CN116059479A - Electrospray atomizing system - Google Patents

Abstract

The invention relates to an electrospray atomization system, which comprises a liquid storage bin for storing atomized liquid; at least one micro-channel and at least one spray head which are sequentially communicated with the liquid storage bin; the high-voltage electrode is electrically connected with the atomized liquid in the liquid storage bin and is used for applying high-voltage electricity to the atomized liquid; and the injection pump comprises an air pressure cavity communicated with the liquid storage bin, and can apply pressure to the liquid storage bin through the air pressure cavity so as to press the atomized liquid in the liquid storage bin to be sprayed out from the at least one spray head through the at least one micro-channel. The liquid drops sprayed from the spray head can burst under the action of electrostatic repulsion force to form smaller liquid drops, so that the atomization of the atomized liquid is realized, the particle size of the aerosol formed after the atomization is at the nanometer level, and the atomization process is a low-temperature process and has no influence on bioactive components. In addition, the flow rate and the particle size of the atomized aerosol are controllable.

Description

Electrospray atomizing system

Technical Field

The present invention relates to the field of atomization, and more particularly, to an electrospray atomization system.

Background

Currently, there is increasing interest in the way medicaments are formulated as aerosol particles and then delivered to the respiratory tract of the human body. The atomized administration mode has the advantages that the administration position aiming at respiratory tract or lung is accurate; the drug absorbs more rapidly in the lungs. Based on the characteristics of this mode of administration, a number of requirements are placed on the mode of drug nebulization, such as: 1. the particle size of the atomized aerosol is controllable, and the particle size of the aerosol is required to be regulated and controlled according to different requirements of deposition positions; 2. the atomization process ensures that the effective components are not affected, and new harmful components are not produced to harm the health of human bodies.

The existing atomization modes comprise compressed air atomization, ultrasonic atomization and the like, and the generated particles are large in particle size, high in proportion of being deposited on the respiratory tract and low in proportion of entering the lung, so that the method can only be applied to medicine atomization aiming at the upper respiratory tract. Another type of nebulization is heating nebulization, i.e. the liquid is changed to a vapor by heating and then an aerosol is formed by cold air, which has the problem that the chemical properties of the drug may be changed during heating and additional harmful substances may be generated due to heating.

Disclosure of Invention

The invention aims to solve the technical problem of providing an electrospray atomization system based on an electrospray technology aiming at the defects in the prior art.

The technical scheme adopted for solving the technical problems is as follows: an electrospray atomizing system is constructed, comprising:

the liquid storage bin is used for storing atomized liquid;

at least one micro-channel and at least one spray head which are sequentially communicated with the liquid storage bin;

the high-voltage electrode is electrically connected with the atomized liquid in the liquid storage bin and is used for applying high-voltage electricity to the atomized liquid; and

the injection pump comprises an air pressure cavity communicated with the liquid storage bin, and the injection pump can apply pressure to the liquid storage bin through the air pressure cavity so as to press the atomized liquid in the liquid storage bin to be sprayed out from the at least one spray head through the at least one micro-channel.

In some embodiments, the high voltage power is 3kV to 5kV.

In some embodiments, the high voltage electrode is disposed on an inner surface of the reservoir and is in direct contact with the atomized liquid within the reservoir.

In some embodiments, the electrospray atomizing system further comprises a control module, and a high voltage module and a power supply electrically connected to the control module, respectively, the high voltage electrode being electrically connected to the high voltage module.

In some embodiments, the syringe pump comprises a motor, a piston rod, a piston, and a piston cylinder having the pneumatic chamber formed therein; the motor is electrically connected with the control module, and the motor drives the piston to move in the piston cylinder through the piston rod so as to compress the volume of the air pressure cavity, so that pressure is applied to the liquid storage bin.

In some embodiments, the electrospray atomizing system further comprises a gas pressure sensor in communication with the gas pressure chamber to detect a gas pressure within the gas pressure chamber.

In some embodiments, the air pressure sensor is electrically connected to the control module; the control module can receive a detection signal from the air pressure sensor and control the rotating speed of the motor according to the detection signal.

In some embodiments, the electrospray atomization system further comprises a ground electrode and a traction electrode electrically connected to the high voltage module, respectively; the traction electrode is arranged corresponding to the ejection port of the at least one nozzle and is used for applying high-voltage traction to aerosol ejected from the at least one nozzle.

In some embodiments, the electrospray atomization system further comprises a monitoring module, which is used for monitoring the current between the high-voltage electrodes and giving errors and early warning when the current is unstable.

In some embodiments, the syringe pump is further configured to retract after atomization is completed, so that a negative pressure is formed in the air pressure chamber, and the liquid in the at least one spray head is sucked back into the liquid storage bin.

In some embodiments, the negative pressure ranges from-0.5 to 10kPa.

In some embodiments, the electrospray atomizing system further comprises at least one-way valve disposed in the at least one microchannel to maintain a continuous negative pressure within the reservoir.

In some embodiments, the electrospray atomization system further comprises a refrigeration module disposed in the liquid storage bin for cooling and temperature control of the atomized liquid in the liquid storage bin.

In some embodiments, the refrigeration module comprises a semiconductor refrigeration sheet, the refrigeration module being disposed on an outer surface of the reservoir.

In some embodiments, the electrospray atomizing system further comprises a stirrer disposed within the reservoir for stirring the atomized liquid within the reservoir.

In some embodiments, the agitator comprises a magnetically controlled mixing rotor.

In some embodiments, the atomized liquid has a conductivity in the range of 20-20000 μΩ ^-1 /cm。

In some embodiments, the plurality of spray heads is provided, and the plurality of spray head arrays is provided.

In some embodiments, the electrospray atomizing system further comprises a housing for housing the reservoir, the high voltage electrode, and the syringe pump, and a mouthpiece disposed to the housing for aerosol output.

The implementation of the invention has at least the following beneficial effects: the liquid drops sprayed from the spray head can burst under the action of electrostatic repulsion force to form smaller liquid drops, so that the atomization of the atomized liquid is realized, the particle size of the aerosol formed after the atomization is at the nanometer level, and the atomization process is a low-temperature process and has no influence on bioactive components; in addition, the atomization system can also control the atomization flow of the atomized liquid by adjusting parameters such as the gas pressure in the gas pressure cavity, the number of micro-channels, the flow cross section of the micro-channels and the like, and control the particle size of the atomized aerosol by adjusting parameters such as the conductivity of the atomized liquid, the aperture of the spray head, the atomization voltage, the liquid supply speed and the like, so that the flow and the particle size of the atomized aerosol are controllable.

Drawings

The invention will be further described with reference to the accompanying drawings and examples, in which:

FIG. 1 is a schematic diagram of an electrospray atomizing system in some embodiments of the present disclosure;

FIG. 2 is a schematic diagram of a control system for an electrospray atomizing system in some embodiments of the present invention;

FIG. 3 is a graph of particle size distribution of an aqueous glucose solution after atomization via the electrospray atomization system shown in FIG. 1;

FIG. 4 is a graph of liquid flow versus pressure drop for an experiment using 20mm length microchannel water.

Detailed Description

For a clearer understanding of technical features, objects and effects of the present invention, a detailed description of embodiments of the present invention will be made with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may be embodied in many other forms than described herein and similarly modified by those skilled in the art without departing from the spirit of the invention, whereby the invention is not limited to the specific embodiments disclosed below.

In the description of the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or those conventionally placed in use of the present invention are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present invention.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present invention, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.

In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present invention, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are used herein for illustrative purposes only and are not meant to be the only embodiment.

Fig. 1-2 illustrate an electrospray atomization system 100 in some embodiments of the present invention, the overall structure of the electrospray atomization system 100 being compact, portable and easy to carry and use, and applicable to the atomization of an atomized liquid 200. The aerosolized liquid 200 can include a liquid drug that generally includes a drug carrier including, but not limited to, a medium such as water or ethanol, and a pharmaceutical ingredient added to the drug carrier. The electrospray atomization system 100 may include a reservoir 10, a liquid flow path 15, a control module 2, a high pressure module 7, and a syringe pump 8. The liquid storage bin 10 is used for containing the atomized liquid 200, and the injection pump 8 is used for applying pressure to the liquid storage bin 10 so as to press the atomized liquid 200 in the liquid storage bin 10 to be sprayed out through the liquid flow path 15. The high-voltage module 7 is used for applying high voltage to the atomized liquid 200 in the liquid storage bin 10 to enable charges to be accumulated on the liquid drops, and when the charges on the surfaces of the liquid drops exceed the limit reached by the liquid drops, the liquid drops are driven to be exploded to form smaller liquid drops, so that the atomized liquid 200 is atomized. The invention atomizes the atomized liquid 200 by the electrospray technology, and the atomization process is a low-temperature (usually normal temperature) process, which has no influence on the bioactive components, thereby avoiding the denaturation of the bioactive components caused by high temperature. In addition, since the electrospray technology is to realize atomization by electrostatic repulsive force inside droplets, the particle size of the aerosol after burst can be controlled by adjusting the conductivity of the atomized liquid 200. In general, the greater the conductivity of the atomized liquid 200, the smaller the particulate matter formed after bursting, i.e., the smaller the aerosol particle size formed after atomization. In some embodiments, the atomized liquid 200 has a conductivity in the range of 20 to 20000 μΩ ^-1 Within this range, a preferable aerosol particle size can be obtained.

The syringe pump 8 may include a piston cylinder 84, a piston 83 movably disposed in the piston cylinder 84, a piston rod 82 connected to the piston 83, and a motor 81 connected to the piston rod 82. The piston cylinder 84 has a pneumatic chamber 80 formed therein, the pneumatic chamber 80 being in communication with the reservoir 10, and the syringe pump 8 being operable to apply pressure to the reservoir 10 via the pneumatic chamber 80. In some embodiments, the electrode 81 may be a stepper motor and the piston rod 82 may be a lead screw. The motor 81 is connected with the control module 2, and the motor 81 can rotate under the control of the control module 2, so that the piston 83 is driven by the piston rod 82 to move upwards in the piston cylinder 84, and the volume of the air pressure cavity 80 is compressed in the upward moving process of the piston 83, so that the air pressure is generated, and the air pressure acts on the atomized liquid 200 in the liquid storage bin 10 to push the atomized liquid 200 out of the liquid flow path 15. The droplets flowing out of the liquid flow path 15 have high-voltage characteristics, and after a large amount of charges are accumulated on the droplets, they burst due to electrostatic repulsive force to form smaller droplets, thereby completing atomization. The amount of atomization per atomization process is controlled by the compressed volume of the pneumatic chamber 80, with greater compressed volume resulting in greater mass of the pushed solution, and correspondingly greater amount of atomization. Therefore, the motor 81 can control the compression volume of the air pressure cavity 80, thereby controlling the pushing-out quality of the liquid and realizing quantitative atomization.

The liquid flow path 15 may include at least one micro flow channel 11 in communication with the liquid storage bin 10 and at least one spray head 14 in communication with the at least one micro flow channel 11, and the atomized liquid 200 in the liquid storage bin 10 is extruded from the spray head 14 after passing through the micro flow channel 11. The micro flow channel 11 can be used to control the liquid flow rate of the pumped liquid. Specifically, the number of the micro flow channels 11 may be one or more, and the flow rate of the pumped liquid may be controlled by selecting a suitable number of micro flow channels 11 and the flow cross-sectional area of the micro flow channels 11 according to the resistance coefficient of the movement of the atomized liquid 200 in the micro flow channels 11. When the structure of the micro-channel 11 is determined, the liquid flow rate of the liquid supply is determined by the gas pressure in the gas pressure chamber 80, and the liquid flow rate of the liquid supply can be controlled by controlling the gas pressure in the gas pressure chamber 80. In some embodiments, the electrospray atomization system 100 may further include a gas pressure sensor 9 in communication with the gas pressure chamber 80 for detecting the gas pressure within the gas pressure chamber 80. The air pressure sensor 9 can be connected with the control module 2, in the atomization process, the air pressure in the air pressure cavity 80 is detected through the air pressure sensor 9, the detection signal can be fed back to the control module 2, the control module 2 can control the rotating speed of the motor 81 according to the detection signal, so that the air pressure in the air pressure cavity 80 is kept stable, the atomization flow of the atomized liquid is controlled, and the quantitative atomization of the atomized liquid is realized.

In some embodiments, the length of the micro flow channel 11 may be 5 to 50mm. The axis direction of the micro flow channel 11 may be parallel to the axis direction of the head 14. Preferably, there are a plurality of spray heads 14, and a plurality of spray heads 14 may be distributed in an array. The particle size of the aerosol formed after atomization can be regulated and controlled by adjusting the aperture of the spray head 14. In some embodiments, the liquid flow path 15 may further include a confluence channel 13 connected between the at least one micro flow channel 11 and the plurality of spray heads 14, and the atomized liquid 200 in the liquid storage 10 flows to the confluence channel 13 through the micro flow channel 11 and is then extruded through the spray heads 14.

The electrospray atomizing system 100 may further include a high voltage electrode 71 and a ground electrode 73 electrically connected to the high voltage module 7, respectively. The high-voltage electrode 71 may be disposed on the inner surface of the liquid storage bin 10, so that the high-voltage electrode 71 is directly contacted with the atomized liquid 200 in the liquid storage bin 10, and thus the entire atomized liquid 200 may have high-voltage. During atomization, a high voltage (i.e., an atomization voltage) is applied between the high voltage electrode 71 and the ground electrode 73, which may be a positive high voltage and may be about 3kV to 5kV, and then the motor 81 is controlled to rotate, compressing the air pressure chamber 80 to force the atomized liquid 200 to be extruded from the spray head 14, thereby achieving atomization. During atomization, large droplets of the millimeter scale form small droplets of the nanometer scale by electrostatic action. By adjusting and controlling parameters such as conductivity, atomization voltage, liquid supply speed, surface tension, aperture of the spray head 14 and the like of the atomized liquid 200, the particle size of the aerosol generated after atomization can be controlled and optimized, and the monodispersity of the generated aerosol is also strong. When the electrospray atomizing system 100 is used for atomizing a liquid medicine, the particle size of the atomized aerosol can be controlled according to the deposition position of the liquid medicine on a human body. In addition, since the drug molecules are always in solution, the dispersion process is accompanied by the solution, so that the drug effect and the concentration uniformity in the solution are not affected.

Further, the electrospray atomizing system 100 may further include a traction electrode 72 electrically connected to the high voltage module 7 to enable the atomized aerosol to fly out better. The traction electrode 72 may be provided corresponding to the ejection ports of the plurality of ejection heads 14, and high-voltage traction is applied by the traction electrode 72 while keeping the internal components grounded through the ground electrode 73 so that the aerosol extruded from the ejection heads 14 is accelerated to fly out.

In some embodiments, the electrospray atomization system 100 may further include a monitoring module 4 coupled to the control module 2. When nebulization is normal, the nebulized aerosol will take away part of the charge, i.e. generate micro-currents (typically in the nA and μa scale). When atomization is abnormal, there are cases where the current flow is small or the current is unstable. Therefore, during the atomization process, the current between the high-voltage electrodes 71 can be dynamically monitored by the monitoring module 4, and error reporting and early warning can be performed when the current is unstable. In general, when the current suddenly increases, discharge may occur due to an internal component short circuit; when the current suddenly decreases, a good atomization process is not formed, possibly due to insufficient supply or clogging of the pipe.

In addition, after a single atomization is completed, a portion of the liquid may remain in the spray head 14, and as the solvent in the liquid evaporates, the spray head may be clogged with solute. Therefore, after atomization is completed, the control module 2 can control the motor 81 to reversely rotate so as to drive the piston 83 to move downwards to retract, so that the volume of the air pressure cavity 80 is increased, negative pressure is formed in the air pressure cavity 80, and liquid in the spray head 14 is sucked back to the liquid storage bin 10. In some embodiments, the negative pressure may range from-0.5 to 10kPa. Further, a check valve 12 may be provided at the microchannel 11 to prevent air from entering the reservoir 10 and maintain a continuous negative pressure in the reservoir 10. The check valves 12 may be disposed in the confluence channels 13 and in one-to-one correspondence with the micro flow channels 11.

As atomization technology advances, the atomized liquid 200 to be atomized includes various characteristics, such as: 1. part of the liquid medicine can only be kept at a lower temperature, for example, part of the inhaled vaccine needs to be kept at 2-8 ℃; 2. part of the medicine to be atomized is insoluble in the solvent and is in the state of suspension. Accordingly, the electrospray atomizing system 100 may preferably further comprise a cooling module 3 and an agitator 16 connected to the control module 2. The refrigeration module 3 can be used for refrigerating and controlling the temperature of the atomized liquid 200 in the liquid storage bin 10, so that the atomized liquid 200 can be stored in the liquid storage bin 10 for a short period of time. In some embodiments, the refrigeration module 3 may include a semiconductor refrigeration sheet, which may be disposed on an outer surface of the sump 10. The agitator 16 may include a magnetically controlled mixing rotor disposed in the aerosolized liquid 200 that may be energized by an external magnetic field to continuously rotate in the aerosolized liquid 200, preventing agglomeration and precipitation of pharmaceutical ingredients in the suspension. By means of the refrigeration module 3 and the stirrer 16, the atomized liquid 200 to be atomized can be made to contain as many kinds as possible.

In some embodiments, the electrospray atomizing system 100 can further include a housing 1, a suction nozzle 5, a power source 6, and a control switch 17. The housing 1 has a hollow cylindrical shape and accommodates a liquid storage chamber 10, a liquid flow path 15, a control module 2, a refrigeration module 3, a monitoring module 4, a power supply 6, a high-pressure module 7, an injection pump 8, and an air pressure sensor 9. One side of the shell 1 is provided with a suction nozzle opening 18, the suction nozzle 5 is arranged at the suction nozzle opening 18, and aerosol formed after atomization in the shell 1 flows out through the suction nozzle 5 for a user to suck. The suction nozzle 5 may include a first nozzle part 51 communicating with the inside of the housing 1 and a second nozzle part 52 communicating with the first nozzle part 51. The first nozzle part 51 may have a bell mouth shape, and its aperture gradually decreases from one end toward the inside of the housing 1 to one end communicating with the first nozzle part 51, so that the aerosol may be more concentrated. The second mouthpiece portion 52 may be straight and cylindrical with a smaller cross-sectional dimension for convenient inclusion in the mouth.

The power supply 6 is electrically connected to the control module 2 and can supply power to the control module 2. A control switch 17 may be provided on the housing 1 for receiving a user operation and controlling the operation of the control module 2, such as start-stop of the atomizing operation, etc. For another example, quantitative atomization of the atomized liquid 200 may be achieved by controlling the switch 17 to set the amount of liquid input each time.

Application cases: the electrospray atomizing system 100 constructed based on the structure of fig. 1 atomizes an atomized liquid 200, and the atomized liquid 200 adopts 10% glucose aqueous solution, and sodium chloride is added as a conductivity adjusting substance because the glucose aqueous solution is non-conductive, so that the conductivity of the adjusting solution is about 400 mu omega ^-1 /cm. The particle size of the aerosol produced after atomization was measured using a scanning electron mobility particle size spectrometer (SMPS, TSI company, usa) and the particle size distribution is shown in fig. 3. From the particle size distribution, it can be seen that the aerosol after atomizationThe particle size of the particles is below 200nm, and the peak particle size of the particles is about 40 nm.

The application case description above: electrospray atomisation system 100 may achieve atomisation of an atomising liquid 200, and the particles after atomisation may reach the level of tens of nanometres, more facilitating their penetration into the deep lung for better absorption.

Fig. 4 shows a graph of flow rate versus pressure drop for a 20mm length of the microchannel 11. As can be seen from the figure, the liquid flow rate passing under different driving pressure conditions (pressure drop Pa) is kept stable, and as the driving pressure increases, the liquid flow rate also continues to increase. Thus, by controlling the driving pressure to 500Pa, the industrial flow rate can be stably controlled at 1ml/min.

It will be appreciated that the above technical features may be used in any combination without limitation.

The foregoing examples only illustrate preferred embodiments of the invention, which are described in more detail and are not to be construed as limiting the scope of the invention; it should be noted that, for a person skilled in the art, the above technical features can be freely combined, and several variations and modifications can be made without departing from the scope of the invention; therefore, all changes and modifications that come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims (19)

1. An electrospray atomising system comprising:

a liquid storage bin (10) for storing atomized liquid (200);

at least one micro-channel (11) and at least one spray head (14) which are sequentially communicated with the liquid storage bin (10);

a high voltage electrode (71) electrically connected to the atomized liquid (200) in the liquid storage chamber (10) for applying high voltage to the atomized liquid (200); and

-a syringe pump (8), the syringe pump (8) comprising a pneumatic chamber (80) in communication with the reservoir (10), the syringe pump (8) being capable of applying pressure to the reservoir (10) via the pneumatic chamber (80) to force the atomized liquid (200) in the reservoir (10) to be ejected from the at least one ejection head (5) via the at least one micro-channel (11).

