CN1163214C - Agent for skin - Google Patents
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- CN1163214C CN1163214C CNB941135268A CN94113526A CN1163214C CN 1163214 C CN1163214 C CN 1163214C CN B941135268 A CNB941135268 A CN B941135268A CN 94113526 A CN94113526 A CN 94113526A CN 1163214 C CN1163214 C CN 1163214C
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Abstract
The present invention discloses a composition for a skin externally used agent, which does not have conspicuous side effect, but has favorable effects on improving the skin motivation and nursing and nourishing the hair and has the functions of favorable temperature protection and facial beautification.
Description
The present invention relates to a kind of Dermatologic preparation composition, said composition is different from amcinonide, do not have significant side effects for body, it be with strengthen skin function and root of hair cytoactive thereby have good raising skin function and educate send out, hair care effect and to have an extract of defending thatch platymiscium (for example defend thatch, Ilicis Purpureae is defended thatch, Cymbopogon caesius (Nees) Stapf) of good moisture preserving effect and beautification function formulated as neccessary composition.
About the beautification function that prevents skin aging, prevention and treatment freckle and strengthen scalp constantly, root of hair is active and the hair growth promoting, the hair care effect that produce, up to now, people have carried out a large amount of research to amcinonide, blood flow ameliorant and various cell activation composition, various active ingredient are tested, cooperated, but, effect good and safe especially and few, and, these it is said medicative composition, if estimate its effectiveness objectively, major part also just rests on the level that preventive effect is only arranged.
The objective of the invention is to develop a kind of skin preparations for extenal use, it has good safety, stability, can promote the skin function and produce beautification function, have educate send out, hair care effect thereby can treat baldness, have good preventing alopecia effect for the people that baldness does not take place, also have facilitation in addition and prevent the skin aging effect.
The feature of skin preparations for extenal use of the present invention is, mixes Wei Mao in this skin preparations for extenal use substrate, Ilicis Purpureae is defended thatch, Cymbopogon caesius (Nees) Stapf etc. and defends the extract of thatch platymiscium as neccessary composition.
In addition, the feature of second skin preparations for extenal use of the present invention is, to extract thing and known other the external agent composition that makes up a prescription compound and constitute with defending the thatch platymiscium.
Skin preparations for extenal use of the present invention, have educate send out, the hair care effect, be used as hair care and cosmetics for skin especially.
Wei Mao (Euonymus) platymiscium is that Sapindales is defended the Mao Ke plant, is distributed in Japan and ground such as China widely, wherein have severally to be cultivated as garden trees or hedge by people, and be the xylophyta that mainly is distributed in the subtropical zone.
That uses among the present invention defends the thatch platymiscium, wherein representational can enumerating: Wei Mao (Euonymus alata Sieb.), Cymbopogon caesius (Nees) Stapf (Euonymus japonica Thunb.), Cymbopogon caesius (Nees) Stapf (Euonymus radicons Sieb.) and variation kind-non-beautiful Mao Zhongyemao, Da Ye thatch Ju Mao, river thousand thatches, コ バ ス サ キ, オ オ Star Le マ サ キ etc.
The thatch genus plants extract of defending of the present invention, when extracting, can use in leaf, stem and the root of defending the thatch platymiscium any, can be singly with a kind of also can be several and be used as the raw material that extracts usefulness, in addition, can also be as required merging use by the composition of extractions such as root, stem respectively.Similarly, the extraction plant of using as raw material not necessarily must be single plant, also can be more than two kinds (for example defend thatch and Ilicis Purpureae is defended thatch) and use.
The method of extracting, for example can adopt will be based on the integral body chopping of the stem that defends thatch, the reuse homogenizer is made semimobile liquid, gained is squeezed the juice and can directly be used, and perhaps also can concentrate the back and use, but, preferably at the mince of plant or utilize and add appropriate solvent in the half mobile liquid of homogenizer preparation and extract, evaporate formed supernatant with freeze dryer, the gained components in certain proportion is admixed in the substrate of skin preparations for extenal use, be mixed with cosmetics for skin.
