CN116327643B - Transdermal penetration-promoting composition, preparation method thereof and application thereof in washing and caring products - Google Patents
Transdermal penetration-promoting composition, preparation method thereof and application thereof in washing and caring products Download PDFInfo
- Publication number
- CN116327643B CN116327643B CN202310297206.4A CN202310297206A CN116327643B CN 116327643 B CN116327643 B CN 116327643B CN 202310297206 A CN202310297206 A CN 202310297206A CN 116327643 B CN116327643 B CN 116327643B
- Authority
- CN
- China
- Prior art keywords
- seed oil
- promoting composition
- transdermal
- noni
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000005406 washing Methods 0.000 title abstract description 11
- 230000001737 promoting effect Effects 0.000 claims abstract description 19
- 238000010521 absorption reaction Methods 0.000 claims abstract description 15
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 77
- 235000019198 oils Nutrition 0.000 claims description 22
- 241000220215 Moringa Species 0.000 claims description 21
- 235000011347 Moringa oleifera Nutrition 0.000 claims description 21
- 235000020238 sunflower seed Nutrition 0.000 claims description 21
- 244000131360 Morinda citrifolia Species 0.000 claims description 20
- 235000017524 noni Nutrition 0.000 claims description 20
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 claims description 17
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 claims description 17
- 235000003901 Crambe Nutrition 0.000 claims description 16
- 241000220246 Crambe <angiosperm> Species 0.000 claims description 16
- 230000035515 penetration Effects 0.000 claims description 16
- 230000002708 enhancing effect Effects 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 6
- 239000001569 carbon dioxide Substances 0.000 claims description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 235000013336 milk Nutrition 0.000 claims description 4
- 239000008267 milk Substances 0.000 claims description 4
- 210000004080 milk Anatomy 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 231100000435 percutaneous penetration Toxicity 0.000 claims description 3
- 239000008269 hand cream Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims 3
- 239000002537 cosmetic Substances 0.000 abstract description 12
- 206010070834 Sensitisation Diseases 0.000 abstract description 2
- 230000008313 sensitization Effects 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 17
- 210000003491 skin Anatomy 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000003961 penetration enhancing agent Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 206010040880 Skin irritation Diseases 0.000 description 5
- 210000002615 epidermis Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000036556 skin irritation Effects 0.000 description 5
- 231100000475 skin irritation Toxicity 0.000 description 5
- 235000016401 Camelina Nutrition 0.000 description 4
- 244000197813 Camelina sativa Species 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 239000003623 enhancer Substances 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 3
- 239000005642 Oleic acid Substances 0.000 description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
- 244000236658 Paeonia lactiflora Species 0.000 description 3
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 231100000344 non-irritating Toxicity 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- 235000020778 linoleic acid Nutrition 0.000 description 2
- 235000021388 linseed oil Nutrition 0.000 description 2
- 239000000944 linseed oil Substances 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 description 1
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- 235000001553 Betula platyphylla Nutrition 0.000 description 1
- 241001313086 Betula platyphylla Species 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 244000061632 Prinsepia uniflora Species 0.000 description 1
- 235000008997 Prinsepia uniflora Nutrition 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000000823 artificial membrane Substances 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- PXGZQGDTEZPERC-UHFFFAOYSA-L cyclohexane-1,4-dicarboxylate Chemical compound [O-]C(=O)C1CCC(C([O-])=O)CC1 PXGZQGDTEZPERC-UHFFFAOYSA-L 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012527 feed solution Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002339 glycosphingolipids Chemical class 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 150000002888 oleic acid derivatives Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000000438 stratum basale Anatomy 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 210000000437 stratum spinosum Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000011003 system suitability test Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a percutaneous permeation promoting composition, a preparation method thereof and application thereof in washing and caring products, and belongs to the technical field of cosmetics. The transdermal penetration-promoting composition has good transdermal absorption promoting effect on the functional components, has good sensitization resistance and improves the safety of washing and protecting products.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a percutaneous penetration-promoting composition, a preparation method thereof and application thereof in washing and caring products.
Background
The skin is the largest organ of the human body, and consists of epidermis, dermis, subcutaneous tissue, hair and sweat glands which are appendages of the skin. The epidermis is the outermost layer of the skin, and can be divided into the stratum corneum, the stratum granulosum, the stratum spinosum, and the stratum basale, which is connected to the dermis by means of the basement membrane. The stratum corneum is the outermost layer of the epidermis and is the primary barrier to the transdermal absorption of foreign substances.
