CN116250888A

CN116250888A - Intratumoral embolism implant

Info

Publication number: CN116250888A
Application number: CN202310544899.2A
Authority: CN
Inventors: 李彬彬; 吕纬岩; 孙剑
Original assignee: Beijing Jiushi Shenkang Medical Technology Co ltd
Current assignee: Beijing Jiushi Shenkang Medical Technology Co ltd
Priority date: 2023-05-16
Filing date: 2023-05-16
Publication date: 2023-06-13

Abstract

The invention relates to an intratumoral embolic implant, which comprises a plurality of braided wires braided into a net; the mesh is a columnar structure with the cross-sectional area being variable along with the longitudinal expansion and contraction of the mesh, and comprises a proximal end part, a distal end part and a cavity, wherein the number of the braided wires of the proximal end part is larger than that of the braided wires of the distal end part. The intratumoral embolic implant provided by the invention is used for treating aneurysms, increases the selectivity of an operation scheme, enhances the adaptability to the shape of the aneurysms, improves the effective area of the implant, and reduces the operation failure rate.

Description

Intratumoral embolism implant

Technical Field

The invention relates to the field of medical instruments, in particular to an intratumoral embolism implant.

Background

Aneurysms are a common vascular disease that is caused by lesions or lesions in the arterial wall, forming localized or diffuse distensions or distensions of the arterial wall, with the swelling, pulsating mass being the main manifestation. Aneurysms can occur anywhere in the arterial system. Once the aneurysm breaks, serious consequences, such as rupture of intracranial aneurysm, subarachnoid hemorrhage, and serious cases can cause vascular spasm to cause wide cerebral infarction, thereby causing hemiplegia, coma and the like, can be caused. The open surgical treatment scheme for aneurysms requires opening the body cavity surrounding the aneurysm, such as craniotomy, thoracotomy, etc., causing great damage to the patient's body and long post-operative recovery period. Thus, various alternative and less invasive procedures are used to treat aneurysms, which are currently the preferred clinical treatment options for many medical professionals, with the advantage of their minimally invasive, safe, and effective endovascular intervention.

At present, the device for the intraarterial embolism mainly comprises a total embolic device of the aneurysm sac and a plugging device for the neck of the aneurysm. It has the following drawbacks: the occluding device for the tumor neck is simpler in instrument selection, but the displacement that may occur is relatively greater. The main problem of the total embolism device of the tumor sac is that the device has poor compliance to the tumor body, and meanwhile, after the device is released on the sac, if the product does not completely correspond to the neck of the tumor, the device can not only play a role in treatment, but also easily cause rupture and bleeding of the aneurysm in the later stage, so that the device has more difficult treatment on the aneurysm on the side wall.

Disclosure of Invention

The invention aims to solve the technical problems of single treatment surface and poor compliance, and provides an intratumoral embolism implant for solving the problems of single treatment surface and poor compliance.

The invention is realized by the following technical scheme:

an intratumoral embolic implant, the implant comprising a plurality of braided filaments braided into a mesh; the mesh is a columnar structure with the cross-sectional area being variable along with the longitudinal expansion and contraction of the mesh, and comprises a proximal end part, a distal end part and a cavity, wherein the number of the braided wires of the proximal end part is larger than that of the braided wires of the distal end part.

Further, in the intratumoral embolic implant, the proximal ends of the braided wires of the proximal end portion are gathered and sealed, the distal ends of the braided wires of the distal end portion are gathered and sealed, and the distal ends of a part of the braided wires of the proximal end portion are integrally connected with the proximal ends of all the braided wires of the distal end portion in a one-to-one correspondence manner.

Further, in the intratumoral embolic implant, the distal end of the other part of the braided wire of the proximal end portion is a free end.

Further, the distal ends of the other part of the braided wires of the proximal end part are connected into a whole in pairs.

Further, in the intratumoral embolic implant, the distal ends of the other part of the braided wires of the proximal end part are connected into a whole two by two after extending to the distal end of the distal end part.

Further, in the intratumoral embolic implant, the mesh density of the proximal section is greater than the mesh density of the distal section.

Further, in the intratumoral embolic implant, the diameter of the integrally connected braided wire of the proximal end portion and the distal end portion is 0.015mm to 0.1mm.

