CN116269928B - Intraocular lens with combined smooth diffractive profile - Google Patents
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- 230000003287 optical effect Effects 0.000 claims abstract description 70
- 238000013461 design Methods 0.000 claims abstract description 37
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 5
- -1 acrylic ester Chemical class 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 230000001276 controlling effect Effects 0.000 claims description 2
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- 230000000737 periodic effect Effects 0.000 abstract description 10
- 238000012545 processing Methods 0.000 abstract description 5
- 238000013316 zoning Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 9
- 230000004075 alteration Effects 0.000 description 6
- 238000002513 implantation Methods 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 210000001747 pupil Anatomy 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000012938 design process Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005315 distribution function Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1654—Diffractive lenses
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Abstract
The invention belongs to the technical field of intraocular lens, and particularly relates to an intraocular lens with a combined smooth diffraction profile. It comprises the following steps: a lens body and a support tab; the lens body includes a base lens and an optical surface including a first optical surface and a second optical surface, the first optical surface or the second optical surface being provided with a diffraction profile thereon, the diffraction profile being combined by a plurality of diffraction profile areas, the plurality of diffraction profile areas satisfying a smooth phase distribution. The artificial lens designs the diffraction profile area by using a smooth continuous phase function to improve diffraction efficiency, and combines in a zoning or periodic alternating mode on the basis of reducing processing difficulty so as to obtain more optimized parameters, avoid using negative pole diffraction orders and obtain better design results.
Description
Technical Field
The invention belongs to the technical field of intraocular lens, and particularly relates to an intraocular lens with a combined smooth diffraction profile.
Background
With advances in science and surgical technology, the risk of intraocular lens (IOL) implantation surgery and subsequent complications continue to decrease, which gradually becomes the primary means of treating cataracts. The first most implanted intraocular lenses were monofocal intraocular lenses, providing clear distance vision. Patients who choose to implant monofocal IOLs often require additional vision correction means, such as presbyopic glasses or contact lenses, to accomplish the task of near and intermediate vision.
In order to achieve vision levels closer to that of healthy eyes, intraocular lenses of the optical performance class such as multifocal or extended depth of focus have emerged in recent years. These new intraocular lenses are mostly realized by refractive-diffractive hybrid designs, with additional diffractive profile or zoned designs that enable the basic monofocal IOL to be modified into an IOL of corresponding optical performance. Conventional diffractive intraocular lenses typically employ apodized and saw-tooth shaped discontinuous diffractive profile designs that suffer from limited diffraction efficiency utilization and the discontinuity also makes the performance impact of processing more pronounced.
The technical problem is solved by an intraocular lens designed based on a smooth diffraction profile, such as the prior publication CN108938144a, which uses a phase function designed based on an optimal three beam splitter, providing a smooth and continuous diffraction structure and improving diffraction efficiency. However, the design in the patent is only suitable for three-focus design, and no artificial lens design for expanding the optical performance category such as focal depth, single Jiao Zengjiang and the like is mentioned; meanwhile, the designed phase function is still close to an optimal three-beam splitter, on one hand, the optimization parameters are limited, on the other hand, negative-order diffraction orders are used when the three-focus intraocular lens is designed, chromatic aberration is greatly improved, and the optical performance under the multi-color light after the lens is implanted into a human eye is greatly influenced.
Disclosure of Invention
In order to solve the problems, the invention respectively performs purposeful optimization on each diffraction profile area based on the used smooth phase distribution function, combines the optimized diffraction profile areas in a zonal or periodic alternating mode to obtain a final diffraction profile, and superimposes the final diffraction profile on a lens with certain basic focal power to obtain the intraocular lens with optical properties such as multiple focuses or extended focal depth.
In order to achieve the above purpose, the present invention may adopt the following technical scheme:
The present invention provides an intraocular lens with a combined smooth diffractive profile comprising: a lens body and a support tab; the lens body includes a base lens and an optical surface including a first optical surface and a second optical surface, the first optical surface or the second optical surface being provided with a diffraction profile thereon, the diffraction profile being combined by a plurality of diffraction profile areas, the plurality of diffraction profile areas satisfying a smooth phase distribution.
The beneficial effects of the invention include:
(1) The intraocular lens with combined smooth phase distribution provided by the invention designs the diffraction profile area by using the smooth continuous phase function to improve the diffraction efficiency, and combines in a zoning or periodic alternating mode on the basis of reducing the processing difficulty so as to obtain more optimized parameters, avoid using negative pole diffraction orders and obtain better design results;
(2) According to the invention, the designed combined smooth diffraction profile is superimposed on the basic optical lens, each diffraction profile area can be respectively optimized according to the design target on the premise of providing basic focal power, corresponding parameter combinations are obtained, and after the smooth diffraction profile areas are combined, optical performances such as multiple focuses, expanded focal depths or single Jiao Zengjiang can be realized.