Extracting the solvent of usefulness for example can enumerate: water, ethanol, normal propyl alcohol, the tert-butyl alcohol, propylene glycol, 1, hydrophobic solvents such as hydrophilic solvent such as 3-butanediol or chloroform, ether, use therefrom select a kind of separately or select to form mixed solvent more than two kinds.Extraction can at room temperature be carried out, also can heat or heating condition under carry out.When adopting solvent extraction method, plant not only can be undressed fresh plant body, also can be dry body, partial desiccation body.
For follow-up processing ease is carried out, can as required solvent extractable matter be concentrated or concentrate and do admittedly, and then use, can adopt conventional method precipitation to remove the composition that starch isoreactivity contained in the solvent extractable matter is not had influence in case of necessity.
The extract of allocating in the skin preparations for extenal use of the present invention of defending the thatch platymiscium, calculating according to the weight that is converted into dry substance is 0.001-10% (w/w), preferably 0.01-5% (w/w).
The details of defending the contained effective ingredient of thatch platymiscium extraction thing that works as neccessary composition in the skin preparations for extenal use of the present invention is at present also fuzzy, by inference, be to contain organic compound such as sterols, flavone compound class, alkaloids, Saponin class, organic acid, coumarin series compounds class in this plant extract to have brought into play good cell function facilitation and moisture-keeping function.
The inventor has carried out long term studies at defending the thatch genus plants extract to the effect of Rhizoma Imperatae cell and Skin Cell, thereby has finished the present invention.
Use cultured cell and laboratory animal to carry out experimental study with regard to skin preparations for extenal use of the present invention for the effect of Skin Cell and hair follicle, one of them experimental example is described below.
Experimental example
Laboratory animal-C3H Mus that use is generally adopted when the effectiveness of assessing hair growth effect (6 age in week), (Hand Plucking) pulls out totally (the about 4cm of area with the chaeta at its back with the pulled wool method
2), amount to 10 (5 every group) above-mentioned laboratory animals to two groups, apply experimental liquid (in 60% ethanol water the Ilicis Purpureae of dissolving 1% amount defend the extract of Mao Ye and stem and 1% Ilicis Purpureae that obtains is defended the thatch extracting solution) and tester solution (60% ethanol water) respectively in its part of removing chaeta, 200 μ l once a day, carried out continuously 25 days, and finished until hair regeneration.
Count when beginning to apply experimental liquid, at the 13rd day, the 15th day and the 19th day, win 20 hairs on one's body from every animal, measure its length with the amplification measurement method, the reuse computer carries out statistical analysis.Analyze its effectiveness.
The gained result is as follows.
| Group (number of elements) | 1 group (5) | 2 groups (5) |
| Experimental liquid (test portion) | 1% Ilicis Purpureae is defended the thatch extracting solution | 60% ethanol contrast liquid |
| Average (mm) the 13rd day ± S.D value of staple length the 19th day on the 15th | * 2.61±0.13 * 4.83±0.23 * 6.08±0.15 | * 2.36±0.12 * 4.24±0.17 * 5.44±0.14 |
| The thickness (μ m) of hair the 19th day on the 15th on the 13rd | * 67.7±0.01 * 68.2±0.0093 * 81.5±0.0106 | * 56.7±0.0138 * 62.0±0.0064 * 62.0±0.0107 |
* 1% appreciable error in relatively the risk between represent to obtain two groups by statistical analysis (T check).
By the result of present embodiment as can be seen, effective ingredient of the present invention can promote the growth of the skin and the hair of body, promotes the skin function, has good setation, educates the capillary effect fruit.
The detailed mechanism that produces this effect is not clear at present, it is believed that, be because the effective ingredient in the extract of the present invention infiltrates in the skin, make skin and Rhizoma Imperatae cell activation, and the prosperity of promotion and the closely-related blood capillary of hair growth, directly strengthen the function of Skin Cell, the state that scalp and hair are kept fit.
