CN116042352B - Connection structure and biological reaction bag - Google Patents
Connection structure and biological reaction bag Download PDFInfo
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- CN116042352B CN116042352B CN202211734067.9A CN202211734067A CN116042352B CN 116042352 B CN116042352 B CN 116042352B CN 202211734067 A CN202211734067 A CN 202211734067A CN 116042352 B CN116042352 B CN 116042352B
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- 238000006243 chemical reaction Methods 0.000 title abstract description 7
- 238000009434 installation Methods 0.000 claims abstract description 11
- 230000000149 penetrating effect Effects 0.000 claims abstract description 8
- 230000003068 static effect Effects 0.000 claims abstract description 3
- 230000004044 response Effects 0.000 claims description 16
- 230000008878 coupling Effects 0.000 description 13
- 238000010168 coupling process Methods 0.000 description 13
- 238000005859 coupling reaction Methods 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 2
- 230000037237 body shape Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a connecting structure and a biological reaction bag, wherein the connecting structure comprises: the guide piece is arranged on the driving piece, an installation space is formed in the guide piece in a penetrating mode along the first direction, and a guide channel communicated with the installation space is formed in the guide piece; the first connecting piece is connected with the driving piece; the second connecting piece is detachably connected to one end, far away from the guide piece, of the first connecting piece along the first direction; the lifting unit is connected with one end of the first connecting piece, which is far away from the second connecting piece along the first direction; the guide channel is configured to guide the lifting unit to move along the guide channel; the lifting unit has an operating state and a loading and unloading state responsive to the driving member. The connecting structure comprises a lifting unit, wherein the lifting unit is arranged in a static state and a lifting state, and when the lifting unit is in a loading and unloading state, the lifting unit can move along the guide channel and drive the first connecting piece to move so that the first connecting piece and the second connecting piece are separated from each other, the biological reaction bag can be conveniently disassembled and assembled, and the replacement efficiency is improved.
Description
Technical Field
The invention relates to the technical field of bioreactors, in particular to a connecting structure and a bioreactor bag.
Background
When experiments are carried out in the bioreactor, a disposable bioreactor bag is usually arranged in the bioreactor, the experiments are carried out in the bioreactor bag, and each time the experiments are carried out, a new bioreactor bag needs to be replaced.
However, when the bioreactor bag is replaced, the bioreactor bag (comprising the bag body and the stirrer) needs to be detached from the bioreactor, and the stirrer is connected with the motor of the bioreactor, so that the bioreactor bag is difficult to detach due to the fixed installation position of the motor.
Disclosure of Invention
Based on this, it is necessary to provide a connection structure and a bioreactor bag that facilitate the detachment of the bioreactor bag from the motor.
According to one aspect of the present application, there is provided a connection structure for a bioreactor bag comprising a bag body and a stirrer disposed in the bag body, the stirrer being rotatable in response to a driving member, the connection structure comprising:
the guide piece is arranged on the driving piece, an installation space is formed in the guide piece in a penetrating mode along the first direction, and a guide channel communicated with the installation space is formed in the guide piece;
a first connecting piece connected with the driving piece;
the second connecting piece is detachably connected to one end, away from the guide piece, of the first connecting piece along the first direction; and
A lifting unit connected with one end of the first connecting piece far away from the second connecting piece along the first direction; the guide channel is configured to guide the lifting unit to move along the guide channel;
wherein the lifting unit has an operating state and a loading and unloading state responsive to the driving member;
the lifting unit is in the working state, and the first connecting piece and the second connecting piece are connected with each other;
the lifting unit is in the loading and unloading state, and the first connecting piece and the second connecting piece are separated from each other.
In the above-described connection structure, the guide passage is configured to guide the lifting unit to move along the guide passage, so that the lifting unit can be in an operating state and a loading and unloading state in response to the driving piece; through setting up first connecting piece and second connecting piece and can connect each other or separate each other, and the first connecting piece is connected to the lifting unit to when making the lifting unit be in loading and unloading state, the lifting unit can drive the removal of first connecting piece, with make first connecting piece and second connecting piece separate each other, thereby be convenient for dismouting biological reaction bag, improve the efficiency of changing the biological reaction bag.
