CN116222158A - Method and device for controlling freeze dryer, freeze dryer and storage medium - Google Patents
Method and device for controlling freeze dryer, freeze dryer and storage medium Download PDFInfo
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- CN116222158A CN116222158A CN202310207507.3A CN202310207507A CN116222158A CN 116222158 A CN116222158 A CN 116222158A CN 202310207507 A CN202310207507 A CN 202310207507A CN 116222158 A CN116222158 A CN 116222158A
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
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Abstract
The application relates to the technical field of freeze drying, and discloses a method for controlling a freeze dryer, wherein the freeze dryer comprises a drying chamber, a vacuum pump, a heating device and a weighing device, a freeze-drying object is freeze-dried in the drying chamber, the vacuum pump is used for vacuumizing the drying chamber, the weighing device is used for acquiring the weight of the freeze-drying object, and the heating device acts on the freeze-drying object; the method comprises the following steps: acquiring the weight of the freeze-dried object for multiple times; calculating a weight change parameter of the freeze-dried object; and controlling the operation of the heating device according to the weight change parameter. By using the method for controlling the freeze dryer disclosed by the application, a good freeze-drying effect can be achieved on a freeze-drying object under the condition that the physicochemical property of the freeze-drying object is not clear. The application also discloses a device for controlling the freeze dryer, the freeze dryer and a storage medium.
Description
Technical Field
The present application relates to the field of freeze drying technology, for example, to a method and apparatus for controlling a freeze dryer, and a storage medium.
Background
The freeze dryer sublimates solid water in the freeze-dried object by creating a vacuum low-temperature environment, thereby realizing dehydration and drying of the freeze-dried object. The freeze-dried object needs to maintain a certain shape and internal structure by low temperature, and the temperature thereof is low, so that it is difficult to provide sufficient sublimation latent heat for sublimation of the solid water. This affects the lyophilization effect of the lyophilized object, increasing the time required for lyophilization.
In order to accelerate the freeze-drying process, a microwave vacuum freeze-drying device and a microwave vacuum freeze-drying method thereof are disclosed in the related art, and in the early drying stage, electric heating is used as a main mode for providing sublimation latent heat so as to promote mass sublimation of material moisture; sublimation is hindered in the later stage of drying, and the latent heat of sublimation is provided by microwave heating. The method determines real-time moisture content according to the initial moisture content and weight change of the material, and switches electric heating and microwave heating according to the real-time moisture content. And in the microwave heating stage, heating of microwaves is regulated according to a preset program according to the freeze-drying characteristics of the materials.
In the process of implementing the embodiments of the present disclosure, it is found that at least the following problems exist in the related art:
the method controls the heating device based on the initial moisture content and the freeze-drying characteristic of the material, and a good freeze-drying effect is difficult to obtain under the condition that the physicochemical properties of the material are unknown or have deviation.
It should be noted that the information disclosed in the foregoing background section is only for enhancing understanding of the background of the present application and thus may include information that does not form the prior art that is already known to those of ordinary skill in the art.
Disclosure of Invention
The following presents a simplified summary in order to provide a basic understanding of some aspects of the disclosed embodiments. This summary is not an extensive overview, and is intended to neither identify key/critical elements nor delineate the scope of such embodiments, but is intended as a prelude to the more detailed description that follows.
The embodiment of the disclosure provides a method and a device for controlling a freeze dryer, the freeze dryer and a storage medium, so as to achieve a good freeze-drying effect on a freeze-drying object under the condition that the physicochemical property of the freeze-drying object is not clear.
In some embodiments, the freeze dryer comprises a drying chamber in which a freeze-dried object is freeze-dried, a vacuum pump for evacuating the drying chamber, a heating device for acquiring the weight of the freeze-dried object, and a weighing device for acting on the freeze-dried object; the method comprises the following steps: acquiring the weight of the freeze-dried object for multiple times; calculating a weight change parameter of the freeze-dried object; and controlling the operation of the heating device according to the weight change parameter.
In some embodiments, said controlling operation of the heating device according to said weight variation parameter comprises: starting the heating device and determining the heating value of the heating device according to the weight change parameter under the condition that the weight change parameter is greater than or equal to a weight change threshold; or, turning off the heating device and turning off the vacuum pump if the weight change parameter is less than a weight change threshold.
In some embodiments, after the determining the heating value of the heating device according to the weight change parameter, the method further includes: acquiring the temperature of a freeze-dried object; and turning off the heating device when the temperature of the freeze-drying object is greater than a temperature threshold.
In some embodiments, after the determining the heating value of the heating device according to the weight change parameter, the method further includes: acquiring the temperature of a freeze-dried object for multiple times; the heating value of the heating device is adjusted according to the temperature of the freeze-drying object.
In some embodiments, the adjusting the heating value of the heating device according to the change in the temperature of the lyophilization object comprises: reducing the heating value of the heating device when the temperature of the freeze-drying object increases; or, when the temperature of the freeze-dried object is reduced, the heating amount of the heating device is increased.
