CN1160503A - Soluble concentrated frozen/refrigerated calcium preparation comprising calcium citrate-malate and process for producing the same - Google Patents
Soluble concentrated frozen/refrigerated calcium preparation comprising calcium citrate-malate and process for producing the same Download PDFInfo
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- CN1160503A CN1160503A CN96120463A CN96120463A CN1160503A CN 1160503 A CN1160503 A CN 1160503A CN 96120463 A CN96120463 A CN 96120463A CN 96120463 A CN96120463 A CN 96120463A CN 1160503 A CN1160503 A CN 1160503A
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Abstract
A soluble enriched frozen or refrigerated calcium preparation comprising calcium citrate-malate obtained by reacting citric acid, malic acid and a calcium salt under the specific conditions to obtain calcium citrate-malate, refrigerating or quickly freezing it, and if necessary drying the frozen product.
Description
The invention relates to the solubility that contains citric acid-calcium malate concentrates and to freeze or freezing calcium preparation and produce this freezing or the method for freezing calcium preparation.More particularly, be to concentrate about the production solubility to freeze or the method for freezing calcium preparation, this method comprise will have the calcium reaction of a certain proportion of citric acid (or sodium citrate) and malic acid (natrium malicum) and specified quantitative obtaining a kind of solubility calcium preparation that contains citric acid-calcium malate, and freezing or this solution of quick freezing with in the solution nonactive calcium and permanently keep its solubility.
The solubility that contains citric acid-calcium malate produced according to the invention concentrates calcium preparation, can be used for any field of needs picked-up calcium, but finds to be effectively applied to food and drug world especially.
Many Japaneses are tending towards calcium deficiency, thereby the supply of calcium becomes one of important planning of ministry of Health and Welfare.And along with the fast development of aging society, a kind of product occurring can effectively absorb calcium with dissolved state as the calcium in the milk, has now become global urgent needs.In this case, to the solubilization method of calcium, some noticeable suggestion has been proposed.For example, Japanese Patent No. 1,836,036 has reported a kind of method, wherein 70% or following sodium citrate and 30% or above natrium malicum be dissolved in the water, in this solution, add the normal potassium chloride of corresponding chemical molecule then and react it, the crystalline deposit thing that makes is isolated and drying under the temperature of regulation.This method can be considered the best way as dissolved slightly calcium salt solubilising.Yet this system remains unsatisfied as realizing the available calcium preparation of supply of commodities.
In view of the foregoing, the inventor had once made broad research a kind ofly can be provided the method for such solubility calcium preparation and easy technology is arranged for seeking, and finally successfully obtains the present invention.
According to the solubility calcium preparation that contains citric acid-calcium malate provided by the present invention, be considered to have following basic molecular structure (hydrogen bond):
Citric acid is a kind of organic acid in kerbs (Krebs) circulation, increases the water solublity of calcium citrate, not only to introducing calcium in the Food ﹠ Drink, and calcium is applied to drug world all is of great importance.For require neutral or near the neutral PH situation under the beverage of transparent this type, be useful especially.And it also has other advantages, when promptly adding calcium in other food, needn't worry to produce the distinctive abnormal smells from the patient of calcium.And, since its dissolubility and this calcium preparation in medicine for coming into the picture.
Be the physical property of this soluble calcium below: white crystalline powder (neutral powder):
No taste and odorlessness.0.5g calcium powder is dissolvable in water in 20 ℃ of water of 100ml (PH=6-6.5).
Form:
Theoretical value measured value * calcium citrate 42.24% 40.48%
Calcium malate 53.76% 51.52%
Calcium consumption 22.68% 21.73%
Water 4.0% 8.0% white crystal fine powders, its acid/calcium=2/1
Tart flavour road and odorlessness.1.6g fine powder is dissolvable in water in 20 ℃ of water of 100ml (PH=3.9-4.0).
Theoretical value measured value *
Calcium citrate 30.83% 35.3%
Calcium malate 39.05% 47.7%
Calcium consumption 16.51% 16.0%
Water 4.0% 1.0% solution, its acid/calcium=2/1
Slightly tart flavour and scent of be not though there is odour nuisance.10.0g be to be dissolvable in water in 20 ℃ of water of 100ml (PH=3.9-4.0).
