CN116270878A - 一种防治奶牛乳房炎的中药口服液及其制备方法 - Google Patents
一种防治奶牛乳房炎的中药口服液及其制备方法 Download PDFInfo
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Abstract
本发明属于中兽药制剂技术领域,公开了一种防治奶牛乳房炎的中药口服液,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英8‑15份、王不留行8‑15份、瓜蒌6‑9份、漏芦6‑9份,连翘4‑8份、夏枯草4‑8份、天花粉4‑8份、紫花地丁4‑8份、玄参3‑5份、知母3‑5份,青皮3‑5份、香附3‑5份,黄芪4‑8份、当归4‑8份,甘草2‑4份。本发明中药组方采用纯天然中草药,配方合理,制备方法简单,制成口服液,使用更加方便,吸收利用迅速,不易产生耐药性的特点,无任何毒副作用,缩短恢复期,保证奶牛的健康及产奶量。
Description
技术领域
本发明属于中兽药制剂技术领域,涉及一种防治奶牛乳房炎的中药口服液及其制备方法。
背景技术
乳房炎,又称乳痈、奶黄、奶肿,是由于瘀血毒气凝结于乳房而成为痈肿,乳房出现硬、肿、热、痛,病牛拒绝幼畜吃奶或人工挤奶的一种疾病,多见于产后哺乳期的母牛,特别是泌乳期的奶牛更为多见。据统计,乳房炎占奶牛总发病的21%~23%。因其造成奶量下降,病乳废弃,甚至由于乳区化脓、坏疽、萎缩以至永久失去泌乳能力,导致奶牛淘汰,给奶牛业带来了很大损失。每年因乳房炎而被淘汰的奶牛占总淘汰率的9%~10%。本病多发于泌乳奶牛的初期和高产奶牛的泌乳高峰期,严重影响奶牛的产奶量、乳品质、生殖机能和利用年限,影响人体健康。
长期以来,世界各地均把抗生素列入治疗乳房炎的首选药物,但由于长期反复使用,导致病原菌产生耐药性,使用药量越来越大,加重治疗费用,导致抗生素治疗失败和抗生素滥用。乳汁中抗生素残留,已引发了食品公共卫生问题,危害人体健康。因此,当前奶牛业迫切需要研制开发安全高效、无残留、无抗药性的防治奶牛乳房炎的药物,从而提高牛奶品质。
中医“治未病”理论分为“未病先防、既病防变、愈后防复”等三个方面。中医药纯天然、资源丰富、毒副作用小、无药物残留、无耐药性、无环境污染,可克服使用抗生素的不足,并兼有药物与营养剂的双重功能。因此,推广应用中草药预防和治疗奶牛乳房炎不仅是畜牧业可持续发展的要求,也是发展绿色食品和提高生活质量的需要。
授权公告号为CN 101780199B的发明专利公开了用于治疗奶牛乳房炎的中药乳房灌注液及制备方法,所述中药乳房灌注液包括以下组分:瓜子金10-40重量份,鸡血藤10-30重量份,元宝草10-25重量份,半枝莲10-25重量份,青皮10-20重量份,甜地丁10-40重量份,毛诃子10-20重量份,紫花地丁10-40重量份,香附10-20重量份,黄芪10-30重量份,泽兰10-30重量份。该乳房灌注液是由中药提取物制成的纯中药制剂,有效成分含量高,对引起奶牛乳房炎的常见病原菌如金黄色葡萄球菌、大肠杆菌等均有较强的抑制作用。但是,治疗时需无菌灌注乳房灌注液30-50mL,每天两次,连续一周,乳室注射操作不方便,并对乳头、乳管也有刺激。
授权公告号为CN 1199676C的发明专利公开了一种痢热清(清热消炎)注射液,由千里光、野菊花、柴胡、金银藤、板蓝根经蒸馏法、水醇浸提法提取有效成分后多步混合配伍精制而成,具有清热解毒消肿、抗菌抗病毒消炎功效,用于治疗各种家畜流行感冒、上呼吸道感染、肺炎、猪肺疫、消化道感染、传染性胃肠炎、腹泻痢疾、仔猪白痢黄痢、乳腺炎、疮黄肿毒、皮肤感染、高热性疾病、病毒感染等。但是,静脉注射对药物的剂型、操作要求较高;肌肉注射会产生强烈的应激反应。
授权公告号为CN102579597B的发明专利公开了一种防治哺乳类家畜乳房炎的中药复方,治疗奶牛隐性乳房炎可降低牛乳中的体细胞数,提高产奶量,而不影响乳的质量。但是,该中药制剂第一种方法未进行中草药有效成分分离提取,造成使用量大,吸收不好。第二种方法加水浸泡,煎煮2次合并滤液,使用不便。
综上,加强中草药研究防治奶牛乳房炎,取代抗生素和化学药物,实现绿色养殖,生产无抗牛奶,在奶牛生产实践中具有重要意义。
发明内容
