CN116059479A - Electrospray atomization system - Google Patents

Abstract

The invention relates to an electrospray atomization system, which comprises a liquid storage bin for storing atomized liquid; at least one micro-channel and at least one spray head which are sequentially connected with the liquid storage bin; The high-voltage electrode electrically connected to the atomized liquid is used to apply high-voltage electricity to the atomized liquid; and a syringe pump, the syringe pump includes an air pressure chamber communicated with the liquid storage chamber, and the syringe pump Pressure can be applied to the liquid storage chamber through the air pressure chamber, so as to press the atomized liquid in the liquid storage chamber to be sprayed from the at least one spray head through the at least one micro-channel. The droplets sprayed from the nozzle can burst under the action of electrostatic repulsion to form smaller droplets, so as to realize the atomization of the atomized liquid. The particle size of the aerosol formed after atomization is at the nanometer level, and the atomization The process is a low-temperature process and has no effect on biologically active ingredients. In addition, the flow rate and particle size of the aerosol after atomization are controllable.

Description

Electrospray atomization system

technical field

The invention relates to the field of atomization, and more specifically relates to an electrospray atomization system.

Background technique

At present, the method of making drugs into aerosol particles and then delivering them to the human respiratory tract has attracted more and more attention. This nebulized drug delivery method has the following advantages: accurate drug delivery to the respiratory tract or lungs; faster drug absorption in the lungs. Based on the characteristics of this drug delivery method, many requirements are put forward for the way of drug atomization, for example: 1. The particle size of the aerosol after atomization is controllable. According to the different requirements of the deposition position, the particle size of the generated aerosol needs to be adjusted. 2. During the atomization process, it is necessary to ensure that the active ingredients are not affected, and at the same time, no new harmful ingredients are produced to endanger human health.

At present, the existing atomization methods include compressed air atomization, ultrasonic atomization, etc., and the particle size produced is relatively large, and the proportion of deposition in the respiratory tract is high and the proportion of entering the lungs is low, so it can only be applied to the upper respiratory tract. Drug nebulization. Another atomization method is heating atomization, that is, the liquid is turned into vapor by heating, and then an aerosol is formed under the action of cold air. The problem with this atomization method is that the heating process may change the chemical properties of the drug , it is also possible to generate additional harmful substances due to heating.

Contents of the invention

The technical problem to be solved by the present invention is to provide an electrospray atomization system based on electrospray technology in view of the above defects of the prior art.

The technical solution adopted by the present invention to solve its technical problems is: construct a kind of electrospray atomization system, comprising:

Liquid storage bin, used to store atomized liquid;

At least one micro-channel and at least one spray head that are sequentially connected to the liquid storage bin;

a high-voltage electrode electrically connected to the atomized liquid in the liquid storage bin, for applying high-voltage electricity to the atomized liquid; and

A syringe pump, the syringe pump includes an air pressure chamber communicated with the liquid storage chamber, and the syringe pump can apply pressure to the liquid storage chamber through the air pressure chamber to compress the liquid storage chamber in the The atomized liquid is sprayed from the at least one spray head through the at least one micro-channel.

In some embodiments, the high voltage is 3kV˜5kV.

In some embodiments, the high-voltage electrode is disposed on the inner surface of the liquid storage bin and directly contacts and connects with the atomized liquid in the liquid storage bin.

In some embodiments, the electrospray atomization system further includes a control module, a high-voltage module and a power supply electrically connected to the control module, and the high-voltage electrode is electrically connected to the high-voltage module.

In some embodiments, the injection pump includes a motor, a piston rod, a piston, and a piston cylinder, and the air pressure cavity is formed in the piston cylinder; the motor is electrically connected to the control module, and the motor passes through the The piston rod drives the piston to move in the piston cylinder to compress the volume of the air pressure cavity, thereby applying pressure to the liquid storage chamber.

In some embodiments, the electrospray atomization system further includes an air pressure sensor communicated with the air pressure chamber to detect the gas pressure in the air pressure chamber.

In some embodiments, the air pressure sensor is electrically connected to the control module; the control module can receive a detection signal from the air pressure sensor, and control the rotation speed of the motor according to the detection signal.

In some embodiments, the electrospray atomization system further includes a ground electrode and a pull electrode electrically connected to the high-voltage module; The aerosol sprayed by the at least one spray head exerts high-pressure traction.

