CN116048025A - Method and system for automatically adjusting work order weighing sequence in MES (manufacturing execution system) drug manufacturing - Google Patents
Method and system for automatically adjusting work order weighing sequence in MES (manufacturing execution system) drug manufacturing Download PDFInfo
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- CN116048025A CN116048025A CN202310083496.2A CN202310083496A CN116048025A CN 116048025 A CN116048025 A CN 116048025A CN 202310083496 A CN202310083496 A CN 202310083496A CN 116048025 A CN116048025 A CN 116048025A
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- 238000005303 weighing Methods 0.000 title claims abstract description 66
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000007905 drug manufacturing Methods 0.000 title description 2
- 239000002994 raw material Substances 0.000 claims abstract description 234
- 238000006243 chemical reaction Methods 0.000 claims abstract description 87
- 230000002411 adverse Effects 0.000 claims abstract description 41
- 239000000463 material Substances 0.000 claims abstract description 36
- 239000003814 drug Substances 0.000 claims abstract description 15
- 238000012163 sequencing technique Methods 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 3
- 239000012856 weighed raw material Substances 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 238000004140 cleaning Methods 0.000 abstract description 13
- 230000007717 exclusion Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000009193 crawling Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/41865—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by job scheduling, process planning, material flow
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G19/00—Weighing apparatus or methods adapted for special purposes not provided for in the preceding groups
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/30—Computing systems specially adapted for manufacturing
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Abstract
The invention relates to a method for automatically adjusting the weighing sequence of a work order in MES medicine manufacture, which comprises the steps of extracting raw materials and weight required by production from the work order, establishing an adverse chemical reaction table among the raw materials, and weighing the raw materials in turn according to the total weight of the raw materials according to the order of more adverse chemical reactions with other raw materials. The invention can reduce the cleaning times of the material taking device and improve the weighing efficiency.
Description
Technical Field
The invention belongs to the technical field of manufacturing of biological, chemical or traditional Chinese medicine, relates to MES medicine manufacturing, and in particular relates to a method and a system for automatically adjusting the weighing sequence of a work order in MES medicine manufacturing.
Background
The MES system is a production informatization management system oriented to a workshop execution layer of a manufacturing enterprise, and is initially applied to medicine manufacturing.
In the process of medicine manufacture, the weighing link is a key link. When weighing, different extractors are required to be used to take the raw materials from the large package. Since chemical reactions may occur between different raw materials to affect the quality of medicines, the same extractor is required to be used for the raw materials which may have chemical reactions at the same time during weighing, so the extractor must be cleaned to be reused, and cleaning is obviously a relatively time-consuming process.
Therefore, how to improve the weighing efficiency in the material taking link is a problem to be solved urgently.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a method and a system for automatically adjusting the weighing sequence of a work order in MES medicine manufacture, so as to reduce the cleaning times of a material taking device and improve the weighing efficiency.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a method for automatically adjusting the weighing sequence of a work order in MES medicine manufacture includes such steps as extracting raw materials and weight needed by production from the work order, creating a poor chemical reaction table between raw materials, and sequentially weighing raw materials according to the order of more poor chemical reactions with other raw materials and the total weight of raw materials.
In one embodiment, the worksheets are all worksheets of each production cycle, the weighed raw materials are the total weight required by each raw material in all worksheets of each production cycle, and after the same raw material is weighed, raw materials are distributed to different worksheets according to the weight of the raw material in different worksheets.
In one embodiment, the adverse chemical reaction table between the raw materials refers to the adverse chemical reaction, that is, the mutual exclusion relationship, between each raw material and other raw materials, and the raw materials are ordered in order of the number of the adverse chemical reactions with other raw materials from the large to the small.
In one embodiment, when a certain raw material is weighed, if any raw material weighed before it does not have adverse chemical reaction with it, the extractor is cleaned and then weighing is performed.
The invention also provides a system for automatically adjusting the weighing sequence of the worksheets in MES medicine manufacturing, which comprises a raw material extraction unit, a raw material chemical reaction database, a sequencing unit and a weighing unit;
the raw material extraction unit extracts names of all raw materials from a work order;
the raw material chemical reaction database stores the adverse chemical reaction relation among raw materials;
the sequencing unit sequences the raw materials according to the poor chemical reaction relation among the raw materials and the order of the number of the poor chemical reactions with other raw materials from large to small;
and the weighing unit sequentially weighs the raw materials according to the sequencing.