In one embodiment, the driving member is a motor capable of rotating in a forward direction and a reverse direction;
the lifting unit is configured to be stationary in the operating state in response to a forward rotation of the motor, and the lifting unit is configured to be movable along the guide path in the loading and unloading state in response to a reverse rotation of the motor.
In one embodiment, the first connector comprises a first connection portion and a second connection portion connected to the first connection portion; one end, away from the second connecting piece, of the first connecting part along the first direction is connected with the driving piece;
the lifting unit comprises a lifting piece and a unidirectional rotating piece arranged on the lifting piece;
the lifting member is connected with one end of the second connecting part far away from the second connecting member along the first direction, and the lifting member is configured to be capable of moving along the guide channel;
the unidirectional rotating piece is sleeved at one end of the first connecting part connected with the driving piece; the unidirectional rotating member has an idle state in which the unidirectional rotating member rotates in response to the forward rotation of the driving member and a locking state in which the unidirectional rotating member is self-locked in response to the reverse rotation of the driving member;
the unidirectional rotating piece is in the idle state, and the lifting piece is in the working state;
the unidirectional rotating piece is in the locking state, and the unidirectional rotating piece drives the lifting piece to move along the guide channel under the driving of the driving piece so as to enable the lifting piece to be switched to the loading and unloading state.
In one embodiment, the guide channel has a start end and a finish end, the start end being downstream of the finish end in the first direction;
the lifting member is provided with a lifting portion matched with the guide channel, the lifting portion is configured to be capable of moving along the guide channel, and the lifting portion is arranged at an angle with the first direction.
In one embodiment, the lifting member is provided with a mounting cavity extending along the first direction, and the mounting cavity penetrates through one end of the lifting member, which is close to the second connecting member;
the inner wall of the mounting cavity is provided with a mounting groove along the circumferential direction of the mounting space, and one end of the second connecting part, which is far away from the second connecting part, is provided with a mounting part which is mounted in the mounting groove.
In one embodiment, the first connection portion includes a first section and a second section connected to the first section;
the first section is provided with a first mounting hole along the first direction, and the driving piece is mounted in the first mounting hole;
the second section is provided with a plurality of second mounting holes at intervals along the circumferential direction of the first mounting holes, and the second mounting holes penetrate through the second section along the first direction.
In one embodiment, the second connecting part comprises a third section and a plurality of fourth sections which are arranged in one-to-one correspondence with the second mounting holes;
the fourth section is connected with one side, close to the second connecting piece, of the third section along the first direction at intervals along the circumferential direction of the installation space;
the third section is provided with a third mounting hole penetrating through the third section along the first direction, and the first section penetrates through the third mounting hole.
In one embodiment, the second connecting pieces are provided with a plurality of fourth mounting holes which are arranged in one-to-one correspondence with the fourth sections at intervals along the circumferential direction of the mounting space.
In one embodiment, the second connector is further provided with a fifth mounting hole penetrating through the second connector along the first direction, the fourth mounting hole is disposed around the fifth mounting hole, and the fifth mounting hole is used for mounting the stirrer.
According to another aspect of the present application, there is provided a bioreactor bag comprising a connecting structure as defined in any one of the above, the bioreactor bag further comprising a stirrer and a driving member for driving the stirrer to rotate, the connecting structure being for connecting the stirrer and the driving member.
Drawings
FIG. 1 is an exploded view of a lifting unit of a connection structure, a driving member and a stirrer in a loading and unloading state according to an embodiment of the present application;
FIG. 2 is an exploded view of the lifting unit of the connection structure, the driving member and the agitator in an operating state according to an embodiment of the present disclosure;
FIG. 3 is a schematic view showing the assembly of the coupling structure of FIGS. 1 and 2 to a bioreactor bag according to the present application;
FIG. 4 is a schematic view of a part of a lifting unit in an operating state according to an embodiment of the present disclosure;
FIG. 5 is a schematic view of a part of a lifting unit in a loading and unloading state according to an embodiment of the present disclosure;
FIG. 6 is a schematic view showing the assembly of a bioreactor bag according to an embodiment of the present application.