Percutaneous absorption of cosmetics refers to a process in which effective or functional components present in cosmetics act on the surface of the skin or enter different skin layers such as epidermis, dermis, etc. of the skin, accumulate at that site and exert an effective effect. The barrier function of the skin makes many components less permeable to the skin, making it difficult for the functional components of the cosmetic to reach the body transdermally without having an intended effect.
As the demand for functional cosmetics increases, penetration-promoting techniques of cosmetics are becoming more and more important. Chemical permeation enhancers are currently common cosmetic permeation enhancers that use a transdermal absorption enhancer to reversibly alter the barrier function of the stratum corneum of the skin without damaging any active cells, helping to increase the transdermal rate or increase the transdermal amount of the active ingredient. Common penetration enhancers include azone, dimethyl isosorbide, N-N-alkylbenzisothiazolone, cyclohexanethol, tetrahydropiper nigrum, sodium lauryl sulfate, oleic acid and sodium pyrrolidone carboxylate. In recent years, in order to exert efficacy, most of the efficacy cosmetics have been added with a transdermal absorption penetration enhancer, such as CN113855584a, which discloses a transdermal penetration enhancing composition by a variety of oils, which comprises oleic acid or one or more of oleic acid derivatives or oleic acid glycerides; one or more of linoleic acid or a derivative of linoleic acid or a glyceride of linoleic acid; one or more of phospholipids or glycolipids or glycosphingolipids. By combining several permeation promoters, compared with the permeation promoter with single component, the transdermal permeation rate and the accumulated permeation quantity are obviously improved, and the permeation and absorption of the skin to the active ingredients are promoted by multiple actions, so that the water-soluble and oil-soluble active ingredients of the cosmetics are easier to permeate. CN115137667a discloses a cosmetic composition with penetration enhancing effect comprising bis-diethoxydiglycol cyclohexane 1, 4-dicarboxylate, ethoxydiglycol and transdermal oligopeptide TD-1. The invention creatively compounds three components, wherein the bis-diethoxydiglycol cyclohexane 1, 4-dicarboxylic acid ester is a common permeation promoter component, the permeation promoter component is obviously amplified in permeation promoting effect after being combined with the biological permeation promoter transdermal short peptide TD-1, and compared with a single component, the permeation promoting effect is obviously improved, and obvious synergistic effect is obtained; the penetration promoting effect of the further compounded ethoxy diglycol is further improved.
At present, the transdermal absorption penetration enhancer is used for improving the absorption capacity of skin to functional components in cosmetics, but the conventional transdermal absorption penetration enhancer has a general penetration enhancing effect and cannot meet the market demand.
Disclosure of Invention
In order to solve the technical problems, the invention provides a novel transdermal penetration-promoting composition, a preparation method thereof and application thereof in washing and caring products, wherein the transdermal penetration-promoting composition has good penetration-promoting effect, little damage to skin barrier function, good sensitivity, and improves the safety of the washing and caring products while promoting the exertion of functional components.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a percutaneous penetration promoting composition comprises oleum Helianthi, BAIHUA seed oil, moringa seed oil and deep sea herba Angustifoliae seed oil.
The transdermal penetration-promoting composition disclosed by the invention is prepared by combining four vegetable oils of sunflower seed oil, white pool flower seed oil, moringa seed oil and deep sea two-section camelina seed oil, and has a good effect of promoting transdermal absorption on oxidation-resisting functional components.
Preferably, the transdermal penetration-promoting composition comprises the following components in parts by weight: 15-20 parts of sunflower seed oil, 0.1-1 part of white pool flower seed oil, 0.1-1 part of moringa seed oil and 0.1-1 part of crambe seed oil in deep sea.
Further preferably, the mass ratio of the sunflower seed oil to the moringa seed oil to the deep sea two-section camelina seed oil is 16-19:0.1-0.15:0.1-0.15.
Most preferably, the mass ratio of the sunflower seed oil, the moringa seed oil and the deep sea crambe seed oil is 18.06:0.11:0.11.
The transdermal penetration enhancing composition of the present invention further comprises noni seed oil, preferably, the noni seed oil is used in an amount of 0.5 to 1.5 parts by weight, and most preferably, 1 part by weight.
Specifically, the preparation method of the noni seed oil comprises the following steps:
(1) Drying and crushing noni seeds to obtain material powder;
(2) Extracting the obtained material powder by using carbon dioxide to obtain an extract;
(3) And (5) decompressing and separating the extract to obtain noni seed oil.