In one embodiment, the raw material extracting unit extracts all the work orders of each production cycle from the production schedule table, and extracts raw material names of all the work orders of each production cycle.
In one embodiment, the raw chemical reaction database is established by:
inputting a first raw material;
inputting a second raw material, and establishing an adverse chemical reaction relation with the first raw material;
inputting a third raw material, and establishing an adverse chemical reaction relation with the first raw material and the second raw material;
……；
by analogy, every time a new raw material is input, establishing an adverse chemical reaction relation between the new raw material and all other raw materials;
thus, an editable and callable raw material chemical reaction database is formed.
In one embodiment, the sorting unit traverses all raw materials extracted from the work order, obtains the number of adverse chemical reactions of each raw material with other raw materials from the raw material chemical reaction database, enters a certain raw material when the raw material is missing in the raw material chemical reaction database, and establishes an adverse chemical reaction relation with other raw materials in the raw material chemical reaction database.
In one embodiment, the system of the present invention further comprises a reclaimer identification unit and an alert unit;
and after the weighing unit finishes weighing the current raw materials, if the next raw material and the current raw material do not have adverse chemical reaction relation, the material taking device identification unit identifies whether the material taking device is cleaned or replaced, and if the material taking device is not cleaned or replaced, the alarming unit alarms in real time.
In one embodiment, the system of the present invention further comprises a controller and a trigger;
the controller only outputs and displays one raw material name and the weighing total weight thereof at each time according to the raw materials ordered by the ordering unit;
and the trigger outputs a trigger signal to the controller when the weighing unit finishes weighing the raw materials once, and the controller outputs the name of the next raw material and the weighing total weight thereof according to the trigger signal.
Compared with the prior art, the method has the advantages that the raw materials are weighed according to the sequence of more than less bad chemical reactions by constructing the bad chemical reaction table among the raw materials, so that the cleaning times of the material taking device can be reduced to a certain extent, and the weighing efficiency is improved.
Drawings
Fig. 1 is a schematic diagram of the structure of the present invention.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings and examples.
As described above, in the prior art, when weighing raw materials, the material taking device is required to be not continuously used for weighing raw materials which may undergo chemical reaction, and in actual production, due to lack of guidance, the material taking device must be cleaned after each use on site, and then the material taking device can be used for weighing the next raw materials. However, there is currently no effective means to monitor this cleaning action and each time a cleaning is performed, it is obviously time consuming and laborious.
In order to maximize the use of a material extractor for materials that do not react chemically, a first object of the present invention is to provide a method for automatically adjusting the order of weighing work orders in MES pharmaceutical manufacturing, according to which firstly raw materials and weights required for production are extracted from work orders, a poor chemical reaction table between the raw materials is established, and the raw materials are sequentially weighed in order of more to less poor chemical reactions with other raw materials, according to the total weight of the raw materials.
The invention establishes a whole adverse chemical reaction table among raw materials, and the adverse chemical reaction relation between each raw material and other raw materials is embodied in the table. The invention orders the materials in a more to less order according to the adverse chemical reactions of each material with other materials, and a weighing order table is obtained, and the materials are weighed according to the table. When an adverse chemical reaction relationship exists between a certain raw material and the next raw material, the next raw material can be directly taken and weighed without cleaning the material taking device after the raw material is weighed, so that the cleaning times of the material taking device are greatly reduced, and the weighing efficiency is improved. In the traditional method, the weighing sequence of workers is random, and the method is obviously different from the efficiency and effect of the invention.
In the embodiment of the invention, the worksheets are all worksheets in each production cycle, the weighed raw materials are the total weight required by each raw material in all worksheets in each production cycle, and after the same raw material is weighed, the raw materials are distributed for different worksheets according to the weight of the raw material in different worksheets.