In some embodiments, the electrospray atomization system further includes a monitoring module, configured to monitor the current between the high-voltage electrodes, and report an error and give an early warning when the current is unstable.

In some embodiments, the syringe pump is also used to retreat after the atomization is completed, so that a negative pressure is formed in the air pressure chamber, and the liquid in the at least one spray head is sucked back to the liquid storage chamber.

In some embodiments, the negative pressure ranges from -0.5 to 10 kPa.

In some embodiments, the electrospray atomization system further includes at least one one-way valve disposed in the at least one microchannel to maintain a continuous negative pressure in the liquid storage chamber.

In some embodiments, the electrospray atomization system further includes a refrigeration module disposed in the liquid storage bin for cooling down and controlling the temperature of the atomized liquid in the liquid storage bin.

In some embodiments, the cooling module includes a semiconductor cooling chip, and the cooling module is arranged on the outer surface of the liquid storage bin.

In some embodiments, the electrospray atomization system further includes a stirrer disposed in the liquid storage bin for stirring the atomized liquid in the liquid storage bin.

In some embodiments, the agitator includes a magnetic mixing rotor.

In some embodiments, the conductivity range of the atomized liquid is 20-20000 μΩ ⁻¹ /cm.

In some embodiments, there are multiple shower heads, and multiple shower heads are arranged in an array.

In some embodiments, the electrospray atomization system further includes a casing for accommodating the liquid storage bin, the high-voltage electrode, and the syringe pump, and a suction nozzle provided on the casing for aerosol output .

Implementing the present invention has at least the following beneficial effects: the droplets sprayed from the nozzle can burst under the action of electrostatic repulsion to form smaller droplets, thereby realizing the atomization of the atomized liquid, and the aerosol particles formed after atomization The diameter is at the nanometer level, and the atomization process is a low-temperature process, which has no effect on biologically active components; in addition, the atomization system can also adjust the gas pressure in the air chamber, the number of microchannels, and the flow cutoff of the microchannels. Area and other parameters to control the atomization flow rate of the atomized liquid, by adjusting the conductivity of the atomized liquid, the aperture of the nozzle, the atomization voltage, the liquid supply speed and other parameters to control the particle size of the aerosol after atomization, so that after atomization The aerosol flow is controllable and the particle size is controllable.

Description of drawings

The present invention will be further described below in conjunction with accompanying drawing and embodiment, in the accompanying drawing:

Fig. 1 is a schematic structural view of an electrospray atomization system in some embodiments of the present invention;

Fig. 2 is a schematic structural view of the control system of the electrospray atomization system in some embodiments of the present invention;

Fig. 3 is the particle size distribution diagram after the atomization of the aqueous glucose solution through the electrospray atomization system shown in Fig. 1;

Fig. 4 is a graph showing the relationship between liquid flow and pressure drop when a 20mm-length microchannel water experiment is used.

Detailed ways

In order to have a clearer understanding of the technical features, purposes and effects of the present invention, the specific implementation manners of the present invention will now be described in detail with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial" The orientation or positional relationship indicated by , "radial", "circumferential", etc. is based on the orientation or positional relationship shown in the drawings or the orientation or positional relationship that is usually placed when the product of the present invention is used, and is only for the convenience of describing the present invention. The invention and the simplified description do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and thus should not be construed as limiting the present invention.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

In the present invention, unless otherwise clearly specified and limited, terms such as "installation", "connection", "connection" and "fixation" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection , or integrated; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components or the interaction relationship between two components, unless otherwise specified limit. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.

In the present invention, unless otherwise clearly specified and limited, the first feature may be in direct contact with the first feature or the first and second feature may be in direct contact with the second feature through an intermediary. touch. Moreover, "above", "above" and "above" the first feature on the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. "Below", "beneath" and "beneath" the first feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is less horizontally than the second feature.

It should be noted that when an element is referred to as being “fixed on” or “disposed on” another element, it may be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or intervening elements may also be present. As used herein, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions are for the purpose of illustration only and are not intended to represent the only embodiments.

