CN116077759B - Radiopharmaceutical injection device and method of operation thereof - Google Patents
Radiopharmaceutical injection device and method of operation thereof Download PDFInfo
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- CN116077759B CN116077759B CN202211510304.3A CN202211510304A CN116077759B CN 116077759 B CN116077759 B CN 116077759B CN 202211510304 A CN202211510304 A CN 202211510304A CN 116077759 B CN116077759 B CN 116077759B
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- 239000012217 radiopharmaceutical Substances 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title abstract description 14
- 239000007924 injection Substances 0.000 claims abstract description 157
- 238000002347 injection Methods 0.000 claims abstract description 157
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 20
- 229940121896 radiopharmaceutical Drugs 0.000 claims description 30
- 230000002799 radiopharmaceutical effect Effects 0.000 claims description 30
- 230000001681 protective effect Effects 0.000 claims description 18
- 230000002439 hemostatic effect Effects 0.000 claims description 16
- 230000000903 blocking effect Effects 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 9
- 210000003462 vein Anatomy 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 210000001503 joint Anatomy 0.000 claims description 2
- 238000004891 communication Methods 0.000 abstract description 16
- 229940079593 drug Drugs 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 9
- 230000002285 radioactive effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000003384 imaging method Methods 0.000 description 6
- 230000005855 radiation Effects 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 206010073306 Exposure to radiation Diseases 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000004712 air sac Anatomy 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/132—Tourniquets
- A61B17/135—Tourniquets inflatable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for haemostasis, for prevention of bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The embodiment of the application provides a radiopharmaceutical injection device and a working method thereof, wherein the radiopharmaceutical injection device comprises: a base, an injection needle, a syringe assembly, and a push assembly; the injection needle is arranged on the base; the syringe assembly is arranged on the base and can move along a first direction relative to the base, the syringe assembly is provided with a first position and a second position, the syringe assembly comprises a first syringe and a second syringe, physiological saline is arranged in the first syringe, and a radioactive drug is arranged in the second syringe; the pushing component is arranged on the base, and can move along a second direction relative to the base, the first direction is perpendicular to the second direction, wherein the first injector is communicated with the injection needle under the condition that the injector component is positioned at a first position, and the pushing component moves along the second direction and pushes the first injector; with the syringe assembly in the second position, the second syringe is in communication with the injection needle, and the pushing assembly moves in the second direction and pushes the second syringe.
Description
Technical Field
The application belongs to the technical field of medical appliances, and particularly relates to a radioactive drug injection device and a working method thereof.
Background
In the image diagnosis of radionuclides, a dynamic imaging technology is a common diagnosis technology, for example, kidney functions are diagnosed by using a kidney dynamic imaging technology, osteomyelitis is diagnosed by using a three-phase bone imaging technology, and cerebrovascular diseases are all very important to be diagnosed by using a cerebrovascular dynamic imaging technology. Dynamic imaging techniques, however, typically require intravenous bolus injection of the radionuclide using a bolus injection method, where a high concentration, small volume of radiopharmaceutical is injected into the vein at high pressure, causing the radiopharmaceutical to enter the organ to be examined in a highly aggregated state. This method places higher demands on manual injection. The failure rate of the existing artificial projectile injection is about 5%, and the poor rate is about 10%. Bolus injection failure is a pain problem that currently exists and has no good solution, particularly in renal dynamic imaging, poor bolus injection quality will directly result in false degradation of Glomerular Filtration Rate (GFR), and thus image diagnosis result accuracy. Bolus injection depends on the operating experience of the doctor, and if bolus injection fails, the patient cannot continue with subsequent image shots on the same day, and even experienced doctors still bear a great psychological burden. In terms of injection safety, the radiation protection afforded by the syringe shield is only about 46% due to the requisite bare interface.
Disclosure of Invention
The embodiment of the application provides a radioactive drug injection device and a working method thereof, which are used for solving the problems of the failure risk of a projectile and radiation injury of radioactive drugs caused by instability of manual injection.
Embodiments of the first aspect of the present application also provide a radiopharmaceutical injection device comprising: a base; the injection needle is arranged on the base; the syringe assembly is arranged on the base and can move along a first direction relative to the base, the syringe assembly is provided with a first position and a second position, the syringe assembly comprises a first syringe and a second syringe, physiological saline is arranged in the first syringe, and a radioactive drug is arranged in the second syringe; the pushing component is arranged on the base and can move along a second direction relative to the base, and the first direction is perpendicular to the second direction; wherein, with the syringe assembly in the first position, the first syringe is in communication with the injection needle, and the pushing assembly moves in the second direction and pushes the first syringe; with the syringe assembly in the second position, the second syringe is in communication with the injection needle, and the pushing assembly moves in the second direction and pushes the second syringe.
In some alternative embodiments, the injection needle comprises: an injection part which can be connected into a vein of a patient; the movable part is arranged on the base and can move along a second direction relative to the base, the movable part and the pushing assembly are arranged at intervals, and the first injector or the second injector is arranged between the movable part and the pushing assembly, wherein the movable part can be communicated with the first injector or the second injector when the movable part moves along the second direction.
In some alternative embodiments, further comprising: the shielding component is arranged on the base and is provided with an accommodating space, the second syringe is arranged in the accommodating space, and the shielding component and the second syringe can move along the first direction relative to the base.
In some alternative embodiments, the shielding assembly includes: the shell is arranged on the base and is provided with a containing cavity; the first shielding body and the second shielding body are arranged in the accommodating cavity, one end of the second shielding body is sleeved on the first shielding body, the first shielding body can move relative to the second shielding body, the first shielding body and the second shielding body are of hollow structures, the first shielding body and the second shielding body form accommodating spaces, and when the movable portion moves along the second direction, the movable portion drives the first shielding body to move relative to the second shielding body, so that the second injector stretches out of the first shielding body and is communicated with the movable portion.
In some alternative embodiments, the shielding assembly further comprises: and the elastic piece is sleeved on the first shielding body, one end of the elastic piece is connected with the first shielding body, and the other end of the elastic piece is abutted against the second shielding body.
In some alternative embodiments, the shielding assembly further comprises: the third shielding body is connected to the second shielding body, and the third shielding body comprises a connecting part and an extending part, wherein the connecting part is connected with the second shielding body, the connecting part is provided with a through hole, the extending part is connected to the periphery of the through hole and extends along the direction deviating from the connecting part, the needle cylinder of the second injector is arranged in the accommodating space, and the push handle penetrates through the through hole and is arranged in the extending part.
