CN116077112A - Vascular closure, vascular closure system and method for operating vascular closure system - Google Patents

Abstract

The invention provides a vascular closure, a vascular closure system and an operation method of the vascular closure system, wherein the vascular closure comprises a grabber and a lead needle; one end of the gripper is provided with a coil; the lead wire needle is used for being detachably connected with the closed wire assembly and used for driving a part of the closed wire assembly to penetrate into the coil and then be separated from the closed wire assembly; the gripper is configured to move axially along itself to pull the closure wire assembly through the coil, causing the closure wire assembly to retract a target object to be closed. So configured, by driving the lead wire needle, a portion of the closed wire assembly can be threaded into the coil; and then drive the grabber, utilize the coil on it to pull the closed line subassembly, and then make the closed line subassembly receive and draw the target object that waits to seal, be applicable to the puncture of various apertures on the one hand, on the other hand does not have the residue or the degradable thing remains, fully guarantees security and reliability.

Description

Vascular closure, vascular closure system and method for operating vascular closure system

Technical Field

The invention relates to the technical field of medical instruments, in particular to a vascular closure device, a vascular closure system and an operation method of the vascular closure system.

Background

Since the advent of minimally invasive surgery, percutaneous vascular puncture techniques have been applied for nearly half a century, and how to quickly and safely stop bleeding from a puncture remains a clinical challenge. For a long time, the hemostasis method of manual compression is the only choice of the operator. However, manual pressing is long in time consumption, occupies medical care resources, is easy to form hematoma, and causes discomfort when a patient presses. With the development of vascular interventional therapy, a thicker catheter sheath and anticoagulant drugs are often needed, and the difficulty of vascular healing is increased. Therefore, in order to reduce the compression and braking time, improve the comfort level of the patient, relieve the hands of medical staff, and assist the treatment method of closing the vascular puncture and achieving hemostasis by the medical instrument. Currently, the common vascular occlusive devices on the market can be divided into active vascular occlusive devices, compression auxiliary occlusive devices and surface hemostatic patches. Active vascular occlusive devices, which actively and directly occlude a puncture using various methods, are widely used clinically. However, the active vascular occluder in the prior art has certain disadvantages:

some active vascular closers require a support device inside the vessel, and although the support device is mostly made of degradable materials in order to avoid residues in the vessel, the support device made of degradable materials also reduces the safety to a certain extent.

Some active vascular closers without supporting devices are anchored by a plugging umbrella, collagen emboli are released in the lower channel of the vascular sheath to obtain hemostasis, and after the operation is finished, the plugging umbrella is retracted, so that foreign matters are not remained in the vascular cavity. However, such active vascular occlusive devices can only close small puncture holes, and cannot be used for larger puncture holes, especially those in arteries.

Some active vascular occlusive devices include an intravascular stent that is covered with a membrane at the puncture site and supported by a frame at the remaining site, which can close the puncture due to the thicker sheath puncture, but because of the intravascular stent, it remains permanently in the body, risking thrombus, and can affect the second puncture.

Some active vascular closers take the form of staples/clips, but such active vascular closers are only used for smaller puncture holes of 5-8F, and cannot close larger hole sizes.

Disclosure of Invention

The invention aims to provide a vascular closure device, a vascular closure system and an operation method of the vascular closure system, so as to solve the problem that the existing vascular closure device cannot achieve both large aperture and high reliability.

In order to solve the above technical problems, the present invention provides a vascular closer, comprising: a gripper and a wire guide needle;

one end of the gripper is provided with a coil; the lead wire needle is used for being detachably connected with the closed wire assembly and used for driving a part of the closed wire assembly to penetrate into the coil and then be separated from the closed wire assembly;

the gripper is configured to move axially along itself to pull the closure wire assembly through the coil, causing the closure wire assembly to retract a target object to be closed.

Optionally, the vascular closer comprises at least two lead pins and at least two coils, wherein the at least two lead pins are circumferentially distributed around the grabber, and the circumferential positions of the coils on the grabber are in one-to-one correspondence with the lead pins.

