CN116138842A

CN116138842A - Thrombolysis device

Info

Publication number: CN116138842A
Application number: CN202310108549.1A
Authority: CN
Inventors: 陈文俊; 刘鹏; 唐玉华; 李文锋
Original assignee: Shenzhen Baite Micro Medical Technology Co ltd
Current assignee: Shenzhen Baite Micro Medical Technology Co ltd
Priority date: 2022-07-19
Filing date: 2022-07-19
Publication date: 2023-05-23
Also published as: CN115068064A; CN115068064B

Abstract

The invention relates to a thrombus taking device, which comprises a thrombus taking bracket, wherein the thrombus taking bracket comprises an interception net and a plurality of interception members arranged on the interception net at intervals along the circumferential direction of the interception net, the proximal end of each interception member is connected with the interception net, and the distal end is a free end; the plurality of interception members are positioned outside the interception net in a natural state, each interception member is outwards turned from one end connected with the interception net, and in a stretching state, the outwards turned part can be distally turned; alternatively, in a natural state, the plurality of interceptors are located inside the interceptor web, and in a stretched state, the plurality of interceptors do not intersect in a radial direction. The thrombus taking device is favorable for improving the single thrombus taking amount.

Description

Thrombolysis device

Technical Field

The invention relates to the technical field of interventional medical instruments, in particular to a thrombus taking device.

Background

This section provides merely background information related to the present disclosure and is not necessarily prior art.

Pulmonary arterial embolism (pulmonary embolism, PE) refers to the clinical and pathophysiological syndrome in which an endogenous or exogenous embolic occludes a pulmonary artery or its branches causing pulmonary circulatory disturbance. The most predominant, common category is pulmonary arterial thromboembolism (PTE). Deep vein thrombosis is the primary source of thrombus causing thromboembolism in the pulmonary artery, by circulating into the pulmonary artery. Blood stasis, increased blood clotting, and venous endothelial damage are contributors to thrombosis. Thus, venous thrombosis is easily induced by trauma, prolonged bed rest, varicose veins, venous cannulas, pelvic and hip surgery, obesity, diabetes, contraceptive agents, or other causes of hypercoagulability. The risk of pulmonary embolism is highest in the first few days of thrombosis.

Pulmonary artery embolism is one of the three common fatal cardiovascular diseases at present, has the characteristics of high incidence rate, high disability rate and high death rate, and is a serious and emergency symptom of respiratory systems. Acute pulmonary embolism is a disorder of pulmonary circulation in acute development, and common symptoms are symptoms such as dyspnea, chest pain, hemoptysis, syncope and the like of patients, and even death of the patients. The main method for treating pulmonary artery embolism is surgical treatment, and the treatment is carried out in time after the pulmonary artery embolism is generated, so that the death of a patient caused by the repeated attack is avoided.

The traditional operation mode for treating pulmonary artery embolism mainly comprises the following steps:

1. thrombolytic therapy

Dissolving thrombus in pulmonary artery, rapidly reducing pulmonary artery pressure, and improving right heart function; reducing or eliminating the influence on the diastolic function of the left ventricle, and improving the left heart function and cardiogenic shock; improving lung perfusion, preventing chronic pulmonary arterial hypertension and long-term prognosis; dissolving deep venous thrombosis and preventing repeated embolism.

2. Anticoagulant therapy

Prevent thrombus development and formation of new thrombus. The results of simple anticoagulation in some high and medium risk PE patients are not ideal. Many doctors try to improve the curative effect by systemic thrombolysis, direct thrombolysis of catheters, or surgical thrombolysis.

3. Breaking up and aspirating thrombi via intravenous catheter

The method is mainly used for cases where large-area PTE of main pulmonary artery or main branches coexist: thrombolysis and anticoagulation therapy contraindications; thrombolytic or active medical treatment is ineffective; lack of surgical conditions, etc.

4. Inferior vena cava filter implantation

The method is mainly used for the following situations: PTE is fully anticoagulated and still repeatedly occurs; large area PTE with hemodynamic changes; before thrombolysis of the proximal large thrombus; chronic repetitive PTE with pulmonary hypertension; a pulmonary arterial thrombectomy or a pulmonary arterial thrombectomy.

5. Pulmonary artery thrombectomy

Surgical thrombolysis and pulmonary intima stripping are highly traumatic in the traditional operation mode.

Current interventions for acute pulmonary embolism mainly include catheter thrombolysis and catheter-based thrombi removal/excision.

Interventional procedures employing an embolectomy have become an effective and important treatment for acute pulmonary embolism. However, the existing thrombus removing device has the problem that thrombus is easy to escape, so that the single thrombus removing amount is low. In addition, the existing thrombus taking device is also in need of improvement in the aspects of convenient conveying or convenient sheath entering and sheath exiting and the like.

Disclosure of Invention

Based on this, it is necessary to provide a thrombus removing device which is advantageous in improving the single thrombus removing amount and is convenient for transportation, or a thrombus removing device which is advantageous in improving the single thrombus removing amount and is convenient for sheath insertion and sheath insertion.

The thrombus taking device comprises a thrombus taking bracket, wherein the thrombus taking bracket comprises an interception net and a plurality of interception members arranged on the interception net at intervals along the circumferential direction of the interception net, the proximal end of each interception member is connected with the interception net, and the distal end is a free end;

the plurality of interception members are positioned outside the interception net in a natural state, each interception member is outwards turned from one end connected with the interception net, and in a stretching state, the outwards turned part can be distally turned;

alternatively, in a natural state, the plurality of interceptors are located inside the interceptor web, and in a stretched state, the plurality of interceptors do not intersect in a radial direction.

In one embodiment, the interception net comprises a first expansion part, the first expansion part comprises a plurality of first grid cells, the first grid cells are connected to form a circumferentially closed grid structure, the interception members are arranged on the first grid cells, in a natural state, the interception members are positioned outside the interception net, the interception members are outwards folded from one end connected with the first grid cells, in a stretching state, the outwards folded part can be folded towards the far end, and the length of the interception members after the outwards folded part is folded towards the far end is smaller than that of the first grid cells.

In one embodiment, the interception net comprises a first expansion part, the first expansion part comprises a plurality of first grid cells, the first grid cells are connected to form a circumferentially closed grid structure, the interception members are arranged on the first grid cells, each interception member comprises two interception rods, the two interception rods are connected to form a distal closed end, one end, far away from the distal closed end, of each interception rod is connected with the first grid cell, and the distal closed end is a free end; or, the interception member comprises two first interception rods and a second interception rod, two ends of the second interception rod are respectively connected with one ends of the two first interception rods, and one end, far away from the second interception rod, of the first interception rod is connected with the first grid unit.

In one embodiment, each first grid cell includes two first proximal rods, two first intermediate rods, and two first distal rods, the two first proximal rods being connected at a proximal end, the two first distal rods being connected at a distal end, the proximal ends of the two first intermediate rods being connected with the distal ends of the two first proximal rods, respectively, the distal ends of the two first intermediate rods being connected with the proximal ends of the two first distal rods, respectively, and two adjacent first grid cells sharing one of the first intermediate rods.