Reference numerals illustrate:
100. a biological reaction bag; 10. a connection structure; 11. a guide member; 111. an installation space; 112. a guide channel; 12. a first connector; 121. a first connection portion; 1211. a first section; 1211a, a first mounting hole; 1212. a second section; 1212a, a second mounting hole; 122. a second connecting portion; 1221. a third section; 1221a, third mounting holes; 1221b, a mounting portion; 1222. a fourth section; 13. a second connector; 131. a fourth mounting hole; 132. a fifth mounting hole; 14. a lifting unit; 141. a lifting member; 1411. a lifting part; 1411a, connection holes; 1412. a mounting groove; 1413. a mounting cavity; 142. a unidirectional rotating member; 20. a bag body; 30. a stirrer; 50. a driving member; 51. an output shaft;
x, first direction.
Detailed Description
In order that the above objects, features and advantages of the invention will be readily understood, a more particular description of the invention will be rendered by reference to the appended drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may be embodied in many other forms than described herein and similarly modified by those skilled in the art without departing from the spirit of the invention, whereby the invention is not limited to the specific embodiments disclosed below.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present invention.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present invention, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
In the present invention, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.
It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are used herein for illustrative purposes only and are not meant to be the only embodiment.
FIG. 1 is an exploded view of a lifting unit of a connection structure, a driving member and a stirrer in a loading and unloading state according to an embodiment of the present application; FIG. 2 is an exploded view of the lifting unit of the connection structure, the driving member and the agitator in an operating state according to an embodiment of the present disclosure; FIG. 3 is a schematic view showing the assembly of the coupling structure of FIGS. 1 and 2 to the bioreactor bag.
Referring to fig. 1 to 3, and in conjunction with fig. 6, there is provided a coupling structure 10 for a bioreactor bag 100, the bioreactor bag 100 comprising a bag body 20 and a stirrer 30 provided in the bag body 20, the stirrer 30 being rotatable in response to a driving member 50.
Specifically, the connection structure 10 includes a guide 11, first and second connection members 12 and 13 detachably connected, and a lifting unit 14, the guide 11 being provided with a guide passage 112, and the guide passage 112 being configured to guide the lifting unit 14 to move along the guide passage 112, the lifting unit 14 having an operating state and a loading and unloading state in response to the driving member 50, the lifting unit 14 being in the operating state, the first and second connection members 12 and 13 being connected to each other; the lifting unit 14 is in a loading and unloading state, and the first and second links 12 and 13 are separated from each other.
Thus, by providing the guide member 11 provided with the guide channel 112, and the lifting unit 14 can move along the guide channel 112, when the lifting unit 14 is in the loading and unloading state in response to the driving member 50, the lifting unit 14 can drive the first connecting member 12 to move along the first direction in a direction away from the second connecting member 13, and because the first connecting member 12 and the second connecting member 13 are detachably connected, when the driving member 50 drives the first connecting member 12 to move along the first direction in a direction away from the second connecting member 13, the first connecting member 12 and the second connecting member 13 can be separated from each other, and the second connecting member 13 and the agitator 30 can be separated from the driving member 50, so that the agitator 30 can be detached from the driving member 50, thereby separating the bioreactor bag 100 from the driving member 50, and the operation is simple. With continued reference to fig. 1-3, the guide 11 is generally in the form of a solid of revolution, and the guide 11 is mounted to the driver 50 by fasteners. The guide 11 is provided with a mounting space 111 along a first direction (as shown in X direction in fig. 1 and 2), and the guide 11 is further provided with a guide channel 112 communicating with the mounting space 111, and the lifting unit 14 is movable along the guide channel 112. Wherein the axis of the mounting space 111 is arranged coincident with the axis of the guide 11, the guide channel 112 is configured to be able to guide the lifting unit 14 along the guide channel 112.
Thus, by providing the guide passage 112, the lifting unit 14 can be guided to move along the guide passage 112, thereby switching the lifting unit 14 between the operating state and the loading and unloading state.
In some embodiments, the guide channel 112 extends along the circumferential direction of the installation space 111, and the guide channel 112 is in a closed ring shape, and the dimension of the guide channel 112 in the first direction is the movable range of the lifting unit 14 along the first direction.
In some embodiments, the guide channel 112 is provided in a curved extension, the guide channel 112 having a start end and a finish end, the start end being downstream of the finish end in the first direction. It is understood that the lifting unit 14 is movable in the first direction while being moved in the circumferential direction of the installation space 111 during the loading and unloading state, so that the first and second connection members 12 and 13 are separated from each other; the guiding channel 112 is mainly used for guiding the movement of the lifting unit 14 along the first direction, and as long as the guiding channel 112 is arranged along the circumferential direction or extends along the curve, or has other specific shapes, the lifting unit 14 can be moved along the first direction, and no limitation is made here.