Further, in the intratumoral embolic implant, the diameter of the braided wire of the other part of the proximal end part is 0.015-0.2mm.

Further, the diameter of the proximal portion is greater than or equal to the diameter of the distal portion.

Further, the length ratio of the proximal end portion to the distal end portion in the axial direction of the intratumoral embolic implant is 9 or less.

The invention has the advantages and effects that:

1. the intratumoral embolic implant provided by the invention is used for treating aneurysms, increases the selectivity of an operation scheme, enhances the adaptability to the shape of the aneurysms, improves the effective area of the implant, and reduces the operation failure rate.

2. The number of the braided wires of the proximal end part of the intratumoral embolic implant provided by the invention is larger than that of the braided wires of the distal end part, and the intratumoral embolic implant has a certain metal coverage rate at the plugging port, so that blood is prevented from flowing into an aneurysm, and the deformability is improved on the premise of ensuring the stability.

Drawings

FIG. 1 shows a schematic structural view of an intratumoral embolic implant according to example 1 provided by the present invention;

FIG. 2 shows a schematic application of the intratumoral embolic implant of example 1 provided by the present invention;

FIG. 3 shows a schematic structural view of an intratumoral embolic implant according to example 2 provided by the present invention;

fig. 4 shows a schematic structural view of an intratumoral embolic implant according to example 3 provided by the present invention.

Reference numerals illustrate: 1-braided wire, 2-proximal portion, 3-distal portion, 4-radiopaque marker, a-proximal, B-distal.

Detailed Description

In order to make the purposes, technical solutions and advantages of the implementation of the present invention more clear, the technical solutions in the embodiments of the present invention are described in more detail below with reference to the accompanying drawings in the embodiments of the present invention. The described embodiments are some, but not all, embodiments of the invention. The embodiments described below by referring to the drawings are illustrative and intended to explain the present invention and should not be construed as limiting the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention. Embodiments of the present invention will be described in detail below with reference to the attached drawings:

in the description of the present invention, it is to be understood that, unless otherwise indicated, the meaning of "a plurality" is two or more; the terms "center," "longitudinal," "transverse," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used for convenience in describing and simplifying the description based on the orientation or positional relationship shown in the drawings, and do not denote or imply that the devices or elements being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the scope of the invention. Furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In the description of the present invention, it should also be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the above terms in the present invention can be understood as appropriate by those of ordinary skill in the art.

In this specification, the term "proximal" generally refers to an end that is proximal to the operator of the medical device, and "distal" generally refers to an end that is distal from the operator of the medical device, typically the end that enters the human body first.

Fig. 1 shows a schematic structure of an intratumoral embolic implant according to example 1 provided by the present invention, which comprises a plurality of braided filaments 1 braided into a mesh. The net is a columnar structure with the cross-sectional area changeable along with the longitudinal expansion and contraction of the net. Specifically, the delivery direction of the net in the tumor is longitudinal, and the net is radial in a state perpendicular to the longitudinal direction. The mesh has a radially constrained elongated state delivered intratumorally and a radially expanded shortened state retained intratumorally relative to the radially constrained elongated state (see fig. 2). That is, the web radially shrinks while extending in the machine direction and radially expands while reducing in the machine direction. The mesh comprises a proximal portion 2, a distal portion 3 and a cavity, the number of filaments of the proximal portion 2 being greater than the number of filaments of the distal portion 3. The proximal ends of the braided wires of the proximal end portion 2 (the ends of the braided wires indicating the position of the proximal end portion near the proximal end A) are gathered and closed, the distal ends of the braided wires of the distal end portion 3 (the ends of the braided wires indicating the position of the distal end portion near the distal end B) are gathered and closed, and at least one of the gathered positions of the two ends is provided with a radiopaque marker 4 for facilitating a doctor to accurately send the implant to a designated position under X-rays or clearly identify the position to perform corresponding operations. The braided filaments of the proximal portion 2 are divided into a portion and another portion, wherein one portion is the same as the number of braided filaments of the distal portion 3 and the remainder is the other portion. The distal ends of a part of the braided wires of the proximal end portion 2 (the ends of a part of the braided wires referring to the position of the proximal end portion near the distal end B) are integrally connected to the proximal ends of all the braided wires of the distal end portion 3 (the ends of the braided wires referring to the position of the distal end portion near the proximal end a) in one-to-one correspondence. The connection here may be integrally formed. The distal end of the other part of the braided wire of the proximal portion 2 (the end of the other part of the braided wire referring to the position of the proximal portion near the distal end B) is the free end. In particular, the braided filaments of one portion and the other portion of the proximal portion 2 are uniformly staggered.