In one embodiment, the hardness of the interceptor member is less than the hardness of the first proximal rod, the first intermediate rod, and the first distal rod.

In one embodiment, the interceptor member has a smaller rod diameter than the first proximal rod, the first intermediate rod and the first distal rod.

In one embodiment, the interception net is provided with a filter membrane, the proximal end of the filter membrane is open, the proximal edge of the filter membrane is in a wave-shaped structure, a plurality of protruding parts are arranged, and a gap is formed between two adjacent protruding parts.

In one embodiment, the thrombus removing device further comprises a filter membrane fixing piece, the filter membrane fixing piece comprises a proximal end fixing portion and a distal end fixing portion connected with the proximal end fixing portion, the proximal end fixing portion is cylindrical, the distal end fixing portion is truncated cone-shaped, the distal end fixing portion extends out of the interception net, the proximal end fixing portion is connected with the interception net, and the distal end of the filter membrane is clamped between the proximal end fixing portion and the interception net.

In one embodiment, the gap between two adjacent bosses is located within the first grid cell.

In one embodiment, the interception net is a first interception part, the thrombus taking device further comprises a second interception part connected with the distal end of the first interception part, and the first interception part is connected with the second interception part through a flexible connecting piece

The thrombus taking device comprises a thrombus taking support, wherein the thrombus taking support comprises an interception net and a plurality of interception pieces which are arranged on the interception net along the circumferential direction of the interception net at intervals.

When the plurality of interception members are positioned outside the interception net in a natural state, and each interception member is turned outwards from one end connected with the interception net, so that the interception capacity of the near end is improved in the circumferential direction, and more thrombus can be intercepted. In addition, in the stretching state, the outwards-folded part can be folded towards the far end, so that the thrombus taking device can be conveyed with a smaller conveying profile, and the conveying is convenient.

When in a natural state, the plurality of interception members are positioned inside the interception net, so that the interception capacity of the near end is improved in the circumferential direction, and more thrombus can be intercepted. In addition, in the stretched state, when the plurality of interceptors do not intersect in the radial direction, the sheath can be conveniently inserted into and taken out of the sheath.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Wherein:

FIG. 1 is a schematic diagram of an exemplary embodiment of a thrombolytic device;

FIG. 2 is a schematic view of an exemplary structure of a thrombolytic stent;

FIG. 3 is a schematic view of the proximal structure of a thrombolytic stent according to an embodiment;

FIG. 4 is a schematic view of a first interception portion of a thrombolytic stent according to an embodiment;

FIG. 5 is a schematic view showing a connection state of an interceptor of the thrombus removal stand and the first grid unit according to an embodiment;

FIG. 6 is a schematic view of the structure of a thrombolytic stent according to an embodiment;

FIG. 7 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 8 is an enlarged view of a portion of FIG. 4;

FIG. 9 is a schematic view of a second interception portion of a thrombolytic stent according to an embodiment;

fig. 10 is a schematic structural view of a second interception portion at another angle;

FIG. 11 is an enlarged view of a portion of FIG. 9;

fig. 12 is a schematic structural view of a thrombus-removing stand with the third interception portion omitted in another embodiment;

fig. 13 is a schematic structural view of a thrombus taking out stent with the third interception portion omitted in another embodiment;

FIG. 14 is a schematic view of the structure of an interceptor member of another embodiment;

FIG. 15 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 16 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 17 is a schematic view of another angle of the thrombolytic stent of FIG. 16;

FIG. 18 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 19 is a schematic view of another angle of the thrombolytic stent of FIG. 18;

FIG. 20 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 21 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 22 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 23 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 24 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 25 is a schematic view of another embodiment of a thrombolytic stent;

FIG. 26 is a schematic view showing the structure of a filter membrane in an open state according to an embodiment;

FIG. 27 is a schematic view showing the structure of a filter holder according to an embodiment;

FIG. 28 is a schematic view of an alternative embodiment of the filter holder of FIG. 27;

FIG. 29 is a schematic view of another embodiment of a thrombolytic stent;

fig. 30 is a schematic structural view of a thrombus-removing stent according to another embodiment.

Reference numerals:

1. a thrombus taking device;

10. a thrombus taking bracket;

110. a first interception portion; 110a, proximal end; 110b, distal end; 111. a first expansion part; 1111. a first grid cell; 1111A, a first proximal shaft; 1111B, a first intermediate lever; 1111C, a first distal rod; 1111a, a first proximal connection; 1111c, a first distal connection; 112. a first proximal connection; 1121. a first proximal connecting rod; 1121A, a connection; 1121B, transition; 113. a first distal connection; 1131. a first distal connecting rod; 1131A, a first straight segment; 1131B, a first strut segment;

120. A second blocking portion; 120a, proximal end; 120b, distal end; 121. a second expansion part; 1211. a second grid cell; 1211A, a second proximal shaft; 1211B, a second intermediate lever; 1211C, a second distal rod; 1211a, a second proximal connection; 1211c, a second distal connection; 122. a second proximal connection; 1221. a second proximal connecting rod; 1221A, a second straight bar section; 1221B, a second strut segment; 123. a second distal connection; 1231. a second distal connecting rod; 1231A, third straight bar section; 1231B, third strut segment;

130. a third interception portion; 131. an interceptor; 1311. an interception bar; 1312. a first interception bar; 1313. a second interception bar; 1314. a free end;

140. a first constriction; 150. a second constriction; 160. a third constriction;

20. a filter membrane; 30. a filter membrane fixing member; 40. pushing rod.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

In the description of the embodiments of the present invention, it should be noted that, as the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like are used for convenience in describing the embodiments of the present invention and simplifying the description, only, and are not intended to indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the embodiments of the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In describing embodiments of the present invention, it should be noted that, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, interchangeably connected, integrally connected, mechanically connected, electrically connected, directly connected, indirectly connected through an intermediary, or in communication between two elements. The specific meaning of the above terms in embodiments of the present invention will be understood in detail by those of ordinary skill in the art.

In the field of interventional medical devices, the end of the medical device implanted in the human or animal body that is closer to the operator is generally referred to as the "proximal end", the end that is farther from the operator is referred to as the "distal end", and the "proximal end" and "distal end" of any component of the medical device are defined in accordance with this principle. "axial" generally refers to the longitudinal direction of a medical device when delivered, and "radial" generally refers to the direction of the medical device perpendicular to its "axial" direction, and defines the "axial" and "radial" directions of any component of the medical device in accordance with this principle.