2. The electrospray atomisation system according to claim 1 wherein the high voltage power is between 3kV and 5kV.

3. Electrospray atomisation system according to claim 1, characterized in that the high voltage electrode (71) is arranged on the inner surface of the reservoir (10) and is in direct contact connection with the atomising liquid (200) in the reservoir (10).

4. Electrospray atomisation system according to claim 1, characterized in that it further comprises a control module (2) and a high voltage module (7) and a power supply (6) electrically connected to the control module (2), respectively, the high voltage electrode (71) being electrically connected to the high voltage module (7).

5. Electrospray atomisation system according to claim 4, characterized in that the injection pump (8) comprises a motor (81), a piston rod (82), a piston (83) and a piston cylinder (84), the piston cylinder (84) having the pneumatic chamber (80) formed therein; the motor (81) is electrically connected with the control module (2), and the motor (81) drives the piston (83) to move in the piston cylinder (84) through the piston rod (82) so as to compress the volume of the air pressure cavity (80), so that pressure is applied to the liquid storage bin (10).

6. Electrospray atomisation system according to claim 5 characterized in that it further comprises a gas pressure sensor (9) in communication with the gas pressure chamber (80) for detecting the gas pressure inside the gas pressure chamber (80).

7. Electrospray atomisation system according to claim 6, characterized in that the air pressure sensor (9) is electrically connected to the control module (2); the control module (2) can receive a detection signal from the air pressure sensor (9) and control the rotating speed of the motor (81) according to the detection signal.

8. Electrospray atomisation system according to claim 4 characterized in that it further comprises a ground electrode (73) and a traction electrode (72) electrically connected to the high voltage module (7), respectively; the traction electrode (72) is provided in correspondence with the ejection port of the at least one ejection head (5) and is used for applying high-voltage traction to the aerosol ejected from the at least one ejection head (5).

9. Electrospray atomisation system according to claim 1, characterized in that it further comprises a monitoring module (4) for monitoring the current between the high voltage electrodes (71) and for reporting errors and pre-warnings when the current is unstable.

10. Electrospray atomisation system according to claim 1, characterized in that the injection pump (8) is also adapted to retract after atomisation is completed, causing a negative pressure to be formed in the pneumatic chamber (80), sucking the liquid in the at least one spray head (14) back into the reservoir (10).

11. The electrospray atomisation system according to claim 10 wherein the negative pressure is in the range of-0.5 to 10kPa.

12. Electrospray atomisation system according to claim 10 characterized in that it further comprises at least one-way valve (12) provided to the at least one micro channel (11) to maintain a continuous negative pressure inside the reservoir (10).

13. Electrospray atomisation system according to claim 1, characterized in that it further comprises a refrigeration module (3) arranged in the reservoir (10) for temperature-controlled cooling of the atomising liquid (200) in the reservoir (10).

14. Electrospray atomisation system according to claim 13, characterized in that the refrigeration module (3) comprises a semiconductor refrigeration tablet, the refrigeration module (3) being arranged on the outer surface of the reservoir (10).

15. Electrospray atomisation system according to claim 1 characterized in that it further comprises a stirrer (16) arranged in the reservoir (10) for stirring the atomising liquid (200) in the reservoir (10).

16. Electrospray atomising system according to claim 15, characterized in that the stirrer (16) comprises a magnetically controlled mixing rotor.

17. Electrospray atomisation system according to any of the claims 1-16, characterized in that the electrical conductivity of the atomisation liquid (200) is in the range of 20-20000 μΩ ^-1 /cm。

18. Electrospray atomisation system according to any of the claims 1-16, characterized in that the spray heads (5) are arranged in an array of a plurality of spray heads (5).

19. Electrospray atomising system according to any of the claims 1-16, characterized in that it further comprises a housing (1) for housing the reservoir (10), the high voltage electrode (71) and the syringe pump (8) and a suction nozzle (5) provided to the housing (1) for aerosol output.

Images