In some alternative embodiments, the extension is provided with a through slot extending in the second direction through which the pushing position of the second syringe can be observed.
In some alternative embodiments, the circumferential side of the through slot is provided with a scale for indicating the push distance of the second syringe.
In some alternative embodiments, the housing is provided with a limit slot for connection with the protective assembly.
In some optional embodiments, the protection component comprises a limiting block, a first protection sleeve and a second protection sleeve, the first protection sleeve and the second protection sleeve are detachably connected, the first protection sleeve and the second protection sleeve are of hollow structures, the first protection sleeve and the second protection sleeve form a containing cavity, the shielding component is arranged in the containing cavity, the limiting block is arranged on one side, close to the limiting groove, of the first protection sleeve, and the limiting block is connected with the limiting groove in a matched mode.
In some alternative embodiments, the protection assembly further comprises: the blocking piece is arranged in the accommodating cavity, one end of the blocking piece is connected with the first protective sleeve, and the other end of the blocking piece is in butt joint with the first shielding body.
In some alternative embodiments, the moving assembly comprises: the sliding rail is arranged on the base and extends along the second direction; the pressure sensor is arranged on the base and is connected with the pushing piece; the pushing piece is arranged on the sliding rail in a sliding way; the first driving piece is connected with the pushing piece and can drive the pushing piece to slide along the second direction so as to push the first syringe or the second syringe.
In some alternative embodiments, the pushing assembly further comprises: the sliding block is arranged on the sliding rail in a sliding way, the sliding block and the pushing piece are arranged at intervals, and the movable part is connected with the sliding block; the second driving piece is connected with the sliding block and can drive the sliding block to slide along a second direction so that the movable part is communicated with the first syringe or the second syringe.
In some alternative embodiments, further comprising: the moving plate is arranged on the base, the moving plate can move along a first direction relative to the base, and the first injector and the second injector are respectively connected to the moving plate; the nut is arranged on the moving plate and connected with the moving plate, the moving plate is provided with the nut, and the nut is fixed on the moving plate; the screw rod is arranged on the base and connected with the screw nut, and the screw nut is driven to move along a first direction by the rotation of the screw rod; the third driving piece is connected to the screw rod and can drive the screw rod to rotate and drive the moving plate to move along the first direction through the screw nut.
In some alternative embodiments, the mobile plate is provided with a first clamping member which can clamp the first syringe; and/or the movable plate is provided with a second clamping piece, and the second clamping piece can clamp the second syringe.
In some alternative embodiments, further comprising: the hemostatic assembly is arranged on the base and comprises a tourniquet and an air pump, the air pump is arranged on the base, and the air pump is connected with the tourniquet.
In some alternative embodiments, the pushing assembly includes a direct injection mode and a bolus injection mode; the pushing component is configured to push the first injector and the second injector to complete injection work under the condition of a direct injection mode; the pushing assembly is configured to fill the tourniquet with blood in a bolus injection mode, the pushing assembly pushes the first syringe at a first frequency, and after the tourniquet is depressurized, the pushing assembly pushes the first syringe to complete the injection at a second frequency.
In some alternative embodiments, the first frequency is that the single pulse push volume is less than or equal to 0.1ml at the same peak injection speed and injection volume; the second frequency is that the single pulse push volume is greater than 1ml at the same peak injection speed and injection volume.
Embodiments of the second aspect of the present application also provide a method of operating an injection device, comprising the steps of: the first injector is communicated with the injection needle, and the pushing component pushes the first injector, so that the injection needle is filled with physiological saline in the first injector; after venipuncture, the second injector is communicated with an injection needle, and the second injector is pushed by a pushing component so that the radioactive drug in the second injector enters the injection needle tube; the first syringe is communicated with the injection needle, and the pushing component pushes the first syringe, so that the physiological saline in the first syringe is injected into the subject through the injection needle in a direct injection mode or a pulse injection mode.
In some alternative embodiments, the pulse injection mode specifically includes: the tourniquet is inflated through the air pump to stop bleeding, the pushing component pushes the first injector at a first frequency, after the predetermined volume of pushing injection is completed, the tourniquet is released, the pushing component pushes the first injector at a second frequency, wherein the first frequency is that the volume of single pulse pushing liquid is smaller than or equal to 0.1ml when the peak injection speed and the injection volume are the same; the second frequency is that the single pulse volume push volume is greater than 1ml at the same peak injection speed and injection volume.
According to the radiopharmaceutical injection device provided by the embodiment of the application, the injector assembly and the pushing assembly are arranged, the injector assembly can move along a first direction relative to the base, and the positions of the first injector and the second injector are alternately changed, so that the first injector is communicated with the injection needle or the second injector is communicated with the injection needle, the pushing assembly can move along a second direction to push the first injector and the second injector, and proper injection modes can be selected according to actual conditions, so that different injection modes are realized, the requirement of direct injection or bolus injection is met, and the injection effect of radiopharmaceuticals is ensured. In addition, the radiopharmaceutical injection device described above also reduces operator contact with a second syringe, needle, etc., thereby reducing the problem of prolonged exposure of the operator to radiation.
Drawings
In order to more clearly illustrate the technical solution of the embodiments of the present application, the drawings that are needed to be used in the embodiments of the present application will be briefly described, and it is possible for a person skilled in the art to obtain other drawings according to these drawings without inventive effort.
FIG. 1 is a schematic view of a radiopharmaceutical injection device in accordance with an embodiment of the application;
FIG. 2 is a schematic view of the syringe assembly of the radiopharmaceutical injection device of an embodiment of the present application in a first position;
FIG. 3 is a schematic view of the syringe assembly of the radiopharmaceutical injection device of an embodiment of the application in a second position;
FIG. 4 is an exploded view of the shielding assembly of the radiopharmaceutical injection device of an embodiment of the application;
FIG. 5 is a schematic view of the shielding assembly of a radiopharmaceutical injection device of an embodiment of the application;
FIG. 6 is a schematic view of a portion of a radiopharmaceutical injection device in accordance with an embodiment of the application;
FIG. 7 is a cross-sectional view of a radiopharmaceutical injection device in accordance with an embodiment of the application;
fig. 8 is a schematic view of a hemostatic assembly of a radiopharmaceutical injection device in accordance with an embodiment of the application.