Referring to fig. 1, a thrombus removing device 1 according to an embodiment includes a thrombus removing stand 10. Referring to fig. 2, the thrombus taking stand 10 includes a first blocking portion 110, a second blocking portion 120 and a third blocking portion 130. The first blocking portion 110 has a proximal end 110a and a distal end 110b, the second blocking portion 120 has a proximal end 120a and a distal end 120b, and the proximal end 120a of the second blocking portion 120 is connected to the distal end 110b of the first blocking portion 110. Referring to fig. 3 (only a portion of the blocking members 131 are labeled), the third blocking portion 130 includes a plurality of blocking members 131, and the plurality of blocking members 131 are disposed on the first blocking portion 110 along a circumferential direction of the first blocking portion 110.

In the above-mentioned thrombus removing device 1, the proximal end 120a of the second interception portion 120 of the thrombus removing stand 10 is connected to the distal end 110b of the first interception portion 110, so as to form two-stage interception in the axial direction; the plurality of interceptors 131 of the third interceptor 130 are disposed on the first interceptor 110 along the circumference of the first interceptor 110, and the intercepting capability of the proximal end is improved in the circumference, which is beneficial to intercepting more thrombus. Thus, the single thrombus taking amount is beneficial to improvement.

Referring to fig. 4, in an embodiment, the first interception portion 110 includes a first expansion portion 111, each interception member 131 extends from a proximal end to a distal end of the first expansion portion 111, and the distal end of the interception member 131 is a free end. In a natural state, the plurality of interceptors 131 are located outside the first expansion portion 111, so that the radial dimension of the third interceptor 130 is greater than the radial dimension of the first interceptor 110, which is beneficial to intercept thrombus. Also, the distal end of the interceptor member 131 is a free end such that the interceptor member 131 can extend freely when axially stretched for delivery, which is advantageous for reducing the delivery profile.

The first expanding portion 111 includes a plurality of first mesh cells 1111, and the plurality of first mesh cells 1111 are connected to form a circumferentially closed mesh structure.

Referring to fig. 4 and 5 together, in one embodiment, the first lattice unit 1111 includes two first proximal rods 1111A, two first middle rods 1111B and two first distal rods 1111C, the two first proximal rods 1111A are connected to form a first proximal connection end 1111A at the proximal end. The two first distal rods 1111C are connected to each other to form a first distal connection end 1111C at the distal end, one ends of the two first intermediate rods 1111B are connected to one ends of the two first proximal rods 1111A, which are far from the first proximal connection end 1111A, respectively, and the other ends are connected to one ends of the two first distal rods 1111C, which are far from the first distal connection end 1111C, respectively. The two first proximal rods 1111A, the two first intermediate rods 1111B, and the two first distal rods 1111C enclose a frame structure. Each first lattice cell 1111 shares a first intermediate rod 1111B with an adjacent first lattice cell 1111, and a plurality of the first lattice cells 1111 constitute a circumferentially closed lattice structure.

Referring back to fig. 4, in an embodiment, the first intercepting portion 110 further includes a first proximal connecting portion 112 and a first distal connecting portion 113, and two ends of the first expanding portion 111 are respectively connected to the first proximal connecting portion 112 and the first distal connecting portion 113, so as to form a grid structure with small ends and large middle. That is, the first proximal end connecting portion 112 converges proximally from the end connected to the first expanding portion 111, and the first distal end connecting portion 113 converges distally from the end connected to the first expanding portion 111.

The first proximal connection 112 converges proximally from the end connected to the first expansion 111, facilitating pulling the thrombus removal device 1 and the intercepted thrombus together into the sheath for removal during a thrombus removal procedure. The second distal connecting portion 113 converges distally from the end connected to the first expanding portion 111, which is advantageous for improving flexibility of the middle portion of the thrombolytic device 1.

Referring to fig. 4 and 6, in one embodiment, the first proximal connection portion 112 includes a plurality of first proximal connection rods 1121. One end of each first proximal connecting rod 1121 is connected to the first proximal connecting end 1111a of the first expansion portion 111, and the other ends of all the first proximal connecting rods 1211 are converged in the first convergence member 140.

In one embodiment, the first proximal connecting rods 1121 are bar-shaped rods, and the number of first proximal connecting rods 1121 is equal to the number of first lattice cells 1111. By the arrangement, on one hand, the first proximal connecting portion 112 can better support the first expanding portion 111, which is beneficial to keeping the first expanding portion 111 in a radial expanding state and avoiding the first intercepting portion 110 from collapsing to make thrombus escape. On the other hand, in the process of withdrawing the thrombus taking stent 10 to bring thrombus into the sheath, the first proximal connecting portion 112 is directly contacted with thrombus, and more first proximal connecting rods 1121 are provided to make the density of the first proximal connecting portion 112 larger so as to intercept more thrombus and increase the single thrombus taking amount.

Referring to fig. 7, in another embodiment, the first proximal connecting rod 1121 includes a connecting portion 1121A and a transition portion 1121B connected to the connecting portion 1121A, one end of the connecting portion 1121A away from the transition portion 1121B is connected to the first converging member 140, and one end of the transition portion 1121B away from the connecting portion 1121A is connected to the first expanding portion 111. The width of the transition portion 1121B gradually decreases from one end near the first expansion portion 111 to one end far from the first expansion portion 111, so that the first proximal connecting rod 1121 can better support the first expansion portion 111.

Referring back to fig. 4, in one embodiment, the first distal connection portion 113 includes a plurality of first distal connection bars 1131. One end of each first distal connecting rod 1131 is connected to the first distal connecting end 1111c of the first expansion part 111, and the other ends of all the first distal connecting rods 1131 are converged in the second convergence member 150.

Referring to fig. 4 and 8 together, in one embodiment, the first distal connecting rod 1131 is a Y-shaped rod, and includes a first straight rod segment 1131A and two first strut segments 1131B connected to one end of the first straight rod segment 1131A. One end of the first straight pole segment 1131A, which is far away from the first pole segment 1131B, is connected to the second convergence member 150, and one ends of the two first pole segments 1131B, which are far away from the first straight pole segment 1131A, are respectively connected to two first distal connection ends 1111c of two adjacent first grid cells 1111.

Referring to fig. 9, in an embodiment, the second interception portion 120 includes a second expansion portion 121, a second proximal connection portion 122, and a second distal connection portion 123. The two ends of the second expansion part 121 are respectively connected with the second proximal end connecting part 122 and the second distal end connecting part 123, so as to form a grid structure with small two ends and large middle.

The second expansion part 121 includes a plurality of second mesh units 1211, and the plurality of second mesh units 1211 are connected to form a circumferentially closed mesh structure.

In one embodiment, the second grid unit 1211 includes two second proximal rods 1211A, two second intermediate rods 1211B, and two second distal rods 1211C, the two second proximal rods 1211A being connected to each other, a second proximal connection end 1211A being formed at a proximal end, the two second distal rods 1211C being connected to each other, and a second distal connection end 1211C being formed at a distal end, one end of the two second intermediate rods 1211B being connected to one end of the two second proximal rods 1211A, respectively, distal to the second proximal connection end 1211A, and the other end being connected to one end of the two second distal rods 1211C, respectively, distal to the second distal connection end 1211C. Two second proximal rods 1211A, two second intermediate rods 1211B, and two second distal rods 1211C enclose a frame structure. Each second grid cell 1211 shares one second intermediate bar 1211B with an adjacent second grid cell 1211, and the plurality of second grid cells 1211 constitute a circumferentially closed grid structure.

