CN116218297A - Hydrophobic material for wearable sweat patch, and preparation method and application thereof - Google Patents

Hydrophobic material for wearable sweat patch, and preparation method and application thereof Download PDF

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CN116218297A
CN116218297A CN202211531593.5A CN202211531593A CN116218297A CN 116218297 A CN116218297 A CN 116218297A CN 202211531593 A CN202211531593 A CN 202211531593A CN 116218297 A CN116218297 A CN 116218297A
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polytetrafluoroethylene
stirring
patch
sealing
hydrophobic material
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CN116218297B (en
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毛红菊
林博
孙腾
周麟
武振华
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Shanghai Institute of Microsystem and Information Technology of CAS
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Shanghai Institute of Microsystem and Information Technology of CAS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C09D127/02—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment
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    • C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
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Abstract

The invention provides a hydrophobic material for a wearable sweat patch, and a preparation method and application thereof, wherein the preparation method comprises the following steps: s1: adding 1-2 g of polytetrafluoroethylene into a beaker filled with 60-100 mL of absolute ethyl alcohol, sealing by a sealing film, performing ultrasonic dispersion for 5-10 min, and stirring for 40-60 min to obtain a uniform polytetrafluoroethylene dispersion solution; s2: adding ammonia water, sealing by a sealing film, and stirring for 30-50 min; s3: adding 1-3 mL of tetraethyl silicate and 0.4-1.2 mL of fluorine-containing silane, sealing by a sealing film, and stirring for 24-32 h to obtain the fluorine-containing silane. The invention can realize the preparation of the coating only under normal temperature and normal pressure, not only can not change the characteristic of flexibility of the wearable sweat patch, but also greatly improve the problem of sweat residue of the existing wearable sweat patch, and avoid the influence of inconsistent errors caused by frequent patch replacement through repeated use of the patch.

Description

Hydrophobic material for wearable sweat patch, and preparation method and application thereof
Technical Field
The invention relates to the field of hydrophobic materials, in particular to a hydrophobic material for a wearable sweat patch, and a preparation method and application thereof.
Background
The wettability of a material surface depends on the level of surface energy and microstructure fineness of the material surface, and it is generally considered that a surface with a Contact Angle (CA) of water of more than 150 ° and a rolling angle of less than 10 ° is a superhydrophobic surface. The super-hydrophobic surface has wide application prospect in the fields of microfluidic systems, pollution prevention, self-cleaning, corrosion prevention, water prevention and the like due to the excellent performance of the super-hydrophobic surface.
A wearable sweat patch is a device that collects sweat based on microfluidic technology. The device is mainly manufactured based on a Polydimethylsiloxane (PDMS) structure in domestic and foreign researches, and a runner can accommodate a proper amount of sweat. When the sweat flows through different positions in the flow channel, physical and chemical reactions can occur at biochemical reaction sites which are pre-placed in the microfluidic channel. Through the results of the physicochemical reactions, the biomarker concentration condition in sweat components can be further analyzed, and the health state of the human body can be represented.
However, there are two problems with existing techniques for making wearable sweat patches: 1) For sweat patches worn for a long time, part of sweat can remain in the flow channel in the sweat collecting process, so that the influence on sweat components flowing in after the sweat components, especially when inorganic salt components such as sodium ions and potassium ions or organic matter components such as glucose and lactic acid in sweat before and after flowing in the flow channel are extremely large in phase difference, the detection result is greatly influenced; 2) The sweat residue effect continuous monitoring result can be solved by continuously replacing the sweat patch, but frequent replacement of the patch brings the effect of inconsistent errors of the patch, and the use cost of a user can be increased intangibly.
Disclosure of Invention
The invention aims to provide a hydrophobic material for a wearable sweat patch, and a preparation method and application thereof, so as to solve the problem that in the prior art, the measurement result is inaccurate because part of sweat is easy to remain in a runner.
In order to solve the technical problems, the invention adopts the following technical scheme:
according to a first aspect of the present invention there is provided a method of preparing a hydrophobic material for a wearable sweat patch, comprising the steps of: s1: adding 1-2 g of polytetrafluoroethylene into a beaker filled with 60-100 mL of absolute ethyl alcohol, sealing by a sealing film, performing ultrasonic dispersion for 5-10 min, and stirring for 40-60 min to obtain a uniform polytetrafluoroethylene dispersion solution; s2: adding ammonia water into the polytetrafluoroethylene dispersion solution, sealing by a sealing film, and stirring for 30-50 min to obtain an alkaline solution of polytetrafluoroethylene; s3: adding 1-3 mL of tetraethyl silicate and 0.4-1.2 mL of fluorine-containing silane into the polytetrafluoroethylene alkaline solution, sealing by a sealing film, and stirring for 24-32 h to obtain the PTFE@TEOS/F hydrophobic nanoparticle solution.