Reference numerals illustrate:
100. a radiopharmaceutical injection device;
10. a base;
20. an injection needle; 21. an injection part; 22. a movable part;
30. a syringe assembly; 31. a first syringe; 32. a second syringe;
40. a pushing assembly; 41. a slide rail; 42. a pushing member; 43. a first driving member; 44. a pressure sensor; 45. a slide block; 46. a second driving member;
50. A shielding assembly; 51. a housing; 52. a first shield; 53. a second shield; 54. an elastic member; 55. a third shield;
60. a moving plate; 61. a first clamping member; 62. a second clamping member;
70. a screw rod;
80. a third driving member;
90. a hemostatic assembly; 91. a tourniquet; 911. a housing; 912. an air bag; 913. a flexible cloth.
Detailed Description
Features and exemplary embodiments of various aspects of the application are described in detail below. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the application. It will be apparent, however, to one skilled in the art that the present application may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the application by showing examples of the application. In the drawings and the following description, at least some well-known structures and techniques have not been shown in detail in order not to unnecessarily obscure the present application; also, the dimensions of some of the structures may be exaggerated for clarity. Furthermore, the described features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
In the description of the present application, it is to be noted that, unless otherwise indicated, the meaning of "plurality" is two or more; the terms "upper," "lower," "left," "right," "inner," "outer," and the like are merely used for convenience in describing the present application and to simplify the description, and do not denote or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus are not to be construed as limiting the present application. Furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
The directional terms appearing in the following description are all directions shown in the drawings and do not limit the specific structure of the embodiment of the present application. In the description of the present application, it should also be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be directly connected or indirectly connected. The specific meaning of the above terms in the present application can be understood as appropriate by those of ordinary skill in the art.
In order to solve the existing technical problems, the embodiment of the application provides a radiopharmaceutical injection device and a working method of the injection device. For a better understanding of the present application, a radiopharmaceutical injection device and method of operation of an injection device in accordance with embodiments of the present application are described in detail below with reference to fig. 1-8.
The radiopharmaceutical injection device provided by embodiments of the present application will be described first.
Referring to fig. 1 and 2, fig. 1 is a schematic view of a radiopharmaceutical injection device in accordance with an embodiment of the application; FIG. 2 is a schematic view of the syringe assembly of the radiopharmaceutical injection device of an embodiment of the present application in a first position; FIG. 3 is a schematic view of the syringe assembly of the radiopharmaceutical injection device of an embodiment of the application in a second position; fig. 4 is an exploded view of a shielding assembly of a radiopharmaceutical injection device in accordance with an embodiment of the application.
As shown in fig. 1, 2, 3 and 4, an embodiment of a first aspect of the present application provides a radiopharmaceutical injection device 100 comprising: a base 10; an injection needle 20 provided on the base 10; the syringe assembly 30 is disposed on the base 10, and the syringe assembly 30 can move along a first direction relative to the base 10, the syringe assembly 30 has a first position and a second position, the syringe assembly 30 includes a first syringe 31 and a second syringe 32, the first syringe 31 is provided with physiological saline, and the second syringe 32 is provided with a radiopharmaceutical; the pushing component 40 is arranged on the base, the pushing component 40 can move along a second direction relative to the base 10, the first direction is perpendicular to the second direction, wherein the first syringe 31 is communicated with the injection needle 20 when the syringe component 30 is positioned at the first position, and the pushing component 40 moves along the second direction and pushes the first syringe 31; with the syringe assembly 30 in the second position, the second syringe 32 is in communication with the needle 20, and the push assembly 40 moves in the second direction and pushes the second syringe 32.
The base 10 serves as a mounting base for the needle 20, syringe assembly 30, push assembly 40, etc., and provides support for the needle 20, syringe assembly 30, and push assembly 40, as well as at least provides clearance for the syringe assembly 30 and push assembly 40 such that the syringe assembly 30 moves in a first direction relative to the base 10 and the push assembly 40 moves in a second direction relative to the base 10. The shape, size, etc. of the base 10 may be set according to practical requirements, and for example, the shape of the base 10 may be selected from a rectangular structure, a trapezoidal structure, a cylindrical structure, etc.
The syringe assembly 30 is disposed on the base 10, and the syringe assembly 30 is movable along a first direction relative to the base 10, wherein the syringe assembly 30 includes a first syringe 31 and a second syringe 32, the first syringe 31 is provided with physiological saline, and the second syringe 32 is provided with a radiopharmaceutical. When the syringe assembly 30 is moved to the first position, the first syringe 31 is communicated with the injection needle 20, and the physiological saline in the first syringe 31 can be pushed into the injection needle 20 by pushing the first syringe 31 to discharge the air bubbles in the injection needle 20. When the syringe assembly 30 is moved to the second position, the second syringe 32 is in communication with the needle 20, and the radiopharmaceutical in the second syringe 32 may be pushed into the needle 20 by pushing the second syringe 32 to inject the radiopharmaceutical through the needle 20 into the subject. The syringe assembly 30 is reciprocally movable in a first direction such that the first syringe 31 and the second syringe 32 alternately communicate with the needle 20.
The pushing assembly 40 is movable in a second direction relative to the base 10, and the pushing assembly 40 is used to push the first syringe 31 and the second syringe 32 so as to push the physiological saline in the first syringe 31 or the radiopharmaceutical in the second syringe 32 into the injection needle 20.
In the embodiment of the present application, as shown in fig. 2 and 3, when the syringe assembly 30 moves in the first direction and the first syringe 31 approaches the injection needle 20, the first syringe 31 is driven by the syringe assembly 30 to move toward the injection needle 20, so that the first syringe 31 is communicated with the injection needle 20, and the syringe assembly 30 is at the first position; alternatively, when the syringe assembly 30 is moved in the first direction and the first syringe 31 is adjacent to the needle 20, the needle 20 may be moved in the direction of the first syringe 31 such that the first syringe 31 is in communication with the needle 20, with the syringe assembly 30 in the first position. Similarly, when the syringe assembly 30 moves in the first direction and the second syringe 32 approaches the needle 20, the syringe assembly 30 drives the second syringe 32 to move toward the needle 20, so that the second syringe 32 is communicated with the needle 20, and the syringe assembly 30 is at the second position; alternatively, when the syringe assembly 30 is moved in the first direction and the second syringe 32 is adjacent to the needle 20, the needle 20 may be moved in the direction of the second syringe 32 such that the second syringe 32 is in communication with the needle 20, with the syringe assembly 30 in the second position.
Optionally, the pushing assembly 40 is collinear with the needle 20 in the second direction.
Alternatively, when the base 10 is in a rectangular structure, the first direction is the X direction, i.e. the width direction of the base 10, and the second direction is the Y direction, i.e. the length direction of the base 10, and the first direction is perpendicular to the second direction.