Drawings
FIG. 1 is a diagram of an intraocular lens structure with a combined smooth phase distribution according to the present invention;
FIG. 2 is a schematic view of a zonal combined intraocular lens diffractive profile according to example 1 of the present invention;
FIG. 3 is a plot of a zonal combined trifocal intraocular lens diffractive profile according to example 1 of the present invention;
FIG. 4 is a plot of the defocus MTF of a zoned combined trifocal intraocular lens of example 1 of the present invention;
FIG. 5 is a schematic view of a periodic alternating combination intraocular lens diffraction profile according to example 2 of the present invention;
FIG. 6 is a graph of diffraction profiles of a periodically alternating combined single focus enhanced intraocular lens according to example 2 of the present invention;
FIG. 7 is a graph of the defocus MTF of a periodically alternating combination single focus enhanced intraocular lens of example 2 of the present invention;
In the figure, 1: a lens body; 2: a first optical surface; 3: a second optical surface; 4: a diffraction profile; 5: a support loop; 6: the diffraction profile of the first zoned diffraction profile is sagittal; 7: the diffraction profile of the second zone diffraction profile is sagittal; 8: the diffraction profile of the first alternating diffraction profile is sagittal; 9: the diffraction profile of the second alternating diffraction profile is sagittal.
Detailed Description
The examples are presented for better illustration of the invention, but the invention is not limited to the examples. Those skilled in the art will appreciate that various modifications and adaptations of the embodiments described above are possible in light of the above teachings and are intended to be within the scope of the invention.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. Unless the context clearly differs, singular forms of expression include plural forms of expression. As used herein, it is understood that terms such as "comprising," "having," "including," and the like are intended to indicate the presence of a feature, number, operation, component, part, element, material, or combination. The terms of the present invention are disclosed in the specification and are not intended to exclude the possibility that one or more other features, numbers, operations, components, elements, materials or combinations thereof may be present or added. As used herein, "/" may be interpreted as "and" or "as appropriate.
An embodiment of the present invention provides an intraocular lens with a combined smooth diffraction profile, referring to fig. 1, comprising: a lens body and a support tab; the lens body includes a base lens and an optical surface including a first optical surface and a second optical surface, the first optical surface or the second optical surface being provided with a diffraction profile thereon, the diffraction profile being combined by a plurality of diffraction profile areas, the plurality of diffraction profile areas satisfying a smooth phase distribution.
The diffraction profile of the combination of the plurality of diffraction profile areas is located on the surface of the base lens and is connected with the surface of the base lens, namely, the surface of the lens main body 1 comprises a region provided with the diffraction profile and a region not provided with the diffraction profile, and the region not provided with the diffraction profile is the same as the base lens, so that the profile height of the even aspheric surface is satisfied.
Preferably, in the intraocular lens with a combined smooth diffraction profile, the plurality of diffraction profile zone combinations comprise zonal combinations or periodic alternating combinations.
Preferably, in any of the above intraocular lenses having a combined smooth diffraction profile, the first optical surface and the second optical surface are both even-order aspherical surfaces, and the profile height z (r) of the even-order aspherical surfaces satisfies the following formula:
Where c is the inverse of the radius of curvature of the even aspheric surface, k is the conic coefficient of the even aspheric surface, r is the radial distance from the optical axis to a point on the surface, α i is the aspheric surface high-order term coefficient, and ρ is the normalized radial coordinate.
Preferably, in any of the above intraocular lenses having a combined smooth diffraction profile, the base lens has an edge thickness of 0.2mm to 0.3mm, such as 0.25mm, and a center thickness of 0.7mm to 1.2mm, such as 0.9mm or 1.1mm, etc. The diameter of the diffraction profile optical zone, i.e. the zone of the lens body surface where the diffraction profile is provided, is 6mm.
The center thickness of the base lens is the thickness of the lens body (the thickness of the lens body is the thickness of the lens body at the position of the optical axis thereof).
Preferably, in any of the above intraocular lenses having a combined smooth diffraction profile, after the diffraction profile is superimposed, various values of the diffraction profile parameters are used to achieve various types of optical performance including, but not limited to, multifocal, extended depth of focus, etc. For example, the total surface profile height Z totol of the second optical surface may satisfy the following equation:
Ztotol＝Z(r)+h(r)，
Wherein Z (r) is the profile height of the even aspherical surface; h (r) is the height of the diffraction profile; r is the radial distance of the optical axis to a point on the plane.