Optionally, the vascular closer comprises a base tube extending along the axial direction of the grabber, and the grabber and the lead needle are respectively and movably penetrated in the base tube along the axial direction of the base tube.

Optionally, the base pipe includes a closed line cavity opened along an axial direction, and the closed line cavity is used for accommodating a part of the closed line assembly therein.

Optionally, the base pipe includes a filling cavity axially opened, and the filling cavity is annularly disposed around the gripper.

Optionally, the lead needle has a limiting portion for limiting displacement of the closed wire assembly in a direction penetrating the coil, but not limiting displacement of the closed wire assembly in a direction penetrating the coil.

Optionally, the limit portion has an abutment cone or latch that contracts toward a direction of penetrating the coil.

In order to solve the technical problem, the invention also provides a vascular closure system, which comprises the vascular closure device and a closure line assembly;

the closed wire assembly includes a connected indwelling portion having an outer dimension greater than a radially outer dimension of the guidewire needle and a closed wire for detachable connection with the guidewire needle and for retraction by the coil.

Optionally, the closing line assembly includes a sleeve, the sleeve with the closing line is kept away from the one end of portion of keeping somewhere, the sleeve is used for detachably the cover to locate on the butt awl of vascular closure.

Optionally, the closure wire is configured to be coiled around a latch of the vascular closure.

To solve the above technical problem, the present invention also provides a method for operating a vascular closure system as described above, the method for operating a vascular closure system comprising:

penetrating one end of the gripper with the coil into a target object to be closed;

driving a part of the closed wire assembly to pass through an anchoring part on the periphery of the target object by the lead wire needle and penetrate into the coil;

separating the lead needle from the closed wire assembly;

the gripper is driven to move in a direction away from the target object, the closing line is retracted and pulled through the coil, one end, away from the retaining portion, of the closing line is driven to penetrate out of the target object, the retaining portion is abutted to the outer wall of the anchoring portion, and accordingly the closing line assembly is retracted and pulled to the target object.

Optionally, after the closing line assembly forms the retraction on the target object, the operation method of the vascular closing system further includes: and filling hemostatic drugs into the target object.

In summary, in the vascular closer, the vascular closure system and the operation method of the vascular closure system provided by the invention, the vascular closer comprises a gripper and a lead needle; one end of the gripper is provided with a coil; the lead wire needle is used for being detachably connected with the closed wire assembly and used for driving a part of the closed wire assembly to penetrate into the coil and then be separated from the closed wire assembly; the gripper is configured to move axially along itself to pull the closure wire assembly through the coil, causing the closure wire assembly to retract a target object to be closed.

So configured, by driving the lead wire needle, a portion of the closed wire assembly can be threaded into the coil; and then drive the grabber, utilize the coil on it to pull the closed line subassembly, and then make the closed line subassembly receive and draw the target object that waits to seal, be applicable to the puncture of various apertures on the one hand, on the other hand utilize the closed line subassembly to seal the puncture, no residue or degradable thing remain, fully guarantee security and reliability.

Drawings

Those of ordinary skill in the art will appreciate that the figures are provided for a better understanding of the present invention and do not constitute any limitation on the scope of the present invention. Wherein:

FIG. 1 is a schematic view of a vascular closure system according to an embodiment of the present invention;

FIG. 2 is a partial cross-sectional view of a vascular closure system according to an embodiment of the present invention;

FIG. 3 is a schematic view of a gripper and coil penetrating a puncture according to an embodiment of the present invention;

FIG. 4 is a schematic view of a needle and wire assembly penetrating a coil according to an embodiment of the present invention;

FIG. 5 is a schematic illustration of a wire guide needle separated from a closed wire assembly according to an embodiment of the present invention;

FIG. 6 is a schematic diagram of a gripper beginning retraction according to an embodiment of the present invention;

FIG. 7 is a schematic view of a gripper of an embodiment of the present invention pulling a closure wire assembly through a coil;

FIG. 8 is a schematic view of an indwelling portion abutting the outer periphery of a blood vessel wall according to an embodiment of the present invention;

FIG. 9 is a schematic illustration of an embodiment of the present invention after filling with hemostatic drug;

FIG. 10 is a schematic view of a sleeve according to an embodiment of the present invention sleeved on an abutment cone;

FIG. 11 is a schematic illustration of a closed wire wrapped around a latch according to an embodiment of the present invention.