According to the radiopharmaceutical injection device 100 provided by the embodiment of the application, the injector assembly 30 and the pushing assembly 40 are arranged, the injector assembly 30 can move along the first direction relative to the base 10, and the positions of the first injector 31 and the second injector 32 are alternately changed, so that the first injector 31 is communicated with the injection needle 20 or the second injector 32 is communicated with the injection needle 20, the pushing assembly 40 can move along the second direction to push the first injector 31 and the second injector 32, and the proper injection mode of the pushing assembly 40 can be selected according to actual conditions, so that different injection modes are realized, the requirements of direct injection or bolus injection are met, and the injection effect of the radiopharmaceutical is ensured. In addition, the radiopharmaceutical injection device 100 described above may also reduce operator contact with the second syringe 32, the needle 20, etc., thereby reducing operator exposure to radiation for extended periods of time.
In some alternative embodiments, as shown in fig. 1 and 4, the injection needle 20 comprises: the injection unit 21 can access the vein of the subject; the movable portion 22 is disposed on the base 10, and the movable portion 22 is movable along a second direction relative to the base 10, the movable portion 22 is spaced from the pushing assembly 40, and the first syringe 31 or the second syringe 32 is disposed between the movable portion 22 and the pushing assembly 40, wherein the movable portion 22 is capable of communicating with the first syringe 31 or the second syringe 32 when the movable portion 22 moves along the second direction.
In the embodiment of the present application, the injection needle 20 includes the injection part 21 and the movable part 22, the injection part 21 can be connected to the vein of the subject, the movable part 22 can be communicated with the first syringe 31 or the second syringe 32, and the movable part 22 can move in the second direction relative to the base 10, so that the movable part 22 can be connected or disconnected with the first syringe 31 or the second syringe 32.
Illustratively, when the first syringe 31 and the second syringe 32 move synchronously in the first direction and the first syringe 31 moves to align with the movable portion 22, the movable portion 22 moves in the second direction toward the first syringe 31 to communicate the first syringe 31 with the movable portion 22, and the pushing assembly 40 moves in the second direction and pushes the first syringe 31 to inject the saline in the first syringe 31 into the needle 20.
Illustratively, when the first syringe 31 and the second syringe 32 are moved in synchrony in a first direction and the second syringe 32 is moved into alignment with the movable portion 22, the movable portion 22 is moved in a second direction toward the second syringe 32 to place the second syringe 32 in communication with the movable portion 22, the pushing assembly 40 is moved in the second direction and pushes the second syringe 32 to cause the radiopharmaceutical in the second syringe 32 to be injected into the needle 20.
In these alternative embodiments, the arrangement is such that the first syringe 31 and the second syringe 32 are movable in a first direction, the push assembly 40 and the movable portion 22 are movable in a second direction, and each member is movable in only one direction, simplifying the overall operation of the device described above, and ensuring the stability of movement of each member to achieve accurate operation and thus ensure the effectiveness of the injection of the radiopharmaceutical.
In some alternative embodiments, as shown in fig. 1 and 4, the device further comprises a shielding assembly 50 disposed on the base 10, the shielding assembly 50 having a receiving space in which the second syringe 32 is disposed, and the shielding assembly 50 being movable with the second syringe 32 in the first direction relative to the base 10.
In the embodiment of the present application, the shielding assembly 50 has a receiving space, at least a portion of the second syringe 32 is disposed in the receiving space, it can be understood that the second syringe 32 is completely embedded in the receiving space of the shielding assembly 50, the receiving space is a non-closed space, at this time, the movable portion 22 can extend into the receiving space to communicate with the second syringe 32, and the pushing assembly 40 can extend into the receiving space and push the pushing handle of the second syringe 32.
In the embodiment of the present application, the shielding assembly 50 may be an integral structure or a split structure.
In these alternative embodiments, the shielding assembly 50 is configured to provide a radiation shielding effect, and the shielding assembly 50 is configured to provide a shielding effect during movement of the pushing assembly 40 in the second direction and pushing of the second syringe 32 to inject the radiopharmaceutical in the second syringe 32 into the needle 20, thereby further reducing radiation exposure to the operator.
Referring to fig. 5 in combination, fig. 5 is a schematic view of the shielding assembly of a radiopharmaceutical injection device in accordance with an embodiment of the application.
In some alternative embodiments, as shown in fig. 4 and 5, the shielding assembly 50 includes: a housing 51 provided on the base 10, the housing 51 having a housing chamber; the first shielding body 52 and the second shielding body 53, the first shielding body 52 and the second shielding body 53 are arranged in the accommodating cavity, one end of the second shielding body 53 is sleeved on the first shielding body 52, the first shielding body 52 can move relative to the second shielding body 53, the first shielding body 52 and the second shielding body 53 are of hollow structures, the first shielding body 52 and the second shielding body 53 form an accommodating space, and when the movable portion 22 moves along the second direction, the movable portion 22 drives the first shielding body 52 to move relative to the second shielding body 53, so that the second syringe 32 extends out of the first shielding body 52 and is communicated with the movable portion 22.
In an embodiment of the present application, the shielding assembly 50 includes a housing 51, a first shielding body 52, and a second shielding body 53. The casing 51 is sleeved outside the first shielding body 52 and the second shielding body 53, one end of the casing 51 can be connected with the movable part 22, the first shielding body 52 and the second shielding body 53 are of hollow structures, the first shielding body 52 and the second shielding body 53 form an accommodating space, the second injector 32 is embedded in the accommodating space, one end of the second shielding body 53 is sleeved on the first shielding body 52, the first shielding body 52 can move relative to the second shielding body 53, and it can be understood that the first shielding body 52 stretches and contracts relative to the second shielding body 53, the second injector 32 is arranged in the first shielding body 52 when the first shielding body 52 stretches, and the second injector 32 is not communicated with the movable part 22; the second syringe 32 extends out of the first shield 52 and communicates with the movable portion 22 when the first shield 52 is in the retracted state, which is based on the movable portion 22 pressing the first shield 52 against the second shield 53 so that the first shield 52 assumes the retracted state.
In these alternative embodiments, the housing 51 is sleeved over the first shield 52 and the second shield 53, and the second syringe 32 is disposed within the housing space defined by the first shield 52 and the second shield 53, with the syringe assembly 30 in the first position, the first shield 52 is sleeved over the radiopharmaceutical syringe of the second syringe 32, effectively reducing radiation from the radiopharmaceutical. With the syringe assembly 30 in the second position, the first shield 52 is in contact with the movable portion 22 and the first shield 52 is retracted, the second syringe 32 extends beyond the first shield 52 into communication with the movable portion 22, and the push assembly 40 pushes the second syringe 32 such that the first shield 52 is in contact with the movable portion 22 during injection of the radiopharmaceutical in the second syringe 32 into the needle 20 to form a relatively communicating space between the second syringe 32 and the needle 20 through the movable portion 22, thereby injecting the radiopharmaceutical into the needle 20.
