CN116115320A - Pulse ablation device - Google Patents

Abstract

The invention discloses a pulse ablation device which comprises a main pipe body, a self-expanding bracket, a hard guide wire, at least one ablation electrode and at least one electrode pin; the distal end of the main pipe body is connected with the proximal end of the self-expanding bracket, the distal end of the main pipe body is provided with a first opening, and the proximal end of the main pipe body is provided with a second opening communicated with the first opening; the main pipe body is internally penetrated with a hard guide wire, the distal end of the hard guide wire is abutted against the distal end of the self-expanding bracket, and the self-expanding bracket can be driven by the hard guide wire to be switched from an expanding state to a contracting state and can be automatically switched from the contracting state to the expanding state when the hard guide wire is not driven; the self-expanding stent has a maximum diameter in an expanded state and a minimum diameter in a contracted state, the maximum diameter being greater than the diameter of the main tubular body; the ablation electrode is arranged in the main pipe body and is close to the distal end of the main pipe body, and the ablation electrode is electrically connected with the electrode pins. Therefore, accurate positioning ablation can be realized without the help of external image products.

Description

Pulse ablation device

Technical Field

The invention relates to the technical field of medical equipment, in particular to a pulse ablation device.

Background

Benign Prostatic Hyperplasia (BPH) is a common disorder in older men, and is caused by cellular proliferation, not by hypertrophy of cells. BPH is strictly a histopathologically diagnostic, and clinically results in enlarged prostate, which can cause bladder outlet obstruction due to enlarged prostate, ultimately leading to a series of lower urinary tract symptoms associated with lower urinary tract obstruction (LUTS). Clinical statistics data show that the requirement on the curative effect of the operation is increasingly raised due to the improvement of the life quality of people, and the requirements on the post-operation recovery time, the functional nerve retention condition of the prostate and the like are increased from the previous requirement of purely solving the hyperplasia of the prostate.

The current methods for treating prostatic hyperplasia mainly comprise: drug therapy, surgical therapy and interventional therapy. The transurethral prostatectomy (TURP) written on the guide for treating prostatic hyperplasia is used as a gold standard for prostatic hyperplasia, and is mainly used by doctors for treating prostatic hyperplasia. However, the operation can destroy the prostate blood vessel and the nerve, which results in the phenomenon of great bleeding amount in operation and postoperative hematuria, and the postoperative recovery time is long, and the sexual function of the patient can be damaged. There are, of course, many new surgical treatments besides TURP, such as: radio frequency therapy, microwave therapy, laser therapy and cryotherapy. It is characterized by that it utilizes high-temperature or low-temperature to destroy proliferation tissue so as to attain the goal of curing hyperplasia.

Different from temperature treatment, the principle of pulse treatment is that irreversible electroporation is utilized, and different from physiotherapy based on the principle of thermal ablation such as radio frequency, microwave, freezing, ultrasonic focusing and the like, the technology applies a high-voltage pulse electric field with microsecond level pulse width around a targeted cell, so that the stability of the surface of a tumor cell membrane can be destroyed, a plurality of hydrophilic micropores are formed on the surface of the tumor cell membrane, the cell steady state is destroyed, and finally, the cell death is caused. The technique can selectively kill pathological tissues, effectively retain blood vessels and nerves of the prostate, thereby reducing the condition of postoperative hematuria and retaining the prostate function of a patient. The existing treatment of prostatic hyperplasia by irreversible electroporation can be performed in two ways:

firstly, percutaneous puncture technology. The percutaneous puncture technology is a technology for entering a human body by utilizing a puncture needle under the guidance of an imaging device, on one hand, the percutaneous puncture needs X-ray or CT ray auxiliary positioning, and the matched use of the CT imaging device ensures that a patient and medical staff are in strong radiation. On the other hand, the puncturing process is very dependent on the manipulation and experience of doctors, the blood vessels and nerves of the prostate or the periphery of the prostate are densely distributed, and the blood vessels and nerves can be punctured by a little careless, so that the prostate is bleeding or the nerves are damaged, and unnecessary secondary injury is caused. In addition, in patients with irregular prostate positions, in-vitro puncture positioning is difficult.