Preferably, in the above intraocular lens with a combined smooth diffraction profile,
Wherein lambda is the design wavelength, n 2 is the refractive index of the artificial lens, n 1 is the refractive index of the medium surrounding the artificial lens,Is the phase function corresponding to the diffraction profile.
Preferably, in any of the above intraocular lenses having a combined smooth diffraction profile, the phase function corresponding to the diffraction profile region satisfies the following formula:
Wherein Po is a parameter of the phase function for adjusting the height of the diffraction profile, α is a sine amplitude regulation parameter, so is a amplitude regulation parameter of the arctangent function, bo and Co are regulation parameters of the phase function for the performance ratio between focal planes, and T is the period of the phase function.
Preferably, in any of the above intraocular lenses having a combined smooth diffraction profile,
The diffraction profile in the case of zone combinations satisfies the following formula:
wherein, P i-1 is the demarcation point of the ith block partition, which is the smooth phase function corresponding to the ith block diffraction profile area;
the diffraction profile in the case of periodic alternating combinations satisfies the following formula in the period:
wherein, For the smooth phase function corresponding to the i-th diffraction profile area, p i-1 is the demarcation point of the i-th diffraction profile area, and T is the total period of the periodic alternating combination diffraction profile.
Preferably, in any of the above intraocular lenses having a combined smooth diffraction profile, the lens body satisfies one or more of the following conditions: (a) The lens body is prepared from hydrophobic acrylic ester, hydrophilic acrylic ester or polymethyl methacrylate; (b) the wavelength of the lens body is 555nm.
The refractive index of the material of the intraocular lens of the present invention is set to be between 1.46 and 1.55, that is, the refractive index of the material of the intraocular lens of the present invention is 1.46 or more and 1.55 or less, preferably hydrophobic acrylate, hydrophilic acrylate or polymethyl methacrylate.
The base lens only uses the even aspherical surface as the design surface type, and the rear surface is guaranteed not to use the high-order even aspherical surface item, so that the design difficulty is reduced. Meanwhile, each diffraction profile area is smoothly and continuously distributed, so that the energy loss is reduced, the optical performance is improved, and the imaging quality is more excellent.
Preferably, in any of the above intraocular lenses having a combined smooth diffraction profile, the intraocular lens base power ranges from +10d to +30d. The basic focal power of the intraocular lens is determined by the basic surface curvature radius, and the intraocular lens can realize optical properties such as multifocal, expansion of focal depth and the like by superposing and combining smooth diffraction profiles.
In the intraocular lens with the combined smooth diffraction profile, each diffraction profile area is initially optimally designed according to the characteristic of flexibly regulating and controlling focal energy based on the improved smooth phase function, so that the negative-pole diffraction order is avoided as much as possible, and meanwhile, the diffraction efficiency is improved as much as possible. Further, each diffraction profile area is combined in a zoning or periodic alternating combination mode to obtain a final diffraction profile, and the final diffraction profile is added on a basic lens with certain optical power based on even-order aspheric surface design to obtain the intraocular lens with optical properties of multiple focuses, expanded focal depth and the like. The obtained design result keeps the continuous characteristic of designing the diffraction profile by smooth phase distribution, and has low processing difficulty and light optical pollution phenomenon. Meanwhile, as the number of optimized parameters is increased, a design result with more excellent optical performance and smaller chromatic aberration can be obtained, and more excellent postoperative visual quality is provided for patients.
For a better understanding of the present invention, the content of the present invention is further elucidated below in connection with the specific examples, but the content of the present invention is not limited to the examples below.
Example 1 zonal combination intraocular lens
(1) Intraocular lens design
In the implementation of the invention, the PMMA material with the refractive index of 1.492 is selected as the material of the supporting tab connected with the effective optical part, the design wavelength of the intraocular lens is 555nm, and the diffraction profile is superposed on the second optical surface (rear optical surface); the intraocular lens had a base power of +20d and an add power of +1.75d, +3.50d with a three-focus optical performance after addition of the combined smooth diffraction profile.
And (3) optimizing to obtain an even aspherical lens main body with the corresponding basic focal power of +20D, wherein the even aspherical lens obtained by optimization is a biconvex lens with the diameter of 6mm, the effective optical area of 6mm and the center thickness of 0.9 mm. Wherein the radius of curvature of the first optical surface (front optical surface) is-15.600 mm, k= -15.365, and the radius of curvature of the second optical surface (rear optical surface) is-15.600 mm; the even aspherical coefficients of both optical surfaces were 0.