With continued reference to fig. 9, in one embodiment, the second proximal connection 122 includes a plurality of second proximal connecting rods 1221. One end of each second proximal connecting rod 1221 is connected to the second proximal connecting end 1211a of the second expansion 121, and the other ends of all the second proximal connecting rods 1221 converge into the second converging member 150.

Referring to fig. 9 and 10 together, in one embodiment, the second proximal connecting rod 1221 is a Y-shaped rod, and includes a second straight rod section 1221A and two second strut sections 1221B connected to one end of the second straight rod section 1221A. One end of the second straight rod section 1221A, which is far from the second strut section 1221B, is connected to the second convergence member 150, and one ends of the two second strut sections 1221B, which are far from the second straight rod section 1221A, are respectively connected to two second proximal connection ends 1211A of the two connected second grid cells 1211.

Referring back to fig. 9, in one embodiment, the second distal connecting portion 123 includes a plurality of second distal connecting rods 1231. One end of each second distal connecting rod 1231 is connected to the second distal connecting end 1211c of the second expansion portion 121, and the other ends of all the second distal connecting rods 1231 are converged in the third convergence 160.

Referring to fig. 9 and 11 together, in one embodiment, the second distal connecting rod 1231 is a Y-shaped rod, and includes a third straight rod segment 1231A and two third strut segments 1231B connected to one end of the third straight rod segment 1231A. One end of the third straight rod segment 1231A, which is far away from the third strut segment 1231B, is connected to the third convergence member 160, and one ends of the two third strut segments 1231B, which are far away from the third straight rod segment 1231A, are respectively connected to the two second distal end connection ends 1211c of the two adjacent second grid units 1211.

The first plurality of distal connecting rods 1131 of the first blocking portion 110 and the second plurality of proximal connecting rods 1221 of the second blocking portion 120 each converge in the second constriction 150. Referring back to fig. 7, in an embodiment, the first distal connecting rods 1131 and the second proximal connecting rods 1221 are offset in the radial direction of the second constriction 150, so that, on one hand, the flexibility of the thrombus taking support 10 is smaller, and on the other hand, the first distal connecting rods 1131 and the second proximal connecting rods 1221 cooperate with each other, so as to increase the interception area, which is beneficial to intercept more thrombus.

In one embodiment, the first distal connecting rod 1131 is a Y-shaped rod, and one end of the first straight rod section 1131A of the first distal connecting rod 1131, which is far away from the first rod section 1131B, is connected to the second constriction 150, and one ends of the two first rod sections 1131B, which are far away from the first rod section 1131A, are connected to two adjacent first grid cells 1111 of the first expansion part 111. And, the second proximal connecting rod 1221 is a Y-shaped rod, one end of the second straight rod section 1221A of the second proximal connecting rod 1221, which is far from the second strut section 1221B, is connected to the second constriction 150, and one ends of the two second strut sections 1221B, which are far from the second straight rod section 1221A, are connected to two adjacent second grid cells 1211 of the second expansion 121. That is, the areas of the connection portions of the first distal connecting rod 1131 and the second proximal connecting rod 1221 with the second constriction 150 are smaller, so that the areas of the connection portions of the first interception portion 110 and the second interception portion 120 with the second constriction 150 are smaller, which is beneficial to improving the flexibility of the thrombus taking stand 10 as a whole. Further, the first distal connecting rod 1131 and the second distal connecting rod 1221 are offset in the radial direction of the second constriction 150, so that the middle portion of the thrombolytic stent 10 is more flexible. Meanwhile, the radial dislocation is realized, so that the flexibility is ensured, and meanwhile, the interception performance is improved. Moreover, the two first strut sections 1131B can better support the first expansion part 111, and the two second strut sections 1221B can better support the second expansion part 121, so that the first interception part 110 and the second interception part 120 can better maintain a radially expanded state to better intercept thrombus, avoid thrombus escape, and improve single thrombus extraction amount.

The second constriction 150 has a ring-like structure. With continued reference to fig. 7, in an embodiment, the portion of the second constriction 150 between two adjacent first distal connecting rods 1131 is concave, and the portion of the second constriction 150 between two adjacent second proximal connecting rods 1221 is concave, so that the second constriction 150 is less compliant.

The first blocking portion 110 and the second blocking portion 120 are connected in the axial direction. When the thrombus is taken out, the first interception part 110 is positioned at the proximal end, the second interception part 120 is positioned at the distal end, the thrombus is intercepted by the first interception part 110 in a first stage, and when the crushed thrombus is generated and escapes from the first interception part 110, the second interception part 120 can intercept the escaped crushed thrombus. Thus being beneficial to capturing escaped thrombus and improving the single thrombus taking amount.

It should be noted that, in other embodiments, the first blocking portion 110 and the second blocking portion 120 are not limited to the above-described structure, and may be other structures. In another embodiment, as shown in fig. 12, the first interception portion 110 includes a first expansion portion 111, a first proximal connection portion 112, and a first distal connection portion 113, and both ends of the first expansion portion 110 are connected to the first proximal connection portion 112 and the first distal connection portion 113, respectively.

The structure of the first expansion portion 111 is the same as that of the first expansion portion 111 in the embodiment shown in fig. 4, and will not be described here again.

The first proximal connection portion 112 includes a plurality of first proximal connection bars 1121, the first distal connection portion 113 includes a plurality of first distal connection bars 1131, and both the first proximal connection bars 1121 and the first distal connection bars 1131 are straight bars. Also, the number of first proximal connecting rods 1121 is equal to the number of first lattice cells 1111 of the first expansion portion 111, and the number of first distal connecting rods 1131 is equal to the number of first lattice cells 1111 of the first expansion portion 111. Each of the first proximal connection rods 1121 has one end connected to the first proximal connection end 1111a of the first expansion portion 111 and the other end connected to the first constriction 140. One end of each first distal connecting rod 1131 is connected to the first distal connecting end 1111c of the first expansion part 111, and the other end is connected to the second constriction 150, thereby forming a structure with a large middle and a small two ends.

The second intercepting part 120 includes a second expanding part 121, a second proximal connecting part 122, and a second distal connecting part 123, and both ends of the second expanding part 121 are connected to the second proximal connecting part 122 and the second distal connecting part 123, respectively.

The structure of the second expansion part 121 is the same as that of the second expansion part 121 in the embodiment shown in fig. 9, and will not be described here again.

