a negative tab 11322, a separator 11323, a positive tab 11324, and a negative tab 11325. One end of the positive electrode tab 11324 is fixedly connected with the positive electrode tab 11321, preferably by soldering or solder paste, and the other end is electrically connected with an external circuit through a small hole provided in the housing 1131, and a specific electrical connection manner will be described in detail below. The openings and the sizes of the small holes are matched with the cross section shape and the size of the positive electrode tab 11324, and meanwhile, insulating sealing materials are coated at the openings, so that the openings are completely sealed, and no electrolyte is permeated. Preferably, the sealing material is a hot melt adhesive that can facilitate self-thermal runaway management of the power supply 113 while ensuring a complete seal.

Similarly, one end of the negative electrode tab 11325 is fixedly connected to the negative electrode tab 11322, preferably by soldering or soldering, and the other end is electrically connected to an external circuit through a small hole provided in the housing 1131, while the opening is coated with a hot melt adhesive.

In another embodiment of the present invention, the positive electrode tab 11324 and the negative electrode tab 11325 may be electrically connected to the outside without through a small hole, but a part of the tabs are reserved on the outer side of the power supply housing 1131 for electrically connecting to the external circuit while the cover plate 1134 is covered, and a sealing material is coated at the connection between the cover plate 1134 and the housing 1131, preferably, the sealing material is a hot melt adhesive.

In the embodiment of the present invention, the material of the positive electrode tab 11324 is aluminum, and the material of the negative electrode tab 11325 is nickel or copper nickel plating.

In the embodiment of the present invention, the positive electrode material on the positive electrode plate 11321 may be manganese dioxide, the corresponding negative electrode material 11322 is other lithium-based materials such as metallic lithium, and in other embodiments of the present invention, the positive electrode material may be lithium-containing compounds such as lithium manganate, lithium cobaltate, lithium iron phosphate, and the corresponding negative electrode material is graphite.

The infusion structure 110 in the embodiment of the present invention is further provided with a stereo circuit 116, which is connected to the positive electrode tab 11324 and the negative electrode tab 11325 respectively to supply power to a specific structural unit. According to the internal structural characteristics of the infusion device, the shape and the position of the three-dimensional circuit 116 can be flexibly designed, so that the internal space of the infusion structure can be fully utilized, and the structure is more compact.

In the embodiment of the present invention, the stereo circuit 116 is disposed on the main frame 115, as shown in fig. 2a, in one embodiment of the present invention, the stereo circuit 116 is a three-dimensional printed circuit coated on the main frame 115, and in another embodiment of the present invention, the stereo circuit 116 is embedded in the main frame 115, for example, a groove for accommodating the stereo circuit 116 is disposed on the main frame 115, the stereo circuit 116 is embedded in the main frame 115 through the groove, or the main frame 115 and the stereo circuit 116 are embedded in the main frame 115 through injection molding integrally, so that the volume of the infusion apparatus can be further reduced.

In another embodiment of the present invention, the stereo circuit 116 is disposed on the upper case 111a, as shown in fig. 2c, in one embodiment of the present invention, the stereo circuit 116 is a three-dimensional printed circuit coated on the inner side of the upper case 111a, in another embodiment of the present invention, the stereo circuit is embedded in the upper case 111a, the upper case 111a is provided with a groove for accommodating the stereo circuit 116, the stereo circuit 116 is embedded in the upper case 111a through the groove, or the stereo circuit 116 and the upper case 111a are embedded in the upper case 111a through injection molding. When the stereo circuitry 116 is coated or embedded in the upper housing 111a, the cartridge 112 is directly secured by the housing, the specific manner of securing is not limited herein, and the weight and volume of the infusion set can be substantially reduced without the need for the main frame 115 to carry it. When the stereo circuitry 116 is embedded in the upper housing 111a, the weight and volume of the infusion device may be further reduced.

In another embodiment of the present invention, the stereo circuit 116 may be disposed on the lower housing 111b, or on both the upper housing 111a and the lower housing 111b, in a manner and with advantages consistent with the stereo circuit 116 being disposed on the upper housing 111a, which will not be repeated here. In particular, when the stereoscopic circuit 116 is disposed on both the upper case 111a and the lower case 111b, a part of the stereoscopic circuit 116 is disposed on the upper case 111a and a part of the stereoscopic circuit 116 is disposed on the lower case 111b.

FIG. 3a is a schematic perspective view of an infusion structure 210 according to one embodiment of the present invention; FIG. 3b is a schematic cross-sectional view of the power supply 213 in the Y-Y' direction according to an embodiment of the present invention; fig. 3c is a schematic perspective view of an infusion structure 210 according to another embodiment of the present invention.