In the accompanying drawings:

1-vascular occluder; 10-base pipe; 101-a gripper cavity; 102-a guidewire needle lumen; 103-closing the linear cavity; 104-filling the cavity; 11-a gripper; 110-body; a 111-coil; 12-a lead wire needle; 121-an abutment cone; 122-latch; a 2-closure line assembly; 21-an indwelling part; 22-a closed line; 23-sleeve; 3-blood vessel; 31-vessel wall; 32-puncturing holes; 33-subcutaneous tissue; 34-skin; 35-collagen; 36-anchoring holes.

Detailed Description

The invention will be described in further detail with reference to the drawings and the specific embodiments thereof in order to make the objects, advantages and features of the invention more apparent. It should be noted that the drawings are in a very simplified form and are not drawn to scale, merely for convenience and clarity in aiding in the description of embodiments of the invention. Furthermore, the structures shown in the drawings are often part of actual structures. In particular, the drawings are shown with different emphasis instead being placed upon illustrating the various embodiments.

As used in this disclosure, the singular forms "a," "an," and "the" include plural referents, the term "or" are generally used in the sense of comprising "and/or" and the term "several" are generally used in the sense of comprising "at least one," the term "at least two" are generally used in the sense of comprising "two or more," and the term "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying any relative importance or number of features indicated. Thus, a feature defining "first," "second," "third," or the like, may explicitly or implicitly include one or at least two such features, with "one end" and "another end" and "proximal end" and "distal end" generally referring to the corresponding two portions, including not only the endpoints. The terms "proximal" and "distal" are defined herein with respect to a vascular closure having one end for intervention in a human body and a manipulation end extending outside the body. The term "proximal" refers to the position of the element closer to the manipulation end of the vascular closure that extends outside the body, and the term "distal" refers to the position of the element closer to the end of the vascular closure that is to be introduced into the body and thus further from the manipulation end of the vascular closure. Alternatively, in a manual or hand-operated application scenario, the terms "proximal" and "distal" are defined herein with respect to an operator, such as a surgeon or clinician. The term "proximal" refers to a location of an element that is closer to the operator, and the term "distal" refers to a location of an element that is closer to the vascular occluder and thus further from the operator. Furthermore, as used in this disclosure, "mounted," "connected," and "disposed" with respect to another element should be construed broadly to mean generally only that there is a connection, coupling, mating or transmitting relationship between the two elements, and that there may be a direct connection, coupling, mating or transmitting relationship between the two elements or indirectly through intervening elements, and that no spatial relationship between the two elements is to be understood or implied, i.e., that an element may be in any orientation, such as internal, external, above, below, or to one side, of the other element unless the context clearly dictates otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances. Furthermore, directional terms, such as above, below, upper, lower, upward, downward, left, right, etc., are used with respect to the exemplary embodiments as they are shown in the drawings, upward or upward toward the top of the corresponding drawing, downward or downward toward the bottom of the corresponding drawing.

The invention aims to provide a vascular closure device, a vascular closure system and an operation method of the vascular closure system, so as to solve the problem that the existing vascular closure device cannot achieve both large aperture and high reliability.

The following description refers to the accompanying drawings.

Referring to fig. 1, an embodiment of the present invention provides a vascular closure system comprising a vascular closure 1 and a closure wire assembly 2, the vascular closure system being adapted for closing a target object (e.g. a puncture). In use, one end of the closing wire assembly 2 can be penetrated into the puncture hole by using the vascular closer 1, and then the closing wire assembly 2 is pulled out of the puncture hole by using the vascular closer 1, so that the puncture hole to be closed is formed by using the closing wire assembly 2, and the puncture hole is reduced or closed. The device is suitable for the puncture holes with various apertures on one hand, and on the other hand, the puncture holes are closed by utilizing the closed line assembly 2, so that no residue or degradable residue exists, and the safety and the reliability are fully ensured.

