CN116218183A

CN116218183A - Disposable isolation plug easy to puncture and preparation method thereof

Info

Publication number: CN116218183A
Application number: CN202211649791.1A
Authority: CN
Inventors: 林清华; 向军
Original assignee: Ruijia Yixing Technology Co ltd
Current assignee: Ruijia Yixing Technology Co ltd
Priority date: 2022-12-21
Filing date: 2022-12-21
Publication date: 2023-06-06

Abstract

The invention relates to the technical field of isolating plugs, in particular to an IPC C08L7, and more particularly relates to a disposable isolating plug easy to puncture and a preparation method thereof. The isolating plug of the invention is prepared from the raw materials of high molecular polymer, softening agent, anti-aging agent, flowing agent, filler, titanium pigment and cross-linking agent. The invention reduces the friction force between the isolation plug and the needle tube and improves the anti-aging performance of the isolation plug through the preparation and synthesis of different components.

Description

Disposable isolation plug easy to puncture and preparation method thereof

Technical Field

The invention relates to the technical field of isolating plugs, in particular to an IPC C08L7, and more particularly relates to a disposable isolating plug easy to puncture and a preparation method thereof.

Background

The use of the indwelling needle can reduce the pain and the fear of injection caused by repeated venipuncture of patients, is also convenient for clinical emergency patients to take medicines, and reduces the workload of nurses, thereby being widely applied in clinic. In the indwelling needle, the isolating plug acts as a catheter assembly of the indwelling needle, affecting the performance of the indwelling needle.

The prior patent CN201922076843.0 discloses a isolating plug which is beneficial to penetration and is not easy to leak liquid, and illustrates the shape and structure of the isolating plug, but does not illustrate the constituent components of the isolating plug.

The prior patent CN201921623938.3 discloses a novel sealing isolation plug, and the isolation plug is reserved with a bidirectional channel, so that the problem that good sealing performance can be maintained after multiple punctures is solved. However, the friction between the needle cannula and the septum is not improved from the composition of the septum and the method of making.

At present, the isolating plug on the market has the problems of large friction force between the isolating plug and the needle, poor aging resistance and the like.

Disclosure of Invention

In order to solve the problems in the prior art, the first aspect of the invention provides a disposable isolation plug easy to puncture, which is prepared from the raw materials including high molecular polymer, softening agent, anti-aging agent, flowing agent, filler, titanium pigment and crosslinking agent.

Preferably, the isolating plug is prepared from the raw materials of 80-90 parts by weight of high molecular polymer, 1-5 parts by weight of softener, 0.01-1 part by weight of antioxidant, 0.1-3 parts by weight of flowing agent, 1-10 parts by weight of filler, 1-5 parts by weight of titanium pigment and 0.1-1 part by weight of cross-linking agent.

Preferably, the high molecular polymer is one or more of polycarbonate, natural rubber and styrene-butadiene rubber; further preferred is polycarbonate.

Preferably, the polycarbonate has a melt flow rate of 10g/10min at 190 ℃.

Preferably, the polycarbonate is available from Shanghai lane plasticization Co., ltd under the designation PC SC-1100UR.

Preferably, the softener is an alkane oil; further preferred is a naphthenic rubber oil.

Preferably, the kinematic viscosity of the naphthenic rubber oil at 40 ℃ is 5-50 mm ² S; further preferably, it is 32.87mm ² /s。

Preferably, the naphthenic base rubber oil is purchased from Henkexample corporation, model number 32.

Preferably, the weight ratio of the anti-aging agent to the high molecular polymer is (1-15): 870, a step of; further preferably, (3 to 9): 870.

the invention adds the components with the weight ratio of (3-9): 870, and the high molecular polymer, the tensile strength of the isolating plug is improved, and the compression resistance of the isolating plug is enhanced. The weight ratio of the additive in the invention is (3-9): 870, wherein the anti-aging agent is 1076 anti-aging agent and BHT264 anti-aging agent, and the 1076 anti-aging agent with a certain content can reduce thermal cracking and thermal crosslinking of the isolation plug caused by heat, reduce oxygen diffusion speed and activate oxidation reaction, thereby reducing oxidation reaction speed of the isolation plug; the BHT264 antioxidant can react with chain growth radicals in autoxidation to eliminate the radicals, thereby interrupting the chain reaction. Because the BHT264 anti-aging agent has 2 strong electron-withdrawing groups at the 2,6 positions, the antioxidant 264 has strong antioxidant effect. The two are combined with high molecular polymer to strengthen the antioxidant capacity of the isolating plug, further increase the tensile strength of the isolating plug, regulate the compression resistance and have no toxicity.