Preferably, the extraction in step (2) is: the temperature is 60 ℃, the pressure is 25Mpa, and the flow rate of carbon dioxide is 6L/h.
Preferably, the reduced pressure separation in step (3) is a two-stage reduced pressure separation, specifically, the primary separation pressure is 15Mpa and the temperature is 50 ℃; the secondary separation pressure was 5Mpa and the temperature was 30 ℃.
The invention also provides a preparation method of the percutaneous permeation-promoting composition, and the percutaneous permeation-promoting composition is prepared by uniformly mixing sunflower seed oil, white pool flower seed oil, moringa seed oil, deep sea crambe seed oil and noni seed oil according to the formula amount.
The percutaneous permeation promoting composition can penetrate effective components such as antioxidation, anti-inflammatory and the like into the dermis layer, and better plays a role. Based on this, the invention also provides the use of the above transdermal penetration enhancing composition in a washing and caring product.
The washing and caring product comprises facial cleanser, facial mask, scrub, hand cream, essence, body milk, essence water and essence milk.
The invention also provides a washing and caring product containing the percutaneous permeation promoting composition.
Compared with the prior art, the invention has the following beneficial effects:
(1) The transdermal penetration-promoting composition disclosed by the invention is prepared by combining four vegetable oils of sunflower seed oil, white pool flower seed oil, moringa seed oil and deep sea two-section camelina seed oil, and has a good transdermal absorption effect on functional components.
(2) The transdermal penetration-promoting composition has small damage to the skin barrier function and good sensitization, and improves the safety of washing and protecting products while promoting the exertion of the functional components.
Detailed Description
The following examples are presented only to aid in understanding the method of the present invention and its core ideas. It should be noted that it will be apparent to those skilled in the art that various modifications and adaptations of the invention can be made without departing from the principles of the invention and these modifications and adaptations are intended to be within the scope of the invention as defined in the following claims. The following description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The sunflower seed oil, the white pool seed oil, the moringa seed oil, the deep sea crambe seed oil and the linseed oil are purchased from Shanghai Prinsepia xi real company.
Example 1
The percutaneous penetration-promoting composition comprises the following components in parts by weight: 10 parts of sunflower seed oil, 0.1 part of white pool flower seed oil, 1 part of moringa seed oil and 0.1 part of deep sea crambe seed oil.
Example 2
The percutaneous penetration-promoting composition comprises the following components in parts by weight: 20 parts of sunflower seed oil, 1 part of white pool flower seed oil, 0.1 part of moringa seed oil and 1 part of deep sea crambe seed oil.
Example 3
The percutaneous penetration-promoting composition comprises the following components in parts by weight: 16 parts of sunflower seed oil, 0.15 part of white pool flower seed oil, 0.1 part of moringa seed oil and 0.15 part of deep sea crambe seed oil.
Example 4
The percutaneous penetration-promoting composition comprises the following components in parts by weight: 19 parts of sunflower seed oil, 0.1 part of white pool flower seed oil, 0.15 part of moringa seed oil and 0.1 part of deep sea crambe seed oil.
Example 5
The percutaneous penetration-promoting composition comprises the following components in parts by weight: 18.06 parts of sunflower seed oil, 0.11 part of white pool flower seed oil, 0.11 part of moringa seed oil and 0.11 part of deep sea crambe seed oil.
Example 6
This example differs from example 5 in that the transdermal penetration enhancing composition further comprises 0.5 parts noni seed oil;
the preparation method of the noni seed oil comprises the following steps: the method comprises the following steps:
(1) Drying and crushing noni seeds to obtain material powder;
(2) Extracting the obtained material powder by using carbon dioxide at the extraction temperature of 60 ℃ and the pressure of 25Mpa, wherein the flow rate of the carbon dioxide is 6L/h, so as to obtain an extract;
(3) And carrying out secondary decompression separation on the extract, specifically, carrying out primary separation at 15Mpa and 50 ℃ at 5Mpa and 30 ℃ to obtain noni seed oil.
Example 7
This example differs from example 6 in that the amount of noni seed oil in the transdermal penetration enhancing composition is 1.5 parts by weight.
Example 8
This example differs from example 6 in that the amount of noni seed oil used in the transdermal penetration enhancing composition is 1 part by weight.