Further, the mesh density of the proximal portion 2 is greater than the mesh density of the distal portion 3. The diameter of the integrally connected braid wires of the proximal end portion 2 and the distal end portion 3 (a part of the braid wires of the proximal end portion 2) is 0.015mm to 0.1mm, and the diameter of the other part of the braid wires of the proximal end portion 2 is 0.015mm to 0.2mm. The diameter of the proximal end portion 2 is equal to or larger than the diameter of the distal end portion 3, and the length ratio of the proximal end portion 2 to the distal end portion 3 in the axial direction is equal to or smaller than 9. The average surface coverage of the proximal sealed end (proximal end a) of the proximal portion 2 is 30% -80%, and the average surface coverage of the distal sealed end (distal end B) of the distal portion 3 is equal to or less than the average surface coverage of the proximal sealed end. The number of the knitting wires of the proximal portion 2 is 48-280 and the number of the knitting wires of the distal portion 3 is 4-216. The plane inclination angle of the proximal seal end (proximal end a) of the proximal portion 2 is 45 ° or less.

Fig. 3 is a schematic view showing the structure of an intratumoral embolic implant according to embodiment 2 of the present invention, and unlike embodiment 1, the distal ends of the other braided wires of the proximal portion 2 (the ends of the other braided wires indicating the position of the proximal portion near the distal end B) are integrally connected in pairs, so that the ends of the braided wires are more stable.

Fig. 4 is a schematic structural view of an intratumoral embolic implant according to embodiment 3 of the present invention, and unlike embodiment 1, the distal ends of the other braided wires of the proximal portion 2 (the ends of the other braided wires indicating the position of the proximal portion near the distal end B) are integrally connected two by two after extending to the distal end of the distal portion 3 (the ends indicating the vicinity of the distal end B), so that the ends of the braided wires are more stable and the supporting property is enhanced.

The above embodiments are only for illustrating the technical solution of the present invention, and are not intended to limit the implementation scope of the present invention. All equivalent changes and modifications within the scope of the present invention should be considered as falling within the scope of the present invention.

Claims

1. An intratumoral embolic implant, comprising a plurality of braided filaments braided into a mesh; the mesh is a columnar structure with the cross-sectional area being variable along with the longitudinal expansion and contraction of the mesh, and comprises a proximal end part, a distal end part and a cavity, wherein the number of the braided wires of the proximal end part is larger than that of the braided wires of the distal end part.

2. The intratumoral embolic implant according to claim 1, wherein the proximal ends of the braided wires of the proximal portion are gathered and closed, the distal ends of the braided wires of the distal portion are gathered and closed, and the distal ends of a portion of the braided wires of the proximal portion are integrally connected to the proximal ends of all the braided wires of the distal portion in a one-to-one correspondence.

3. An intratumoral embolic implant according to claim 2, wherein the distal end of the other portion of the braided filaments of the proximal portion is a free end.

4. An intratumoral embolic implant according to claim 2, wherein the distal ends of the other partial braided filaments of said proximal portion are integrally joined one by one.

5. An intratumoral embolic implant according to claim 2, wherein the distal ends of the other partial braided filaments of said proximal section are integrally joined one to the other after the distal ends of said distal section.

6. An intratumoral embolic implant according to any of claims 1-5, wherein said proximal portion has a mesh density greater than that of said distal portion.

7. An intratumoral embolic implant according to any of claims 2-5, wherein the diameter of the integrally connected braided filaments of said proximal and distal portions is 0.015mm-0.1mm.

8. An intratumoral embolic implant according to any of claims 2 to 5, wherein the diameter of the other part of the braided filaments of said proximal section is 0.015-0.2mm.

9. An intratumoral embolic implant according to any of claims 1-5, wherein the diameter of said proximal portion is greater than or equal to the diameter of said distal portion.

10. An intratumoral embolic implant according to any of claims 1-5, wherein the ratio of the length of said proximal portion to the length of said distal portion in the axial direction is 9 or less.