In some embodiments, the multiple acquiring weights of the lyophilization object comprises: starting the vacuum pump to vacuumize the drying chamber; and under the condition that the vacuum pump is started for a preset time period, periodically acquiring the weight of the freeze-drying object.
In some embodiments, the calculating the weight change parameter of the lyophilization object comprises: k=m 1 -m 2 Wherein k is the weight variation parameter, m 1 For the weight of the freeze-dried object obtained last time, m 2 The weight of the freeze-dried object obtained this time is used.
In some embodiments, the apparatus for controlling a freeze dryer comprises a processor and a memory storing program instructions, the processor being configured to perform the above-described method for controlling a freeze dryer when running the program instructions.
In some embodiments, the freeze dryer comprises a freeze dryer body, a vacuum pump, a heating device, a weighing device and the device for controlling the freeze dryer, wherein the freeze dryer body defines a drying chamber inside the freeze dryer body, and the drying chamber is used for placing a freeze-drying object; the vacuum pump is connected with the drying chamber and is used for vacuumizing the drying chamber; the heating device is arranged on the freeze dryer body and used for providing sublimation heat for solid water in a freeze-drying object; the weighing device is arranged on the freeze dryer body and used for acquiring the weight of a freeze-drying object; a device for controlling a freeze dryer is mounted to the dryer body.
In some embodiments, the storage medium stores program instructions that, when executed, perform the above-described method for controlling a freeze dryer.
The method and the device for controlling the freeze dryer, the freeze dryer and the storage medium provided by the embodiment of the disclosure can realize the following technical effects:
1. the weight change parameter according to which the heating device is controlled is obtained according to the weight of the freeze-drying object, the freeze dryer does not need to predict the initial water content of the freeze-drying object or pre-load the freeze-drying program matched with the freeze-drying object, and the application range of the freeze dryer is wider;
2. and determining the weight change parameter of the freeze-drying object according to the weight of the freeze-drying object obtained for multiple times, wherein the weight change parameter of the freeze-drying object is objective and accurate, and the freeze dryer is more accurate in control of the heating device.
The foregoing general description and the following description are exemplary and explanatory only and are not restrictive of the application.
Drawings
One or more embodiments are illustrated by way of example and not limitation in the figures of the accompanying drawings, in which like references indicate similar elements, and in which like reference numerals refer to similar elements, and in which:
FIG. 1 is a schematic diagram of a freeze dryer according to an embodiment of the present disclosure;
FIG. 2 is a schematic diagram of a method for controlling a freeze dryer provided in an embodiment of the present disclosure;
FIG. 3 is a schematic illustration of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;
FIG. 4 is a schematic diagram of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;
FIG. 5 is a schematic diagram of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;
FIG. 6 is a schematic diagram of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;
FIG. 7 is a schematic diagram of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;
FIG. 8 is a schematic diagram of an apparatus for controlling a freeze dryer provided in an embodiment of the present disclosure;
fig. 9 is a schematic structural view of another freeze dryer provided in an embodiment of the present disclosure.
Detailed Description
So that the manner in which the features and techniques of the disclosed embodiments can be understood in more detail, a more particular description of the embodiments of the disclosure, briefly summarized below, may be had by reference to the appended drawings, which are not intended to be limiting of the embodiments of the disclosure. In the following description of the technology, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the disclosed embodiments. However, one or more embodiments may still be practiced without these details. In other instances, well-known structures and devices may be shown simplified in order to simplify the drawing.
The terms first, second and the like in the description and in the claims of the embodiments of the disclosure and in the above-described figures are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate in order to describe embodiments of the present disclosure. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion.
The term "plurality" means two or more, unless otherwise indicated.
In the embodiment of the present disclosure, the character "/" indicates that the front and rear objects are an or relationship. For example, A/B represents: a or B.
The term "and/or" is an associative relationship that describes an object, meaning that there may be three relationships. For example, a and/or B, represent: a or B, or, A and B.
The term "corresponding" may refer to an association or binding relationship, and the correspondence between a and B refers to an association or binding relationship between a and B.
The freeze dryer sublimates solid water in the freeze-dried object by creating a vacuum low-temperature environment, thereby realizing dehydration and drying of the freeze-dried object. The freeze-dried object needs to maintain a certain shape and internal structure by low temperature, and the temperature thereof is low, so that it is difficult to provide sufficient sublimation latent heat for sublimation of the solid water. This affects the lyophilization effect of the lyophilized object, increasing the time required for lyophilization.