本发明针对现有技术中中药注射制剂使用不便、产生刺激反应等缺点,提供一种防治奶牛乳房炎的中药口服液及其制备方法,采用纯天然中草药,配方合理,制备方法简单,制成口服液,使用更加方便,吸收利用迅速,不易产生耐药性的特点,无任何毒副作用,缩短恢复期,保证奶牛的健康及产奶量。
为实现上述目的,本发明采用以下技术方案:
本发明提供一种防治奶牛乳房炎的中药口服液,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英8-15份、王不留行8-15份、瓜蒌6-9份、漏芦6-9份,连翘4-8份、夏枯草4-8份、天花粉4-8份、紫花地丁4-8份、玄参3-5份、知母3-5份,青皮3-5份、香附3-5份,黄芪4-8份、当归4-8份,甘草2-4份。
在一个技术方案中,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英8份、王不留行15份、瓜蒌9份、漏芦9份,连翘5份、夏枯草4份、天花粉6份、紫花地丁8份、玄参5份、知母4份、青皮4份、香附5份、黄芪7份、当归7份、甘草4份。
本发明还提供一种防治奶牛乳房炎的中药口服液的制备方法,包括以下步骤:
称取上述中药组分,加入5-10倍纯化水,冷水浸20-60min,煎煮三次,每次均加热煎煮20-60min,将三次煎煮液合并并用80-120目滤网过滤,然后在70-90℃条件下减压浓缩至相对密度1.05-1.10,向浓缩液内添加95%乙醇,边加乙醇边搅拌,至乙醇含量达到40%-60%,静置12-24h后,取上清液用80-120目滤网过滤,得水提醇沉液,最后在70-90℃条件下减压浓缩至相对密度1.05-1.10,得浓缩药液;
向浓缩药液加入0.2-0.5g甜菊素、0.05-0.1g尼泊金乙酯,搅拌均匀后,离心取上清液,加纯化水至100mL,搅拌均匀,分装,105℃流通蒸汽灭菌30-60min,即得治疗奶牛乳房炎的中药口服液。
本品用法用量:
治疗量:150mL/日,连用5-10天。
预防量:①泌乳期:50mL/日,连用3-5天,每月使用2次。②围产期:产前一周和产后一周,50mL/日,连用3-5天。
各组分药物的特性如下:
(1)蒲公英:
功能:清热解毒,消肿散结,利尿通淋。
主治:1、痈肿疔毒,乳痈内痈:本品苦寒,既能清解火热毒邪,又能泄降滞气,故为清热解毒,消痈散结之佳品,主治内外热毒疮痈诸证,兼能疏郁通乳,故为治疗乳痈之要药。2、热淋涩痛,湿热黄疸:本品苦、甘而寒,能清利湿热,利尿通淋,对湿热引起的淋证、黄疸等有较好的疗效。3、本品还有清肝明目的作用,以治肝火上炎引起的目赤肿痛。4、西医诊为流行性感冒、上呼吸道感染属于风热表证者,尿路结石、泌尿系感染等属于下焦热盛者。
相关论述:1、《本草经疏》:“蒲公英昧甘平,其性无毒。当是入肝入胃,解热凉血之要药。乳痈属肝经,妇人经行后,肝经主事,故主妇人乳痈肿乳毒,并宜生暖之良。”2、《医林纂要》:“蒲公英点能化热毒,解食毒,消肿核,疗疔毒乳痈,皆泻火安上之功。通乳汁,以形用也。固齿牙,去阳阴热也。人言一茎两花,高尺许,根下大如拳,旁有人形拱抱,捣汁酒和,治噎隔神效。吾所见皆一茎一花,亦鲜高及尺者,然以治噎膈。”3、《本草求真》:“蒲公英,入阳明胃、厥阴肝,凉血解热,故乳痈、乳岩为首重焉。缘乳头属肝,乳房属胃,乳痈、乳岩,多因热盛血滞,用此直入二经,外敷散肿臻效,内消须同夏枯、贝母、连翘、自英等药同治。”4、《本草正义》:“蒲公英,其性清凉,治一切疗疮、痈疡、红肿热毒诸证,可服可敷,颇有应验,而治乳痈乳疗,红肿坚块,尤为捷效。鲜者捣汁温服,干者煎服,一味亦可治之,而煎药方中必不可缺此。”5、《唐本草》:“主妇人乳痈肿。”6、《本草衍义补遗》:“化热毒,消恶肿结核,解食毒,散滞白。”7、《滇南本草》:“敷诸疮肿毒,疥颓癣疮;祛风,消诸疮毒,散瘰疠结核;止小便血,治五淋癃闭,利膀胱。”8、《医林纂要》:“补脾和胃,泻火,通乳汁,治噎膈。”
蒲公英配夏枯草:二者皆为清热之品,均入厥阴肝经,蒲公英清热解毒、疏郁散结、行滞通络;夏枯草善于清肝火、散郁结。二药配用,清热解毒之中寓于化滞散结,清解而不郁遏,使清热解毒、行滞散结之力加强。适用于肝胆热毒、湿热郁结之黄疸、胁肋疼痛;肝经实火、热毒内蕴之咽喉肿痛、目赤肿痛;火热邪毒郁结所致的疔疮痈肿、瘰疬痰核、乳痈初起等。
(2)王不留行:
