CN116211359B - Gene tissue sample sampling detection system - Google Patents

Abstract

The invention relates to a gene tissue sample sampling and detecting system, which comprises a shell, wherein the shell is of a rectangular structure with two open ends and a hollow inside, a glass carrying groove is formed in the lower end of the inside of the shell, a glass slide is arranged in the glass carrying groove, a supporting sheet unit is arranged at the upper end of the shell, a cover glass is arranged on the supporting sheet unit, an extending plate is symmetrically arranged at the opening of one side of the shell up and down, a width adjusting unit is arranged between the extending plates, a sampling unit is also arranged on the extending plate, and a detecting unit is arranged at one side of the shell far away from the extending plate; the invention can solve the following problems in the process of sampling and detecting the skin surface in the prior art: the skin scraping cutter is easy to contact healthy skin in the process of scraping diseased skin; the hand-held slide glass is easy to shake in the process of carrying the sample, so that the sample is easy to spill, the efficiency of sampling the surface of the skin is reduced, and the spilled sample is easy to adhere to healthy skin and cause infection to the healthy skin.

Description

Gene tissue sample sampling detection system

Technical Field

The invention relates to the field of gene detection, in particular to a gene tissue sample sampling detection system.

Background

The gene detection is a technology for detecting DNA through blood, other body fluids, human tissues or cells, and is a method for detecting DNA molecular information in cells of a detected person through specific equipment and analyzing the type of the gene and the gene defect contained in the DNA molecular information and whether the expression function of the gene defect is normal or not, so that people can clearly cause the disease or predict the risk of the body suffering from a certain disease; the sampling of the gene tissue is not only aimed at blood and cells, but also aimed at skin tissue of skin patients, and the etiology can be more easily known by sampling and detecting the skin of the human body suffering from skin diseases.

However, many patients suffering from skin diseases have a risk of infection, so that a protection means is particularly important in the process of sampling and detecting the skin of the patients suffering from skin diseases. The prior art generally has the defects that a sampling person holds a glass slide by one hand, places the glass slide on the lower side of a lesion area on skin for receiving, then scrapes and samples the lesion skin by adopting the other hand with a scraping cutter, and the process has the following defects;

1. the hand-held skin scraping tool also easily enables the tool to contact healthy skin in the process of scraping diseased skin, so that the problem that the healthy skin is infected due to contact with the skin scraping tool is easily caused, and the problem aggravates the illness state of a patient.

2. The problem that hand slide glass was rocked easily in the in-process of accepting the sample takes place to outwards spill easily to lead to the sample, on the one hand reduced the efficiency of sampling skin surface, on the other hand the sample that spills still glues on healthy skin and causes the infection to it easily.

Thus, under the above stated point of view, there is room for improvement in the prior art for sampling the surface of human skin using a manual hand held slide and a skin scraping cutter.

Disclosure of Invention

In order to solve the problems, the invention provides a gene tissue sample sampling and detecting system which comprises a shell, wherein the shell is of a rectangular structure with two open ends and hollow inside, a glass carrying groove is formed in the lower end of the inside of the shell, a glass carrier is arranged in the glass carrying groove, a supporting sheet unit is arranged at the upper end of the shell, a cover glass is arranged on the supporting sheet unit, an extending plate integrally formed with the opening of one side of the shell is symmetrically arranged at the upper and lower parts of the opening of the side of the shell, a width adjusting unit is arranged between the extending plates, a sampling unit positioned at the inner side of the width adjusting unit is also arranged on the extending plate, and a detecting unit for detecting is arranged at one side of the shell away from the extending plate.

The sampling unit including seting up the slip logical groove in the casing upper end and set up the track that slides on slipping logical groove, all roll in the track and be provided with spacing wheel, rotate between the spacing wheel and be provided with driven cover, slip on the driven cover and wear to be equipped with the lifter, the lifter upper end rotates and is provided with the operation handle, the lifter lower extreme is provided with the installation medium plate, the installation medium plate upper end is provided with the slip curb plate of L shape structure through sliding fit's mode symmetry, installation medium plate and slip curb plate lower extreme are provided with the sampling end, be provided with between the vertical hem of slip curb plate upper end and support and press the spring pole.

Preferably, the sampling end include sampling scraper blade and sampling curb plate, the sampling scraper blade sets up in the installation medium plate lower extreme through detachable mode, slip curb plate lower extreme all is provided with the sampling curb plate of laminating mutually with the sampling scraper blade through detachable mode, and the lower extreme of sampling curb plate and sampling scraper blade all inclines to the one side of keeping away from detection device.

Preferably, the sample scraping device further comprises a sample scraping unit which is arranged in the sliding track and used for transferring samples sampled by the sampling end to a glass slide, the sample scraping unit comprises a sliding plate, a scraping rod, an operating plate, a scraping plate, a sliding scraping plate, a magnet block and a reset pressure spring rod, the sliding plate of the 'king' -shaped structure is arranged between the sliding track, the scraping rod is arranged on the sliding plate in a vertically sliding fit mode, the operating plate on the upper side of the sliding track is arranged at the upper end of the scraping rod, the scraping plate is arranged at the lower end of the scraping rod, the sliding scraping plate is arranged on one side, close to the installation middle plate, of the scraping plate, the sliding scraping plate and the lower end of the scraping plate are inclined towards one side, close to the installation middle plate, the magnet block is arranged at the upper end of the sliding scraping plate, and the reset pressure spring rod is arranged between the magnet blocks.