The second proximal connecting portion 122 includes a plurality of second proximal connecting rods 1221, the second distal connecting portion 123 includes a plurality of second distal connecting rods 1231, and both the second proximal connecting rods 1221 and the second distal connecting rods 1231 are straight rods. Also, the number of second proximal connecting rods 1221 is equal to the number of second grid cells 1211 of the second expansion 121, and the number of second distal connecting rods 1231 is equal to the number of second grid cells 1211 of the second expansion 121. Each of the second proximal connecting rods 1221 has one end connected to the second proximal connecting end 1211a of the second expansion 121 and the other end connected to the second constriction 150. Each of the second distal connecting rods 1231 has one end connected to the second distal connecting end 1211c of the second expansion part 121 and the other end connected to the third constriction 160, thereby forming a structure having a small proximal end, a large middle and a tapered distal end.

In the embodiment shown in fig. 12, unlike the first intercepting part 110, the second distal connecting rods 1231 of the second intercepting part 120 have a larger length, and all the ends of the second distal connecting rods 1231, which are far away from the second expanding part 121, converge on the third converging member 160, thereby forming a distal tapered structure. So set up for the volume of second interception portion 120 is great, can intercept more thrombus, is favorable to improving single thrombus volume of taking.

Referring to fig. 13, in another embodiment, the first blocking portion 110 and the second blocking portion 120 are both configured with a tapered end. In contrast, the tapered portion of the first interceptor 110 is proximal and the tapered portion of the second interceptor 120 is distal. The proximal end of the first blocking portion 110 is tapered to facilitate the insertion of the blocked thrombus and the embolic stent 10 into the catheter after the thrombus has been blocked. The distal end of the second interception portion 120 is tapered, so that the second interception portion 120 has a larger volume, can intercept more thrombus, and is beneficial to improving the single thrombus taking amount.

It should be noted that, in other embodiments, no matter what the structures of the first proximal connecting rod 1121 and the second distal connecting rod 1231 are, the first proximal connecting rod 1121 and/or the second distal connecting rod 1231 with a larger length may be selected, so that the proximal end of the first interception portion 110 is tapered and/or the distal end of the second interception portion 120 is tapered, so as to facilitate pulling the thrombolytic stent 10 into the sheath tube and/or increasing the volume of the cavity of the second interception portion 120 to intercept more thrombus.

Referring to fig. 3 and 5 together, in an embodiment, in a natural state, the plurality of blocking members 131 are located outside the first blocking portion 110, and the radial dimension of the third blocking portion 130 is greater than that of the first blocking portion 110, so that when the thrombus taking stent 10 is implanted into a blood vessel, the third blocking portion 130 can contact with the blood vessel wall to effectively block thrombus, and the third blocking portion 130 is beneficial to scraping and blocking the thrombus attached to the wall, thereby improving the single thrombus taking amount.

The radial dimension of the first interception portion 110 may refer to a diameter of a circumscribed circle of the first interception portion 110. The radial dimension of the third interceptor 130 may refer to the diameter of the circumscribed circle of the plurality of interceptors 131.

In one embodiment, each interceptor member 131 extends distally from the end connected to the first interceptor portion 110, and the distal end of the interceptor member 131 is a free end, such that the thrombolytic stent 10 has a smaller delivery profile in the stretched state.

With continued reference to fig. 5, in one embodiment, the interceptor member 131 includes two interceptor bars 1311, the two interceptor bars 1311 being connected to form a distal closed end. Two ends of the two interception bars 131 far from the distal closed end are respectively connected with two first proximal bars 1111A, and the distal closed end is a free end.

In one embodiment, the interception member 131 is leaf-shaped, and the distal end of the interception member 131 has a tip structure, which is beneficial to making the overall flexibility of the thrombus taking device 1 better.

It should be noted that, in other embodiments, the interceptor member 131 is not limited to be a tree leaf, but may be other structures. Referring to fig. 14, in another embodiment, the blocking member 131 includes two first blocking rods 1312 and a second blocking rod 1313, two ends of the second blocking rod 1313 are respectively connected to one ends of the two first blocking rods 1312, and one end of the first blocking rod 1312 away from the second blocking rod 1313 is a free end. The free ends of the two first blocking rods 1312 are connected to the two first proximal rods 1111A of the first grid cells 1111, and the first blocking rods 1312 extend axially proximally from the proximal end and the second blocking rods 1313 extend substantially circumferentially. The interceptor 131 of this embodiment can also improve the interception effect, reduce the risk of thrombus escaping, and the free end of the interceptor 131 is not a tip structure, which is advantageous in avoiding the damage of the interceptor 131 to the blood vessel.

Regardless of the shape of the interceptor 131, in one embodiment, in the stretched state, the length of the interceptor 131 is less than the length of the first cells 1111. That is, in the stretched state, the interceptor member 131 extends inside the first mesh unit 1111, and the distal closed end of the interceptor member 131 does not overlap any one of the first proximal rod 1111A, the first intermediate rod 1111B, and the second distal rod 1111C. Therefore, the provision of the third interception portion 130 does not significantly increase the delivery profile of the thrombolytic device 1 nor the rigidity of the thrombolytic device 1.

In one embodiment, the hardness of the interception portion 130 is less than the hardness of the first expansion portion 111. Specifically, the hardness of each of the interception bar 1311, the first interception bar 1312, and the second interception bar 1313 is less than the hardness of any one of the first proximal bar 1111A, the first intermediate bar 1111B, and the second distal bar 1111C. The interception part 130 with smaller hardness is beneficial to avoiding the interception part 130 from stimulating the blood vessel wall and ensuring better flexibility of the thrombus taking device 1.

In an embodiment, the stem diameters of the interception rod 1311, the first interception rod 1312, and the second interception rod 1313 are each smaller than the stem diameters of the first proximal rod 1111A, the first intermediate rod 1111B, and the second distal rod 1111C, such that the hardness of the interception portion 130 is less than the hardness of the first expansion portion 111.

In one embodiment, the plurality of interceptors 131 are in one-to-one correspondence with the plurality of first mesh units 1111, i.e., one interceptor 131 is connected with one first mesh unit 1111.

It should be noted that, in other embodiments, when the number of the first grid cells 1111 is greater, the intercepting members 131 may be disposed at intervals of one first grid cell 1111, that is, the number of the first grid cells 1111 is twice the number of the intercepting members 131, so as to ensure a certain intercepting capability, flexibility and smaller conveying profile.

Referring to fig. 15, in an embodiment, a plurality of intercepting members 131 are located outside the first intercepting part 110. The planes in which the two first intermediate bars 1111B of the first mesh unit 1111 defining the first expansion part 111 are located are planes a (not shown), and each interceptor member 131 forms an angle of 0 ° to 45 ° with the plane a of the first mesh unit 1111 in which it is located.

When the angle formed by the interception member 131 and the plane A of the first grid unit 111 where the interception member 131 is positioned is 0 degrees, the interception member 131 is parallel to the longitudinal central axis B-B of the thrombus taking support 10, so that the free end of the interception member 131 is prevented from being inclined outwards to stimulate the vessel wall when being implanted into the vessel, and the vessel injury is prevented.