功能:活血通经,下乳消痈,利尿通淋。
主治:1、血瘀经闭、痛经、难产:本品善于通利血脉,活血通经,走而不守。2、产后乳汁不下,乳痈肿痛:本品归肝、胃经,走血分,苦泄宣通,行而不留,能行血脉,通乳汁。3、热淋,血淋,石淋:本品性善下行,能活血利尿通淋。
相关论述:1、《神农本草经》:“主金疮,止血逐痛。出刺,除风痹内寒。”2、《本草纲目》:“利小便。”“王不留行能走血分,乃阳明冲任之药,俗有‘穿山甲、王不留,妇人服了乳长流’之语,可见其性行而不住也。”
王不留行配黄芪:王不留行善能通经下乳;黄芪善能补中益气。两药伍用,寓通于补,能补气通经下乳。适用于产后气血亏虚,乳汁稀少。
(3)瓜蒌:
性味:甘、微苦、寒。归经:归肺、胃、大肠经。
功能主治:清热涤痰,宽胸散结,润燥滑肠。用于肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肺痈,肠痈肿痛,大便秘结。
(4)漏芦:
功能:清热解毒,消痈散结,通经下乳,舒筋通脉。
主治:1、乳痈肿痛,瘰疬疮毒:本品苦寒降泄,故有清热解毒、消痈散结之效,又因其能通经下乳,故尤为治乳痈之良药。2、乳汁不下:本品味苦降泄,有良好的通经下乳之功,为产后乳汁不通的常用药。3、湿痹拘挛:本品性善通利,有舒筋通脉活络之功。
相关论述:1、《神农本草经》:“主皮肤热,恶疮疽痦,湿痹,下乳汁。”2、《本经逢原》:“漏芦,《本经》治热毒恶疮,下乳汁,以其能利窍也,为消毒排脓杀虫要药。”
临床应用:1、治乳痈肿痛,常与瓜蒌、蛇蜕同用,如漏芦散(《和剂局方》);治热毒壅聚,痈肿疮毒,常与大黄、连翘、紫花地丁等药同用,如漏芦汤(《千金方》);治痰火郁结,瘰疬欲破者,可与海藻、玄参、连翘等药同用,如漏芦汤(《圣济总录》);治疗湿疹湿疮、皮肤瘙痒等,《本草汇言》又以漏芦与荆芥、苦参、白鲜皮、当归等浸酒蒸饮。2、治乳络塞滞,乳汁不下,乳房胀痛,欲作乳痈,常与穿山甲、王不留行等药同用;若为气血亏虚,乳少清稀者,当与黄芪、鹿角胶等同用。
(5)连翘:
功能:清热解毒,消肿散结,疏散风热。
主治:1、疮痈肿毒,瘰疬痰核:本品苦寒,主入心经,既能清心火,又能消散痈肿,固有“疮家圣药”之称。2、风热外感,温病初起:本品苦能清泄,寒能清热,入心、肺二经,长于清心火,散上焦风热。3、热淋涩痛:本品苦寒通降,兼有清心利尿之功。4、西医诊为流行性感冒、上呼吸道感染属于风热表证者,尿路结石、泌尿系感染等属于下焦热盛者。
相关论述:1、《神农本草经》:“主寒热,鼠瘘、瘰疬、痈肿、恶疮、瘿瘤、结热、蛊毒。”2、《珍珠囊》:“连翘之用有三:泻心经客热,一也;去上焦诸热,二也,为疮家圣药,三也。”
相关配伍:本品配以银花、薄荷、荆芥、甘草,则散风清热;配以玄参、麦冬、青莲心、竹叶卷心等,则清心泄热;配以银花、蒲公英、紫花地丁、赤芍等,则解毒消痈;配以玄参、夏枯草、贝母等,则散结消瘰。
(6)夏枯草:
功能:清热泻火,明目,散结消肿。
主治:1、目赤肿痛,头痛眩晕,自珠夜痛:本品苦寒主入肝经,善泻肝火以明目。用治肝火上炎,目赤肿痛,肝阴不足,目珠疼痛,至夜尤甚者。2、瘰疬,瘿瘤:本品味辛能散结,苦寒能泄热,治肝郁化火,痰火凝聚之瘰疬,瘿瘤。3、乳痈肿痛:本品既能清热泻肝火,又能散结消肿,可治乳痈肿痛,热毒疮疡。4、西医诊为急性结膜炎、沙眼、周期性偏头痛、紧张性头痛、丛集性头痛属于肝火上炎者,颈部淋巴结核、甲状腺疾病、体表良性肿瘤属于痰火郁结者,急性乳腺炎属于肝经郁热者。
有关论述:1、《神农本草经》:“主寒热、瘰疬、鼠瘘、头疮,破癓,散瘿结气,脚肿湿痹。”2、《本草纲目》:“夏枯草治目疼,用砂糖水浸一夜用,取其能解内热,缓肝火也。楼全善云,夏枯草治目珠疼至夜则甚者,神效,或用苦寒药点之反甚者,亦神效。盖目珠连目本,肝系也,属厥阴之经。夜甚及点苦寒药反甚者,夜与寒亦阴故也。夏枯禀纯阳之气,补厥阴血脉,故治此如神,以阳治阴也。”3、《重庆堂笔记》:“夏枯草,微辛而甘,故散结之中,兼有和阳养阴之功,失血后不寐者服之即寐,其性可见矣。陈久者尤甘,入药为胜。”
(7)天花粉:
功能:清热泻火,生津止渴,消肿排脓。