Theoretical value measured value *
Calcium citrate 9.3% 9.56%
Calcium malate 11.8% 13.4%
Calcium consumption 5.0% 5.0%
Water 70.9% 72.04%
* be to get according to the test of Japan canned article test association
Result as research, the present invention has successfully obtained a kind of solubility and has concentrated and to freeze or freezing calcium preparation, preparation method is by dissolving 99% or still less citric acid or sodium citrate, with 10% or more malic acid or natrium malicum in water, to addition wherein is 1/2 calcium of said acid or chemical compound sum, and the freezing or prepared solution of quick freezing.Tangible advantage of this preparation is, it can be with the frozen state supply, or in case of necessity as the dry products supply.
Can be understood more fully actual practice of the present invention by consulting following examples, yet these examples are to be used to illustrate the present invention rather than to limit the scope of the invention.Embodiment 1
With the 460g citric acid, after this 540g malic acid and 500g dissolution of calcium carbonate are carried out quick disc type with this solution immediately and are freezed (pan-frozen) in 2.5 premium on currency.After 6 days, this disc type frozen product taken out from refrigerator and stir thawing with the water of following amount.Then the solution that obtains is heated to 45-55 ℃, best 45 ± 1 ℃.After reaching this temperature, add the normal calcium carbonate of corresponding chemical molecular, cause to form a kind of precipitate, obtain final products to this precipitate separation with 80-90 ℃ of following oven dry.
Starting mixt value neutralise mixt difference
Citric acid 460g 460g 0
Malic acid 540g 540g 0
Calcium carbonate 500g 730g 230g
Water 2,500ml 4, and 110ml 1,610m1
Amount to 4,000g 5, and 840ml 1,840ml
In starting mixt: calcium carbonate/total amount=12.55%; Ca content=50mg/g.In neutralise mixt: calcium carbonate/total amount=12.5%; Ca content=50mg/g.
The solubility test result of the said goods:
0.5%, PH=5.96, solvable
0.45%, PH=5.98, solvable
0.4%, PH=6.02, solvable
0.30%, PH=6.05, solvable embodiment 2
It is according to following prescription production that solubility concentrates calcium preparation:
55 ℃ of hot water 2 of starting mixt neutralise mixt difference, 500g 4,110 g 1,610g citric acid 460g 460g 0 malic acid 540g 540g 0 calcium carbonate 500g 730g 230g amounts to 4,000g 5,840ml 1, the 840g first method:
Stir after the reaction 1 hour-→ freeze → thawing → supply 1 after 1 day the calcium carbonate of 55 ℃ in the water of 610g difference → be heated to → supply with 230g difference → stirring 1 hour → dewater → disperse and freeze → 1 day postlyophilization result:
Water content=4.9-5.2%.
0.5%, PH5.8, solvable.Homogenize: 10000rpm/3 minute.Second method:
Freezing → thawing → supply 1 after 1 day the calcium carbonate of 45 ℃ of 55 ℃ of hot water of 610g difference → be heated to → supply with difference → stirring 1 hour → dewater → disperse → freeze → one day postlyophilization after the reaction immediately.The result:
Water content=2.9-5.0%
0.55, PH5.83, solvable
A kind of soluble preparation can derive from first method well, and is better but second method is considered to tone.With from beginning is just used and the situation of system, there is not any difference, said preparation solubilized to 0.5%.Embodiment 3
The sample formulation that will obtain with calcium carbonate (acid: calcium=2: 1), carry out time test and obtain following result: under the room temperature
Citric acid: malic acid
Preparation after be undissolved at 9: 1
After 8: 23 days is undissolved
After 7: 3 14 days is undissolved
After 6: 4 18 days is undissolved
After 5: 5 18 days is undissolved
After 4: 6 34 days is undissolved
After 3: 7 24 days is undissolved
After 2: 8 24 days is undissolved
Be undissolved under 37 ℃ after 1: 9 34 days
Citric acid: malic acid
After 8: 21 day is undissolved
After 7: 31 day is undissolved
After 6: 41 day is undissolved
After 5: 51 day is undissolved
After 4: 61 day is undissolved
After 3: 71 day is undissolved
After 2: 11 day is undissolved
After 1: 91 day is undissolved
Can find out that from above-mentioned situation all samples all is undissolved.Because citric acid: the sample of malic acid=9: 1 is insoluble after preparation, so do not put it in the calorstat.Embodiment 4