The vascular closure system can be applied to a surgical scene for closing a puncture hole of a blood vessel of an artery or vein. However, it should be understood that the vascular closure system provided in this embodiment is not limited to application in an actual surgical scenario, and the target object may be configured as a puncture hole on a vascular prosthesis model, for example, the vascular closure system may be applied to applications such as training an operator or calibrating parameters of the vascular closure system. The puncture hole 32 in the blood vessel 3 will be described as an example.

Referring to fig. 1 to 11, the vascular closer 1 includes: a gripper 11 and a wire guide needle 12; one end of the gripper 11 has a coil 111; the lead wire needle 12 is used for being detachably connected with the closed wire assembly 2 and is used for driving a part of the closed wire assembly 2 to penetrate into the coil 111 and then be separated from the closed wire assembly 2; the gripper 11 is configured to move axially along itself to pull the closing wire assembly 2 through the coil 111, causing the closing wire assembly 2 to retract the puncture hole 32 to be closed.

In an alternative example, the gripper 11 includes a rod-shaped body 110, and the coil 111 is fixed to the distal end of the body 110. Preferably, the coil 111 can be folded but has a predetermined shape, and the coil 111 can be converted to or toward the predetermined shape when not subjected to an external force. The predetermined form of the coil 111 preferably extends in a direction substantially perpendicular to the body 110, and the circumferential position of the predetermined form of the coil 111 around the body 110 is also substantially determined.

Referring to fig. 3, the blood vessel 3 includes a blood vessel wall 31, a puncture hole 32 is formed in the blood vessel wall 31, and the outer side of the blood vessel 3 further includes tissues such as subcutaneous tissue 33 and skin 34. After the distal end of the grasping device 11 is passed through the puncture hole 32 into the blood vessel 3, the coil 111 is deployed and converted to a predetermined shape, and extends in the axial direction of the blood vessel 3.

Referring to fig. 4, optionally, the axial direction of the needle 12 is parallel to the axial direction of the body 110, and the distal end of the needle 12 has a sharp end that can be used to puncture the vessel wall 31 of the blood vessel 3. It should be appreciated that the position where the needle 12 pierces the vessel wall 31 is spaced from the puncture 32. For convenience of description, a portion of the blood vessel 3 corresponding to the puncture position of the needle 12 is referred to as an anchor portion, which is preferably located around the puncture hole 32, and a hole formed by the needle 12 by puncturing is referred to as an anchor hole 36. The closed wire assembly 2, when connected to the needle 12, can be driven by the needle 12 to pass through the anchoring hole 36 together and penetrate into the blood vessel 3. Since the predetermined configuration of the coil 111 is also substantially defined around the circumferential position of the body 110, the needle 12 may be adapted to drive the closure wire assembly 2 through the coil 111 after the needle 12 is inserted into the blood vessel 3 at a certain position.

Further, referring to fig. 5, the needle 12 may be separated from the closed wire assembly 2, for example, by retracting toward the proximal end (upper end in fig. 5), where only the closed wire assembly 2 is left in the coil 111.

Referring to fig. 6 and 7, the gripper 11 moves axially along itself, for example, by retracting proximally, the coil 111 is gradually pulled out of the puncture 32, and the enclosed area of the coil 111 is gradually reduced until one end of the closure wire assembly 2 is pulled proximally and out of the puncture 32. Since the two ends of the closing wire assembly 2 are respectively penetrated into two different holes (one end is penetrated into the penetrating hole 32 and the other end is penetrated into the anchoring hole 36 formed by the penetration of the lead needle 12) of the blood vessel wall 31, the penetrating hole 32 to be closed can be retracted and pulled by pulling the two ends of the closing wire assembly 2, so that the penetrating hole 32 can be reduced or closed.