Preferably, in the step S1, after ultrasonic dispersion, the beaker is placed on a magnetic stirrer for stirring, and the stirring speed is 1800-2200 rpm.
Preferably, in the step S2, 4-6 mL of ammonia water and 6-10 mL of deionized water are added to the polytetrafluoroethylene dispersion solution.
Preferably, in step S3, the fluorine-containing silane is selected from: trichloro (1H, 2H-heptadecafluorodecane) silane, trichloro (1H, 2H-perfluorooctyl) silane any one or two of 1H, 2H-perfluoro octyl triethoxysilane and 1H, 2H-perfluoro decyl triethoxysilane.
In the step S3, the purity of the tetraethyl silicate and the fluorine-containing silane is more than 99 percent.
Preferably, in the step S3, the dosage ratio of the tetraethyl silicate to the fluorine-containing silane is (4-5) to 2.
Preferably, in the step S3, the dosage ratio of the tetraethyl silicate solution to the fluorosilane solution is 5:2.
Preferably, in step S3, the stirring speed is 800 to 1200rpm.
According to a preferred embodiment of the present invention, step S3 includes: the sealing film was opened and 1 to 3mL tetraethyl silicate (TEOS) (brand optional: innochem) and 400 to 1200. Mu.L of fluorosilane, including but not limited to: trichloro (1 h,2 h-heptadecafluorodecanyl) silane (brand-optional: adamas), trichloro (1 h,2 h-perfluorooctyl) silane (brand optional: one of Adamas), 1h,2 h-perfluorooctyl triethoxysilane (brand optional: adamas), 1h,2 h-perfluorodecyl triethoxysilane (brand optional: adamas) was added to the solution, the system was sealed again with a sealing film and stirring was continued on a magnetic stirrer at 1000rpm for 24-32 hours.
According to another preferred embodiment of the present invention, step S3 includes: 1-3 mL of tetraethyl silicate (brand optional: innochem), 200-600 mu L of trichloro (1H, 2H-perfluorooctyl) silane (brand optional: adamas) and 200-600 mu L of 1H, 2H-perfluorooctyl triethoxysilane (brand optional: adamas) are respectively added into the solution system by a pipetting gun, the system is sealed again by the sealing film, and stirring is continued on a magnetic stirrer at a rotating speed of 1000rpm for 24-32 hours.
According to a further preferred embodiment of the present invention, step S3 comprises: 1-3 mL of tetraethyl silicate (brand optional: innochem), 200-600 mu L of trichloro (1H, 2H-perfluorooctyl) silane (brand optional: adamas) and 200-600 mu L of 1H, 2H-perfluorooctyl triethoxysilane (brand optional: adamas) are respectively added into the solution system by a pipetting gun, the system is sealed again by the sealing film, and stirring is continued on a magnetic stirrer at a rotating speed of 1000rpm for 24-32 hours.
It will be appreciated that the above three preferred zonesExcept that the added fluorine-containing long chain has different length or different metabolite (ethanol or hydrogen chloride is produced), wherein the preparation method containing 1H, 2H-perfluoro octyl triethoxysilane can hydrolyze to produce ethanol, the remaining long chain is combined with silicon dioxide, and the two structures of trichloro (1H, 2H-perfluorooctyl) silane and trichloro (1H, 2H-heptadecafluorodecyl) silane are hydrolyzed to generate hydrogen chloride, and the remaining long chain is combined with the silicon dioxide. Meanwhile, the length of fluorine-containing long chains of two fluorosilanes containing perfluorooctyl groups in the name is less than that of trichloro (1H, 2H-heptadecafluorodecane group) silane by two CF 2 The chain length is shorter. However, it was found through the study of the present invention that the hydrophobic material prepared by any of the above schemes has almost no difference in properties. Therefore, the fluorine-containing silane in step S3 in the production method of the present invention is not limited to a specific kind, and either one or both of them may be selected.
According to a second aspect of the present invention there is provided a hydrophobic material for a wearable sweat patch made according to the above-described method of manufacture.
