CN116068215A

CN116068215A - Pipetting device and sample preparation device

Info

Publication number: CN116068215A
Application number: CN202210764623.0A
Authority: CN
Inventors: 吴晓斌; 涂元
Original assignee: MGI Tech Co Ltd
Current assignee: MGI Tech Co Ltd
Priority date: 2021-10-29
Filing date: 2022-06-30
Publication date: 2023-05-05
Also published as: CN217527540U; CN217901338U; CN116068214A

Abstract

The invention provides a pipetting device and a sample preparation device, wherein the pipetting device comprises: the first cross beam and the second cross beam are oppositely arranged, and an installation space is reserved between the first cross beam and the second cross beam; the first pipetting structure and the second pipetting structure are both arranged in the installation space, the first pipetting structure comprises a plurality of first pipettors which are movably arranged on the first cross beam along the horizontal direction, the second pipetting structure comprises second pipettors which are movably arranged on the second cross beam along the horizontal direction, and gun head adapters of each first pipetting structure and gun head adapters of the second pipetting structure are arranged in a row. By applying the technical scheme of the invention, the problem of low sample preparation efficiency of the pipetting device in the related technology can be effectively solved.

Description

Pipetting device and sample preparation device

RELATED APPLICATIONS

The present application claims priority to the patent office of China, application No. 202111270792.0, entitled "automated sample preparation System", filed on Japan 10, 29 of 2021, the entire contents of which are incorporated herein by reference.

Technical Field

The invention relates to the field of sample preparation devices, in particular to a pipetting device and a sample preparation device.

Background

A pipette is a device for quantitatively sucking and quantitatively discharging liquid, and is commonly used for pipetting small or trace amounts of liquid in a laboratory. The pipetting device in the related art generally includes a plurality of pipettes, and a disposable gun head is connected to a gun head adapter of each pipette, and when the liquid is sucked, each disposable gun head correspondingly extends into a sample container (deep hole plate) filled with the sample, and the plurality of pipettes on the pipetting device can simultaneously perform pipetting operation on a plurality of samples, so as to improve the preparation efficiency of the samples.

Currently, a plurality of pipettes on a pipetting device in the related art generally include a plurality of rows and columns, and correspondingly, a plurality of gun head adapters on the plurality of pipettes are also provided in a plurality of rows and columns arrangement. At present, the operation habit of an operator is to fill samples in a deep hole plate row by row, if the pipettor is arranged in a mode of multiple rows and multiple columns, which is not beneficial to the matching of the samples and the gun head adapter, the operator is required to change the original installation habit, and the filling position of the samples is adjusted according to the arrangement mode of the gun head adapter, so that the preparation efficiency of the samples can be improved at maximum efficiency. Once the operator changes the operation habit, the probability of error in the sample preparation process is easily improved, and if the filling position of the sample is not adjusted according to the arrangement mode of the gun head adapter, the sample preparation efficiency of the pipetting device can be affected.

Disclosure of Invention

The invention mainly aims to provide a pipetting device and a sample preparation device, which are used for solving the problem of low sample preparation efficiency of the pipetting device in the related art.

In order to achieve the above object, according to one aspect of the present invention, there is provided a pipetting device comprising: the first cross beam and the second cross beam are oppositely arranged, and an installation space is reserved between the first cross beam and the second cross beam; the first pipetting structure and the second pipetting structure are both arranged in the installation space, the first pipetting structure comprises at least one first pipetting device which is movably arranged on the first cross beam along the horizontal direction, the second pipetting structure comprises at least one second pipetting device which is movably arranged on the second cross beam along the horizontal direction, gun head adapters are arranged on each first pipetting device and each second pipetting device, and gun head adapters of each first pipetting device are arranged in a row with gun head adapters of the second pipetting devices.

Further, at least one first pipettor is spaced from at least one second pipettor.

Further, the first pipettor and the second pipettor each comprise: the sleeve assembly comprises a sleeve and a plunger arranged in the sleeve, a liquid transferring cavity is formed in the sleeve, and the plunger is movably arranged in the liquid transferring cavity; the gun head adapter is used for connecting a gun head, the gun head adapter is connected to the sleeve assembly, a first channel is arranged in the gun head adapter, and the first channel is communicated with the pipetting cavity; the connecting crank arm is arranged between the gun head adapter and the sleeve assembly, a second channel is arranged in the connecting crank arm, and the second channel is communicated with the first channel and the pipetting cavity.

Further, be provided with first slide rail on the first crossbeam, pipetting device still includes: the mounting seat is arranged on the first cross beam in a sliding manner, and the first pipetting structure is arranged on the mounting seat; the driving structure is arranged between the first cross beam and the mounting seat to drive the mounting seat to move on the first cross beam.

Further, the mounting seat comprises a plurality of connecting plates which are connected with the plurality of first pipettes in a one-to-one correspondence manner, and each connecting plate is slidably arranged on the first sliding rail; the driving structure comprises a toothed belt and a plurality of first motors, the machine body of each first motor is connected with a connecting plate, the toothed belt is arranged on the first cross beam, a gear sleeve is fixedly arranged on the rotating shaft of each first motor, and the gear sleeve on each first motor is meshed with the toothed belt.

Further, the rack belt comprises a first belt body and a second belt body which are arranged at intervals along the height direction of the first cross beam, and gear sleeves in two first motors which are arranged arbitrarily adjacently are respectively connected with the first belt body and the second belt body in a meshed mode.

Further, two ends of the first belt body are respectively fixed at two opposite ends of the first cross beam, two tensioning wheels which are parallel to the rotating shaft are further arranged on each first motor, the axis of the rotating shaft of the first motor and the axes of the two tensioning wheels form a triangle structure, the first belt body is wound on the gear sleeve and the two tensioning wheels, the gear sleeve is meshed with the toothed surface of the first belt body, and the two tensioning wheels are matched with the non-toothed surface of the first belt body.

Further, the first pipettor is movably arranged on the connecting plate along the vertical direction.

Further, be provided with the second slide rail that extends along vertical direction on the connecting plate, be provided with on the first pipettor with second slide rail sliding connection's slider, pipetting device is still including setting up the second motor on the connecting plate, and the second motor includes the lead screw, and in the lead screw was worn to locate the slider, be provided with the screw hole that sets up with the lead screw cooperation in the slider.

Further, the pipetting device further comprises: the first cross beam and the second cross beam are arranged on the frame; the first cantilever and the second cantilever are arranged on the frame, the first cantilever is provided with first position sensors which are arranged in one-to-one correspondence with the plurality of first pipettors, and the second cantilever is provided with second position sensors which are arranged in correspondence with the second pipettors.

Further, the pipetting device further comprises: the grabbing mechanical arm is slidably arranged on the side wall, far away from the first pipettor, of the first cross beam and comprises a rotating clamping jaw.

According to another aspect of the present invention, there is also provided a sample preparation device comprising: and the pipetting device is the pipetting device.

By applying the technical scheme of the invention, the installation space for installing a plurality of first pipettes and second pipettes is formed between the first beam and the second beam, the main body part of the first pipettes is connected to the first beam in a sliding way, the main body part of the second pipettes is connected to the second beam, and the gun head adapter of each first pipettor and the gun head adapter of the second pipettor are arranged in a row. The arrangement mode divides the main body part of the first pipettors and the main body part of the second pipettors into two rows, simultaneously enables the gun head adapters of the first pipettors and the second pipettors to be arranged in a row, can inject samples into the deep hole plate row by row when injecting the samples into the deep hole plate, and enables the gun head adapters arranged in a row to operate the solution in the deep hole plate row by row, so that the situation that the pipettors are empty is avoided, and the processing efficiency of the samples is improved. Adopt the mode of setting up of pipetting structure of this application, can promote the cooperation degree of pipetting device and consumptive material, operating personnel need not to change original operating habit, has reduced operating personnel's probability of making mistakes at sample handling process to user's use experience has been promoted.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention. In the drawings:

fig. 1 shows a schematic perspective view of an embodiment of a pipetting device according to the invention;

fig. 2 is a schematic perspective view showing a part of the construction of the pipetting device of fig. 1;

FIG. 3 shows a schematic view of the mounting structure of the first pipette, the connection plate, the first motor, and the second motor of the pipetting device of FIG. 1;

FIG. 4 shows a schematic distribution of a plurality of connecting arms and a plurality of gun head adapters of the pipetting device of FIG. 1; and

fig. 5 shows a schematic partial structure of the pipetting device of fig. 1.