When the angle formed by the interception member 131 and the plane a of the first grid cell 111 where the interception member 131 is located is greater than 0 °, the interception member 131 is outwardly expanded with respect to the first grid cell 1111, which is advantageous for intercepting thrombus. At the same time, the angle formed by the interception member 131 and the plane A of the first grid unit 111 where the interception member 131 is positioned is limited to be within 45 degrees, so that the irritation of the free end of the interception member 131 to the blood vessel wall is reduced.

In an embodiment, each interceptor 131 forms an angle of 0 ° to 45 ° with the plane a of the first grid unit 1111 where it is located, and the interceptor 131 has a smaller hardness, so as to be beneficial to slow down the stimulation of the vessel wall on the premise of being able to intercept more thrombus. Ways to achieve the lesser stiffness of the interceptor member 131 include, but are not limited to, using a thinner wire to make the interceptor member 131, or cutting to form the interceptor member 131 with a smaller rod diameter or radial dimension, or other treatments, such as polishing, to make the interceptor member 131 less stiff.

In one embodiment, each interceptor member 131 makes an angle of greater than or equal to 0 ° with respect to plane a of the first lattice 1111 in which it is located, such that in the stretched state, the interceptor member 131 extends inside the first lattice 1111 and the plurality of interceptor members 131 do not intersect in the radial direction to avoid interference when the stent 10 is pulled back into the sheath during the thrombus extraction.

Referring to fig. 16 and 17, in an embodiment, in a natural state, the interception member 131 is turned outwards from an end connected to the first grid element 1111, so that the free end 1314 of the interception member 131 faces the first converging member 140, which is beneficial for avoiding damaging the vessel wall. Also, the end of the interceptor member 131 remote from the first cells 1111 is a free end so that in the stretched state the everted portion can be turned distally to enable delivery with a smaller delivery profile. Further, in the stretched state, the length of the interceptor member 131 after the everting portion is turned distally is smaller than the length of the first mesh unit 1111, i.e. the interceptor member 131 in the stretched state extends within the first mesh unit 1111 to reduce the delivery profile and to improve the compliance.

The first blocking portion 110 of the above-mentioned thrombus taking stent 10 includes a first expansion portion 111 and a first proximal end connecting portion 112 and a second proximal end connecting portion 113 connected to both ends of the first expansion portion 111, respectively, the first lattice unit 1111 of the first expansion portion 111 is a frame structure including a first proximal end rod 1111A, a first intermediate rod 1111B and a first distal end rod 1111C, on the one hand, the first lattice unit 1111 of the frame structure is provided so that the first lattice unit 1111 can be engaged with the blocking member 131, and when the third blocking portion 130 is located outside the first blocking portion 110, in a stretched state, the blocking member 131 can extend in the first lattice unit 1111, which is advantageous for reducing a conveying profile and improving flexibility. In the natural state and the release state, at least part of the interception member 131 is opposite to the area surrounded by the first grid unit 1111, which is favorable for improving the interception capability of the thrombus taking bracket 10, thereby improving the single thrombus taking amount. Therefore, the third blocking portion 130 is provided in the connection manner with the first blocking portion 110, so that the flexibility and blocking performance of the delivery can be ensured, as compared with the manner in which the knitting density of the thrombolytic stent is simply increased or the density of the support rods of the thrombolytic stent is increased in order to improve the blocking performance.

Referring to fig. 18 and 19, in an embodiment, in a natural state, the third interception portion 130 is located inside the first interception portion 110. That is, each interceptor 131 is located inside the first interceptor 110. Also, each interceptor 131 is connected to two first intermediate rods 1111B of the corresponding first grid cell 1111. The third interception portion 130 is located inside the first interception portion 110, and can also improve the interception capability of the proximal end in the circumferential direction, which is beneficial to intercept more thrombus. Thus, the single thrombus taking amount is beneficial to improvement. And, the third interception portion 130 is located inside the first interception portion 110, which is beneficial to avoiding the free end of the interception member 131 from irritating the vessel wall and reducing the delivery profile of the thrombus taking stent 10.

In one embodiment, the interceptors 131 extend inside the primary cells 1111 in a stretched state, and the plurality of interceptors 131 do not intersect in the radial direction to avoid interference when pulling the stent 10 back into the sheath during the embolectomy.

When the third intercepting part 130 is disposed inside the first intercepting part 110, the plurality of intercepting members 131 may not cross in the radial direction in a stretched state by controlling the length of the intercepting members 131, reasonably setting the shape of the intercepting members 131, and the like. For example, an interceptor member 131 as shown in fig. 14 is employed. As another example, a smaller length of interceptor member 131 is used.

In one embodiment, the thrombolytic stent 10 is made of a metallic material. For example, the thrombolytic stent 10 is made of a metal material such as nickel-titanium alloy or stainless steel.

In an embodiment, the first intercepting part 110, the second intercepting part 120, the third intercepting part 130, the first converging member 140, the second converging member 150, and the third converging member 160 are integrally formed. For example, by cutting a metal tube and then shaping.

Referring to fig. 20, in an embodiment, the thrombus taking stand 10 includes a first blocking portion 110, a second blocking portion 120, a third blocking portion 130 and a fourth blocking portion 140, wherein a distal end of the first blocking portion 110 is connected to a proximal end of the second blocking portion 120, the third blocking portion 130 includes a plurality of blocking members 131, the plurality of blocking members 131 are disposed on the first blocking portion 110 along a circumferential direction of the first blocking portion 110, the fourth blocking portion 140 includes a plurality of blocking members 141, and the plurality of blocking members 141 are disposed on the second blocking portion 120 along Zhou Xiangshe of the second blocking portion 120. In one embodiment, the interceptor member 131 shown in fig. 20 is the same structure as the interceptor member 131 shown in fig. 5. The intercepting member 141 has the same structure as the intercepting member 131.

By providing the third intercepting part 130 on the first intercepting part 110 and the fourth intercepting part 140 on the second intercepting part 120, the intercepting performance of the thrombus taking support 10 is improved, and thus, the single thrombus taking amount is improved. Moreover, by the structural cooperation of the blocking member 131 and the first blocking portion 110, the blocking member 140 and the second blocking portion 120 have better flexibility than a method of simply increasing the knitting density of the thrombus-taking stand or increasing the density of the support rod of the thrombus-taking stand in order to increase the blocking performance.

The third blocking portion 130 of the embodiment shown in fig. 20 is disposed inside the first blocking portion 110, and the fourth blocking portion 140 is disposed inside the second blocking portion 120. In another embodiment, referring to fig. 21, the third interception portion 130 is disposed outside the first interception portion 110, and the fourth interception portion 140 is disposed outside the second interception portion 120. It is understood that in other embodiments, the third interception portion 130 may be disposed inside the first interception portion 110, and the fourth interception portion 140 is disposed outside the second interception portion 120. Alternatively, the third interception part 130 may be disposed outside the first interception part 110, and the fourth interception part 140 may be disposed inside the second interception part 120.

