CN116087193A - Method for predicting efficacy product to fade open acne by using integrated device system - Google Patents
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
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Abstract
The invention relates to the technical field of cosmetic evaluation, in particular to an IPC A61B5, and more particularly relates to a method for fading open comedones by using an integrated device system to predict efficacy products. The invention utilizes a visual and quantitative integrated device system, adopts artificial sebum, and rapidly predicts the efficacy of the product in fading open acne by controlling the ambient temperature and humidity, shooting record, dyeing, sebum light transmittance and sebum dissolution metering. By adopting the detection method, the damage of the functional product to the skin of the human body is reduced, the detection period is shortened, the repeatability is very high, and the accuracy and the scientificity of the evaluation method are improved.
Description
Technical Field
The invention relates to the technical field of cosmetic evaluation, in particular to an IPC A61B5, and more particularly relates to a method for fading open comedones by using an integrated device system to predict efficacy products.
Background
Open acne, commonly called "blackhead", is a hardened grease obstruction, mainly consisting of sebum, cell debris and bacteria, which is formed by the fact that the surface layer of sebum blocking pores is directly exposed to the outside and is contacted with dust in the air, and the obstruction is a "plug" sample consisting of sebum, cell debris and bacteria. It is characterized by the black spots in the obviously enlarged pores, the shape after extrusion is like a bug, and the top end is blackened. Blackheads are a physical skin disease and have little influence on health, but blackheads are required by Chinese lovers because blackheads grow, pores become large and beautifying is influenced.
A large number of blackhead removing products in the market are emerging, but the efficacy of the blackhead removing products in the market is uneven, at present, the human efficacy evaluation method for the blackhead removing cosmetics is an expert counting method, the effectiveness of the products is evaluated by recording the number of blackhead acnes before and after the products are used, but the expert technology method is relatively subjective, takes relatively long time and is high in cost, and therefore, a method for objectively and rapidly evaluating the efficacy of the blackhead removing products needs to be developed.
The prior patent CN202111066006 discloses a method for evaluating the human body efficacy of a blackhead-removing cosmetic, which adopts shooting of face images of volunteers before and after using products to be tested, and can analyze blackhead-removing effect of blackhead-removing products through systematic analysis, thus having good repeatability and being similar to an expert counting method. However, the method must use blackhead removing products on the faces of volunteers, some blackhead removing products may damage the skin of the faces, the skin is further damaged, and the use period is long, and the method only evaluates the efficacy of the products before and after use, and does not consider the performance of the efficacy of the products in the use process, namely the condition of blackhead dissolution.
Disclosure of Invention
To solve the problems in the prior art, a first aspect of the present invention provides a method for fading open comedones using an integrated device system to predict efficacy product, comprising the steps of:
the integrated device system is utilized to set shooting environment for observing the sample bottle, to observe injection of efficacy products in the sample bottle, to shoot video, to measure and analyze whiteness of grease and height of each layer of grease after sebum dissolution and balance.
Preferably, the integrated device system comprises a constant temperature and humidity control system, a camera system, a sample processing system, a detection system, a data recording and analysis system.
Preferably, the camera system comprises a wire collecting display module and a track module. The line display and winding module comprises two cameras for shooting an observation sample bottle; the track module can control the movement of the camera and determine proper distance shooting.
Preferably, the sample processing system comprises a sample injection module, a sample placement module and a light module. The sample injection module comprises an automatic sample injection device and can inject the functional product into an observation sample bottle; the sample placing module is used as a sample placing platform; the light module comprises a lamp panel and a curtain, and the observation sample bottle is placed in a proper shooting environment.
Preferably, the detection system comprises a scanning module and a height measurement module. The scanning module is used for measuring and observing whiteness of grease after sebum dissolution in the sample bottle is balanced; the height measurement module is used for measuring the height of each layer of grease after sebum dissolution and balance in the sample bottle.
Preferably, the data recording and analyzing system records and analyzes the data shot by the shooting system, the whiteness of the detected grease and the height of each layer of grease by the detecting system.
In some preferred schemes, the constant temperature and humidity system is firstly opened, the temperature and humidity in the system are controlled, then the camera system is arranged, the position of a camera in the control track module is fixed and the camera in the display and collection module, the sample processing module is used for injecting functional products into the observation sample bottle, the observation sample bottle is placed on the sample placing platform, and then the light module is arranged, so that the observation sample bottle is placed in a proper shooting environment. The whiteness of the grease and the height of each layer of grease after the sebum dissolution balance are detected and observed by the detection system, and the data recording and analyzing system records and analyzes the data shot by the shooting system and the whiteness of the grease and the height of each layer of grease detected by the detection system.
Preferably, the method for predicting the efficacy product to lighten open acne by using the integrated device system specifically comprises the following steps:
s1: opening a constant temperature and humidity system;
s2: sample processing system, camera system processing: extracting the functional product, injecting the functional product into an observation sample bottle, wherein the observation sample bottle contains artificial sebum dyed by pigment, placing the observation sample bottle on a lifting frame, adjusting the height, and shooting a video by arranging observation equipment;
s3: sample processing system, camera system processing: pumping the functional product dyed by the pigment into an observation sample bottle, wherein the observation sample bottle contains artificial sebum, placing the observation sample bottle on a lifting frame, adjusting the height, and shooting a video by virtue of observation equipment;
s4: and (3) processing by a detection system scanning module: scanning whiteness of sebum after the sebum in S2 is dissolved out and balanced by adopting a transmission light wave band scanning device, and simulating the condition of sebum dissolution after nose sebum of a human body contacts with an efficacy product;
s5: the detection system height measurement module processes: measuring and observing the thickness of sebum at the uppermost layer of the sample bottle by using a height ruler after the sebum dissolution in the S3 reaches balance;
s6: data recording and analysis system processes: recording and analyzing.
Preferably, the volume ratio of the dyed artificial sebum in the observation sample bottle to the observation sample bottle in the step S2 is (0.5-2.5): 20, a step of; further preferred is 1:20.
preferably, the amount of sebum stained in the sample bottle observed in S2 is 1mL.
Preferably, the pigment of the sample bottle observed in S2 is an oil-soluble pigment.
Preferably, the color of the oil-soluble pigment comprises any one of purple, blue, yellow, green, orange and pink; further preferably, the oil-soluble pigment is purple in color
Preferably, the specific process of dyeing the artificial sebum with the pigment in the step S2 is as follows: heating artificial sebum to 75-80 deg.c, adding oil soluble pigment when the artificial sebum is in full melt flow state, stirring with glass rod, and cooling in observation sample bottle.
Preferably, the ratio of the artificial sebum to the oil-soluble pigment in the S3 is 1 to 1.2mL:0.05mL; further preferably, 1mL:0.05mL.
Preferably, the artificial sebum in S2 and S3 is purchased from Dongguan City, model CF-007, inc.
In the invention, the artificial sebum meeting the ASTM American society for testing and materials (American Society of Testing Materials) standard is adopted, so that the accuracy of the detection method is improved, and the damage of the blackhead removing product to human skin is reduced. The inventor discovers that when the artificial sebum of the invention is adopted, the novel simulated test agent which is developed by scientific research and strictly according to the components of the human true sebum is an artificial sebum membrane which is prepared manually, the components of the artificial sebum membrane are close to 99.9% of the human dermis fat, the state of human skin can be almost simulated, and experiments are carried out on the artificial sebum, so that the state of the blackhead removing product for the real skin is perfectly reproduced, and the damage to the human skin is reduced.
Preferably, the functional product has the function of removing blackheads.
Preferably, the functional product is blackhead filtrate.
Preferably, the ratio of the functional product to the pigment in the S3 is 7-7.2 mL:0.15mL; further preferably, 7mL:0.05mL.
Preferably, the blackhead filtrate is purchased from crape myrtle cosmetics (su state) limited.
Preferably, the pigment in S3 is a water-soluble pigment;
preferably, the water-soluble pigment color comprises any one of red, blue, orange, purple and green; further preferably, it is red.
In the invention, purple oil-soluble pigment is selected for observation, and red water-soluble pigment is selected for observation of sebum thickness of sebum accumulated on the upper layer of the sample bottle after sebum dissolution balance, so that the accuracy of detecting the initial sebum dissolution rate and the accuracy of measurement can be improved. The inventor finds that when products such as blackhead liquid and the like are added into artificial sebum, sebum gradually dissolves out from the surface of the artificial sebum, the sebum is appeared in a sample bottle, the dissolution effect is not obvious when pigment is not added, the visualization and identification degree of the dissolution effect of grease are improved when pigment is added, and when purple oil-soluble pigment is added, the dissolution of sebum in the preliminary stage appears more obvious, so that the dissolution rate of sebum in the preliminary stage is estimated according to a photographed video. When judging the final total sebum elution amount, the inventor unexpectedly found that the red water-soluble pigment is selected to improve the boundary between the upper layer grease and other liquid of the sample bottle, and the inventor speculates that the water-soluble pigment does not dye the grease, so that the eluted grease reaches the elution balance after standing for a period of time, can be accumulated on the upper layer of the sample bottle, forms obvious layering, can better distinguish the thickness of the upper layer grease and is easy to measure.
Preferably, the observation device is two kinds of observation devices, and the two kinds of observation modes are matched.
Preferably, the observing mode is to use a tube lens group for an infinite objective lens to be matched with a tele objective lens, to be matched with a camera for imaging, to observe sebum dissolving rate in a micro-distance mode, and to shoot local high-definition dynamic video.
Preferably, the second observation mode is that a small tripod is matched with a camera, sebum dissolution is integrally observed, and an integral global high-definition dynamic video is shot.
According to the invention, through arranging an integrated system space and matching the tube lens group for the infinite objective lens with the long-focus objective lens and the small tripod to match with the camera, the objectivity of sebum dissolution phenomenon is improved, the influence of a plurality of subjective factors and external factors is reduced, the accuracy and sensitivity of the detection method for evaluating the efficacy product are improved, and the test period is reduced. The inventor finds that the camera is matched in the integrated system space, so that the external light change is reduced, and the sensitivity of a tester to the color change is improved. At the same time, the sebum remover is stable at a temperature, and the sebum is prevented from being dissolved out differently due to different environmental temperatures. The whole integrated device system is matched with a precise instrument, so that the accuracy and the sensitivity of instrument measurement are improved while the damage of the instrument is reduced. The detection method of the invention does not need to use the functional product on the skin of volunteers for a long time, and can measure the effect of the functional product in a short time.
Advantageous effects
1. In the invention, the artificial sebum meeting the ASTM American society for testing and materials (American Society of Testing Materials) standard is adopted, so that the accuracy of the detection method is improved, and the damage of the blackhead removing product to human skin is reduced.
2. According to the invention, the purple oil-soluble pigment is selected to observe the sebum dissolution rate, and the red water-soluble pigment is selected to observe the sebum thickness of the upper layer of the sample bottle after sebum dissolution balance, so that the accuracy of detecting the sebum dissolution rate in the initial stage and the measurement accuracy of the detection method can be improved, and the test period is reduced.
3. According to the invention, through arranging an integrated system space and matching the tube lens group for the infinite objective lens with the long-focus objective lens and the small tripod to match with the camera, the objectivity of sebum dissolution phenomenon is improved, the influence of a plurality of subjective factors and external factors is reduced, and the accuracy and sensitivity of the detection method for evaluating the efficacy product are improved.
4. The invention provides an in-vitro sebum dissolution test method, which takes artificial sebum as a tested object, avoids directly using a functional product on the face, and has the advantages of high test speed, short period and high repeatability.
5. The invention utilizes a visual and quantitative integrated device system, adopts artificial sebum, and rapidly predicts the efficacy of the product in fading open acne by controlling the environmental temperature and humidity, shooting record, sebum dyeing, sebum light transmittance and sebum dissolution metering.
Drawings
FIG. 1 is a schematic diagram of the integrated device system in embodiment 1;
FIG. 2 is a flow chart showing the integrated device system in embodiment 1;
FIG. 3 is a screenshot of the local video taken using the method of examples 1-5, wherein 0min, 1min, 3min, 5min, 10min, 15 min;
FIG. 4 is a screenshot of taking global video of example 1, examples 6-7, wherein 0min, 1min, 3min, 5min, 10min, 15 min;
FIG. 5 is a photograph scenery in integrated system space;
FIG. 6 is a photograph scenery map in integrated system space;
fig. 7 is a sebum stratification using the method of example 1.
Detailed Description
Example 1
The first aspect of the present embodiment provides a method for predicting efficacy product desalination of open comedones using an integrated device system, comprising the steps of:
the integrated device system is utilized to set shooting environment for observing the sample bottle, to observe injection of efficacy products in the sample bottle, to shoot video, to measure and analyze whiteness of grease and height of each layer of grease after sebum dissolution and balance.
