CN116327841A

CN116327841A - A preparation for treating diseases caused by kidney yin deficiency, and its preparation method

Info

Publication number: CN116327841A
Application number: CN202310119938.4A
Authority: CN
Inventors: 王浩; 王浩军; 朱海芝
Original assignee: Henan Kangmantang Pharmaceutical Co ltd
Current assignee: Henan Kangmantang Pharmaceutical Co ltd
Priority date: 2023-02-15
Filing date: 2023-02-15
Publication date: 2023-06-27

Abstract

The invention discloses a preparation for treating symptoms caused by kidney yin deficiency and a preparation method thereof, belonging to the technical field of Chinese herbal medicines. The preparation has effects in nourishing liver and kidney, and regulating yin deficiency of liver and kidney; wherein rehmannia root, red paeony root, acanthopanax root and medlar are monarch drugs, which can nourish liver and kidney and regulate liver and kidney yin deficiency; honeysuckle, dogwood, shizandra berry and angelica are used as ministerial drugs, and have the effects of tonifying liver and kidney, tonifying qi and promoting the production of body fluid; hawthorn, chinese date and dark plum are used as adjuvant drugs for strengthening the middle warmer and replenishing qi, nourishing blood and tranquillizing; the preparation is prepared from Poria, herba Solani Nigri and herba Taraxaci, and has effects in clearing away heat and toxic materials and invigorating spleen. The preparation can be used for treating premature graying of hair, poor energy, hypogonadism, and premature senility. It is also used for treating dizziness, tinnitus, soreness of waist and knees, hectic fever due to bone steaming, night sweat, spermatorrhea, diabetes, tinnitus, deafness, feverish sensation in palms and soles, dry mouth, dry throat, dynamic teeth, pain in heel, dribbling urine, etc.

Description

A preparation for treating diseases caused by kidney yin deficiency, and its preparation method

Technical Field

The invention belongs to the technical field of Chinese herbal medicines, and in particular relates to a preparation for treating symptoms caused by kidney yin deficiency and a preparation method thereof.

Background

In modern society life, most people face more and more pressure, bad diet and life habit, and mental stress caused by work and life are also bigger. The above actions are very liable to cause damage to the liver and kidney, namely "yin deficiency of liver and kidney" in traditional Chinese medicine. The kidney is known as the "congenital origin" by traditional Chinese medicine that kidneys store essence and have the functions of growing, developing, reproducing, and metabolizing water. Kidney deficiency and essence loss are important factors causing viscera dysfunction and disease.

The kidney is the congenital origin, and the kidney yin is the root of yin fluid in the body, so there is the "injury of five zang organs, kidney being the heaviest". The waist is the house of the kidney, the kidney governs bone and produces marrow, the teeth are the rest of the bone, and the deficiency of kidney yin causes the bone marrow to be inadequate, so that soreness and weakness of waist and knees, dizziness and tooth movement are seen; kidneys open into ears, kidney yin is insufficient, and essence cannot bear, so tinnitus and deafness are caused; kidney stores essence, which is the root cause of the storage, kidney yin deficiency, failure of the phase fire to store, and delusions and disturbances of the seminal chamber, so seminal emission is seen; yin deficiency produces internal heat, so that the hot flashes, night sweats, feverish palms and soles, diabetes, dry tongue, dry throat, red tongue with little coating, and deep, thready and rapid pulse. It is also caused by kidney deficiency and delayed osteogenesis.

Western medicines are mainly adopted for treating kidney yin deficiency at present, but most of western medicines can cause accumulation of chemical components in a user body and have toxic and side effects. Also, various health products with no drug effect are used, and the products can not be provided for the components required by the organism; some products belong to formula products, but specific formula products have specific symptoms, and do not provide products for basic symptoms of kidney yin deficiency.