Preferably, referring to fig. 8 and 10, the closed wire assembly 2 includes a connecting indwelling portion 21 and a closed wire 22, wherein the outer dimension of the indwelling portion 21 is larger than the radial outer dimension of the needle 12, the closed wire 22 is detachably connected to the needle 12, and the closed wire 22 is pulled by the coil 111. When the gripper 11 moves back towards the proximal end and pulls the closing line 22 towards the proximal end to a certain position through the coil 111, the retaining part 21 will abut against the outer wall of the anchoring part, and at this time, retraction of the puncture hole 32 can be realized by only pulling the closing line 22 towards the proximal end, so that the puncture hole 32 is reduced or closed. The indwelling portion 21 may be, for example, an anchor sheet.

Alternatively, referring to fig. 9, after the puncture hole 32 to be closed is retracted by the closing wire assembly 2, a hemostatic drug such as collagen 35 or the like may be filled into the outer periphery of the blood vessel wall 31 at a position corresponding to the puncture hole 32.

Optionally, the vascular closer comprises at least two lead pins 12 and at least two coils 111, at least two lead pins 12 are circumferentially distributed around the gripper 11, and circumferential positions of the coils 111 on the gripper 11 are in one-to-one correspondence with the lead pins 12. The arrangement of at least two lead pins 12 and at least two coils 111 may form at least two anchors around the puncture 32, facilitating uniform closure of the puncture 32. In the exemplary embodiment shown in fig. 1 and 2, the vascular closure comprises four lead pins 12 and four coils 111, the four lead pins 12 being evenly distributed circumferentially around the gripper 11. The predetermined pattern of the four coils 111 is one-to-one corresponding to the pins 12 around the circumferential position of the body 110 to ensure that each pin 12 can penetrate into the corresponding coil 111.

Alternatively, referring to fig. 1 and 2, the vascular closer 1 includes a base tube 10 extending along an axial direction of the gripper 11, and the gripper 11 and the needle 12 are movably disposed through the base tube 10 along the axial direction of the base tube 10, respectively. In an alternative exemplary embodiment, the base pipe 10 is a multi-lumen pipe comprising a centrally located gripper cavity 101, and a needle lumen 102 circumferentially distributed around the gripper cavity 101, the gripper cavity 101 and the needle lumen 102 being parallel to each other. This limits the direction of movement of the gripper 11 and the wire guide 12.

Optionally, the base pipe 10 includes a closed line cavity 103 that is opened in an axial direction, and the closed line cavity 103 is configured to accommodate a portion of the closed line assembly 2 therein. In an alternative example, the closure wire assembly 2 includes a retention portion 21, and the radial dimension of the closure wire lumen 103 is not smaller than the outer dimension of the retention portion 21 to allow the retention portion 21 and a portion of the closure wire 22 to be movably received therein. Preferably, the number of closed wire cavities 103 matches the number of lead wires 12, each lead wire 12 corresponding to a different closed wire assembly 2 and also to a different closed wire cavity 103. For example, in the example shown in fig. 1 and 2, the base pipe 10 includes four closed line lumens 103. The closed line cavity 103 can be used for accommodating the closed line components 2 in the base pipe 10 in a tidying way, so that the generation of mutual winding between the closed line components 2 is reduced or avoided.

Optionally, the base pipe 10 includes an axially opened filling cavity 104, and the filling cavity 104 is annularly disposed around the gripper 11. The filling cavity 104 may contain a certain amount of hemostatic drug (such as collagen 35), and after the puncture hole 32 to be sealed is completely retracted by the closing wire assembly 2, the hemostatic drug in the filling cavity 104 may be pushed out, so that the hemostatic drug can be filled around the puncture hole 32.

Alternatively, referring to fig. 10 and 11, the guide wire needle 12 has a limiting portion for limiting the displacement of the closing wire assembly 2 in the direction of penetrating the coil 111 (i.e., toward the distal end), but not limiting the displacement of the closing wire assembly 2 in the direction of penetrating the coil 111 (i.e., toward the proximal end).