Comparative example 1
This comparative example differs from example 5 only in that linseed oil is used instead of sunflower seed oil.
Comparative example 2
This comparative example differs from example 5 only in the amounts of sunflower seed oil, moringa seed oil and crambe seed oil in the deep sea;
in particular to a percutaneous permeation promoting composition, which comprises the following components in parts by weight: 8 parts of sunflower seed oil, 5 parts of white pool flower seed oil, 1 part of moringa seed oil and 6 parts of deep sea crambe seed oil.
Comparative example 3
This comparative example differs from example 6 only in that the transdermal penetration enhancing composition is noni seed oil only.
1. Percutaneous absorption of skin (in vitro method)
After the sample is smeared through a diffusion cell, whether paeoniflorin which is an active ingredient of paeonia lactiflora (PAEONIA ALBIFLORA) root extract can be absorbed through skin or not is simulated, so that the optimal selection of skin care is realized. The specific detection method comprises the following steps:
(1) Sample to be measured: weighing 3.0g of the percutaneous permeation promoting composition, adding 5mg of radix paeoniae alba root extract (CAS: 84929-40-8) and 25g of deionized water, placing in a stirrer, stirring for 20min at 50r/min, and adding 0.4% sodium hyaluronate to obtain flowable viscous liquid, namely a feed liquid;
(2) The artificial membrane is placed on the diffusion cell with the light surface facing upwards.
(3) Filling 50% butanediol as receiving liquid in the receiving chamber, placing in a flowing water bath of a percutaneous absorption instrument, performing constant-temperature water bath at 37 ℃ with magnetic stirring speed of 400rpm, balancing for 1h, and discharging bubbles.
(4) 2.0mL of the feed solution was added to the feed chamber, 0.4mL of the receiving solution was aspirated at 5h and 10h, and an equal amount of the blank receiving solution was added.
(5) Measuring paeoniflorin content in the receiving liquid at different time, and calculating the unit area transmission amount at different time points according to the formula (1):
the paeoniflorin content detection method refers to the method under the white peony root content measurement item of the 2020 edition of Chinese pharmacopoeia.
Chromatographic conditions and system suitability test: octadecylsilane chemically bonded silica is used as a filler; acetonitrile-0.1% phosphoric acid solution (14:86) is used as a mobile phase; the detection wavelength was 230nm. The theoretical plate number should be not less than 2000 calculated according to paeoniflorin peak.
Wherein:
q is cumulative transmission per unit area (mg/cm) 2 )；
A is the effective transdermal absorption area (cm) 2 )；
V 0 Is the receiving chamber volume (mL);
v is the sampling volume (mL);
C n the mass concentration (mg/mL) in the receiving liquid measured for the nth sampling point;
C n－ 1 is mass concentration (mg/mL) of paeoniflorin in the receiving solution measured at the n-1 sampling point;
Q n the transmission amount is accumulated for the unit area measured at the nth sampling point.
The cumulative permeation amount per unit area of paeoniflorin the samples to be tested prepared using the transdermal penetration-promoting compositions of examples 1 to 8 and comparative examples 1 to 3 was measured, and the results are shown in Table 1.
TABLE 1 diffusion cell simulation of paeoniflorin permeation for 5h and 10hIs measured in terms of the permeation quantity (mg/cm) 2 )
| Group of | 5h | 10h |
| Example 1 | 0.42 | 0.60 |
| Example 2 | 0.44 | 0.65 |
| Example 3 | 0.59 | 0.74 |
| Example 4 | 0.62 | 0.79 |
| Example 5 | 0.66 | 0.85 |
| Example 6 | 0.72 | 0.90 |
| Example 7 | 0.71 | 0.87 |
| Example 8 | 0.75 | 0.94 |
| Comparative example 1 | 0.30 | 0.35 |
| Comparative example 2 | 0.27 | 0.30 |
| Comparative example 3 | 0.10 | 0.13 |
As is clear from Table 1, the permeation amounts of paeoniflorin in examples 1 to 5 are relatively high, which means that the transdermal permeation promoting compositions of examples 1 to 5 have a good effect on the permeation of paeoniflorin, wherein the transdermal permeation promoting composition of example 5 has a good effect on the permeation of paeoniflorin, and the permeation amounts of paeoniflorin are at most 0.66mg/cm for 5 hours and 10 hours 2 And 0.85mg/cm 2 Examples 4 and 3 follow.
