CN116194755A - 隧道纳米管细胞及其用于递送生物分子的方法 - Google Patents

隧道纳米管细胞及其用于递送生物分子的方法 Download PDF

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CN116194755A
CN116194755A CN202180051764.1A CN202180051764A CN116194755A CN 116194755 A CN116194755 A CN 116194755A CN 202180051764 A CN202180051764 A CN 202180051764A CN 116194755 A CN116194755 A CN 116194755A
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cell
cells
tnt
crispr
genome editing
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J·K·乔昂格
P·卡贝塞拉斯
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General Hospital Corp
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0603—Embryonic cells ; Embryoid bodies
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0687—Renal stem cells; Renal progenitors
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
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    • C12N2510/00—Genetically modified cells

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  • Gastroenterology & Hepatology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN202180051764.1A 2020-06-23 2021-06-23 隧道纳米管细胞及其用于递送生物分子的方法 Withdrawn CN116194755A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063042909P 2020-06-23 2020-06-23
US63/042,909 2020-06-23
PCT/US2021/038588 WO2021262788A2 (en) 2020-06-23 2021-06-23 Tunneling nanotube cells and methods of use thereof for delivery of biomolecules

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CN116194755A true CN116194755A (zh) 2023-05-30

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US (1) US20220002718A1 (enExample)
EP (1) EP4168560A4 (enExample)
JP (1) JP2023531506A (enExample)
CN (1) CN116194755A (enExample)
AU (1) AU2021296822A1 (enExample)
CA (1) CA3187571A1 (enExample)
WO (1) WO2021262788A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114258398A (zh) 2019-06-13 2022-03-29 总医院公司 工程化的人内源性病毒样颗粒及使用其递送至细胞的方法
CN116670154A (zh) 2020-07-24 2023-08-29 总医院公司 增强的病毒样颗粒及使用其递送至细胞的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107635569A (zh) * 2015-04-30 2018-01-26 南加利福尼亚大学 分泌型tnt car细胞免疫疗法
US20190008896A1 (en) * 2017-07-07 2019-01-10 Richard Postrel Methods and Systems for the Prevention, Treatment and Management of Disease and Effects of Aging Via Cell-to-Cell Restoration Therapy Using Subcellular Transactions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013151663A1 (en) * 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107635569A (zh) * 2015-04-30 2018-01-26 南加利福尼亚大学 分泌型tnt car细胞免疫疗法
US20190008896A1 (en) * 2017-07-07 2019-01-10 Richard Postrel Methods and Systems for the Prevention, Treatment and Management of Disease and Effects of Aging Via Cell-to-Cell Restoration Therapy Using Subcellular Transactions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHRISTIAN SCHILLER等: "LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation", 《JOURNAL OF CELL SCIENCE》, vol. 126, no. 3, 28 February 2013 (2013-02-28), pages 769 *
CHRISTIAN SCHILLER等: "Tunneling nanotubes enable intercellular transfer of MHC class I molecules", 《HUMAN IMMUNOLOGY》, vol. 74, 7 December 2012 (2012-12-07), pages 3 *
KOJI HASE等: "M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex", 《NATURE CELL BIOLOGY》, vol. 11, no. 12, 22 November 2009 (2009-11-22), pages 1 - 18 *
MICHAEL RENTELN等: "A synthetic mitochondrial-based vector for therapeutic purposes", 《MEDICAL HYPOTHESES》, vol. 117, 31 August 2018 (2018-08-31), pages 2 - 4 *
王晓晴等: "隧道纳米管形成的促进机制研究进展", 《第二军医大学学报》, vol. 36, no. 11, 16 December 2015 (2015-12-16), pages 1229 - 1232 *

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AU2021296822A1 (en) 2023-02-02
EP4168560A4 (en) 2024-07-24
WO2021262788A3 (en) 2022-02-03
WO2021262788A2 (en) 2021-12-30
EP4168560A2 (en) 2023-04-26
US20220002718A1 (en) 2022-01-06
CA3187571A1 (en) 2021-12-30
JP2023531506A (ja) 2023-07-24

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