CN116158765A - Electrophysiological signal compensation system and compensation method - Google Patents

Electrophysiological signal compensation system and compensation method Download PDF

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Publication number
CN116158765A
CN116158765A CN202111416307.6A CN202111416307A CN116158765A CN 116158765 A CN116158765 A CN 116158765A CN 202111416307 A CN202111416307 A CN 202111416307A CN 116158765 A CN116158765 A CN 116158765A
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signal
compensation
electrophysiological
processing system
original
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杨良滔
张翊
吴景龙
周杰
刘青
刘新
郑海荣
梁栋
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Priority to CN202111416307.6A priority Critical patent/CN116158765A/en
Priority to PCT/CN2021/133749 priority patent/WO2023092516A1/en
Publication of CN116158765A publication Critical patent/CN116158765A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0223Operational features of calibration, e.g. protocols for calibrating sensors

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
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  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

The application relates to an electrophysiological signal compensation system and a compensation method. The electrophysiological signal compensation system comprises a working electrode, an impedance test system, a signal compensation system and a signal processing system; the working electrode is attached to the skin surface of the patient and is used for collecting the original electrophysiological signals of the patient and transmitting the original electrophysiological signals to the signal processing system; the impedance test system is used for collecting internal resistance data of the working electrode and transmitting the resistance data to the signal compensation system; the signal compensation system is used for calculating a signal to be compensated according to the resistance data and transmitting the compensation signal to the signal processing system; the signal processing system is used for adding the original electrophysiological signal and the compensation signal to obtain a compensated electrophysiological signal. According to the embodiment of the application, after the signal to be compensated is calculated through the signal compensation system, the original electrophysiological signal and the compensation signal are added through the signal processing system, so that the compensated electrophysiological signal is obtained, and the signal quality is greatly improved.