Sample formulation (the acid: calcium=2: 1), carry out time test, obtain following result: at normal temperatures that makes with calcium hydroxide
Citric acid: malic acid
After the preparation in 9: 1 is undissolved
After 8: 2 30 minutes is undissolved
After 7: 31 day is undissolved
After 6: 43 days is undissolved
After 5: 53 days is undissolved
After 4: 65 days is undissolved
After 3: 73 days is undissolved
After 2: 83 days is undissolved
Preparation after be undissolved 5 ℃ at 1: 9
Citric acid: malic acid
After 6: 45 days is undissolved
After 5: 55 days is undissolved
After 4: 65 days is undissolved
After 3: 75 days is undissolved
After 2: 85 days is undissolved
Citric acid: the sample of malic acid=9: 1 and 1: 9 all is undissolved after preparation; Citric acid: the sample of malic acid=7: 3, prepare and became undissolvedly in back 1 day, therefore the test that each sample is carried out all became undissolved later in 1 day.-18℃
Citric acid: malic acid
7: 3rd, undissolved
6: 4th, undissolved
2: 8th, undissolved
With citric acid: sample of malic acid=7: 3 (this sample became indissolubility in back 1 day in preparation) and citric acid: the sample (this sample became undissolved after 3 days) of malic acid=6: 4 and 2: 8, put into refrigerator and test.As a result, in sample remained in time course in the refrigerator, it is stable that the calcium salt in the sample keeps.Embodiment 5
Sample formulation (the acid: calcium=2: 1), carry out the time test, obtain following result: at normal temperatures that utilizes calcium oxide to make
Citric acid: malic acid
Measuring immediately after the preparation in 9: 1, is undissolved
Measuring immediately after the preparation in 8: 2, is undissolved
After 7: 32 days is undissolved
After 6: 42 days is undissolved
After 5: 52 days is undissolved
After 4: 62 days is undissolved
After 3: 72 days is undissolved
After 2: 82 days is undissolved
After 1: 92 days be undissolved 5 ℃
Citric acid: malic acid
After 7: 36 days is undissolved
After 6: 46 days is undissolved
After 5: 56 days is undissolved
After 4: 66 days is undissolved
After 3: 76 days is undissolved
After 2: 86 days is undissolved
After 1: 96 days is undissolved
Citric acid: the sample of malic acid=2: 8 and 1: 9 becomes obviously undissolved.Citric acid: the sample of malic acid=8: 2 and 9: 1 is insoluble after preparation, so it is no longer tested immediately.-18℃
Citric acid: malic acid
6: 4 solubilities
1: 9 solubility
With citric acid: the sample (becoming obviously insoluble) and the citric acid of malic acid=1: 9: the sample (this sample is transformed into the insoluble state of a kind of muddiness) of malic acid=6: 4 carries out the dissolubility test, wherein each sample was retained in the refrigerator through 6 days, melted then.At test period, it is stable that the calcium salt in the sample keeps in refrigerator.Embodiment 6
Calcium preparation (the acid: calcium=2: 1), make it under following different condition, to compare the dissolubility test that obtains by following prescription according to the method for embodiment 1.Prescription
Water 125g
Citric acid 23g
Malic acid 27g
Calcium carbonate 25g
Amount to 200g condition calcium content 1. room temperature preparation (20-25 ℃) 125mg/100g
After 8 days, 2.5%, solvable 2. cryopreparation (5 ℃) 150mg/100g
After 8 days, 3.0%, solvable 3. freeze preparation (18 ℃) 500mg/100g
After 8 days, 10.0%, solvable 4. drying agents (80 ℃), 1.6%, solvable 240mg/100g
By The above results as can be seen, freeze the state after preparation can keep its preparation, do not cause the activation of calcium salt, thereby its dissolubility can not lower.Room temperature preparation and frozen preparation have all reduced dissolubility slightly, but they can reach purpose of the present invention well.Because drying agent dries under the harsh temperatures condition, thereby its dissolubility (measuring according to calcium content) is to freeze 1/2 of agent dissolubility, but is higher than the dissolubility of room temperature preparation and frozen preparation.Embodiment 7
The sample formulation that will include sodium citrate, benzene fruit acid sodium and calcium lactate has been carried out the test of calcium dissolubility.Ca content in each sample is 50mg/g, and too, each sample is a solubility under 15g/100g.