Since the required raw materials may overlap for different work orders in the same production cycle, the invention takes one production cycle as a unit to acquire all work orders in the cycle and further acquires the required raw materials and weight of all work orders. By this means, all work orders are uniformly processed from a higher level, and the weighing efficiency is further improved. In actual production, one production cycle is usually taken as one day, so that the weighing sequence of different raw materials in each day can be intelligently calculated according to the production plan of the total medicines in each day.
In the embodiment of the invention, the adverse chemical reaction table between raw materials refers to the adverse chemical reaction, namely mutual exclusion relation, between each raw material and other raw materials, and the raw materials are ordered according to the order of the number of the adverse chemical reactions with other raw materials from large to small.
The term "adverse chemical reaction" used in the present invention means that a chemical reaction does not occur between any two materials, or that although a chemical reaction can theoretically occur, the rate, degree, etc. of such a chemical reaction can be tolerated by a general process. In this case, the last material remaining in the reclaimer has no substantial effect on the next material. The invention can embody whether the mutual exclusion relation exists in the modes of 1 and 0 or other convenient modes, and further can conveniently finish the sequencing.
In the embodiment of the present invention, when the number of adverse chemical reactions of a certain raw material and other raw materials is equal, the weighing order of the raw materials is arbitrary.
In the embodiment of the invention, when one raw material is weighed, if any raw material weighed before the raw material does not have adverse chemical reaction with the raw material, the extractor is cleaned, and then the raw material is weighed.
In view of stability and reliability, in this embodiment, if a certain raw material is likely to react with any raw material previously weighed, it is necessary to clean the extractor first and then weigh the raw material.
The invention provides a system for automatically adjusting the weighing sequence of worksheets in MES medicine manufacturing, which comprises a raw material extraction unit, a raw material chemical reaction database, a sequencing unit and a weighing unit.
The raw material extraction unit extracts names of all raw materials from a work order;
the raw material chemical reaction database stores the adverse chemical reaction relation among raw materials;
the sequencing unit sequences the raw materials according to the poor chemical reaction relation among the raw materials and the order of the number of the poor chemical reactions with other raw materials from large to small;
and the weighing unit sequentially weighs the raw materials according to the sequencing.
In the embodiment of the invention, the raw material extraction unit can be a software module capable of crawling data, and can also be manually-entered form office software. It extracts all work orders for each production cycle from the production schedule table and extracts the raw material names of all work orders for each production cycle. Correspondingly, the extraction mode can be automatic crawling or manual input.
In an embodiment of the present invention, a raw chemical reaction database is established by:
inputting a first raw material;
inputting a second raw material, and establishing an adverse chemical reaction relation with the first raw material; illustratively, when it has a poor chemical reaction with feedstock one, the relationship between the two is defined as 1, and when it has no poor chemical reaction with feedstock one, the relationship between the two is defined as 0.
Inputting a third raw material, and establishing an adverse chemical reaction relation with the first raw material and the second raw material; likewise, when it has a poor chemical reaction with either raw material one or raw material two, the relationship with either raw material one or raw material two is defined as 1, and when it does not have a poor chemical reaction with either raw material one or raw material two, the relationship with either raw material one or raw material two is defined as 0.
……；
By analogy, every time a new raw material is entered, adverse chemical reaction relationships between the raw material and all other raw materials are established, and the relationships are respectively represented by 1 or 0.
Thus, an editable and callable raw material chemical reaction database is formed.
In this embodiment, the raw materials in each extracted work order may be separately tabulated, or the raw materials of the annual work order of the production line may be gradually and completely tabulated. When the latter is employed, all the materials and interrelationships between the materials for the current cycle are extracted from the summary table each time. The summary may also be used directly, but the duration of the traversal may be increased. Therefore, in practical applications, it is necessary to select the raw material type number, the raw material type number in the current cycle, the computing power of the processor, and the like in combination with practical situations.
In this embodiment, whether there is a chemical adverse reaction relationship between the two materials is determined by an online expert database, or by a worker based on experience, and a feedback modification mechanism is established.
In an embodiment of the invention, the sorting unit traverses all raw materials extracted from the work order, acquires the number of adverse chemical reactions of each raw material with other raw materials from the raw material chemical reaction database, and when a certain raw material is missing in the raw material chemical reaction database, enters the raw material and establishes an adverse chemical reaction relationship with other raw materials in the raw material chemical reaction database.