Description

Electrophysiological signal compensation system and compensation method
Technical Field
The application belongs to the technical field of physiological signal processing, and particularly relates to an electrophysiological signal compensation system and a compensation method.
Background
Electrophysiological signals are one of the most important physiological signals, can help to study physiological states, are applied to disease diagnosis and treatment, and can be also applied to the emerging fields of artificial intelligence such as brain-computer interfaces. Electrophysiological signals are caused by differences in ion concentration inside and outside the cell membrane. In a stationary state of the living body, a stationary potential is generated, and when an action occurs, an action potential is generated. Each potential is generated in relation to the physiological state and behaviour of the person. Therefore, it is important to accurately, real-time and efficiently detect electrophysiological signals.
Common electrophysiological signal detection techniques include electrocardiography, myoelectricity, electroencephalogram, and the like. The electrocardiogram can help the group doctor to know the beating condition of the heart. Electromyography is caused by muscle contraction and can help the disabled person to recover part/all of the activity. Electroencephalogram is useful for diagnosis and treatment of brain diseases, such as neurodegenerative diseases like Alzheimer's disease, parkinson's disease, etc.
In the prior art, a common electric signal acquisition system comprises electrodes, a signal amplifier, a converter, a signal processor, a display and the like. The electrode is used for acquiring the physiological signals, is an important core component, and has an important position. However, during the service of the electrode, the contact impedance is changed in real time, so that the electric signal can change with time, and the signal quality is greatly reduced.
Disclosure of Invention
The present application provides an electrophysiological signal compensation system and a compensation method, which aim to solve at least one of the above technical problems in the prior art to a certain extent.
In order to solve the above problems, the present application provides the following technical solutions:
an electrophysiological signal compensation system comprises a working electrode, an impedance test system, a signal compensation system and a signal processing system; the working electrode, the impedance testing system, the signal compensation system and the signal processing system are connected in sequence;
the working electrode is attached to the skin surface of a patient and is used for collecting an original electrophysiological signal of the patient and transmitting the original electrophysiological signal to the signal processing system;
the impedance test system is used for collecting internal resistance data of the working electrode and transmitting the resistance data to the signal compensation system;
the signal compensation system is used for calculating a signal to be compensated according to the resistance data and transmitting the compensation signal to the signal processing system;
the signal processing system is used for adding the original electrophysiological signal and the compensation signal to obtain the compensated electrophysiological signal.
The technical scheme adopted by the embodiment of the application further comprises a reference electrode, wherein the reference electrode and the working electrode are respectively connected with the signal processing system, the reference electrode is used for conducting a circuit and forming a voltage difference, and a loop system is formed by the reference electrode, the working electrode and the signal processing system.
The technical scheme adopted by the embodiment of the application further comprises: the signal compensation system calculates a signal to be compensated according to the resistance data, specifically:
the signal compensation system calculates a signal to be compensated by using an ohmic algorithm based on the resistance data; the compensation signal calculation formula is: u=ir; wherein U is compensation voltage, I is monitoring current, and R is resistance data.
The technical scheme adopted by the embodiment of the application further comprises: the signal processing system adds the original electrophysiological signal and the compensation signal to be:
the signal processing system adds the original electrophysiological signal and the compensation signal through addition operation to obtain the compensated electrophysiological signal.
The technical scheme adopted by the embodiment of the application further comprises: the impedance test system is an alternating current impedance test system or a direct current resistance analysis system.
The technical scheme adopted by the embodiment of the application further comprises: the original electrophysiological signal comprises an electroencephalogram signal, an electromyographic signal or an electrocardiosignal.
The embodiment of the application adopts another technical scheme that: an electrophysiological signal compensation method, comprising:
collecting an original electrophysiological signal of a patient through a working electrode, and transmitting the original electrophysiological signal to a signal processing system;
acquiring internal resistance data of a working electrode through an impedance test system, and transmitting the resistance data to a signal compensation system;
calculating a signal to be compensated according to the resistance data through a signal compensation system, and transmitting the compensation signal to a signal processing system;
and adding the original electrophysiological signal and the compensation signal through the signal processing system to obtain the compensated electrophysiological signal.
Compared with the prior art, the beneficial effect that this application embodiment produced lies in: according to the electrophysiological signal compensation system and the electrophysiological signal compensation method, the original electrophysiological signal is collected through the electrode, the resistance change is monitored through the impedance test system, the resistance data is transmitted to the signal compensation system, after the signal to be compensated is calculated through the signal compensation system, the original electrophysiological signal and the compensation signal are added through the signal processing system, and the compensated electrophysiological signal is obtained, so that the signal quality is greatly improved.
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FIG. 1 is a schematic diagram of an electrophysiological signal compensation system of an embodiment of the present application;
fig. 2 is a flowchart of an electrophysiological signal compensation method according to an embodiment of the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.
Aiming at the defects of the prior art, the electrophysiological signal compensation system in the embodiment of the application acquires an original electrophysiological signal through the electrode, monitors resistance change through the impedance test system connected with the electrode, transmits resistance data to the signal compensation system, and compensates the compensation signal to the original electrophysiological signal after calculating a signal to be compensated through the signal compensation system to obtain a brand-new electrophysiological signal so as to greatly improve signal quality.
Specifically, please refer to fig. 1, which is a schematic diagram illustrating a structure of an electrophysiological signal compensation system according to an embodiment of the present application. The electrophysiological signal compensation system of the embodiment of the application comprises a reference electrode 1, a working electrode 2, an impedance testing system 3, a signal compensation system 4 and a signal processing system 5. The reference electrode 1 and the working electrode 2 are respectively connected with the signal processing system 5, the reference electrode 1 is used for conducting a circuit and forming a voltage difference, the working electrode 2 is used for receiving charges and electrophysiological signals, and a loop system is formed by the reference electrode 1, the working electrode 2 and the signal processing system 5. The working electrode 2, the impedance testing system 3, the signal compensation system 4 and the signal processing system 5 are connected in sequence. The working electrode 2 is attached to the skin surface of the patient, the raw electrophysiological signal is acquired according to the generated contact impedance, and the raw electrophysiological signal is transmitted to the signal processing system 5. The impedance test system 3 is used for collecting internal resistance data (internal resistance) of the working electrode 2 in real time, transmitting the resistance data to the signal compensation system 4, calculating a signal to be compensated by using an ohmic algorithm based on the resistance data by the signal compensation system 4, and transmitting the compensation signal to the signal processing system 5; the signal processing system 5 adds the original electrophysiological signal and the compensation signal by an addition operation to obtain a compensated electrophysiological signal.
In the embodiment of the present application, the calculation formula for calculating the compensation signal by the signal compensation system 4 is as follows: u=ir; where U is the compensation voltage, I is the monitor current, and R is the internal resistance data of the working electrode 2.
In the present embodiment, the impedance test system 3 includes, but is not limited to, an ac impedance test system or a dc resistance analysis system.
The electrophysiological signal compensation system of the embodiment of the application can be applied to various electrophysiological detection systems such as mobile type, fixed type and wearable type, and is suitable for compensation of various electrophysiological signals such as electroencephalogram, myoelectricity and electrocardio.
Based on the above, the electrophysiological signal compensation system of the embodiment of the application collects the original electrophysiological signal through the electrode, monitors the resistance change through the impedance test system, transmits the resistance data to the signal compensation system, and adds the original electrophysiological signal and the compensation signal through the signal processing system after calculating the signal to be compensated through the signal compensation system, thereby obtaining the compensated electrophysiological signal, and greatly improving the signal quality.
Referring to fig. 2, a flowchart of an electrophysiological signal compensation method according to an embodiment of the present application is shown. The electrophysiological signal compensation method of the embodiment of the application comprises the following steps:
s1: attaching a working electrode to the skin surface of a patient, collecting an original electrophysiological signal of the patient by the working electrode according to the generated contact impedance, and transmitting the original electrophysiological signal to a signal processing system;
s2: acquiring internal resistance data of the working electrode in real time through an impedance test system, and transmitting the resistance data to a signal compensation system;
s3: calculating a signal to be compensated by using an ohmic algorithm based on the resistance data through a signal compensation system, and transmitting the compensation signal to a signal processing system;
s4: the original electrophysiological signal and the compensation signal are added by the signal processing system through addition operation, so that the compensated electrophysiological signal is obtained.
Based on the above, the electrophysiological signal compensation method in the embodiment of the application collects the original electrophysiological signal through the electrode, monitors the resistance change through the impedance test system, transmits the resistance data to the signal compensation system, calculates the signal to be compensated through the signal compensation system, and adds the original electrophysiological signal and the compensation signal through the signal processing system to obtain the compensated electrophysiological signal, thereby greatly improving the signal quality.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (7)