Disclosure of Invention

The invention aims to provide a preparation for treating symptoms caused by kidney yin deficiency, which takes nourishing liver and kidney as a main treatment principle, mainly regulates the symptoms of liver and kidney yin deficiency, and is used for treating premature graying of beard and hair, poor energy, hypogonadism and premature senility weakness. It is also used for treating dizziness, tinnitus, soreness of waist and knees, hectic fever due to bone steaming, night sweat, spermatorrhea, diabetes, tinnitus, deafness, feverish sensation in palms and soles, dry mouth, dry throat, dynamic teeth, pain in heel, dribbling urine, etc.

The invention is realized by the following technical scheme:

the preparation for treating the symptoms caused by deficiency of kidney yin is mainly prepared from the following raw materials in parts by weight:

10-40 parts of rehmannia root, 10-40 parts of red paeony root, 10-40 parts of acanthopanax root, 10-40 parts of medlar, 5-35 parts of honeysuckle, 5-35 parts of dogwood, 5-35 parts of shizandra berry, 5-35 parts of angelica, 3-33 parts of hawthorn, 3-33 parts of jujube, 3-33 parts of dark plum fruit, 3-15 parts of poria cocos, 3-15 parts of black nightshade and 3-15 parts of dandelion.

The formulation of the preparation for treating the symptoms caused by deficiency of kidney yin has the effects of tonifying kidney and liver, and rehmannia root, red paeony root, acanthopanax and medlar are taken as monarch drugs, can nourish liver and kidney, and mainly regulate the symptoms of deficiency of liver and kidney yin; wherein rehmanniae radix, radix Paeoniae Rubra, radix Acanthopanacis Senticosi and fructus Lycii are used as principal drugs, and can nourish liver and kidney, and regulate liver and kidney yin deficiency, with symptoms of soreness of waist and knees, tinnitus, deafness, hectic fever and night sweat; honeysuckle, dogwood, shizandra berry and angelica are used as ministerial drugs, and have the effects of tonifying liver and kidney, tonifying qi and promoting the production of body fluid; hawthorn, chinese date and dark plum are used as adjuvant drugs for strengthening the middle warmer and replenishing qi, nourishing blood and tranquillizing; the preparation is prepared from Poria, herba Solani Nigri and herba Taraxaci, and has effects in clearing away heat and toxic materials and invigorating spleen. The prescription is a famous prescription for nourishing yin and tonifying kidney. All the syndromes are caused by kidney-yin deficiency and flaming up of deficiency fire.

Preferably, the preparation is mainly prepared from the following raw materials in parts by mass:

15-30 parts of rehmannia root, 15-30 parts of red paeony root, 15-30 parts of acanthopanax root, 15-30 parts of medlar, 10-25 parts of honeysuckle flower, 10-25 parts of dogwood, 10-25 parts of shizandra berry, 10-25 parts of angelica, 8-23 parts of hawthorn, 8-23 parts of jujube, 8-23 parts of dark plum fruit, 5-13 parts of poria cocos, 5-13 parts of black nightshade and 5-13 parts of dandelion.

20 parts of rehmannia root, 20 parts of red paeony root, 20 parts of acanthopanax root, 20 parts of medlar, 15 parts of honeysuckle, 15 parts of dogwood, 15 parts of shizandra berry, 15 parts of angelica, 13 parts of hawthorn, 13 parts of Chinese date, 13 parts of dark plum, 8 parts of poria cocos, 8 parts of black nightshade and 8 parts of dandelion.

Rehmannia root, radix rehmanniae, sweet and bitter in taste and slightly cold in nature; it enters heart, liver and kidney meridians. Has effects of nourishing yin, clearing heat, cooling blood and replenishing blood. Is used for treating fever, polydipsia, internal heat, diabetes, bone steaming, fatigue and fever, epidemic febrile disease, hemorrhage, metrorrhagia, hematuria, hematochezia, blood deficiency, sallow complexion, dizziness, palpitation, and amenorrhea due to blood heat.

Red peony root, radix Paeoniae Rubra, bitter in taste and slightly cold in nature; enter liver meridian. Has effects of clearing heat, cooling blood, promoting blood circulation, and removing blood stasis. Is mainly used for treating toxic heat with symptoms of macula, hematemesis, epistaxis, conjunctival congestion, swelling and pain, carbuncle, swelling and sore, liver Yu Xie pain, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain and traumatic injury.