In some embodiments, the drive member 50 is a motor that is rotatable in both forward and reverse directions, the motor being provided with an output shaft 51, the lifting unit 14 being configured to be stationary in an operative state in response to the forward rotation of the motor, and the lifting unit 14 being configured to be movable along the guide channel 112 in a loading and unloading state in response to the reverse rotation of the motor.
It should be noted that, for convenience of description, in the following embodiments of the present application, the guide channel 112 is disposed in a curved extending manner, and the driving member 50 is described based on a motor that can rotate forward and backward. In addition, when the guide passage 112 is provided to extend in the circumferential direction of the installation space 111, the lifting unit 14 may be manually moved by an operator to move the lifting unit 14 along the guide passage 112, or the lifting unit 14 may be moved by driving means, which may be a motor, a driving cylinder, or the like, without limitation, and in such an embodiment, the driving member 50 functions to drive the rotation of the agitator 30, and it is not necessary to control the state of the lifting unit 14 by the reverse and reverse directions of the driving member 30.
Referring to fig. 1 and 2, the first connecting member 12 is integrally formed as a solid of revolution, and the first connecting member 12 is connected to the output shaft 51 of the driving member 50. Specifically, the first connecting member 12 includes a first connecting portion 121 and a second connecting portion 122 connected to the first connecting portion 121, and an end of the first connecting portion 121 remote from the second connecting member 13 in the first direction is connected to the output shaft 51 of the driving member 50. In this way, the output shaft 51 of the driving member 50 can drive the rotation of the first connecting portion 121.
Specifically, the first connection portion 121 includes a first segment 1211 and a second segment 1212 connected to the first segment 1211, the first segment 1211 having a first mounting hole 1211a formed along a first direction, the output shaft 51 of the driver 50 being mounted to the first mounting hole 1211a; the second segment 1212 is provided with a plurality of second mounting holes 1212a spaced apart in the circumferential direction of the first mounting hole 1211a, the second mounting holes 1212a penetrating the second segment 1212 in the first direction. The second connecting portion 122 includes a third section 1221 and a plurality of fourth sections 1222 corresponding to the second mounting holes 1212a one to one, the fourth sections 1222 are connected to one side of the third section 1221 near the second connecting member 13 along the first direction along the circumferential direction of the mounting space 111 at intervals, the third section 1221 is provided with a third mounting hole 1221a penetrating the third section 1221 along the first direction, and the first section 1211 is penetrated in the third mounting hole 1221a. Wherein, the end of the fourth section 1222 away from the third section 1221 may extend out of the second mounting hole 1212a to facilitate connection of the fourth section 1222 to the second connector 13. Optionally, the fourth segment 1222 is a pin, and an outer diameter of the fourth segment 1222 is smaller than an aperture of the second mounting hole 1212 a.
Thus, the output shaft 51 of the driving member 50 is connected to the first connecting portion 121, and drives the first connecting portion 121 to rotate the second connecting portion 122.
FIG. 4 is a schematic view of a part of a lifting unit in an operating state according to an embodiment of the present disclosure; fig. 5 is a schematic view of a part of a lifting unit in a loading and unloading state according to an embodiment of the present application.
Referring to fig. 4 and 5, and referring to fig. 1 to 3, the lifting unit 14 is integrally formed as a rotator, and the lifting unit 14 is connected to an end of the first connecting member 12 away from the second connecting member 13 along the first direction. Specifically, the lifting unit 14 includes a lifting member 141 and a unidirectional rotating member 142 mounted to the lifting member 141, the lifting member 141 being connected to an end of the second connecting portion 122 remote from the second connecting portion 13 in the first direction, the lifting member 141 being configured to be movable along the guide passage 112. More specifically, the lifting member 141 is provided with a lifting portion 1411 cooperating with the guide channel 112, the lifting portion 1411 being configured to be movable along the guide channel 112, the lifting portion 1411 being disposed at an angle to the first direction. The lifting member 141 is provided with a mounting cavity 1413 extending along the first direction, the mounting cavity 1413 penetrates through one end of the lifting member 141, which is close to the second connecting member 13, the inner wall of the mounting cavity 1413 is provided with a mounting groove 1412 along the circumferential direction of the mounting space 111, and one end of the second connecting portion 122, which is far away from the second connecting member 13, is provided with a mounting portion 1221b mounted in the mounting groove 1412. Wherein, the lifting portion 1411 is provided with a connection hole 1411a communicating with the mounting cavity 1413, the driving member 5021 extends into the connection hole 1411a to be connected with the first segment 1211 of the first connecting portion 121, and the mounting cavity 1413 is used for accommodating the first connecting member 12.