In order further to improve the hair growth promoting of defending the thatch platymiscium of the present invention, the hair care facilitation effect, the inventor is also to known material (3-carboxyl propyl group)-trimethylammonium chloromethyl ester with hair care effect, 6-amino-1,2-dihydro-hydroxyl-imino group-4-piperidinyl pyrimidine, 7-chloro-3-methyl-2H-phendioxin, 2,4-thiadiazine-1, the 1-dioxide, polyoxyethylene sorbitan monostearate (20E.O.), work as medicament extracting solution, the acetylene estradiol, prolonging careless extracting solution of life and Radix Sophorae Flavescentis extractive liquid etc. studies with the compound action of defending the thatch genus plants extract, found that, with known hair growth promoting, the hair care composition with defend the compound use of thatch genus plants extract, owing to good enhancement skin function effect demonstrates the promotion hair growth promoting, the synergy of hair care, thus second invention finished.
20 molecules of 20E.O. representative ring oxidative ethane hereinbefore.
Except above-mentioned hair growth promoting, hair care composition, the inventor also known skin irritation mechanism composition, cholinergic mechanism of action composition, epinephrine inhibited mechanism of action composition and the vascular smooth muscle relaxation mechanism of action with the effect of promotion cutaneous circulation is become to grade and the external agent effects such as promotion hair care of defending the compound use of thatch platymiscium and producing of the present invention are studied, and the result has confirmed the effectiveness of these compositions is further enhanced.
In addition, in order to improve the percutaneous absorbance of defending the thatch genus plants extract, compound wetting agent, cutin softening agent, the surfactant used always in the cosmetics of having added found that the absorbance in skin has increased in external agent of the present invention.
The concentration of allocating into of defending the thatch genus plants extract that is used as skin preparations for extenal use in the present invention is advisable with 0.01-5.0%; The concentration of (3-carboxyl propyl group)-trimethyl ammonium chloromethyl ester of allocating in containing hair growth promoting that 0.01-5.0% defends the thatch genus plants extract, hair care promoter is advisable with 0.01-5.0%; Similarly, 6-amino-1, the concentration of allocating into of 2-dihydro-hydroxyl-imino group-4-piperidinyl pyrimidine is advisable with 0.01-5.0%; 7-chloro-3-methyl-2H-phendioxin, 2,4-thiadiazine-1, the concentration of allocating into of 1-dioxide also is to be advisable with 0.01-5.0%; The concentration of allocating into of polyoxyethylene sorbitan monostearate (20E.O.) is advisable with 1.0-60%; When the concentration of allocating into of medicament extracting solution (dry weight 1g is equivalent to extracting solution 1g) is advisable with 0.01-5%; The concentration of allocating into of acetylene estradiol is advisable with 0.001-0.1%; Prolonging the concentration of allocating into of the careless extracting solution of life (dry weight 1g is equivalent to extracting solution 1g) is advisable with 0.01-10.0%; The concentration of allocating into of Radix Sophorae Flavescentis extractive liquid (dry weight 1g is equivalent to extracting solution 1g) is advisable with 0.01-10.0%.
Thereby known can suppress lipid peroxide have the skin aging of preventing composition allocate concentration into, for example Radix Scutellariae extract 0.01-10.0%, vitamin E 0.1-5%, Aloe extract 0.01-10.0% are comparatively suitable.
Skin moisturizer can use wetting agent commonly used, as glycerol, propylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, PEG (Polyethylene Glycol) class, ethohexadiol, sugar alcohols (for example Sorbitol etc.), mucopolysaccharide (for example hyaluronate, chondroitin sulfate, PCA salt) etc., it allocates concentration into can be by scope commonly used, and preferred range is 0.1-10%.
Keratolytic adopts salicylic acid, carbamide etc., and allocating concentration into is 0.1-10%.
Anion surfactant N-lauroyl glutamine hydrochlorate etc., non-ionic surface active agent is allocated concentration into and is advisable with 0.1-5.0% with ten glyceryl monolaurates, polyoxyethylene sorbitol acid anhydride class, polyoxyethylene hardened castor oil etc.
The substrate of using in hair growth promoting of the present invention, the hair care promoter, general substrate-Water-borne modification agent of using in the external agent, alcohol solvent and common substrate-vanishing cream, colloid, the ointment etc., can also use bases such as detergents such as cosmetic materials such as foundation cream, lip pomade, shampoo, surfactant, soap and baths, now confirm, adopt these substrate can bring into play excellent effect of the present invention fully.