The integrated device system comprises a constant temperature and constant humidity control system, a camera system, a sample processing system, a detection system and a data recording and analyzing system.
The camera shooting system comprises a wire collecting display module and a track module. The line display and winding module comprises two cameras for shooting an observation sample bottle; the track module can control the movement of the camera and determine proper distance shooting.
The sample processing system comprises a sample injection module, a sample placement module and a lamplight module. The sample injection module comprises an automatic sample injection device and can inject the functional product into an observation sample bottle; the sample placing module is used as a sample placing platform; the light module comprises a lamp panel and a curtain, and the observation sample bottle is placed in a proper shooting environment.
The detection system comprises a scanning module and a height measurement module. The scanning module is used for measuring and observing whiteness of grease after sebum dissolution in the sample bottle is balanced; the height measurement module is used for measuring the height of each layer of grease after sebum dissolution and balance in the sample bottle.
The data recording and analyzing system records and analyzes the data shot by the shooting system, the whiteness of the detected grease and the height of each layer of grease by the detecting system.
Firstly, a constant temperature and humidity system is opened, the temperature and humidity in the system are controlled, a camera system is set, the position of a camera in a control track module is fixed, an effect product is injected into an observation sample bottle through a sample processing module, the observation sample bottle is placed on a sample placing platform, and a light module is set, so that the observation sample bottle is placed in a proper shooting environment. The whiteness of the grease and the height of each layer of grease after the sebum dissolution balance are detected and observed by the detection system, and the data recording and analyzing system records and analyzes the data shot by the shooting system and the whiteness of the grease and the height of each layer of grease detected by the detection system. See fig. 1 and 2.
The method for predicting efficacy product to fade open acne by using integrated device system comprises the following steps of
S1: opening a constant temperature and humidity system;
s2: sample processing system, camera system processing: taking 1mL of artificial sebum, heating the artificial sebum to 75-80 ℃, adding the purple oil-soluble pigment when the artificial sebum is in a full-melt flowing state, uniformly stirring the mixture by using a glass rod, and filling the mixture into an observation sample bottle for standing and cooling. 7mL were drawn by the autosampler: injecting 0.15mL of black head derived liquid into an observation sample bottle, placing the observation sample bottle on a lifting frame in the observation sample bottle, configuring a white light condensing plate on the lifting frame, adjusting the height of a back curtain which is a white curtain, and configuring two observation modes, wherein one observation mode is to shoot a local high-definition dynamic video (shown in figure 4) by using a pipe lens group for an infinity objective to be matched with a tele objective and a camera for imaging, observing sebum dissolution rate in a micro-distance mode, and the other observation mode is to shoot a whole high-definition dynamic video (shown in figure 5) by using a small tripod to be matched with a camera for integrally observing sebum dissolution condition; respectively storing photos at 0min, 1min, 3min, 5min, 10min and 15min, and completing video recording for 15 min; the results are shown in FIG. 3.
S3: sample processing system, camera system processing: extracting 7mL of black head derived liquid dyed by red water-soluble pigment by an automatic sampler, injecting the black head derived liquid into an artificial sebum observing sample bottle containing 1mL, placing the observing sample bottle on a lifting frame, configuring a white light condensing plate on the lifting frame, setting a back curtain as a white curtain, adjusting the height, and configuring two observing modes, wherein one mode is to use a tube lens group for an infinite objective lens to be matched with a tele objective lens to form images by matching with a camera, observing sebum dissolving rate at a micro distance, shooting a local high-definition dynamic video (shown in figure 4), and the other mode is to use a small tripod to be matched with a camera to integrally observe sebum dissolving condition, and shooting a whole high-definition dynamic video (shown in figure 6); respectively storing photos at 0min, 1min, 3min, 5min, 10min and 15min, and completing video recording for 15 min; the results are shown in FIG. 4.
S4: and (3) processing by a detection system scanning module: scanning the whiteness of the sebum after the sebum dissolution balance of S2 by adopting a transmission light wave band scanning device, and simulating the condition of the sebum dissolution after the nose sebum of a human body contacts with the functional product;
s5: the detection system height measurement module processes: measuring and observing the thickness of sebum at the uppermost layer of the sample bottle by using a height ruler after the sebum dissolution in the S3 reaches balance, simulating the quantity of sebum which can be scraped by the nose of a human body, and evaluating the quantity of sebum dissolution of the blackhead filtrate; (as shown in fig. 7).