Meanwhile, as is clear from comparative examples 1 and 2, when the composition of the permeation enhancer composition is changed, the permeation amount of paeoniflorin is significantly reduced, indicating that the composition of the transdermal permeation enhancer composition has an important influence on the permeation enhancer effect of paeoniflorin.
In addition, according to examples 6 to 8, the transdermal permeation-promoting composition added with noni seed oil further improves paeoniflorin permeation amount to 0.71-0.75mg/cm after 5 hours 2 The method comprises the steps of carrying out a first treatment on the surface of the The paeoniflorin permeation amount reaches 0.87-0.94mg/cm within 10h 2 . The addition of noni seed oil can further improve the permeation promoting effect of the sun sunflower seed oil, the white pool flower seed oil, the moringa seed oil and the deep sea two-section camelina seed oil on paeoniflorin.
2. Skin irritation test
Reference is made to the "fourth, skin irritation/corrosiveness test", in particular:
(1) Test article: transdermal penetration enhancing compositions provided in examples 1-8;
(2) Test animals: white rabbits;
(3) The test method comprises the following steps:
(1) about 24 hours before the test, the hairs on both sides of the back spine of the experimental animal are cut off, the epidermis can not be damaged, and the hair removing range is about 3cm multiplied by 3cm on the left and right sides.
(2) About 0.5mL (g) of the test object was applied directly to the skin, and then covered with two layers of gauze (2.5 cm. Times.2.5 cm) and one layer of cellophane or the like, and fixed with non-irritating adhesive tape and bandage. The other side skin served as a control. The application time was 4h using the blocking test.
(3) Skin reactions at the smears were observed at 1, 24, 48 and 72 hours after removal of the test subjects, skin reactions were scored according to table 2, the total evaluation was performed on the average of the integral of the test subjects, and skin irritation intensities were determined according to table 2 from the highest integral average at each observation time point of 24, 48 and 72 hours.
Table 2 skin irritation response score
As a result, the transdermal penetration enhancing compositions of examples 1 to 8 were found to have an integral of less than 0.5 and were classified to be non-irritating in terms of skin irritation intensity, indicating that the transdermal penetration enhancing compositions of the present invention were non-irritating to the skin and safe.
Claims (8)
1. The percutaneous penetration promoting composition is characterized by comprising the following components in parts by weight: 10-20 parts of sunflower seed oil, 0.1-1 part of white pool flower seed oil, 0.1-1 part of moringa seed oil and 0.1-1 part of crambe seed oil in deep sea.
2. The transdermal penetration-promoting composition according to claim 1, wherein the mass ratio of sunflower seed oil, moringa seed oil and crambe seed oil is 16-19:0.1-0.15:0.1-0.15.
3. The transdermal penetration-promoting composition according to claim 1, wherein the mass ratio of sunflower seed oil, moringa seed oil and crambe seed oil is 18.06:0.11:0.11.
4. The percutaneous penetration promoting composition is characterized by comprising the following components in parts by weight: 10-20 parts of sunflower seed oil, 0.1-1 part of white pond flower seed oil, 0.1-1 part of moringa seed oil, 0.1-1 part of crambe seed oil in deep sea and 0.5-1.5 parts of noni seed oil.
5. The transdermal penetration enhancing composition according to claim 4, wherein the preparation method of noni seed oil comprises the steps of:
(1) Drying and crushing noni seeds to obtain material powder;
(2) Extracting the obtained material powder by using carbon dioxide to obtain an extract;
(3) And (5) decompressing and separating the extract to obtain noni seed oil.
6. The method for preparing the transdermal penetration-promoting composition according to any one of claims 4 to 5, wherein the method comprises uniformly mixing sunflower seed oil, white pool flower seed oil, moringa seed oil, crambe seed oil and noni seed oil according to the formula amount.
7. Use of a transdermal penetration enhancing composition according to any one of claims 1-5 for promoting transdermal absorption of paeoniflorin in a care product.