According to a third aspect of the present invention there is provided the use of a hydrophobic material in the field of wearable sweat patches, the hydrophobic material being applied to a microfluidic flow channel of a wearable sweat patch in any one of spray coating, drop coating, spin coating, dip coating, to reduce the surface energy of the material, form a surface layer with superhydrophobic properties, and reduce the liquid residue of the microfluidic flow channel in use.
According to the preparation method provided by the invention, the effect of the step S1 is to uniformly mix PTFE in a solution system so as to be fully contacted and combined with the generated nano particles in the subsequent reaction; step S2 is used for making the whole solution system alkaline, so that the hydrolysis of the tetraethyl silicate in the next step is facilitated; the function of step S3 is to graft fluorine-containing long chains on the silica produced by hydrolysis of tetraethyl silicate, the long chains being obtained by hydrolysis of fluorine-containing silanes.
Furthermore, the hydrophobic material is applied to the microfluidic flow channel of the wearable sweat patch in any mode selected from spraying, dripping, spin coating and dipping, after the solvent component in the hydrophobic material solution volatilizes, a surface layer with super-hydrophobic property is formed on the microfluidic flow channel, and the layer structure has good hydrophobic property and can be used for reducing the problem of liquid residue existing in the microfluidic flow channel in use.
The preparation method of the hydrophobic material for the wearable sweat patch provided by the invention has the following advantages compared with the prior art:
1) The water contact angle of the hydrophobic material prepared by the method reaches 159.9 degrees, the sliding angle is smaller than 1 degree, and the requirement of super-hydrophobic surface definition is met, so that the hydrophobic material provided by the invention is particularly suitable for the performance improvement of the micro-fluid channel surface of the wearable sweat patch;
2) Compared with the existing preparation method of the super-hydrophobic material, the preparation method of the super-hydrophobic material does not need high-temperature operation (see CN113321997A, CN 108997798A), the prepared structure can be more suitable for a micron-sized runner (see CN 108912985A) in a microfluidic structure, the operation flow is simpler (see CN 101805434A), the preparation of a coating can be realized only by using a solution-gel method at normal temperature and normal pressure, and the hydrophobic coating can be prepared on a prepared sweat patch by using modes such as spraying, spin coating and the like;
3) After the hydrophobic coating is sprayed on, the flexibility of the wearable sweat patch is not changed, compared with the prior art that the structure of the microfluidic flow channel is changed, a hard structure is added to improve the hydrophobic capability of the wearable sweat patch, and the flexibility of the wearable sweat patch is not changed structurally in the research work of reducing liquid residues (see CN 112280678A), the wearable sweat patch can still be used for being well attached to the skin surface after hydrophobic treatment, and the repeated use of the patch can be realized by reducing sweat residues.
In summary, according to the hydrophobic material for the wearable sweat patch, the preparation method and the application thereof provided by the invention, the preparation of the coating can be realized by using a solution-gel method under normal temperature and normal pressure without heating and pressurizing treatment, the preparation is more convenient and low in cost, the super-hydrophobic surface is formed on the surface of the structure modified by the hydrophobic material, the characteristics of flexibility of the wearable sweat patch can not be changed, the problem of sweat residue of the conventional wearable sweat patch is greatly improved, and the influence of inconsistent errors caused by frequent patch replacement is avoided through repeated use of the patch. In addition, the hydrophobic material prepared according to the present invention is not limited to wearable sweat patches, but can be extended to other fields.
Drawings
FIG. 1 is a flow chart of a method for preparing a hydrophobic material according to the present invention;
FIG. 2 is a graph showing the analysis result of surface morphology of the nanoparticle prepared by the present invention using Fourier transform infrared (FT-IR);
FIG. 3 is an AFM result obtained by photographing the nano-particles prepared by the present invention by AFM, wherein the left graph is an AFM image obtained by photographing, and the right graph A, B, C is a height dimension result analysis of three positions randomly selected in the left graph;
FIG. 4 is a TEM image of nanoparticles prepared according to the invention taken with a TEM;
fig. 5 shows the effect of the hydrophobic material prepared according to the present invention in the application of an actual microfluidic channel.
Detailed Description
The invention will be further illustrated with reference to specific examples. It should be understood that the following examples are illustrative of the present invention and are not intended to limit the scope of the present invention.