Through freezed the sample that take out the back in 10 days from frigo, also solubility under 15g/100g, the sample after firm process is freezed to prepare.Calcium lactate is (calcium content=6.5mg/g), be soluble, but of the present inventionly freeze sample (Ca content=7.5mg/g) is soluble, and this shows the increase of dissolubility nearly 15% under 15g/100g under 5g/100g.
Sodium citrate: natrium malicum
Freeze at 9: 1 not dissolve after 1 day
Freeze at 8: 2 not dissolve 1.5g/100g after 1 day
Freeze at 7: 3 not dissolve (0.75mg/g) after 1 day
Freeze at 6: 4 not dissolve after 1 day
After 6: 44 days after 4 days after 4 days after 4 days after 4 days after 4 days
15g 10g 9g 3g 2g 1g
5: 5 insoluble---solvable
4: 6 insoluble--solvable-
3: 7 insoluble-solvable--
2: 8 insoluble solvable---
1: 9 insoluble solvable---
Can find out that from The above results dissolubility reduces in time and significantly.Be that ratio is 5: 5 a sample especially significantly, it is soluble under the 1.5g/100g situation in the morning, but promptly becomes undissolved after 9 hours.These results point out that the dissolubility of calcium is to keep stable when being under the frozen state in above-mentioned preparation.Embodiment 8
Every kind of calcium preparation that freezes in the following prescription is to carry out the dissolubility test after lyophilization.The preparation of each test sample is earlier each calcium preparation to be freezed 1 time-of-week at-20 ℃, then to its lyophilization through 24 hours.Sample 1
55 ℃ of hot water 330g
Citric acid 46g
Malic acid 54g
Calcium carbonate 56g
Amount to 486g
0.5% solvable sample 2
Water 259g
Citric acid 46g
Malic acid 54g
Calcium oxide 41g
Amount to 400g
1.4% does not dissolve; And 1.3% solubilized, sample 3
Water 370g
Citric acid 46g
Malic acid 54g
Calcium chloride 63g
Amount to 533g
1.7% does not dissolve; And 1.6% solubilized embodiment 9
In order to ensure its (citric acid/malic acid) ratio of a kind of sample 30-40 minute at normal temperatures be undissolved, but owing to freeze to become and can keep its dissolubility with cryodesiccated result, carried out following experiment.
(Ca content=50mg/g) system is from a prescription, and this prescription includes 62.5g water, 22.5g citric acid, 2.5g malic acid and 12.5g calcium carbonate (citric acid: malic acid=9: 1) for a kind of calcium solution.This solution once freezed, and melted then and the amount of solution is adjusted to 1.5g (0.75mg/g) to carry out the dissolubility test.The result confirms that sample is soluble.
Prepared solution is carried out same freezing, lyophilization and carry out dissolubility test.This powder product has calcium content 160mg/g (measured value) and water content 3.6%.The dissolubility test of this powder product is that it is soluble as 0.469g (0.75mg/g) preparation.Embodiment 10
Using soluble citric acid-benzene calcium citrate malate is in medicine:
Calcium ion is tending towards forming undissolved chemical compound with various aniones, and therefore calcium ion can not be mixed in liquid medium safely in many cases.In injection neutralization is inculcated, mix and be difficult especially, so drug manufacture producer often racks one's brains and manages calcium ion is sneaked in the medicine.Citric acid is used for this purpose, is the general practice.Also have such certain situation, be about to fluid and make ackd salt or special salt.