In order to accelerate the freeze-drying process, a microwave vacuum freeze-drying device and a microwave vacuum freeze-drying method thereof are disclosed in the related art, and in the early drying stage, electric heating is used as a main mode for providing sublimation latent heat so as to promote mass sublimation of material moisture; sublimation is hindered in the later stage of drying, and the latent heat of sublimation is provided by microwave heating. The method determines real-time moisture content according to the initial moisture content and weight change of the material, and switches electric heating and microwave heating according to the real-time moisture content. And in the microwave heating stage, heating of microwaves is regulated according to a preset program according to the freeze-drying characteristics of the materials. The related art has a problem in that the method controls the heating device based on the initial moisture content and the freeze-drying property of the material, and it is difficult to obtain a good freeze-drying effect in the case that the physicochemical properties of the material are unknown or have deviation.
According to the method for controlling the freeze dryer, the operation of the heating device is controlled according to the weight change parameters, and good freeze drying effect can be obtained under the condition that the physical and chemical properties of the initial water content and the like of the freeze-drying object are unknown.
As shown in conjunction with fig. 1, an embodiment of the present disclosure provides a freeze dryer including a drying chamber 201, a vacuum pump 202, a heating device 203, and a weighing device 204, a freeze-dried object is freeze-dried in the drying chamber 201, the vacuum pump 202 is used to vacuumize the drying chamber 201, the weighing device 204 is used to obtain the weight of the freeze-dried object, and the heating device 203 acts on the freeze-dried object.
The drying chamber is used for providing a drying environment for the freeze-dried object, and is a chamber with density. The vacuum pump is connected to the drying chamber, and the vacuum pump is used for vacuumizing the drying chamber during operation. The boiling point of the solid water in the freeze-dried object is reduced under the environment of low air pressure, and the solid water is easy to sublimate into gaseous water. The gaseous water sublimates to absorb heat, and the heating device is used for supplementing heat for the freeze-drying object. The weighing device is used for acquiring the weight of the freeze-dried object, and is illustratively a weight sensor arranged in the drying chamber.
By using the freeze dryer provided by the embodiment of the disclosure, sublimation heat is supplemented to the freeze-drying object through the heating device, so that the freeze-drying process of the freeze-drying object can be accelerated; the weight of the freeze-drying object is obtained through the weighing device, so that the freeze-drying state of the freeze-drying object can be judged, and the freeze dryer is favorable for accurate freeze-drying control.
Referring to fig. 2, an embodiment of the disclosure provides a method for controlling a freeze dryer, which is applied to the freeze dryer, and includes:
s01, the weighing device acquires the weight of the freeze-dried object for multiple times.
S02, calculating the weight change parameter of the freeze-drying object by the freeze dryer.
S03, controlling the operation of the heating device according to the weight change parameter freeze dryer.
The drying stage of lyophilization is generally divided into a sublimation drying stage and a resolution drying stage. The sublimation drying stage is also called primary drying, and sublimation of the water in solid state is gradually shifted inward from the outer surface of the object to be freeze-dried. The void left after the sublimation of the solid water serves as an escape channel for the subsequent sublimation of the solid water.
In the sublimation drying stage, the sublimation rate of the water in solid state is different. At the initial stage of freeze-drying, the sublimation speed of solid water is higher. As lyophilization proceeds, the sublimation rate of the solid water decreases, approaching zero at the end of lyophilization.
The sublimation of solid water can absorb certain heat, and the heat that freeze-drying object self stored is limited, and the sublimation of solid water is influenced when solid water is difficult to absorb heat from the freeze-drying object.
The sublimation heat is provided for the solid water through the heating device, so that the sublimation of the solid water can be accelerated, and the time required for freeze-drying is reduced. However, after the heating device is turned on, the structure of the freeze-dried object may be melted or collapsed, and the freeze-drying effect may be affected.
Based on this, the control method for controlling the freeze dryer provided by the embodiment of the disclosure controls the operation of the heating device according to the heat required for sublimation of the freeze-drying object from the perspective of the heat required for sublimation of the solid water. Specifically, the freeze-drying object is supplemented with sublimation heat adapted to the sublimation rate according to the sublimation rate of the solid water. The heating device is started to enable the freeze-dried object to be in a heat balance state, and the expected freeze-drying effect of the freeze-dried object is achieved while the freeze-drying process is accelerated.
The sublimation rate of solid water is not easily measured, but as the solid water sublimates, the weight of the lyophilized object also changes. Therefore, the weight change parameter of the freeze-dried object is regarded as a synchronization index of the solid water sublimation rate. Illustratively, within a preset period of time, the solid water sublimation rate is considered to be faster if the weight change of the lyophilization object is large, and the solid water sublimation rate is considered to be slower if the weight change of the lyophilization object is small.
The operation of the heating device is controlled according to the weight change parameters, and the operation of the heating device can correspond to the sublimation speed of the solid water in the freeze-drying object, so that the freeze-drying effect is improved, and the time required by freeze-drying is shortened.
The weight change parameter of the freeze-dried object is calculated by the weight of the freeze-dried object obtained a plurality of times. The physical and chemical properties such as the initial weight and the initial water content of the lyophilized object are not known in advance. After the freeze-drying object is placed in the drying chamber, the freeze dryer can acquire the weight of the freeze-drying object for a plurality of times, calculate the weight change parameter of the freeze-drying object, and control the operation of the heating device according to the weight change parameter.