1-2 show an electrospray atomization system 100 in some embodiments of the present invention. The overall structure of the electrospray atomization system 100 is small, easy to carry and use, and it can be applied to the atomization of an atomizing liquid 200 . The atomized liquid 200 may include a medical solution, which generally includes a drug carrier and a drug component added to the drug carrier, and the drug carrier includes but not limited to water or ethanol and other media. The electrospray atomization system 100 may include a liquid storage tank 10 , a liquid flow path 15 , a control module 2 , a high pressure module 7 , and a syringe pump 8 . The liquid storage bin 10 is used to store the atomized liquid 200 , and the syringe pump 8 is used to apply pressure to the liquid storage bin 10 to press the atomized liquid 200 in the liquid storage bin 10 to be ejected through the liquid flow path 15 . The high-voltage module 7 is used to apply a high voltage to the atomized liquid 200 in the liquid storage tank 10, so that the charge accumulates on the droplet. When the charge on the surface of the droplet exceeds the limit that it can achieve, it will drive the droplet to generate The smaller liquid droplets formed by the blasting can realize the atomization of the atomized liquid 200 . The present invention atomizes the atomizing liquid 200 through the electrospray technology, and the atomization process is a low-temperature (usually room temperature) process, which has no effect on the bioactive components, thereby avoiding the denaturation of the bioactive components due to high temperature. In addition, since the electrospray technology achieves atomization through the electrostatic repulsion inside the liquid droplets, the particle size of the aerosol after bursting can be controlled by adjusting the conductivity of the atomized liquid 200 . Generally, the greater the conductivity of the atomized liquid 200, the smaller the particles formed after bursting, that is, the smaller the particle size of the aerosol formed after atomization. In some embodiments, the conductivity of the atomized liquid 200 ranges from 20 to 20000 μΩ ⁻¹ /cm, and within this range, a more suitable aerosol particle size can be obtained.

The syringe pump 8 may include a piston cylinder 84 , a piston 83 movably disposed in the piston cylinder 84 , a piston rod 82 connected to the piston 83 , and a motor 81 connected to the piston rod 82 . An air pressure chamber 80 is formed in the piston cylinder 84 , and the air pressure chamber 80 communicates with the liquid storage chamber 10 , and the syringe pump 8 can apply pressure to the liquid storage chamber 10 through the air pressure chamber 80 . In some embodiments, the electrode 81 can be a stepper motor, and the piston rod 82 can be a screw rod. The motor 81 is connected to the control module 2, the motor 81 can rotate under the control of the control module 2, and then the piston rod 82 drives the piston 83 to move upward in the piston cylinder 84, and the piston 83 compresses the volume of the air chamber 80 during the upward movement , so as to generate a gas pressure, which acts on the atomized liquid 200 in the liquid storage bin 10 to push the atomized liquid 200 out of the liquid flow path 15 . The liquid droplets flowing out from the liquid flow path 15 have high voltage characteristics, and after a large amount of charges are accumulated on the liquid droplets, they will burst due to electrostatic repulsion to form smaller liquid droplets, thereby completing the atomization. The amount of atomization in each atomization process is controlled by the compression volume of the air pressure chamber 80 , the larger the compression volume, the more mass of the pushed solution, which corresponds to a larger atomization amount. Therefore, the compression volume of the air pressure chamber 80 can be controlled by the motor 81, thereby controlling the quality of the liquid pushed out and realizing quantitative atomization.

The liquid flow path 15 may include at least one micro-channel 11 communicated with the liquid storage bin 10 and at least one spray head 14 communicated with the at least one micro-channel 11 , the atomized liquid 200 in the liquid storage bin 10 passes through the micro-flow Road 11 is extruded from nozzle 14 again. The microchannel 11 can be used to control the liquid flow rate of the pumped liquid. Specifically, there may be one or more micro-channels 11, and the appropriate number of micro-channels 11 and the cross-sectional area of the micro-channels 11 can be selected according to the resistance coefficient of the atomized liquid 200 moving in the micro-channels 11 to control The liquid flow rate of the pumped liquid. When the structure of the microchannel 11 is determined, the liquid flow rate of the liquid supply is determined by the gas pressure in the air pressure chamber 80 , and the liquid flow rate of the liquid supply can be controlled by controlling the gas pressure in the air pressure chamber 80 . In some embodiments, the electrospray atomization system 100 may further include an air pressure sensor 9 communicating with the air pressure chamber 80 for detecting the gas pressure in the air pressure chamber 80 . The air pressure sensor 9 can be connected with the control module 2. During the atomization process, the air pressure sensor 9 can detect the gas pressure in the air pressure chamber 80 and can feed back the detection signal to the control module 2. The control module 2 can use the detection signal to The rotation speed of the motor 81 is controlled to ensure that the gas pressure in the air pressure chamber 80 remains stable, so as to realize the control of the atomization flow rate of the atomization liquid and realize the quantitative atomization of the atomization liquid.