A kind of solubility that will contain citric acid-calcium malate concentrate freeze calcium preparation put into transfusion (Water-Electrolyte and vulcanize topping up/maintenances liquid), autoclave in 120 ℃ through sterilization in 15 minutes, carry out calcium deposit then and test.
It is 50mg/g and being retained in the refrigerator through 10 days that the preparation of test is adjusted to calcium content.The key component of this transfusion is glucose, sodium chloride, calcium chloride and potassium glycerinophosphate, and the PH of transfusion is 5.22, and its refraction index is 4.6%.
(1) 99.2g transfusion and 0.8g freeze the preparation (mixture of Ca content=40mg/100g)
Mixture has theoretical calcium content 40mg/100g, and this calcium content is used for transfusion than higher, and this mixture is sterilized through 15 minutes in 120 ℃ in autoclave.
Result: do not form precipitate.This mixture is transparent, does not demonstrate the difference with former transfusion.PH＝4.85。
(2) 99.8g transfusion and the 0.2g fine powder preparation (mixture of Ca content=4.2mg/100g)
The calcium content of this fine powder preparation is 210mg/g.With this mixture use with mixture (1) situation under the sterilization of same quadrat method.Result: do not form precipitation.Mixture is the same with original transfusion transparent, PH=5.35.Embodiment 11
With 680 sodium citrates, 800g natrium malicum and 740g calcium chloride are dissolved in the 1780g water, and quick freezing immediately.After 270 days, this frozen product is taken out from frigo, allow it melt (PH=5.92 of mother solution) naturally.
Utilize the solution that melts, make the calcareous bread of about 0.7kin by following prescription, weight 409g and high 15cm: prescription
Rich and powerful flour 280.0g
Sucrose 17.0g
Defatted milk powder 6.0g
Ordinary salt * 1.5g
Butter 11.0g
Dry yeast 3.0g
Melt solution * * 8.2g
Amount to 540.0g
* usually the blending amount of ordinary salt is 5g, and the consumption in the above-mentioned prescription is less, because the solution that has melted can produce salt by reaction.
* is because the Ca content in the solution is 50mg/g, thereby the calcium that is contained in about 0.7kin bread is 410mg (50mg * 8.2g=410mg), this means that every bread contains about 70g calcium.The calcium that every such bread can be supplied with every day well and lacked.Embodiment 12
Method according to embodiment 1 replaces calcium carbonate to make a kind of powderous preparations with calcium hydroxide, and produces a kind of sports beverage with this powderous preparations.
As follows, quick freezing product is melted, the water and the calcium hydroxide that add the difference amount subsequently neutralize, through after the necessary processing, with solution again row freeze and be dry.
Excess acid Supply Method neutralization method
Water 250g difference amount 80g 330g
Citric acid 46g 46g
Malic acid 54g 54g
Calcium hydroxide 50g difference amount 6g 56g
Amount to 400g 486g
Subsequently, can obtain the 120g powderous preparations.Can production sports beverage with this powderous preparations: prescription according to following prescription
Particulate sugar 53.44g
Fructose 35.00g
Citric acid 3.00g
Powderous preparations 4.50g
Potassium chloride 0.02g
Vitamin C 1.00g
Refined salt 1.00g
Flavorant 2.00g
Sodium bicarbonate 0.02g
Glycine 0.02g
Amount to 100.00g
Said mixture is dissolved in 5 premium on currency, and puts into (PH=3.86 in two 2.5 liters of PET (poly-to benzene=formic acid second=alcohol ester, as to be called for short polyester) bottle; Bx=6.08).This beverage can flavorant provides different fragrance by changing wherein.The calcium content of powderous preparations is 210mg/g.Because the cupful beverage contains the calcium of about 38mg/g,, two glasss of beverages replenish the calcium that was lacked in 1 day so just providing.Powderous preparations can be distributed into parcel, is convenient to copy band.The people who has calcium powder preparation parcel can open packing as required at any time, and powder is put in one glass of water, makes its dissolving make beverage embodiment 13
The quick freezing product of following composition solution is melted, utilize the solution that thaws to make flavoring agent (Italian local flavor).