Different from the method in the related art, the type of the material which can be freeze-dried by the method in the related art is limited by the type of the material which can be freeze-dried by the built-in program, and the method provided by the embodiment of the disclosure can have a good freeze-drying effect on any unknown type of freeze-dried object; in the method in the related art, under the condition that the physical and chemical parameters such as the initial water content of the material, the freeze-drying object and the like are unknown or the fluctuation of different batches of materials is large, certain deviation can appear in control, and the technical scheme of the application relies on the real-time weight of the current freeze-drying object, so that the control is more stable.
By using the method for controlling the freeze dryer provided by the embodiment of the disclosure, the weight change parameter according to which the heating device is controlled is obtained according to the weight of the freeze-dried object, the freeze dryer does not need to predict the initial water content of the freeze-dried object or pre-load the freeze-drying program matched with the freeze-dried object, and the application range of the freeze dryer is wider; and determining the weight change parameter of the freeze-drying object according to the weight of the freeze-drying object obtained for multiple times, wherein the weight change parameter of the freeze-drying object is objective and accurate, and the freeze dryer is more accurate in control of the heating device.
In the related art, a freeze dryer uses a temperature of a freeze-dried object as a main control means in a freeze-drying process, for example, controls the freeze-dried object to be kept at a preset temperature for a preset time period, and controls an operation of a heating device according to a temperature change of the freeze-dried object, so that the freeze-dried object is kept at the preset temperature.
The control method has the problems that the preset temperature is needed to be preset at first, and the application range of the freeze dryer is limited; and the sublimation speed of the solid water in the freeze-drying object is limited by the preset temperature, and the freeze-drying effect is poor under the condition that the temperature is set unreasonably or has deviation.
The method for controlling the freeze dryer provided by the embodiment of the disclosure controls the operation of the heating device through the weight change parameter of the freeze-drying object, so that the heat supplemented by the heating device is dynamically balanced with the heat required by sublimation of the solid water, and the temperature of the freeze-drying object is allowed to have certain fluctuation. This eliminates the need to predict the preset temperature to achieve a good lyophilization effect on the lyophilizer and shortens the time required for lyophilization.
As shown in connection with fig. 3, an embodiment of the present disclosure provides another method for controlling a freeze dryer, comprising:
s01, the weighing device acquires the weight of the freeze-dried object for multiple times.
S02, calculating the weight change parameter of the freeze-drying object by the freeze dryer.
S31, starting the heating device by the freeze dryer under the condition that the weight change parameter is greater than or equal to the weight change threshold value, and determining the heating value of the heating device according to the weight change parameter.
In the disclosed embodiments, the weight change parameter is used as a status parameter for the lyophilization process. In the case where the weight change parameter is greater than or equal to the weight change threshold, it is considered that the solid water in the freeze-dried object is still continuously sublimating. At this time, the heating device is started to supply heat for sublimation of the solid water, so that the freeze-drying process is accelerated. Further, the weight change parameter also characterizes the speed of sublimation of the water in solid state. Therefore, the heating value of the heating device is determined according to the weight change parameter. Therefore, the freeze-drying object is in a relative heat balance state in the freeze-drying process, and the expected freeze-drying effect is achieved while the freeze-drying process is accelerated. Illustratively, the weight change threshold is between 0.1 and 1% of the first measured weight of the lyophilization object. Such a weight change threshold can better reflect the freeze-dried state of the freeze-dried object.
Optionally, in step S31, in the case where the weight change parameter is greater than or equal to the weight change threshold, the freeze dryer activates the heating device and determines the heating value of the heating device according to the weight change parameter, the heating value of the heating device is determined by the following relation:
Q＝a*k
where Q is the heating value of the heating device, a is the adjustment coefficient, and k is the weight change parameter.
When the weight change of the freeze-drying object is relatively large, the sublimation speed of the solid water is relatively high, and the heating value of the heating device is relatively large; when the weight change of the freeze-dried object is small, the sublimation speed of the solid water is low, and the heating amount of the heating device is small. Thus, the freeze-drying object can be in a temperature balance state, so that the freeze-drying process is accelerated and the expected freeze-drying effect is obtained.
Alternatively, the value of the adjustment coefficient a is positively correlated with the latent heat required for sublimation of the solid water per unit weight, and negatively correlated with the absorption rate of heat by the lyophilization object. Thus, the heat supplement of the freeze dryer to the freeze-drying object can be more accurate.
Optionally, the freeze dryer starts the heating device and determines the heating value of the heating device according to the weight change parameter if the weight change parameter is greater than or equal to the weight change threshold in step S31 includes: determining target power of the heating device according to the heating value of the heating device; the output power of the heating device is gradually increased to the target power.