As such, by providing the lifting portion 1411 to cooperate with the guide channel 112, and the lifting portion 1411 being configured to be movable along the guide channel 112, the lifting member 141 is able to move along the guide channel 112; the lifting member 141 is connected to one end of the second connecting portion 122 away from the second connecting portion 13 along the first direction, so that the lifting member 141 can drive the first connecting portion 12 to move along the first direction in the process of moving along the guiding channel 112, and the first connecting portion 12 and the second connecting portion 13 are separated from each other, so that the bioreactor bag 100 can be conveniently disassembled and assembled, and the replacement efficiency of the bioreactor bag 100 is improved.
The unidirectional rotating member 142 is in a revolving body shape, and the unidirectional rotating member 142 is sleeved at one end of the first connecting portion 121 connected with the output shaft 51 of the driving member 50. The unidirectional rotation member 142 has an idle state in which it rotates in response to the forward rotation of the driving member 50, and a locked state in which it is self-locking in response to the reverse rotation of the driving member 50. The unidirectional rotation member 142 is in an idle state, and the lifting member 141 is in an operating state; the unidirectional rotating member 142 is in a locking state, and the unidirectional rotating member 142 drives the lifting member 141 to move along the guide channel 112 under the driving of the driving member 50, so that the lifting member 141 is switched to the loading and unloading state. In other words, the one-way rotation member 142 can only rotate in a clockwise or counterclockwise direction about its axis.
In some embodiments, the unidirectional rotation member 142 is a unidirectional bearing. Specifically, the inner ring bearing hole of the one-way bearing is communicated with the connecting hole 1411a and the mounting cavity 1413, the first segment 1211 of the first connecting part 121 is sleeved on the inner ring of the one-way bearing, and is in transition fit with the inner ring of the one-way bearing, and the outer ring of the one-way bearing is mounted on the lifting member 141. The connection manner of the outer ring of the unidirectional ring Cheng and the lifting member 141 may be a clamping connection, a welding connection, or the like, which is not limited herein. When the driving member 50 rotates forward, the one-way bearing is in an idle state in which the inner ring rotates and the outer ring does not rotate, and the lifting member 141 is in a static working state; when the driving member 50 rotates reversely, the one-way bearing is in a locking state in which the inner ring and the outer ring rotate synchronously, and the lifting member 141 can be driven to move due to the rotation of the outer ring of the one-way bearing, and the lifting member 141 is in a loading and unloading state moving along the guide channel 112.
In this way, the unidirectional rotating member 142 with the idle state and the locking state is provided, so that the lifting member 141 is in the corresponding working state and the loading and unloading state, and the operation is simple and convenient.
With continued reference to fig. 2, the second connector 13 is detachably connected to an end of the first connector 12 remote from the guide 11 in the first direction, and the second connector 13 is used for connecting to the agitator 30. The second connection member 13 is provided with a plurality of fourth mounting holes 131 arranged in one-to-one correspondence with the fourth segments 1222 at intervals along the circumferential direction of the mounting space 111. Wherein the aperture of the fourth mounting hole 131 near one end of the first link 12 in the first direction is slightly larger than the aperture of the other end so that the fourth segment 1222 and the second link 13 are separated from each other when the driving member 50 is reversed.
The second connection member 13 is provided with a second connection member fifth mounting hole 132 in the first direction, and a fourth mounting hole 131 is provided around the fifth mounting hole 132, the fifth mounting hole 132 being for mounting the agitator 30. Alternatively, the inner circumferential surface of the fifth mounting hole 132 is provided with an internal thread, and the outer circumferential surface of the stirrer 30 near one end of the second connection member 13 in the first direction is provided with an external thread, and the second connection member 13 is screw-coupled with the stirrer 30.