In the embodiment of the present invention, the power supply 213 includes a power supply housing 2131, a battery cell 2132, an electrolyte 2133 and a cover plate 2134, the electrolyte 2133 is injected from an opening of the housing 2131 after the battery cell 2132 is placed in the power supply housing 2131, then the cover plate 2134 is covered, and an insulating sealing material is coated at a connection between the cover plate 2134 and the housing 2131, and in the embodiment of the present invention, the insulating sealing material is a hot melt adhesive or a silica gel. Preferably, the insulating sealing material is a hot melt adhesive, which on the one hand prevents leakage of electrolyte and on the other hand facilitates self-thermal runaway management of the power supply 213. In another embodiment of the present invention, sealing may be performed by other means, such as adding a gasket at the cover plate 2134, and the specific sealing manner is not particularly limited herein, so long as sealing of the power supply 213 can be achieved, and leakage of the electrolyte is prevented.

In the embodiment of the present invention, the power supply housing 2131 and the main frame 215 of the infusion device are integrally formed, and the main frame 215 is a conventional plastic member, such as PE (polyethylene), PP (polypropylene), PC (polycarbonate), and is easily corroded by electrolyte, so that the inner side surface of the main frame is coated with an electrolyte insulation layer 2135, such as a sprayed PET (polyethylene terephthalate) or TPE (butyl rubber) material, and the PET and TPE are electrolyte corrosion resistant materials, which can effectively insulate the battery housing 2131 and the circuit device from damage by the electrolyte, and have a thickness of 300 μm to 500 μm, and if the thickness of the PET film is too small, the electrolyte is soaked and softened by the electrolyte, and if the electrolyte is small, the PET film is not dissolved and permeated, and the insulation effect is still present, but the device may be aged for too long time. Excessive thickness can increase the weight and bulk of the power supply housing 2131, which is detrimental to the miniaturized design of the infusion device.

In another embodiment of the present invention, the power supply housing 2131 may also adopt a layered structure, that is, the inner layer and the outer layer are made of different materials, the outer layer is made of common plastics, such as PE, PP, PC, etc., the inner layer is made of TPE (butyl rubber) or PET (polyethylene terephthalate) material, and the TPE is made of thermoplastic elastomer material, which has strong processability and can prevent electrolyte corrosion; PET itself can be used as a container for electrolyte, can resist electrolyte corrosion, and can effectively isolate damage of electrolyte to the power supply housing 2131 and circuit devices.

Similarly, the electrolyte barrier 2135 is also provided on the inner side of the power source cover 2134, and preferably, the electrolyte barrier 2135 on the inner side of the power source cover 2134 is provided in a manner consistent with the power source case 2131.

In another embodiment of the present invention, the power cover 2134 is integrally formed with the upper housing 211a or the lower housing 211b of the infusion device, and the upper housing 211a or the lower housing 211b of the infusion device is made of conventional plastic, such as PE (polyethylene), PP (polypropylene), PC (polycarbonate), and is easily corroded by the electrolyte, so that the inner surface thereof is coated with an electrolyte barrier 2135, such as a sprayed PET or TPE material, or a layered PET or TPE material layer.

In the embodiment of the present invention, the power source housing 2131 and the main frame 215, the battery cover 2134 and the upper housing 211a or the lower housing 211b may be simultaneously formed as a single structure or may be separately formed as a single structure. When integrally formed, for example, when the power supply housing 2131 and the main frame 215 are integrally formed, the cover 21134 is independent of the upper housing 211a or the lower housing 211b; when the cover 2134 and the lower upper housing 211a or the lower housing 211b are integrally formed, the power housing 2131 may be independent of the main frame 215. When the power supply housing 2131 and the main frame 215, the battery cover 2134 and the upper housing 211a or the lower housing 211b are simultaneously formed as a unitary structure, an insulating sealing material such as a hot melt adhesive may be applied to the connection portion of the battery cover 2134 located inside the infusion device to the power supply housing 2131 before the battery cover 2134 is covered on the power supply housing 2131, and after the battery cover 2134 is covered on the power supply housing 2131, the hot melt adhesive may be bonded to complete the sealing of the battery cover 2134 and the power supply housing 2131 by external heating means such as infrared heating or ultraviolet heating. The connection of battery cover 2134 to power supply housing 2131, which is external to the infusion device, may be coated after battery cover 2134 is attached to power supply housing 2131.