In some alternative embodiments, the shielding assembly 50 further includes an elastic member 54 sleeved on the first shielding body 52, where one end of the elastic member 54 is connected to the first shielding body 52, and the other end abuts against the second shielding body 53.
Alternatively, the elastic member 54 is selected from at least one of a linear spring, a torsion spring, a spring piece, a solid elastic rubber, a porous elastic rubber, a solid elastic plastic, a porous elastic plastic, a memory metal, and a magnetic member.
In these alternative embodiments, the elastic member 54 provides a pushing force to the first shielding body 52, when the first shielding body 52 is pressed by the movable portion 22 to the retracted state, the elastic member 54 is in shrinkage deformation under an external load, and when the movable portion 22 releases the pressure on the first shielding body 52, the first shielding body 52 is moved in a direction away from the second shielding body 53 based on the resilience force (pushing force) after the shrinkage of the elastic member 54, so that the first shielding body 52 is automatically restored to the uncompressed state, and the second syringe 32 is housed in the first shielding body 52.
In some alternative embodiments, the shielding assembly 50 further includes a third shielding body 55 connected to the second shielding body 53, the third shielding body 55 includes a connection portion connected to the second shielding body 53, the connection portion is provided with a through hole, and an extension portion connected to a peripheral side of the through hole and extending in a direction away from the connection portion, the syringe of the second syringe 32 is disposed in the receiving space, and the push handle penetrates through the through hole and is disposed in the extension portion.
Optionally, the third shield 55 is threadedly coupled to the second shield 53. In this way, the third shield 55 is made detachable from the second shield 53, and the second syringe 32 is put into the third shield 55 and the second shield 53 and extends to the first shield 52.
Optionally, the end of the push handle of the second syringe 32 is located on the third shield 55.
In these alternative embodiments, this arrangement facilitates the installation and removal of the second syringe 32.
In some alternative embodiments, the extension is provided with a through slot that extends in the second direction, through which the pushing position of the second syringe 32 can be observed.
In these alternative embodiments, the push position of the second syringe 32 may be observed through the through slot to determine the push condition of the second syringe 32, as well as the remaining condition of the radiopharmaceutical in the second syringe 32.
In some alternative embodiments, the circumferential side of the through slot is provided with graduations for indicating the push distance of the second syringe 32.
In these alternative embodiments, reading the volume of the radiopharmaceutical in the second syringe 32 within the shielding assembly 50 without contacting the second syringe 32 may be accomplished by reading the corresponding scale location on the end of the second syringe 32.
In some alternative embodiments, the housing 51 is provided with a limit slot for connection with the protective assembly.
In the embodiment of the application, the protection component is connected with the shell 51 through the limiting groove, the protection component comprises a sliding block 45 and is slidably connected with the limiting groove, and the protection component can also comprise a protruding block and is clamped with the limiting groove.
In these alternative embodiments, the protective assembly may be placed over the housing 51, which may be required during shipping because the housing 51 is not completely enclosed. The protective assembly is opened prior to injection and the shielding assembly 50 containing the second syringe 32 is placed into the radiopharmaceutical injection apparatus 100 to complete the injection and removed from the radiopharmaceutical injection apparatus 100 and replaced into the protective assembly after the injection is completed to avoid radiation leakage.
In some alternative embodiments, the protection component includes a stopper, a first protection sleeve and a second protection sleeve, the first protection sleeve is detachably connected with the second protection sleeve, the first protection sleeve and the second protection sleeve are hollow structures, the first protection sleeve and the second protection sleeve form a containing cavity, the shielding component 50 is arranged in the containing cavity, the stopper is arranged on one side of the first protection sleeve close to the limit groove, and the stopper is connected with the limit groove in a matching manner.
In these alternative embodiments, the stopper is disposed on a side of the first protective sleeve near the limit slot, and is configured to slidingly engage with the limit slot, so as to guide the shielding assembly 50 to be inserted into the first protective sleeve, and define the movement of the shielding assembly 50 in the accommodating cavity formed by the first protective sleeve and the second protective sleeve, so as to reduce the leakage of the internal radiopharmaceutical caused by frequent collision between the shielding assembly 50 and the protective assembly. In addition, when the shielding assembly 50 is disposed within the protective assembly, the first protective sheath may be separated from the second protective sheath, and the shielding assembly 50 may be removed by holding the third shield 55.
In some alternative embodiments, the protection assembly further includes a blocking member disposed in the receiving cavity, one end of the blocking member is connected to the first protection sleeve, and the other end abuts the first shielding body 52.
In these alternative embodiments, a blocking member cooperates with the first shield 52 to block the open end of the first shield 52 from radiation leakage, i.e., the junction of the first shield 52 and the movable portion 22. In addition, the blocking assembly has one end connected to the first protective sheath and the other end abutting the first shield 52, and further defines movement of the shield assembly 50 within the protective assembly.
Referring to fig. 6-7 in combination, fig. 6 is a schematic view of a portion of a radiopharmaceutical injection device in accordance with an embodiment of the application; fig. 7 is a cross-sectional view of a radiopharmaceutical injection device in accordance with an embodiment of the application.
In some alternative embodiments, as shown in fig. 6 and 7, the pushing assembly 40 includes: a sliding rail 41 disposed on the base 10, the sliding rail 41 extending along the second direction; a pushing member 42 slidably disposed on the sliding rail 41; a pressure sensor 44 provided on the base 10 and connected to the pusher 42; the first driving member 43 is connected to the pushing member 42, and the first driving member 43 can drive the pushing member 42 to slide along the second direction so as to push the first syringe 31 or the second syringe 32.
In the embodiment of the present application, the pushing assembly 40 includes a sliding rail 41, a pushing member 42, a first driving member 43 and a pressure sensor 44, wherein the pushing member 42 is driven by the first driving member 43 to move on the sliding rail 41 along a second direction, the pushing member 42 can be close to or far from the first syringe 31 or the second syringe 32 along the second direction, and the pressure sensor 44 can be contacted with a pushing handle of the first syringe 31 or the second syringe 32 for detecting injection force during injection to identify whether a blocking condition occurs.