Preferably, the width adjusting unit comprises a width adjusting plate, limiting protrusions, triangular baffle strips, limiting plates, abutting bolts and rotating blocks, the width adjusting plate of the L-shaped structure is symmetrically and vertically arranged on one side, close to the extending plates, of the inside of the shell in a sliding fit mode, limiting protrusions are symmetrically arranged at the upper end and the lower end of the opposite sides of the width adjusting plate, the triangular baffle strips attached to the left ends of the width adjusting plates are arranged at the upper ends of the extending plates of the lower sides, limiting plates used for limiting the width adjusting plates are further arranged between the upper side wall and the lower side wall of the shell, abutting bolts used for limiting the width adjusting plates are arranged at the upper ends of the shell in a penetrating mode in a threaded fit mode, and the rotating blocks located at the upper ends of the shell are sleeved on the outer side faces of the abutting bolts.

Preferably, the device further comprises a limiting unit which is convenient for enabling the sample scraping unit to move and reset towards one side close to the sampling unit, the limiting unit comprises a storage groove, a limiting sliding plate and a magnetic attraction block, a storage groove positioned at a corner is formed in one side, close to the detection device, of the width adjusting plate, the limiting sliding plate is arranged in the storage groove in a sliding mode, and the limiting sliding plate is provided with the magnetic attraction block which penetrates through the storage groove and corresponds to the magnet block.

Preferably, the support piece unit include slip logical groove, driven slider, lift push rod, fixer, press from both sides the glass strip, press from both sides glass lower extreme and locking latch segment, slip logical groove symmetry is offered in the casing upper end, slip logical inslot all slides and is provided with driven slider, vertical slip wears to be equipped with the lift push rod on the driven slider, be provided with the fixer on the lift push rod, the lift push rod lower extreme passes driven slider and is provided with the glass strip that presss from both sides that is connected with the cover glass, and press from both sides glass strip lower extreme face and be zigzag structure, slide both sides are provided with the glass strip that presss from both sides unsmooth complex of glass strip down, clamp glass lower extreme right side has been offered and has been blocked the recess of inserting, slip wears to be equipped with the locking latch segment that is located the card and inserts the recess on the casing.

Preferably, the fixer comprises a plug rod sleeve block, a plug block and a linkage bar, wherein the plug rod sleeve block is arranged at the upper end of the shell in a sliding way and is connected with the driven sliding block, a plug-in groove is formed in the lower side of the lifting push rod, the plug rod sleeve block is provided with the plug block which is arranged in the corresponding plug-in groove in a sliding way, and the linkage bar is further arranged between the upper ends of the lifting push rod.

Preferably, still including the folding support piece unit that is arranged in the support from the outside slide glass of roll-off in the casing, folding support piece unit include support glass strip, bearing groove, connecting rod and shape inserted block, support glass strip sets up the one side of keeping away from the extension board through the hinge symmetry in the casing lower extreme, support groove has been seted up to the opposite side of support glass strip upper end, and is provided with the connecting rod between the support glass strip, has seted up grafting recess on the casing, slide on the support glass strip and be provided with shape inserted block, shape inserted block upper end is located grafting recess.

Preferably, the plugging device further comprises a plugging unit for plugging the opening on the right side of the shell, wherein the plugging unit comprises a side baffle and a glass passing through groove, the side baffle is vertically arranged at the opening of one end of the shell far away from the extension plate, the side baffle is provided with the glass passing through groove corresponding to the cover glass and the glass clamping strip, and the distance between the side baffle and the lower side wall of the shell corresponds to the thickness of the glass slide and the cover glass.

Preferably, the detecting unit comprises a supporting frame, a rectangular frame, an adjusting slide plate and a detector, wherein the supporting frame with a -shaped structure is arranged at the upper end of the right side of the side baffle, the rectangular frame is arranged on the inner side of the supporting frame in a sliding mode, the adjusting slide plate is arranged on the inner side of the rectangular frame in a sliding mode, and the detector for observing and detecting is arranged on the adjusting slide plate.

In summary, the present application includes at least one of the following beneficial technical effects:

1. according to the invention, the width adjusting unit is matched with the sampling unit, so that the sampling end is prevented from contacting healthy skin in the sampling process as much as possible, the problem that the healthy skin is infected due to contacting the sampling end in the sampling process can be avoided, and the protection effect in the sampling process is improved.

2. According to the invention, the width adjusting unit is matched with the shell, so that a lesion area on the skin can be covered in the process of sampling the skin surface by the sampling unit, on one hand, the samples scraped from the skin can be prevented from being scattered, and the efficiency of sampling the samples on the skin surface is improved; on the other hand, the problem that the healthy skin is infected due to the fact that the collected sample falls on the healthy skin can be avoided.

Drawings

The invention will be further described with reference to the drawings and examples.

Fig. 1 is a schematic structural view of the present invention.

Fig. 2 is a schematic view of the structure of the present invention (seen from left to right).

Fig. 3 is a schematic diagram of the structure of the width adjusting unit of the present invention.

Fig. 4 is a schematic diagram of the structure of the sampling unit of the present invention.

Fig. 5 is an enlarged view of the invention at a in fig. 4.

Fig. 6 is a schematic structural view of the sample scraping unit of the present invention.

Fig. 7 is an enlarged view of the invention at B in fig. 6.

Fig. 8 is a schematic structural view of the blade unit of the present invention.

Fig. 9 is a schematic view of the structure of the folded blade unit of the present invention.

Fig. 10 is a schematic structural view of the plugging unit of the present invention.

FIG. 11 is a schematic diagram of the structure of the detecting unit of the present invention.

In the figure, 1, a shell; 10. a glass slide; 11. a cover slip; 12. an extension plate;

2. a blade supporting unit; 20. sliding through grooves; 21. a driven slide block; 22. lifting the push rod; 24. clamping glass strips; 25. clamping glass and blanking; 26. locking the insert block;

23. a holder; 230. a plug rod sleeve block; 231. a plug block; 232. a linkage bar;

3. a width adjusting unit; 30. a width adjusting plate; 31. a limit protrusion; 32. a triangular barrier strip; 33. a limiting plate; 34. abutting the bolt; 35. a rotating block;

4. a sampling unit; 40. a sliding through groove; 41. a slip rail; 42. a limiting wheel; 43. a driven sleeve; 44. a lifting rod; 45. an operating handle; 46. installing a middle plate; 47. sliding the side plates; 49. pressing the spring rod;

48. a sampling end; 480. a sampling scraper; 481. a sampling side plate;

5. a detection unit; 50. a support frame; 51. a rectangular frame; 52. adjusting the sliding plate; 53. a detector;

6. a sample scraping unit; 60. a slip plate; 61. a scraping rod; 62. an operation panel; 63. a scraping plate; 64. a sliding scraper; 65. a magnet block; 66. resetting the compression spring rod;

7. a limit unit; 70. a storage groove; 71. a limit sliding plate; 72. a magnetic suction block;

8. folding a supporting sheet unit; 80. a glass supporting strip; 81. a support groove; 82. a connecting rod; 83. shaped inserts;

9. a plugging unit; 90. side baffles; 91. and a glass passing groove.

Detailed Description

Embodiments of the invention are described in detail below with reference to fig. 1-11, but the invention can be implemented in a number of different ways, which are defined and covered by the claims.

The embodiment of the application discloses a gene tissue sample sampling and detecting system, which is mainly applied to the process of collecting samples from the surface of human skin and detecting the samples, and can avoid the problem that the healthy skin is infected due to the contact of the tool in the process of sampling as far as possible due to the technical effect that the tool for sampling is contacted with the healthy skin in the process of sampling; furthermore, the gene tissue sample sampling detection system can cover the lesion area on the skin during sampling, so that the problem that the healthy skin is infected due to the fact that the collected sample falls on the healthy skin can be avoided.

Embodiment one:

referring to fig. 1 and 2, the gene tissue sample sampling and detecting system includes a housing 1, wherein the housing 1 has a rectangular structure with two open ends and a hollow interior, and the housing 1 is made of transparent material, so as to facilitate the observation of the interior of the housing 1; the glass carrier groove has been seted up to the inside lower extreme of casing 1, is provided with slide glass 10 in the glass carrier groove, and slide glass 10 can be used to carry out the bearing to the sample after the sampling to follow-up observation detects the sample, casing 1 upper end is provided with holds in the palm piece unit 2, holds in the palm piece unit 2 and is provided with coverslip 11, holds in the palm piece unit 2 can fix coverslip 11 at the inside upside of casing 1, holds in the palm piece unit 2 can also drive coverslip 11 downwardly moving to slide glass 10 upper end.

Extension plates 12 integrally formed with the extension plates are symmetrically arranged at the opening of one side of the shell 1 from top to bottom, a width adjusting unit 3 is arranged between the extension plates 12, and the width adjusting unit 3 can adjust the size of the opening at the left end of the shell 1 so as to adapt to lesion areas with different sizes on skin; the extension plate 12 is also provided with a sampling unit 4 positioned at the inner side of the width adjusting unit 3, and the sampling unit can collect samples from the skin of a human body; the casing 1 is provided with the detecting element 5 that is used for observing and detecting the sample far away from the one side of extension board 12, can observe and detect the different positions on slide glass 10 through detecting element 5 to the pathological change situation of sample is convenient for know.

When the device is used, the adjusting unit 3 is required to be adjusted according to the pathological change area on the skin surface of a human body, so that the opening at the left end of the shell 1 can correspond to the pathological change area on the skin surface, then the left end of the shell 1 is sleeved on the outer side of the pathological change area on the skin, then the pathological change area on the skin is scraped and sampled by the sampling unit 4, in the process, the width adjusting unit 3 can prevent samples collected from the skin from falling onto healthy skin, and thus the problem that the healthy skin area is infected due to contact with the pathological change samples can be avoided, and the problem that the samples collected from the pathological change skin scatter around in the moving process can be avoided by the shell 1; after the sample falls to the upper end of the glass slide 10, the glass slide 11 is driven by the support sheet unit 2 to move downwards to cover the upper end of the glass slide 10, the glass slide 10 and the glass slide 11 are driven by the support sheet unit 2 to move rightwards to the lower end of the detection unit 5, and then the sample can be observed and detected by the detection unit 5.

Referring to fig. 3, a width adjusting unit 3 in the present application; specifically, the width adjusting unit 3 includes a width adjusting plate 30, a limiting protrusion 31, a triangular barrier strip 32, a limiting plate 33, a tightening bolt 34 and a rotating block 35, the width adjusting plate 30 with an l-shaped structure is symmetrically and vertically arranged at one side of the casing 1, which is close to the extending plate 12, in a sliding fit manner, a range formed by the coordination of a folded edge at the left end of the width adjusting plate 30 and the extending plates 12 at the upper side and the lower side is a sampling area, and the sampling area is used for being sleeved outside a lesion area on the skin.

The upper and lower both ends symmetry that width adjustment board 30 was opposite to each other is provided with spacing arch 31, the extension board 12 upper end of downside is provided with the triangle blend stop 32 that laminates mutually with width adjustment board 30 left end, triangle blend stop 32 also laminates skin when the sample district cover is in the regional outside of pathological change on skin, and in the in-process of scraping the sample from skin at follow-up sampling mechanism, can fall to inside casing 1 after the sample falls on triangle blend stop 32, and triangle blend stop 32 also can block the left side of casing 1 lower extreme, thereby can avoid the problem that the sample that is scraped outwards drops from extension board 12 left side, further reduced healthy skin and infected probability because of contacting pathological change sample.

A limiting plate 33 for limiting the width adjusting plate 30 is further arranged between the upper side wall and the lower side wall of the shell 1, the limiting plate 33 can limit the left side surface of the width adjusting plate 30, and the limiting protrusion 31 can prevent the width adjusting plate 30 from being separated from the shell 1 during the forward and backward movement adjustment; in order to be convenient for fix the width adjusting plate 30 that is adjusted through removing, just wear to be equipped with the tight bolt 34 that supports that is used for spacing to width adjusting plate 30 through screw-thread fit's mode in casing 1 upper end, support tight bolt 34 lateral surface on the cover be equipped with the turning block 35 that is located casing 1 upper end, be convenient for carry out manual rotation to tight bolt 34 through turning block 35.

With reference to fig. 4 and 5, a sampling unit 4 for taking a sample from the skin surface in a scraping manner is shown; specifically, the sampling unit 4 includes a sliding through groove 40, a sliding rail 41, a limiting wheel 42, a driven sleeve 43, a lifting rod 44, an operation handle 45, a mounting middle plate 46, a sliding side plate 47, a sampling end 48 and a pressing spring rod 49, the upper end of the shell 1 is provided with the sliding through groove 40, the sliding rail 41 is symmetrically arranged in the sliding through groove 40, the limiting wheels 42 are arranged in the sliding rail 41 in a rolling manner, the driven sleeve 43 is arranged between the limiting wheels 42 in a rotating manner, the lifting rod 44 is arranged on the driven sleeve 43 in a sliding manner, and the operation handle 45 is arranged at the upper end of the lifting rod 44 in a rotating manner; the lifting rod 44 is more convenient to move left and right by operating the handle 45, and meanwhile, the limiting wheel 42 also rolls in the sliding rail 41.

The lower end of the lifting rod 44 is provided with a mounting middle plate 46, the upper end of the mounting middle plate 46 is symmetrically provided with a sliding side plate 47 with an L-shaped structure in a sliding fit mode, the lifting rod 44 can drive the mounting middle plate 46 and the sliding side plate 47 to move up and down together when moving up and down, and the lifting rod 44 can also drive the mounting middle plate 46 and the sliding side plate 47 to swing along the limiting wheel 42; the lower ends of the mounting middle plate 46 and the sliding side plate 47 are provided with sampling ends 48, and the sampling ends 48 can perform the operation of scraping and sampling the skin under the condition of being indirectly controlled by the lifting rod 44; the vertical hem of sliding side plate 47 upper end is provided with and supports and press spring rod 49 between, and the opposite side of sliding side plate 47 is in the laminating all the time adjusts wide board 30 under the elasticity effect of pressing spring rod 49, consequently just can adjust the width of sampling end 48 when adjusting the sampling area width, has improved the convenience of carrying out width adjustment to sampling end 48.

Referring to fig. 5, a sampling end 48, which is indirectly controlled by the lifter 44, and is used to scrape samples from the skin surface; specifically, the sampling end 48 includes a sampling scraper 480 and a sampling side plate 481, the sampling scraper 480 is detachably disposed at the lower end of the mounting middle plate 46, the lower ends of the sliding side plates 47 are respectively detachably provided with the sampling side plate 481 attached to the sampling scraper 480, and the lower ends of the sampling side plate 481 and the sampling scraper 480 are inclined to a side far away from the detection device; when the middle plate 46 and the sliding side plate 47 are controlled by the lifting rod 44, the sampling scraping plate 480 and the sampling side plate 481 can be controlled to move simultaneously, so that the sampling scraping plate 480 and the sampling side plate 481 can scrape a proper amount of lesion samples from the skin surface, and the sampling operation is realized; the sampling side plate 481 can also be adjusted together with the slide side plate 47, so that different use requirements can be met.

Embodiment two:

referring to fig. 6, in the technical solution disclosed in the first embodiment, it can be seen that the sampling scraper 480 and the sampling side plate 481 are easy to swing along the limiting wheel 42, so that after the sample scraped from the lesion area on the skin falls to the upper end of the extension plate 12, the sample is not easy to be scraped to the right by the sampling scraper 480 and the sampling side plate 481 to the upper end of the slide glass 10, and therefore, in order to facilitate scraping the sample to the upper end of the slide glass 10, the sample scraping unit 6 is provided on the basis of the first embodiment; specifically, the sample scraping unit 6 includes a slide plate 60, a scraping rod 61, an operation plate 62, a scraping plate 63, a slide scraper 64, a magnet block 65, and a return spring rod 66.

The sliding plates 60 with the 'king' -shaped structures are arranged between the sliding rails 41, the sliding plates 60 are provided with scraping rods 61 in a vertically sliding fit mode, the scraping rods 61 can only move up and down and cannot swing along the sliding plates 60, and the sliding plates 60 can move left and right between the sliding rails 41; the upper end of the scraping rod 61 is provided with an operation plate 62 positioned on the upper side of the sliding rail 41, and the scraping rod 61 is conveniently controlled through the operation plate 62; the lower end of the scraper bar 61 is provided with a scraper 63 for scraping the sample from the lower extension plate 12 to the upper end of the slide 10.

A sliding scraper 64 is arranged on one side of the scraper 63 close to the installation middle plate 46, the lower ends of the sliding scraper 64 and the scraper 63 are inclined towards one side close to the installation middle plate 46, magnet blocks 65 are arranged at the upper ends of the sliding scraper 64, and a reset compression spring rod 66 is arranged between the magnet blocks 65; the sliding scraper 64 and the magnet block 65 are always attached to the width adjusting plate 30 under the elastic action of the reset spring rod 66, and the sliding scraper 64 can be driven to be adjusted together when the distance between the width adjusting plates 30 is adjusted, so that the sliding scraper 64 can be always adapted to the distance between the width adjusting plates 30.

After the sampling end 48 scrapes part of the lesion tissue on the skin surface to the upper end of the extension plate 12, the lifting rod 44 drives the sampling end 48 to move upwards, then drives the scraping rod 61 to move upwards, so that the lower ends of the scraping plate 63 and the sliding scraping plate 64 are separated from the extension plate 12, and then drives the scraping plate 63 and the sliding scraping plate 64 to move leftwards through the scraping rod 61, so that the lower ends of the scraping plate 63 and the sliding scraping plate 64 can contact the triangular barrier strip 32, then drives the scraping plate 63 and the sliding scraping plate 64 to move downwards and attach to the extension plate 12 through the scraping rod 61, and then indirectly drives the scraping plate 63 and the sliding scraping plate 64 to move rightwards, so that a sample at the upper end of the extension plate 12 can be scraped to the upper end of the glass slide 10.

As can be seen from the above-disclosed technical solution, referring to fig. 6 and 7, when the sliding scraper 64 moves rightward without contacting the width adjustment plate 30, the sliding scraper 64 moves to a side far from the scraper 63 by the elastic action of the reset spring rod 66, so that the moving sliding scraper 64 is difficult to move leftward between the width adjustment plates 30, and thus, in order to avoid this, a limiting unit 7 for continuously blocking the sliding scraper 64 is provided, in particular; the limiting unit 7 comprises a storage groove 70, a limiting sliding plate 71 and a magnetic attraction block 72, wherein the storage groove 70 positioned at the corner is formed in one side, close to the detection device, of the width adjusting plate 30, the limiting sliding plate 71 is arranged in the storage groove 70 in a sliding mode, and the magnetic attraction block 72 which penetrates through the storage groove 70 and corresponds to the magnet block 65 is arranged on the limiting sliding plate 71.

When the sliding scraper 64 moves rightwards, the magnet block 65 can drive the magnet block 72 and the limiting slide plate 71 to move rightwards together, so that the limiting slide plate 71 continuously limits the sliding scraper 64 separated from the width adjusting plate 30, the situation can be avoided, when the sliding scraper 64 moves leftwards and resets, the magnet block 65 can drive the magnet block 72 to move leftwards together in a magnetic attraction mode, the magnet block 72 can also drive the limiting slide plate 71 to move leftwards into the accommodating groove 70, and then, when the magnet block 65 continues to move leftwards, the magnet block can be separated from the magnet block 72, further sample scraping operation can be performed, and the magnet block 72 can not interfere with the moving track of the magnet block 65.

Embodiment III:

referring to fig. 8, in order to avoid interference of the cover glass 11 with the moving track of the scraping bar 61, a blade unit 2 is provided which can drive the cover glass 11 to move up and down and left and right on the basis of the second embodiment; specifically, the support piece unit 2 comprises a sliding through groove 20, a driven sliding block 21, a lifting push rod 22, a fixer 23, a glass clamping strip 24, a glass clamping lower strip 25 and a locking insert block 26, wherein the sliding through groove 20 is symmetrically formed in the upper end of the shell 1, the driven sliding block 21 is arranged in the sliding through groove 20 in a sliding manner, the lifting push rod 22 is vertically arranged on the driven sliding block 21 in a sliding manner in a penetrating manner, and the driven sliding block 21 can be driven to slide left and right in the sliding through groove 20 through the lifting push rod 22.

The lifting push rod 22 is provided with a fixer 23, and the fixer 23 can fix the lifting support rod so that the lifting support rod cannot slide up and down; the lower end of the lifting push rod 22 passes through the driven slide block 21 and is provided with a glass clamping strip 24 connected with the cover glass 11, and when the lifting push rod 22 moves up and down or left and right, the cover glass 11 can be driven to move together through the glass clamping strip 24; when the scraping rod 61 drives the sliding plate 60 to move rightward along the sliding rail 41, the slide glass 10 drives the glass clamping bar 24, the lifting push rod 22 and the driven slide block 21 to move rightward together under the pushing of the sliding plate 60, so that the moving track of the scraping rod 61 is not interfered.

The lower end face of the glass clamping strip 24 is of a zigzag structure, two sides of the glass slide 10 are provided with glass clamping lower strips 25 which are matched with the glass clamping strip 24 in a concave-convex manner, and when the lower ends of the glass clamping strips 24 are attached to the upper ends of the glass clamping lower strips, the glass clamping strips 24 are driven to drive the glass clamping lower strips to move together; the right side of the glass clamping lower strip 25 is provided with a clamping groove, and a locking insert block 26 positioned in the clamping groove is arranged on the shell 1 in a sliding way, so that the locking insert block 26 can fix the glass clamping lower strip 25 and the glass slide 10.

When the cover glass 11 needs to be moved downwards to the upper end of the glass slide 10, the cover glass 11 is driven to move leftwards and reset through the lifting push rod 22, then the lifting push rod 22 is not fixed through the fixer 23, then the cover glass 11 is indirectly driven to move downwards through the lifting push rod 22 and cover a sample at the upper end of the glass slide 10, at the moment, the glass clamping strip 24 and the saw-tooth structure on the clamping lower strip can be matched in a concave-convex manner, then the locking insert block 26 is pulled outwards, the clamping lower strip and the glass slide 10 are not fixed any more, and finally the glass slide 10 and the cover glass 11 can be driven to move rightwards to the lower end of the detection unit 5 through the lifting push rod 22.

With continued reference to FIG. 8, the retainer 23 in this application; specifically, the fixer 23 includes a rod sleeve block 230, a plug block 231 and a linkage bar 232, the rod sleeve block 230 is slidably disposed at the upper end of the housing 1 and is connected with the driven slider 21, a plug slot is formed at the lower side of the lifting push rod 22, and the plug block 231 located in the corresponding plug slot is slidably disposed on the rod sleeve block 230; so that the lifting push rod 22 can not slide up and down any more, the cover glass 11 can be fixed on the upper side of the inside of the shell 1, a sample scraped from the skin can not fall to the upper end of the cover glass 11, and when the cover glass 11 needs to be driven to move up and down, the plug-in block 231 can be taken out from the plug-in through groove; a linkage bar 232 is also arranged between the upper ends of the lifting push rods 22, and the lifting push rods 22 on the front side and the rear side are conveniently driven to move together through the linkage bar 232.

As can be seen from the above-disclosed technical solution, as shown in fig. 9, before the sample is observed and detected, most of the areas of the slide 10 and the cover glass 11 need to be moved rightward and separated from the housing 1, but the slide 10 and the cover glass 11 located outside the housing 1 are not supported, so that the slide 10 and the cover glass 11 are easily vibrated up and down, thereby affecting the observation and detection effect of the detection unit 5 on the sample, and in order to avoid such a problem, a folded slide supporting unit 8 for supporting the slide 10 is provided.

Specifically, the folding support sheet unit 8 includes a support glass strip 80, a support groove 81, a connecting rod 82 and a -shaped insert 83, the support glass strip 80 is symmetrically arranged at one side of the lower end of the housing 1 far away from the extension plate 12 through a hinge, the support groove 81 is arranged at the opposite side of the upper end of the support glass strip 80, when the glass slide 10 moves rightwards, the support groove 81 slides at the upper end of the support groove 81, at this time, the support groove 81 can limit and guide the moving track of the glass slide 10, and the support glass strip 80 can support the glass slide 10 and the clamping lower strip, so that the problems are avoided; when not in use, the glass supporting strips 80 can be turned downwards to be folded so as to save space.

In order to facilitate the two glass supporting strips 80 to turn right together at the same time, a connecting rod 82 is arranged between the glass supporting strips 80 to improve the convenience of turning the glass supporting strips 80; in order to enable the unfolded glass supporting strip 80 to stably support the glass slide 10, an inserting groove is formed in the shell 1, -shaped inserting blocks 83 and -shaped inserting blocks 83 are slidably arranged on the glass supporting strip 80, and the upper ends of the -shaped inserting blocks 83 are positioned in the inserting groove, so that the function of fixing the unfolded glass supporting strip is realized, and the supporting effect of the glass supporting strip 80 is improved; before the glass supporting strip 80 is folded, the -shaped plug 83 is required to be pulled out so as to not fix the glass supporting strip 80.

Referring to fig. 10, in the process of using the mechanism from the skin surface, there is a possibility that the scraped material from the skin surface will fly out from the opening on the right side of the housing 1, and in order to avoid this, a blocking unit 9 is provided at the opening on the right side of the housing 1; specifically, the plugging unit 9 includes a side baffle 90 and a glass through groove 91, the side baffle 90 is vertically disposed on the housing 1 at an opening at one end far away from the extension plate 12, and the side baffle 90 can plug the opening at the right end of the housing 1 to prevent the sample from drifting outwards.

The side baffle 90 is provided with a glass passing groove 91 corresponding to the cover glass 11 and the glass clamping strip 24, when the cover glass 11 and the glass clamping strip 24 are driven to move rightwards by the indirect drive of the lifting push rod 22, the cover glass 11 and the glass clamping strip 24 can move rightwards into the glass passing groove 91, so that the side baffle 90 cannot interfere the moving process of the cover glass 11; the distance between the side shutter 90 and the inner wall of the lower side of the housing 1 corresponds to the thicknesses of the slide glass 10 and the cover glass 11, so that the slide glass 10 and the cover glass 11 attached to each other can slide right and left while filling the lower side of the side shutter 90.

Referring to fig. 11, a detection unit 5 in the present application; specifically, the detecting unit 5 includes a supporting frame 50, a rectangular frame 51, an adjusting slide plate 52 and a detector 53, the supporting frame 50 with a -shaped structure is arranged at the upper end of the right side of the side baffle 90, the rectangular frame 51 is arranged at the inner side of the supporting frame 50 in a left-right sliding fit manner, the adjusting slide plate 52 is arranged at the inner side of the rectangular frame 51 in a front-back sliding fit manner, and the detector 53 for observation and detection is arranged on the adjusting slide plate 52; the detector 53 can observe and detect samples positioned on the lower side of the detector, and the detector 53 can observe and detect samples at different positions by adjusting the matching of the sliding plate 52 and the rectangular frame 51, so that the use range of the detector 53 is improved.

When in operation, the device comprises: firstly, the adjusting unit 3 is adjusted according to the pathological change area on the skin surface of a human body, so that the opening at the left end of the shell 1 can correspond to the pathological change area on the skin surface, then the left end of the shell 1 is sleeved on the outer side of the pathological change area on the skin, and then the pathological change area on the skin is scraped and sampled by the sampling unit 4.

And a second step of: after the sampling end 48 scrapes part of the lesion tissue on the skin surface to the upper end of the extension plate 12, the lifting rod 44 drives the sampling end 48 to move upwards, then drives the scraping rod 61 to move upwards, so that the lower ends of the scraping plate 63 and the sliding scraping plate 64 are separated from the extension plate 12, and then drives the scraping plate 63 and the sliding scraping plate 64 to move leftwards through the scraping rod 61, so that the lower ends of the scraping plate 63 and the sliding scraping plate 64 can contact the triangular barrier strip 32, then drives the scraping plate 63 and the sliding scraping plate 64 to move downwards and attach to the extension plate 12 through the scraping rod 61, and then indirectly drives the scraping plate 63 and the sliding scraping plate 64 to move rightwards, so that a sample at the upper end of the extension plate 12 can be scraped to the upper end of the glass slide 10.

And a third step of: the cover glass 11 is driven to move leftwards to reset through the lifting push rod 22, then the lifting push rod 22 is not fixed through the fixing device 23, then the cover glass 11 is indirectly driven to move downwards through the lifting push rod 22 and cover a sample at the upper end of the glass slide 10, at the moment, the saw-tooth structure on the glass clamping strip 24 and the clamping lower strip can be matched with each other in a concave-convex mode, then the locking insert block 26 is pulled outwards, the clamping lower strip and the glass slide 10 are not fixed, finally the glass slide 10 and the cover glass 11 can be driven to move rightwards to the lower end of the detection unit 5 through the lifting push rod 22, and at the moment, the folding support piece unit 8 plays a role in supporting the glass slide 10.

Fourth step: the detector 53 is adapted to observe and detect samples at different positions by adjusting the slide 52 and the rectangular frame 51.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.

Claims (9)

1. A gene tissue sample sampling detection system, comprising a shell (1), characterized in that: the casing (1) be inside cavity both ends open-ended rectangle structure, glass carrier groove has been seted up to casing (1) inside lower extreme, be provided with slide glass (10) in the glass carrier groove, casing (1) upper end is provided with holds in the palm piece unit (2), be provided with coverslip (11) on holding in the palm piece unit (2), one side opening part of casing (1) bilateral symmetry is provided with rather than integrated into one piece's extension board (12), be provided with width adjusting unit (3) between extension board (12), still be provided with sampling unit (4) that are located width adjusting unit (3) inboard on extension board (12), one side that extension board (12) was kept away from to casing (1) is provided with detection unit (5) that are used for detecting, wherein:

the sampling unit (4) comprises a sliding through groove (40) formed in the upper end of the shell (1) and a sliding rail (41) arranged on the sliding through groove (40), limiting wheels (42) are arranged in the sliding rail (41) in a rolling mode, a driven sleeve (43) is rotatably arranged between the limiting wheels (42), a lifting rod (44) is arranged on the driven sleeve (43) in a sliding mode in a penetrating mode, an operation handle (45) is rotatably arranged at the upper end of the lifting rod (44), an installation middle plate (46) is arranged at the lower end of the lifting rod (44), sliding side plates (47) of an L-shaped structure are symmetrically arranged at the upper end of the installation middle plate (46) in a sliding mode, sampling ends (48) are arranged at the lower ends of the installation middle plate (46) and the sliding side plates (47), and a pressing spring rod (49) is arranged between vertical folds at the upper end of the sliding side plates (47);

still including setting up in the track (41) that slides, and be used for being used for with sample after sampling of sampling end (48) to slide glass (10) on sample scraping unit (6), sample scraping unit (6) including slide plate (60), scraper bar (61), operating panel (62), scraper plate (63), slide scraper (64), magnetite piece (65) and reset pressure spring pole (66), slide plate (60) of "king" style of calligraphy structure set up between slide track (41), be provided with scraper bar (61) on slide plate (60) through upper and lower sliding fit's mode, scraper bar (61) upper end is provided with operating panel (62) that are located slide track (41) upside, scraper bar (61) lower extreme is installed scraper bar (63), one side that is close to installation medium plate (46) on scraper bar (63) is provided with slide scraper plate (64), slide scraper plate (64) and scraper bar (63) lower extreme all incline to one side that is close to installation medium plate (46), slide scraper plate (64) upper end all is provided with magnetite piece (65), reset between pressure spring piece (66).

2. The system for sampling and testing a tissue sample according to claim 1, wherein: the sampling end (48) comprises a sampling scraping plate (480) and a sampling side plate (481), the sampling scraping plate (480) is arranged at the lower end of the installation middle plate (46) in a detachable mode, the lower end of the sliding side plate (47) is provided with the sampling side plate (481) attached to the sampling scraping plate (480) in a detachable mode, and the lower ends of the sampling side plate (481) and the sampling scraping plate (480) incline to one side far away from the detection device.

3. The system for sampling and testing a tissue sample according to claim 1, wherein: width adjusting unit (3) including width adjusting board (30), spacing arch (31), triangle blend stop (32), limiting plate (33), support tight bolt (34) and rotating block (35), L shape structure's width adjusting board (30) set up perpendicularly in the inside one side that is close to extension board (12) of casing (1) through sliding fit's mode symmetry, width adjusting board (30) are provided with spacing arch (31) in the upper and lower both ends symmetry of opposite side, extension board (12) upper end of downside is provided with triangle blend stop (32) laminating mutually with width adjusting board (30) left end, still be provided with between the upper and lower lateral wall of casing (1) and be used for carrying out spacing limiting plate (33) to width adjusting board (30), casing (1) upper end wears to be equipped with through screw fit's mode and is used for supporting tight bolt (34) that spacing to width adjusting board (30), support tight bolt (34) lateral surface top cover is equipped with rotating block (35) that are located casing (1) upper end.

4. A system for sampling and testing a tissue specimen according to claim 3, further comprising a limiting unit (7) for facilitating the movement and resetting of the scraping unit (6) to a side close to the sampling unit (4), characterized in that: the limiting unit (7) comprises a storage groove (70), a limiting sliding plate (71) and a magnetic attraction block (72), wherein the storage groove (70) positioned at the corner is formed in one side, close to the detection device, of the width adjusting plate (30), the limiting sliding plate (71) is arranged in the storage groove (70), and the magnetic attraction block (72) penetrating through the storage groove (70) and corresponding to the magnetic block (65) is arranged on the limiting sliding plate (71).

5. The system for sampling and testing a tissue sample according to claim 1, wherein: the glass holding unit (2) comprises a sliding through groove (20), a driven sliding block (21), a lifting push rod (22), a fixer (23), a glass clamping strip (24), glass clamping lower strips (25) and locking inserting blocks (26), wherein the sliding through groove (20) is symmetrically formed in the upper end of the shell (1), the driven sliding block (21) is arranged in the sliding through groove (20) in a sliding mode, the lifting push rod (22) is vertically arranged on the driven sliding block (21) in a sliding mode, the fixer (23) is arranged on the lifting push rod (22), the lower end of the lifting push rod (22) penetrates through the driven sliding block (21) and is provided with the glass clamping strip (24) connected with the cover glass (11), the lower end face of the glass clamping strip (24) is of a zigzag structure, clamping lower strips (25) which are in concave-convex fit with the glass clamping strip (24) are arranged on two sides of the glass clamping lower strips (10), clamping grooves are formed in the right side of the glass clamping lower strips (25), and the locking inserting blocks (26) which are arranged in the clamping grooves in the sliding mode.

6. The system for sampling and testing a tissue sample according to claim 5, wherein: the fixer (23) comprises a plug rod sleeve block (230), a plug block (231) and a linkage bar (232), wherein the plug rod sleeve block (230) is arranged at the upper end of the shell (1) in a sliding manner and is connected with the driven sliding block (21), a plug-in groove is formed in the lower side of the lifting push rod (22), the plug rod sleeve block (230) is provided with the plug block (231) in the plug-in groove in a sliding manner, and the linkage bar (232) is arranged between the upper ends of the lifting push rod (22).

7. A system for sampling and testing a tissue specimen according to claim 1, further comprising a folding blade unit (8) for holding a slide (10) sliding out of the housing (1), characterized in that: folding support piece unit (8) include support glass strip (80), bearing groove (81), connecting rod (82) and shape inserted block (83), support glass strip (80) set up one side of keeping away from extension board (12) at casing (1) lower extreme through the hinge symmetry, support glass strip (80) upper end's opposite side has been seted up bearing groove (81), and support glass strip (80) between be provided with connecting rod (82), set up grafting recess on casing (1), slide on support glass strip (80) and be provided with shape inserted block (83), shape inserted block (83) upper end is located grafting recess.

8. The system for sampling and testing a tissue sample according to claim 5, further comprising a plugging unit (9) for plugging the right opening of the housing (1), wherein: the plugging unit (9) comprises a side baffle (90) and a glass passing groove (91), wherein the side baffle (90) is vertically arranged at an opening at one end of the shell (1) far away from the extension plate (12), the side baffle (90) is provided with the glass passing groove (91) corresponding to the cover glass (11) and the glass clamping strip (24), and the distance between the side baffle (90) and the inner wall of the lower side of the shell (1) corresponds to the thickness of the glass slide (10) and the glass cover glass (11).

9. The system for sampling and testing a tissue sample according to claim 8, wherein: the detecting unit (5) comprises a supporting frame (50), a rectangular frame (51), an adjusting slide plate (52) and a detector (53), wherein the supporting frame (50) with a -shaped structure is arranged at the upper end of the right side of the side baffle (90), the rectangular frame (51) is slidably arranged on the inner side of the supporting frame (50), the adjusting slide plate (52) is slidably arranged on the inner side of the rectangular frame (51), and the detector (53) for observing and detecting is arranged on the adjusting slide plate (52).