In an embodiment of the present invention, electrolyte 2133 is one of ethylene carbonate, propylene carbonate, diethyl carbonate, dimethyl carbonate, methylethyl carbonate, lithium hexafluorophosphate, phosphorus pentafluoride or hydrofluoric acid.

In the embodiment of the present invention, the material of the separator 21323 is PE (polyethylene) or PP (polypropylene), which may be a single layer PE or PP, or may be 3 layers PE or PP.

In the embodiment of the present invention, the battery core 2132 is a winding type battery core or a lamination type battery core, the specific battery core structure can be selected according to the shape of the power supply housing 2131, when the power supply housing 2131 is cylindrical, the battery core is a winding type battery core, when the power supply housing 2131 is square, the battery core is a square lamination type battery core, when the power supply housing 2131 is in other special-shaped shapes, the battery core can be a special-shaped battery core correspondingly, and the special-shaped battery core can be selected, so long as the internal space of the power supply housing 2131 can be fully utilized, electrode active materials can be filled to the greatest extent, the battery capacity can be improved, and therefore, the electric quantity of the power supply 213 can be increased compared with that of a button battery, and the duration of the infusion device can be increased.

Cell 2132 includes positive electrode tab 21321, negative electrode tab 21322, separator 21323, positive electrode tab 21324 and negative electrode tab 21325. One end of the positive electrode tab 21324 is fixedly connected to the positive electrode tab 21321, preferably by soldering or solder paste, and the other end is electrically connected to an external circuit through a small hole provided in the housing 2131, in a manner described in detail below. The openings and the sizes of the small holes are matched with the cross section shape and the size of the positive electrode lug 21324, and meanwhile, insulating sealing materials are coated at the openings, so that the full sealing is ensured, and no electrolyte is permeated. Preferably, the sealing material is a hot melt adhesive that can also facilitate self thermal runaway management of the power supply 213 while ensuring a complete seal.

Similarly, one end of the negative electrode tab 21325 is fixedly connected to the negative electrode tab 21322, preferably by soldering or soldering, and the other end is electrically connected to an external circuit through a small hole provided in the case 2131, and a hot melt adhesive is applied to the opening.

In another embodiment of the present invention, the positive electrode tab 21324 and the negative electrode tab 21325 may be electrically connected to the outside without through a small hole, but a part of the tabs are reserved outside the power supply housing 2131 for electrically connecting to the external circuit while the cover plate 2134 is covered, and a sealing material, preferably a hot melt adhesive, is coated at the connection between the cover plate 2134 and the housing 2131.

In the embodiment of the present invention, the material of the positive electrode tab 21324 is aluminum, and the material of the negative electrode tab 21325 is nickel or copper nickel plating.

In the embodiment of the present invention, the positive electrode material on the positive electrode sheet 21321 may be manganese dioxide, the corresponding negative electrode material 21322 is other lithium-based materials such as metallic lithium, and in other embodiments of the present invention, the positive electrode material may be lithium-containing compounds such as lithium manganate, lithium cobaltate, lithium iron phosphate, and the corresponding negative electrode material is graphite.

A stereoscopic circuit 216 is also disposed in the infusion structure 210 in the embodiment of the present invention, and is connected to the positive electrode tab 21324 and the negative electrode tab 21325, respectively, to supply power to a specific structural unit. Depending on the internal structural features of the infusion device, the shape and position of the stereo circuit 216 may be flexibly designed, and the internal space of the infusion structure may be fully utilized, resulting in a more compact structure. In an embodiment of the present invention, the stereo circuit 216 is disposed on the main frame 215, as shown in fig. 3a, in an embodiment of the present invention, the stereo circuit 216 is a three-dimensional printed circuit coated on the main frame 215, and in another embodiment of the present invention, the stereo circuit 216 is embedded in the main frame 215, for example, a groove for accommodating the stereo circuit 216 is disposed on the main frame 215, the stereo circuit 216 is embedded in the main frame 215 through the groove, or the main frame 215 and the stereo circuit 216 are embedded in the main frame through injection molding integrally, so that the volume of the infusion device can be further reduced.

In another embodiment of the present invention, the stereo circuit 216 is disposed on the upper housing 211a, as shown in fig. 3c, in one embodiment of the present invention, the stereo circuit 216 is a three-dimensional printed circuit coated inside the upper housing 211a, in another embodiment of the present invention, the stereo circuit 216 is embedded in the upper housing 211a, the upper housing 211a is provided with a groove for accommodating the stereo circuit, the stereo circuit 216 is embedded in the upper housing 211a through the groove, or the stereo circuit 216 and the upper housing 211a are embedded in the upper housing 211a through injection molding. When the three-dimensional circuit 216 is coated or embedded in the upper housing 211a, the cartridge 112 is directly secured by the housing, and the specific manner of securing is not limited herein, and the volume and weight occupied by the main frame 215 can be substantially reduced without the need for the main frame 215, thereby reducing the weight and volume of the infusion device.