In some embodiments, the length of the micro-channel 11 may be 5-50 mm. The axial direction of the micro-channel 11 may be parallel to the axial direction of the nozzle 14 . Preferably, there are multiple shower heads 14, and the multiple shower heads 14 may be distributed in an array. By adjusting the aperture of the nozzle 14, the particle size of the aerosol formed after atomization can be regulated. In some embodiments, the liquid flow path 15 may also include a confluence channel 13 connected between the at least one micro-channel 11 and the plurality of nozzles 14, and the atomized liquid 200 in the liquid storage bin 10 passes through the micro-channel 11 Flow to the confluence channel 13, and then extrude through the nozzle 14.

The electrospray atomization system 100 may further include a high voltage electrode 71 and a ground electrode 73 electrically connected to the high voltage module 7 . The high-voltage electrode 71 can be arranged on the inner surface of the liquid storage bin 10, so that the high-voltage electrode 71 is in direct contact with the atomized liquid 200 in the liquid storage bin 10, so that the entire atomized liquid 200 can be charged with high voltage. During the atomization process, a high voltage (i.e. atomization voltage) is applied between the high-voltage electrode 71 and the ground electrode 73. The high voltage can be a positive high voltage and can be about 3kV to 5kV, and then the motor 81 is controlled to rotate and compress the air pressure. The chamber 80 presses the atomizing liquid 200 to squeeze out from the nozzle 14 to realize atomization. During the atomization process, millimeter-scale large droplets form nanometer-scale small droplets through electrostatic interaction. By adjusting the parameters such as the conductivity of the atomizing liquid 200, atomizing voltage, liquid supply speed, surface tension, and the aperture of the nozzle 14, the particle size of the aerosol generated after atomization can be controlled and optimized, and the generated aerosol The monodispersity of the sol is also strong. When the electrospray atomization system 100 is used to atomize the liquid medicine, the particle size of the atomized aerosol can be controlled according to the deposition position of the liquid medicine in the human body. In addition, since the drug molecule is always in the solution, its dispersion process is also accompanied by the solution, so its drug effect and concentration uniformity in the solution are not affected.

Further, the electrospray atomization system 100 may further include a pull electrode 72 electrically connected to the high voltage module 7, so that the atomized aerosol can fly out better. The pulling electrode 72 can be arranged corresponding to the nozzles of the plurality of nozzles 14, and the high voltage pulling is applied through the pulling electrode 72, while keeping the internal components grounded through the grounding electrode 73, so that the aerosol extruded from the nozzles 14 is accelerated to fly out.

In some embodiments, the electrospray atomization system 100 may further include a monitoring module 4 connected to the control module 2 . When the atomization is normal, the atomized aerosol will take away part of the charge, that is, generate a micro current (generally at the nA and μA level). When the atomization is abnormal, the current is too small or the current is unstable. Therefore, during the atomization process, the current between the high-voltage electrodes 71 can be dynamically monitored through the monitoring module 4, and an error report and early warning can be performed when the current is unstable. Usually, when the current suddenly increases, it may be due to short-circuit of internal components and discharge; when the current suddenly decreases, it may be due to insufficient liquid supply or blocked pipes, and a good atomization process has not been formed.

In addition, after a single atomization is completed, some liquid will remain in the nozzle 14, and as the solvent in the liquid volatilizes, the solute may block the nozzle. Therefore, after the atomization is completed, the control module 2 can be used to control the motor 81 to rotate in reverse, so as to drive the piston 83 to move downward and retreat, so that the volume of the air pressure chamber 80 increases, so that a negative pressure is formed in the air pressure chamber 80, and then The liquid in the spray head 14 is sucked back into the liquid storage tank 10 . In some embodiments, the negative pressure may range from -0.5 to 10 kPa. Furthermore, a one-way valve 12 can also be provided at the micro-channel 11 to prevent air from entering the liquid storage chamber 10 and maintain a continuous negative pressure in the liquid storage chamber 10 . The one-way valve 12 can be arranged in the confluence channel 13 and correspond to the micro-channels 11 one by one.