And secondly, a transurethral puncture technology. Transurethral puncture techniques also rely heavily on the skill and experience of the physician. Meanwhile, most transurethral products are required to be matched with an endoscope, the position of the prostate is positioned through the endoscope, and the transurethral products extend into the prostatic hyperplasia part through a natural cavity (transurethral or rectal) to perform prostatic hyperplasia treatment. This approach requires a thicker delivery system and is painful for the patient. Especially for patients encountering urethral strictures, such procedures are not operable. With the use of irreversible electroporation, there is also the possibility of electromagnetic interference between the two active devices, resulting in prolonged surgical time and reduced surgical safety.

Disclosure of Invention

In view of the above-mentioned shortcomings of the prior art, the pulse ablation device provided in the embodiments of the present application can achieve precise positioning ablation without using an external image product.

The invention provides a pulse ablation device, which comprises a main pipe body, a self-expanding bracket, a hard guide wire, at least one ablation electrode and at least one electrode pin, wherein the main pipe body is provided with a plurality of electrodes;

the distal end of the main pipe body is connected with the proximal end of the self-expanding bracket, the distal end of the main pipe body is provided with a first opening, the proximal end of the main pipe body is provided with a second opening, the second opening is communicated with the first opening, the main pipe body is internally penetrated with the hard guide wire, the distal end of the hard guide wire can be abutted with the distal end of the self-expanding bracket, the self-expanding bracket can be driven by the hard guide wire to be switched from an expanding state to a contracting state, and the self-expanding bracket can be automatically switched from the contracting state to the expanding state when the hard guide wire is not driven; the self-expanding stent has a maximum diameter in an expanded state and a minimum diameter in a contracted state, the maximum diameter being greater than the diameter of the main tubular body;

the at least one ablation electrode is disposed within the main tubular body proximate a distal end of the main tubular body, the ablation electrode being electrically connected to the electrode pin.

Further, the self-expanding stent comprises a plurality of self-expanding elements circumferentially arranged around the axis of the main tube body, wherein the proximal ends of the plurality of self-expanding elements are connected with the distal end of the main tube body, the distal ends of the plurality of self-expanding elements are folded towards the axis direction of the main tube body, and the diameters of the self-expanding elements gradually increase from two ends to the middle.

Further, the self-expanding element is made of a shape memory material.

Further, the self-expanding element is made of a memory silica gel material.

Further, the proximal end of the stiff guidewire extends beyond the proximal end of the main tubular body.

Further, an axial stop structure is included for defining the relative position of the stiff wire and the main tube body in an axial direction of the main tube body.

Further, the axial limiting structure comprises a first matching limiting part and a second matching limiting part, the first matching limiting part is arranged at the proximal end of the hard guide wire, the second matching limiting part is arranged at the proximal end of the main pipe body, and the hard guide wire and the main pipe body can be matched and limited through the first matching limiting part and the second matching limiting part.

Further, a liquid level observation portion is arranged on the main pipe body, the distal end of the liquid level observation portion is close to the proximal end of the ablation electrode, the proximal end of the liquid level observation portion is close to the proximal end of the main pipe body, and the liquid level observation portion is used for observing the liquid level in the main pipe body.

Further, a plurality of the ablation electrodes are disposed at intervals along the axial direction of the main tube body.

Further, the ablation device also comprises at least one ablation controller, wherein the at least one ablation controller is arranged outside the main pipe body, and the ablation electrode is electrically connected with the electrode pin.

Further, the electrode pin is arranged at the other end of the branch pipe body.

The implementation of the invention has the following beneficial effects:

the pulse ablation device provided by the invention judges the arrival position of the product by utilizing the pressure difference between the inside and outside of the bladder, and positions the position range of the ablation tissue of the prostate by the position of the prostate and the bladder, so that the accurate positioning ablation can be realized under the condition of not using an external image product, the electromagnetic interference during pulse generation is avoided, and the safety and the effectiveness of the operation are improved. Meanwhile, the device can be directly used as a catheter, stays for 7 days in the body, can be directly connected with a pulse wiring for pulse emission treatment if the treatment is required to be received again, and does not need to be intervened again.

Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.