S6: data recording and analysis system processes: recording and analyzing.
The blackhead filtrate was purchased from Mirabilitum cosmetics (Suzhou).
Example 2
The specific implementation method of example 2 is the same as example 1, except that S2: the pigment added in the blackhead filtrate in a dropwise manner is blue oil-soluble pigment. The photographs were kept at 0min, 1min, 3min, 5min, 10min, and 15min, respectively, and the results are shown in FIG. 3.
Example 3
The specific implementation method of example 3 is the same as that of example 1, except that S2: the pigment added dropwise into the blackhead filtrate is yellow oil-soluble pigment. The photographs were kept at 0min, 1min, 3min, 5min, 10min, and 15min, respectively, and the results are shown in FIG. 3.
Example 4
The specific implementation method of example 4 is the same as that of example 1, except that S2: the pigment added in the blackhead filtrate in a dropwise manner is pink oil-soluble pigment. The photographs were kept at 0min, 1min, 3min, 5min, 10min, and 15min, respectively, and the results are shown in FIG. 3.
Example 5
The specific implementation method of example 5 is the same as that of example 1, except that S2: the pigment added in the blackhead filtrate in a dropwise manner is green oil-soluble pigment. The photographs were kept at 0min, 1min, 3min, 5min, 10min, and 15min, respectively, and the results are shown in FIG. 3.
Example 6
The specific implementation method of example 6 is the same as that of example 1, except that S2: the pigment added in the blackhead filtrate in a dropwise manner is pink water-soluble pigment. The photographs were kept at 0min, 1min, 3min, 5min, 10min, and 15min, respectively, and the results are shown in FIG. 4.
Example 7
The specific implementation method of example 7 is the same as that of example 1, except that S2: the pigment added dropwise into the black head filtrate is cyan water-soluble pigment. The photographs were kept at 0min, 1min, 3min, 5min, 10min, and 15min, respectively, and the results are shown in FIG. 4.
Performance testing
1. The efficacy materials with concentrations of 5%, 10%, 20% and 30% were prepared into blackhead filtrate (the blackhead filtrate was purchased from crape myrtle company), and the dissolution of sebum, the dissolution amount and the dissolution whiteness were measured by the method used in example 1; the results obtained are shown in Table 1; as can be seen from table 1, the formulation with an addition of 30% gave the best dissolution effect on artificial sebum;
2. using expert counting method to verify the four concentration formulas on human body, and testing by 20 volunteers respectively; volunteers firstly evaluate nose blackheads by visual inspection by an expert before testing, count the blackheads, apply the nose heads by using a hot towel after face cleaning, attach blackhead filtrate on a biological fiber membrane to apply the nose heads, take off the biological fiber membrane after waiting for 15 minutes, scrape the blackheads by using cotton sticks, count the number of the nose blackheads after cleaning, and carry out relevant statistical analysis on the result data after the test is finished, and the results are shown in Table 2. From the results, the results of sebum in vitro are related to the results of expert counting.
TABLE 1
TABLE 2
Claims (10)
1. A method for lightening open comedones using an integrated device system to predict efficacy of a product, comprising the steps of:
the integrated device system is utilized to set shooting environment for observing the sample bottle, to observe injection of efficacy products in the sample bottle, to shoot video, to measure and analyze whiteness of grease and height of each layer of grease after sebum dissolution and balance.
2. The method for predicting efficacy product in the treatment of open comedones using an integrated device system of claim 1, wherein the integrated device system comprises a constant temperature and humidity control system, a camera system, a sample processing system, a detection system, a data recording and analysis system.