Illustratively, when the first syringe 31 and the second syringe 32 move synchronously in the first direction and the first syringe 31 moves to align with the movable portion 22, the movable portion 22 moves in the second direction toward the first syringe 31 to communicate the first syringe 31 with the movable portion 22, the first driving member 43 drives the pushing member 42 to move in the second direction toward the first syringe 31, the pushing member 42 abuts against the first syringe 31, and the first driving member 43 continuously applies work to push the first syringe 31 so that the saline in the first syringe 31 is injected into the injection needle 20. After the normal saline injection is completed, the movable part 22 moves in the direction away from the first syringe 31 in the second direction, the first syringe 31 is disconnected from the movable part 22, and the first driving member 43 drives the pushing member 42 to move in the direction away from the first syringe 31 in the second direction.
Illustratively, when the second syringe 32 is moved in synchronization with the second syringe 32 in the first direction and the second syringe 32 is moved to align with the movable portion 22, the movable portion 22 is moved in a second direction toward the second syringe 32 to communicate the second syringe 32 with the movable portion 22, the first driver 43 drives the pusher 42 to move in the second direction toward the second syringe 32, the pusher 42 abuts the second syringe 32, and the first driver 43 continues to apply work such that the pusher 42 pushes the second syringe 32 to inject the radiopharmaceutical into the needle 20 in the second syringe 32. After the radiopharmaceutical injection is completed, the movable portion 22 is moved in a second direction away from the second syringe 32, the second syringe 32 is disconnected from the movable portion 22, and the first driver 43 drives the pusher 42 in the second direction away from the second syringe 32.
In some alternative embodiments, the pushing assembly 40 further comprises: the sliding block 45, the sliding block 45 is slidably arranged on the sliding rail 41, the sliding block 45 is arranged at intervals with the pushing piece 42, and the movable part 22 is connected with the sliding block 45; the second driving member 46 is connected to the slider 45, and the second driving member 46 can drive the slider 45 to slide along the second direction, so that the movable portion 22 communicates with the first syringe 31 or the second syringe 32.
In these alternative embodiments, the movable portion 22 and the sliding block 45 share a sliding rail 41, which can move along the second direction, so as to simplify the overall structure of the device.
In other alternative embodiments, as shown in fig. 6, the injector further includes a sliding slot, a sliding block 45, and a second driving member 46, where the sliding block 45 is slidably disposed in the sliding slot, and the sliding slot and the sliding rail 41 extend along the second direction and are spaced apart from each other, so that the sliding block 45 and the pushing member 42 are spaced apart from each other and are on the same line, and the second driving member 46 is connected to the sliding block 45, and the second driving member 46 can drive the sliding block 45 to slide along the second direction, so that the movable portion 22 communicates with the first injector 31 or the second injector 32.
In some alternative embodiments, as shown in fig. 6, further comprising: the moving plate 60 is arranged on the base 10, the moving plate 60 can move along a first direction relative to the base 10, the first injector 31 and the second injector 32 are respectively connected to the moving plate 60, the moving plate 60 is provided with a nut, and the nut is fixed on the moving plate 60; the screw 70, the screw 70 is set up in the base 10 and connected to nut, the screw 70 rotates and makes the nut move along the first direction; the third driving member 80 is connected to the screw rod 70, and the third driving member 80 can drive the screw rod 70 to rotate through the nut to drive the moving plate 60 to move along the first direction.
In these alternative embodiments, the radiopharmaceutical injection device 100 further includes a movable plate 60, a nut, a lead screw 70, and a third driver 80, the lead screw 70 being driven by the third driver 80 to rotate through the nut to reciprocate the movable plate 60 in the first direction.
In some alternative embodiments, the moving plate 60 is provided with a first clamping member 61, the first clamping member 61 being adapted to clamp the first syringe 31.
In some alternative embodiments, the mobile plate 60 is provided with a second clamping member 62, the second clamping member 62 being adapted to clamp the second syringe 32.
Referring to fig. 8 in combination, fig. 8 is a schematic view of a hemostatic assembly of a radiopharmaceutical injection device in accordance with an embodiment of the application.
In some alternative embodiments, as shown in fig. 1 and 8, a hemostatic assembly 90 is further included and disposed on the base 10, the hemostatic assembly 90 includes a tourniquet 91 and an air pump disposed on the base 10 and connected to the tourniquet 91.
Optionally, the tourniquet 91 comprises a housing 911, an air bladder 912, and a flexible cloth 913, with the air pump in communication with the air bladder 912.
In embodiments of the present application, the tourniquet 91 is designed in a manner that includes, but is not limited to, a ring tourniquet, a tie tourniquet, a solid extruded tourniquet, etc.
In these alternative embodiments, the bolus injection is enhanced by providing a hemostatic assembly 90 that cooperates with the needle 20, syringe assembly 30, and push assembly 40. The pressure of the tourniquet 91 to the squeezing position can be adjusted by the air pump in combination with the air pressure sensor, so that the hemostatic pressure can be accurately controlled. In addition, the setting of the hemostatic assembly 90 allows the radiopharmaceutical injection apparatus 100 to have an automatic hemostatic function, and due to the application of the automatic hemostatic assembly 90, the radiopharmaceutical will stay near the tourniquet 91 after the injection is completed, and along with the release of the tourniquet 91, the radiopharmaceutical will rapidly enter the body along with the blood flow and the physiological saline assisting the injection due to the action of the intravenous pressure, and under the automatic cooperation of this mode, the bolus injection effect can be further improved while avoiding the failure risk.
In some alternative embodiments, the push assembly 40 includes a direct injection mode and a bolus injection mode. The pushing assembly 40 is configured to push the first syringe 31 and the second syringe 32 to complete the injection work in the case of the direct injection mode. In the case where the pushing assembly 40 is configured to operate in the bolus injection mode, the tourniquet 91 fills with blood, the pushing assembly 40 pushes the first syringe 31 at the first frequency, and after the tourniquet 91 is depressurized, the pushing assembly 40 pushes the first syringe 31 to complete the injection operation at the second frequency 32.
Illustratively, in the direct bolus mode, the first syringe 31 is in communication with the needle 20, and the pushing assembly 40 is configured to push the first syringe 31 at a constant and relatively low pushing rate so that the saline in the first syringe 31 fills the needle 20; the second syringe 32 is then in communication with the needle 20, and the pushing assembly 40 is configured to push the second syringe 32 at a constant and relatively low push rate so that the radiopharmaceutical in the second syringe 32 enters the needle 20; the first syringe 31 is then placed in communication with the needle 20, and the pushing assembly 40 is configured to push the first syringe 31 at a constant and relatively low pushing rate so that the saline in the first syringe 31 is injected into the subject by pushing the radiopharmaceutical into the needle 20.