Acanthopanax root is sweet in taste and slightly bitter in nature; it enters spleen, lung, heart and kidney meridians. Has effects of invigorating qi, invigorating spleen, tonifying kidney, and tranquilizing. Is mainly used for treating spleen and lung qi deficiency, kidney deficiency, soreness of waist and knees, heart and spleen deficiency, insomnia, amnesia and the like.

Wolfberry fruit, sweet in taste and neutral in nature; it enters liver, kidney and lung meridians. Has effects of nourishing liver and kidney, and replenishing vital essence. It is indicated for deficiency of liver-yin and kidney-yin and premature senility.

Honeysuckle flower, sweet in taste and cold in nature; enter lung, heart and stomach meridians. Has effects of clearing heat and detoxicating, dispelling pathogenic wind and heat. It is mainly used for treating carbuncle, furuncle, exogenous wind-heat, epidemic febrile disease, and dysentery due to toxic heat and blood.

Cornel is sour and astringent in taste and slightly warm in nature; it enters liver and kidney meridians. Has effects of invigorating liver and kidney, astringing, and inducing astringency. Is mainly used for treating soreness and weakness of waist and knees, dizziness and tinnitus, impotence, spermatorrhea and seminal emission, enuresis and frequent urination, metrorrhagia, menorrhagia, excessive sweating, and asthenia.

Schisandra chinensis, sour and sweet in taste and warm in nature; it enters lung, heart and kidney meridians. Has effects of astringing, invigorating qi, promoting fluid production, invigorating kidney, and calming heart. Is used for treating cough, asthma, spontaneous perspiration, night sweat, spermatorrhea, chronic diarrhea, body fluid deficiency, thirst, diabetes, palpitation, insomnia, and dreaminess.

Dang Gui is sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians. Has effects of replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, loosening bowel, and relieving constipation. Is mainly used for treating blood deficiency and sallow complexion, irregular menstruation, amenorrhea and dysmenorrhea, blood deficiency, blood stagnation, blood cold pain, traumatic injury, rheumatalgia, carbuncle, sore and ulcer, constipation due to intestinal dryness, etc.

Hawthorn fruit, fructus crataegi is sour and sweet in taste and slightly warm in nature; it enters spleen, stomach and liver meridians. Has effects of promoting digestion, resolving food stagnation, activating qi-flowing and removing blood stasis. Is used for treating food stagnation, diarrhea, dysentery, abdominal pain, hernia pain, chest pain due to blood stasis, and dysmenorrhea.

Jujube, sweet in taste and warm in nature; it enters spleen, stomach and heart meridians. Has effects of invigorating spleen and replenishing qi, nourishing blood and tranquillizing. It is indicated for spleen deficiency syndrome, dysphoria and insomnia.

Dark plum, sour and astringent taste and mild nature; it enters liver, spleen and lung meridians. Has effects of astringing lung, relieving cough, relieving diarrhea with astringents, relieving ascarid pain, promoting salivation, and quenching thirst. It is indicated for chronic cough due to lung deficiency, chronic diarrhea, chronic dysentery, ascariasis, abdominal pain, emesis, and deficiency heat diabetes.

Poria, sweet and light in taste, neutral in nature; it enters heart, lung and spleen meridians. Has effects of inducing diuresis to alleviate edema, eliminating dampness, invigorating spleen, and calming heart. Is mainly used for treating edema, phlegm-fluid retention, spleen deficiency diarrhea, palpitation and insomnia.

Solanum nigrum is bitter in flavor and cold in nature. Has effects of clearing heat, detoxicating, promoting blood circulation and detumescence. It is used for treating furuncle, carbuncle, erysipelas, traumatic injury, sprain, cough, and edema.

Dandelion is bitter and sweet in taste and cold in nature; enter liver and stomach meridians. Has effects of clearing heat and detoxicating, detumescence and resolving hard mass, promoting diuresis and treating stranguria. Is mainly used for treating carbuncle, furuncle, acute mastitis, internal carbuncle, heat stranguria, pain, jaundice due to damp-heat, clearing liver and improving eyesight.