Drawings

In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained from these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic view of a pulse ablation device according to an embodiment of the present invention;

FIG. 2 is a schematic view of a pulse ablation device according to an embodiment of the present invention;

FIG. 3 is a schematic view of a pulse ablation device according to an embodiment of the present invention in vivo;

FIG. 4 is a schematic view of a partial structure of a self-expanding stent as seen from a distal end to a proximal end according to an embodiment of the present invention;

fig. 5 is a schematic view of another deployed state of a pulse ablation device according to an embodiment of the present invention.

The device comprises a main tube body 1, a self-expanding bracket 2, a self-expanding element 21, a hard 3-guide wire, an ablation electrode 4, an axial 5-limiting structure 51, a first matching limiting part 52, a second matching limiting part 6, an ablation controller 7, a branch tube body 8, a prostate 9, a bladder 91 and urine.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described in the following description with reference to the drawings in the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic may be included in at least one implementation of the invention. In the description of the present invention, it should be understood that the directions or positional relationships indicated by the terms "upper", "lower", "left", "right", "top", "bottom", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may include one or more of the feature, either explicitly or implicitly. Moreover, the terms "first," "second," and the like, are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate such that the embodiments of the invention described herein may be implemented in sequences other than those illustrated or otherwise described herein.

The pulse ablation device provided by the embodiment of the invention can be used for prostate ablation treatment. However, the present invention is not limited thereto, and the technical solution provided by the embodiments of the present invention may also ablate other physiological structures having structures and positional relationships similar to those of the bladder and the prostate. Embodiments of the present invention will be described below with reference to prostate ablation, using the end of the main body near the patient as the distal end, and the end of the main body near the operator as the proximal end.

As shown in fig. 1 and 2, a pulse ablation device according to an embodiment of the present invention includes a main tube body 1, a self-expanding stent 2, a stiff guidewire 3, at least one ablation electrode 4, and at least one electrode pin. The distal end of the main pipe body 1 is connected with the proximal end of the self-expanding bracket 2, the distal end of the main pipe body 1 is provided with a first opening, and the proximal end of the main pipe body 1 is provided with a second opening communicated with the first opening; a hard guide wire 3 penetrates through the main pipe body 1, the distal end of the hard guide wire 3 can be abutted against the distal end of the self-expanding bracket 2, the self-expanding bracket 2 can be driven by the hard guide wire 3 to be switched from an expanding state shown in fig. 1 to a contracting state shown in fig. 2, and the self-expanding bracket can be automatically switched from the contracting state to the expanding state when the hard guide wire 3 is not driven; at least one ablation electrode 4 is arranged within the main tubular body 1 and near the distal end of the main tubular body 1, the ablation electrode 4 being electrically connected to the electrode pins.

The prior ablation operation needs to be matched with an endoscope for use, increases the size of transurethral intervention, increases the uncomfortable feeling of patients, and especially can not be operated for patients with urinary tract stenosis. The pulse ablation device provided by the embodiment of the invention does not need to consider adapting to an endoscope channel or being matched with an endoscope to intervene in the urethra, and in the process of inserting the main pipeline into the urethra, the self-expanding stent 2 can keep a contracted state.

The existing ablation procedure is to observe whether the instrument reaches the position of the prostate through the cooperation of an endoscope, and then begin ablation. In the embodiment of the invention, the far end of the main pipe body 1 is provided with a first opening, and the near end of the main pipe body 1 is provided with a second opening communicated with the first opening; the distal end of the main tubular body 1 enters the urethra through the urethral orifice and when inserted into the urethral site, is visible at the main tubular body 1, temporarily without urine in the tube. When the self-expanding body reaches the bladder, urine flows out from the sub-expanding body along the main body 1 due to the pressure inside the bladder itself until the urine reaches a stable state outside and inside the main body 1 when the internal pressure of the bladder is balanced with the pressure outside the tube. At this time, the operator can determine whether or not the self-expanding stent 2 has reached the bladder position by determining the condition of the urine backflow of the main tubular body 1. Therefore, the positioning operation can be performed by utilizing the pressure difference between the inside and the outside of the bladder, and when the main tube body 1 is observed to flow out of urine, the position of the far-end self-expanding body reaching the bladder can be judged, so that the operation is more convenient.