Compositions
Water 250g
Citric acid 60g
Malic acid 40g
Calcium oxide 50g
Amount to 400g
Flavouring formula
(1) flavane glue 0.52g
Liquid fructose/glucose sugar 34.00g
Sodium glutamate 1.60g
Herba Alii fistulosi Bulbus Allii powder 4.00g
Flavoring agent mixture 7.20g
The broken Fructus Capsici 0.08g of rough lumber
The Herba Alii fistulosi 2.00g of chopping
Micronization black pepper 0.04g
Water 153.00g
(2) melt solution 30.00g
50GRN wine vinegar 23.20g
Ordinary salt 108.00g
(3) safflower oil 28.00g
Olive oil 8.00g
With each component (1) dissolving, 80 ℃ through 15 minutes, add each component (2) subsequently and be cooled to 30 ℃, and then add each component (3).This mixture is stirred and emulsifying, keep stirring, in the bottle of two 200ml that pack into then.Obtain bottled flavoring agent like this, every bottle contains about 1340mg calcium.Embodiment 14
Utilize the prepared calcic melt solution of embodiment 10, make a kind of kuzumochi (being similar to the arrowroot starch cake of pudding) sweet food by following prescription:
Prescription
Water 669.0g
Isomerized sugar 130.0g
Soybean oligo saccharide 70.0g
White sugar 15.0g
Enrichment polysaccharide 11.0g
Dextrin 90.0g
Melt solution 15.0g
Amount to 1000g
Bx＝27.0％；PH＝5.30
Make about 16 kuzumochi sweet foods, be divided in some containers, every 60g is heated to them 90 ℃, then through 10 minutes sterilization.The calcium content of every kuzumochi is 45mg/60g.Embodiment 15
Utilize the calcic melt solution among the embodiment 1, made a kind of fruit jelly by following prescription:
Prescription
Water 1380.4g
Solution 40.0g thaws
Isomerized sugar 260.0g
White sugar 260.0g
Polysaccharide 21.0g
Sucus Mali pumilae 34.0g
Acidulant 3.0g
Flavouring agent 1.0g
Coloring agent 0.6g
Amount to 2000.0g
Bx＝25.0％；PH＝3.79
The material of above-mentioned specified quantitative is packaged in some containers, forms 16 fruit jelly, every 120g sterilizes them 10 minutes at 80 ℃ then.The calcium content of fruit jelly is 120mg/120g, this explanation, and one day calcium deficiency just can be supplied well by an edible fruit jelly and be replenished.Embodiment 16
With the 15g sodium citrate, 15g natrium malicum and 40g calcium lactate are dissolved in the solution that forms in the 34g water, carry out quick freezing.The product that will freeze after 10 days takes out from frigo, allows nature melt the (PH=7.20g of mother solution.
Utilize the solution that melts,, make calcareous imoyokan (sweet the freezing that beans and Radix Ipomoeae are mixed and made into) by following prescription:
Prescription
Powdered agar 0.6g
Water 50.0g
Particulate sugar 24.0g
Isomerized sugar 3.0g
Melt solution 3.0g
Baked batata is stuck with paste 30.0g
Amount to 110.6g
Powdered agar is added in the entry, boil by boiling and make dissolving fully.After this add particulate sugar, solution is boiled boil again, add all the other materials subsequently continuously.Mixed solution is heated to 80 ℃, some containers of packing into then, sterilization and cooling.
Obtain 5 imoyokan, divide in a container of a neck formula 16 grams of packing into.The calcium content of mother solution is 50mg/g, uses this mother solution of 3g.This sweet freezing contains 22-26mg calcium/16g.Therefore, 3 said sweet freezing contain enough calcium to supply one day the calcium that is lacked.
Claims (14)
1. a solubility concentrates and freezes or freezing calcium preparation, it is characterized in that including citric acid one calcium malate.
2. as claimed in claim 1 freezing or freezing calcium preparation is characterized in that wherein the molecular weight ratio of calcium citrate and calcium malate is 3: 1-3: 81.
3. the production solubility that contains citric acid-calcium malate concentrates and freezes or the process of freezing calcium preparation, it is characterized in that comprising: malic acid more than the citric acid of dissolving 90% or 90% below or the sodium citrate and 10% or 10% or natrium malicum are in water, to addition wherein is 1/2 calcium of said acid or total amount of compound, and the freezing or quick freezing with the solution that makes.