主治:1、热病烦渴:本品甘寒,既能清肺胃二经实热,又能生津止渴,故常用治热病烦渴,燥伤肺胃,咽干口渴。2、肺热燥咳:本品既能泻火以清肺热,又能生津以润肺燥,用治燥热伤肺,干咳少痰、痰中带血等肺热燥咳证,燥热伤肺,气阴两伤之咳喘咯血。3、内热消渴:本品善清肺胃热、生津止渴,可用治积热内蕴,化燥伤津之消渴证,内热消渴,气阴两伤者。4、疮疡肿毒:本品既能清热泻火而解毒,又能消肿排脓以疗疮,用治疮疡初起,热毒炽盛,未成脓者可使消散,脓已成者可溃疮排脓,风热上攻,咽喉肿痛。5、西医诊为上呼吸道感染、支气管炎、支气管扩张、肺炎属于肺热壅盛者,肿瘤、血液病、结缔组织疾病属于阴虚火妄者,内分泌疾病属于热盛津伤者,单纯疱疹、带状疱疹、化脓性感染属于热毒内盛者。
相关论述:1、《本草汇言》:“天花粉,退五脏郁热,如心火盛而舌下口燥,肺火盛而咽肿喉痹,脾火盛而口舌齿肿,痰火盛而咳嗽不宁。若肝火之胁胀走注,肾火之骨蒸烦热,或痈疽已溃未溃,而热毒不散,或五疸身目俱黄,而小水若淋若涩,是皆火热郁结所致。惟此剂能开郁结,降痰火,并能治之。又其性甘寒,善能治渴,从补药而治虚渴,从凉药而治火渴,从气药而治郁渴,从血药而治烦渴,乃治渴之要药也。”2、《日华子本草》:“通小肠,排脓,消肿毒,生肌长肉,消扑损瘀血。治热狂时疾,乳痈,发背,痔痰疮疖。”
天花粉配瓜蒌皮:二药虽同出一物,但作用不尽相同。天花粉功偏降火润燥,生津止渴;瓜蒌皮则偏于利气宽胸,清化热痰。二药配用,具有清热生津、开胸散结之效。适用于肺燥咳嗽,热病伤阴之口干口渴、胸闷气逆等。
(8)紫花地丁:
味苦、辛、寒。归心、肺经。具有清热解毒,凉血消肿,清热利湿的作用,主治疔疮,痈肿,瘰疬,黄疸,痢疾,腹泻,目赤,喉痹,毒蛇咬伤。
用法指导:1.凡各种疔毒痈疮,红肿热痛者,可单用鲜品捣汁服,并用其渣敷患处;或与金银花、蒲公英、野菊花配伍。2.若气血亏虚者,可加入当归、黄芪;若湿热凝结骨痈疼痛高肿者,可与茯苓、车前子、金银花、牛膝同用,以利湿清热。3.凡颈项瘰疬结核者,可与夏枯草、玄参、贝母、牡蛎相合,以散结消肿。
(9)玄参:
功能主治:滋阴,降火,除烦,解毒。治热病伤阴,舌绎烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬,温毒发斑、目赤、白喉、疮毒。
玄参为咸寒之品,质润多液,功能滋阴降火、解毒、利胭。配鲜生地、丹皮、赤芍等,则清热凉血;配大生地、麦冬等,则滋阴增液;配牛蒡子、板蓝根等,则解毒利咽;配大生地、石决明、密蒙花、蝉蜕等,则明目退翳;配牡蛎、贝母、夏枯草等,则散结消瘰;配银花、当归、甘草,则解毒消肿。
(10)知母:
功能:清热泻火,滋阴润燥。
主治:1、热病烦渴:本品味苦甘而性寒质润,苦寒能清热泻火除烦,甘寒质润能生津润燥止渴,善治外感热病,高热烦渴者。2、肺热燥咳:本品主入肺经而长于泻肺热、润肺燥,用治肺热燥咳,常配贝母用,如二母散(《证治准绳》);若配杏仁、莱服子,可治肺燥久嗽气急,如宁嗽煎(《奇方类编》)。3、骨蒸潮热:本品兼入肾经而能滋肾阴、泻肾火、退骨蒸,用治阴虚火旺所致骨蒸潮热、盗汗、心烦者,常配黄柏、生地黄等药用,如知柏地黄丸(《医宗金鉴》)。4、内热消渴:本品性甘寒质润,能泻肺火、滋肺阴,泻胃火、滋胃阴,泻肾火、滋肾阴,可用治阴虚内热之消渴证,常配天花粉、葛根等药用,如玉液汤(《医学衷中参西录》)。5、肠燥便秘:本品功能滋阴润燥,可用治阴虚肠燥便秘证,常配生地黄、玄参、麦冬等药用。6、西医诊为上呼吸道感染、支气管炎、支气管扩张、肺炎属于肺热壅盛者,肿瘤、血液病、结缔组织疾病属于阴虚火旺者,内分泌疾病属于热盛津伤者,功能性便秘、肠道激惹综合征属于肠燥津枯者。
相关论述:1、《神农本草经》:“主消渴热中,除邪气,肢体浮肿,下水,补不足,益气。”2、《用药法象》:“泻无根之肾火,疗有汗之骨蒸,止虚劳之热,滋化源之阴。”3、《本草纲目》:“知母之辛苦寒凉,下则润肾燥而滋阴,上则清肺金而泻火,乃二经气分药也。”
知母配天花粉:知母上能润肺泻火,中能清胃热,下能补肾阴、泻虚火,对虚实之热均有效;天花粉有生津润燥止渴、清热化痰之功。二药相须为用,善清肺胃实热而生津止渴。适用于热病伤津之口干舌燥、烦渴,消渴证,肺痿干咳等。
(11)青皮:
功能:疏肝破气,消积化滞。
主治:1、肝郁气滞证:本品辛散温通,苦泄下行而奏疏肝理气、散结止痛之功。尤宜于治肝郁气滞之胸胁胀痛、疝气疼痛、乳房肿痛。2、气滞脘腹疼痛:本品辛行温通,入胃而行气止痛。3、食积腹痛:本品辛行苦降温通,有消积化滞、和降胃气、行气止痛之功。4、癥瘕积聚,久疟痞块:本品气味峻烈,苦泄力大,辛散温通力强,能破气散结。