Production Example
Below, as Production Example, the object lesson of the extracting method of thatch genus plants extract is defended in narration, but extracting method is not limited to these Production Examples.
Production Example 1
Ilicis Purpureae is defended the leaf of thatch and stem is cataclasm with grinder-mixer, it is squeezed the juice through after filtering, and removes chlorophyll with centrifugal separator, and the part that boils off behind the moisture is used for the present invention as extract.
Production Example 2
The thing that fritters of defending the leaf of thatch and stem is put into the ethanol of equivalent and flooded, move into subsequently in the soxhlet's apparatus, heat with ethanol and extracted 8 hours, cool off extracting solution then, filter, be used for the present invention as extract with the product behind the evaporating solvent.
Production Example 3
Ilicis Purpureae is defended the propylene glycol that thing is put into equivalent that fritters of the stem of thatch and root: the solvent of distilled water=1: 1 floods, adopting batch process to add the relaxing the bowels with purgatives of warm nature dipping at 50 ℃ extracted 24 hours, cool off then, filter, boil off solvent, gains use for the present invention as extract.
Part embodiment of the present invention below is described, but the present invention is not limited by these embodiment.
External agent of the present invention, the composition of in the following examples, enumerating, can also be further with addition of other composition of now having known for skin, hair benefit.
Embodiment 1
Adopt conventional method, the gluey hair care cosmetics that have good hair care effect by following formulated.
Unit: g
Defend thatch plant extract 1.0
7-chloro-3-methyl-2H-1,2, the 4-benzo
Thiadiazine-1,1-dioxide 1.0
Concentrated glycerin 2.0
Ethohexadiol 2.0
Hinokitiol 0.01
Ten glyceryl monolaurates 0.5
CVP Carbopol ETD2050 0.5
Triethanolamine is an amount of
Spice is an amount of
Ethanol 30.0
Water ※ full dose 100.0
(※ add total amount is 100.0g behind the water)
Embodiment 2
The shampoo hair care cosmetics that have good hair care effect with conventional method by following formulated.
Unit: g
Ilicis Purpureae is defended thatch plant extract 1.5
Concentrated glycerin 5.0
Salicylic acid 0.1
POE hardened castor oil (50E.O.) 0.5
Ethanol 30.0
The spice trace
Buffer is an amount of
Water ※ total amount 100.0
(※ add total amount is 100.0g behind the water)
Above, PEO is the expression polyoxyethylene, E.O. representative ring oxidative ethane.
Embodiment 3
Shampoo (lo-tion) the hair care cosmetics that have good hair care effect with conventional method by following formulated.
Unit: g
Defend thatch plant 1,3 butylene glycol extract 2.0
Radix Sophorae Flavescentis extractive liquid 5.0
Carbamide 1.0
β-glycyrrhizic acid 0.1
N-sodium lauroyl glutamate 0.5
The spice trace
Buffer is an amount of
Ethanol 50.0
Phenyl phenol 1.0
Water ※ total amount 100.0
(※ add total amount is 100.0g behind the water)
Embodiment 4
Unit: g
Cymbopogon caesius (Nees) Stapf plant extract 0.5
(3-carboxyl propyl group)-trimethyl ammonium
Chloromethyl ester 1.0
Concentrated glycerin 3.0
Isopropyl methyl phenol 0.3
Ten glyceryl monolaurates 0.5
Salicylic acid 0.5
The spice trace
Buffer is an amount of
Ethanol 40.0
Water ※ total amount 100.0
(※ add total amount is 100.0g behind the water)
Embodiment 5
Unit: g
Ilicis Purpureae is defended thatch plant extract 1.0
6-aminoacid-1,2-dihydro oxyimino
-4-piperidinopy rimidine 1.0
Concentrated glycerin 25.0
Salicylic acid 0.5
Polyoxyethylene hardened castor oil (50E.O.) 0.5
Isopropyl methyl phenol 0.3
The spice trace
Buffer is an amount of
Ethanol 60.0
Water ※ total amount 100.0
(※ add total amount is 100.0g behind the water)
Embodiment 6
The shampoo hair care cosmetics that have good hair care effect with conventional method by following formulated.