In the case of a relatively high vacuum, the lyophilized object receives heat mainly by heat radiation and heat transfer. Inside the freeze-dried object, the interface where sublimation occurs gradually moves from outside to inside. After the power of the heating device is increased, heat is not transferred to the inside of the freeze-dried object, and the surface temperature of the freeze-dried object is possibly too high, so that collapse or melting occurs. The power of the heating device is gradually increased, and a certain time is provided for the conduction of heat in the freeze-drying object. Compared with the mode of directly improving the output power of the heating device to the target power, the method reduces the risk of fusion collapse of the surface of the freeze-drying object and improves the freeze-drying effect of the freeze-drying object.
As shown in connection with fig. 4, an embodiment of the present disclosure provides another method for controlling a freeze dryer, comprising:
s01, the weighing device acquires the weight of the freeze-dried object for multiple times.
S02, calculating a weight change parameter of a freeze-drying object by the freeze dryer;
s31, starting the heating device by the freeze dryer under the condition that the weight change parameter is greater than or equal to the weight change threshold value, and determining the heating value of the heating device according to the weight change parameter.
S32, switching off the heating device and switching off the vacuum pump when the weight change parameter is smaller than the weight change threshold value.
The weight change parameter is used as a status parameter of the lyophilization process. In the case where the weight change parameter is smaller than the weight change threshold, it is considered that the sublimation of the solid water in the freeze-dried object is slower or no longer sublimated. At this time, there may be two cases, the first case is that the heat required for sublimation of the solid water in the freeze-drying object is insufficient and the sublimation is hindered, and the second case is that the sublimation drying is ended after the sublimation of the solid water in the freeze-drying object is completed. In the first case, the heat supplied by the heating device is matched with the heat required for sublimating the solid water, and a part of the heat accumulated by the freezing object can sublimate the solid water. Thus, the first case is excluded. Therefore, in the case where the weight change parameter is smaller than the weight change threshold, it is considered that the freeze-dried object has achieved the intended freeze-drying effect, at which time the heating device is turned off and the vacuum pump is turned off. In the embodiment of the disclosure, the weight change parameter smaller than the weight change threshold is used as the judging condition for the freeze-drying end, and the judging on the freeze-drying end is more accurate.
As shown in connection with fig. 5, an embodiment of the present disclosure provides another method for controlling a freeze dryer, comprising:
s01, the weighing device acquires the weight of the freeze-dried object for multiple times.
S02, calculating a weight change parameter of a freeze-drying object by the freeze dryer;
s31, starting the heating device by the freeze dryer under the condition that the weight change parameter is greater than or equal to the weight change threshold value, and determining the heating value of the heating device according to the weight change parameter.
S41, acquiring the temperature of a freeze-drying object by a freeze dryer;
s42, the freeze dryer turns off the heating device when the temperature of the freeze drying object is greater than the temperature threshold.
Without the heating device being activated, the temperature of the lyophilization object does not change much. After the heating device is started, there is a possibility that the temperature of the freeze-dried object increases. And in the case where the temperature of the freeze-dried object is greater than the temperature threshold, the freeze-dried object is considered to be at risk of fusion collapse. At this time, the heating device is turned off to set the temperature of the freeze-drying object within a preset interval.
The temperature of the freeze-drying object is obtained after the heating device is started, so that the operation amount of the freeze dryer can be reduced. The heating device is turned off when the temperature of the freeze-drying object is greater than the temperature threshold, so that the freeze-drying object can be prevented from being excessively high in temperature, and the expected freeze-drying effect can be obtained.
Optionally, the temperature threshold is a disintegration temperature of the lyophilized object. The disintegration temperature is used as a temperature threshold of the freeze-drying object, so that the surface of the freeze-drying object can be prevented from collapsing.
Optionally, the temperature threshold is determined according to the following relation:
T＝T0±c
where T is a temperature threshold, T0 is a temperature of the lyophilization object when the heating device is started, and c is a temperature tolerance, and illustratively, c has a value of 2. Thus, the freeze dryer can also have a good freeze-drying effect on the freeze-dried object under the condition that the disintegration temperature of the freeze-dried object is unknown.
As shown in connection with fig. 6, an embodiment of the present disclosure provides another method for controlling a freeze dryer, comprising:
s01, the weighing device acquires the weight of the freeze-dried object for multiple times.
S02, calculating the weight change parameter of the freeze-drying object by the freeze dryer.
S31, starting the heating device by the freeze dryer under the condition that the weight change parameter is greater than or equal to the weight change threshold value, and determining the heating value of the heating device according to the weight change parameter.
S51, the freeze dryer acquires the temperature of the freeze-drying object for a plurality of times.
S52, adjusting the heating value of the heating device according to the temperature change freeze dryer of the freeze drying object.