Illustratively, in the pulse injection mode, the first syringe 31 is in communication with the needle 20, and the pushing assembly 40 is configured to push the first syringe 31 at a constant and relatively low pushing speed so that the saline in the first syringe 31 fills the needle 20; the second syringe 32 is then in communication with the needle 20, and the pushing assembly 40 is configured to push the second syringe 32 at a constant and relatively low push rate so that the radiopharmaceutical in the second syringe 32 enters the needle 20; then, the first injector 31 is communicated with the injection needle 20, at this time, the air pump pressurizes the tourniquet 91 to reach the hemostatic pressure, and the pushing component 40 is configured to push the first injector 31 at the first frequency, i.e. the single pulse pushes the pulse volume with the volume of less than 0.1ml to inject; when the flush volume is reached (typically the first frequency maintains a total volume of no more than 1.5 ml), the tourniquet 91 automatically releases pressure and the push assembly 40 is configured to push the first syringe 31 at the second frequency, i.e., a single pulse push with a pulse volume of 1ml or more, to inject until the bolus is complete.
In some alternative embodiments, the first frequency is that the single pulse push volume is less than or equal to 0.1ml at the same peak injection speed and injection volume. The second frequency is that the single pulse push volume is greater than 1ml at the same peak injection speed and injection volume.
In the embodiment of the application, the inventor finds that by adopting a peristaltic pump to provide blood flow power and adopting a simulated bionic arm to perform an in-vitro bolus injection simulation experiment through researching a first frequency and a second frequency in a pulse injection mode, when the same total amount of physiological saline is injected, a larger volume of physiological saline bolus is beneficial to improving injection efficiency, a smaller volume of physiological saline bolus is beneficial to reducing effective flushing liquid amount, for example, a pulse liquid bolus with a single pulse pushing liquid volume of 80 microliters only needs 1.46ml of physiological saline to completely clean nuclides in a pipeline, the consumption liquid amount is 49% less than that of a non-pulse injection, and the damage risk to veins can be reduced by using small liquid bolus flushing in a hemostatic state. Therefore, pushing the first syringe 31 with the first frequency can be understood as high-frequency small-volume pulse injection, which can reduce the amount of the physiological saline solution flushed by the pipeline; the second frequency is adopted to push the first injector 31, so that the injection efficiency can be improved by low-frequency large-volume pulse injection, and the pellet aggregation of the injection of the radiopharmaceuticals can be improved by matching the tourniquet, so that the pellet injection effect is improved.
Optionally, in the pulse injection mode, the controller controls the hemostatic assembly 90 to be in a precise fit with the pusher assembly 40. By the arrangement, the consistency of injection can be ensured, and the pellet injection effect is further improved.
Embodiments of the second aspect of the present application also provide a method of operating an injection device, comprising the steps of:
communicating the first syringe 31 with the injection needle 20, pushing the first syringe 31 by the pushing assembly 40 so that the physiological saline in the first syringe 31 fills the injection needle 20;
after venipuncture, second syringe 32 is placed in communication with needle 20 and second syringe 32 is pushed by push assembly 40 to cause the radiopharmaceutical in second syringe 32 to enter needle 20;
the first syringe 31 is communicated with the injection needle 20, and the first syringe 31 is pushed by the pushing assembly 40 so that the physiological saline in the first syringe 31 is injected into the subject through the injection needle 20 in the direct injection mode or the pulse injection mode.
According to the working method of the injection device, physiological saline is filled in the injection needle 20 to remove gas in the injection needle 20, after venipuncture is completed, the radioactive drug is injected into the injection needle 20 in a pushing mode, and then a direct injection mode or a pulse injection mode is selected to be injected into a subject through the injection needle 20. The working method of the injection device can provide doctors with proper injection modes according to actual conditions so as to meet the requirements of direct injection or bolus injection and ensure the injection effect of the radiopharmaceuticals. In addition, the operator's contact with the radiopharmaceutical can be reduced, thereby reducing the operator's exposure to radiation for extended periods of time.
In an embodiment of the present application, in the direct injection mode, the saline in the first syringe 31 and the radionuclide in the second syringe 32 will be injected into the subject at a constant and slower rate.
In an embodiment of the present application, the pulse injection mode specifically includes: the tourniquet 91 is inflated by the air pump to stop bleeding, the pushing component 40 pushes the first injector 31 at a first frequency, after the predetermined volume of pushing is completed, the tourniquet 91 is released, the pushing component 40 pushes the first injector 31 at a second frequency, wherein the first frequency is that the volume of pushing liquid of a single pulse is less than or equal to 0.1ml when the peak injection speed and the injection volume are the same; the second frequency is that the single pulse push volume is greater than 1ml at the same peak injection speed and injection volume.
In the embodiment of the application, the radioactive drug is injected into the injection needle tube firstly, the low-liquid-amount injection needle tube is flushed by adopting the first frequency injection physiological saline under the hemostatic state, and the radioactive drug is efficiently introduced into the human body by adopting the second frequency injection physiological saline after the tourniquet is released.
Other constructions and operations of radiopharmaceutical injection devices according to embodiments of the application are known to those of ordinary skill in the art and will not be described in detail herein in the description of the present application, the description of the terms "one embodiment," "some embodiments," "exemplary," "embodiments of the application," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While the application has been described with reference to a preferred embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the application. In particular, the technical features mentioned in the respective embodiments may be combined in any manner as long as there is no structural conflict. The present application is not limited to the specific embodiments disclosed herein, but encompasses all technical solutions falling within the scope of the claims.