Unit: g
Defend thatch plant extract 5.0
Lauryl POE (3) sulfuric ester sodium salt 30.0
Sodium lauryl sulfate salt 15.0
Ethylene glycol monostearate 3.0
N-lauroyl diethanolamine 2.0
Lanolin derivative 1.0
Hydrolysis of keratin 3.0
The spice trace
The pigment trace
Water ※ total amount 100.0
(※ add total amount is 100.0g behind the water)
Above, POE represents polyoxyethylene.
Embodiment 7
Prepare hair care surfactant cosmetics by following prescription with conventional method with good hair care effect.
Unit: g
Ilicis Purpureae is defended thatch plant extract 3.0
Stearoyl trimethyl ammonium chloride 2.0
Hexadecanol 2.0
Silicone oil 3.0
Oil base POE (10) alcohol ether 1.0
Glycerol 5.0
Hydrolysis of keratin 2.0
The spice trace
The pigment trace
Water ※ total amount 100.0
(※ add total amount is 100.0g behind the water)
Above, POE represents polyoxyethylene.
Embodiment 8
Has the good cosmetic vanishing cream that prevents skin aging and brighten cosmetic result by following formulated.
Unit: g
Cera Flava 6.0
Hexadecanol 5.0
Reduction lanoline 8.0
Three decanes 37.5
Fatty acid glycerine 4.0
Glyceryl monostearate 2.0
The polyoxyethylene sorbitol acid anhydride
Monolaurate (20E.O.) 2.0
Ilicis Purpureae is defended thatch plant extract 2.0
Spice is an amount of
Antiseptic, antioxidant are an amount of
Propylene glycol 5.0
Distilled water total amount 100.0
Embodiment 9
Has the good cosmetic vanishing cream that prevents skin aging and brighten cosmetic result by following formulated.
(preventing the compound example of skin aging composition) with other
Unit: g
Cera Flava 6.0
Hexadecanol 5.0
Reduction lanoline 8.0
Three decanes 37.5
Fatty acid glycerine 4.0
Glyceryl monostearate 2.0
The polyoxyethylene sorbitol acid anhydride
Monolaurate (20E.O.) 2.0
Defend thatch plant extract 1.0
Tocopheryl acetate (preventing the composition of skin aging) 0.5
Spice is an amount of
Antiseptic, antioxidant are an amount of
Propylene glycol 5.0
Distilled water total amount 100.0
Embodiment 10
Has the good lotion that prevents skin aging and brighten cosmetic result by following formulated.
Unit: g
Glycerol 5.0
Propylene glycol 4.0
Oleyl alcohol 0.1
The polyoxyethylene sorbitol acid anhydride
Monolaurate (20E.O.) 1.5
Polyoxyethylene lauryl ether 0.5
Cymbopogon caesius (Nees) Stapf plant extract 0.5
Ethanol 10.0
Spice is an amount of
Antiseptic, antioxidant are an amount of
Distilled water total amount 100.0
Embodiment 11
The lipstick that has good heat insulation effect and the effect of activation lip cell by following formulated.
Unit: g
Oleum Ricini 48.8
Hexadecanol 27.0
Lanoline 4.0
Cera Flava (yellow) 5.0
Ceresine 4.0
Candelilla wax 7.0
Brazil wax 2.0
Ilicis Purpureae is defended thatch plant extract 1.0
Antiseptic, antioxidant are an amount of
Titanium oxide 2.0
Yellow No. 202 0.5
Orange No. 211 0.2
Spice is an amount of
Experimental example
The healthy male that respectively presents 35-51 year of middle age property alopecia symptom with 4-7 is one group, and every day 1-2 time, about at every turn 3ml continues coating experimental liquid 3 months, and the result has obtained hair growth promoting described below, hair care effect.
Evaluation criteria
After 3 months, the gross density algoscopy of the bristle hair shaft number of employing mensuration per unit area and scoring (SCORE) method of evaluating by photograph are evaluated the situation of the generation new hair of coating part, and the standard of scoring is as follows:
Almost do not have hair in 1 minute, can only see a spot of
Fur.
Can see at the alopecia position in 2 minutes many furs and
A small amount of bristle
At the alopecia position dense fur was arranged in 3 minutes, and energy
See the bristle about half
All covered in 4 minutes, but can also see by bristle
Scalp.