The principle of positioning by using the pressure difference between the inside and the outside of the bladder is as follows:

bladder urination is primarily a function of the urethral sphincter and detrusor muscle. When urine exists in the bladder, the pressure of the bladder is greater than the external pressure, but if the sphincter is closed like a valve, the urine cannot be discharged. If the sphincter valve opens, urine can be smoothly discharged out of the urethra due to the internal and external pressure difference between the bladder and the outside of the body. In most cases, the sphincter valve is opened and the detrusor starts to work (a larger pressure difference is produced), so that urine is smoothly discharged from the human body under the mutual cooperation of the sphincter valve and the detrusor.

The embodiment of the invention utilizes the pressure difference of the bladder under the condition of urine. When the product is inserted into the urethra to reach the bladder, the otherwise occluded sphincter is opened. Urine flows out along the urethra and when the operator sees the urine overflowed from the main body 1, he knows that the bladder has been reached.

At this time, the hard guide wire 3 is pulled to enable the distal end to be self-expanded, and when the main pipe body 1 is gently pulled to feel external resistance, the positioning can be determined to be completed.

After tissue ablation in the existing ablation operation, a doctor can insert the urethra of a patient into a catheter, and the catheter is beneficial to urination. Because of the characteristics of the pulse, whether the tissue is completely ablated cannot be immediately determined in the operation, the ablation effect can be generally seen only after 7 days of the operation, and if the ablation is not completely detected in the postoperative review, the patient also needs to perform the interventional operation again. The pulse ablation device provided by the embodiment of the invention can be directly used as a catheter, stays in the body for 7 days, and can be used for observing the tissue ablation metabolism condition through a doctor, and if the doctor needs to receive treatment again, the doctor can be directly connected with a pulse wiring to perform pulse emission treatment.

Specifically, the self-expanding stent 2 has a maximum diameter and a minimum length in the expanded state, the maximum diameter being larger than the diameter of the main tube body 1, and as shown in fig. 1, in the expanded state, both ends of the self-expanding stent 2 are folded to expand the middle portion, and the outline of the self-expanding stent 2 is substantially basket-shaped. The self-expanding stent 2 may also be of other configurations, such as spherical, egg-shaped, pumpkin-shaped, lantern-shaped, oval-shaped, etc.

Specifically, the self-expandable stent 2 has a minimum diameter and a maximum length in a contracted state, as shown in fig. 2, in which the distal end of the self-expandable stent 2 is supported by the stiff guide wire 3, both ends and the middle of the self-expandable stent 2 are folded inward, and the self-expandable stent 2 is in a straightened state or approximately in a straightened state, so that it is possible to conveniently reach a target position. When the pulse ablation device reaches the target position (namely the first opening reaches the bladder neck), the axial limit and the external force action on the hard guide wire 3 are removed, at this time, the hard guide wire 3 does not bear the self-expanding body forwards without external force, the self-expanding body can restore the original expanded shape, and the self-expanding body is fixed at the bladder neck, as shown in fig. 3.

The self-expandable stent 2 has a hollow structure inside, and the self-expandable stent 2 has an independent structure without the presence of a mandrel.

Because the urinary catheter needs to stay in the bladder for at least 7 days, many designs are positioned through the sacculus at present, or the urinary catheter is directly inserted, and the position that the far end urine of urinary catheter flows in has a certain distance with the bladder neck, when urine is accumulated in the bladder to the height that is higher than the far end urinary catheter stretches out from the sacculus, urine can only flow out. The portion of urine below the level at which the distal urinary catheter protrudes from the balloon remains lodged in the bladder and over time, the junction of the balloon and the bladder is susceptible to scaling. Meanwhile, due to long-term accumulation of urine, bladder inflammation is easy to occur, and the urethra is in long-term contact with the catheter, so that the urethra scaling is easy to produce inflammatory reaction. With continued reference to fig. 3, in the embodiment of the present invention, the proximal end of the self-expanding body is connected to the distal end of the main tube body 1, and the position of the bladder neck directly corresponds to the position of the first opening, so that urine 91 flows into the main tube body 1 through the first opening, thereby solving the problem that urine 91 is easily accumulated in the triangular region of the bladder 9 (bladder neck), and further being beneficial to avoiding scaling of the urine 91 and reducing the risk of bladder 9 and urinary complications. As shown in fig. 2, the first opening is preferably provided at the distal end of the main tubular body 1.