Wherein the above figures include the following reference numerals:

1. an installation space; l, presetting a straight line; 10. a first cross beam; 20. a second cross beam;

30. a first pipette; 31. a sleeve assembly; 32. a gun head adapter; 33. connecting the crank arms; 34. a slide block;

40. a second pipettor; 50. a connecting plate; 51. a second slide rail;

60. a driving structure; 61. a toothed strip; 611. a first belt body; 612. a second belt body; 62. a first motor; 63. a gear sleeve; 64. a tensioning wheel;

70. a second motor; 71. a screw rod; 80. a frame; 90. a first cantilever; 100. a second cantilever; 110. and grabbing the mechanical arm.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

The relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective parts shown in the drawings are not drawn in actual scale for convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but should be considered part of the specification where appropriate. In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.

After long-term research, the inventor finds that the low sample preparation efficiency of the current pipetting device is caused by poor matching of the arrangement mode of a plurality of gun head adapters on the pipetting device with consumable materials such as a deep hole plate, a disposable gun head accommodating box and the like. In particular, the plurality of gun head adapters on current pipettes are provided in a multi-row, multi-column arrangement. At present, the operation habit of an operator is to fill samples in a deep hole plate row by row, if the pipettor is arranged in a mode of multiple rows and multiple columns, which is not beneficial to the matching of the samples and the gun head adapter, the operator is required to change the original installation habit, and the filling position of the samples is adjusted according to the arrangement mode of the gun head adapter, so that the preparation efficiency of the samples can be improved at maximum efficiency. To solve the above-mentioned problems, the present application provides an embodiment of a pipetting device, specifically:

as shown in fig. 1 and 2, the pipetting device of the present embodiment includes: the first cross beam 10, the second cross beam 20, the first pipetting structure and the second pipetting structure. Wherein the first beam 10 and the second beam 20 are oppositely arranged, and an installation space 1 is arranged between the first beam 10 and the second beam 20; the first pipetting structure and the second pipetting structure are both arranged in the installation space 1, the first pipetting structure comprises at least one first pipetting device 30 which is movably arranged on the first cross beam 10 along the horizontal direction, the second pipetting structure comprises at least one second pipetting device 40 which is movably arranged on the second cross beam 20 along the horizontal direction, gun head adapters are arranged on each of the first pipetting device 30 and the second pipetting device 40, and gun head adapters of each of the first pipetting devices 30 are arranged in a row with gun head adapters of the second pipetting device 40.

By applying the technical scheme of the embodiment, a mounting space 1 for mounting a plurality of first pipettes and second pipettes is formed between the first beam 10 and the second beam 20, the main body part of the first pipettes 30 is slidingly connected to the first beam 10, the main body part of the second pipettes is connected to the second beam 20, and the gun head adapter of each first pipettes 30 and the gun head adapter of the second pipettes 40 are arranged in a row. The arrangement mode divides the main body part of the first pipettes 30 and the main body part of the second pipettes 40 into two rows, simultaneously enables the gun head adapters of the first pipettes 30 and the second pipettes 40 to be arranged in a row, can inject samples into the deep hole plate row by row when injecting the samples into the deep hole plate, and enables the gun head adapters arranged in a row to operate the solution in the deep hole plate row by row, so that the situation that the pipettes are empty is avoided, and the processing efficiency of the samples is improved. Adopt the mode of setting up of pipetting structure of this application, can promote the cooperation degree of pipetting device and consumptive material, operating personnel need not to change original operating habit, has reduced operating personnel's probability of making mistakes at sample handling process to user's use experience has been promoted. As shown in fig. 2 to 4, in the present embodiment, there are a plurality of second pipettes 40, and the gun head adapter of each first pipette 30 is located between the gun head adapters of two adjacent second pipettes 40. In the above-described configuration, among the plurality of gun head adapters arranged in a row, the gun head adapter of one first pipette 30 and the gun head adapter of one second pipette 40 are alternately arranged, which is advantageous in improving the compactness of the plurality of gun head adapters.