The state of 5 fens alopecia spots, sparse hair is complete
Can't see.
According to above-mentioned point system, it is effective improving the above person of one-level.
Result of the test is as follows:
1) containing the 1.0% promotion hair growth promoting, the effective percentage of hair care of skin preparations for extenal use of the present invention of defending the ethanol extraction of thatch plant in substrate 1 is 74.5%.
2) in substrate 1, contain 1.0% (3-carboxyl propyl group)-trimethyl ammonium chloromethyl ester and 0.5% Ilicis Purpureae and defend the hair growth promoting of thatch plant extract, the effective percentage of hair care promoter, promote that than the hair growth promoting that only contains 1.0% (3-carboxyl propyl group)-trimethyl ammonium chloromethyl ester in the substrate 1, hair care effective percentage is high by 6.2%, thereby confirmed that Ilicis Purpureae defends the synergy of thatch plant alcohol extracts.
3) in substrate 2, contain 1.0% 6-amino-1,2-dihydro oxyimino-4-piperidinopy rimidine and 0.5% Ilicis Purpureae are defended the hair growth promoting of thatch plant extract, the effective percentage of hair care promoter, than the 6-amino-1 that only contains 1.0% in the substrate 2, the hair growth promoting of 2-dihydro oxyimino-4-piperidinopy rimidine, the effective percentage of hair care promoter exceed 9.8%, thereby have confirmed that Ilicis Purpureae defends the synergy that the thatch plant alcohol extracts produces.
4) in substrate 3, contain 7-chloro-3-methyl-2H-[phendioxin of 1.0%, 2, the 4-thiadiazine]-1,1-dioxide and 1.0% Ilicis Purpureae are defended the hair growth promoting of thatch plant extract, the effective percentage of hair care promoter, than the 7-chloro-3-methyl-2H-[phendioxin that only contains 1.0% in the substrate 3,2,4-thiadiazine]-1, the effectiveness of the hair growth promoting of 1-dioxide, hair care promoter exceeds 12.1%, thereby has confirmed that Ilicis Purpureae defends the synergy of thatch plant alcohol extracts.
5) in substrate 1, contain 50% polyoxyethylene sorbitan monostearate (20E.O.) and 0.5% Ilicis Purpureae and defend the hair growth promoting of thatch plant extract, the effective percentage of hair care promoter, effective percentage than the Hair grower that only contains 50% polyoxyethylene sorbitan monostearate (20E.O.) in the substrate is high by 8.5%, thereby has confirmed that Ilicis Purpureae defends the synergy of thatch plant alcohol extracts.In addition, have only the use level of polyoxyethylene sorbitan monostearate (20E.O.) will deduct the water yield of substrate.
6) in substrate 1, contain 1.0% and defend the hair growth promoting of thatch plant alcohol extracts, the effective percentage of hair care promoter when medicament extracting solution (being equivalent to dry weight 1g) and 0.5% Ilicis Purpureae, higher by 7.4% than the effective percentage that only contains 1.0% hair growth promoting, hair care promoter in the substrate 1 when medicament extracting solution (being equivalent to dry weight 1g), thus the confirmation Ilicis Purpureae is defended the synergy of the ethanol extract of thatch plant.
7) in substrate 1, contain 0.1% ethinyl estradiol and 0.5% Ilicis Purpureae and defend the hair growth promoting of thatch plant alcohol extracts, the effective percentage of hair care promoter, effective percentage than the hair growth promoting that only contains 0.1% ethinyl estradiol in the substrate 1, hair care promoter is high by 6.9%, thereby confirms the synergy of Ilicis Purpureae health thatch plant and ethanol extraction.
8) in base 1, contain the hair growth promoting that 2.0% (being equivalent to dry weight 2g) prolonged life careless extracting solution and 2.0% (being equivalent to dry weight 2g) Radix Sophorae Flavescentis extractive liquid, the effective percentage of hair care promoter, to prolong the situation of the careless extracting solution of life high by 6.9% than only containing for 2.0% (being equivalent to dry weight 2%) in the substrate, thereby confirm that Ilicis Purpureae defends the synergy of thatch plant alcohol extracts.