相关论述:1、《本草图经》:“主气滞,下食,破积结及膈气。”2、《本草汇言》:“青橘皮,破滞气,削坚积之药也。……此剂苦能泄,辛能散,芳香能消瘴,运行水谷,诚专功也。”
临床应用:1、治肝郁胸胁胀痛,常配柴胡、郁金、香附等。2、治乳房胀痛或结块,常配柴胡、浙贝母、橘叶等。3、治乳痈肿痛,常配瓜蒌皮、金银花、蒲公英等。
(12)香附:
功能:疏肝解郁,调经止痛,理气调中。
主治:1、主要用于肝郁气滞胁痛、腹痛,月经不调,痛经,乳房胀痛,气滞腹痛等。2、西医诊为慢性胃炎、胃十二指肠溃疡、胆囊炎、慢性肝炎、肝硬化、胆石症、慢性胰腺炎、单纯性甲状腺肿、乳腺增生、原发性痛经、继发性痛经、月经不调、卵巢囊肿、盆腔炎等属肝郁气滞者。
相关论述:1、《本草纲目》:利三焦,解六郁,消饮食积聚、痰饮痞满,跗肿腹胀,脚气,止心腹、肢体、头目、齿耳诸痛,……妇人崩漏带下,月候不调,胎前产后百病。”“乃气病之总司,女科之主帅也。2、《本草求真》:香附,专属开郁散气,与木香行气,貌同实异,木香气味苦劣,故通气甚捷,此则苦而不甚,故解郁居多,且性和于木香,故可加减出人,以为行气通剂,否则宜此而不宜彼耳。
(13)黄芪:
功能:健脾补中,升阳举陷,益卫固表,利尿,托毒生肌。
主治:1、脾气虚证:本品甘温,善入脾胃,为补中益气要药。因其能升阳举陷,故长于治疗脾虚中气下陷之久泻脱肛,内脏下垂。本品既能补脾益气,又能利尿消肿,标本兼治,为治气虚水肿之要药。本品又能补气生血,治血虚证亦常与补血药配伍。对脾虚不能统血所致失血证,本品尚可补气以摄血。对脾虚不能布津之消渴,本品能补气生津,促进津液的生成与输布而有止渴之效。2、肺气虚证:本品入肺又能补益肺气,可用于肺气虚弱,咳喘日久,气短神疲者,常与祛痰止咳平喘之品配伍。3、气虚自汗证:脾肺气虚之人往往卫气不固,表虚自汗。本品能补脾肺之气,益卫固表。4、气血亏虚,疮疡难溃难腐,或溃久难敛:本品以其补气之功还能收托毒生肌之效。5、痹证、中风后遗症等气虚而致血滞,筋脉失养,症见肌肤麻木或半身不遂者,亦常用本品补气以行血。6、西医诊为胃下垂、肾下垂、直肠脱垂、子宫脱垂、慢性胃肠炎属脾气虚弱、中气下陷证者,不明发热属气亏血虚,血虚阳浮证者,附件炎、子宫功能性出血、冠心病心绞痛、脑梗死后遗症属气虚血滞证者,糖尿病属气阴不足证者,贫血、营养不良属气血两虚证者,上呼吸道感染、支气管炎属肺气虚弱,表虚不固证者,慢性肾炎、特发性水肿、功能性水肿属脾虚失运,水湿内停证者,植物神经功能失调、免疫功能低下、慢性疖肿属于气虚证者。
相关论述:1、《本草汇言》:补肺健脾,实卫敛汗,驱风运毒之药也。2、《医学衷中参西录》:能补气,兼能升气,善治胸中大气(即宗气)下陷。
黄芪配当归:黄芪补脾肺之气,以益生血之源;当归养心肝之血,以补血和营。两药配伍,可增强益气生血的作用。适用于劳倦内伤、肌热面赤、烦渴、脉虚大乏力及疮疡、血虚发热、诸气血不足等。
(14)当归:
功能:补血活血,调经止痛,润肠通便。
主治:1、主治血虚萎黄,月经不调,经闭痛经,血虚、血滞、血寒诸痛,跌打损伤,风湿痹痛,痈疽疮疡,肠燥便秘等。2、西医诊为贫血属于心肝血虚者,子宫内膜炎、功能性子宫出血、先兆流产、习惯性流产、产后出血属血虚血滞者,肌肉深部脓疡属血虚者,习惯性便秘、老人或产后便秘等属血虚津枯者。
相关论述:1、《神农本草经》:主咳逆上气,温疟寒热洗洗在皮肤中。妇人漏下绝子,诸恶疮疡,金疮。2、《本草纲目》:治头痛,心腹诸痛,润肠胃、筋骨、皮肤,治痈疽,排脓止痛,和血补血。3、《医学启源》:当归,气温味甘,能和血补血,尾破血,身和血。
(15)甘草:
功能:益气补中,润肺止咳,清热解毒,缓急止痛,调和药性。
主治:1、主要用于脾虚倦怠,心虚悸动,咳嗽气喘,痈疽喉痹,药食中毒,脘腹、四肢挛急疼痛等。2、西医诊为慢性胃肠炎、胃痉挛、心律失常属于脾气虚弱证者,气管炎属于肺气虚弱证者,急性咽炎慢性咽炎、食物中毒属于热毒壅盛证者。
甘草配蒲公英:甘草甘平,长于清热解毒,缓急止痛;蒲公英甘寒,善于清热解毒,消痈散结。两药配伍,可增强清热解毒的作用。适用于疮痈肿毒,外伤疮口红肿,内服或外洗均有效。