In this embodiment, taking the definition of 1 and 0 as an example, the raw materials having a relationship of at most 1 with other raw materials are selected first, and so on.
In an embodiment of the present invention, the system of the present invention further comprises a reclaimer identification unit and an alarm unit;
and after the weighing unit finishes weighing the current raw materials, if the next raw material and the current raw material do not have adverse chemical reaction relation, the material taking device identification unit identifies whether the material taking device is cleaned or replaced, and if the material taking device is not cleaned or replaced, the alarming unit alarms in real time. The identification means may be a trigger means installed in the cleaning device, for example, to monitor whether the cleaning device is activated during the time period between two weighings. Or based on the identification of the image characteristics, for example, an image identification module is adopted to collect the image of the material taking device when weighing next time, and whether residual materials exist on the material taking device or not is judged.
In this embodiment, by such determination, the phenomenon that the first-line person does not perform cleaning when cleaning is required can be eliminated. The provided identification modes are easy to realize, and the cost is not greatly increased.
In an embodiment of the invention, the system of the invention further comprises a controller and a trigger; the controller is used as a separate output unit and is used for controlling the output rhythm, namely, each raw material ordered by the ordering unit only outputs and displays one raw material name and the weighing total weight thereof at a time. The trigger is used for being matched with the controller to control the output rhythm, namely, when the weighing unit finishes weighing the raw materials for one time, a trigger signal is output to the controller, and the controller outputs the name of the next raw material and the weighing total weight of the next raw material according to the trigger signal.
In this example, the output cadence is controlled in order to allow only one person to obtain the weighed total weight of one raw material at a time. Thereby avoiding the situation that, although a weighing sequence is provided, a first-line person does not follow this sequence. Since only one raw material is output at a time and the total weight thereof is weighed, the first line personnel can only weigh the currently output raw materials, and cannot freely adjust the order. The triggering mode of the invention is preferably automatic triggering, for example, when the weighing data of the weighing unit is consistent with the weighing total weight output by the controller, the next output is automatically triggered. Or, the automatic output according to the estimated time is set, namely, the total time for weighing and distributing is completed according to the estimated current raw material requirement, and the next output is automatically triggered after the time. Or, an image recognition module is adopted to intercept several frames of images from the monitoring video, recognize the action of weighing completion and automatically trigger the next output. These triggering modes may be selected based on the computing capabilities of the field device.
In connection with fig. 1, the weighing process according to an embodiment of the invention is described as follows:
1, assuming that the production cycle is one day, the worksheets produced simultaneously every day are G1, G2, G3, … and Gn.
The raw materials required by each work order are different, for example, work order G1 needs 1,3 and 9 raw materials, work order G2 needs 3,8 and 9 raw materials, work order G3 needs 1,8 and 9 raw materials.
Calculating the total amount required by each raw material, such as the total amount N1 required by the raw material No. 1, the total amount N2 required by the raw material No. 2, … …, the total amount Nx required by the raw material No. x, then:
N1＝G1_1+G2_1+…+G3_1
N2＝G1_2+G2_2+…+G3_2
Nx＝G1_x+G2_x+…+G3_x
g1_1 represents the amount of raw material No. 1 required for the work order G1, g2_1 represents the amount of raw material No. 1 required for the work order G2, and g3_1 represents the amount of raw material No. 1 required for the work order G3; g1_2 represents the amount of raw material No. 2 required for the work order G1 (0 when not required), g2_2 represents the amount of raw material No. 2 required for the work order G2, and g3_2 represents the amount of raw material No. 2 required for the work order G3. And so on.
And 4, obtaining the number and the number of each raw material, and then obtaining a bad chemical reaction (mutual exclusion) table of each raw material. For example, M (1) =6, where (1) represents "raw material No. 1", and 6 represents that the number of mutual exclusion with raw material No. 1 is 6 among all the raw materials.
5: for x raw materials, M (1), M (2) … M (x), the highest numerical rank is at the forefront, generating a new sequence, for example: l1, L2, L3 … lx=m (2), M (4), M (1), M (3), …, M (X).