Specifically, the first pipetting structure of this embodiment includes four first pipettes 30 slidably connected to the first beam 10, and the first pipetting structure includes four second pipettes 40 slidably connected to the second beam 20, so that the gun head adapter includes eight arranged in a row. The consumables commonly used at present comprise a deep hole plate and a disposable gun head in a box. The liquid storage holes on the deep hole plate generally comprise twelve rows of eight, and the eight rows are just matched with eight gun head adapters arranged in one row. The disposable gun tips typically comprise ten rows of eight, just as well as eight gun tip adapters arranged in a row. Because the two adjacent liquid storage holes in the same row on the deep hole plate are provided with smaller intervals, correspondingly, the two adjacent disposable gun heads in the same row are provided with smaller intervals, so that the two adjacent gun head adapters are required to be provided with smaller intervals, and each disposable gun head can be matched with the liquid storage hole or the disposable gun head in the same row.

It should be noted that, the above four first pipettes 30 and four second pipettes that are independently set may meet the requirement of the user for flexibly preparing multiple samples, when the user uses, 1 or more pipettes may be configured and used according to the type and number of sample preparation, and the two rows of pipettes may move independently, so that the user may conveniently and flexibly prepare sample experiments, and may adapt to multiple application scenarios.

In order to enhance the degree of fit of the plurality of tip adapters with the liquid storage hole and the disposable tip, as shown in fig. 4, in the present embodiment, the minimum interval between the two tip adapters of the first pipette 30 and the second pipette 40 disposed adjacently is between 8mm and 12 mm. Preferably, in the present embodiment, the spacing between the two gun head adapters of the first and

second pipettes

30, 40 is 9mm. Of course, the interval may be 8mm, 10mm, or the like.

The "interval between two gun head adapters" mentioned above refers to the distance between the center lines of two adjacent gun head adapters.

As shown in fig. 3, in the present embodiment, the first pipetter 30 and the second pipetter 40 each include: sleeve assembly 31, gun head adapter 32 and connecting lever 33. The sleeve assembly 31 comprises a sleeve and a plunger arranged in the sleeve, a liquid transferring cavity is formed in the sleeve, and the plunger is movably arranged in the liquid transferring cavity; the gun head adapter 32 is used for connecting a gun head, the gun head adapter 32 is connected to the sleeve assembly 31, a first channel is formed in the gun head adapter 32, and the first channel is communicated with the pipetting cavity; the connecting crank arm 33 is arranged between the gun head adapter 32 and the sleeve assembly 31, and a second channel is arranged in the connecting crank arm 33 and is communicated with the first channel and the pipetting cavity. In the above-mentioned structure, sleeve subassembly 31 arranges into two rows and sets up, and rifle head adapter 32 arranges into one row and sets up, connects turning arm 33 can communicate sleeve subassembly 31 and rifle head adapter 32, can make the setting position of rifle head adapter 32 more nimble through setting up and connect turning arm 33 to on the one hand can realize the scheme that a plurality of rifle head adapters 32 arrange into one row, on the other hand makes the compacter that a plurality of rifle head adapters 32 can set up, has effectively shortened the distance between two adjacent rifle head adapters 32.

It should be noted that, the arrangement modes of the eight gun head adapters include two modes, and the first mode is as the arrangement mode of the present embodiment: the gun head adapter of one first pipette 30 and the gun head adapter of one second pipette 40 are alternately arranged as shown in fig. 4. The second arrangement is that the four gun head adapters of the four first pipettes 30 are arranged together, and then the four gun head adapters of the four second pipettes 40 are arranged, so that if the second arrangement is adopted, the connecting crank arm of the pipette at the outer end needs to be set to be longer, and the length of the liquid circulation channel in the pipette is increased, so that the pipetting accuracy of the pipette is affected. The gun head adapter of the first pipette 30 and the gun head adapter of the second pipette 40 are alternately arranged, so that the length of the connecting crank arm of the pipette positioned at the outer end can be shortened, and the pipetting accuracy of the pipette can be improved.

As shown in fig. 4, in the present embodiment, the gun head adapters 32 of each first pipette 30 are arranged in a row along the extending direction of the preset straight line L, the plurality of connecting arms 33 of the plurality of first pipettes 30 include two outer connecting blocks and two inner connecting arms 33 located between the two outer connecting arms 33, and a first angle α between the extending direction of the outer connecting arms 33 and the extending direction of the preset straight line L is smaller than a second angle β between the extending direction of the inner connecting arms 33 and the extending direction of the preset straight line L. The above structure can make the gun head adapters 32 arranged in a row be positioned in the middle of the area surrounded by the plurality of sleeve assemblies 31, thereby being beneficial to shortening the set length of the connecting crank arms 33 and improving the pipetting accuracy of the first pipettes 30 and the second pipettes 40. Specifically, the first and

second pipettes

30, 40 each include a sleeve assembly 31, the sleeve assembly 31 including a sleeve having a pipetting chamber therein and a plunger disposed within the sleeve, the plunger being movably disposed within the pipetting chamber. The core principle of the pipettor is as follows: the air pressure in the pipetting chamber is changed by the movement of the plunger, so that the liquid sample can enter the pipetting chamber or be released from the pipetting chamber. Since air is compressible, the density of the air may be changed by compression or dilution with the movement of the piston, and the change in the density of the air may cause a change in the volume of the liquid actually introduced into or discharged from the pipetting chamber with the distance of the plunger movement being constant, which is a key factor affecting pipetting accuracy of the pipetting device. Therefore, the shorter the length and the smaller the volume of the channel in the pipette are, the more favorable for improving the pipetting accuracy of the pipette. The adoption of the setting mode can be favorable for shortening the setting length of the connecting crank arm 33 and improving the pipetting accuracy of the first pipettor and the second pipettor.

As shown in fig. 4, the extending direction of the connecting lever refers to the connecting line direction between the mounting hole of the gun head adapter on the connecting lever and the communicating hole of the pipetting chamber.

As shown in fig. 2, 3 and 5, in this embodiment, the first beam 10 is provided with a first sliding rail, and the pipetting device further includes: a mounting base and a driving structure 60, wherein the mounting base is arranged on the first cross beam 10 in a sliding manner, and the first pipetting structure is arranged on the mounting base; the driving structure 60 is disposed between the first beam 10 and the mounting base to drive the mounting base to move on the first beam 10. In the above structure, the mounting seat is slidably disposed on the first beam 10, and the first pipetting structure is connected to the mounting seat to realize sliding on the first beam 10. The driving structure 60 can drive the installation seat to slide on the first cross beam 10, so that the automation degree of the pipetting device is improved. The second pipetting structure is arranged in substantially the same manner as the first pipetting structure.

As shown in fig. 2, 3 and 5, in the present embodiment, the mounting base includes a plurality of connection plates 50 connected in one-to-one correspondence with the plurality of first pipettes 30, each connection plate 50 being slidably disposed on the first slide rail; the driving structure 60 comprises a toothed belt 61 and a plurality of first motors 62, the machine body of each first motor 62 is connected with one connecting plate 50, the toothed belt 61 is arranged on the first cross beam 10, a gear sleeve 63 is fixedly arranged on the rotating shaft of each first motor 62, and the gear sleeve 63 on each first motor 62 is meshed with the toothed belt 61. In the above-described structure, the movement of each first pipette 30 is independently driven by the corresponding first motor 62. Accordingly, each second pipettor 40 is driven in the same manner as each first pipettor 30. The driving mode enables the movement of the first pipettor 30 and the second pipettor 40 to be more flexible, only a part of the first pipettor 30 or a part of the second pipettor 40 can be driven to be used, and the distance between two adjacent first pipettors 30 and second pipettors 40 can be adjusted through the structure, so that the pipetting device can adapt to richer working conditions, and the universality of the pipetting device is improved.

As shown in fig. 2, 3 and 5, in the present embodiment, the first motor 62 is provided on the side wall of the connection plate 50 away from the first pipettor 30, and the rack belt 61 is provided on the side wall of the first cross member 10 away from the first pipettor 30. In the above structure, the height of the connecting plate 50 is higher than that of the first beam 10, the first side surface of the connecting plate 50 is slidably connected with the first beam 10, and meanwhile, a first motor 62 is further disposed on the first side surface, the first motor 62 is disposed on a portion of the connecting plate 50 higher than the first beam 10, a pivot shaft of the first motor extends downward, and a gear sleeve 63 sleeved on the pivot shaft is engaged with a rack belt 61 fixed on the first beam 10. The design layout of the pipetting device can be optimized by the arrangement mode, so that the pipetting device is more compact in structure.

As shown in fig. 5, in the present embodiment, the toothed belt 61 includes a first belt body 611 and a second belt body 612 that are disposed at intervals in the height direction of the first cross member 10, and the gear sleeves 63 in any two first motors 62 disposed adjacently are respectively engaged with the first belt body 611 and the second belt body 612. The above structure can avoid the mutual interference of two adjacent first motors 62 in the driving process, in addition, the first belt body 611 is in driving fit with one part of the first motors 62, and the second belt body 612 is in driving fit with the other part of the first motors 62, so that the stress of the gear sleeve 63 borne by the first belt body 611 and the second belt body 612 respectively can be reduced, and the service life of the toothed belt 61 is prolonged. Accordingly, the second pipettor 40 is driven in the same manner as the first pipettor 30.

As shown in fig. 5, in this embodiment, two ends of the first belt body 611 are respectively fixed at two opposite ends of the first beam 10, two tensioning wheels 64 parallel to the rotating shaft are further disposed on each first motor 62, the axis of the rotating shaft of the first motor 62 and the axes of the two tensioning wheels 64 form a triangle structure, the first belt body 611 is wound on the gear sleeve 63 and the two tensioning wheels 64, the gear sleeve 63 is meshed with the toothed surface of the first belt body 611, and the two tensioning wheels 64 are matched with the non-toothed surface of the first belt body 611. In the above structure, the first belt body 611 is a flexible belt, when the first belt body 611 passes through between the first tensioning wheel 64 and the gear sleeve 63 during installation, and passes through between the gear sleeve 63 and the other tensioning wheel 64, so that the first belt body 611 is meshed with the toothed surface of the gear sleeve 63, the non-toothed surface of the first belt body 611 is matched with the two tensioning wheels 64, the reliability of the meshing of the gear sleeve 63 and the first belt body 611 can be improved, and the probability of the gear sleeve 63 being separated from the rack on the first belt body 611 in the rotating process is reduced. Accordingly, the second belt 612 is engaged with the gear sleeve 63 and the tension pulley 64 in the same manner as the first belt 611 is engaged with the gear sleeve 63 and the tension pulley 64.

As shown in fig. 5, in the present embodiment, the distance between the two tension pulleys 64 is smaller than the outer diameter of the gear sleeve 63. The above structure can increase the wrap angle between the first belt body 611 and the gear sleeve 63, thereby increasing the contact area between the first belt body 611 and the gear sleeve 63 and improving the stability of the first belt body 611 and the gear sleeve 63.

As shown in fig. 3, in the present embodiment, the first pipettor 30 is movably provided on the connection plate 50 in the vertical direction. The above structure can facilitate the first pipettor 30 to remove liquid. In addition, the first pipette 30 can move in the vertical direction, so that the gun head adapter gradually moves downwards in the process of sucking liquid again, the lower end face of the gun head adapter always keeps a preset distance from the liquid level of the liquid sample, the volume of the liquid sample attached to the gun head adapter is reduced, and the accuracy of the volume of the residual liquid sample is improved.

As shown in fig. 3, in this embodiment, the connection plate 50 is provided with a second sliding rail 51 extending along a vertical direction, the first pipettor 30 is provided with a sliding block 34 slidably connected with the second sliding rail 51, the pipetting device further includes a second motor 70 disposed on the connection plate 50, the second motor 70 includes a screw 71, the screw 71 is disposed in the sliding block 34 in a penetrating manner, and a threaded hole disposed in the sliding block 34 in cooperation with the screw 71 is disposed. In the above structure, the rotation of the screw 71 of the second motor 70 can drive the slide 34 to move in the vertical direction, and the first pipettor 30 is connected with the slide 34, so that the second motor 70 can drive the first pipettor 30 to move in the vertical direction when rotating.

It should be noted that, the connecting plate 50 is further provided with an optical coupler, the first pipette 30 is provided with an optical coupler baffle matched with the optical coupler, and the optical coupler can provide a reference position for the first pipette 30.

It should be further noted that the pipetting device further includes a first wire arranging frame disposed above the first beam 10, where the first wire arranging frame is used to stack the connection cables of the plurality of first pipettes 30, so that the cables do not interfere with each other when the first pipettes 30 move. Accordingly, the second beam 20 is provided with a second wire arranging frame for stacking the connection cables of the plurality of second pipettes 40, so that the cables do not interfere with each other when the second pipettes 40 move.

As shown in fig. 2, in the present embodiment, the pipetting device further includes: a frame 80, a first boom 90, and a second boom 100. Wherein the first beam 10 and the second beam 20 are arranged on the frame 80; the first cantilever 90 and the second cantilever 100 are disposed on the frame 80, the first cantilever 90 is provided with first position sensors corresponding to the plurality of first pipettes 30 one by one, and the second cantilever 100 is provided with second position sensors corresponding to the second pipettes 40. In the above structure, the first position sensor is a first optocoupler, and the plurality of first optocouplers are disposed in one-to-one correspondence with the plurality of first pipettes 30, where the first optocoupler can provide a reference position for the first pipettes 30. Correspondingly, the second position sensor is a second optical coupler, the plurality of second optical couplers are arranged in one-to-one correspondence with the plurality of second pipettors 40, and the second optical coupler can provide a reference position for the second pipettors 40.

As shown in fig. 1, in the present embodiment, the pipetting device further includes a gripping mechanical arm 110 slidably disposed on a side wall of the first beam 10 away from the first pipettor 30, and the gripping mechanical arm 110 includes a rotating jaw. In the above-described structure, the grasping arm 110 can grasp the container or the like prepared by the sample by rotating the jaw grip, and can be engaged with the first pipettor and the second pipettor on the pipetting device by rotating the jaw rotation angle.

The present application also provides a sample preparation device comprising: and the pipetting device is the pipetting device. In the above structure, the pipetting device has the advantages of convenient operation, high pipetting accuracy and the like, so the sample preparation device with the pipetting device also has the advantages.

In the description of the present invention, it should be understood that the azimuth or positional relationships indicated by the azimuth terms such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal", and "top, bottom", etc., are generally based on the azimuth or positional relationships shown in the drawings, merely to facilitate description of the present invention and simplify the description, and these azimuth terms do not indicate and imply that the apparatus or elements referred to must have a specific azimuth or be constructed and operated in a specific azimuth, and thus should not be construed as limiting the scope of protection of the present invention; the orientation word "inner and outer" refers to inner and outer relative to the contour of the respective component itself.

Spatially relative terms, such as "above … …," "above … …," "upper surface at … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial location relative to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the exemplary term "above … …" may include both orientations of "above … …" and "below … …". The device may also be positioned in other different ways (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

In addition, the terms "first", "second", etc. are used to define the components, and are only for convenience of distinguishing the corresponding components, and the terms have no special meaning unless otherwise stated, and therefore should not be construed as limiting the scope of the present invention.

The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A pipetting device comprising:

the device comprises a first cross beam (10) and a second cross beam (20), wherein the first cross beam (10) and the second cross beam (20) are oppositely arranged, and an installation space (1) is arranged between the first cross beam (10) and the second cross beam (20);

the first pipetting structure and the second pipetting structure are both arranged in the installation space (1), the first pipetting structure comprises at least one first pipetting device (30) which is movably arranged on the first cross beam (10) along the horizontal direction, the second pipetting structure comprises at least one second pipetting device (40) which is movably arranged on the second cross beam (20) along the horizontal direction, gun head adapters are arranged on the first pipetting device (30) and the second pipetting device (40), and gun head adapters of the first pipetting device (30) and gun head adapters of the second pipetting device (40) are arranged in a row.

2. Pipetting device according to claim 1, wherein at least one first pipetting device (30) is arranged at a distance from at least one second pipetting device (40).