A method of preparing a formulation for treating a condition caused by kidney yin deficiency, comprising:

selecting radix rehmanniae, radix paeoniae rubrathe, acanthopanax, medlar, honeysuckle, dogwood, shizandra berry, angelica, hawthorns, chinese dates, dark plums, poria cocos, black nightshade and dandelion according to the corresponding parts by weight, mixing, crushing, adding a solvent and making pills.

Preferably, the crushed materials are sieved by a 5000-8000 mesh sieve.

Preferably, the solvent is water.

Preferably, 20-30g of solvent is added to 100 g of the raw material mixed powder for mixing and pelleting.

Preferably, the formulation is a pill.

Preferably, the weight per gram of the pellets is 0.2-0.3g.

Compared with the prior art, the invention has at least the following technical effects:

the invention provides a preparation for treating symptoms caused by kidney yin deficiency, which takes nourishing liver and kidney as a main treatment rule and mainly regulates the symptoms of liver and kidney yin deficiency; wherein rehmanniae radix, radix Paeoniae Rubra, radix Acanthopanacis Senticosi and fructus Lycii are used as principal drugs, and can nourish liver and kidney, and regulate liver and kidney yin deficiency, with symptoms of soreness of waist and knees, tinnitus, deafness, hectic fever and night sweat; honeysuckle, dogwood, shizandra berry and angelica are used as ministerial drugs, and have the effects of tonifying liver and kidney, tonifying qi and promoting the production of body fluid; hawthorn, chinese date and dark plum are used as adjuvant drugs for strengthening the middle warmer and replenishing qi, nourishing blood and tranquillizing; the preparation is prepared from Poria, herba Solani Nigri and herba Taraxaci, and has effects in clearing away heat and toxic materials and invigorating spleen. The prescription is a famous prescription for nourishing yin and tonifying kidney. All the syndromes are caused by kidney-yin deficiency and flaming up of deficiency fire.

The preparation can be used for treating premature graying of hair, poor energy, hypogonadism, and premature senility. It is also used for treating dizziness, tinnitus, soreness of waist and knees, hectic fever due to bone steaming, night sweat, spermatorrhea, diabetes, tinnitus, deafness, feverish sensation in palms and soles, dry mouth, dry throat, dynamic teeth, pain in heel, dribbling urine, etc.

Drawings

FIG. 1 is a base peak chromatogram in positive ion mode of a test sample.

FIG. 2 shows a basic peak chromatogram in a negative ion mode of a detection sample.

Fig. 3 is a sample detection appearance diagram.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to the following examples, which are to be construed as merely illustrative and not limitative of the scope of the invention, but are not intended to limit the scope of the invention to the specific conditions set forth in the examples, either as conventional or manufacturer-suggested, nor are reagents or apparatus employed to identify manufacturers as conventional products available for commercial purchase.

Example 1

The preparation for treating the symptoms caused by deficiency of kidney yin is prepared from the following raw materials in parts by mass:

100 g of rehmannia root, 100 g of red paeony root, 100 g of acanthopanax root, 100 g of medlar, 50 g of honeysuckle, 50 g of dogwood, 50 g of shizandra berry, 50 g of angelica, 30g of hawthorn, 30g of Chinese date, 30g of dark plum, 30g of poria cocos, 30g of black nightshade and 30g of dandelion.

Example 2

400 g of rehmannia root, 400 g of red paeony root, 400 g of acanthopanax root, 400 g of medlar, 350 g of honeysuckle, 350 g of dogwood, 350 g of shizandra berry, 350 g of angelica, 330 g of hawthorn, 330 g of Chinese date, 330 g of dark plum, 150 g of poria cocos, 150 g of black nightshade and 150 g of dandelion.

Example 3

150 g of rehmannia root, 150 g of red paeony root, 150 g of acanthopanax, 150 g of medlar, 100 g of honeysuckle, 100 g of dogwood, 100 g of shizandra berry, 100 g of angelica, 80 g of hawthorn, 80 g of jujube, 80 g of dark plum, 50 g of poria cocos, 50 g of black nightshade and 50 g of dandelion.