The designed intraocular lens needs to avoid using negative pole order diffraction order on the basis of realizing three-focus optical performance, thereby achieving the purpose of reducing chromatic aberration. According to the design objective, the design of the intraocular lens is performed in the form of a combination of zones (i=2) (see fig. 2), the first zone diffraction profile being a bifocal diffraction profile with an add power of +1.75d and the second zone diffraction profile being a bifocal diffraction profile with an add power of +3.50d.
According to the design objective, the first zone diffraction profile gave the design result of po=0.900, so=0.800, co=0.450, the second zone diffraction profile gave the design result of po=0.900, so=0, co=0.450, and the demarcation point of the two zones was p 1 =0.65 mm. The parameter combinations are substituted into the phase function, and the resulting combined smooth diffraction profile sagittal curve is shown in fig. 3.
In the design process, the defocus optical transfer function (Through Focus Modulation Transfer Function, TF MTF) of the central view field under monochromatic light (555 nm) and white light (475 nm-645 nm) is used as an evaluation index; all evaluations were performed at a pupil size of 3 mm.
(2) Intraocular lens Performance study
The designed combined smooth phase distribution trifocal intraocular lens was placed into a Model2 eye Model conforming to international standard ISO11979-2 for optical performance analysis, and its sub TF MTF curve (3 mm pupil size, 50 lp/mm) was plotted over the central field of view, and the results are shown in fig. 4. It can be seen that the intraocular lens exhibits the desired trifocal performance characteristics and each focal point has a greater depth of focus, conforming to the design requirements for providing multiple distance good vision after implantation. By comparing the performances of monochromatic light and white light, the peak value of the MTF of the three focuses is reduced at a lower level, and the condition that the peak value is greatly influenced by chromatic aberration does not occur, so that the peak value is consistent with expectations.
The designed tri-focal intraocular lens with combined smooth phase distribution has less influence of chromatic aberration on the basis of providing excellent tri-focal performance, and a patient can expect to obtain more excellent postoperative vision after actual implantation. The design results similar to those of example 1 can also be obtained by periodically alternating combinations. Compared with the traditional discontinuous diffraction profile intraocular lens, the intraocular lens has the advantages of low processing difficulty, insignificant optical pollution phenomenon and the like. According to the same design flow, the zonal combined smooth phase distribution intraocular lens with expanded focal depth optical performance can be obtained.
Example 2 periodic alternating combination intraocular lenses
(1) Intraocular lens design
In the embodiment of the invention, the PMMA material with the refractive index of 1.492 is also selected as the material of the intraocular lens, and the design wavelength of the intraocular lens is 555nm, and the diffraction profile is superposed on the rear optical surface, as the material of the supporting tab connected with the effective optical part.
The designed artificial lens with combined smooth phase distribution has the basic focal power of +20D, and the single focus enhanced optical performance is obtained after the combined smooth diffraction profile is added, so that the parameters of the even aspherical lens main body 1 with the corresponding basic focal power of +20D are obtained in an optimized mode and are the same as those of the embodiment 1.
The designed artificial lens with combined smooth phase distribution also needs to avoid using negative pole order diffraction order on the basis of realizing single focus to enhance optical performance, thereby achieving the purpose of reducing chromatic aberration. According to the design objective, the design of the intraocular lens is performed with a diffraction profile in the form of a combination of periodic alternations (i=2) (see fig. 5), the first alternate diffraction profile being a bifocal diffraction profile with an add power of +0.90D and the second alternate diffraction profile being a bifocal diffraction profile with an add power of +1.80D. According to the design objective, the first alternate diffraction profile gives a design result of po=0.650, so=0.900, co=0.200, the second alternate diffraction profile gives a design result of po=0.650, so=0.900, co=0.200, the demarcation point of the two zones is p 1 =1.22 mm, and the total period t=2.444 mm 2; the parameter combinations are substituted into the phase function, and the resulting combined smooth diffraction profile sagittal curve is shown in fig. 6.
(2) Intraocular lens Performance study
The designed combined smooth phase distribution trifocal intraocular lens was placed in a Model2 eye Model conforming to international standard ISO11979-2 for optical performance analysis, and its sub TF MTF curve (3 mm pupil size, 50 lp/mm) was plotted over the central field of view, and the results are shown in fig. 7. It can be seen that the intraocular lens exhibits the desired single focal enhanced performance characteristics, with the addition of a certain intermediate distance vision based on providing better distance vision approximating that of a single focal intraocular lens; compared with the performance of monochromatic light and white light, the focal depth is kept at a certain level, and the characteristics of a single Jiao Zengjiang can be still reflected.
Finally, it is noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered by the scope of the claims of the present invention.