中兽医认为:奶牛乳房炎发生的原因比较复杂,或因久卧湿地,湿热毒气上蒸侵犯乳房,致使乳络不畅,气血凝滞而引起;或因平时喂养过剩,乳汁过于浓稠,阻塞乳管,乳汁排出不畅,以及泌乳过多,幼畜吸吮不完,或乳牛人工挤奶不完全,产后幼畜死亡,乳汁未能消散,停留乳房,久而化为热毒所致;或因母畜使役负重太过,奔走太急,致使胃热壅盛,胃脉受阻,乳房经气阻塞而致;或因乳头受到咬伤、压伤、踢伤、打伤、邪毒经伤口而入所致;受惊、失子等因素导致肝气郁结,亦可诱发本病。此外,子宫炎等疾病也可继发本病。因此,治则应为:疏肝气、散凝结、清胃热、消肿毒等。本发明以清热解毒、凉血消肿、行气散结、散瘀止痛、疏肝解郁、增强免疫功能为治疗原则。
本发明的原理是:配方中蒲公英、王不留行、瓜蒌、漏芦清热解毒、消痈散结,为君药;连翘、夏枯草、天花粉、紫花地丁、玄参、知母既配合君药加强清热解毒之力,又兼排脓痈、托毒、滋阴,为臣药;青皮、香附疏肝行气,兼有活血之功效,黄芪、当归健脾益气,脾胃气足则气能行津,痰湿得化,为佐药;甘草缓急止痛,调和诸药,为使药。诸药共用,使内湿得清,内热得解,共奏清热解毒、消肿散结、行气活血、增强免疫功能和调节代谢等功效。
相比现有技术,本发明的有益效果在于:
1、本发明由蒲公英、王不留行、瓜蒌、漏芦、连翘、夏枯草、天花粉、紫花地丁、玄参、知母等十五味中药组成,具有清热解毒、消肿散结的功效,临床主要用于治疗奶牛临床型乳房炎。方中蒲公英、王不留行、瓜蒌、漏芦行清热解毒,之效,为君药。连翘、夏枯草、天花粉、紫花地丁、玄参、知母既配合君药加强清热解毒之力,又兼排脓痈、托毒、滋阴,为臣药。同时佐以青皮、香附疏肝行气,黄芪、当归理气调中,扶正气补中气,益卫固表,加强托毒生肌之力,增强消肿散结之效;配甘草,甘草缓急止痛,调和诸药。诸药配伍,标本兼治、平衡阴阳、扶正祛邪,共奏清热解毒、散结消痈、活络通乳、行气活血等功效;2、本发明中兽药组方诸药见本草各典,药效明确,不失为治疗奶牛乳房炎的有效组方。蒲公英配夏枯草,使清热解毒、行滞散结之力加强;王不留行配黄芪,寓通于补,能补气通经下乳;漏芦与瓜蒌同用治乳痈肿痛,与连翘、紫花地丁同用治热毒壅聚,痈肿疮毒,与玄参、连翘同用治痰火郁结,瘰疬欲破,与王不留行同用治乳络塞滞、乳汁不下、乳房胀痛、欲作乳痈,与黄芪等同用治气血亏虚,乳少清稀;连翘配以甘草有散风清热之效,配以玄参有清心泄热之效,配以蒲公英、紫花地丁有解毒消痈之效,配以玄参、夏枯草有散结消瘰之效;天花粉配瓜蒌皮具有清热生津、开胸散结之效;紫花地丁与蒲公英配伍可治疗各种疔毒痈疮、红肿热痛,若气血亏虚,可加入当归、黄芪;玄参配夏枯草,则散结消瘰;玄参配当归、甘草,则解毒消肿;知母配天花粉,善清肺胃实热而生津止渴;青皮配香附可治肝郁胸胁胀痛,配瓜蒌皮、蒲公英可治乳痈肿痛;黄芪配当归,可增强益气生血的作用;甘草配蒲公英配伍,可增强清热解毒的作用。
3、本发明中兽药组方合理,制备方法简单,制成口服液,使用更加方便,吸收利用迅速。本发明采用纯天然中草药,含有多种生物有效成分,具有抗菌、消炎、低毒、无残留、不易产生耐药性的特点;原料药易得,价格低廉且安全、无残留,对奶牛及人体无任何毒副作用,缩短恢复期,保证奶牛的健康及产奶量。
4.本发明中兽药口服液,既可用于“未病先防”,预防奶牛乳房炎的发生;也可用于“既病防变”,治疗奶牛乳房炎。预防和治疗奶牛乳房炎的效果好,也能提高奶牛产奶量。
具体实施方式
以下实施例用于说明本发明,但不用来限定本发明的保护范围。若未特别指明,实施例中所用技术手段为本领域技术人员所熟知的常规手段。下述实施例中的试验方法,如无特别说明,均为常规方法。
实施例一
本发明防治奶牛乳房炎的中药口服液,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英15g、王不留行8g、瓜蒌9g、漏芦8g,连翘8g、夏枯草7g、天花粉8g、紫花地丁7g、玄参3g、知母3g、青皮3g、香附3g、黄芪8g、当归8g、甘草2g,共计100g。
口服液制备方法:
(1)制取浓缩药液:首先按上述重量称取以上十五味中药,加入500mL纯化水,冷水浸20min,煎煮三次,每次均加热煎煮20min,将三次煎煮液合并后用80目滤网过滤,在70℃条件下减压浓缩至相对密度1.05-1.10,再向浓缩液内添加95%乙醇,边加边搅拌,至乙醇含量达到40%,静置12h后,取上清液80目滤网过滤,得水提醇沉液,在70℃条件下减压浓缩至相对密度1.05-1.10,即为浓缩药液,且在提取上清液过程中同时回收乙醇;