Be used to prepare various substrate composed as follows of the hair growth promoting that is for experiment, hair care promoter:
Substrate 1
Unit: g
Concentrated glycerin 3.0
Isopropyl methyl phenol 0.3
Ten glyceryl monolaurates 0.5
Salicylic acid 0.5
The spice trace
Ethanol 40.0
Water inventory 100.0
Substrate 2
Unit: g
Concentrated glycerin 25.0
Isopropyl methyl phenol 0.3
Polyoxyethylene hardened castor oil (50E.O.) 0.5
Salicylic acid 0.5
The spice trace
Ethanol 60.0
Water inventory 100.0
Substrate 3
Unit: g
Concentrated glycerin 2.0
Isopropyl methyl phenol 0.3
Ten glyceryl monolaurates 0.5
Carbamide 1.0
CVP Carbopol ETD2050 0.5
The triethanolamine trace
Ethyl hexane glycol 2.0
The spice trace
Ethanol 30.0
Water inventory 100.0
Claims (7)
1. defend the application of thatch genus plants extract in the preparation hair tonic preparation.
2. the described application of claim 1 is characterized in that, described hair tonic preparation is that compound allocating into defended thatch genus plants extract and known other composition that is used and constituted in the external agent in hair tonic preparation substrate.
3. claim 1 or 2 described application is characterized in that, the described thatch platymiscium of defending is that Wei Mao, Ilicis Purpureae are defended thatch or Cymbopogon caesius (Nees) Stapf.
4. each described application among the claim 1-3 is characterized in that, calculates according to the weight that is converted into dry substance (w), and the content of extract in hair tonic preparation of defending the thatch platymiscium is 0.001-10% (w/w).
5. the application described in the claim 4, wherein the extractive content of burning buss is 0.01-5% (w/w).
6. the described application of claim 2, it is characterized in that, the known composition that is used in the external agent is to be selected from one or two or more kinds following material: (3-carboxyl propyl group)-trimethyl ammonium chloromethyl ester, 6-amino-1,2-dihydro-hydroxyl-imino group-4-piperidinopy rimidine, 7-chloro-3-methyl-2H-phendioxin, 2,4-thiadiazine-1,1-dioxide, polyoxyethylene sorbitan monostearate, when medicament extracting solution, ethinyl estradiol, prolong careless extracting solution of life and Radix Sophorae Flavescentis extractive liquid.
7. each described application among the claim 1-6 is characterized in that, the external agent of hair tonic preparation is liquor, cold cream agent, colloid cold cream agent, ointment or solid agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB941135268A CN1163214C (en) | 1994-12-26 | 1994-12-26 | Agent for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB941135268A CN1163214C (en) | 1994-12-26 | 1994-12-26 | Agent for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1125569A CN1125569A (en) | 1996-07-03 |
| CN1163214C true CN1163214C (en) | 2004-08-25 |
Family
ID=5036745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB941135268A Expired - Lifetime CN1163214C (en) | 1994-12-26 | 1994-12-26 | Agent for skin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1163214C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2871060B1 (en) * | 2004-06-08 | 2008-07-11 | Ajinomoto Kk | SUPPRESSOR AGENT FOR INFLAMMATION AND METHOD USING THE SAME |
| CN105112158B (en) * | 2015-07-27 | 2018-04-06 | 河南红枫种苗股份有限公司 | White Galaxy extract and preparation method and application |
| CN105001989B (en) * | 2015-07-27 | 2018-04-06 | 河南红枫种苗股份有限公司 | White Galaxy essential oil and preparation method and application |
| CN104974848B (en) * | 2015-07-27 | 2018-05-08 | 河南红枫种苗股份有限公司 | White Galaxy extract and its extracting process and application |
| CN106265118A (en) * | 2016-08-24 | 2017-01-04 | 登封市科创商务咨询有限公司 | Plectranthin shines skin facial cream |
| CN107693457A (en) * | 2017-11-16 | 2018-02-16 | 东兴市良佳优农林科技有限公司 | Itch-stopping shampoo |
-
1994
- 1994-12-26 CN CNB941135268A patent/CN1163214C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1125569A (en) | 1996-07-03 |
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