Example 4

300 g of rehmannia root, 300 g of red paeony root, 300 g of acanthopanax root, 300 g of medlar, 250 g of honeysuckle, 250 g of dogwood, 250 g of shizandra berry, 250 g of angelica, 230 g of hawthorn, 230 g of jujube, 230 g of dark plum, 130 g of poria cocos, 130 g of black nightshade and 130 g of dandelion.

Example 5

200 g of rehmannia root, 200 g of red peony root, 200 g of acanthopanax root, 200 g of medlar, 150 g of honeysuckle, 150 g of dogwood, 150 g of shizandra berry, 150 g of angelica, 130 g of hawthorn, 130 g of Chinese date, 130 g of dark plum, 80 g of poria cocos, 80 g of black nightshade and 80 g of dandelion.

The preparation method of the preparation for treating the symptoms caused by kidney yin deficiency comprises the following steps:

Sieving with 5000-8000 mesh sieve after pulverizing.

The solvent is water.

Adding 20-30g of solvent into 100 g of the raw material mixed powder for mixing and pelleting.

The preparation is a pill.

The gram weight of each pill is 0.2-0.3g.

The using method comprises the following steps: each pill weighs 0.2-0.3g, and is taken 2-3 times per day, and 8-10 pills each time.

Taboo: the sour and spicy food is stimulated.

Detection report:

report number: SHA03-22103566-JC-01

Sample name: chinese medicinal pills; sample: the product prepared in example 5 above.

Test items: analysis of traditional Chinese medicine formula

1. The purpose of the experiment is as follows: the chemical composition of the samples was studied using a high resolution liquid chromatograph.

2. Preparation method of test sample

And (3) extracting components: taking 2mg of sample in a 2ml centrifuge tube, adding 1ml of methanol, ultrasonically extracting at 40 ℃ for 20min, centrifuging at 13000rpm for 10min, taking 0.5ml of supernatant, adding 1.5ml of water, uniformly mixing, and waiting for machine inspection. (the preservation time is not more than 24 h).

3. Chromatographic conditions

The chromatographic instrument is as follows: ultiMate 3000 UHPLC, column C18 (1.9 μm,2.1 mm. Times.100 mm).

The flow rate of the inner layer drug analysis was 0.3ml/min, and the sample injection amount was 10. Mu.l. The mobile phase was 0.1% formic acid/acetonitrile (B) -0.1% formic acid/water (a). Gradient elution procedure of the solution is shown in table 1:

Time	a (0.1% FA/water)	B(0.1％FA/ACN)
			0	95	5
15	0	100
			17	0	100
17.1	95	5
			20	95	5

4. Mass spectrometry conditions

The mass spectrometer is a Q-exact (Thermo Fisher Scientific, CA, USA) HESI source, the ion source temperature is 310 ℃, the capillary temperature is 320 ℃, the sheath air flow rate is 30 units, the auxiliary air flow rate is 10 units, the positive ion mode spray voltage is 3kV, and the negative ion mode spray voltage is 2.8kV.

The analysis uses data dependent scanning analysis (DDA), the loop count set point is 10, the HCD energy uses step-wise normalized collision energy, the set points are 10, 28, 35eV. The primary mass spectrum scanning range is 70-1050m/z, the resolution is set to 70000, the AGC target is set to 3E6, and the injection time is set to 200ms. The secondary mass spectrum resolution was set to 17500, agc target was set to 1E5, and injection time was set to 50ms.

5. Experimental results:

FIG. 1 is a base peak chromatogram in a sample positive ion mode.

FIG. 2 is a base peak chromatogram in sample negative ion mode.

Fig. 3 is a sample detection appearance diagram.

6. Analysis of chemical composition of samples:

and (3) automatically searching an mz closed database to analyze and obtain a component list, and manually checking MS2 spectrogram fragments of all results to retain components with higher matching degree and peak area exceeding 5E 7. Through analyzing the sample, the total 154 traditional Chinese medicine components are identified, wherein the traditional Chinese medicine components can be derived from extracts of hawthorn, red paeony root, medlar, dark plum fruit, acanthopanax, honeysuckle, jujube, black nightshade, dandelion, dogwood, shizandra berry, dangshen, angelica, rehmannia root, poria cocos and the like. Wherein the number and the ratio of the identified components of the traditional Chinese medicine are shown in Table 2.