(2)添加辅料制取成品口服液:将浓缩药液加入0.3g甜菊素、0.06g尼泊金乙酯,搅拌均匀后,离心取上清液,加纯化水至100mL,搅拌均匀,分装,105℃流通蒸汽灭菌30min,即得用于防治奶牛乳房炎的中药口服液。
实施例二
本发明防治奶牛乳房炎的中药口服液,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英8g、王不留行15g、瓜蒌9g、漏芦9g,连翘5g、夏枯草4g、天花粉6g、紫花地丁8g、玄参5g、知母4g、青皮4g、香附5g、黄芪7g、当归7g、甘草4g,共计100g。
口服液制备方法:
(1)制取浓缩药液:首先按上述重量称取以上十五味中药,加入800mL纯化水,冷水浸40min,煎煮三次,每次均加热煎煮40min,将三次煎煮液合并后用100目滤网过滤,在80℃条件下减压浓缩至相对密度1.05-1.10,再向浓缩液内添加95%乙醇,边加边搅拌,至乙醇含量达到50%,静置18h后,取上清液100目滤网过滤,得水提醇沉液,在80℃条件下减压浓缩至相对密度1.05-1.10,即为浓缩药液,且在提取上清液过程中同时回收乙醇;
(2)添加辅料制取成品口服液:将浓缩药液加入0.4g甜菊素、0.08g尼泊金乙酯,搅拌均匀后,离心取上清液,加纯化水至100mL,搅拌均匀,分装,105℃流通蒸汽灭菌45min,即得用于防治奶牛乳房炎的中药口服液。
实施例三
本发明防治奶牛乳房炎的中药口服液,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英9g、王不留行12g、瓜蒌8g、漏芦9g,连翘6g、夏枯草7g、天花粉7g、紫花地丁8g、玄参5g、知母3g、青皮4g、香附4g、黄芪8g、当归7g、甘草3g,共计100g。
口服液制备方法:
(1)制取浓缩药液:首先按上述重量称取以上十五味中药,加入1000mL纯化水,冷水浸60min,煎煮三次,每次均加热煎煮60min,将三次煎煮液合并后用120目滤网过滤,在90℃条件下减压浓缩至相对密度1.05-1.10,再向浓缩液内添加95%乙醇,边加边搅拌,至乙醇含量达到60%,静置24h后,取上清液120目滤网过滤,得水提醇沉液,在90℃条件下减压浓缩至相对密度1.05-1.10,即为浓缩药液,且在提取上清液过程中同时回收乙醇;
(2)添加辅料制取成品口服液:将浓缩药液加入0.5g甜菊素、0.1g尼泊金乙酯,搅拌均匀后,离心取上清液,加纯化水至100mL,搅拌均匀,分装,105℃流通蒸汽灭菌45min,即得用于防治奶牛乳房炎的中药口服液。
对比例1
与实施例3相比,不含蒲公英和王不留行,其他与实施例3相同。
对比例2
与实施例3相比,不含夏枯草和玄参,其他与实施例3相同。
对比例3
与实施例3相比,不含青皮和黄芪,其他与实施例3相同。
对比例4
与实施例3相比,知母20份,香附20份,其他与实施例3相同。
对比例5
与实施例3相比,青皮20份,甘草20份,其他与实施例3相同。
试验例1
在河南某牛场,选取450头患乳房炎奶牛,随机分为9组,采用相同的饲喂方法。第1组采用实施例3制得的中兽药口服液,共50头,150mL/日,连用7天;第2组抗生素乳头灌注,共50头,患病乳区灌注青霉素钠160万单位、链霉素100万单位,每天2次,连用7天;第3组联合治疗,共50头,采用本发明中药口服液和抗生素灌注结合,连用7天;第4组采用对比例1制得的中兽药口服液,共50头,150mL/日,连用7天;第5组采用对比例2制得的中药口服液,共50头,150mL/日,连用7天;第6组采用对比例3制得的中药口服液,共50头,150mL/日,连用7天;第7组采用对比例4制得的中药口服液,共50头,150mL/日,连用7天;第8组采用对比例5制得的中药口服液,共50头,150mL/日,连用7天;第9组不作任何治疗处理,共50头,观察7天。根据临床症状和乳汁质量的改变综合判断药物的疗效,并计算各组乳房炎奶牛7d内的治愈率、有效率和无效率。
临床痊愈:乳房红、肿、热、痛、硬结消失,牛乳中体细胞数正常,奶产量回升,食欲、体温、精神等均恢复正常。