In another embodiment of the present invention, the stereo circuit 216 may also be disposed on the lower housing 211b, or on both the upper housing 211a and the lower housing 211b, in a manner and for its advantageous effects as described above, which will not be repeated here. In particular, when the stereoscopic circuit 216 is disposed on both the upper case 211a and the lower case 211b, a part of the stereoscopic circuit 216 is disposed on the upper case 211a and a part of the stereoscopic circuit 216 is disposed on the lower case 211 b.

An embodiment of the present invention, an artificial pancreas, comprises the power integrated infusion device of the previous embodiments, further comprising a detection structure 340 coupled to or integrated with the control structure 300 and the infusion structure 310 of the infusion device for continuously detecting real-time blood glucose level parameters of the patient. In the embodiment of the present invention, the detecting structure 340 is a continuous glucose detector, which can detect the blood glucose value in real time, monitor the blood glucose change, and send the real-time blood glucose data to the control structure 300.

The control mechanism 300 is used for controlling the infusion mechanism 310 and the detection mechanism 340, in particular, the control mechanism 300 can receive the blood glucose parameter signal sent by the detection mechanism 340, and is used for controlling the detection process of the detection mechanism 340 and recording the infusion information and the working state of the infusion mechanism 310. For example, when the blood glucose information detected by the detection structure 340 after the end of life is not accurate, the control structure 300 may issue a stop detection instruction to the detection structure 340. For another example, when an infusion structure 310 is occluded with insulin, the control structure 300 may record the occlusion condition in time and provide feedback to the patient to eliminate safety concerns. Thus, the control structure 300 is connected to the detection structure 340 and the infusion structure 310, respectively (here, the connection includes a conventional electrical connection or a wireless connection).

The infusion structure 310 contains the mechanical structure necessary for infusing insulin and is controlled by the control structure 300. Based on the current insulin infusion data from the control structure 300, the infusion structure 310 infuses the currently desired insulin into the patient. At the same time, the infusion structure 310 feeds back the infusion status to the control structure 300 in real time.

Embodiments of the present invention are not limited to the specific locations and connection or integration relationships of the detection structure 340, control structure 300, and infusion structure 310, so long as the foregoing functional conditions are met.

As in one embodiment of the present invention, the control structure 300 and the infusion structure 310 are interconnected or integrated into a single structure, while the detection structure 340 is provided separately in another structure. At this time, the detecting structure 340 and the control structure 300 transmit wireless signals to each other to achieve connection with each other. Thus, the control structure 300 and the infusion structure 310 are adhered to one location of the patient's skin, while the detection structure 340 is adhered to the other location of the patient's skin.

As in yet another embodiment of the present invention, the control structure 300 and the detection structure 340 are interconnected or integrated to form the same device, while the infusion structure 310 is provided separately in another structure. The infusion structure 310 and the control structure 300 transmit wireless signals to each other to effect the connection to each other. Thus, the control structure 300 and the detection structure 340 may be affixed to one location of the patient's skin, while the infusion structure 310 may be affixed to another location of the patient's skin.

As in yet another embodiment of the present invention, the infusion structure 310 and the detection structure 340 are interconnected or integrated to form the same device, while the control structure 300 is provided separately in another structure. The infusion structure 310, the detection structure 340 and the control structure 300 mutually transmit wireless signals to achieve connection with each other. The infusion structure 310 and the detection structure 340 may thus be attached to a certain location of the patient's skin, while the control structure 300 may be attached to other locations of the patient's skin or independent of the user, i.e. not attached to any location of the user's skin.

As in one embodiment of the present invention, the three are connected or integrated to form a unitary structure. Therefore, the three are stuck on the same position of the skin of the patient. The three modules are stuck at the same position, so that the number of the skin sticking devices of a patient is reduced, and the interference of the sticking more devices on the movable extension of the patient is further reduced; meanwhile, the problem of unsmooth wireless communication between the separation devices is effectively solved, and the experience of a patient is further enhanced.

As in yet another embodiment of the present invention, the three are disposed in different configurations, respectively. Therefore, the three are respectively stuck on different positions of the skin of the patient. At this time, the control structure 300 transmits wireless signals to each other with the detection structure 340 and the infusion structure 310, respectively, to achieve the connection with each other.