3. The method for using an integrated device system to predict an efficacy product for the desalination of open comedones according to claim 1, wherein the method for using an integrated device system to predict an efficacy product for the desalination of open comedones specifically comprises:
s1: opening a constant temperature and humidity system;
s2: sample processing system, camera system processing: extracting the functional product, injecting the functional product into an observation sample bottle, wherein the observation sample bottle contains artificial sebum dyed by pigment, placing the observation sample bottle on a lifting frame, adjusting the height, and shooting a video by arranging observation equipment;
s3: sample processing system, camera system processing: pumping the functional product dyed by the pigment into an observation sample bottle, wherein the observation sample bottle contains artificial sebum, placing the observation sample bottle on a lifting frame, adjusting the height, and shooting a video by virtue of observation equipment;
s4: and (3) processing by a detection system scanning module: scanning whiteness of sebum after the sebum in S2 is dissolved out and balanced by adopting a transmission light wave band scanning device, and simulating the condition of sebum dissolution after nose sebum of a human body contacts with an efficacy product;
s5: the detection system height measurement module processes: measuring and observing the thickness of sebum at the uppermost layer of the sample bottle by using a height ruler after the sebum dissolution in the S3 reaches balance;
s6: data recording and analysis system processes: recording and analyzing.
4. The method for lightening open comedones using an integrated device system predictive efficacy product as claimed in claim 3 wherein the color of the sight glass in S2 is an oil-soluble color; the color of the oil-soluble pigment comprises any one of purple, blue, yellow, green, orange and pink.
5. The method for lightening open comedones using an integrated device system predictive efficacy product of claim 3 wherein the colorant in S3 is a water soluble colorant; the water-soluble pigment color comprises any one of red, blue, orange, purple and green.
6. The method for fading open comedones using the integrated device system to predict efficacy product according to claim 3, wherein the specific process of dyeing artificial sebum with pigment in S2 is: heating artificial sebum to 75-80 deg.c, adding oil soluble pigment when the artificial sebum is in full melt flow state, stirring with glass rod, and cooling in observation sample bottle.
7. The method for lightening open comedones using an integrated device system of claim 3 wherein the functional product functions as a blackhead product.
8. The method for lightening open comedones using an integrated device system to predict efficacy product as claimed in claim 3 wherein the viewing device is two viewing devices matching both global and microscopic viewing modes.
9. The method for fading open comedones by using the integrated device system according to claim 8, wherein one of the observation modes is to use a tube lens set for an infinity objective lens to be matched with a tele objective lens, to be matched with a camera for imaging, to observe sebum dissolution rate at a micro distance, and to shoot local high-definition dynamic video; the second observation mode is that a small tripod is matched with a camera, sebum dissolution is observed integrally, and an overall global high-definition dynamic video is shot.
10. Use of a method for lightening open comedones using an integrated device system according to any one of claims 1 to 9, for evaluating the efficacy of a blackhead removal product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310107230.7A CN116087193A (en) | 2023-02-13 | 2023-02-13 | Method for predicting efficacy product to fade open acne by using integrated device system |
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| CN202310107230.7A CN116087193A (en) | 2023-02-13 | 2023-02-13 | Method for predicting efficacy product to fade open acne by using integrated device system |
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| JP2012006851A (en) * | 2010-06-23 | 2012-01-12 | Kao Corp | Sebum removing sheet in pore |
| CN104873197A (en) * | 2014-02-28 | 2015-09-02 | 花王株式会社 | Skin evaluation method, skin care product or cosmetic recommendation method |
| CN110161027A (en) * | 2019-03-06 | 2019-08-23 | 上海商路网络科技有限公司 | A kind of cosmetic industry evaluation method based on image analysis |
| CN113854961A (en) * | 2021-09-13 | 2021-12-31 | 珀莱雅化妆品股份有限公司 | Evaluation method for human body efficacy of blackhead removing cosmetic |
| CN115200963A (en) * | 2022-07-15 | 2022-10-18 | 重庆医科大学附属儿童医院 | Oil red O staining solution and oil red O staining method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2012006851A (en) * | 2010-06-23 | 2012-01-12 | Kao Corp | Sebum removing sheet in pore |
| CN104873197A (en) * | 2014-02-28 | 2015-09-02 | 花王株式会社 | Skin evaluation method, skin care product or cosmetic recommendation method |
| CN110161027A (en) * | 2019-03-06 | 2019-08-23 | 上海商路网络科技有限公司 | A kind of cosmetic industry evaluation method based on image analysis |
| CN113854961A (en) * | 2021-09-13 | 2021-12-31 | 珀莱雅化妆品股份有限公司 | Evaluation method for human body efficacy of blackhead removing cosmetic |
| CN115200963A (en) * | 2022-07-15 | 2022-10-18 | 重庆医科大学附属儿童医院 | Oil red O staining solution and oil red O staining method |
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