Claims (7)
1. An intraocular lens having a combined smooth diffractive profile, comprising: a lens body and a support tab; the lens body comprises a basic lens and an optical surface, the optical surface comprises a first optical surface and a second optical surface, a diffraction profile is arranged on the first optical surface or the second optical surface, the diffraction profile is formed by combining a plurality of diffraction profile areas, and the plurality of diffraction profile areas meet smooth phase distribution; the plurality of diffraction profile zone combinations includes a zone combination;
The diffraction profile in the case of zone combinations satisfies the following formula:
；
wherein, For the smooth phase function corresponding to the i-th block diffraction profile zone,/>The boundary point of the i-th block partition, r is the radial distance from the optical axis to a point on the plane; i=2;
the diffraction profile region corresponds to a phase function satisfying the following formula:
，
wherein, Parameter for adjusting diffraction profile height as a phase function,/>Is a sine amplitude regulation parameter,/>Is the amplitude angle regulation parameter of the arctangent function,/>、/>Is a regulating and controlling parameter of the performance proportion between focal planes for a phase function,/>A period that is the phase function; the first zone diffraction profile gave the design result po=0.900, so=0.800, co=0.450, and the second zone diffraction profile gave the design result po=0.900, so=0, co=0.450, with the demarcation point of the two zones p 1 =0.65 mm.
2. The intraocular lens of claim 1 wherein the first and second optical surfaces are both even aspheres with a profile height of the even aspheresThe following formula is satisfied:
，
Wherein c is the inverse of the radius of curvature of the even aspheric surface, k is the conic coefficient of the even aspheric surface, r is the radial distance from the optical axis to a point on the surface, Is aspheric high order term coefficient,/>To normalize the radial coordinates.
3. The intraocular lens with a combined smooth diffractive profile according to claim 1, wherein the base lens has an edge thickness of 0.2mm-0.3mm and a center thickness of 0.7mm-1.2mm; the diameter of the diffraction profile optical zone, i.e. the zone of the surface of the lens body where the diffraction profile is provided, is 6mm.
4. The intraocular lens with a combined smooth diffractive profile according to claim 2, wherein the total surface profile height of the second optical surfaceThe following formula is satisfied:
，
wherein, The profile height is even aspheric; /(I)Is the height of the diffraction profile; r is the radial distance of the optical axis to a point on the plane.
5. The intraocular lens with a combined smooth diffractive profile according to claim 4,
，
Wherein lambda is the design wavelength,Refractive index of intraocular lens,/>For the refractive index of the medium surrounding the intraocular lens,Is the phase function corresponding to the diffraction profile.
6. The intraocular lens of claim 1,4 or 5, wherein the lens body satisfies one or more of the following conditions: (a) The lens body is prepared from hydrophobic acrylic ester, hydrophilic acrylic ester or polymethyl methacrylate; (b) the wavelength of the lens body is 555nm.
7. The intraocular lens of claim 1, 4 or 5 having a combined smooth diffraction profile, wherein the intraocular lens base power ranges from +10d to +30d.
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| CN110022797A (en) * | 2016-11-16 | 2019-07-16 | 塔特维姆有限责任公司 | Intraocular lens with extended focal depth |
| CN111065959A (en) * | 2017-07-26 | 2020-04-24 | Vsy生物技术和医药公司 | Multifocal diffractive lenses for ophthalmic use |
| CN114781187A (en) * | 2022-05-31 | 2022-07-22 | 南开大学 | Optimization method for smooth phase multifocal intraocular lens design |
| CN115024859A (en) * | 2022-05-31 | 2022-09-09 | 南开大学 | Multifocal intraocular lens with smooth phase distribution |
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| US11106056B2 (en) * | 2019-03-28 | 2021-08-31 | Aizhong Zhang | Subzonal multifocal diffractive lens |
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|---|---|---|---|---|
| CN110022797A (en) * | 2016-11-16 | 2019-07-16 | 塔特维姆有限责任公司 | Intraocular lens with extended focal depth |
| CN111065959A (en) * | 2017-07-26 | 2020-04-24 | Vsy生物技术和医药公司 | Multifocal diffractive lenses for ophthalmic use |
| CN114781187A (en) * | 2022-05-31 | 2022-07-22 | 南开大学 | Optimization method for smooth phase multifocal intraocular lens design |
| CN115024859A (en) * | 2022-05-31 | 2022-09-09 | 南开大学 | Multifocal intraocular lens with smooth phase distribution |
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| Title |
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| 适用于大范围角膜非球面系数的双区域非球面衍射型人工晶体;谷健达 等;光学学报;第40卷(第10期);2, 4, 7, 8 * |
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