As shown in fig. 10, in some embodiments, the limiting portion has an abutment cone 121 that contracts toward penetrating the coil 111, and the lead wire needle 12 is disposed by the abutment cone 121, so as to achieve connection with the closing wire assembly 2 by abutting, and drive the closing wire assembly 2 to move together toward the distal end. Specifically, the abutment cone 121 is a cone, for example, a cone or a pyramid, the apex of which faces the direction of penetration into the coil 111 (i.e., toward the distal direction), and the bottom surface of which is connected to the main body portion of the lead needle 12. The closed line assembly 2 comprises a sleeve 23, the sleeve 23 is connected with one end of the closed line 22 away from the retaining part 21, and the sleeve 23 is detachably sleeved on the abutment cone 121. It will be appreciated that the tapered surface of abutment taper 121 is capable of abutting sleeve 23 when needle 12 is moved distally, and sleeve 23 is separated from needle 12 when needle 12 is moved proximally because abutment taper 121 no longer abuts against limiting the displacement of sleeve 23. Further, as the needle 12 is moved proximally and withdrawn from the puncture, the sleeve 23 is captured subcutaneously in the puncture due to shrinkage of the puncture due to the sleeve 23 having an outer diameter greater than the outer diameter of the needle 12.

In other embodiments, as shown in fig. 11, the stopper has a latch 122 that is contracted toward a direction penetrating the coil 111, and the closing wire 22 is used to be wound around the latch 122. The needle 12 is connected with the closing wire assembly 2 by the latch 122 in a coiling way for the closing wire 22, and drives the closing wire assembly 2 to move along towards the distal end. At this time, the closing wire assembly 2 may not include the sleeve 23, but only the closing wire 22 is wound around the latch 122, and when the needle 12 moves distally, the latch 122 moves together with the closing wire 22 distally, and when the needle 12 moves proximally, the latch 122 is retracted distally, and is separated from the closing wire 22, so that the displacement of the closing wire 22 is not limited any more.

Of course, the above-mentioned examples shown in fig. 10 and 11 are merely examples of the limiting portion, and those skilled in the art may select other structures of the limiting portion according to the prior art, for example, the limiting portion may be configured as an electrolytic coil, etc., and the closing wire assembly 2 may be fused to be separated from the lead wire 12 by externally controlling the current.

The embodiment of the invention also provides an operation method of the vascular closure system, which is used for operating the vascular closure system, and comprises the following steps:

step S1: penetrating the end of the gripper 11 having the coil 111 into a target object to be closed (i.e., a puncture hole 32);

step S2: bringing the lead wire 12 with a portion of the closed wire assembly 2 (mainly the closed wire 22, optionally including the sleeve 23) through an anchoring portion of the periphery of the target object (i.e., piercing to form an anchoring hole 36, and passing through the anchoring hole 36), and penetrating the coil 111;

step S3: separating the lead needle 12 from the closure wire assembly 2 (e.g., from the closure wire 22 or sleeve 23);

step S4: the gripper 11 is driven to move in a direction away from the target object (i.e. to a distal end), the closing wire 22 is retracted by the coil 111, one end of the closing wire 22 away from the retaining portion 21 is driven to penetrate out of the target object, and the retaining portion 21 is abutted against the outer wall of the anchoring portion, so that the closing wire assembly 2 forms retraction on the target object.

Further, after the closing line assembly 2 is retracted and pulled to the target object in step S4, the operation method of the vascular closing system further includes: step S5: hemostatic drugs (e.g., collagen 35) are administered to the subject.

It should be understood that the operation method of the vascular closure system provided in this embodiment is not limited to application in an actual surgical scenario, and the target object may be configured as a puncture hole on a vascular prosthesis model, for example, the operation method of the vascular closure system may be applied to applications such as training an operator or calibrating parameters of the vascular closure system.