Preferably, the hard guide wire 3 is coaxially arranged in the main tube body 1, the hard guide wire 3 has the function of supporting and guiding the main tube body 1, and the hard guide wire 3 is arranged in the main tube body 1, so that the main tube body 1 can be more easily penetrated into the urethra, and the lower urinary obstruction section caused by diseases such as prostatic hyperplasia, urethral stricture and the like can smoothly slide into the bladder 9.

Preferably, with continued reference to fig. 1 and 2, a second opening is provided at the proximal end of the main tubular body 1, the distal end of the stiff guidewire 3 being capable of abutting the distal end of the self-expanding stent 2 via the first opening, extending partially or fully from the proximal end of the main tubular body 1 via the second opening. The hard guide wire 3 can move axially relative to the main pipe body 1 under the action of external force, so as to drive the self-expanding bracket 2 to expand or contract in the radial direction.

Preferably, the self-expanding stent 2 comprises a plurality of self-expanding elements 21 circumferentially arranged around the axis of the main tube body 1, as shown in fig. 1 and 4, with gaps formed between adjacent self-expanding elements 21 for passing liquid, the plurality of self-expanding elements 21 being enclosed to form a radially contractible and expandable structure. The proximal ends of the plurality of self-expanding elements 21 are connected to the distal end of the main tube body 1, the distal ends of the plurality of self-expanding elements 21 are tapered in the axial direction of the main tube body 1, and the diameters of the self-expanding elements 21 gradually increase from both ends to the middle.

The balloon is arranged on the existing catheter, and is inflated to be fixed at the bladder neck position in the bladder, so that the catheter cannot move, and the catheter is fixed. With continued reference to fig. 3, compared with the prior art, the pulse ablation device of the embodiment of the invention adopts the self-expanding stent 2 to replace the balloon, so as to reduce the bonding area between the self-expanding stent and the bladder 9, and facilitate reducing the occurrence of inflammation of the bladder 9 caused by long-term adhesion.

Preferably, the outer side wall of the main tube body 1 is provided with a groove to reduce the bonding area between the outer side wall of the main tube body 1 and the urethra, which is beneficial to reducing the occurrence of the urethra inflammation caused by long-term adhesion.

The self-expanding stent 2 shown in fig. 4 has four self-expanding elements 21 circumferentially disposed about the axis of the main tubular body 1, in other embodiments the number of self-expanding elements 21 may be three, five, six, seven, eight or any other suitable number. The self-expanding elements 21 may be preferably uniformly arranged in the circumferential direction as shown in fig. 4, or may be unevenly arranged.

Preferably, the self-expanding stent 2 is of symmetrical construction, and the plurality of sets of self-expanding elements 21 are symmetrically disposed about the axis of the main tubular body 1. Where "symmetrical" herein includes not only theoretically complete reference thereto but also approximate symmetry which tends to be symmetrical.

Optionally, the distal ends of the self-expanding stent 2 are comprised of self-expanding elements 21 interconnected.

Alternatively, the self-expanding element 21 is made of a shape memory material. The shape memory material may be a shape memory alloy or a polymer elastomer, preferably a memory silicone material. The self-expanding element 21 is made of silica gel, so that the self-expanding stent 2 can enter the urethra more flexibly to reach the position of the bladder, the urethra is prevented from being damaged, and the comfort level of a patient is improved.

Optionally, the expansion element is preformed and then secured to the expansion bracket by fastening.

Preferably, the distal end of the self-expanding stent 2 is also provided with a positioning structure; the positioning structure is provided with a limiting part and a connecting part, wherein the limiting part is used for limiting the distal end of the hard guide wire 3 abutting against the limiting part in the radial direction, the connecting part is used for being connected with the distal end of the self-expanding element 21, and the radial dimension of the connecting part is not greater than the radial dimension of the middle part of the self-expanding bracket 2.