According to the present invention there is provided a method of preparing a hydrophobic material for a wearable sweat patch, the process flow diagram of which is shown in figure 1. Mainly comprises the following steps: s1: adding 1-2 g of polytetrafluoroethylene into a beaker filled with 60-100 mL of absolute ethyl alcohol, sealing by a sealing film, performing ultrasonic dispersion for 5-10 min, and stirring for 40-60 min to obtain a uniform polytetrafluoroethylene dispersion solution; s2: adding ammonia water into the polytetrafluoroethylene dispersion solution, sealing by a sealing film, and stirring for 30-50 min to obtain an alkaline solution of polytetrafluoroethylene; s3: adding 1-3 mL of tetraethyl silicate and 0.4-1.2 mL of fluorine-containing silane into the polytetrafluoroethylene alkaline solution, sealing by a sealing film, and stirring for 24-32 h to obtain the PTFE@TEOS/F hydrophobic nanoparticle solution.
Example 1
The preparation of the PTFE@TEOS/F hydrophobic nanoparticle solution comprises the following steps:
1) Firstly, 1g of Polytetrafluoroethylene (PTFE) micropowder (Aladin) is weighed by an electronic balance, added into a beaker filled with 60mL of absolute ethyl alcohol (great), the mixed solution is dispersed for 5 minutes by ultrasonic waves, a magnetic rotor with proper size is added into the beaker, and the beaker is sealed by a sealing film (AS-ONE) in a plastic mode to prevent the absolute ethyl alcohol in the beaker from volatilizing. The entire beaker was placed on a magnetic stirrer and stirring was continued at 2000rpm for 40-60 min to ensure uniform dispersion of the polytetrafluoroethylene in the solution.
2) Opening the sealing film, respectively injecting 4mL of ammonia water (great), 6mL of deionized water (18.2 megaohm) into the mixed system, replacing a new sealing film, sealing again, stirring for 30-50 minutes, and making the solution environment alkaline to promote the next step of hydrolysis of tetraethyl silicate and silicon dioxide.
3) The sealing film was opened, 1mL of tetraethyl silicate (TEOS) (innochem) and 400 μl of trichloro (1 h,2 h-heptadecafluorodecane) silane (Adamas) were added to the solutions, respectively, using a pipette, the system was sealed again with the sealing film, and stirring was continued on a magnetic stirrer at 1000rpm for 24 to 32 hours. This step requires stirring for 24 hours or more in order to be sufficiently stirred. And taking down the sealing film, obtaining liquid in the beaker, namely the prepared PTFE@TEOS/F hydrophobic nanoparticle solution, pouring the solution out of the beaker, and preserving the solution at normal temperature by using a centrifuge tube for later use.
Example 2
The preparation of the PTFE@TEOS/F hydrophobic nanoparticle solution comprises the following steps:
1) First, 2g of Polytetrafluoroethylene (PTFE) micropowder (aladin) was weighed by an electronic balance, added to a beaker containing 100mL of absolute ethanol, the mixed solution was dispersed with ultrasonic waves for 5 minutes, and a magnetic rotor of an appropriate size was added to the beaker, and a sealing film for a beaker (brand optional: AS-ONE) to prevent the evaporation of the absolute ethanol in the beaker. The entire beaker was placed on a magnetic stirrer and stirring was continued at 2000rpm for 40-60 min to ensure uniform dispersion of the polytetrafluoroethylene in the solution.
2) Opening the sealing film, respectively injecting 6mL of ammonia water and 10mL of deionized water (18.2 megaohms) into the mixed system, replacing a new sealing film, sealing again, stirring for 30-50 minutes, and making the solution environment alkaline so as to promote the next step of hydrolysis of the tetraethyl silicate and the silicon dioxide.
3) The sealing film was opened, 2mL of tetraethyl silicate (innochem), 300. Mu.L of fluorosilane-trichloro (1H, 2H-heptadecafluoro-decane) silane (Adamas), and 300. Mu.L of 1H, 2H-perfluorooctyl triethoxysilane (Adamas) were each added to the solution system by a pipette, the system was sealed again by the sealing film, and stirring was continued on a magnetic stirrer at 1000rpm for 24 to 32 hours. And taking down the sealing film, obtaining liquid in the beaker, namely the prepared PTFE@TEOS/F hydrophobic nanoparticle solution, pouring the solution out of the beaker, and preserving the solution at normal temperature by using a centrifuge tube for later use.
Example 3
The preparation of the PTFE@TEOS/F hydrophobic nanoparticle solution comprises the following steps:
1) Firstly, 2g of Polytetrafluoroethylene (PTFE) micropowder (Aladin) is weighed by an electronic balance, added into a beaker filled with 80mL of absolute ethyl alcohol (great), the mixed solution is dispersed for 5 minutes by ultrasonic waves, a magnetic rotor with proper size is added into the beaker, and a sealing film (AS-ONE) for the beaker is used for plastic packaging to prevent the absolute ethyl alcohol in the beaker from volatilizing. The entire beaker was placed on a magnetic stirrer and stirring was continued at 2000rpm for 40-60 min to ensure uniform dispersion of the polytetrafluoroethylene in the solution.
2) The sealing film is opened, 5mL of ammonia water (great) and 8mL of deionized water (18.2 megaohm) are respectively injected into the mixing system, a new sealing film is replaced, the sealing film is sealed again, and stirring is carried out for 30-50 minutes, so that the solution environment presents alkalinity to promote the next step of hydrolysis of tetraethyl silicate to silica.
3) The sealing film was opened and 3mL of tetraethyl silicate (brand-optional: innochem), 600 μl of trichloro (1H, 2H-perfluorooctyl) silane (Adamas), 600 μl of 1H, 2H-perfluorooctyl triethoxysilane (Adamas) were added to the solution system, the system was sealed again with a sealing film, and stirring was continued on a magnetic stirrer at 1000rpm for 24-32 hours. And taking down the sealing film, obtaining liquid in the beaker, namely the prepared PTFE@TEOS/F hydrophobic nanoparticle solution, pouring the solution out of the beaker, and preserving the solution at normal temperature by using a centrifuge tube for later use.
Example 4 measurement of Properties of hydrophobic Material
According to the study of the present invention, it was found that the hydrophobic materials prepared by the three modes of examples 1 to 3 are different only in the length of the added fluorine-containing long chain or in the metabolites (ethanol or hydrogen chloride production), and the material properties are hardly different. The water contact angle of the hydrophobic material is 159.9 degrees, the sliding angle is less than 1 degree, and the requirements of super-hydrophobic surface definition are met.
In order to better demonstrate the change of the functional groups which reduce the surface energy of the material during the nanoparticle formation process, the surface morphology of the nanoparticles prepared in example 1 above was analyzed by Fourier transform infrared (FT-IR) as shown in FIG. 2, wherein the infrared absorption peak of PTFE@TEOS/F nanoparticles was at 1245cm -1 And 1215cm -1 At the highest point, the infrared absorption peak obtained by simply modifying silica with fluorosilane (in the above-mentioned production steps, obtained in the steps 2) and 3)) was 1245cm -1 And 1215cm -1 The infrared absorption peak of the unmodified silica was lower and showed at 1245cm -1 And 1215cm -1 There is no infrared absorption peak in the vicinity. From the comparison of the three infrared absorption peaks, it can be deduced that the nanoparticle prepared according to the method of the present invention is PTFE@TEOS/F. The infrared shooting results of the silica and the prepared PTFE@TEOS/F nanoparticles are mainly shown, and two infrared absorption peaks are added from the shooting results, wherein the two infrared absorption peaks represent the presence of the added PTFE nanoparticles in the nanoparticles, and the two infrared absorption peaks are also positions of C-F modified on the silica by fluorosilane. From this, it was demonstrated that the invention successfully produced a PTFE@TEOS/F nanoparticles.
Meanwhile, in order to better characterize the microstructure of the hydrophobic nanoparticle, we photographed the nanoparticle with AFM and TEM, respectively. By dropping a hydrophobic coating onto a mica sheet, we have photographed AFM images, as shown in the left graph in fig. 3, and A, B, C in the right graph are three randomly selected positions, respectively, for determining the height of the surface topography protrusions on the surface of the material. By dropping the hydrophobic coating onto the carbon net, we photographed the particle size morphology of the hydrophobic nanoparticles using TEM, as shown in figure 4. By combining the two images for comparative analysis, it can be deduced that the height of the nanoparticles is between 1nm and 200 nm.
Further analysis shows that if the nanoparticles are attached in microfluidic channels with a common diameter of more than 10 μm, the nanoparticles do not hinder the transport of liquid while rejecting the liquid in the channels.
Example 5 application of hydrophobic Material to wearable sweat Patches
In order to test the application effect in a practical microfluidic structure, we also performed an application experiment of the hydrophobic material on a wearable sweat patch. It should be noted that the wearable sweat patch according to the present invention is mainly a device for collecting sweat made of PDMS (polydimethylsiloxane) and other materials by microfluidic technology, and is described in a great deal of literature both at home and abroad.
Firstly, the ptfe@teos/F hydrophobic nanoparticle solution prepared in example 1 above was mixed by shaking and sprayed on a common wearable sweat patch by spraying. After the solvent volatilizes, colored liquid is dripped into six branches of the flow channel by using a syringe, and the application effect is shown in fig. 5. After the liquid is dripped on the wearable patch, the liquid drop has a higher contact angle and a lower sliding angle on the patch due to the excellent hydrophobic property of the hydrophobic material prepared by the invention; then, the liquid drop is dragged to the middle part of the flow channel by the needle of the syringe, so that the colored liquid can not have obvious residue on the wearable sweat patch in the dragging process.
From this we infer that the ptfe@teos/F nanoparticles prepared according to the present invention not only can reduce the liquid residue in the microfluidic channels of wearable sweat patches, but also can reduce the high cost and inaccuracy caused by inconsistencies between patches in a recycling manner.
It should be appreciated that the application of the hydrophobic material to the microfluidic flow channels may be accomplished by any of the methods known to those skilled in the art, including spraying, dipping, spin coating, dipping, and the like.
The foregoing description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and various modifications can be made to the above-described embodiment of the present invention. All simple, equivalent changes and modifications made in accordance with the claims and the specification of the present application fall within the scope of the patent claims. The present invention is not described in detail in the conventional art.

Claims (10)

1. A method of preparing a hydrophobic material for a wearable sweat patch, comprising the steps of:
s1: adding 1-2 g of polytetrafluoroethylene into a beaker filled with 60-100 mL of absolute ethyl alcohol, sealing by a sealing film, performing ultrasonic dispersion for 5-10 min, and stirring for 40-60 min to obtain a uniform polytetrafluoroethylene dispersion solution;
s2: adding ammonia water into the polytetrafluoroethylene dispersion solution, sealing by a sealing film, and stirring for 30-50 min to obtain an alkaline solution of polytetrafluoroethylene;
s3: adding 1-3 mL of tetraethyl silicate and 0.4-1.2 mL of fluorine-containing silane into the polytetrafluoroethylene alkaline solution, sealing by a sealing film, and stirring for 24-32 h to obtain the polytetrafluoroethylene alkaline solution.
2. The method according to claim 1, wherein in step S1, the beaker is placed on a magnetic stirrer to stir after ultrasonic dispersion, and the stirring speed is set to 1800 to 2200rpm.
3. The method according to claim 1, wherein in step S2, 4 to 6mL of aqueous ammonia and 6 to 10mL of deionized water are added to the polytetrafluoroethylene dispersion solution.
4. The method according to claim 1, wherein in step S3, the fluorine-containing silane is selected from the group consisting of: trichloro (1H, 2H-heptadecafluorodecane) silane, trichloro (1H, 2H-perfluorooctyl) silane any one or two of 1H, 2H-perfluoro octyl triethoxysilane and 1H, 2H-perfluoro decyl triethoxysilane.
5. The method according to claim 1, wherein in step S3, the purity of the tetraethyl silicate and the fluorosilane is 99% or more.
6. The method according to claim 1, wherein in step S3, the ratio of the amount of the tetraethyl silicate to the amount of the fluorine-containing silane is (4-5) to 2.
7. The method according to claim 6, wherein in the step S3, the ratio of the tetraethyl silicate to the fluorosilane is 5:2.
8. The method according to claim 1, wherein in step S3, the stirring speed is set to 800 to 1200rpm.
9. A hydrophobic material for a wearable sweat patch made according to the method of any one of claims 1 to 8.
10. Use of a hydrophobic material according to claim 9 in the field of wearable sweat patches, characterized in that the liquid residue of the microfluidic flow channel in use is reduced by applying the hydrophobic material to the microfluidic flow channel of the wearable sweat patch in any one of the ways selected from spray coating, drop coating, spin coating, dip coating, forming a surface layer with superhydrophobic ability.
CN202211531593.5A 2022-12-01 Hydrophobic material for wearable sweat patch, and preparation method and application thereof Active CN116218297B (en)

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Publication number Priority date Publication date Assignee Title
CN103923540A (en) * 2014-04-22 2014-07-16 吴俊� Super-amphiphobic coating

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103923540A (en) * 2014-04-22 2014-07-16 吴俊� Super-amphiphobic coating

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