Thus, when the lifting unit 14 is in an operating state, the output shaft 51 of the driving member 50 sequentially transmits the driving force to the first coupling member 12, the second coupling member 13 and the agitator 30, so that the agitator 30 agitates the culture solution contained in the bioreactor bag 100; when the lifting unit 14 is in the loading and unloading state, the output shaft 51 of the driving member 50 sequentially drives the first coupling member 12 and the lifting unit 14 to separate the first coupling member 12 and the second coupling member 13 from each other; by providing the first coupling member 12 and the second coupling member 13 in detachable connection, the second coupling member facilitates the disassembly and assembly of the bioreactor bag 100 after the first coupling member 12 and the second coupling member 13 are separated from each other, which is advantageous in improving the efficiency of replacing the bioreactor bag 100.
FIG. 6 is a schematic view showing the assembly of a bioreactor bag according to an embodiment of the present application.
The application also provides a bioreactor bag 100, including the connection structure 10 of any one of the embodiments, the bioreactor bag 100 further includes a bag body 20 and a stirrer 30 arranged in the bag body 20, the bioreactor bag 100 is used in a bioreactor, the bioreactor includes a driving member 50, the driving member 50 is used for driving the stirrer 30 to rotate, and the connection structure 10 is used for connecting the stirrer 30 and the driving member 50.
In the case of replacing the bioreactor bag 100, the second connector 13, the agitator 30 and the bag 20 should be replaced.
In summary, the present application provides a connection structure 10 and a bioreactor bag 100, by providing a guide member 11 with a guide channel 112, and the lifting unit 14 is configured to move along the guide channel 112 when the driving member 50 is reversed, so as to drive the second connection portion 122 to move along a first direction in a direction away from the second connection member 13, and since the second connection portion 122 and the second connection member 13 are detachably connected, when the driving member 50 drives the second connection portion 122 to move along the first direction in a direction away from the second connection member 13, the second connection portion 122 and the second connection member 13 are separated, so that the agitator 30 can be separated from the driving member 50, and the operation is simple; the second connection member 13 can be separated from the agitator 30 by detachably connecting the second connection member 13 to the agitator 30, thereby enabling the second connection member 13 to be connected to the replaced agitator 30.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (8)
1. A connecting structure for a bioreactor bag, the bioreactor bag comprising a bag body and a stirrer arranged in the bag body, the stirrer being rotatable in response to a driving member, the driving member being rotatable in forward and reverse directions; the connecting structure is characterized by comprising:
the guide piece is arranged on the driving piece, a mounting space is formed in the guide piece in a penetrating mode along the first direction, an output shaft of the driving piece is located in the mounting space, and a guide channel communicated with the mounting space is formed in the guide piece;
a first connecting member including a first connecting portion and a second connecting portion connected to each other, the first connecting portion being movable in the first direction with respect to the second connecting portion; one end, far away from the stirrer, of the first connecting part along the first direction is connected with an output shaft of the driving piece;
the second connecting piece is detachably connected to the second connecting part along the first direction; the second connecting piece is provided with a fourth mounting hole and a fifth mounting hole which penetrate through the second connecting piece along the first direction, the fourth mounting hole can be used for movably inserting the second connecting part, and the fifth mounting hole is used for mounting the stirrer; and
A lifting unit connected with one end of the first connecting piece far away from the second connecting piece along the first direction; the lifting unit comprises a lifting piece and a unidirectional rotating piece arranged on the lifting piece; the lifting piece is connected with one end of the second connecting part far away from the second connecting piece along the first direction, and is provided with a lifting part matched with the guide channel; the unidirectional rotating piece is sleeved at one end of the first connecting part connected with the driving piece;
wherein the guide channel is positioned on the inner wall of the guide piece and is provided with a starting end and a terminating end; the guide channel is configured to guide the lifting part to move along the guide channel;
the unidirectional rotating member has an idle state in which the unidirectional rotating member rotates in response to the forward rotation of the driving member and a locking state in which the unidirectional rotating member is self-locked in response to the reverse rotation of the driving member;
when the unidirectional rotating piece is in the idle state, the lifting piece is in a static state, the first connecting piece and the second connecting piece are connected with each other, and the second connecting part is connected with the fourth mounting hole;
when the unidirectional rotating piece is switched to the self-locking state, the lifting piece responds to the reverse rotation of the driving piece to enable the lifting part to move along the guide channel so as to drive the first connecting piece to move along the first direction in a direction away from the second connecting piece, and the second connecting part is separated from the fourth mounting hole;
the first direction is perpendicular to the horizontal direction.