In summary, in the vascular closer, the vascular closure system and the operation method of the vascular closure system provided by the invention, the vascular closer comprises a gripper and a lead needle; one end of the gripper is provided with a coil; the lead wire needle is used for being detachably connected with the closed wire assembly and used for driving a part of the closed wire assembly to penetrate into the coil and then be separated from the closed wire assembly; the gripper is configured to move axially along itself to pull the closure wire assembly through the coil, causing the closure wire assembly to retract a target object to be closed. So configured, by driving the lead wire needle, a portion of the closed wire assembly can be threaded into the coil; and then drive the grabber, utilize the coil on it to pull the closed line subassembly, and then make the closed line subassembly receive and draw the target object that waits to seal, be applicable to the puncture of various apertures on the one hand, on the other hand utilize the closed line subassembly to seal the puncture, no residue or degradable thing remain, fully guarantee security and reliability.

It should be noted that the above embodiments may be combined with each other. The above description is only illustrative of the preferred embodiments of the present invention and is not intended to limit the scope of the present invention, and any alterations and modifications made by those skilled in the art based on the above disclosure shall fall within the scope of the appended claims.

Claims (12)

1. A vascular closure, comprising: a gripper and a wire guide needle;

one end of the gripper is provided with a coil; the lead wire needle is used for being detachably connected with the closed wire assembly and used for driving a part of the closed wire assembly to penetrate into the coil and then be separated from the closed wire assembly;

the gripper is configured to move axially along itself to pull the closure wire assembly through the coil, causing the closure wire assembly to retract a target object to be closed.

2. The vascular closure according to claim 1, wherein the vascular closure comprises at least two of the lead pins and at least two of the coils, the at least two of the lead pins being circumferentially distributed around the gripper, the circumferential positions of the coils on the gripper being in one-to-one correspondence with the lead pins.

3. The vascular closure according to claim 1, wherein the vascular closure comprises a base tube extending in an axial direction of the gripper, the gripper and the needle being movably penetrating the base tube in the axial direction of the base tube, respectively.

4. The vascular occluder of claim 3, wherein the base tube comprises an axially open closed wire lumen for receiving a portion of the closed wire assembly therein.

5. The vascular closure of claim 3, wherein the base tube includes an axially-open filling lumen disposed annularly about the grasper.

6. The vascular closer of claim 1 wherein the lead needle has a stop for limiting displacement of the closing wire assembly in a direction into the coil but not limiting displacement of the closing wire assembly in a direction out of the coil.

7. The vascular occluder of claim 6, wherein the stop has an abutment cone or latch that contracts toward penetrating the coil.

8. A vascular closure system comprising a vascular closure as claimed in any one of claims 1 to 7, further comprising a closure wire assembly;

the closed wire assembly includes a connected indwelling portion having an outer dimension greater than a radially outer dimension of the guidewire needle and a closed wire for detachable connection with the guidewire needle and for retraction by the coil.

9. The vascular closure system of claim 8, wherein the closure wire assembly includes a sleeve connected to an end of the closure wire distal from the indwelling portion, the sleeve being adapted to detachably fit over an abutment cone of the vascular closure.

10. The vascular closure system according to claim 8, wherein the closure wire is adapted to be coiled around a latch of the vascular closure.

11. A method of operating a vascular closure system according to any one of claims 8 to 10, comprising:

penetrating one end of the gripper with the coil into a target object to be closed;

driving a part of the closed wire assembly to pass through an anchoring part on the periphery of the target object by the lead wire needle and penetrate into the coil;

separating the lead needle from the closed wire assembly;

the gripper is driven to move in a direction away from the target object, the closing line is retracted and pulled through the coil, one end, away from the retaining portion, of the closing line is driven to penetrate out of the target object, the retaining portion is abutted to the outer wall of the anchoring portion, and accordingly the closing line assembly is retracted and pulled to the target object.

12. The method of claim 11, wherein after the closing wire assembly is retracted to the target object, the method of operating a vascular closure system further comprises: and filling hemostatic drugs into the target object.

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