8. The use according to claim 7, wherein the cleansing product comprises a facial cleanser, a mask, a scrub, a hand cream, a serum, a body milk, a serum, and a serum milk.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310297206.4A CN116327643B (en) | 2023-03-24 | 2023-03-24 | Transdermal penetration-promoting composition, preparation method thereof and application thereof in washing and caring products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310297206.4A CN116327643B (en) | 2023-03-24 | 2023-03-24 | Transdermal penetration-promoting composition, preparation method thereof and application thereof in washing and caring products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116327643A CN116327643A (en) | 2023-06-27 |
| CN116327643B true CN116327643B (en) | 2023-12-29 |
Family
ID=86894435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310297206.4A Active CN116327643B (en) | 2023-03-24 | 2023-03-24 | Transdermal penetration-promoting composition, preparation method thereof and application thereof in washing and caring products |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116327643B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020217210A1 (en) * | 2019-04-24 | 2020-10-29 | Angela Lagana' Srl | Product, in particular a cosmetic product, for the external or surface treatment of the body |
| CN112089666A (en) * | 2020-10-26 | 2020-12-18 | 广州环亚化妆品科技有限公司 | Antioxidant composition and preparation method and application thereof |
| CN114224787A (en) * | 2021-12-14 | 2022-03-25 | 上海家化联合股份有限公司 | Composition containing vegetable seed oil and fat and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100130462A1 (en) * | 2007-04-20 | 2010-05-27 | Thomas Sherry L | Lanolin compositions and methods for making and using same |
| FR3041249B1 (en) * | 2015-09-18 | 2019-01-25 | Capsum | STABLE EMULSIONS |
-
2023
- 2023-03-24 CN CN202310297206.4A patent/CN116327643B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020217210A1 (en) * | 2019-04-24 | 2020-10-29 | Angela Lagana' Srl | Product, in particular a cosmetic product, for the external or surface treatment of the body |
| CN112089666A (en) * | 2020-10-26 | 2020-12-18 | 广州环亚化妆品科技有限公司 | Antioxidant composition and preparation method and application thereof |
| CN114224787A (en) * | 2021-12-14 | 2022-03-25 | 上海家化联合股份有限公司 | Composition containing vegetable seed oil and fat and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 一种利用核磁共振氢谱表征植物油在头发内渗透性的方法;梁新宇等;《日用化学工业》;第50卷(第4期);第244-248页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116327643A (en) | 2023-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Dreher et al. | Comparison of cutaneous bioavailability of cosmetic preparations containing caffeine or α-tocopherol applied on human skin models or human skin ex vivo at finite doses | |
| KR101746639B1 (en) | Composition with skin lightening and moisturizing effects containing bee venom extracts | |
| KR101134716B1 (en) | Composition of skin external application containing rose extract and epigallocatechin gallate(egcg) | |
| CN106511135A (en) | Whitening compound essential oil and preparation method thereof | |
| CN108014045B (en) | Man skin care composition and application thereof | |
| CN114159347B (en) | Composition with whitening and repairing effects and preparation method and application thereof | |
| KR101352363B1 (en) | Composition of skin external application for moisturizing comprising Scrophularia buergeriana Miq. extract | |
| JP2018162325A (en) | Cosmetic compositions comprising marine plants | |
| CN114224787A (en) | Composition containing vegetable seed oil and fat and application thereof | |
| JP2001288066A (en) | Skin barrier function ameliorator | |
| KR100338327B1 (en) | External application for enhancing the skin permeability of the active components therein | |
| KR20130031988A (en) | Skin external composition containing floral ginsenoside | |
| CN116327643B (en) | Transdermal penetration-promoting composition, preparation method thereof and application thereof in washing and caring products | |
| CN110801412B (en) | Sebum bionic composition, application thereof and cosmetics | |
| CN113425661B (en) | Plant composition with cleaning and repairing effects and application thereof | |
| CN114246816B (en) | Transparent water-oil double-cleansing oil composition and preparation method thereof | |
| KR100306847B1 (en) | Cosmetic composition for whole body | |
| CN112294686B (en) | Cosmetic composition for preventing and/or improving skin aging and application thereof | |
| CN116999346A (en) | Low-irritation high-activity daytime eye cream and preparation method thereof | |
| JP7218166B2 (en) | Skin topical agent | |
| KR102670859B1 (en) | Cosmetic composition for skin moisturizing and soothing and manufacturing method thereof | |
| Hasibuan et al. | Formulation and Evaluation of Body Scrub Cream Containing Ethanol Extract of Black Cumin Seeds (Nigella sativa L.) and Coffee Grounds (Coffea arabica L.) as Anti-aging | |
| CN106727049A (en) | Face cream and preparation method thereof | |
| CN117982375A (en) | Vegetable oil composition for promoting cell proliferation and activity | |
| CN106726741A (en) | A kind of medical cosmetology skin penetration enhancer containing natural plant essence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |