CN116059479A - Electrospray atomization system - Google Patents

Electrospray atomization system Download PDF

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CN116059479A
CN116059479A CN202111289653.2A CN202111289653A CN116059479A CN 116059479 A CN116059479 A CN 116059479A CN 202111289653 A CN202111289653 A CN 202111289653A CN 116059479 A CN116059479 A CN 116059479A
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electrospray
liquid
atomization
reservoir
atomisation
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薛墨
赵月阳
王开元
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Shenzhen Smoore Technology Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001Particle size control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical

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Abstract

本发明涉及一种电喷雾雾化系统,包括储液仓,用于存储雾化液;依次与所述储液仓相连通的至少一个微流道和至少一个喷头;与所述储液仓内的所述雾化液电连接的高压电极,用于对所述雾化液施加高压电;以及注射泵,所述注射泵包括与所述储液仓相连通的气压腔,所述注射泵能够经由所述气压腔对所述储液仓施加压力,以压迫所述储液仓内的所述雾化液经由所述至少一个微流道从所述至少一个喷头喷出。从喷头喷出的液滴能够在静电斥力的作用下爆裂而形成更小的液滴,从而实现对雾化液的雾化,雾化后形成的气溶胶粒径在纳米级别,且该雾化过程为低温过程,对生物活性成分无影响。此外,雾化后的气溶胶流量可控、粒径可控。

Figure 202111289653

The invention relates to an electrospray atomization system, which comprises a liquid storage bin for storing atomized liquid; at least one micro-channel and at least one spray head which are sequentially connected with the liquid storage bin; The high-voltage electrode electrically connected to the atomized liquid is used to apply high-voltage electricity to the atomized liquid; and a syringe pump, the syringe pump includes an air pressure chamber communicated with the liquid storage chamber, and the syringe pump Pressure can be applied to the liquid storage chamber through the air pressure chamber, so as to press the atomized liquid in the liquid storage chamber to be sprayed from the at least one spray head through the at least one micro-channel. The droplets sprayed from the nozzle can burst under the action of electrostatic repulsion to form smaller droplets, so as to realize the atomization of the atomized liquid. The particle size of the aerosol formed after atomization is at the nanometer level, and the atomization The process is a low-temperature process and has no effect on biologically active ingredients. In addition, the flow rate and particle size of the aerosol after atomization are controllable.

Figure 202111289653

Description

电喷雾雾化系统Electrospray atomization system

技术领域technical field

本发明涉及雾化领域,更具体地说,涉及一种电喷雾雾化系统。The invention relates to the field of atomization, and more specifically relates to an electrospray atomization system.

背景技术Background technique

目前,将药物制成气溶胶颗粒,之后输送到人体呼吸道的给药方式越来越受到关注。这种雾化给药的方式具有如下优点:针对呼吸道或肺部的给药位置精准;药物在肺部吸收的速度更快。基于这种给药方式的特点,对于药物雾化的方式提出了许多要求,例如:1、雾化后的气溶胶粒径可控,针对沉积位置的不同需求,需要对产生气溶胶的粒径进行调控;2、雾化过程要保证有效成分不受影响,同时不产生新的有害成分危害人体健康。At present, the method of making drugs into aerosol particles and then delivering them to the human respiratory tract has attracted more and more attention. This nebulized drug delivery method has the following advantages: accurate drug delivery to the respiratory tract or lungs; faster drug absorption in the lungs. Based on the characteristics of this drug delivery method, many requirements are put forward for the way of drug atomization, for example: 1. The particle size of the aerosol after atomization is controllable. According to the different requirements of the deposition position, the particle size of the generated aerosol needs to be adjusted. 2. During the atomization process, it is necessary to ensure that the active ingredients are not affected, and at the same time, no new harmful ingredients are produced to endanger human health.

目前已有的雾化方式包括压缩空气雾化、超声波雾化等方式,产生的颗粒物粒径较大,沉积在呼吸道的比例高而进入肺部的比例低,所以只能应用于针对上呼吸道的药物雾化。另外一种雾化方式是加热雾化,即通过加热使液体变为蒸汽,之后在冷空气作用下形成气溶胶,这种雾化方式存在的问题是加热过程有可能使药物的化学特性产生变化,也有可能由于加热而产生额外的有害物质。At present, the existing atomization methods include compressed air atomization, ultrasonic atomization, etc., and the particle size produced is relatively large, and the proportion of deposition in the respiratory tract is high and the proportion of entering the lungs is low, so it can only be applied to the upper respiratory tract. Drug nebulization. Another atomization method is heating atomization, that is, the liquid is turned into vapor by heating, and then an aerosol is formed under the action of cold air. The problem with this atomization method is that the heating process may change the chemical properties of the drug , it is also possible to generate additional harmful substances due to heating.

发明内容Contents of the invention

本发明要解决的技术问题在于,针对现有技术的上述缺陷,提供一种基于电喷雾技术的电喷雾雾化系统。The technical problem to be solved by the present invention is to provide an electrospray atomization system based on electrospray technology in view of the above defects of the prior art.

本发明解决其技术问题所采用的技术方案是:构造一种电喷雾雾化系统,包括:The technical solution adopted by the present invention to solve its technical problems is: construct a kind of electrospray atomization system, comprising:

储液仓,用于存储雾化液;Liquid storage bin, used to store atomized liquid;

依次与所述储液仓相连通的至少一个微流道和至少一个喷头;At least one micro-channel and at least one spray head that are sequentially connected to the liquid storage bin;

与所述储液仓内的所述雾化液电连接的高压电极,用于对所述雾化液施加高压电;以及a high-voltage electrode electrically connected to the atomized liquid in the liquid storage bin, for applying high-voltage electricity to the atomized liquid; and

注射泵,所述注射泵包括与所述储液仓相连通的气压腔,所述注射泵能够经由所述气压腔对所述储液仓施加压力,以压迫所述储液仓内的所述雾化液经由所述至少一个微流道从所述至少一个喷头喷出。A syringe pump, the syringe pump includes an air pressure chamber communicated with the liquid storage chamber, and the syringe pump can apply pressure to the liquid storage chamber through the air pressure chamber to compress the liquid storage chamber in the The atomized liquid is sprayed from the at least one spray head through the at least one micro-channel.

在一些实施例中,所述高压电为3kV~5kV。In some embodiments, the high voltage is 3kV˜5kV.

在一些实施例中,所述高压电极设置于所述储液仓的内表面并与所述储液仓内的所述雾化液直接接触连接。In some embodiments, the high-voltage electrode is disposed on the inner surface of the liquid storage bin and directly contacts and connects with the atomized liquid in the liquid storage bin.

在一些实施例中,所述电喷雾雾化系统还包括控制模块以及分别与所述控制模块电连接的高压模块和电源,所述高压电极与所述高压模块电连接。In some embodiments, the electrospray atomization system further includes a control module, a high-voltage module and a power supply electrically connected to the control module, and the high-voltage electrode is electrically connected to the high-voltage module.

在一些实施例中,所述注射泵包括电机、活塞杆、活塞以及活塞缸,所述活塞缸内形成有所述气压腔;所述电机与所述控制模块电连接,所述电机通过所述活塞杆带动所述活塞在所述活塞缸中运动以压缩所述气压腔的体积,从而对所述储液仓施加压力。In some embodiments, the injection pump includes a motor, a piston rod, a piston, and a piston cylinder, and the air pressure cavity is formed in the piston cylinder; the motor is electrically connected to the control module, and the motor passes through the The piston rod drives the piston to move in the piston cylinder to compress the volume of the air pressure cavity, thereby applying pressure to the liquid storage chamber.

在一些实施例中,所述电喷雾雾化系统还包括与所述气压腔相连通的气压传感器,以检测所述气压腔内的气体压强。In some embodiments, the electrospray atomization system further includes an air pressure sensor communicated with the air pressure chamber to detect the gas pressure in the air pressure chamber.

在一些实施例中,所述气压传感器与所述控制模块电连接;所述控制模块能够接收来自所述气压传感器的检测信号,并根据所述检测信号控制所述电机的转速。In some embodiments, the air pressure sensor is electrically connected to the control module; the control module can receive a detection signal from the air pressure sensor, and control the rotation speed of the motor according to the detection signal.

在一些实施例中,所述电喷雾雾化系统还包括分别与所述高压模块电连接的接地电极和牵引电极;所述牵引电极与所述至少一个喷头的喷出口对应设置,用于对从所述至少一个喷头喷出的气溶胶施加高压牵引。In some embodiments, the electrospray atomization system further includes a ground electrode and a pull electrode electrically connected to the high-voltage module; The aerosol sprayed by the at least one spray head exerts high-pressure traction.

在一些实施例中,所述电喷雾雾化系统还包括监控模块,用于对所述高压电极间的电流进行监控,并在所述电流不稳定时进行报错和预警。In some embodiments, the electrospray atomization system further includes a monitoring module, configured to monitor the current between the high-voltage electrodes, and report an error and give an early warning when the current is unstable.

在一些实施例中,所述注射泵还用于在雾化完成后进行回退,使所述气压腔内形成负压,将所述至少一个喷头中的液体吸回到所述储液仓。In some embodiments, the syringe pump is also used to retreat after the atomization is completed, so that a negative pressure is formed in the air pressure chamber, and the liquid in the at least one spray head is sucked back to the liquid storage chamber.

在一些实施例中,所述负压的范围为-0.5~10kPa。In some embodiments, the negative pressure ranges from -0.5 to 10 kPa.

在一些实施例中,所述电喷雾雾化系统还包括设置于所述至少一个微流道的至少一个单向阀,以保持所述储液仓内的持续负压。In some embodiments, the electrospray atomization system further includes at least one one-way valve disposed in the at least one microchannel to maintain a continuous negative pressure in the liquid storage chamber.

在一些实施例中,所述电喷雾雾化系统还包括设置于所述储液仓用于对所述储液仓内的所述雾化液进行降温和温度控制的制冷模块。In some embodiments, the electrospray atomization system further includes a refrigeration module disposed in the liquid storage bin for cooling down and controlling the temperature of the atomized liquid in the liquid storage bin.

在一些实施例中,所述制冷模块包括半导体制冷片,所述制冷模块设置于所述储液仓的外表面。In some embodiments, the cooling module includes a semiconductor cooling chip, and the cooling module is arranged on the outer surface of the liquid storage bin.

在一些实施例中,所述电喷雾雾化系统还包括设置于所述储液仓内用于对所述储液仓内的所述雾化液进行搅拌的搅拌器。In some embodiments, the electrospray atomization system further includes a stirrer disposed in the liquid storage bin for stirring the atomized liquid in the liquid storage bin.

在一些实施例中,所述搅拌器包括磁控混合转子。In some embodiments, the agitator includes a magnetic mixing rotor.

在一些实施例中,所述雾化液的电导率范围为20-20000μΩ-1/cm。In some embodiments, the conductivity range of the atomized liquid is 20-20000 μΩ −1 /cm.

在一些实施例中,所述喷头有多个,多个所述喷头阵列设置。In some embodiments, there are multiple shower heads, and multiple shower heads are arranged in an array.

在一些实施例中,所述电喷雾雾化系统还包括用于收容所述储液仓、所述高压电极和所述注射泵的外壳以及设置于所述外壳用于供气溶胶输出的吸嘴。In some embodiments, the electrospray atomization system further includes a casing for accommodating the liquid storage bin, the high-voltage electrode, and the syringe pump, and a suction nozzle provided on the casing for aerosol output .

实施本发明至少具有以下有益效果:从喷头喷出的液滴能够在静电斥力的作用下爆裂而形成更小的液滴,从而实现对雾化液的雾化,雾化后形成的气溶胶粒径在纳米级别,且该雾化过程为低温过程,对生物活性成分无影响;此外,该雾化系统还可通过调节气压腔内的气体压强、微流道的数量、微流道的流通截面积等参数来控制雾化液的雾化流量,通过调节雾化液的电导率、喷头的孔径、雾化电压、供液速度等参数来控制雾化后的气溶胶粒径,使得雾化后的气溶胶流量可控、粒径可控。Implementing the present invention has at least the following beneficial effects: the droplets sprayed from the nozzle can burst under the action of electrostatic repulsion to form smaller droplets, thereby realizing the atomization of the atomized liquid, and the aerosol particles formed after atomization The diameter is at the nanometer level, and the atomization process is a low-temperature process, which has no effect on biologically active components; in addition, the atomization system can also adjust the gas pressure in the air chamber, the number of microchannels, and the flow cutoff of the microchannels. Area and other parameters to control the atomization flow rate of the atomized liquid, by adjusting the conductivity of the atomized liquid, the aperture of the nozzle, the atomization voltage, the liquid supply speed and other parameters to control the particle size of the aerosol after atomization, so that after atomization The aerosol flow is controllable and the particle size is controllable.

附图说明Description of drawings

下面将结合附图及实施例对本发明作进一步说明,附图中:The present invention will be further described below in conjunction with accompanying drawing and embodiment, in the accompanying drawing:

图1是本发明一些实施例中电喷雾雾化系统的结构示意图;Fig. 1 is a schematic structural view of an electrospray atomization system in some embodiments of the present invention;

图2是本发明一些实施例中电喷雾雾化系统的控制系统的结构示意图;Fig. 2 is a schematic structural view of the control system of the electrospray atomization system in some embodiments of the present invention;

图3是葡萄糖水溶液经由图1所示的电喷雾雾化系统雾化后的粒径分布图;Fig. 3 is the particle size distribution diagram after the atomization of the aqueous glucose solution through the electrospray atomization system shown in Fig. 1;

图4是采用20mm长度微流道水实验时的液体流量与压降关系图。Fig. 4 is a graph showing the relationship between liquid flow and pressure drop when a 20mm-length microchannel water experiment is used.

具体实施方式Detailed ways

为了对本发明的技术特征、目的和效果有更加清楚的理解,现对照附图详细说明本发明的具体实施方式。在下面的描述中阐述了很多具体细节以便于充分理解本发明。但是本发明能够以很多不同于在此描述的其它方式来实施,本领域技术人员可以在不违背本发明内涵的情况下做类似改进,因此本发明不受下面公开的具体实施例的限制。In order to have a clearer understanding of the technical features, purposes and effects of the present invention, the specific implementation manners of the present invention will now be described in detail with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

在本发明的描述中,需要理解的是,术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”、“顺时针”、“逆时针”、“轴向”、“径向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系或者是本发明产品使用时惯常摆放的方位或位置关系,仅是为了便于描述本发明和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,因此不能理解为对本发明的限制。In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial" The orientation or positional relationship indicated by , "radial", "circumferential", etc. is based on the orientation or positional relationship shown in the drawings or the orientation or positional relationship that is usually placed when the product of the present invention is used, and is only for the convenience of describing the present invention. The invention and the simplified description do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and thus should not be construed as limiting the present invention.

此外,术语“第一”、“第二”仅用于描述目的,而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此,限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。在本发明的描述中,“多个”的含义是至少两个,例如两个,三个等,除非另有明确具体的限定。In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

在本发明中,除非另有明确的规定和限定,术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解,例如,可以是固定连接,也可以是可拆卸连接,或成一体;可以是机械连接,也可以是电连接;可以是直接相连,也可以通过中间媒介间接相连,可以是两个元件内部的连通或两个元件的相互作用关系,除非另有明确的限定。对于本领域的普通技术人员而言,可以根据具体情况理解上述术语在本发明中的具体含义。In the present invention, unless otherwise clearly specified and limited, terms such as "installation", "connection", "connection" and "fixation" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection , or integrated; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components or the interaction relationship between two components, unless otherwise specified limit. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.

在本发明中,除非另有明确的规定和限定,第一特征在第二特征“上”或“下”可以是第一和第二特征直接接触,或第一和第二特征通过中间媒介间接接触。而且,第一特征在第二特征“之上”、“上方”和“上面”可是第一特征在第二特征正上方或斜上方,或仅仅表示第一特征水平高度高于第二特征。第一特征在第二特征“之下”、“下方”和“下面”可以是第一特征在第二特征正下方或斜下方,或仅仅表示第一特征水平高度小于第二特征。In the present invention, unless otherwise clearly specified and limited, the first feature may be in direct contact with the first feature or the first and second feature may be in direct contact with the second feature through an intermediary. touch. Moreover, "above", "above" and "above" the first feature on the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. "Below", "beneath" and "beneath" the first feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is less horizontally than the second feature.

需要说明的是,当元件被称为“固定于”或“设置于”另一个元件,它可以直接在另一个元件上或者也可以存在居中的元件。当一个元件被认为是“连接”另一个元件,它可以是直接连接到另一个元件或者可能同时存在居中元件。本文所使用的术语“垂直的”、“水平的”、“上”、“下”、“左”、“右”以及类似的表述只是为了说明的目的,并不表示是唯一的实施方式。It should be noted that when an element is referred to as being “fixed on” or “disposed on” another element, it may be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or intervening elements may also be present. As used herein, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions are for the purpose of illustration only and are not intended to represent the only embodiments.

图1-2示出了本发明一些实施例中的电喷雾雾化系统100,该电喷雾雾化系统100的整体结构小型,便于携带和使用,其可应用于雾化液200的雾化。该雾化液200可包括药液,该药液一般包括药物载体以及添加于药物载体中的药物成分,该药物载体包括但不限于水或乙醇等介质。该电喷雾雾化系统100可包括储液仓10、液体流路15、控制模块2、高压模块7、注射泵8。储液仓10用于收容雾化液200,注射泵8用于对储液仓10施加压力,以压迫储液仓10内的雾化液200经由液体流路15喷出。高压模块7用于对储液仓10内的雾化液200施加高电压,使电荷聚集在液滴上,当液滴表面的电荷超过了其所能达到的极限时,就会驱使液滴发生爆破而形成的更小的液滴,从而实现对雾化液200的雾化。本发明通过电喷雾技术对雾化液200进行雾化,雾化过程是低温(通常为常温)过程,对生物活性成分无影响,从而避免由于高温而造成生物活性成分的变性。此外,由于电喷雾技术是通过液滴内部的静电斥力实现雾化,从而可通过调节雾化液200的电导率来控制爆裂后的气溶胶粒径。通常,雾化液200的电导率越大,爆裂后形成的颗粒物越小,即雾化后形成的气溶胶粒径越小。在一些实施例中,雾化液200的电导率范围为20~20000μΩ-1/cm,在该范围内,能够获得较合适的气溶胶粒径。1-2 show an electrospray atomization system 100 in some embodiments of the present invention. The overall structure of the electrospray atomization system 100 is small, easy to carry and use, and it can be applied to the atomization of an atomizing liquid 200 . The atomized liquid 200 may include a medical solution, which generally includes a drug carrier and a drug component added to the drug carrier, and the drug carrier includes but not limited to water or ethanol and other media. The electrospray atomization system 100 may include a liquid storage tank 10 , a liquid flow path 15 , a control module 2 , a high pressure module 7 , and a syringe pump 8 . The liquid storage bin 10 is used to store the atomized liquid 200 , and the syringe pump 8 is used to apply pressure to the liquid storage bin 10 to press the atomized liquid 200 in the liquid storage bin 10 to be ejected through the liquid flow path 15 . The high-voltage module 7 is used to apply a high voltage to the atomized liquid 200 in the liquid storage tank 10, so that the charge accumulates on the droplet. When the charge on the surface of the droplet exceeds the limit that it can achieve, it will drive the droplet to generate The smaller liquid droplets formed by the blasting can realize the atomization of the atomized liquid 200 . The present invention atomizes the atomizing liquid 200 through the electrospray technology, and the atomization process is a low-temperature (usually room temperature) process, which has no effect on the bioactive components, thereby avoiding the denaturation of the bioactive components due to high temperature. In addition, since the electrospray technology achieves atomization through the electrostatic repulsion inside the liquid droplets, the particle size of the aerosol after bursting can be controlled by adjusting the conductivity of the atomized liquid 200 . Generally, the greater the conductivity of the atomized liquid 200, the smaller the particles formed after bursting, that is, the smaller the particle size of the aerosol formed after atomization. In some embodiments, the conductivity of the atomized liquid 200 ranges from 20 to 20000 μΩ −1 /cm, and within this range, a more suitable aerosol particle size can be obtained.

注射泵8可包括活塞缸84、可移动地设置于活塞缸84中的活塞83、与活塞83连接的活塞杆82以及与活塞杆82连接的电机81。活塞缸84内形成有一气压腔80,该气压腔80与储液仓10相连通,注射泵8可经由气压腔80对储液仓10施加压力。在一些实施例中,该电极81可以为步进电机,该活塞杆82可以为丝杆。电机81与控制模块2连接,电机81能够在控制模块2的控制下转动,进而通过活塞杆82带动活塞83在活塞缸84中向上移动,活塞83向上移动的过程中会压缩气压腔80的体积,从而产生一气体压强,该气体压强作用于储液仓10内的雾化液200,将雾化液200从液体流路15推出。从液体流路15流出的液滴具有高压特性,大量电荷聚集在液滴上后会由于静电斥力而发生爆裂而形成较小的液滴,从而完成雾化。每次雾化过程的雾化量受到气压腔80的压缩体积控制,压缩体积越大,则推出溶液的质量越多,对应是较大的雾化量。因此,可通过电机81控制气压腔80的压缩体积,从而控制液体推出的质量,实现定量雾化。The syringe pump 8 may include a piston cylinder 84 , a piston 83 movably disposed in the piston cylinder 84 , a piston rod 82 connected to the piston 83 , and a motor 81 connected to the piston rod 82 . An air pressure chamber 80 is formed in the piston cylinder 84 , and the air pressure chamber 80 communicates with the liquid storage chamber 10 , and the syringe pump 8 can apply pressure to the liquid storage chamber 10 through the air pressure chamber 80 . In some embodiments, the electrode 81 can be a stepper motor, and the piston rod 82 can be a screw rod. The motor 81 is connected to the control module 2, the motor 81 can rotate under the control of the control module 2, and then the piston rod 82 drives the piston 83 to move upward in the piston cylinder 84, and the piston 83 compresses the volume of the air chamber 80 during the upward movement , so as to generate a gas pressure, which acts on the atomized liquid 200 in the liquid storage bin 10 to push the atomized liquid 200 out of the liquid flow path 15 . The liquid droplets flowing out from the liquid flow path 15 have high voltage characteristics, and after a large amount of charges are accumulated on the liquid droplets, they will burst due to electrostatic repulsion to form smaller liquid droplets, thereby completing the atomization. The amount of atomization in each atomization process is controlled by the compression volume of the air pressure chamber 80 , the larger the compression volume, the more mass of the pushed solution, which corresponds to a larger atomization amount. Therefore, the compression volume of the air pressure chamber 80 can be controlled by the motor 81, thereby controlling the quality of the liquid pushed out and realizing quantitative atomization.

液体流路15可包括与储液仓10相连通的至少一个微流道11以及与该至少一个微流道11相连通的至少一个喷头14,储液仓10内的雾化液200经由微流道11后再从喷头14挤出。该微流道11可用于控制泵送液体的液体流量。具体地,微流道11可以有一个或多个,可根据雾化液200在微流道11中运动的阻力系数选择合适数量的微流道11以及微流道11的流通截面积,来控制泵送液体的液体流量。当微通道11的结构确定时,其供液的液体流量由气压腔80内的气体压强所决定,可通过控制气压腔80内的气体压强来控制供液的液体流量。在一些实施例中,该电喷雾雾化系统100还可包括与气压腔80相连通的气压传感器9,用于检测气压腔80内的气体压强。气压传感器9可与控制模块2连接,在雾化过程中,通过气压传感器9对气压腔80内的气体压强进行检测并可将该检测信号反馈至控制模块2,控制模块2可根据该检测信号控制电机81的转速,以保证气压腔80内的气体压强保持稳定,从而实现对雾化液雾化流量的控制,实现雾化液的定量雾化。The liquid flow path 15 may include at least one micro-channel 11 communicated with the liquid storage bin 10 and at least one spray head 14 communicated with the at least one micro-channel 11 , the atomized liquid 200 in the liquid storage bin 10 passes through the micro-flow Road 11 is extruded from nozzle 14 again. The microchannel 11 can be used to control the liquid flow rate of the pumped liquid. Specifically, there may be one or more micro-channels 11, and the appropriate number of micro-channels 11 and the cross-sectional area of the micro-channels 11 can be selected according to the resistance coefficient of the atomized liquid 200 moving in the micro-channels 11 to control The liquid flow rate of the pumped liquid. When the structure of the microchannel 11 is determined, the liquid flow rate of the liquid supply is determined by the gas pressure in the air pressure chamber 80 , and the liquid flow rate of the liquid supply can be controlled by controlling the gas pressure in the air pressure chamber 80 . In some embodiments, the electrospray atomization system 100 may further include an air pressure sensor 9 communicating with the air pressure chamber 80 for detecting the gas pressure in the air pressure chamber 80 . The air pressure sensor 9 can be connected with the control module 2. During the atomization process, the air pressure sensor 9 can detect the gas pressure in the air pressure chamber 80 and can feed back the detection signal to the control module 2. The control module 2 can use the detection signal to The rotation speed of the motor 81 is controlled to ensure that the gas pressure in the air pressure chamber 80 remains stable, so as to realize the control of the atomization flow rate of the atomization liquid and realize the quantitative atomization of the atomization liquid.

在一些实施例中,微流道11的长度可以为5~50mm。微流道11的轴线方向可与喷头14的轴线方向平行。优选地,喷头14有多个,多个喷头14可呈阵列分布。通过调整喷头14的孔径,可对雾化后形成的气溶胶的粒径大小进行调控。在一些实施例中,液体流路15还可包括连通于该至少一个微流道11和该多个喷头14之间的汇流通道13,储液仓10内的雾化液200经由微流道11流至汇流通道13,然后再经由喷头14挤出。In some embodiments, the length of the micro-channel 11 may be 5-50 mm. The axial direction of the micro-channel 11 may be parallel to the axial direction of the nozzle 14 . Preferably, there are multiple shower heads 14, and the multiple shower heads 14 may be distributed in an array. By adjusting the aperture of the nozzle 14, the particle size of the aerosol formed after atomization can be regulated. In some embodiments, the liquid flow path 15 may also include a confluence channel 13 connected between the at least one micro-channel 11 and the plurality of nozzles 14, and the atomized liquid 200 in the liquid storage bin 10 passes through the micro-channel 11 Flow to the confluence channel 13, and then extrude through the nozzle 14.

该电喷雾雾化系统100还可包括分别与高压模块7电连接的高压电极71和接地电极73。高压电极71可设置于储液仓10的内表面,从而使高压电极71与储液仓10内的雾化液200直接接触连接,这样可使整个雾化液200都带有高压电。在雾化过程中,在高压电极71和接地电极73之间施加一高电压(即雾化电压),该高电压可以为正高电压并可约为3kV~5kV,然后控制电机81转动,压缩气压腔80以压迫雾化液200从喷头14挤出,实现雾化。在雾化过程中,毫米级的大液滴通过静电作用形成纳米级的小液滴。通过对雾化液200的电导率、雾化电压、供液速度、表面张力、喷头14的孔径等参数进行调控,可以对雾化后生成的气溶胶的粒径进行控制和优化,产生的气溶胶的单分散性也较强。在应用该电喷雾雾化系统100对药液进行雾化时,可根据药液在人体的沉积位置需要来控制雾化后的气溶胶的粒径。此外,由于药物分子一直处于溶液中,其分散过程也是伴随溶液的,所以其药效和在溶液中的浓度均匀性不受到影响。The electrospray atomization system 100 may further include a high voltage electrode 71 and a ground electrode 73 electrically connected to the high voltage module 7 . The high-voltage electrode 71 can be arranged on the inner surface of the liquid storage bin 10, so that the high-voltage electrode 71 is in direct contact with the atomized liquid 200 in the liquid storage bin 10, so that the entire atomized liquid 200 can be charged with high voltage. During the atomization process, a high voltage (i.e. atomization voltage) is applied between the high-voltage electrode 71 and the ground electrode 73. The high voltage can be a positive high voltage and can be about 3kV to 5kV, and then the motor 81 is controlled to rotate and compress the air pressure. The chamber 80 presses the atomizing liquid 200 to squeeze out from the nozzle 14 to realize atomization. During the atomization process, millimeter-scale large droplets form nanometer-scale small droplets through electrostatic interaction. By adjusting the parameters such as the conductivity of the atomizing liquid 200, atomizing voltage, liquid supply speed, surface tension, and the aperture of the nozzle 14, the particle size of the aerosol generated after atomization can be controlled and optimized, and the generated aerosol The monodispersity of the sol is also strong. When the electrospray atomization system 100 is used to atomize the liquid medicine, the particle size of the atomized aerosol can be controlled according to the deposition position of the liquid medicine in the human body. In addition, since the drug molecule is always in the solution, its dispersion process is also accompanied by the solution, so its drug effect and concentration uniformity in the solution are not affected.

进一步地,该电喷雾雾化系统100还可包括与高压模块7电连接的牵引电极72,以使雾化后的气溶胶能够更好的飞出。牵引电极72可与该多个喷头14的喷出口对应设置,通过牵引电极72施加高压牵引,同时保持内部部件通过接地电极73接地,使得从喷头14挤出的气溶胶加速飞出。Further, the electrospray atomization system 100 may further include a pull electrode 72 electrically connected to the high voltage module 7, so that the atomized aerosol can fly out better. The pulling electrode 72 can be arranged corresponding to the nozzles of the plurality of nozzles 14, and the high voltage pulling is applied through the pulling electrode 72, while keeping the internal components grounded through the grounding electrode 73, so that the aerosol extruded from the nozzles 14 is accelerated to fly out.

在一些实施例中,该电喷雾雾化系统100还可包括与控制模块2连接的监控模块4。当雾化正常时,雾化后的气溶胶会带走部分电荷,即产生微电流(一般在nA和μA级别)。当雾化不正常时,则存在电流过小或电流不稳定的情况。因此,在雾化过程中,可通过监控模块4对高压电极71间的电流进行动态监控,在电流不稳定时进行报错和预警。通常,当电流突然出现增大时,则可能是由于内部组件短路发生放电;当电流突然出现减小时,则可能是由于供液不足或管道堵塞,没有形成良好的雾化过程。In some embodiments, the electrospray atomization system 100 may further include a monitoring module 4 connected to the control module 2 . When the atomization is normal, the atomized aerosol will take away part of the charge, that is, generate a micro current (generally at the nA and μA level). When the atomization is abnormal, the current is too small or the current is unstable. Therefore, during the atomization process, the current between the high-voltage electrodes 71 can be dynamically monitored through the monitoring module 4, and an error report and early warning can be performed when the current is unstable. Usually, when the current suddenly increases, it may be due to short-circuit of internal components and discharge; when the current suddenly decreases, it may be due to insufficient liquid supply or blocked pipes, and a good atomization process has not been formed.

此外,在单次雾化完成后,喷头14中会残留部分液体,随着液体中的溶剂挥发,溶质可能会堵塞喷头。因此在雾化完成后,可通过控制模块2控制电机81反向转动,以带动活塞83向下移动进行回退,使气压腔80的体积增大,从而使得气压腔80内形成负压,进而将喷头14中的液体吸回到储液仓10。在一些实施例中,该负压的范围可以为-0.5~10kPa。进一步地,还可在微流道11处设置单向阀12,以防止空气进入储液仓10内,保持储液仓10内的持续负压。该单向阀12可设置于汇流通道13中并与微流道11一一对应设置。In addition, after a single atomization is completed, some liquid will remain in the nozzle 14, and as the solvent in the liquid volatilizes, the solute may block the nozzle. Therefore, after the atomization is completed, the control module 2 can be used to control the motor 81 to rotate in reverse, so as to drive the piston 83 to move downward and retreat, so that the volume of the air pressure chamber 80 increases, so that a negative pressure is formed in the air pressure chamber 80, and then The liquid in the spray head 14 is sucked back into the liquid storage tank 10 . In some embodiments, the negative pressure may range from -0.5 to 10 kPa. Furthermore, a one-way valve 12 can also be provided at the micro-channel 11 to prevent air from entering the liquid storage chamber 10 and maintain a continuous negative pressure in the liquid storage chamber 10 . The one-way valve 12 can be arranged in the confluence channel 13 and correspond to the micro-channels 11 one by one.

随着雾化技术的发展,待雾化的雾化液200包括多种特性,例如:1、部分药液只能保持在较低温度下,如部分吸入式疫苗需要保持在2~8℃;2、部分待雾化的药物不溶于溶剂中,呈现悬浊液的状态。因此,较佳地,该电喷雾雾化系统100还可包括与控制模块2连接的制冷模块3和搅拌器16。制冷模块3可用于对储液仓10内的雾化液200进行制冷和温度控制,使雾化液200可以短期存储在储液仓10内。在一些实施例中,制冷模块3可包括半导体制冷片,其可设置于储液仓10的外表面。该搅拌器16可包括设置于雾化液200中的磁控混合转子,该磁控混合转子可通过外部的磁场激励在雾化液200中持续旋转,防止悬浊液中的药物成分的团聚和沉淀。通过制冷模块3和搅拌器16,可使得待雾化的雾化液200包含尽可能多的种类。With the development of atomization technology, the atomized liquid 200 to be atomized includes various characteristics, for example: 1. Some liquid medicines can only be kept at a relatively low temperature, for example, some inhaled vaccines need to be kept at 2-8°C; 2. Part of the drug to be nebulized is insoluble in the solvent and presents a state of suspension. Therefore, preferably, the electrospray atomization system 100 may further include a refrigeration module 3 and a stirrer 16 connected to the control module 2 . The refrigeration module 3 can be used to cool and control the temperature of the atomized liquid 200 in the liquid storage bin 10 , so that the atomized liquid 200 can be stored in the liquid storage bin 10 for a short time. In some embodiments, the cooling module 3 may include a semiconductor cooling chip, which may be disposed on the outer surface of the liquid storage bin 10 . The agitator 16 may include a magnetically controlled mixing rotor arranged in the atomized liquid 200, and the magnetically controlled mixed rotor may be continuously rotated in the atomized liquid 200 by an external magnetic field to prevent the agglomeration and precipitation. Through the refrigeration module 3 and the agitator 16, the atomized liquid 200 to be atomized can contain as many kinds as possible.

在一些实施例中,该电喷雾雾化系统100还可包括外壳1、吸嘴5、电源6以及控制开关17。外壳1呈内部中空的筒状,用于收容储液仓10、液体流路15、控制模块2、制冷模块3、监控模块4、电源6、高压模块7、注射泵8以及气压传感器9。外壳1的一侧开设有一吸嘴口18,吸嘴5安装于该吸嘴口18处,外壳1内雾化后形成的气溶胶经由吸嘴5流出,供用户吸食。吸嘴5可包括与外壳1的内部相连通的第一吸嘴部51以及与该第一吸嘴部51相连通的第二吸嘴部52。第一吸嘴部51可呈喇叭口状,其孔径从朝向外壳1内的一端至与第一吸嘴部51相连通的一端逐渐减小,从而可使得气溶胶更加集中。第二吸嘴部52可呈直筒状,其横截面尺寸较小,便于用于含在口中。In some embodiments, the electrospray atomization system 100 may further include a housing 1 , a suction nozzle 5 , a power source 6 and a control switch 17 . The housing 1 is hollow and cylindrical, and is used to accommodate the liquid storage tank 10 , the liquid flow path 15 , the control module 2 , the refrigeration module 3 , the monitoring module 4 , the power supply 6 , the high pressure module 7 , the syringe pump 8 and the air pressure sensor 9 . One side of the casing 1 is provided with a nozzle opening 18, where the suction nozzle 5 is installed, and the aerosol formed after atomization in the casing 1 flows out through the suction nozzle 5 for the user to inhale. The nozzle 5 may include a first nozzle part 51 communicating with the inside of the housing 1 and a second nozzle part 52 communicating with the first nozzle part 51 . The first suction nozzle part 51 may be in the shape of a bell mouth, and its aperture gradually decreases from the end facing the inside of the housing 1 to the end communicating with the first suction nozzle part 51, so that the aerosol can be more concentrated. The second suction nozzle part 52 can be in the shape of a straight cylinder with a small cross-sectional dimension, which is convenient for being contained in the mouth.

电源6与控制模块2电连接并可向控制模块2供电。控制开关17可设置于外壳1上,用于接收用户的操作并控制控制模块2的工作,例如雾化工作的启停等。再例如,也可通过控制开关17设置每次输入液体的量来实现雾化液200的定量雾化。The power supply 6 is electrically connected to the control module 2 and can supply power to the control module 2 . The control switch 17 can be arranged on the housing 1, and is used to receive user's operation and control the operation of the control module 2, such as start and stop of the atomization work and the like. For another example, the quantitative atomization of the atomized liquid 200 can also be realized by controlling the switch 17 to set the amount of liquid input each time.

应用案例:基于图1的结构搭建的电喷雾雾化系统100对雾化液200进行雾化,该雾化液200采用10%的葡萄糖水溶液,由于葡萄糖水溶液不导电,所以添加氯化钠作为电导率调节物质,调节溶液的电导率约为400μΩ-1/cm。雾化后产生的气溶胶的粒径使用扫描电迁移率粒径谱仪(SMPS,美国TSI公司)测量,粒径分布如图3所示。由该粒径分布图可看出,雾化后气溶胶颗粒物的粒径都在200nm以下,颗粒物的峰值粒径在40nm左右。Application case: The electrospray atomization system 100 built on the basis of the structure in Figure 1 atomizes the atomization liquid 200. The atomization liquid 200 uses 10% glucose aqueous solution. Since the glucose aqueous solution is non-conductive, sodium chloride is added as the conductivity rate-regulating substance, and adjust the conductivity of the solution to be about 400μΩ -1 /cm. The particle size of the aerosol produced after atomization was measured by a scanning electric mobility particle size spectrometer (SMPS, TSI Company, USA), and the particle size distribution is shown in FIG. 3 . It can be seen from the particle size distribution diagram that the particle size of the aerosol particles after atomization is all below 200nm, and the peak particle size of the particles is about 40nm.

上述应用案例说明:电喷雾雾化系统100可以实现雾化液200的雾化,雾化后的颗粒可以达到几十纳米的水平,更有助于其进入肺部深处而获得更好的吸收。The above application cases illustrate that the electrospray atomization system 100 can realize the atomization of the atomized liquid 200, and the atomized particles can reach the level of tens of nanometers, which is more conducive to its penetration into the deep lungs and better absorption .

图4示出了微流道11的长度为20mm时的流量与压降关系图。由图可看出,在不同驱动压力条件下(压降Pa)通过的液体流量是保持稳定的,且随着驱动压力的增加,液体流量也持续增加。这样通过控制驱动压力如500Pa时,可以稳定控制工业流量在1ml/min。FIG. 4 shows the relationship between the flow rate and the pressure drop when the length of the micro-channel 11 is 20 mm. It can be seen from the figure that the liquid flow through under different driving pressure conditions (pressure drop Pa) remains stable, and as the driving pressure increases, the liquid flow continues to increase. In this way, by controlling the driving pressure such as 500Pa, the industrial flow rate can be stably controlled at 1ml/min.

可以理解地,上述各技术特征可以任意组合使用而不受限制。It can be understood that the above technical features can be used in any combination without limitation.

以上实施例仅表达了本发明的优选实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制;应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,可以对上述技术特点进行自由组合,还可以做出若干变形和改进,这些都属于本发明的保护范围;因此,凡跟本发明权利要求范围所做的等同变换与修饰,均应属于本发明权利要求的涵盖范围。Above embodiment has only expressed the preferred embodiment of the present invention, and its description is comparatively specific and detailed, but can not therefore be interpreted as the limitation of patent scope of the present invention; It should be pointed out that, for those of ordinary skill in the art, in Under the premise of not departing from the concept of the present invention, the above-mentioned technical features can be freely combined, and some deformations and improvements can also be made, which all belong to the protection scope of the present invention; therefore, all equivalent transformations made with the scope of the claims of the present invention All modifications and modifications shall fall within the scope of the claims of the present invention.

Claims (19)

1. An electrospray atomising system comprising:
a liquid storage bin (10) for storing atomized liquid (200);
at least one micro-channel (11) and at least one spray head (14) which are sequentially communicated with the liquid storage bin (10);
a high voltage electrode (71) electrically connected to the atomized liquid (200) in the liquid storage chamber (10) for applying high voltage to the atomized liquid (200); and
-a syringe pump (8), the syringe pump (8) comprising a pneumatic chamber (80) in communication with the reservoir (10), the syringe pump (8) being capable of applying pressure to the reservoir (10) via the pneumatic chamber (80) to force the atomized liquid (200) in the reservoir (10) to be ejected from the at least one ejection head (5) via the at least one micro-channel (11).
2. The electrospray atomisation system according to claim 1 wherein the high voltage power is between 3kV and 5kV.
3. Electrospray atomisation system according to claim 1, characterized in that the high voltage electrode (71) is arranged on the inner surface of the reservoir (10) and is in direct contact connection with the atomising liquid (200) in the reservoir (10).
4. Electrospray atomisation system according to claim 1, characterized in that it further comprises a control module (2) and a high voltage module (7) and a power supply (6) electrically connected to the control module (2), respectively, the high voltage electrode (71) being electrically connected to the high voltage module (7).
5. Electrospray atomisation system according to claim 4, characterized in that the injection pump (8) comprises a motor (81), a piston rod (82), a piston (83) and a piston cylinder (84), the piston cylinder (84) having the pneumatic chamber (80) formed therein; the motor (81) is electrically connected with the control module (2), and the motor (81) drives the piston (83) to move in the piston cylinder (84) through the piston rod (82) so as to compress the volume of the air pressure cavity (80), so that pressure is applied to the liquid storage bin (10).
6. Electrospray atomisation system according to claim 5 characterized in that it further comprises a gas pressure sensor (9) in communication with the gas pressure chamber (80) for detecting the gas pressure inside the gas pressure chamber (80).
7. Electrospray atomisation system according to claim 6, characterized in that the air pressure sensor (9) is electrically connected to the control module (2); the control module (2) can receive a detection signal from the air pressure sensor (9) and control the rotating speed of the motor (81) according to the detection signal.
8. Electrospray atomisation system according to claim 4 characterized in that it further comprises a ground electrode (73) and a traction electrode (72) electrically connected to the high voltage module (7), respectively; the traction electrode (72) is provided in correspondence with the ejection port of the at least one ejection head (5) and is used for applying high-voltage traction to the aerosol ejected from the at least one ejection head (5).
9. Electrospray atomisation system according to claim 1, characterized in that it further comprises a monitoring module (4) for monitoring the current between the high voltage electrodes (71) and for reporting errors and pre-warnings when the current is unstable.
10. Electrospray atomisation system according to claim 1, characterized in that the injection pump (8) is also adapted to retract after atomisation is completed, causing a negative pressure to be formed in the pneumatic chamber (80), sucking the liquid in the at least one spray head (14) back into the reservoir (10).
11. The electrospray atomisation system according to claim 10 wherein the negative pressure is in the range of-0.5 to 10kPa.
12. Electrospray atomisation system according to claim 10 characterized in that it further comprises at least one-way valve (12) provided to the at least one micro channel (11) to maintain a continuous negative pressure inside the reservoir (10).
13. Electrospray atomisation system according to claim 1, characterized in that it further comprises a refrigeration module (3) arranged in the reservoir (10) for temperature-controlled cooling of the atomising liquid (200) in the reservoir (10).
14. Electrospray atomisation system according to claim 13, characterized in that the refrigeration module (3) comprises a semiconductor refrigeration tablet, the refrigeration module (3) being arranged on the outer surface of the reservoir (10).
15. Electrospray atomisation system according to claim 1 characterized in that it further comprises a stirrer (16) arranged in the reservoir (10) for stirring the atomising liquid (200) in the reservoir (10).
16. Electrospray atomising system according to claim 15, characterized in that the stirrer (16) comprises a magnetically controlled mixing rotor.
17. Electrospray atomisation system according to any of the claims 1-16, characterized in that the electrical conductivity of the atomisation liquid (200) is in the range of 20-20000 μΩ -1 /cm。
18. Electrospray atomisation system according to any of the claims 1-16, characterized in that the spray heads (5) are arranged in an array of a plurality of spray heads (5).
19. Electrospray atomising system according to any of the claims 1-16, characterized in that it further comprises a housing (1) for housing the reservoir (10), the high voltage electrode (71) and the syringe pump (8) and a suction nozzle (5) provided to the housing (1) for aerosol output.
CN202111289653.2A 2021-11-02 2021-11-02 Electrospray atomization system Pending CN116059479A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535183A (en) * 2001-06-22 2004-10-06 ������������� Electrostatic atomisation device
CN207740067U (en) * 2017-08-09 2018-08-17 华中科技大学无锡研究院 A kind of urea pumping system
CN110812628A (en) * 2019-11-27 2020-02-21 江苏大学 Medical atomizing device based on multi-micron-hole array electrostatic atomization
CN113198073A (en) * 2021-04-15 2021-08-03 中国人民解放军总医院第二医学中心 Atomizing inhaler for infectious diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535183A (en) * 2001-06-22 2004-10-06 ������������� Electrostatic atomisation device
CN207740067U (en) * 2017-08-09 2018-08-17 华中科技大学无锡研究院 A kind of urea pumping system
CN110812628A (en) * 2019-11-27 2020-02-21 江苏大学 Medical atomizing device based on multi-micron-hole array electrostatic atomization
CN113198073A (en) * 2021-04-15 2021-08-03 中国人民解放军总医院第二医学中心 Atomizing inhaler for infectious diseases

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