Preferably, the proximal end of the stiff guidewire 3 protrudes from the proximal end of the main tubular body 1. The proximal end of the hard guide wire 3 is pulled to drive the hard guide wire 3 to move from the distal end to the proximal end, and the proximal end of the hard guide wire 3 is pushed to drive the hard guide wire 3 to move from the proximal end to the distal end, so that the structure is simple and the operation is convenient.

Preferably, the self-expanding stent further comprises an axial limiting structure 5, wherein the axial limiting structure 5 is used for limiting the relative position of the hard guide wire 3 and the main tube body 1 in the axial direction of the main tube body 1, so that the self-expanding stent 2 is in a contracted state, and the self-expanding stent is convenient to operate without manually pressing and limiting.

Further, the axial limiting structure 5 includes a first mating limiting portion 51 and a second mating limiting portion 52, the first mating limiting portion 51 is disposed at a proximal end of the hard guide wire 3, the second mating limiting portion 52 is disposed at a proximal end of the main tube body 1, and the hard guide wire 3 and the main tube body 1 can be mated and limited by the first mating limiting portion 51 and the second mating limiting portion 52. Illustratively, the first mating stop 51 may be an internal thread and the second mating stop 52 may be an external thread; illustratively, the first mating limiting portion 51 may be a limiting bump, and the second mating limiting portion 52 may be a limiting groove; the axial limiting structure 5 may also be a bayonet device, and other structures capable of limiting the rigid guide wire 3 and the main tube body 1 in the axial direction may also be used herein.

Specifically, a liquid level observation portion is provided on the main tube body 1, the distal end of the liquid level observation portion is close to the proximal end of the ablation electrode 4, the proximal end of the liquid level observation portion is close to the proximal end of the main tube body 1, and the liquid level observation portion is used for observing the liquid level in the main tube body 1. Optionally, the liquid level observation part covers at least a partial area of the proximal end of the main tube body 1, which is a light-transmitting area; preferably, the light-transmitting region may be a transparent region, a translucent region, or the like.

In one embodiment, a plurality of ablation electrodes 4 are spaced axially along the main tubular body 1 so as to accommodate ablation targets of different locations and sizes. Illustratively, a first ablation electrode 4 is placed a first predetermined distance from the proximal end of the self-expanding body, followed by placement of one ablation electrode 4 every second predetermined distance. The first preset distance may be 2-8mm, and exemplary, the first preset distance is 2mm, 5mm, 8mm; the second preset distance may be 2-8mm, and exemplary, the first preset distance is 2mm, 5mm, 8mm; it should be noted that, the values of the first preset distance and the second preset distance may be adjusted according to actual needs, which is not limited in this embodiment.

The electrode may be a ring electrode, a sheet electrode, a dot electrode, a spherical electrode, or the like, and the present embodiment is not particularly limited.

In one embodiment, as shown in fig. 4 and 5, the pulse ablation device further comprises at least one ablation controller 6, the at least one ablation controller 6 being disposed outside the main tubular body 1, the ablation electrode 4 being electrically connected to the electrode pins. With continued reference to fig. 5, when it is determined that the product reaches the target position, i.e. the first opening is located at the bladder neck, the position range of the ablation tissue of the prostate 8 is positioned through the positions of the prostate 8 and the bladder 9, and the corresponding ablation electrode 4 is controlled by the corresponding ablation controller 6 to perform pulse ablation.

In one embodiment, the pulse ablation device further comprises a branch pipe body 7, one end of the branch pipe body 7 is communicated with the side wall of the main pipe body 1, and the other end of the branch pipe body 7 is provided with an electrode pin. As shown in fig. 5, the electrodes are finally branched to the branch pipe body 7 along the main pipe body 1, and electrode pins provided on the branch pipe body 7 are respectively inserted at corresponding positions on the controller through wires.

In the foregoing embodiments, the descriptions of the embodiments are emphasized, and for parts of one embodiment that are not described in detail, reference may be made to related descriptions of other embodiments.