6: next, weighing is performed in the order of L, for example, after weighing L1 (corresponding to material No. 2), L2 (corresponding to material No. 4) is weighed again.
7: next, the changer, weigh L2, and material that does not react chemically with L2.
In theory, the number of the extractors is minimized, so that the number of times of cleaning the extractors is reduced, and the production efficiency is improved.
Claims (10)
- A method for automatically adjusting the weighing sequence of a work order in MES medicine manufacture is characterized in that raw materials and weight required by production are extracted from the work order, a poor chemical reaction table among the raw materials is established, and the raw materials are sequentially weighed according to the total weight of the raw materials according to the order of more poor chemical reactions with other raw materials.
- 2. The method of claim 1, wherein the worksheets are all worksheets of each production cycle, the weighed raw materials are total weight required by each raw material in all worksheets of each production cycle, and after the same raw material is weighed, raw materials are distributed to different worksheets according to the weight of the raw material in different worksheets.
- 3. The method of claim 1, wherein the list of adverse chemical reactions between the raw materials is a mutually exclusive relationship of the adverse chemical reactions between each raw material and other raw materials, and the raw materials are sorted in order of increasing number of adverse chemical reactions with the other raw materials.
- 4. A method for automatically adjusting a work order in the manufacture of MES medicines according to claim 3, wherein when a certain raw material is weighed, if any raw material weighed before it has no adverse chemical reaction with it, the extractor is cleaned and then weighed again.
- 5. The system for automatically adjusting the weighing sequence of the worksheets in MES medicine manufacturing is characterized by comprising a raw material extraction unit, a raw material chemical reaction database, a sequencing unit and a weighing unit;the raw material extraction unit extracts names of all raw materials from a work order;the raw material chemical reaction database stores the adverse chemical reaction relation among raw materials;the sequencing unit sequences the raw materials according to the poor chemical reaction relation among the raw materials and the order of the number of the poor chemical reactions with other raw materials from large to small;and the weighing unit sequentially weighs the raw materials according to the sequencing.
- 6. The system according to claim 5, wherein the raw material extracting unit extracts all the work orders for each production cycle from the production schedule table, and extracts the raw material names of all the work orders for each production cycle.
- 7. The system for automatically adjusting order of worksheets weighing in MES pharmaceutical manufacturing according to claim 5, wherein the raw material chemical reaction database is built by:inputting a first raw material;inputting a second raw material, and establishing an adverse chemical reaction relation with the first raw material;inputting a third raw material, and establishing an adverse chemical reaction relation with the first raw material and the second raw material;……；by analogy, every time a new raw material is input, establishing an adverse chemical reaction relation between the new raw material and all other raw materials;thus, an editable and callable raw material chemical reaction database is formed.
- 8. The system according to claim 5, wherein the sorting unit is configured to traverse all raw materials extracted from the worksheet, obtain the number of adverse chemical reactions of each raw material with other raw materials from the raw material chemical reaction database, and when a certain raw material is missing from the raw material chemical reaction database, enter the raw material, and establish an adverse chemical reaction relationship with other raw materials in the raw material chemical reaction database.
- 9. The system for automatically adjusting a work order in MES pharmaceutical manufacturing according to claim 5, further comprising a reclaimer identification unit and an alarm unit;and after the weighing unit finishes weighing the current raw materials, if the next raw material and the current raw material do not have adverse chemical reaction relation, the material taking device identification unit identifies whether the material taking device is cleaned or replaced, and if the material taking device is not cleaned or replaced, the alarming unit alarms in real time.
- 10. The system for automatically adjusting a work order in the manufacture of MES pharmaceutical products according to claim 5, further comprising a controller and a trigger;the controller only outputs and displays one raw material name and the weighing total weight thereof at each time according to the raw materials ordered by the ordering unit;and the trigger outputs a trigger signal to the controller when the weighing unit finishes weighing the raw materials once, and the controller outputs the name of the next raw material and the weighing total weight thereof according to the trigger signal.
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- 2023-02-08 CN CN202310083496.2A patent/CN116048025A/en active Pending
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| JP2008299838A (en) * | 2007-05-02 | 2008-12-11 | Ajinomoto Engineering Corp | Weighing control method, weighing control system, and weighing control program |
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