2. The connection according to claim 1, wherein the start end is downstream of the end in the first direction;
the lifting part is arranged at an angle with the first direction.
3. The connecting structure according to claim 1 or 2, wherein the lifting member is provided with a mounting cavity extending in the first direction, and the mounting cavity penetrates through one end of the lifting member, which is close to the second connecting member;
the inner wall of the mounting cavity is provided with a mounting groove along the circumferential direction of the mounting space, and one end of the second connecting part, which is far away from the second connecting part, is provided with a mounting part which is mounted in the mounting groove.
4. The connection structure according to claim 1 or 2, wherein the first connection portion includes a first section and a second section connected to the first section;
the first section is provided with a first mounting hole along the first direction, and the driving piece is mounted in the first mounting hole;
the second section is provided with a plurality of second mounting holes at intervals along the circumferential direction of the first mounting holes, and the second mounting holes penetrate through the second section along the first direction.
5. The connection structure according to claim 4, wherein the second connection portion includes a third section and a plurality of fourth sections provided in one-to-one correspondence with the second mounting holes;
the fourth section is connected with one side, close to the second connecting piece, of the third section along the first direction at intervals along the circumferential direction of the installation space;
the third section is provided with a third mounting hole penetrating through the third section along the first direction, and the first section penetrates through the third mounting hole.
6. The connection structure according to claim 5, wherein the second connection member is provided with a plurality of the fourth mounting holes provided in one-to-one correspondence with the fourth segments at intervals in a circumferential direction of the mounting space.
7. The connection structure according to claim 6, wherein a plurality of the fourth mounting holes are provided around the fifth mounting hole.
8. A bioreactor bag comprising the connecting structure of any one of claims 1-7, further comprising a stirrer and a driving member for driving the stirrer to rotate, wherein the connecting structure is used for connecting the stirrer and the driving member.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211734067.9A CN116042352B (en) | 2022-12-30 | 2022-12-30 | Connection structure and biological reaction bag |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211734067.9A CN116042352B (en) | 2022-12-30 | 2022-12-30 | Connection structure and biological reaction bag |
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| Publication Number | Publication Date |
|---|---|
| CN116042352A CN116042352A (en) | 2023-05-02 |
| CN116042352B true CN116042352B (en) | 2024-04-05 |
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| CN202211734067.9A Active CN116042352B (en) | 2022-12-30 | 2022-12-30 | Connection structure and biological reaction bag |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112980678A (en) * | 2021-02-04 | 2021-06-18 | 上海璟良生物工程技术有限公司 | Cylindrical surface coupling overhead type magnetic stirrer for disposable biological reaction bag |
| CN112980654A (en) * | 2021-02-04 | 2021-06-18 | 上海璟良生物工程技术有限公司 | Disposable bioreactor adopting cylindrical surface coupling overhead magnetic stirrer |
| CN214991612U (en) * | 2021-03-30 | 2021-12-03 | 山东先声生物制药有限公司 | Novel microbial fermentation device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008101124A1 (en) * | 2007-02-15 | 2008-08-21 | Broadley-James Corporation | Sterile bioreactor bag with integrated drive unit |
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- 2022-12-30 CN CN202211734067.9A patent/CN116042352B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112980678A (en) * | 2021-02-04 | 2021-06-18 | 上海璟良生物工程技术有限公司 | Cylindrical surface coupling overhead type magnetic stirrer for disposable biological reaction bag |
| CN112980654A (en) * | 2021-02-04 | 2021-06-18 | 上海璟良生物工程技术有限公司 | Disposable bioreactor adopting cylindrical surface coupling overhead magnetic stirrer |
| CN214991612U (en) * | 2021-03-30 | 2021-12-03 | 山东先声生物制药有限公司 | Novel microbial fermentation device |
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| CN116042352A (en) | 2023-05-02 |
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