有效:乳房红肿热痛明显好转,乳房肿块显著减少,发热症状消失,牛乳中体细胞数基本正常,乳汁无凝块或少量奶块,奶产量回升但没有达到发病前水平。
无效:乳房红、肿、热、痛、硬结无明显改善或更严重,牛乳中体细胞数超标,奶产量下降。
结果见表1。
表1中药口服液治疗奶牛乳房炎效果
通过表1发现:(1)本发明治疗奶牛乳房炎的中药口服液,可有效治疗奶牛乳房炎,疗效确切,效果良好;(2)本发明治疗奶牛乳房炎的中药口服液,与西药合用,与单一用药相比,更能提高治愈率和有效率;(3)本发明治疗奶牛乳房炎的中药口服液,组方合理。实施例和对比例1、对比例2、对比例3相比,如果缺失本发明配方中的某药材,会导致药效降低;(4)本发明治疗奶牛乳房炎的中药口服液,组方合理。实施例3和对比例4、对比例5相比,所用药量相差较大,但效果相差并不明显。
试验例2
在河南某牛场,选取200头健康奶牛,随机分为4组,采用相同的饲喂方法。试验结束的第61天,根据临床症状和产奶量的改变综合判断药物的疗效。第1组采用实施例1制得的中药口服液,共50头,50mL/日,连用5天,每月使用2次;第2组采用实施例2制得的中药口服液,共50头,50mL/日,连用5天,每月使用2次;第3组采用实施例3制得的中药口服液,共50头,50mL/日,连用5天,每月使用2次;第4组不作任何治疗处理,共50头。结果见表2和表3。
表2对预防乳房炎发病率的影响
组别 | 总头数 | 两个月后患乳房炎头数 | 两个月后乳房炎发病率 |
1 | 50 | 2 | 4% |
2 | 50 | 1 | 2% |
3 | 50 | 2 | 4% |
4 | 50 | 6 | 16% |
表3对产奶量的影响
组别 | 总头数 | 试验前产奶量(kg/头/d) | 试验后产奶量(kg/头/d) |
1 | 50 | 17.5 | 19.7 |
2 | 50 | 16.8 | 18.2 |
3 | 50 | 17.9 | 19.5 |
4 | 50 | 17.3 | 17.1 |
由表2和表3可以看出,中药组对奶牛乳房炎的预防有较好的作用,也能提高奶牛产奶量。
综上所述,本发明中药口服液对奶牛乳房炎有预防和治疗作用,同时可增强奶牛泌乳性能,提高奶产量。
以上所述之实施例,只是本发明的较佳实施例而已,仅仅用以解释本发明,并非限制本发明实施范围,对于本技术领域的技术人员来说,当然可根据本说明书中所公开的技术内容,通过置换或改变的方式轻易做出其它的实施方式,故凡在本发明的原理上所作的变化和改进等,均应包括于本发明申请专利范围内。
Claims (3)
1.一种防治奶牛乳房炎的中药口服液,其特征在于,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英8-15份、王不留行8-15份、瓜蒌6-9份、漏芦6-9份,连翘4-8份、夏枯草4-8份、天花粉4-8份、紫花地丁4-8份、玄参3-5份、知母3-5份,青皮3-5份、香附3-5份,黄芪4-8份、当归4-8份,甘草2-4份。
2.根据权利要求1所述的一种防治奶牛乳房炎的中药口服液,其特征在于,每100mL所述口服液由如下重量份的组分和辅料制成:蒲公英8份、王不留行15份、瓜蒌9份、漏芦9份,连翘5份、夏枯草4份、天花粉6份、紫花地丁8份、玄参5份、知母4份、青皮4份、香附5份、黄芪7份、当归7份、甘草4份。
3.权利要求1~2任一项所述的一种防治奶牛乳房炎的中药口服液的制备方法,其特征在于,包括以下步骤:
称取权利要求1~2所述的中药组分,加入5-10倍纯化水,冷水浸20-60min,煎煮三次,每次均加热煎煮20-60min,将三次煎煮液合并并用80-120目滤网过滤,然后在70-90℃条件下减压浓缩至相对密度1.05-1.10,向浓缩液内添加95%乙醇,边加乙醇边搅拌,至乙醇含量达到40%-60%,静置12-24h后,取上清液用80-120目滤网过滤,得水提醇沉液,最后在70-90℃条件下减压浓缩至相对密度1.05-1.10,得浓缩药液;
向浓缩药液加入0.2-0.5g甜菊素、0.05-0.1g尼泊金乙酯,搅拌均匀后,离心取上清液,加纯化水至100mL,搅拌均匀,分装,105℃流通蒸汽灭菌30-60min,即得治疗奶牛乳房炎的中药口服液。
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