Without the heating device being activated, the temperature of the lyophilization object does not change much. After the heating device is started, there is a possibility that the temperature of the freeze-dried object increases. The temperature of the lyophilization object needs to be controlled. In case the temperature of the freeze-dried object is less than the temperature threshold, the freeze-dried object is not at risk of collapsing or melting. The more heat provided by the heating means at this time, the more sufficient sublimation of the water in solid state in the freeze-dried object. Therefore, it is necessary to control the temperature of the freeze-dried object within a range below the temperature threshold. After the heating value of the heating device is determined according to the weight change parameter, the heating value of the heating device is corrected according to the temperature change of the freeze-drying object. Therefore, the heating value of the heating device is accurately controlled, and the freeze-drying speed of the freeze-drying object is improved under the condition that the freeze-drying object is prevented from collapsing and melting.
Optionally, step S52, adjusting the heating value of the heating device according to the temperature of the freeze-drying object includes: when the temperature of the freeze-drying object increases, the heating value of the heating device is reduced; when the temperature of the freeze-dried object is reduced, the amount of heat generated by the heating device is increased.
When the temperature of the freeze-drying object increases, the heating device may be supplemented with a large amount of heat generation, which may cause the temperature of the freeze-drying object to further increase, and at this time, the amount of heat generation of the freeze-drying object is reduced. When the temperature of the object to be freeze-dried is reduced, the heating device may be supplemented with a smaller amount of heat generation, which may result in a lower temperature of the object to be freeze-dried and reduced sublimation of the solid water, and at this time, the amount of heat generation of the object to be freeze-dried is increased. This makes it possible to keep the temperature of the object to be lyophilized in a proper temperature range.
As shown in connection with fig. 7, an embodiment of the present disclosure provides another method for controlling a freeze dryer, comprising:
s11, starting a vacuum pump to vacuumize the drying chamber by the freeze dryer.
S12, under the condition that the vacuum pump is started for a preset time period, the freeze dryer periodically acquires the weight of the freeze-dried object.
S02, calculating the weight change parameter of the freeze-drying object by the freeze dryer.
S03, controlling the operation of the heating device according to the weight change parameter freeze dryer.
At the initial stage of starting the vacuum pump, the vacuum degree of the drying chamber gradually increases. In this process, the sublimation rate of the water in solid state in the freeze-dried object is gradually increased. As the vacuum level increases and the sublimation surface in the lyophilization object moves inward, the sublimation rate of the solid water gradually decreases. If the weight of the freeze-dried object is obtained too early, the freeze dryer may misjudge the freeze-drying process of the freeze-dried object. For example, in the initial stage of starting the vacuum pump, the weight of the freeze-dried object is changed little or no, and the freeze dryer is easily considered to be close to the end of freeze-drying of the freeze-dried object simply by the weight change. Therefore, the weight of the freeze-dried object is periodically acquired after the vacuum pump is started for a preset period of time. Therefore, misjudgment of the freeze dryer on the freeze drying process can be avoided, and the reliability of the freeze dryer on freeze drying control is improved.
Optionally, in calculating the weight change parameter of the freeze-dried object by the freeze dryer in step S02, the weight change parameter of the freeze dryer is calculated according to the following formula:
k＝m 1 -m 2 ，
wherein k is a weight change parameter, m 1 For the weight of the freeze-dried object obtained last time, m 2 The weight of the freeze-dried object obtained this time is used.
The weight change parameter is an amount that characterizes the rate of loss of solid water in the lyophilized object. In the case of acquiring the weight of the freeze-dried object a plurality of times, the difference between the weight acquired the previous time and the weight acquired the current time can better reflect the sublimation amount of the solid water. In the case of periodically acquiring the weight of the freeze-dried object, the difference between the previously acquired weight and the currently acquired weight may also characterize the sublimation rate of the solid water. Therefore, the difference between the weight of the freeze-dried object acquired in the previous time and the weight of the freeze-dried object acquired in the current time is used as a weight change parameter, so that the freeze dryer can control the heating device more accurately.
Optionally, in calculating the weight change parameter of the freeze-dried object by the freeze dryer in step S02, the weight change parameter of the freeze dryer is calculated according to the following formula:
k＝(m 1 -m 2 )/m 1
wherein k is a weight change parameter, m 1 For the weight of the freeze-dried object obtained last time, m 2 The weight of the freeze-dried object obtained this time is used.
By adopting the parameter form, the weight change parameter is a ratio, and the sublimation quantity and the sublimation speed of the solid water are reflected, so that the correlation calculation of the sublimation quantity and the sublimation speed of the solid water with the heating device is convenient.
Optionally, in calculating the weight change parameter of the freeze-dried object by the freeze dryer in step S02, the weight change parameter of the freeze dryer is calculated according to the following formula:
k＝(m 1 -m 2 )/t
wherein k is a weight change parameter, m 1 For the weight of the freeze-dried object obtained last time, m 2 For the weight of the freeze-dried object obtained this time, t is the time interval between the weight of the freeze-dried object measured the previous time and the weight of the freeze-dried object measured this time.