3. Pipetting device according to claim 1, wherein the first and second pipettes (30, 40) each comprise:

a sleeve assembly (31) comprising a sleeve and a plunger disposed within the sleeve, the sleeve having a pipetting chamber therein, the plunger being movably disposed within the pipetting chamber;

the gun head adapter (32) is used for connecting a gun head, the gun head adapter (32) is connected to the sleeve assembly (31), a first channel is formed in the gun head adapter (32), and the first channel is communicated with the pipetting cavity;

the connecting crank arm (33) is arranged between the gun head adapter (32) and the sleeve assembly (31), a second channel is arranged in the connecting crank arm (33), and the second channel is communicated with the first channel and the pipetting cavity.

4. A pipetting device according to any one of claims 1 to 3, wherein the first cross beam (10) is provided with a first slide rail, the pipetting device further comprising:

the mounting seat is arranged on the first cross beam (10) in a sliding manner, and the first pipetting structure is arranged on the mounting seat;

and the driving structure (60) is arranged between the first cross beam (10) and the mounting seat so as to drive the mounting seat to move on the first cross beam (10).

5. The pipetting device of claim 4 wherein the pipetting device comprises a pipetting device,

the mounting seat comprises a plurality of connecting plates (50) which are connected with the first pipettes (30) in a one-to-one correspondence manner, and each connecting plate (50) is slidably arranged on the first sliding rail;

the driving structure (60) comprises a toothed belt (61) and a plurality of first motors (62), each first motor (62) is connected with one connecting plate (50), the toothed belt (61) is arranged on the first cross beam (10), each first motor (62) is fixedly provided with a gear sleeve (63) in a rotating shaft, and each gear sleeve (63) on each first motor (62) is meshed with the toothed belt (61).

6. The pipetting device of claim 5 wherein the pipetting device comprises a pipetting device,

the rack belt (61) comprises a first belt body (611) and a second belt body (612) which are arranged at intervals along the height direction of the first cross beam (10), and the gear sleeves (63) of two first motors (62) which are arranged arbitrarily adjacently are respectively meshed with the first belt body (611) and the second belt body (612).

7. The pipetting device as recited in claim 6 wherein,

the two ends of the first belt body (611) are respectively fixed at the two opposite ends of the first cross beam (10), two tensioning wheels (64) which are parallel to the rotating shaft are further arranged on each first motor (62), the axis of the rotating shaft of the first motor (62) and the axes of the two tensioning wheels (64) form a triangular structure, the first belt body (611) is wound on the gear sleeve (63) and the two tensioning wheels (64), the gear sleeve (63) is meshed with toothed surfaces of the first belt body (611), and the two tensioning wheels (64) are matched with non-toothed surfaces of the first belt body (611).

8. Pipetting device according to claim 5, wherein the first pipetting device (30) is arranged on the connection plate (50) movably in a vertical direction.

9. The pipetting device of claim 5 wherein the pipetting device comprises a pipetting device,

be provided with on connecting plate (50) along second slide rail (51) of vertical direction extension, be provided with on first pipettor (30) with slider (34) of second slide rail (51) sliding connection, pipetting device still including set up in second motor (70) on connecting plate (50), second motor (70) include lead screw (71), lead screw (71) wear to locate in slider (34), be provided with in slider (34) with screw hole that lead screw (71) cooperation set up.

10. The pipetting device of claim 1, further comprising:

a frame (80), wherein the first beam (10) and the second beam (20) are arranged on the frame (80);

the first cantilever (90) and the second cantilever (100) are arranged on the frame (80), first position sensors which are arranged in one-to-one correspondence with the plurality of first pipettes (30) are arranged on the first cantilever (90), and second position sensors which are arranged in correspondence with the second pipettes (40) are arranged on the second cantilever (100).

11. The pipetting device of claim 1, further comprising:

the grabbing mechanical arm (110) is slidably arranged on the side wall, far away from the first pipettor (30), of the first cross beam (10), and the grabbing mechanical arm (110) comprises a rotating clamping jaw.

12. A sample preparation device, comprising:

a pipetting device according to any one of claims 1 to 11.