With the development of atomization technology, the atomized liquid 200 to be atomized includes various characteristics, for example: 1. Some liquid medicines can only be kept at a relatively low temperature, for example, some inhaled vaccines need to be kept at 2-8°C; 2. Part of the drug to be nebulized is insoluble in the solvent and presents a state of suspension. Therefore, preferably, the electrospray atomization system 100 may further include a refrigeration module 3 and a stirrer 16 connected to the control module 2 . The refrigeration module 3 can be used to cool and control the temperature of the atomized liquid 200 in the liquid storage bin 10 , so that the atomized liquid 200 can be stored in the liquid storage bin 10 for a short time. In some embodiments, the cooling module 3 may include a semiconductor cooling chip, which may be disposed on the outer surface of the liquid storage bin 10 . The agitator 16 may include a magnetically controlled mixing rotor arranged in the atomized liquid 200, and the magnetically controlled mixed rotor may be continuously rotated in the atomized liquid 200 by an external magnetic field to prevent the agglomeration and precipitation. Through the refrigeration module 3 and the agitator 16, the atomized liquid 200 to be atomized can contain as many kinds as possible.

In some embodiments, the electrospray atomization system 100 may further include a housing 1 , a suction nozzle 5 , a power source 6 and a control switch 17 . The housing 1 is hollow and cylindrical, and is used to accommodate the liquid storage tank 10 , the liquid flow path 15 , the control module 2 , the refrigeration module 3 , the monitoring module 4 , the power supply 6 , the high pressure module 7 , the syringe pump 8 and the air pressure sensor 9 . One side of the casing 1 is provided with a nozzle opening 18, where the suction nozzle 5 is installed, and the aerosol formed after atomization in the casing 1 flows out through the suction nozzle 5 for the user to inhale. The nozzle 5 may include a first nozzle part 51 communicating with the inside of the housing 1 and a second nozzle part 52 communicating with the first nozzle part 51 . The first suction nozzle part 51 may be in the shape of a bell mouth, and its aperture gradually decreases from the end facing the inside of the housing 1 to the end communicating with the first suction nozzle part 51, so that the aerosol can be more concentrated. The second suction nozzle part 52 can be in the shape of a straight cylinder with a small cross-sectional dimension, which is convenient for being contained in the mouth.

The power supply 6 is electrically connected to the control module 2 and can supply power to the control module 2 . The control switch 17 can be arranged on the housing 1, and is used to receive user's operation and control the operation of the control module 2, such as start and stop of the atomization work and the like. For another example, the quantitative atomization of the atomized liquid 200 can also be realized by controlling the switch 17 to set the amount of liquid input each time.

Application case: The electrospray atomization system 100 built on the basis of the structure in Figure 1 atomizes the atomization liquid 200. The atomization liquid 200 uses 10% glucose aqueous solution. Since the glucose aqueous solution is non-conductive, sodium chloride is added as the conductivity rate-regulating substance, and adjust the conductivity of the solution to be about 400μΩ ^-1 /cm. The particle size of the aerosol produced after atomization was measured by a scanning electric mobility particle size spectrometer (SMPS, TSI Company, USA), and the particle size distribution is shown in FIG. 3 . It can be seen from the particle size distribution diagram that the particle size of the aerosol particles after atomization is all below 200nm, and the peak particle size of the particles is about 40nm.

The above application cases illustrate that the electrospray atomization system 100 can realize the atomization of the atomized liquid 200, and the atomized particles can reach the level of tens of nanometers, which is more conducive to its penetration into the deep lungs and better absorption .

FIG. 4 shows the relationship between the flow rate and the pressure drop when the length of the micro-channel 11 is 20 mm. It can be seen from the figure that the liquid flow through under different driving pressure conditions (pressure drop Pa) remains stable, and as the driving pressure increases, the liquid flow continues to increase. In this way, by controlling the driving pressure such as 500Pa, the industrial flow rate can be stably controlled at 1ml/min.

It can be understood that the above technical features can be used in any combination without limitation.

Above embodiment has only expressed the preferred embodiment of the present invention, and its description is comparatively specific and detailed, but can not therefore be interpreted as the limitation of patent scope of the present invention; It should be pointed out that, for those of ordinary skill in the art, in Under the premise of not departing from the concept of the present invention, the above-mentioned technical features can be freely combined, and some deformations and improvements can also be made, which all belong to the protection scope of the present invention; therefore, all equivalent transformations made with the scope of the claims of the present invention All modifications and modifications shall fall within the scope of the claims of the present invention.