4. the production solubility that contains citric acid-calcium malate concentrates and freezes or the process of freezing calcium preparation, it is characterized in that comprising: malic acid more than the citric acid of dissolving 90% or 90% below or the sodium citrate and 10% or 10% or natrium malicum are in water, to wherein adding the normal calcium of corresponding chemical molecule, and the freezing or quick freezing with the solution that makes.
5. the production solubility that contains citric acid one calcium malate concentrates and freezes or the process of freezing calcium preparation, it is characterized in that comprising: freezing or solution that quick freezing is produced according to claim 3, but melting chilling or that freeze if desired product, to wherein adding neutralization equivalent calcium, agitating solution is finished up to reaction, and then freezes this solution.
6. the production solubility that contains citric acid-calcium malate concentrates and freezes or the process of freezing calcium preparation, it is characterized in that comprising: freezing or quick freezing is according to any one solution of producing among the claim 3-5.
7. process as claimed in claim 6 is characterized in that wherein resultant frozen product is to use the vacuum method lyophilization.
8. the production solubility that contains citric acid-calcium malate concentrates the process of calcium preparation, it is characterized in that comprising: the frozen product that melts claim 4 or 5, the product that has melted dewatered to water content is about 50-60%, and it is carried out disc type hot-air dry or spray drying obtaining powderous preparations.
9. as any one described process among the claim 3-8, it is characterized in that wherein employed calcium is calcium carbonate, calcium hydroxide, calcium chloride, calcium oxide or calcium lactate.
10. as any one described process among the claim 3-9, it is characterized in that wherein quick freezing is at-18 ℃--carry out under 50 ℃.
11. as any one described process among the claim 3-9, it is characterized in that wherein freezing be lower than in temperature+10 ℃, best at+5 ℃--carry out under 9 ℃.
Be used for food or medicine 12. contain the concentrated calcium preparation of the solubility of citric acid-calcium malate.
13. purposes as claimed in claim 12 is characterized in that wherein food is beverage, dry products, confection, noodles, or health food.
14. purposes as claimed in claim 12 is characterized in that wherein medicine is injection or transfusion.
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| CN96120463A CN1160503A (en) | 1995-12-28 | 1996-11-06 | Soluble concentrated frozen/refrigerated calcium preparation comprising calcium citrate-malate and process for producing the same |
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| JP07-343226 | 1995-12-28 | ||
| CN96120463A CN1160503A (en) | 1995-12-28 | 1996-11-06 | Soluble concentrated frozen/refrigerated calcium preparation comprising calcium citrate-malate and process for producing the same |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086378C (en) * | 1999-11-23 | 2002-06-19 | 袁竟成 | Process for preparing calcium citrate malate by using citric acid, malic acid and calcium carbonate |
| CN102160648A (en) * | 2011-03-11 | 2011-08-24 | 陕西科技大学 | Rapidly disintegrating calcium tablets and preparation method thereof |
| CN101505731B (en) * | 2006-08-17 | 2011-11-16 | 宝洁公司 | Compositions comprising calcium citrate malate and methods for making the same |
| CN102987404A (en) * | 2012-08-21 | 2013-03-27 | 苏州谷力生物科技有限公司 | Food additive for promoting calcium absorption |
-
1996
- 1996-11-06 CN CN96120463A patent/CN1160503A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086378C (en) * | 1999-11-23 | 2002-06-19 | 袁竟成 | Process for preparing calcium citrate malate by using citric acid, malic acid and calcium carbonate |
| CN101505731B (en) * | 2006-08-17 | 2011-11-16 | 宝洁公司 | Compositions comprising calcium citrate malate and methods for making the same |
| CN102160648A (en) * | 2011-03-11 | 2011-08-24 | 陕西科技大学 | Rapidly disintegrating calcium tablets and preparation method thereof |
| CN102987404A (en) * | 2012-08-21 | 2013-03-27 | 苏州谷力生物科技有限公司 | Food additive for promoting calcium absorption |
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