In the case where the manner of acquiring the weight of the freeze-dried object a plurality of times is non-periodic acquisition, introducing the time interval t allows the weight change parameter k to better reflect the sublimation rate of the solid water.
As shown in connection with fig. 8, an embodiment of the present disclosure provides an apparatus 10 for controlling a freeze dryer, including a processor (processor) 100 and a memory (memory) 101. Optionally, the apparatus may further comprise a communication interface (Communication Interface) 102 and a bus 103. The processor 100, the communication interface 102, and the memory 101 may communicate with each other via the bus 103. The communication interface 102 may be used for information transfer. Processor 100 may invoke logic instructions in memory 101 to perform the method for controlling a freeze dryer of the above-described embodiments.
Further, the logic instructions in the memory 101 described above may be implemented in the form of software functional units and may be stored in a computer readable storage medium when sold or used as a stand alone product.
The memory 101 is a computer readable storage medium that can be used to store a software program, a computer executable program, such as program instructions/modules corresponding to the methods in the embodiments of the present disclosure. The processor 100 executes functional applications and data processing by running program instructions/modules stored in the memory 101, i.e. implements the method for controlling a freeze dryer in the above-described embodiments.
The memory 101 may include a storage program area and a storage data area, wherein the storage program area may store an operating system, at least one application program required for a function; the storage data area may store data created according to the use of the terminal device, etc. Further, the memory 101 may include a high-speed random access memory, and may also include a nonvolatile memory.
Referring to fig. 1 and 9, an embodiment of the present disclosure provides a freeze dryer, including: a lyophilizer body 20, and the above-described apparatus 10 for controlling a lyophilizer. The apparatus 200 for controlling a freeze dryer is mounted to a freeze dryer body. The mounting relationships described herein are not limited to placement within a product, but include mounting connections to other components of a product, including but not limited to physical, electrical, or signal transmission connections, etc. Those skilled in the art will appreciate that the apparatus 10 for controlling a freeze dryer may be adapted to a viable product body, thereby achieving other viable embodiments.
Embodiments of the present disclosure provide a computer-readable storage medium storing computer-executable instructions configured to perform the above-described method for controlling a freeze dryer.
The computer readable storage medium may be a transitory computer readable storage medium or a non-transitory computer readable storage medium.
Embodiments of the present disclosure may be embodied in a software product stored on a storage medium, including one or more instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to perform all or part of the steps of a method of embodiments of the present disclosure. And the aforementioned storage medium may be a non-transitory storage medium including: a plurality of media capable of storing program codes, such as a usb (universal serial bus), a removable hard disk, a Read-only Memory (ROM), a random access Memory (RAM, randomAccess Memory), a magnetic disk, or an optical disk, or a transitory storage medium.
The above description and the drawings illustrate embodiments of the disclosure sufficiently to enable those skilled in the art to practice them. Other embodiments may involve structural, logical, electrical, process, and other changes. The embodiments represent only possible variations. Individual components and functions are optional unless explicitly required, and the sequence of operations may vary. Portions and features of some embodiments may be included in, or substituted for, those of others. Moreover, the terminology used in the present application is for the purpose of describing embodiments only and is not intended to limit the claims. As used in the description of the embodiments and the claims, the singular forms "a," "an," and "the" (the) are intended to include the plural forms as well, unless the context clearly indicates otherwise. Similarly, the term "and/or" as used in this application is meant to encompass any and all possible combinations of one or more of the associated listed. Furthermore, when used in this application, the terms "comprises," "comprising," and/or "includes," and variations thereof, mean that the stated features, integers, steps, operations, elements, and/or components are present, but that the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof is not precluded. Without further limitation, an element defined by the phrase "comprising one …" does not exclude the presence of other like elements in a process, method or apparatus comprising such elements. In this context, each embodiment may be described with emphasis on the differences from the other embodiments, and the same similar parts between the various embodiments may be referred to each other. For the methods, products, etc. disclosed in the embodiments, if they correspond to the method sections disclosed in the embodiments, the description of the method sections may be referred to for relevance.
Those of skill in the art will appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware, or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the solution. The skilled artisan may use different methods for each particular application to achieve the described functionality, but such implementation should not be considered to be beyond the scope of the embodiments of the present disclosure. It will be clearly understood by those skilled in the art that, for convenience and brevity of description, specific working procedures of the above-described systems, apparatuses and units may refer to corresponding procedures in the foregoing method embodiments, which are not repeated herein.
In the embodiments disclosed herein, the disclosed methods, articles of manufacture (including but not limited to devices, apparatuses, etc.) may be practiced in other ways. For example, the apparatus embodiments described above are merely illustrative, and for example, the division of the units may be merely a logical function division, and there may be additional divisions when actually implemented, for example, multiple units or components may be combined or integrated into another system, or some features may be omitted, or not performed. In addition, the coupling or direct coupling or communication connection shown or discussed with each other may be through some interface, device or unit indirect coupling or communication connection, which may be in electrical, mechanical or other form. The units described as separate units may or may not be physically separate, and units shown as units may or may not be physical units, may be located in one place, or may be distributed over a plurality of network units. Some or all of the units may be selected according to actual needs to implement the present embodiment. In addition, each functional unit in the embodiments of the present disclosure may be integrated in one processing unit, or each unit may exist alone physically, or two or more units may be integrated in one unit.