It should be noted that, the control structure 300 of the embodiment of the present invention also has functions of storing, recording, accessing a database, and the like, and thus, the control structure 300 can be reused. Therefore, not only can the physical condition data of the patient be stored, but also the production cost and the consumption cost of the patient are saved. As described above, when the detection structure 340 or the infusion structure 310 is out of life, the control structure 300 may be separated from the detection structure 340, the infusion structure 310, or both the detection structure 340 and the infusion structure 310.

In general, the detection structure 340, the control structure 300, and the infusion structure 310 have different lifetimes. Therefore, when the three are electrically connected to form the same device, the three can be separated from each other. If one module ends the service life first, the patient can only replace the module, and the other two modules are kept for continuous use.

Here, it should be noted that the control structure 300 according to the embodiment of the present invention may further include a plurality of sub-modules. Depending on the function of the sub-modules, different sub-modules may be respectively arranged in different structures, and are not particularly limited herein, as long as the corresponding functional conditions thereof can be satisfied.

In summary, the invention discloses a circuit-housing integrated drug infusion device and an artificial pancreas thereof, wherein a three-dimensional circuit is arranged on a housing, a main frame is not needed to bear a circuit module, the internal space of the infusion device is not occupied, the internal structure of the infusion device is more compact, the volume of the infusion device and the artificial pancreas thereof is further reduced, and the user experience is improved.

While certain specific embodiments of the invention have been described in detail by way of example, it will be appreciated by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the invention. It will be appreciated by those skilled in the art that modifications may be made to the above embodiments without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.

Claims

1. A circuit housing integrated drug infusion device comprising:

a cartridge for containing a medicament, the cartridge having a piston and a screw disposed therein;

the driving wheel is connected with the screw rod and drives the screw rod to push the piston to advance through rotation;

a power supply for powering the infusion device; and

the shell comprises an upper shell and a lower shell, and is used for accommodating the medicine storage cylinder, the driving wheel and the power supply, and a three-dimensional circuit is further arranged on the shell and electrically connected with the power supply to supply power to the infusion device.

2. The circuit housing integrated drug infusion device of claim 1, wherein the stereoscopic circuit is coated on the upper housing and/or the lower housing.

3. The circuit housing integrated drug infusion device of claim 1, wherein the stereoscopic circuit is embedded in the upper housing and/or the lower housing.

4. A circuit housing integrated drug infusion device as in claim 3, wherein the stereoscopic circuit is integrally molded with the upper housing and/or the lower housing by injection molding.

5. A circuit housing integrated drug infusion device according to claim 3 wherein the upper housing and/or the lower housing are grooved and the stereoscopic circuit is embedded into the upper housing and/or the lower housing through the grooves.

6. The circuit housing integrated drug infusion device of claim 1, wherein the power source comprises a power housing, a battery cell, an electrolyte and a cover plate, the infusion device further comprising a main frame, the main frame being of unitary construction with the power housing and/or the cover plate being of unitary construction with the upper housing or the lower housing.

7. The circuit housing integrated drug infusion device of claim 6, wherein the power housing and the cover plate are provided with electrolyte insulation layers inside.

8. The circuit housing integrated drug infusion device of claim 7, wherein the electrolyte barrier is coated TPE or PET.

9. The circuit housing integrated drug infusion device of claim 7, wherein the electrolyte barrier is a separate layer of TPE or PET material.

10. The integrated circuit housing drug infusion device of claim 6, wherein the junction of the power supply housing and the cover plate is coated with an insulating sealing material.

11. The integrated circuit housing drug infusion device of claim 10, wherein the insulating sealing material is a hot melt adhesive or a silicone gel.

12. The circuit housing integrated drug infusion device of claim 1, wherein the infusion device comprises an infusion structure and a control structure, the cartridge, the drive wheel and the power source being disposed on the infusion structure.

13. The integrated circuit housing drug infusion device of claim 12, wherein the infusion structure and the control structure are a split structure, the control structure being reusable.

14. The integrated circuit housing drug infusion device of claim 12, wherein the infusion structure and the control structure are a unitary structure that is disposable entirely after use.

15. An artificial pancreas comprising a circuit housing integrated drug infusion device according to any of claims 12-14, further comprising a detection structure for continuously detecting blood glucose level parameters, connected to or integrated with the control structure of the infusion device, the infusion structure.

16. The artificial pancreas according to claim 15, wherein two of the detecting means, the control means and the infusion means are connected or integrated to form a single structure and are attached to different locations of the skin with a third structure.

17. The artificial pancreas according to claim 15, wherein the detection structure, the control structure and the infusion structure are connected or integrated into a single structure and adhered to the same location of the skin.