Claims (19)

1. An electrospray atomising system comprising:

a liquid storage bin (10) for storing atomized liquid (200);

at least one micro-channel (11) and at least one spray head (14) which are sequentially communicated with the liquid storage bin (10);

a high voltage electrode (71) electrically connected to the atomized liquid (200) in the liquid storage chamber (10) for applying high voltage to the atomized liquid (200); and

-a syringe pump (8), the syringe pump (8) comprising a pneumatic chamber (80) in communication with the reservoir (10), the syringe pump (8) being capable of applying pressure to the reservoir (10) via the pneumatic chamber (80) to force the atomized liquid (200) in the reservoir (10) to be ejected from the at least one ejection head (5) via the at least one micro-channel (11).

2. The electrospray atomisation system according to claim 1 wherein the high voltage power is between 3kV and 5kV.

3. Electrospray atomisation system according to claim 1, characterized in that the high voltage electrode (71) is arranged on the inner surface of the reservoir (10) and is in direct contact connection with the atomising liquid (200) in the reservoir (10).

4. Electrospray atomisation system according to claim 1, characterized in that it further comprises a control module (2) and a high voltage module (7) and a power supply (6) electrically connected to the control module (2), respectively, the high voltage electrode (71) being electrically connected to the high voltage module (7).

5. Electrospray atomisation system according to claim 4, characterized in that the injection pump (8) comprises a motor (81), a piston rod (82), a piston (83) and a piston cylinder (84), the piston cylinder (84) having the pneumatic chamber (80) formed therein; the motor (81) is electrically connected with the control module (2), and the motor (81) drives the piston (83) to move in the piston cylinder (84) through the piston rod (82) so as to compress the volume of the air pressure cavity (80), so that pressure is applied to the liquid storage bin (10).

6. Electrospray atomisation system according to claim 5 characterized in that it further comprises a gas pressure sensor (9) in communication with the gas pressure chamber (80) for detecting the gas pressure inside the gas pressure chamber (80).

7. Electrospray atomisation system according to claim 6, characterized in that the air pressure sensor (9) is electrically connected to the control module (2); the control module (2) can receive a detection signal from the air pressure sensor (9) and control the rotating speed of the motor (81) according to the detection signal.

8. Electrospray atomisation system according to claim 4 characterized in that it further comprises a ground electrode (73) and a traction electrode (72) electrically connected to the high voltage module (7), respectively; the traction electrode (72) is provided in correspondence with the ejection port of the at least one ejection head (5) and is used for applying high-voltage traction to the aerosol ejected from the at least one ejection head (5).

9. Electrospray atomisation system according to claim 1, characterized in that it further comprises a monitoring module (4) for monitoring the current between the high voltage electrodes (71) and for reporting errors and pre-warnings when the current is unstable.

10. Electrospray atomisation system according to claim 1, characterized in that the injection pump (8) is also adapted to retract after atomisation is completed, causing a negative pressure to be formed in the pneumatic chamber (80), sucking the liquid in the at least one spray head (14) back into the reservoir (10).

11. The electrospray atomisation system according to claim 10 wherein the negative pressure is in the range of-0.5 to 10kPa.

12. Electrospray atomisation system according to claim 10 characterized in that it further comprises at least one-way valve (12) provided to the at least one micro channel (11) to maintain a continuous negative pressure inside the reservoir (10).

13. Electrospray atomisation system according to claim 1, characterized in that it further comprises a refrigeration module (3) arranged in the reservoir (10) for temperature-controlled cooling of the atomising liquid (200) in the reservoir (10).

14. Electrospray atomisation system according to claim 13, characterized in that the refrigeration module (3) comprises a semiconductor refrigeration tablet, the refrigeration module (3) being arranged on the outer surface of the reservoir (10).

15. Electrospray atomisation system according to claim 1 characterized in that it further comprises a stirrer (16) arranged in the reservoir (10) for stirring the atomising liquid (200) in the reservoir (10).

16. Electrospray atomising system according to claim 15, characterized in that the stirrer (16) comprises a magnetically controlled mixing rotor.

17. Electrospray atomisation system according to any of the claims 1-16, characterized in that the electrical conductivity of the atomisation liquid (200) is in the range of 20-20000 μΩ ^-1 /cm。

18. Electrospray atomisation system according to any of the claims 1-16, characterized in that the spray heads (5) are arranged in an array of a plurality of spray heads (5).

19. Electrospray atomising system according to any of the claims 1-16, characterized in that it further comprises a housing (1) for housing the reservoir (10), the high voltage electrode (71) and the syringe pump (8) and a suction nozzle (5) provided to the housing (1) for aerosol output.

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