The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to embodiments of the present disclosure. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. In the description corresponding to the flowcharts and block diagrams in the figures, operations or steps corresponding to different blocks may also occur in different orders than that disclosed in the description, and sometimes no specific order exists between different operations or steps. For example, two consecutive operations or steps may actually be performed substantially in parallel, they may sometimes be performed in reverse order, which may be dependent on the functions involved. Each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
Claims (10)
1. A method for controlling a freeze dryer, characterized in that the freeze dryer comprises a drying chamber in which a freeze-dried object is freeze-dried, a vacuum pump for evacuating the drying chamber, a heating device for acquiring the weight of the freeze-dried object, and a weighing device for acting on the freeze-dried object; the method comprises the following steps:
acquiring the weight of the freeze-dried object for multiple times;
calculating a weight change parameter of the freeze-dried object;
and controlling the operation of the heating device according to the weight change parameter.
2. The method of claim 1, wherein said controlling operation of the heating device in accordance with the weight change parameter comprises:
starting the heating device and determining the heating value of the heating device according to the weight change parameter under the condition that the weight change parameter is greater than or equal to a weight change threshold; or alternatively, the first and second heat exchangers may be,
and turning off the heating device and turning off the vacuum pump when the weight change parameter is smaller than a weight change threshold.
3. The method according to claim 2, further comprising, after said determining a heating value of said heating device according to said weight change parameter:
acquiring the temperature of a freeze-dried object;
and turning off the heating device when the temperature of the freeze-drying object is greater than a temperature threshold.
4. The method according to claim 2, further comprising, after said determining a heating value of said heating device according to said weight change parameter:
acquiring the temperature of a freeze-dried object for multiple times;
the heating value of the heating device is adjusted according to the temperature of the freeze-drying object.
5. The method according to claim 4, wherein the adjusting the heating value of the heating device according to the change in the temperature of the lyophilization object includes:
reducing the heating value of the heating device when the temperature of the freeze-drying object increases; or alternatively, the first and second heat exchangers may be,
when the temperature of the freeze-dried object is reduced, the heating value of the heating device is increased.
6. The method of any one of claims 1 to 5, wherein the multiple acquisitions of the weight of the lyophilized object comprise:
starting the vacuum pump to vacuumize the drying chamber;
and under the condition that the vacuum pump is started for a preset time period, periodically acquiring the weight of the freeze-drying object.
7. The method of any one of claims 1 to 5, wherein calculating a weight change parameter of the lyophilization object comprises:
k＝m 1 -m 2 ，
wherein k is the weight variation parameter, m 1 For the weight of the freeze-dried object obtained last time, m 2 The weight of the freeze-dried object obtained this time is used.
8. An apparatus for controlling a freeze dryer comprising a processor and a memory storing program instructions, wherein the processor is configured to perform the method for controlling a freeze dryer according to any of claims 1 to 7 when the program instructions are run.
9. A freeze dryer, comprising:
a freeze dryer body defining a drying chamber therein, the drying chamber being for placing a freeze-dried object;
the vacuum pump is connected with the drying chamber and is used for vacuumizing the drying chamber;
the heating device is arranged on the freeze dryer body and used for providing sublimation heat for solid water in a freeze-drying object;
the weighing device is arranged on the freeze dryer body and used for acquiring the weight of a freeze-drying object; and, a step of, in the first embodiment,
the apparatus for controlling a freeze dryer according to claim 8, being mounted to the dryer body.
10. A storage medium storing program instructions which, when executed, perform the method for controlling a lyophilizer according to any one of claims 1 to 7.
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| CN202310207507.3A CN116222158A (en) | 2023-03-06 | 2023-03-06 | Method and device for controlling freeze dryer, freeze dryer and storage medium |
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| CN202310207507.3A CN116222158A (en) | 2023-03-06 | 2023-03-06 | Method and device for controlling freeze dryer, freeze dryer and storage medium |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117223807A (en) * | 2023-11-14 | 2023-12-15 | 山东农圣恒昌农业科技有限公司 | Preparation method of tomato fruit and vegetable beverage rich in lycopene |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117223807A (en) * | 2023-11-14 | 2023-12-15 | 山东农圣恒昌农业科技有限公司 | Preparation method of tomato fruit and vegetable beverage rich in lycopene |
| CN117223807B (en) * | 2023-11-14 | 2024-01-26 | 山东农圣恒昌农业科技有限公司 | Preparation method of tomato fruit and vegetable beverage rich in lycopene |
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