Clinical cases:

case 1: some king, men, 37 years old, henan Zhengzhou Xinmi.

Before taking the medicine, the waist and the knee are usually soreness, weakness, lassitude and hyposexuality.

After the watered pill prepared in the example 5 is taken for 20 days, the symptoms are obviously improved, and the most obvious phenomenon is vigorous sexual desire and obvious morning erection.

Case 2: some of the plums, men, 44 years old, mountain-top county.

Lumbar muscle strain is caused by long-term fatigue before taking medicine, and lumbar pain can occur when long-distance driving is performed each time.

The watered pill prepared in the above example 5 is taken, the symptoms are obviously improved after 10 days, and the phenomenon of lumbago is avoided from flat top mountain to nearly 800 km long sand.

Case 3: in a certain place, men, 63 years old, new people in Zhengzhou in Henan.

The soreness and weakness of waist and knees before taking the medicine is serious, leg pain is serious, and the medicine is not well improved for many years.

The water-paste pill prepared in the above example 5 is taken, and the symptoms are obviously improved after one half month, especially the leg pain is greatly relieved.

Case 4: some women, 36 years old, henan Zhengzhou Xinmi people.

Before taking the medicine, hands and feet are cold and cold feeling is felt.

The water-paste pill prepared in the above example 5 was taken, and the symptoms were significantly improved after one month.

Case 5: liu is somewhere, woman, 43 years old.

The dosage of menstrual flow is very small before taking the medicine, the sleep is difficult, and the sleep is insomnia and dreamful.

The water-paste pill prepared in the above example 5 is taken, and after two months, the menstrual flow is obviously increased, and the phenomenon of insomnia and dreaminess is obviously improved.

Case 6: some women, 56 years old, and the people in the market of the Chao.

Before taking, dizziness, weakness and frequent urination.

The watered pill prepared in the above example 5 was taken, and symptoms recovered after three months.

Case 7: some plum, 70 years old, men.

Before taking, the liver is bad, the eyes have diseases, and the prostatitis.

The water-paste pellets prepared in the above example 5 were taken, and 8 hours of symptoms were relieved.

Case 8: liu is somewhere, female, 52 years old.

Before taking, the patients had soreness and pain of waist and back, cramp of leg, arthralgia and swelling.

The watered pill prepared in the above example 5 was taken, the symptoms were relieved after two months, and the patients were completely recovered after one year.

Finally, it should be noted that: the foregoing description is only of the preferred embodiments of the invention and is not intended to limit the scope of the invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The preparation for treating the symptoms caused by deficiency of kidney yin is characterized by being prepared from the following raw materials in parts by mass:

2. The preparation for treating the kidney yin deficiency induced disorder according to claim 1, wherein the preparation is mainly prepared from the following raw materials in parts by mass:

3. The preparation for treating the kidney yin deficiency induced disorder according to claim 2, wherein the preparation is mainly prepared from the following raw materials in parts by mass:

4. A method of preparing a formulation according to any one of claims 1 to 3 for use in the treatment of a condition caused by deficiency of kidney yin, comprising:

5. The method for preparing a formulation for treating a kidney yin deficiency induced condition according to claim 4, wherein the crushed formulation is sieved through a 5000-8000 mesh sieve.

6. The method of claim 4, wherein the solvent is water.

7. The method for preparing a preparation for treating a kidney-yin deficiency induced condition according to claim 4, wherein 20-30g of solvent is added to 100 g of the raw meal mixture powder for mixing and pelleting.

8. The method of preparing a formulation for treating a kidney yin deficiency induced condition according to claim 4, wherein the formulation is a pill.

9. The method for preparing a formulation for treating a kidney yin deficiency induced disorder according to claim 8, wherein the gram weight per pill is 0.2-0.3g.