Preferably, the anti-aging agent comprises one or more of aniline compounds, alcohol ester compounds and phenol compounds; further preferred are alcohol ester compounds and phenol compounds.

Preferably, the anti-aging agent includes beta- (3, 5-di-tert-butyl-4-hydroxyphenylpropionate) and 2, 6-di-tert-butyl-4-methylphenol.

Preferably, the beta- (3, 5-di-tert-butyl-4-hydroxyphenyl octadecyl propionate) is available from Li Anlong supply chain management Co., ltd. Under the model 1076.

Preferably, 2, 6-di-tert-butyl-4-methylphenol is available from Hebei Pont titanium Co., ltd., model number BHT264.

Preferably, the anti-aging agent comprises 0.3 to 0.5 part by weight of beta- (3, 5-di-tert-butyl-4-hydroxyphenyl octadecyl propionate) and 0.1 to 0.3 part by weight of 2, 6-di-tert-butyl-4-methylphenol.

Preferably, the flow agent comprises one or more of erucamide and oleamide.

Preferably, the erucamide is 0.1-0.5 part by weight; more preferably, the amount of erucamide is 0.1 to 0.3 part.

Preferably, the weight ratio of the erucamide to the oleamide is (1-5): 5, a step of; further preferably, (1 to 3): 5.

preferably, the erucamide includes Crodamide ER-CH POWDER and Armoslip E.

Preferably, the weight ratio of the Crodamide ER-CH POWDER to the Armoslip E is (1-2): 1, a step of; further preferred is 1:1.

preferably, the Crodamide ER-CH POWDER is available from Shanghai Kaijin chemical Co.

Preferably, the Armoslip E is purchased from Yinuo chemical technology Co., guangzhou.

Preferably, the oleamide has a CAS number of 301-02-0.

Preferably, the oleamide is purchased from Shandong national chemical Co.

In the invention, 0.1 to 0.3 part of CRODAMIDE ER-CH-MB- (SI) and Armoslip E flowing agent are added into the polyurethane, so that the gloss, the anti-fouling and the elongation of the isolating plug can be improved, the vulcanization acceleration and the wear resistance are enhanced, and the ageing resistance of the isolating plug is enhanced. The inventor unexpectedly found that 0.1-0.3 part of erucic acid amide flowing agent is added in the preparation process of the isolation plug, thereby reducing static and dynamic friction factors, enhancing the hand feeling of the isolation plug and improving the surface smoothness of the isolation plug. Meanwhile, the addition of 0.1 to 0.3 part of erucamide flowing agent can reduce the rough feeling and the surface glossiness caused by the application of materials such as filler and the like.

In the invention, the weight ratio of the components is (1-3): 5 erucamide and oleamide, further enhancing the gloss, anti-fouling and elongation of the isolating plug and enhancing the ageing resistance of the isolating plug. The inventor creatively discovers that the adding weight ratio is (1-3): 5 erucamide and oleamide, further reduces static and dynamic friction factors, and increases the dispersibility of the filler, thereby improving the glossiness of the surface of the isolating plug and the ageing resistance of the isolating plug.

Preferably, the filler comprises one or more of silica, magnesium carbonate, mica powder; further preferred is silica.

Preferably, the silica is available from Shimadzu Ming Chemie (Shanghai) under the model ULTRASIL360.

Preferably, the titanium dioxide is purchased from Shandong Linguan fine chemical Co., ltd, and the model is R-902.

Preferably, the crosslinking agent is a peroxide; further preferred is di-t-butyldiisopropylbenzene peroxide.

Preferably, the cross-linking agent is Jiangsu Zhi Pai chemical Co., ltd, model BIBP.

The second aspect of the invention provides a method of making a disposable barrier plug that is easy to pierce, comprising the steps of:

s1: cleaning: cleaning the internal mixer, the open mill, the painting tray and other needed tools, and keeping clean and tidy;

s2: plasticating: (1) putting a high molecular polymer into an internal mixer;

(2) The cooling water is closed, the rotating speed is 40-60 r/min, and the plasticating temperature is about 130-140 ℃;

s3: mixing: (1) Opening cooling water, taking cooled plasticated rubber, and putting the plasticated rubber into an internal mixer;

(2) Continuously adding an anti-aging agent into the internal mixer, and mixing; premixing a softening agent, a flowing agent, a filling agent and titanium dioxide, and uniformly stirring to form a premix;

(3) Adding premix into an internal mixer, and mixing;

s4: open mill: (1) After the rubber is cooled, adding a cross-linking agent, and uniformly mixing in an open mill;

(2) And packing the triangular bag for 3-5 times, and adjusting the required thickness to obtain the tablet.

Advantageous effects

1. In the invention, 0.1 to 0.3 part of CRODAMIDE ER-CH-MB- (SI) and Armoslip E flowing agent are added into the polyurethane, so that the gloss, the anti-fouling and the elongation of the isolating plug can be improved, the vulcanization acceleration and the wear resistance are enhanced, and the ageing resistance of the isolating plug is enhanced.

2. In the invention, the weight ratio of the components is (1-3): 5 erucamide and oleamide, further enhancing the gloss, anti-fouling and elongation of the isolating plug and enhancing the ageing resistance of the isolating plug.

3. The invention adds the components with the weight ratio of (3-9): 870, and the high molecular polymer, the tensile strength of the isolating plug is improved, and the compression resistance of the isolating plug is enhanced.

4. In the invention, the disposable isolation plug easy to puncture is synthesized by compounding the components, and has the characteristics of small friction force, smooth appearance, strong aging resistance, no toxicity and the like

Detailed Description

Example 1

The first aspect of the embodiment provides a disposable isolation plug easy to puncture, which is prepared from the following raw materials, by weight, 87 parts of polyurethane PC SC-1100UR, 5 parts of cycloalkyl rubber oil, 0.5 part of anti-aging agent 1076, 0.3 part of anti-aging agent BHT264, 0.3 part of flowing agent Crodamide ER-CH POWDER, 0.1 part of flowing agent Armoslip E, 0.5 part of oleamide, 10 parts of silicon dioxide, 2.5 parts of titanium dioxide and 0.8 part of crosslinking agent BIBP.

The polycarbonates were purchased from Shanghai lane plasticization Co.

The cycloalkyl rubber oil is purchased from Hendelia Miquel commercial Co.

The anti-aging agent 1076 was purchased from Li Anlong supply chain management limited.

The antioxidant BHT264 was purchased from Hebei Pont titanium Co.

The Crodamide ER-CH POWDER is available from Shanghai Kailn chemical Co.

The Armoslip E was purchased from Yino chemical technology Co., ltd.

The CAS number of the oleamide is 301-02-0.

The oleamide was purchased from Shandong national chemical Co.

The silica was purchased from Shinewgeneral Ming Chemie (Shanghai).

The titanium dioxide is purchased from Shandong Linguan fine chemical industry Co.

The cross-linking agent is Jiangsu Zhi chemical Co.

The embodiment provides a preparation method of a disposable isolation plug easy to puncture, which comprises the following steps:

s2: plasticating:

(1) 87 parts of PC SC-1100UR are put into a 20L internal mixer;

(2) The cooling water is closed, the rotating speed is 60r/min, and the plasticating temperature is about 130-140 ℃;

s3: mixing:

(1) Opening cooling water, taking 13kg of cooled plasticated rubber, and putting into a 20L internal mixer;

(2) Continuously adding 0.4 part of anti-aging agent 1076 and 0.2 part of anti-aging agent BHT264 into an internal mixer, and mixing for 1min; premixing 1.5 parts of naphthenic rubber oil, 0.1 part of flowing agent Crodamide ER-CH POWDER, 0.1 part of flowing agent Armoslip E, 0.5 part of oleamide, 7 parts of silicon dioxide and 2.5 parts of titanium dioxide, and uniformly stirring to form a premix;

(3) Adding premix into an internal mixer, and mixing for 4min;

s4: open mill:

(1) After the rubber is cooled, adding 0.4 part of a cross-linking agent BIBP, and uniformly mixing;

(2) Packing the triangular bag for 5 times, and adjusting the required thickness to obtain the tablet.

Example 2

The first aspect of the embodiment provides a disposable isolation plug easy to puncture, which is prepared from the following raw materials, by weight, 80 parts of polyurethane PC SC-1100UR, 5 parts of cycloalkyl rubber oil, 0.3 part of anti-aging agent 1076, 0.1 part of anti-aging agent BHT264, 0.1 part of flowing agent Crodamide ER-CH POWDER, 0.5 part of flowing agent Armoslip E, 0.5 part of oleamide, 10 parts of silicon dioxide, 3 parts of titanium dioxide and 0.5 part of cross-linking agent BIBP.

The polycarbonates were purchased from Shanghai lane plasticization Co.

The cycloalkyl rubber oil is purchased from Hendelia Miquel commercial Co.

The antioxidant BHT264 was purchased from Hebei Pont titanium Co.

The Crodamide ER-CH POWDER is available from Shanghai Kailn chemical Co.

The Armoslip E was purchased from Yino chemical technology Co., ltd.

The CAS number of the oleamide is 301-02-0.

The oleamide was purchased from Shandong national chemical Co.

The silica was purchased from Shinewgeneral Ming Chemie (Shanghai).

The cross-linking agent is Jiangsu Zhi chemical Co.

s2: plasticating:

(1) 80 parts of PC SC-1100UR is put into a 20L internal mixer;

(2) The cooling water is closed, the rotating speed is 60r/min, and the plasticating temperature is about 135 ℃;

s3: mixing:

(2) Adding 0.3 part of an anti-aging agent 1076 and 0.1 part of anti-aging agent BHT264, and mixing for 1min; premixing 1 part of naphthenic rubber oil, 0.05 part of flowing agent Crodamide ER-CH POWDER, 0.05 part of flowing agent Armoslip E, 0.5 part of oleamide, 10 parts of silicon dioxide and 5 parts of titanium dioxide, and uniformly stirring to form premix;

(3) Adding premix, and mixing for 4min;

s4: open mill:

(1) After the rubber is cooled, adding 0.1 part of a cross-linking agent BIBP, and uniformly mixing;

Example 3

The first aspect of the embodiment provides a disposable isolation plug easy to puncture, which is prepared from the following raw materials, by weight, 90 parts of PC SC-1100UR, 5 parts of cycloalkyl rubber oil, 0.5 part of anti-aging agent 1076, 0.3 part of anti-aging agent BHT264, 0.25 part of flowing agent Crodamide ER-CH POWDER, 0.25 part of flowing agent Armoslip E, 0.5 part of oleamide, 10 parts of silicon dioxide, 1 part of titanium pigment and 1 part of crosslinking agent BIBP.

The polycarbonates were purchased from Shanghai lane plasticization Co.

The cycloalkyl rubber oil is purchased from Hendelia Miquel commercial Co.

The antioxidant BHT264 was purchased from Hebei Pont titanium Co.

The Crodamide ER-CH POWDER is available from Shanghai Kailn chemical Co.

The Armoslip E was purchased from Yino chemical technology Co., ltd.

The CAS number of the oleamide is 301-02-0.

The oleamide was purchased from Shandong national chemical Co.

The silica was purchased from Shinewgeneral Ming Chemie (Shanghai).

The cross-linking agent is Jiangsu Zhi chemical Co.

s2: plasticating:

(1) 90 parts of PC SC-1100UR is put into a 20L internal mixer;

s3: mixing:

(2) Continuously adding 0.5 part of anti-aging agent 1076 and 0.3 part of anti-aging agent BHT264 into an internal mixer, and mixing for 1min; premixing 2 parts of naphthenic rubber oil, 0.25 part of flowing agent Crodamide ER-CH POWDER, 0.25 part of flowing agent Armoslip E, 0.5 part of oleamide, 10 parts of silicon dioxide and 1 part of titanium dioxide, and uniformly stirring to form premix;

(3) Adding premix into an internal mixer, and mixing for 4min;

s4: open mill:

(1) After the rubber is cooled, adding 1 part of a cross-linking agent BIBP, and uniformly mixing;

Comparative example 1

The embodiment of comparative example 1 is the same as in example 1, except that the antioxidant is 0.6 part of beta- (3, 5-di-tert-butyl-4-hydroxyphenylpropionate) and no antioxidant 2, 6-di-tert-butyl-4-methylphenol is contained.

Comparative example 2

The embodiment of comparative example 2 is the same as in example 1 except that the antioxidant is 0.6 part of 2, 6-di-t-butyl-4-methylphenol and does not contain stearyl β - (3, 5-di-t-butyl-4-hydroxyphenyl propionate).

Comparative example 3

The embodiment of comparative example 3 is the same as in example 1, except that the antioxidant is 1 part of the antioxidant 1076 and 1 part of the antioxidant BHT264.

Comparative example 4

The embodiment of comparative example 4 is the same as in example 1 except that the flow agent is 0.5 parts erucamide, 6 parts oleamide.

Comparative example 5

The embodiment of comparative example 5 is the same as in example 1, except that the polyurethane PC SC-1100UR is 120 parts.

Performance testing

1. The hardness of the resulting separators of examples 1-3 was measured according to the ISO 48-4:2018 standard, at 25℃and 60℃for 8 days, 16 days, 24 days, respectively. The results are reported in Table 1.

2. The relative densities of the prepared separators of examples 1 to 3 were measured according to the method of ISO 2781 GB/T533-2008 standard, respectively, at 25℃and 60℃for 8 days, 16 days, and 24 days. The results are reported in Table 2.

3. The tensile strength, elongation at break, 100% modulus, 300% modulus and tensile modulus of the resulting separators of examples 1 to 3 were measured according to the method of ISO 37GB/T533-2009 standard, respectively, at 25℃and 60℃for 8 days, 16 days and 24 days. The results are reported in Table 3.

4. The tear strength of the prepared separators of examples 1 to 3 was measured according to the method of ISO 34-1/GB/T529 standard, measured at 25℃and stored at 60℃for 8 days, 16 days, 24 days, respectively. The results are reported in Table 4.

5. The compression set capacities of the prepared separators of examples 1 to 3 were measured according to the method of ISO 815-1/GB/T7759.1-2015, respectively, at 25℃and 60℃for 8 days, 16 days, and 24 days. The results are reported in Table 5.

6. The tensile strength and elongation at break of the resulting separators of examples 1 to 3 and comparative examples 1 to 5 were measured according to the method of ISO 37GB/T533-2009 standard, measured at 25℃and stored at 60℃for 24 days, respectively. The results are reported in Table 6.

TABLE 1

TABLE 2

TABLE 3 Table 3

TABLE 4 Table 4

TABLE 5

TABLE 6

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Claims

1. The disposable isolating plug is characterized by comprising the following raw materials of high-molecular polymer, softening agent, anti-aging agent, flowing agent, filler, titanium pigment and crosslinking agent; the flow agent comprises one or more of erucamide and oleamide.

2. The disposable easy penetration isolation plug of claim 1, wherein the high molecular polymer is one or more of polycarbonate, natural rubber, styrene butadiene rubber.

3. The disposable, penetrable, barrier plug of claim 1, wherein said softening agent is an alkane oil.

4. The disposable easy penetration isolation plug of claim 1, wherein the anti-aging agent comprises one or more of aniline compounds, alcohol esters compounds, phenol compounds.

5. The disposable, easy-to-puncture spacer of claim 1, wherein the weight ratio of the anti-aging agent to the high molecular polymer is (1-15): 870.

6. the disposable easy penetration isolation plug of claim 1 wherein the erucamide is 0.1 to 0.5 parts by weight erucamide.

7. The disposable, penetrable, barrier plug of claim 1, wherein the weight ratio of erucamide to oleamide is (1-5): 5.

8. the disposable, penetrable spacer according to claim 1, wherein said filler comprises one or more of silica, magnesium carbonate, mica powder.

9. The disposable, penetrable spacer according to claim 1, wherein said cross-linking agent is a peroxide.

10. A method of making a disposable, penetrable spacer according to any of claims 1 to 9, comprising the steps of:

s2: plasticating: (1) putting a high molecular polymer into an internal mixer;

(2) The cooling water is closed, the rotating speed is 40-60 r/min, and the plasticating temperature is about 120-140 ℃;

(3) Adding premix into an internal mixer, and mixing;

s4: open mill: (1) adding a cross-linking agent after the rubber is cooled, and uniformly mixing;