The embodiment of the pulse ablation device provided by the embodiment of the invention can judge the arrival position of the product by utilizing the pressure difference between the inside and outside of the bladder, and then position the position range of the prostate ablation tissue by the position of the prostate and the bladder, so that the accurate positioning ablation can be realized without using an external image product, the electromagnetic interference caused by the pulse generation is avoided, and the safety and the effectiveness of the operation are improved. Meanwhile, the device can be directly used as a catheter, stays for 7 days in the body, can be directly connected with a pulse wiring for pulse emission treatment if the treatment is required to be received again, and does not need to be intervened again.

The foregoing is only illustrative of the present invention and is not to be construed as limiting thereof, but rather as various modifications, equivalent arrangements, improvements, etc., within the spirit and principles of the present invention.

The foregoing is merely a preferred embodiment of the present invention, and it is apparent to those skilled in the art that the present invention is not limited to the details of the above-described exemplary embodiment, but may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.

Claims (11)

1. A pulse ablation device, which is characterized by comprising a main tube body (1), a self-expanding bracket (2), a hard guide wire (3), at least one ablation electrode (4) and at least one electrode pin;

the distal end of the main pipe body (1) is connected with the proximal end of the self-expanding bracket (2), a first opening is arranged at the distal end of the main pipe body (1), a second opening is arranged at the proximal end of the main pipe body (1), and the second opening is communicated with the first opening; the main pipe body (1) is internally penetrated with the hard guide wire (3), the distal end of the hard guide wire (3) can be abutted against the distal end of the self-expanding stent (2), the self-expanding stent (2) can be driven by the hard guide wire (3) to be switched from an expanding state to a contracting state, and the self-expanding stent can be automatically switched from the contracting state to the expanding state when the hard guide wire (3) is not driven; the self-expanding stent (2) has a maximum diameter in the expanded state and a minimum diameter in the contracted state, the maximum diameter being greater than the diameter of the main tubular body (1);

the at least one ablation electrode (4) is arranged within the main tubular body (1) and near the distal end of the main tubular body (1), the ablation electrode (4) being electrically connected to the electrode pins.

2. The pulse ablation device according to claim 1, wherein the self-expanding stent (2) comprises a plurality of self-expanding elements (21) arranged circumferentially around the axis of the main tube body (1), the proximal ends of the plurality of self-expanding elements (21) are connected to the distal ends of the main tube body (1), the distal ends of the plurality of self-expanding elements (21) are tapered toward the axis of the main tube body (1), and the diameter of the self-expanding elements (21) gradually increases from both ends toward the middle.

3. The pulse ablation device according to claim 2, characterized in that the self-expanding element (21) is made of a shape memory material.

4. A pulse ablation device according to claim 3, characterized in that the self-expanding element (21) is made of a memory silicone material.

5. The device according to claim 1, characterized in that the proximal end of the stiff wire (3) protrudes from the proximal end of the main tubular body (1).

6. The pulse ablation device according to claim 5, further comprising an axial limit structure (5), the axial limit structure (5) being adapted to define the relative position of the stiff wire (3) and the main tube (1) in an axial direction of the main tube (1).

7. The device according to claim 6, characterized in that the axial limit structure (5) comprises a first mating limit portion (51) and a second mating limit portion (52), the first mating limit portion (51) being arranged at the proximal end of the stiff guide wire (3), the second mating limit portion (52) being arranged at the proximal end of the main tube body (1), the stiff guide wire (3) and the main tube body (1) being capable of being mated and limited by the first mating limit portion (51) and the second mating limit portion (52).

8. The pulse ablation device according to claim 1, characterized in that the main tube body (1) is provided with a fluid level viewing portion, the distal end of which is close to the proximal end of the ablation electrode, the proximal end of which is close to the proximal end of the main tube body (1), the fluid level viewing portion being adapted to view the fluid level within the main tube body (1).

9. The pulse ablation device according to claim 1, characterized in that a plurality of said ablation electrodes (4) are arranged at intervals along the axial direction of said main tubular body (1).

10. The pulse ablation device according to claim 1, further comprising at least one ablation controller (6), the at least one ablation controller (6) being arranged outside the main tubular body (1), the ablation electrode (4) being electrically connected to the electrode pin.

11. The pulse ablation device according to claim 1, further comprising a branch pipe body (7), one end of the branch pipe body (7) being in communication with a side wall of the main pipe body (1), the other end of the branch pipe body (7) being provided with the electrode pin.

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