Claims (12)
1. A radiopharmaceutical injection device, comprising:
a base;
the injection needle is arranged on the base and comprises an injection part and a movable part, the injection part can be connected with a vein of a subject, and the movable part is arranged on the base;
the syringe assembly is arranged on the base and can move along a first direction relative to the base, the syringe assembly is provided with a first position and a second position, the syringe assembly comprises a first syringe and a second syringe, physiological saline is arranged in the first syringe, and radiopharmaceuticals are arranged in the second syringe;
the pushing component is arranged on the base, the pushing component can move along a second direction relative to the base, the first direction is perpendicular to the second direction, the movable part can move along the second direction relative to the base, the movable part and the pushing component are arranged at intervals, the first injector or the second injector is arranged between the movable part and the pushing component, when the movable part moves along the second direction, the movable part can be communicated with the first injector or the second injector, the pushing component comprises a sliding rail, a pushing piece, a pressure sensor, a first driving piece, a sliding block and a second driving piece, the sliding rail is arranged on the base, the sliding rail extends along the second direction, the pressure sensor is arranged on the sliding rail, and is connected with the pushing piece, the first driving piece can drive the pushing piece to slide along the second direction, when the movable part moves along the second direction, the second injector or the second injector is arranged on the second injector, the sliding piece is connected with the sliding block, the second driving piece is arranged on the sliding block, the second injector is communicated with the sliding block or the second injector, the second driving piece is connected with the sliding block, the second injector is arranged on the sliding block, the sliding block is connected with the sliding piece, the sliding block is arranged on the sliding block, the sliding block or the sliding block is arranged on the sliding block, and the sliding block or the sliding block, the pushing component moves along a second direction and pushes the second syringe;
The hemostatic assembly is arranged on the base and comprises a tourniquet and an air pump, the air pump is arranged on the base and is connected with the tourniquet;
wherein the pushing assembly comprises a direct injection mode and a bolus injection mode, and is configured to push the first injector and the second injector to complete injection work under the condition of the direct injection mode;
the pushing component is configured to fill the tourniquet with blood under the condition of the bolus injection mode, the pushing component pushes the first injector at a first frequency, after the tourniquet is depressurized, the pushing component pushes the first injector to complete injection work at a second frequency, the first frequency is that the single pulse pushing liquid volume is smaller than or equal to 0.1ml under the same peak injection speed and injection volume, and the second frequency is that the single pulse pushing liquid volume is larger than 1ml under the same peak injection speed and injection volume.
2. The radiopharmaceutical injection device of claim 1, further comprising:
the shielding component is arranged on the base and is provided with an accommodating space, the second injector is arranged in the accommodating space, and the shielding component and the second injector can move along a first direction relative to the base.
3. The radiopharmaceutical injection device of claim 2 wherein the shielding assembly comprises:
the shell is arranged on the base and is provided with a containing cavity;
the first shielding body and the second shielding body are arranged in the accommodating cavity, one end of the second shielding body is sleeved on the first shielding body, the first shielding body can move relative to the second shielding body, the first shielding body and the second shielding body are hollow structures, the first shielding body and the second shielding body form the accommodating space,
when the movable part moves along the second direction, the movable part drives the first shielding body to move relative to the second shielding body, so that the second injector extends out of the first shielding body and is communicated with the movable part.
4. The radiopharmaceutical injection device of claim 3 wherein the shielding assembly further comprises:
the elastic piece is sleeved on the first shielding body, one end of the elastic piece is connected with the first shielding body, and the other end of the elastic piece is abutted to the second shielding body.
5. The radiopharmaceutical injection device of claim 3 wherein the shielding assembly further comprises:
The third shielding body is connected to the second shielding body, the third shielding body comprises a connecting portion and an extending portion, the connecting portion is connected with the second shielding body, the connecting portion is provided with a through hole, the extending portion is connected to the periphery side of the through hole and extends along the direction deviating from the connecting portion, a needle cylinder of the second injector is arranged in the accommodating space, and the pushing handle penetrates through the through hole and is arranged in the extending portion.
6. The radiopharmaceutical injection device of claim 5 wherein,
the extending part is provided with a through groove, the through groove extends along a second direction, and the pushing position of the second injector can be observed through the through groove.
7. The radiopharmaceutical injection device of claim 6 wherein,
the circumference side of the through groove is provided with scales, and the scales are used for indicating the pushing distance of the second injector.
8. The radiopharmaceutical injection device of claim 3 wherein,
the shell is provided with a limit groove which is used for being connected with the protection component.
9. The radiopharmaceutical injection device of claim 8 wherein,
The protection component comprises a limiting block, a first protection sleeve and a second protection sleeve, wherein the first protection sleeve is detachably connected with the second protection sleeve, the first protection sleeve and the second protection sleeve are of hollow structures, the first protection sleeve and the second protection sleeve form a containing cavity, the shielding component is arranged in the containing cavity, the limiting block is arranged on one side, close to the limiting groove, of the first protection sleeve, and the limiting block is connected with the limiting groove in a matched mode.
10. The radiopharmaceutical injection device of claim 9 wherein the protective component further comprises:
the blocking piece is arranged in the accommodating cavity, one end of the blocking piece is connected with the first protective sleeve, and the other end of the blocking piece is in butt joint with the first shielding body.
11. The radiopharmaceutical injection device of claim 1, further comprising:
the moving plate is arranged on the base, the moving plate can move along a first direction relative to the base, the first injector and the second injector are respectively connected with the moving plate, the moving plate is provided with a screw nut, and the screw nut is fixed on the moving plate;
The screw rod is arranged on the base and connected with the screw nut, and the screw nut moves along a first direction by rotating the screw rod;
the third driving piece is connected with the screw rod and can drive the screw rod to rotate and drive the moving plate to move along the first direction through the screw nut.
12. The radiopharmaceutical injection device of claim 11 wherein,
the moving plate is provided with a first clamping piece, and the first clamping piece can clamp the first syringe; and/or the number of the groups of groups,
the movable plate is provided with a second clamping piece, and the second clamping piece can clamp the second syringe.
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| CN202211510304.3A CN116077759B (en) | 2022-11-29 | 2022-11-29 | Radiopharmaceutical injection device and method of operation thereof |
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| CN104107501A (en) * | 2014-06-30 | 2014-10-22 | 张式琦 | Full-protection multifunctional full-automatic injection trolley and using method thereof |
| CN108339188A (en) * | 2017-01-23 | 2018-07-31 | 上海长海医院 | Contrast apparatus |
| WO2021093325A1 (en) * | 2019-11-15 | 2021-05-20 | 深圳迈瑞科技有限公司 | Injection pump |
| CN215129521U (en) * | 2021-05-18 | 2021-12-14 | 中南大学湘雅三医院 | Automatic elastic device of pulse-restraining belt for shot injection |
| CN216877582U (en) * | 2021-11-17 | 2022-07-05 | 诚进株式会社 | Automatic injection device for radioactive liquid medicine |
| CN217886682U (en) * | 2022-02-07 | 2022-11-25 | 苏州泽德医疗器械有限公司 | Medicine injection execution system |
| CN115040770A (en) * | 2022-06-14 | 2022-09-13 | 山东大学齐鲁医院 | Radiopharmaceutical injection device, full-automatic injection vehicle and injection method |
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