In one embodiment, the first blocking portion 110 and the second blocking portion 120 are connected by a flexible connection so that the thrombus formation stent 10 is more compliant to pass through a curved anatomy. Alternatively, the angles of the first blocking portion 110 and the second blocking portion 120 are made adjustable to accommodate the anatomy of different individuals.

Referring to fig. 22, in one embodiment, the first blocking portion 110 and the second blocking portion 120 are connected by a flexible connection 170. The flexible connector 170 is a hollow metal tube with helical slots, and the metal tube is cut to form the helical slots, resulting in the flexible connector 170.

In an embodiment, the first intercepting part 110, the second intercepting part 120, the third intercepting part 130, the first constriction member 140, the third constriction member 160 and the flexible connecting member 170 are integrally formed by cutting, and the flexible connecting member 170 is used to replace the second constriction member 150 to improve flexibility.

Referring to fig. 23, in another embodiment, the flexible connection unit 170 is a coil spring, the distal end of the first interception portion 110 is converged at the first middle converging unit 150A, the proximal end of the second interception portion 120 is converged at the second middle converging unit 150B, and two ends of the coil spring are respectively connected to the first middle converging unit 150A and the second middle converging unit 150B.

Referring to fig. 24, in another embodiment, the flexible connection unit 170 is a flexible linear structure and includes at least two flexible wires 171, and the flexible wires 171 may be, for example, nickel-titanium wires. One end of the elastic wire 171 is connected to the first intercepting part 110, and the other end is connected to the second intercepting part 120. In a natural state, the elastic wire 171 has a bent structure, and when being stressed, the elastic wire 171 can be deformed so that the distance or angle between the first blocking portion 110 and the second blocking portion 120 can be adjusted.

Referring to fig. 25, in another embodiment, the flexible connection member 170 includes a first connection ring 171 and a second connection ring 172, the first blocking portion 110 is connected to the first connection ring 171, the second blocking portion 120 is connected to the second connection ring 172, the first connection ring 171 and the second connection ring 172 are hooked, the first connection ring 171 and the second connection ring 172 are only hooked or overlap, and the first connection ring 171 and the second connection ring 172 are not fixed, so that an angle between the first blocking portion 110 and the second blocking portion 120 can be adjusted, and the thrombus taking stand 10 is easy to pass through a curved lumen structure.

Referring back to fig. 1, in an embodiment, the second interception portion 120 is provided with a filter 20, and blood flow can pass through the filter 20, but thrombus cannot pass through the filter, so as to intercept thrombus with smaller size, and improve the single thrombus taking amount.

In one embodiment, the filter 20 is housed in the second interception portion 120. In another embodiment, the filter 20 is coated on the surface of the second interception portion 120.

In an embodiment, the material of the filter 20 is a flexible polymer material such as nylon or polyester, and the filter 20 is connected to the second interception portion 120 by stitching. The filter membrane 20 is made of a flexible material, which does not significantly increase the stiffness of the stent 10, on the one hand, without significantly increasing the size of the delivery sheath, and on the other hand, without significantly increasing the withdrawal force of the stent 10 during the thrombus removal procedure.

In one embodiment, the filter 20 is housed in the second interception portion 120. As shown in FIG. 26, filter membrane 20 is a bag-like structure having axially opposed proximal and

distal ends

210, 220. Distal end 220 is connected to third constriction 160 and proximal end 210 is connected to second expansion 121 by stitching. Wherein proximal end 210 forms an open end and distal end 220 forms a closed end.

In one embodiment, filter 20 is a bag-like structure with a large proximal end 210 and a small distal end 220.

In one embodiment, the proximal edge of the filter 20 has a wave-like configuration with a plurality of protrusions 230 and a gap 240 between two adjacent protrusions 230. A plurality of bosses 230 are coupled to the second expansion 121 using a suture. In general, to increase the amount of single-shot thrombus removal, and the filter is made of a flexible material, it is common in the art to provide a larger volume of filter as much as possible without forming a gap at the proximal end of the filter to avoid thrombus escape. The applicant has surprisingly found that combining the filter membrane 20 with the proximal edge in a wave-shaped structure with the thrombus-taking stent 10 comprising the first interception portion 110, the second interception portion 120 and the third interception portion 130 enables to obtain a higher single thrombus-taking amount, the proximal edge of the filter membrane 20 is provided in a wave-shaped structure with a gap 240, during the process of pulling the thrombus into the sheath tube, the filter membrane at the proximal end is prevented from being squeezed together to increase the resistance of the sheath, which is beneficial to reducing the withdrawal force of withdrawing the thrombus-taking stent 10, so that the thrombus is easier to push into the sheath tube, and simultaneously, the thrombus is prevented from escaping due to secondary crushing caused by the extrusion of the thrombus with high resistance of the sheath, which is beneficial to improving the single thrombus-taking amount and improving the safety. Compared with the structure that the proximal end of the filter membrane 20 is arranged in a flush shape and does not contain the gap 240, the single thrombus taking amount is higher and the safety is higher.

Returning to fig. 1, in one embodiment, the thrombolytic device 1 further comprises a filter holder 30. The filter holder 30 is used to hold the distal end of the filter 20.

Referring to fig. 27 and 28 together, in one embodiment, the filter holder 30 includes a proximal fixing portion 310 and a distal fixing portion 320 connected to the proximal fixing portion 310, a through hole 330 is formed in the middle of the filter holder 30, and the through hole 330 extends along the axial direction of the filter holder 30 and penetrates through the proximal fixing portion 310 and the distal fixing portion 320. A through hole 330 is provided for passage of the guidewire.

The proximal fixing portion 310 has a cylindrical shape, the distal fixing portion 320 has a truncated cone shape, and the distal end of the proximal fixing portion 310 is connected to the end of the distal fixing portion 320 having a larger bottom area. The outer diameter of the proximal fixing portion 310 is smaller than the outer diameter of the end face of the end of the distal fixing portion 320 where the bottom area is larger.

The third constriction 160 has a ring-like structure. In one embodiment, the distal end of filter membrane 20 extends into third constriction 160. The proximal fixing portion 310 of the filter fixing member 30 is inserted into the third constriction 160, and the proximal end surface of the distal fixing portion 320 abuts against the third constriction 160. The distal end of filter membrane 20 is held by third constriction 160 and proximal fixation portion 310. The proximal end fixing portion 310 of the filter membrane fixing member 30 is inserted into the third constriction member 160, and the proximal end fixing portion 310 and the third constriction member 160 are fixedly connected, so that the distal end of the filter membrane fixing member 30 is fixedly connected with the thrombus taking-out stent 10.

It should be appreciated that, in other embodiments, after the proximal fixing portion 310 of the filter fixing member 30 is inserted into the third constriction 160, in addition to the abutting connection, the proximal fixing portion 310 may be further fixedly connected to the third constriction 160 by adopting an adhesive or welding method, so as to improve the reliability of the connection.