1. An electrophysiological signal compensation system is characterized by comprising a working electrode, an impedance test system, a signal compensation system and a signal processing system; the working electrode, the impedance testing system, the signal compensation system and the signal processing system are connected in sequence;
the working electrode is attached to the skin surface of a patient and is used for collecting an original electrophysiological signal of the patient and transmitting the original electrophysiological signal to the signal processing system;
the impedance test system is used for collecting internal resistance data of the working electrode and transmitting the resistance data to the signal compensation system;
the signal compensation system is used for calculating a signal to be compensated according to the resistance data and transmitting the compensation signal to the signal processing system;
the signal processing system is used for adding the original electrophysiological signal and the compensation signal to obtain the compensated electrophysiological signal.
2. The electrophysiological signal compensation system of claim 1, further comprising a reference electrode for conducting a circuit and forming a voltage difference, the reference electrode and the working electrode being respectively connected to the signal processing system, the loop system being formed by the reference electrode, the working electrode and the signal processing system.
3. Electrophysiological signal compensation system according to claim 1 or 2, characterized in that the signal compensation system calculates the signal to be compensated from the resistance data in particular as:
the signal compensation system calculates a signal to be compensated by using an ohmic algorithm based on the resistance data; the compensation signal calculation formula is: u=ir; wherein U is compensation voltage, I is monitoring current, and R is resistance data.
4. The electrophysiological signal compensation system of claim 3, wherein the signal processing system adds the original electrophysiological signal and the compensation signal to:
the signal processing system adds the original electrophysiological signal and the compensation signal through addition operation to obtain the compensated electrophysiological signal.
5. The electrophysiological signal compensation system of claim 1, wherein the impedance testing system is an ac impedance testing system or a dc resistance analysis system.
6. The electrophysiological signal compensation system of claim 1, wherein the raw electrophysiological signal includes, but is not limited to, an electroencephalogram signal, an electromyographic signal, or an electrocardiographic signal.
7. A method of electrophysiological signal compensation, comprising:
collecting an original electrophysiological signal of a patient through a working electrode, and transmitting the original electrophysiological signal to a signal processing system;
acquiring internal resistance data of a working electrode through an impedance test system, and transmitting the resistance data to a signal compensation system;
calculating a signal to be compensated according to the resistance data through a signal compensation system, and transmitting the compensation signal to a signal processing system;
and adding the original electrophysiological signal and the compensation signal through the signal processing system to obtain the compensated electrophysiological signal.
CN202111416307.6A 2021-11-25 2021-11-25 Electrophysiological signal compensation system and compensation method Pending CN116158765A (en)

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CN202111416307.6A CN116158765A (en) 2021-11-25 2021-11-25 Electrophysiological signal compensation system and compensation method
PCT/CN2021/133749 WO2023092516A1 (en) 2021-11-25 2021-11-27 Electrophysiological signal compensation system and compensation method

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US6496721B1 (en) * 2000-04-28 2002-12-17 Cardiac Pacemakers, Inc. Automatic input impedance balancing for electrocardiogram (ECG) sensing applications
CN100423688C (en) * 2005-10-19 2008-10-08 深圳迈瑞生物医疗电子股份有限公司 Method and apparatus for inhibiting power frequency common-mode interference
US9591981B2 (en) * 2012-12-04 2017-03-14 Biosense Webster (Isreal) Ltd. Multi-channel ECG measurement
DE102015202447A1 (en) * 2015-02-11 2016-08-11 Siemens Healthcare Gmbh Suppression of the common-mode signal component in the measurement of bioelectric signals
CN110974210B (en) * 2019-12-09 2022-05-20 武汉联影智融医疗科技有限公司 Impedance correction method and device for physiological signal acquisition channel
TW202127027A (en) * 2019-12-31 2021-07-16 財團法人工業技術研究院 Physiological signal sensing and compensation system

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