The distal end of the filter membrane 20 is fixed by the filter membrane fixing member 30, and the proximal end of the filter membrane 20 is sutured to the second expansion portion 121, so that the proximal end 210 of the filter membrane 20 is opened when the second interception portion 120 is unfolded, so that thrombus is intercepted. The filter membrane fixing member 30 can support and fix the distal end of the filter membrane 20 to prevent the filter membrane 20 from being inclined to prevent thrombus from being effectively intercepted. The filter membrane fixing piece 30 is arranged, and a supporting rod penetrating through the thrombus taking support 10 is not required to be arranged for supporting, so that the thrombus taking device 1 is good in flexibility.

And, the distal end fixing portion 320 of the filter membrane fixing member 30 has a truncated cone shape, and the end of the distal end fixing portion 320 having a smaller bottom surface is a distal end, so that the thrombus-taking stand 10 is advantageously positioned at the distal end of the thrombus through the thrombus for performing the thrombus-taking operation.

In other embodiments, the filter 20 may be omitted, and the second interception portion 120 may be woven with a woven wire to form a filter screen with a closed distal end and an open proximal end.

It should be noted that, in other embodiments, the third interception portion 130 of the thrombus taking stand 10 may be disposed on the second interception portion 120 instead of the first interception portion 110.

Referring to fig. 29, another embodiment of a thrombolytic stent 10 'includes a first blocking portion 110', a second blocking portion 120 'and a third blocking portion 130'. The first blocking portion 110 'and the first blocking portion 110 have substantially the same or identical structures, and the second blocking portion 120' and the second blocking portion 120 have substantially the same or identical structures. The third intercepting part 130' includes a plurality of intercepting members 131', and the plurality of intercepting members 131' are disposed on the second intercepting part 120' along a circumferential direction of the second intercepting part 120 '.

The third interception portion 130 'is disposed on the second interception portion 120' located at the distal end, and the first interception portion 110 'and the second interception portion 120' are engaged, so that interception performance can be improved in the radial and axial directions.

When the third interception portion 130' is disposed on the second interception portion 120' located at the distal end, the filter 20 may be disposed on the second interception portion 120' or the filter 20 may not be disposed. The provision of the filter membrane 20 is advantageous for further enhancing the interception performance.

Referring back to fig. 1, in one embodiment, the thrombolytic device 1 further includes a pushing rod 40, and the pushing rod 40 is connected to the first constriction 140. The pushing rod 40 is used to push the thrombolytic stent 10 for thrombolysis.

Referring to fig. 30, in another embodiment, another thrombolytic stent 10' is provided. The thrombus-taking out stand 10' includes an interception net 110' and a plurality of interception members 120' disposed on the interception net 110' at intervals along a circumferential direction of the interception net 110 '.

The structure of the interception net 110' is the same as that of the first interception part 110, or the structure of the interception net 110' is the same as that of the second interception part 120, and the structure and connection manner of the interception member 120' are the same as those of the interception member 131, which will not be repeated here.

The thrombus removing stent 10' of the present embodiment only includes one interception net 110', and a plurality of interception members 120' are disposed on the interception net 110', so that on one hand, the axial length of the thrombus removing stent 10' is shorter, which is beneficial to removing thrombus near the closed end of the blood vessel or near the reduced diameter portion of the blood vessel. On the other hand, the blocking net 110 'and the blocking member 120' cooperate to enhance radial blocking performance.

It will be appreciated that in this embodiment, a filter membrane may be disposed on the interception net 110' to enhance interception performance. The filter membrane is disposed in the same manner as the filter membrane 20 is disposed on the second intercepting part 120, that is, the distal end of the filter membrane is connected to the distal end of the interception net 110' through the filter membrane fixing member 30', and the proximal end of the filter membrane is fixed on the expanding part of the interception net 110' by means of stitching. And will not be described in detail herein.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The foregoing disclosure is illustrative of the present invention and is not to be construed as limiting the scope of the invention, which is defined by the appended claims.

Claims

1. The thrombus taking device is characterized by comprising a thrombus taking bracket, wherein the thrombus taking bracket comprises an interception net and a plurality of interception members arranged on the interception net at intervals along the circumferential direction of the interception net, the proximal end of each interception member is connected with the interception net, and the distal end is a free end;

2. The embolectomy device of claim 1 wherein the retaining net comprises a first expansion portion comprising a plurality of first grid cells connected to form a circumferentially closed grid structure, the retaining members are disposed on the first grid cells, the retaining members are positioned outside the retaining net in a natural state, the retaining members are folded outwardly from an end connected to the first grid cells, the folded-out portion is folded distally in a stretched state, and the retaining members after the folded-out portion is folded distally have a length less than the length of the first grid cells.

3. The embolectomy device of claim 1 wherein the retaining net comprises a first expansion portion comprising a plurality of first grid cells connected to form a circumferentially closed grid structure, the retaining members disposed on the first grid cells, each retaining member comprising two retaining bars connected to form a distal closed end, one end of the two retaining bars distal to the distal closed end being connected to the first grid cell, the distal closed end being a free end; or, the interception member comprises two first interception rods and a second interception rod, two ends of the second interception rod are respectively connected with one ends of the two first interception rods, and one end, far away from the second interception rod, of the first interception rod is connected with the first grid unit.

4. The thrombolytic device according to claim 2 or 3, wherein each of said first grid cells comprises two first proximal rods, two first intermediate rods and two first distal rods, said two first proximal rods being proximally connected, said two first distal rods being distally connected, said proximal ends of said two first intermediate rods being respectively connected to distal ends of said two first proximal rods, said distal ends of said two first intermediate rods being respectively connected to proximal ends of said two first distal rods, and wherein adjacent two of said first grid cells share one of said first intermediate rods.

5. The thrombectomy device of claim 4, wherein the hardness of the interceptor member is less than the hardness of the first proximal shaft, the first intermediate shaft and the first distal shaft.

6. The thrombectomy device of claim 4, wherein the interceptor member has a smaller stem diameter than the first proximal stem, the first intermediate stem and the first distal stem.

7. The thrombolytic device according to claim 4, wherein said interception net is provided with a filter membrane, a proximal end of said filter membrane is opened, and a proximal end edge of said filter membrane has a wave-shaped structure, and a plurality of protrusions are provided, and a gap is provided between two adjacent protrusions.

8. The thrombolytic device according to claim 7, further comprising a filter fixing member, wherein said filter fixing member comprises a proximal fixing portion and a distal fixing portion connected to said proximal fixing portion, said proximal fixing portion is cylindrical, said distal fixing portion is truncated cone-shaped, said distal fixing portion extends out of said interception net, said proximal fixing portion is connected to said interception net, and a distal end of said filter is clamped between said proximal fixing portion and said interception net.

9. The thrombolytic device of claim 8, wherein a gap between two adjacent bosses is located within said first grid cell.

10. The thrombectomy device of claim 1, wherein the blocking mesh is a first blocking portion, the thrombectomy device further comprising a second blocking portion connected to a distal end of the first blocking portion, the first blocking portion being connected to the second blocking portion by a flexible connector.